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Journal articles on the topic 'Next Generation Rating Approach'

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Author: Grafiati

Published: 10 December 2022

Last updated: 28 January 2023

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1

Ragonese, Egidio, Nunzio Spina, Alessandro Parisi, and Giuseppe Palmisano. "A CMOS Data Transfer System Based on Planar RF Coupling for Reinforced Galvanic Isolation with 25-kV Surge Voltage and 250-kV/µs CMTI." Electronics 9, no. 6 (June 5, 2020): 943. http://dx.doi.org/10.3390/electronics9060943.

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This paper exploits an effective approach to overcome the breakdown limitations of traditional galvanic isolators based on chip-scale isolation barriers, thus achieving a very high isolation rating (i.e., compliant with the reinforced isolation requirements). Such an approach is based on radio frequency (RF) planar coupling between two side-by-side co-packaged chips. Standard packaging along with proper assembling techniques can be profitably used to go beyond 20-kV surge voltage without using expensive or exotic isolation components. As a proof of concept, a bidirectional data transfer system based on RF planar coupling able to withstand an isolation rating as high as 25 kV has been designed in a low-cost standard 0.35-µm CMOS technology. Experimental measurements demonstrated a maximum data rate of 40 Mbit/s using a carrier frequency of about 1 GHz. The adopted approach also guarantees a common mode transient immunity (CMTI) of 250 kV/µs, which is a first-rate performance in view of next generation galvanic isolators for wide-bandgap power semiconductor devices, such as gallium nitride high-electron mobility transistors (GaN HEMTs) and silicon carbide (SiC) MOSFETs.

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Javidsharifi, Mahshid, Hamoun Pourroshanfekr, Tamas Kerekes, Dezso Sera, Sergiu Spataru, and Josep M. Guerrero. "Optimum Sizing of Photovoltaic and Energy Storage Systems for Powering Green Base Stations in Cellular Networks." Energies 14, no. 7 (March 29, 2021): 1895. http://dx.doi.org/10.3390/en14071895.

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Satisfying the mobile traffic demand in next generation cellular networks increases the cost of energy supply. Renewable energy sources are a promising solution to power base stations in a self-sufficient and cost-effective manner. This paper presents an optimal method for designing a photovoltaic (PV)-battery system to supply base stations in cellular networks. A systematic approach is proposed for determining the power rating of the photovoltaic generator and battery capacity from a technical and economical point of view in order to minimize investment cost as well as operational expenditure, while the power autonomy of the PV-battery system is maximized in a multi-objective optimization framework. The proposed method is applied to optimally size a photovoltaic-battery system for three cases with different availability of solar power to investigate the effect of environmental conditions. Problem-solving using the proposed approach leads to a set of solutions at different costs versus different levels of power autonomy. According to the importance of each criterion and the preference of decision-makers, one of the achieved solutions can be selected for the implementation of the photovoltaic-battery system to supply base stations in cellular networks.

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Firdaus, Muhammad, Sandi Rahmadika, and Kyung-Hyune Rhee. "Decentralized Trusted Data Sharing Management on Internet of Vehicle Edge Computing (IoVEC) Networks Using Consortium Blockchain." Sensors 21, no. 7 (March 31, 2021): 2410. http://dx.doi.org/10.3390/s21072410.

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The emergence of the Internet of Vehicles (IoV) aims to facilitate the next generation of intelligent transportation system (ITS) applications by combining smart vehicles and the internet to improve traffic safety and efficiency. On the other hand, mobile edge computing (MEC) technology provides enormous storage resources with powerful computing on the edge networks. Hence, the idea of IoV edge computing (IoVEC) networks has grown to be an assuring paradigm with various opportunities to advance massive data storage, data sharing, and computing processing close to vehicles. However, the participant’s vehicle may be unwilling to share their data since the data-sharing system still relies on a centralized server approach with the potential risk of data leakage and privacy security. In addition, vehicles have difficulty evaluating the credibility of the messages they received because of untrusted environments. To address these challenges, we propose consortium blockchain and smart contracts to accomplish a decentralized trusted data sharing management system in IoVEC. This system allows vehicles to validate the credibility of messages from their neighboring by generating a reputation rating. Moreover, the incentive mechanism is utilized to trigger the vehicles to store and share their data honestly; thus, they will obtain certain rewards from the system. Simulation results substantially display an efficient network performance along with forming an appropriate incentive model to reach a decentralized trusted data sharing management of IoVEC networks.

