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Dissertations / Theses on the topic 'Nicotine'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Harrington, Lauriane. "The role of β4-containing nicotinic acetylcholine receptors in nicotine addiction". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066328/document.

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Le tabac est consommé par environ un milliard de personnes. D'après l'Organisation Mondiale de la Santé, le tabagisme est la première cause évitable de mortalité dans le monde, provocant six millions de morts par an. La nicotine est le composant neuro-actif principal dans le tabac, et exerce ses effets neurologiques via une activation directe des récepteurs nicotiniques de l’acétylcholine (nAChR). Ces récepteurs transmembranaires sont composés de sous-unités alpha, ou alpha plus beta, créant une variété de canaux ioniques ligand-dépendants activés par le neurotransmetteur ACh. Les études génét

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2

Munhoz, Egberto [UNESP]. "Administração subcrônica de nicotina modifica as respostas neuroendócrina e neuroquímica induzidas pelo teste de natação forçada." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/104039.

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Made available in DSpace on 2014-06-11T19:32:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-12-13Bitstream added on 2014-06-13T18:44:37Z : No. of bitstreams: 1 munhoz_e_dr_arafo.pdf: 3085541 bytes, checksum: f014aca5c4e34e1bd024219270c2acaf (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O estresse, atualmente, é considerado um fator importante na fisiopatologia de muitos distúrbios psiquiátricos. Embora os efeitos do estresse agudo possam ser contrabalanceados por respostas adaptativas, o estresse intenso, repetido ou prolongado pode eliciar alterações n

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3

Drasdo, Alison L. "Studies of brain nicotinic acetylchlorine receptors : with respect to nicotine dependence." Thesis, University of Bath, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332792.

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4

James, John Randolph. "Evidence That Nicotine Can Acutely Desensitize Central Nicotinic Cholinergic Receptors In Vivo." VCU Scholars Compass, 1992. http://scholarscompass.vcu.edu/etd/3935.

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Current concepts concerning nicotine's central nervous system (CNS) mechanism(s) of action suggest that this drug is producing its effects via an interaction at nicotiniccholinergic receptors (nAChRs) which open a membrane cation channel. Following initial opening of the channel, nicotine appears to induce a rapid desensitization of the nAChRs, closing the channel and resulting in a cessation of nicotine's effects. Research presented here will provide evidence of this secondary desensitization process in vivo by demonstrating nicotine's ability to induce acute tolerance in the discriminative s

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5

Jones, Jeb. "Nicotine and responding maintained by conditioned reinforcers effects of two nicotinic antagonists /." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0041268.

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6

Larsen, James D. "Nicotinic Acetylcholine Receptor Dependent Effects of Nicotine on HEK293T and HBO Cells." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5701.

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T2R receptors are the classical bitter taste receptors which detect and transduce bitter taste in a subset of taste receptor cells (TRCs). The TRPM5-dependent T2Rs are G-protein coupled receptors (GPCRs) and are linked to G protein, gustducin to initiate an intracellular signaling cascade for the transduction of bitter tastants. Nicotine is bitter. However, at present the transduction mechanisms for the detection of nicotine in are poorly understood. Previous studies from our laboratory using TRPM5 knockout (KO) mice demonstrated that the T2R pathway is insufficient in explaining the taste per

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7

DiMaggio, Stassi. "Development of Novel Nicotinic Receptor Mediated Therapeutic Agents: Synthesis and Biological Evaluation of Novel Epibatidine Analogs and the First Total Synthesis of Anabasamine and Related Analogs." ScholarWorks@UNO, 2003. http://scholarworks.uno.edu/td/40.

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In an effort to search for a more selective, less toxic neuronal nicotinic acetylcholine receptor analgesic agent in comparison to epibatidine, a series of analogs with hybrid structures of epibatidine and ABT-594 were designed and synthesized. The 1-(pyridyloxymethyl)-7-azabicyclo[2.2.1]heptane ring systems were furnished via an intramolecular cyclization from a trans 1, 4 disubstitituted amino-cyclohexane derivative. The functionalized cyclohexane ring was formed via a [4+2] Diels-Alder cyclization reaction between the acetamidoacrylate and Danishefsky's diene. These 1- (pyridyloxymethyl)-7-

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8

Bowker, Katharine. "The effectiveness of nicotine replacement therapy during pregnancy : investigating the role of nicotine substitution, nicotine metabolism and pregnant smokers' experiences." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32138/.

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Nicotine replacement therapy (NRT) is effective in non-pregnant populations at assisting smoking cessation, but there is no evidence that NRT can help pregnant smokers to stop. Nicotine metabolism increases during pregnancy, and so the nicotine dose delivered by NRT could be insufficient for ameliorating withdrawal symptoms. However, little is known about the level of nicotine substitution provided by NRT or the pattern of nicotine metabolism during pregnancy. Also low adherence to NRT may explain why NRT does not appear to be effective. The overall aim of this thesis was to increase understan

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9

Vallaster, Markus Parzival. "Intergenerational Effects of Nicotine in an Animal Model of Paternal Nicotine Exposure." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/913.

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Environmental conditions imposed onto organisms during certain phases of their life cycles such as embryogenesis or puberty can not only impact the organisms’ own health, but also affect subsequent generations. The underlying mechanisms causing intergenerational phenotypes are not encoded in the genome, but the result of reversible epigenetic modifications. This work investigates in a mouse model the impact of paternal nicotine exposure on the next generation regarding addictive behavior modulation, metabolic changes, and molecular mechanisms. It provides evidence that male offspring from nico

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10

Vallaster, Markus Parzival. "Intergenerational Effects of Nicotine in an Animal Model of Paternal Nicotine Exposure." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/913.

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Environmental conditions imposed onto organisms during certain phases of their life cycles such as embryogenesis or puberty can not only impact the organisms’ own health, but also affect subsequent generations. The underlying mechanisms causing intergenerational phenotypes are not encoded in the genome, but the result of reversible epigenetic modifications. This work investigates in a mouse model the impact of paternal nicotine exposure on the next generation regarding addictive behavior modulation, metabolic changes, and molecular mechanisms. It provides evidence that male offspring from nico

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11

McCarthy, Michael J. "Regulation of the endogenous opioid system by acute nicotine and nicotine withdrawal." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1076018422.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 172 p.; also includes graphics (some col.). Includes bibliographical references (p. 131-172 ). Available online via OhioLINK's ETD Center

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12

Nelson, Christopher B., and Hans-Ulrich Wittchen. "Smoking and Nicotine Dependence." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-99925.

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This paper describes the distribution of dependence criteria and diagnoses in a sample of 14- to 24-year-olds from Munich, Germany (n = 3,021; 71% response rate), evaluates differences between nondependent and dependent smokers and examines associations of smoking with other substances, affective and anxiety disorders. Assessment was made using the M-CIDI. The lifetime prevalence of DSM-IV nicotine dependence in the total sample is 19%, rising to 52% among regular smokers. No gender differences were seen in the progression from regular smoking to nicotine dependence, although men were more lik

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13

Alasmari, Fawaz Fayez. "Chronic Exposure to Electronic Cigarette Vapor-Containing Nicotine and Co-Exposure to Alcohol and Nicotine: Effects on Glial Glutamate Transporters, Nicotinic Receptors and Neurotransmitters." University of Toledo Health Science Campus / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=mco1525349376479605.

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14

Hildreth, Sherry Boston. "Investigation of Protein-Protein Interactions among Nicotine Biosynthetic Enzymes and Characterization of a Nicotine Transporter." Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/29698.

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Alkaloids are a class of plant secondary metabolites produced in about 20% of plant families. Domesticated tobacco, Nicotiana tabacum produces nicotine as the predominant alkaloid. The biosynthesis of nicotine occurs exclusively in the roots of tobacco, yet accumulates in the leaves of tobacco where it is acts as a defense compound to deter insect herbivory. The research detailed in this dissertation addresses two aspects of nicotine physiology in tobacco: 1) an investigation of hypothesized protein-protein interactions among nicotine biosynthetic enzymes and 2) the characterization of a novel

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15

Hildreth, Sherry B. "Investigation of Protein-Protein Interactions among Nicotine Biosynthetic Enzymes and Characterization of a Nicotine Transporter." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/29698.