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Ambrosi, Elisa, Federica Canzan, Alessandra Zenere, Mario Grassi, Stefano Tardivo, Luigina Mortari, Luisa Saiani, and Elisabetta Zanolin. "Developing a new questionnaire to measure nurse caring behaviours: a mixed method study." European Journal for Person Centered Healthcare 6, no. 3 (September 28, 2018): 405. http://dx.doi.org/10.5750/ejpch.v6i3.1517.

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Rationale, aims and objective: Measuring nurse caring may provide empirical evidence to assist clinicians and administrators in making decisions. The aim of the present study was to develop a new scale, called the CARE-Italy, grounded in the Italian culture, for measuring nurses’ caring behaviours.Methods: A mixed method approach was applied in developing the instrument. The item generation and scale development were performed through a qualitative phenomenological approach and a focus group with a panel of experts. The provisional instrument was then administered to a convenience sample of 439 nurses and then questionnaire scaling and association analysis were performed. A dual scaling analysis of successive categories was performed to identify preferences on the rating scale. An item selection based on item-scale correlations and item weights was performed. Subjects’ mean scores were computed and standardized in a 100-point scale.Results: The 20 caring behaviours perceived by nurses to be the most important ones constitute the final version of the CARE-Italy questionnaire. They concern patients’ surveillance, professional relationships with patients, satisfying patients’ and family members’ practical and psychological needs, team consultation and nurses’ emotions.Conclusions: A relational and paternalistic caring approach by Italian nurses seems to be suggested. The next step of the research project will be the validation process of the CARE-Italy questionnaire with a Likert scale measuring the occurrence of the 20 caring behaviours in daily practice.

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Giordano, Ilaria, Florian Harmuth, Heike Jacobi, Brigitte Paap, Stefan Vielhaber, Judith Machts, Ludger Schöls, et al. "Clinical and genetic characteristics of sporadic adult-onset degenerative ataxia." Neurology 89, no. 10 (August 9, 2017): 1043–49. http://dx.doi.org/10.1212/wnl.0000000000004311.

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Objective:To define the clinical phenotype and natural history of sporadic adult-onset degenerative ataxia and to identify putative disease-causing mutations.Methods:The primary measure of disease severity was the Scale for the Assessment and Rating of Ataxia (SARA). DNA samples were screened for mutations using a high-coverage ataxia-specific gene panel in combination with next-generation sequencing.Results:The analysis was performed on 249 participants. Among them, 83 met diagnostic criteria of clinically probable multiple system atrophy cerebellar type (MSA-C) at baseline and another 12 during follow-up. Positive MSA-C criteria (4.94 ± 0.74, p < 0.0001) and disease duration (0.22 ± 0.06 per additional year, p = 0.0007) were associated with a higher SARA score. Forty-eight participants who did not fulfill MSA-C criteria and had a disease duration of >10 years were designated sporadic adult-onset ataxia of unknown etiology/non-MSA (SAOA/non-MSA). Compared with MSA-C, SAOA/non-MSA patients had lower SARA scores (13.6 ± 6.0 vs 16.0 ± 5.8, p = 0.0200) and a slower annual SARA increase (1.1 ± 2.3 vs 3.3 ± 3.2, p = 0.0013). In 11 of 194 tested participants (6%), a definitive or probable genetic diagnosis was made.Conclusions:Our study provides quantitative data on the clinical phenotype and progression of sporadic ataxia with adult onset. Screening for causative mutations with a gene panel approach yielded a genetic diagnosis in 6% of the cohort.ClinicalTrials.gov registration:NCT02701036.

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Jamsek, S., S. Tot, M. Lasić, I. Periša, and M. Miklavcic. "REGIONALY IMPORTANT SINCRO.GRID SMART GRID PROJECT." Journal of Energy - Energija 67, no. 2 (June 2, 2022): 86–91. http://dx.doi.org/10.37798/201867283.

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Regional transmission and distribution challenges has evolved and changed a lot in recent years. Four contradictory influences increasingly affected the operations of Slovenian and Croatian electricity systems. Regional electricity systems experienced increasing support of RES integration to meet the EU targets, a lower electricity consumption due to the economic crisis, a growing lack of centralized electricity production for electric system support and the high interconnectivity between the neighboring control zones. TSOs and DSOs observed growing network overvoltage issues as well as a decrease in secondary reserve capacities. Such situation starts to impact national and regional renewable integration targets affecting the security of supply at European level. SINCRO.GRID joint investment project addressed the above-mentioned issues in a sustainable manner. Such cross-border systemic approach will bring synergetic benefits. It will enable an acceptable level of security of operation for at least the next ten years hosting levels of RES in line with the trends foreseen to reach the 2030 targets safely. The project is going to integrate new active elements in the transmission and distribution grids. It leans on the following main pillars: deployment of six compensation devices, deployment of advanced dynamic thermal rating (DTR) systems, deployment of electricity storage systems, integration of distributed renewable generation (DG) and deployment of a virtual cross-border control center (VCBCC). A key aspect of the SINCRO.GRID project lies in the synergy brought by the simultaneous innovative deployment of a portfolio of mature technology-based solutions bring high benefits and positive externalities for the region and European Union.

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Clements-Croome, Derek. "The role of feedback in building design 1980–2018 and onwards." Building Services Engineering Research and Technology 40, no. 1 (November 9, 2018): 5–12. http://dx.doi.org/10.1177/0143624418812982.

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This is a paper updating the paper I wrote on this topic for BSERT in issue 1 volume 1 in 1980. The original paper set out the causes of failure in building design as being due to various issues such as an inadequate brief, lack of data, poor communication, inadequate analysis or synthesis, quirks of human behaviour which could all contribute. Systematic appraisal – now referred to as post-occupancy evaluation – of buildings in use provides feedback which helps us to understand why theory and practice do not always agree and also gives evidence for improved building economics. It concluded that we have to involve users more in the design of buildings, and for the next generations, we need a much broader based education of building designers. This paper continues the theme by considering the latest methods of measurement and assessment which provide feedback data for sustainability but focusing more on health and wellbeing rating assessments. Practical application: Our professions need more interaction across sectors and to foster a transdisciplinary approach. This means more communication with other professional kinsmen from the health and wellbeing sectors in order to make valuable interventions in the building design process. This paper updates the 1980 paper from the first edition of BSER&T that sets out the causes of failure in building design as being due to various issues such as an inadequate brief, lack of data, poor communication, inadequate analysis or synthesis, quirks of human behaviour which could all contribute. The paper determines that the need for feedback in order to improve building performance and provide data to develop existing guidelines, codes and standards is as valid now as it was in 1980 but the way we do this has changed.

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Nakazawa, Keisuke, Toshio Onodera, and Masaru Sasago. "Approach to Next-Generation Optical Lithography." Japanese Journal of Applied Physics 38, Part 1, No. 5A (May 15, 1999): 3001–2. http://dx.doi.org/10.1143/jjap.38.3001.

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Rubegni, Anna, Alessandro Malandrini, Claudia Dosi, Guja Astrea, Jacopo Baldacci, Carla Battisti, Giulia Bertocci, et al. "Next-generation sequencing approach to hyperCKemia." Neurology Genetics 5, no. 5 (August 16, 2019): e352. http://dx.doi.org/10.1212/nxg.0000000000000352.