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Alkaloids are a class of plant secondary metabolites produced in about 20% of plant families. Domesticated tobacco, Nicotiana tabacum produces nicotine as the predominant alkaloid. The biosynthesis of nicotine occurs exclusively in the roots of tobacco, yet accumulates in the leaves of tobacco where it is acts as a defense compound to deter insect herbivory. The research detailed in this dissertation addresses two aspects of nicotine physiology in tobacco: 1) an investigation of hypothesized protein-protein interactions among nicotine biosynthetic enzymes and 2) the characterization of a novel

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16

Jackson, Asti. "Investigating the Modulation and Mechanisms of α7 Nicotinic Acetylcholine Receptors in Nicotine Dependence". VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4851.

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Tobacco dependence dramatically increases health burdens and financial costs. Limitations of current smoking cessation therapies indicate the need for improved molecular targets. Nicotine, the main addictive component of tobacco, exerts its dependency effects via nicotinic acetylcholine receptors (nAChRs). The homomeric α7 nAChR is one of the most abundant receptors found in the brain and has unique features in comparison to other nAChR subtypes such as high calcium permeability, low probability of channel opening, and a rapid desensitization rate. α7 nAChR agonists reduce nicotine's rewarding

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17

Carle, Carolyn M. "Nicotine Withdrawal Symptoms and Utilization of Nicotine Replacement Therapy in Critically Ill Smokers." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337876574.

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18

Moraes, Ricardo Oliveira de [UNESP]. "Influência do laser em baixa intensidade no processo de reparo de de enxerto ósseo autógeno implantado em bloco na mandíbula de ratos modificados sistemicamente com nicotina: estudo histo- morfométrico." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/96151.

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Made available in DSpace on 2014-06-11T19:28:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-08-18Bitstream added on 2014-06-13T20:57:34Z : No. of bitstreams: 1 moraes_ro_me_araca.pdf: 3762007 bytes, checksum: 9c2ec9715d0b3a85fbf41e3f7be91181 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Introdução: A nicotina, uma das drogas mais nocivas a saúde, causa, entre outros fatores, morbidade do enxerto ósseo e compromete a cicatrização óssea. Por outro lado, o tratamento com laser em baixa intensidade pode proporcionar efeitos bioestimulantes, aumentando

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19

Munhoz, Egberto. "Administração subcrônica de nicotina modifica as respostas neuroendócrina e neuroquímica induzidas pelo teste de natação forçada /." São Carlos, 2010. http://hdl.handle.net/11449/104039.

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Orientador: Cleopatra da Silva Planeta<br>Banca: Azair Liane Matos do Canto de Souza<br>Banca: Carlos César Crestani<br>Banca: Mirtes Costa<br>Banca: Marcelo Tadeu Marin<br>Resumo: O estresse, atualmente, é considerado um fator importante na fisiopatologia de muitos distúrbios psiquiátricos. Embora os efeitos do estresse agudo possam ser contrabalanceados por respostas adaptativas, o estresse intenso, repetido ou prolongado pode eliciar alterações neuronais duradouras que constituirão as bases de doenças psiquiátricas, como a depressão. Levantamentos epidemiológicos também mostram elevada prev

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20

Matheus, Henrique Rinaldi. "Avaliação da influência da quimioterapia com cisplatina ou 5-fluorouracil sobre o processo de reparo ósseo em implantes osseointegrados instalados em tíbias de ratos expostos ou não à nicotina /." Araçatuba, 2019. http://hdl.handle.net/11449/180853.

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Orientador: Juliano Milanezi de Almeida<br>Banca: Edilson Ervolino<br>Banca: Estevam Augusto Bonfante<br>Resumo: Objetivo: avaliar a influência da nicotina e dos agentes antineoplásicos Cisplatina (CIS) e 5-fluorouracil (5-FU) sobre os tecidos peri-implantares, bem como os efeitos desses agentes antineoplásicos sobre os tecidos peri-implantares em animais previamente expostos à nicotina. Material e métodos: 180 ratos machos (Wistar) foram randomizados para dois grandes grupos (n=90), NIC e SS, em seguida, para três subgrupos (n=30) de acordo com os agentes antineoplásicos. Receberam 0,5ml de s

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21

De, Preter C. C., Liza J. Hernandez, Seth L. Kirby, et al. "Adolescent Methylphenidate Exposure Alters Nicotine Self-Administration and the Accumbal Firing Response to Nicotine." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/971.