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ObjectiveNext-generation sequencing (NGS) was applied in molecularly undiagnosed asymptomatic or paucisymptomatic hyperCKemia to investigate whether this technique might allow detection of the genetic basis of the condition.MethodsSixty-six patients with undiagnosed asymptomatic or paucisymptomatic hyperCKemia, referred to tertiary neuromuscular centers over an approximately 2-year period, were analyzed using a customized, targeted sequencing panel able to investigate the coding exons and flanking intronic regions of 78 genes associated with limb-girdle muscular dystrophies, rhabdomyolysis, and metabolic and distal myopathies.ResultsA molecular diagnosis was reached in 33 cases, corresponding to a positive diagnostic yield of 50%. Variants of unknown significance were found in 17 patients (26%), whereas 16 cases (24%) remained molecularly undefined. The major features of the diagnosed cases were mild proximal muscle weakness (found in 27%) and myalgia (in 24%). Fourteen patients with a molecular diagnosis and mild myopathic features on muscle biopsy remained asymptomatic at a 24-month follow-up.ConclusionsThis study of patients with undiagnosed hyperCKemia, highlighting the advantages of NGS used as a first-tier diagnostic approach in genetically heterogeneous conditions, illustrates the ongoing evolution of molecular diagnosis in the field of clinical neurology. Isolated hyperCKemia can be the sole feature alerting to a progressive muscular disorder requiring careful surveillance.

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Hawkins, R. David, Gary C. Hon, and Bing Ren. "Next-generation genomics: an integrative approach." Nature Reviews Genetics 11, no. 7 (June 8, 2010): 476–86. http://dx.doi.org/10.1038/nrg2795.

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BANBARA, MUTSUNORI, BENJAMIN KAUFMANN, MAX OSTROWSKI, and TORSTEN SCHAUB. "Clingcon: The next generation." Theory and Practice of Logic Programming 17, no. 4 (June 28, 2017): 408–61. http://dx.doi.org/10.1017/s1471068417000138.

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AbstractWe present the third generation of the constraint answer set systemclingcon, combining Answer Set Programming (ASP) with finite domain constraint processing (CP). While its predecessors rely on a black-box approach to hybrid solving by integrating the CP solvergecode, the newclingconsystem pursues a lazy approach using dedicated constraint propagators to extend propagation in the underlying ASP solverclasp. No extension is needed for parsing and groundingclingcon's hybrid modeling language since both can be accommodated by the new generic theory handling capabilities of the ASP groundergringo. As a whole,clingcon3 is thus an extension of the ASP systemclingo5, which itself relies on the groundergringoand the solverclasp. The new approach ofclingconoffers a seamless integration of CP propagation into ASP solving that benefits from the whole spectrum ofclasp's reasoning modes, including, for instance, multi-shot solving and advanced optimization techniques. This is accomplished by a lazy approach that unfolds the representation of constraints and adds it to that of the logic program only when needed. Although the unfolding is usually dictated by the constraint propagators during solving, it can already be partially (or even totally) done during preprocessing. Moreover,clingcon's constraint preprocessing and propagation incorporate several well-established CP techniques that greatly improve its performance. We demonstrate this via an extensive empirical evaluation contrasting, first, the various techniques in the context of CSP solving and, second, the newclingconsystem with other hybrid ASP systems.

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Samiullah, Muhammad, Waqar Aslam, Muhammad Asghar Khan, Haya Mesfer Alshahrani, Hany Mahgoub, Ako Muhammad Abdullah, M. Ikram Ullah, and Chien-Ming Chen. "Rating of Modern Color Image Cryptography: A Next-Generation Computing Perspective." Wireless Communications and Mobile Computing 2022 (March 22, 2022): 1–20. http://dx.doi.org/10.1155/2022/7277992.

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Issues such as inefficient encryption architectures, nonstandard formats of image datasets, weak randomness of chaos-based Pseudorandom Number Generators (PRNGs), omitted S-boxes, and unconvincing security metrics leading to increased computational time and inadequate security level of chaos and Deoxyribonucleic Acid- (DNA-) based image encryption schemes need careful examination towards the development of more stable encryption schemes in terms of efficiency and reasonable security. A new taxonomy of image encryption based on chaotic systems, hyperchaotic systems, and DNA is propounded to assess the impact of these issues on the performance and security metrics. The primary emphasis of this research is to study various recent encryption architectures centered on a variety of confusion and diffusion methods. It is aimed at assessing the performance and security of various ciphers using a cipher rating criterion that categorizes ciphers into different classes. The parameters that are included in the rating criteria are information entropy, chi-squared goodness of fit test for histogram uniformity analysis, encryption efficiency, key space, differential attacks (Number of Pixels Change Rate and Universal Average Changing Intensity), key sensitivity analysis, encryption time, randomness tests such as NIST-R (a statistical suite for validating the randomness designed by the National Institute of Standards and Technology), correlation coefficient analysis, contrast analysis, energy analysis, homogeneity analysis, Mean Absolute Error, peak signal-to-noise ratio, and robustness to noise and occlusion attacks.

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Matthijs, Gert, Erika Souche, Mariëlle Alders, Anniek Corveleyn, Sebastian Eck, Ilse Feenstra, Valérie Race, et al. "Guidelines for diagnostic next-generation sequencing." European Journal of Human Genetics 24, no. 1 (October 28, 2015): 2–5. http://dx.doi.org/10.1038/ejhg.2015.226.

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Abstract We present, on behalf of EuroGentest and the European Society of Human Genetics, guidelines for the evaluation and validation of next-generation sequencing (NGS) applications for the diagnosis of genetic disorders. The work was performed by a group of laboratory geneticists and bioinformaticians, and discussed with clinical geneticists, industry and patients’ representatives, and other stakeholders in the field of human genetics. The statements that were written during the elaboration of the guidelines are presented here. The background document and full guidelines are available as supplementary material. They include many examples to assist the laboratories in the implementation of NGS and accreditation of this service. The work and ideas presented by others in guidelines that have emerged elsewhere in the course of the past few years were also considered and are acknowledged in the full text. Interestingly, a few new insights that have not been cited before have emerged during the preparation of the guidelines. The most important new feature is the presentation of a ‘rating system’ for NGS-based diagnostic tests. The guidelines and statements have been applauded by the genetic diagnostic community, and thus seem to be valuable for the harmonization and quality assurance of NGS diagnostics in Europe.

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Alhomoud, Adeeb, Irfan Awan, Jules Ferdinand Pagna Disso, and Muhammad Younas. "A Next-Generation Approach to Combating Botnets." Computer 46, no. 4 (April 2013): 62–66. http://dx.doi.org/10.1109/mc.2013.67.

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Zhang, Qing Chun Jon, Jennifer Duc, Van Mieczkowski, Brett Hull, Scott Allen, and John W. Palmour. "4H-SiC Trench Schottky Diodes for Next Generation Products." Materials Science Forum 740-742 (January 2013): 781–84. http://dx.doi.org/10.4028/www.scientific.net/msf.740-742.781.

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A novel trench JBS structure has been developed to reduce the electrical field at the Schottky interface. Compared to the conventional planar JBS structure, the new design has reduced the reverse leakage current by 1 order of magnitude at rated voltage. The much reduced field at the Schottky interface allows an increase in the drift doping concentration, which enables a significant chip size reduction on next generation SiC Schottky diodes. This progress makes it possible to fabricate high current rating (>50 A) SiC diodes for module applications.

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Lim, Alane. "Modeling approach helps describe next-generation memory technologies." Scilight 2021, no. 49 (December 3, 2021): 491101. http://dx.doi.org/10.1063/10.0007476.

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Laustsen, Andreas H. "Toxin-centric development approach for next-generation antivenoms." Toxicon 150 (August 2018): 195–97. http://dx.doi.org/10.1016/j.toxicon.2018.05.021.

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Jain, Rupal, Sumit Chaudhary, and Rajendra Kumar. "Green Approach for Next Generation Computing: A Survey." International Journal of Advanced Engineering Research and Science 4, no. 1 (2016): 78–82. http://dx.doi.org/10.22161/ijaers.4.1.12.

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Berthelot, S., E. Lang, M. Émond, M. Mallet, H. T. Stelfox, R. Lavergne, F. Légaré, et al. "GD02: An international consensus study to identify quality indicators for ambulatory emergency care." CJEM 19, S1 (May 2017): S62—S63. http://dx.doi.org/10.1017/cem.2017.162.