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This study was designed to analyze the effects of adolescent exposure to methylphenidate (MPH; trade name: Ritalin) on nicotine self-administration, the motivation to obtain nicotine, and accumbal neuronal firing rate in female adolescent rats. MPH is the most commonly prescribed medication for Attention Deficit-Hyperactivity Disorder (ADHD) which is diagnosed in 3-5% of adolescents in the United States. However, this disorder is often misdiagnosed, and MPH is often prescribed to individuals not diagnosed with ADHD. Adolescent female Sprague-dawley rats were ip administered 1 mg/kg MPH or sali

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22

Saravia, Santos Rocio 1988. "Novel insights in nicotine addiction : focus on cognitive function." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/665841.

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Cigarette smoking continues to be leading cause of preventable cause of death worldwide. Cognitive modulation by nicotine seems to be a key factor in nicotine addiction. Several studies indicate that initial nicotine intake has a positive effect on cognition, which may contribute to the development of nicotine dependence. Conversely, when chronic nicotine treatment ceases, cognitive functioning is altered. The orexin and the endocannabinoid system have been reported to play a crucial role in different stages of nicotine addiction and in learning and memory processes. Our results show that orex

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23

De, Villiers Sabina. "Active immunization against nicotine dependence." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-829-7/.

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24

Thomas, Gareth Andrew Osbert. "Nicotine therapy for ulcerative colitis." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309526.

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25

Mariner, Derek Christopher. "Nicotine - the mechanisms of uptake." Thesis, University of Surrey, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314871.

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26

Tsai, Mui Chiung. "Metabolic studies of S-(-)-nicotine." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261707.

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27

Young, Jared W. "Nicotine induced improvements in cognition : a possible role for the α7 nicotinic acetylcholine receptor". Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/27731.

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Assessment of sustained attention in rodents can be performed using the 5-choice serial reaction-time (5-CSR) task; analogous to the continuous performance test used in man. A 5-CSR protocol was established which allowed the demonstration of nicotine-induced improvements in sustained attention in mice. In this task α7 nAChR knockout (KO) mice exhibited impaired acquisition and performance, providing additional evidence that this receptor may be a valid therapeutic target for cognitive enhancement. In order to investigate the role of nAChR manipulation on working memory, the odour span task, a

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28

Claude, J. P. "Nutrition minérale et régulation de la synthèse de la nicotine chez Nicotiana tabacum L." Doctoral thesis, Universite Libre de Bruxelles, 1985. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213637.

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29

Barik, Jacques. "Nicotinic modulation of cellular and molecular processes : impact of chronic nicotine and its withdrawal." Thesis, University of Bath, 2006. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428384.

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There is a growing body of evidence that nicotinic acetylcholine receptors (nAChR) within the central nervous system (CNS) modulate a variety of cellular processes, including neurotransmitter release and signalling cascades. nAChR are ligand gated cation channels. The large diversity of nAChR subunits gives rise to functional homoand hetero-pentameric nAChR, and dictates their distinct intrinsic pharmacological properties. A further degree of complexity is reached by the non-uniform pattern of distribution of nAChR through the CNS. This research project has focused on several aspects of the mo

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30

Manzano, Beatriz Martins [UNESP]. "Variabilidade da frequência cardíaca como ferramenta de análise da função autonômica de tabagistas: revisão de literatura e estudo do plot de Poincaré." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/87320.

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Made available in DSpace on 2014-06-11T19:22:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-12-11Bitstream added on 2014-06-13T20:09:54Z : No. of bitstreams: 1 manzano_bm_me_prud.pdf: 326376 bytes, checksum: 0b7d0d1cb3bdf834e64a73541c8ddedd (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O tabagismo é considerado um dos principais fatores de risco modificáveis de doenças cardiovasculares e suas complicações, dentre as quais doença vascular aterosclerótica, hipertensão, infarto do miocárdio, angina instável e morte súbita. Os efeitos cardiovasculares

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31

Zirger, Jeffrey M. "Cloning, Expression and Functional Analysis of the Zebrafish Neuronal Nicotinic Acetylcholine Receptor." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1052847984.

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32

Stafford, Alexandra M. "alpha6 beta2 subunit containing nicotinic acetylcholine receptor contributions to abuse-related effects of nicotine and alcohol." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4778.