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Introduction: Redirecting low acuity patients from emergency departments to primary care walk-in clinics has been identified as a priority by many health authorities. Promoting family physicians for the management of ambulatory patients with urgent health concerns reflects the assumption that primary care facilities can offer high-quality and more affordable ambulatory emergency care. However, no performance assessment framework has been developed for ambulatory emergency care and consequently, quality of care provided in these alternate settings has never been formally compared. Primary objective: To identify structure, process and outcome indicators for ambulatory emergency care. Methods: We will identify and develop quality indicators (QIs) for ambulatory emergency care using a RAND/UCLA Appropriateness Method (RAM) composed of three different steps. First, we will perform a scoping literature review to inventory 1) all previously recommended QIs assessing care provided to ambulatory emergency patients in the ED or the primary care settings; 2) all conditions evaluated with the retrieved QIs; and 3) all outcomes measured by the same QIs. Second, a steering committee composed of the research team and of international experts in performance assessment in emergency and primary care will be presented with the lists of QI-related conditions and outcomes. They will be asked to identify potential outcome indicators for ambulatory emergency care by generating any relevant combinations of one condition and one outcome (e.g. acute asthma exacerbation/re-consultation). Committee members will be given the latitude to use and pair any conditions or outcomes not included in the lists as long as they think the resulting indicators are compatible with the study objectives. Using a structured nominal group approach, they will combine their suggestions and refine the list of potential QIs. This list of potential outcome indicators composed of pairs “condition/outcome” will be merged with the list of already published QIs identified during the literature review. Third, as per the RAM standards, we will assemble an international multidisciplinary panel (n=20) of patients, emergency and primary care providers, researchers and decision makers, after recommendations from international emergency and primary care associations, and from the Canadian Strategy for Patient-Oriented Research (SPOR) Support Units. Through iterative rounds of ratings using both web-based survey tools and videoconferencing, panelists will independently assess all candidate QIs. They will be asked to rate on a nine-level scale to what extent each QI is a relevant and useful measure of ambulatory emergency care quality. From one round to the next, QIs with a median panelist rating score of one to three will be excluded. Those with a median score of seven or more will be automatically included in the final list. QIs with median score of four to six will be retained for future deliberations among the panelists. Rounds of ratings will be conducted until all QIs are classified. Impact: The QIs identified will be used to develop a performance assessment framework for ambulatory emergency care. This will represent an essential step toward testing the assumption that EDs and primary care walk-in clinics provide equivalent care quality to low acuity patients.

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Hurford, Amy, Daniel Cownden, and Troy Day. "Next-generation tools for evolutionary invasion analyses." Journal of The Royal Society Interface 7, no. 45 (December 2, 2009): 561–71. http://dx.doi.org/10.1098/rsif.2009.0448.

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Evolutionary invasion analysis is a powerful technique for modelling in evolutionary biology. The general approach is to derive an expression for the growth rate of a mutant allele encoding some novel phenotype, and then to use this expression to predict long-term evolutionary outcomes. Mathematically, such ‘invasion fitness’ expressions are most often derived using standard linear stability analyses from dynamical systems theory. Interestingly, there is a mathematically equivalent approach to such stability analyses that is often employed in mathematical epidemiology, and that is based on so-called ‘next-generation’ matrices. Although this next-generation matrix approach has sometimes also been used in evolutionary invasion analyses, it is not yet common in this area despite the fact that it can sometimes greatly simplify calculations. The aim of this article is to bring the approach to a wider evolutionary audience in two ways. First, we review the next-generation matrix approach and provide a novel, and easily intuited, interpretation of how this approach relates to more standard techniques. Second, we illustrate next-generation methods in evolutionary invasion analysis through a series of informative examples. Although focusing primarily on evolutionary invasion analysis, we provide several insights that apply to biological modelling in general.

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Volk, Mojca, Janez Sterle, Urban Sedlar, and Andrej Kos. "An approach to modeling and control of QoE in next generation networks [Next Generation Telco IT Architectures." IEEE Communications Magazine 48, no. 8 (August 2010): 126–35. http://dx.doi.org/10.1109/mcom.2010.5534597.

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Cooke, Mike, and Phyllis Macfarlane. "Training the Next Generation of Market Researchers." International Journal of Market Research 51, no. 3 (January 2009): 1–16. http://dx.doi.org/10.1177/147078530905100311.

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GfK NOP is seeking to develop excellence through the use of Web 2.0 tools on its graduate training programme. Our approach has been to build excellence by adopting a new organisational form known as the ‘community of practice’ approach. This approach is emerging in companies that seek excellence as it promises to galvanise knowledge sharing, learning and change. It has led them into a world where the avatar has been conducting interviews in Second Life and they have been using social networks for research purposes. It is believed this approach will produce market researchers who are more attuned to client requirements of the future, and could possibly retain more talent within the industry, as it allows new entrants to see how they can contribute to the development of methods, techniques and products, and creates a better sense of belonging to the industry.

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Saeki, Hiroshi. "Approach of the Gastrointestinal Surgery for the Next Generation." Kitakanto Medical Journal 71, no. 2 (May 1, 2021): 153–54. http://dx.doi.org/10.2974/kmj.71.153.

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Kumar, K. B. M. Pavan. "An Interactive Approach to the Next Generation Quantum Computing." International Journal for Research in Applied Science and Engineering Technology 8, no. 2 (February 29, 2020): 393–98. http://dx.doi.org/10.22214/ijraset.2020.2060.

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Scheller, Johannes, Gurvan Jodin, Karl Joseph Rizzo, Eric Duhayon, Jean François Rouchon, Michael Triantafyllou, and Marianna Braza. "A Combined Smart-Materials Approach for Next-Generation Airfoils." Solid State Phenomena 251 (July 2016): 106–12. http://dx.doi.org/10.4028/www.scientific.net/ssp.251.106.

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This article will present a morphing wing actuated using both surface embedded Shape memory alloys (SMAs) and trailing edge Macro-fiber composites (MFCs). This combination enables the airfoil to simultaneously achieve large scale deformations at low frequencies as well as rapid actuation with a limited amount of displacement. Thereby not only can the shape of the airfoil be optimized in function of the current mission profile but also the shear layer can be influenced. Each actuator is modelled using both a finite element and/or an analytical model and the results will be verified experimentally.

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Sohul, Munawwar M., Miao Yao, Xiaofu Ma, Eyosias Y. Imana, Vuk Marojevic, and Jeffrey H. Reed. "Next generation public safety networks: A spectrum sharing approach." IEEE Communications Magazine 54, no. 3 (March 2016): 30–36. http://dx.doi.org/10.1109/mcom.2016.7432144.

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Alkhateeb, Abedalrhman, and Luis Rueda. "Zseq: An Approach for Preprocessing Next-Generation Sequencing Data." Journal of Computational Biology 24, no. 8 (August 2017): 746–55. http://dx.doi.org/10.1089/cmb.2017.0021.

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Fuchs, Douglas, Lynn S. Fuchs, and Donald L. Compton. "Smart RTI: A Next-Generation Approach to Multilevel Prevention." Exceptional Children 78, no. 3 (April 2012): 263–79. http://dx.doi.org/10.1177/001440291207800301.

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Ren, Hong, Nan Liu, Cunhua Pan, Maged Elkashlan, Arumugam Nallanathan, Xiaohu You, and Lajos Hanzo. "Low-Latency C-RAN: An Next-Generation Wireless Approach." IEEE Vehicular Technology Magazine 13, no. 2 (June 2018): 48–56. http://dx.doi.org/10.1109/mvt.2018.2811244.

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Dhaliwal, R. S., W. A. Enichen, S. D. Golladay, M. S. Gordon, R. A. Kendall, J. E. Lieberman, H. C. Pfeiffer, et al. "PREVAIL—Electron projection technology approach for next-generation lithography." IBM Journal of Research and Development 45, no. 5 (September 2001): 615–38. http://dx.doi.org/10.1147/rd.455.0615.

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Van Impe, Jan F., Dominique Vercammen, and Eva Van Derlinden. "Developing next generation predictive models: a systems biology approach." Procedia Food Science 1 (2011): 965–71. http://dx.doi.org/10.1016/j.profoo.2011.09.145.

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Choudhury, N. H., and S. N. Gupta. "Next Generation Approach to Solve Interconnection Problem in Bangladesh." IETE Technical Review 23, no. 6 (November 2006): 367–74. http://dx.doi.org/10.1080/02564602.2006.11657968.