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Pharmacotherapies for tobacco and alcohol cessation are only modestly successful, so it is important to better understand mechanisms underlying their use and abuse. The overarching goal of this research is to assess a6b2 subunit containing nicotinic acetylcholine receptor (a6b2*nAChR; *denotes possible assembly with other subunits) contributions to abuse-related effects of nicotine and alcohol. In the absence of a6b2*nAChR-selective agonists, a6b2*nAChR gain-of-function (a6L9’S) mice provide a tool for selective activation of a6b2*nAChRs. Using the a6L9’S mice together with nicotine doses sub-

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Jackson, Kia. "Identification of Pharmacological and Molecular Mechanisms involved in Nicotine Withdrawal." VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/1616.

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Tobacco dependence is the leading cause of preventable death in the United States. Despite currently available smoking cessation therapies, there is a high rate of relapse in smoking among those attempting to quit. While the somatic signs of nicotine withdrawal (insomnia, increased appetite, weight gain) contribute to the continuation of smoking behavior, it has been hypothesized that the affective signs (depression, anxiety, craving, irritability) are greater motivators of relapse and continued tobacco use. There are few studies that assess the molecular and receptor-mediated mechanisms of ni

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34

Penton, Rachel E. "Changes in hippocampal excitability during withdrawal from chronic nicotine." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2008. https://www.mhsl.uab.edu/dt/2008p/penton.pdf.

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Henzelin-Nkubana, Céline. "Elaboration d'un vaccin anti-nicotine : développement et synthèse de conjugués immunogéniques de dérivés de la nicotine /." [S.l.] : [s.n.], 2003. http://library.epfl.ch/theses/?nr=2682.

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36

Middleton, Lisa Sue. "Nicotine receptor modulation of dopamine transporters." Lexington, Ky. : [University of Kentucky Libraries], 2005. http://lib.uky.edu/ETD/ukyphsc2006d00383/Middleton.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2005.<br>Title from document title page (viewed on March 2, 2006). Document formatted into pages; contains vii, 264 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 196-260).

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Keyworth, Helen. "Nicotine addiction : behavioural and neurochemical mechanisms." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606818.

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Few attempts "to quit smoking are successful, making current interventions relatively ineffective. Evidence shows that exercise decreases nicotine withdrawal symptoms in humans, but the mechanism is unclear. Part of this thesis aimed to explore the mechanisms underpinning the effect of exercise on nicotine withdrawal in both human and animal models of nicotine addiction. The role of perception of exercise intensity was investigated in temporarily abstinent smokers. Perceived and objective moderate intensity exercise and passive waiting all reduced withdrawal symptoms, and salivary cortisol was

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Millen, D. Leslie C. "The recovery of nicotine from tobacco." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356893.

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Hahn, Britta. "Mechanisms of nicotine-induced attentional enhancement." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400578.

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Wood, Teresa Lynne. "Biobehavioral aspects of adolescent nicotine dependence /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486401895209856.

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Asgaard, Gregory L. "Modulation of affective priming by nicotine /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1456288431&sid=4&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Pashmi, Ghazaleh. "Immunotherapy approach to combat nicotine addiction." Thesis, University of Bath, 2004. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419340.

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Smoking is now recognized as the single largest avoidable cause of premature death and disability in Britain and probably the greatest avoidable threat to public health worldwide. There are several therapies available to combat nicotine addiction ranging from psychological therapy to pharmacological interventions such as Nicotine Replacement Therapy. However, success rates for these therapies individually and mixture of therapies together, are still low and can be improved. A new strategy in helping quit rates is immunotherapy. This research project has focused on targeting cotinine, the major

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Alkhlaif, Yasmin. "IMPACT OF CHEMOTHERAPY ON NICOTINE DEPENDENCE." VCU Scholars Compass, 2017. https://scholarscompass.vcu.edu/etd/5175.

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Although cigarette smoke has been implicated in a causal relationship with various types of cancers, around 62% of all cancer patients are current smokers, recent quitters, or former smokers. While most patients who are smokers are motivated to quit after cancer diagnosis, 25 -30% of these patients continue to smoke. Furthermore, most quitters relapse after 2-3 years of post-chemotherapy. This represents a major health concern since several clinical studies revealed that perpetuation of smoking in cancer populations attenuates patient's well-being and quality of life. Smoking may impair healin

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44

Buelow, Melissa T. "The Influence of Nicotine Craving and Personality Characteristics on Risky Decision Making in Nicotine Dependent College Students." Ohio University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1246932131.

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Kleykamp, Betha A. "The Effects of Transdermal Nicotine on Tobacco/Nicotine Withdrawal and Concurrently Administered Cigarettes in Women and Men." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd/1218.

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Transdermal nicotine (TN) is a smoking cessation pharmacotherapy thought to work by suppressing tobacco/nicotine withdrawal and reducing the effect of a concurrently smoked tobacco cigarette. Clinical trials suggest that TN may be less efficacious for women. This study explored the possibility of gender differences in response to transdermal nicotine in 54 women and 70 men. Participants completed four within-subject, double-blind, randomized sessions corresponding to 0, 7, 14, and 21 mg TN and 4-hrs after TN application smoked an own-brand cigarette. Prior to session onset participants complet

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Hiler, Marzena M. "Electronic Cigarette User Plasma Nicotine Concentration and Puff Topography: Influence of Liquid Nicotine Concentration and User Experience." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4613.

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Electronic cigarettes (ECIGs) aerosolize an often nicotine-containing solution for user inhalation. ECIG nicotine delivery may depend on liquid nicotine concentration and user puffing behavior (topography). This study examined the relationship among liquid nicotine concentration, puff topography, and plasma nicotine concentration. Thirty-three ECIG-experienced and 31 ECIG-naïve individuals completed four laboratory sessions that differed by ECIG liquid nicotine concentration (0, 8, 18, or 36 mg/ml). A 3.3 volt “eGo” ECIG battery attached to a 1.5 Ohm dual coil “cartomizer” filled with 1 ml of

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Maier, Sheila Irene Bridget. "Melatonin receptor knockout mice have an increased physiological reaction to nicotine and increased voluntary oral nicotine consumption." Connect to online resource, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1453515.

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Windvogel, Shantal Lynn. "An investigation into the effect of maternal exposure to nicotine and copper on neonatal lung development." Thesis, University of the Western Cape, 2006. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_3411_1194336120.

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<p>In the 20th century, where tobacco smoking continues to be the leading preventable cause of death, an alarming number of people continue to smoke, despite awareness of the implications of exposure for themselves and those around them. Campaigns for the promotion of effective tobacco legislation and awareness are continuously being confronted by the tobacco industry's reluctance to put the health of their consumers before company profits, leading to a ripple effect of misinformation, serious health risks and economic implications, at least for the consumers. Pregnant women are especially a c

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Freitas, André Luiz Nunes. "A susceptibilidade à nicotina e etanol é afetada pela exposição à nicotina, fumaça de cigarro e etanol durante o período gestacional: alterações comportamentais e eletrofisiológicas no período pós-natal de camundongos." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8575.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>Uma questão particularmente relevante é o fato de exposições precoces a drogas de abuso durante o desenvolvimento potencialmente aumentarem a susceptibilidade a estas drogas posteriormente durante o desenvolvimento. No presente estudo utilizando estudos comportamentais e eletrofisiológicos, investigamos efeitos tardios da exposição de camundongos à fumaça de cigarro, à nicotina e ao etanol durante o período que corresponde à gestação em humanos. Para tal, esta tese foi dividida em 2 estudos. No Estudo 1, submetemos camundongos du

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Manzano, Beatriz Martins. "Variabilidade da frequência cardíaca como ferramenta de análise da função autonômica de tabagistas : revisão de literatura e estudo do plot de Poincaré /." Presidente Prudente : [s.n.], 2009. http://hdl.handle.net/11449/87320.

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Orientador: Dionei Ramos<br>Banca: Moacir Fernandes de Godoy<br>Banca: Ercy Mara Cipulo Ramos<br>Resumo: O tabagismo é considerado um dos principais fatores de risco modificáveis de doenças cardiovasculares e suas complicações, dentre as quais doença vascular aterosclerótica, hipertensão, infarto do miocárdio, angina instável e morte súbita. Os efeitos cardiovasculares promovidos pela nicotina ocorrem principalmente, devido ao aumento da atividade simpática, decorrente do estímulo de liberação de catecolaminas, por meio da ativação dos receptores nicotínicos localizados nas terminações nervosa

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