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Yuan, Linwang, Zhaoyuan Yu, and Wen Luo. "Towards the next-generation GIS: a geometric algebra approach." Annals of GIS 25, no. 3 (May 13, 2019): 195–206. http://dx.doi.org/10.1080/19475683.2019.1612945.

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Auclair, Daniel, Mark Bustoros, MD, Carrie Cibulskis, Teni Dowdell, Svetlana Gavrilov, Cody J. Boehner, Jennifer Yesil, et al. "A Next Generation Liquid Biopsy Approach for Multiple Myeloma." Blood 136, Supplement 1 (November 5, 2020): 33. http://dx.doi.org/10.1182/blood-2020-136865.

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Direct-to-Patient (DTP) Multiple Myeloma (MM) research studies have been launched recently, including PCROWD (NCT02269592), PROMISE (NCT03689595) and the MMRF CureCloud Research Initiative (NCT03657251), aimed at enrolling thousands of individuals from whom comprehensive molecular and immune analyses will be generated from blood specimens and the resulting data aggregated with the correlating clinical information. To support the molecular characterization of liquid biopsies for such DTP efforts, a set of myeloma-specific liquid biopsy approaches were developed. First, a hybrid selection panel was developed that detects somatic variants present in a patient's circulating-free DNA (cfDNA) in 70 commonly altered MM and Clonal Hematopoiesis of Indeterminate Potential (CHIP) genes. For this MM 70-Gene cfDNA Assay, samples are received as blood in a StreckTM tube designed for stabilization of cfDNA and DNA is extracted from buffy coat using magnetic bead-based chemistry. Deep coverage sequencing (80,000x depth) is performed and duplex BAM files generated with UMI alignment and error correction allowing for sensitive detection of clinically relevant variants. Technical validation data on healthy donor cfDNA mixes was generated using samples with a range of cfDNA inputs. This data determined that the assay is capable of achieving >90% sensitivity for detecting somatic events present at 1% variant allele frequency with a specificity of <0.2 false positives per megabase. Using a clinical cohort, we observed a strong correlation between Bone Marrow Aspirate (BMA) and cfDNA samples with the vast majority of variants previously detected in BMA also identified via the MM-70 Gene panel analysis. Interestingly, we also saw evidence of additional somatic variants identified in cfDNA previously undetected in BMA analysis. Because one the aims of this effort is to return results to treating physicians, a clinical-grade (CLIA) pipeline was established. For that CLIA pipeline, the variants reported are a subset of all the events detected by the MM 70-Gene Assay. The events detected in the assay are reviewed by experienced molecular pathologists at the Dana Farber Cancer Institute (DFCI) who have developed a customized reporting process. These reports utilize an internally-developed knowledgebase of variant/gene annotations that leverages the DFCI expertise in hematologic malignancies and myeloma specifically. The reports are then provided back through providers to the patient via the CureCloud system for their use in clinical care and trial identification. In order to complement the MM-70 Gene panel with copy number and translocation information, we have been exploring Circulating Multiple Myeloma Cells (CMMCs). Our current approach involves automated capture of CMMCs using ferrofluids coated with MM-selective and discriminating antibodies to immunomagnetically enrich circulating plasma cells. The highly enriched CMMCs fractions generated in such a fashion are then submitted for molecular characterization. At the submission date of this abstract, 163 patients have been fully enrolled into CureCloud from which results will be presented. In summary, we have developed a robust and very sensitive clinical-grade next-gen liquid biopsy sequencing platform allowing for minimally invasive monitoring of MM disease genomics that can be used to complement other more classical approaches and to help support our Direct-To-Patient Initiatives. Especially in this post-COVID19 era, such liquid biopsy-based approaches that avoid clinic visits for the patients and can be performed through at-home mobile phlebotomy are emerging as important new options. Disclosures Kim: LabCorp: Consultancy; Quanterix, Inc: Consultancy; PapGene, Inc: Consultancy. Ghobrial:AbbVie: Consultancy; GNS Healthcare: Consultancy; GlaxoSmithKline: Consultancy; Genentech: Consultancy; Noxxon Pharma: Consultancy; Novartis: Consultancy; Adaptive Biotechnologies: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Bristol-Myers Squibb: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Takeda: Consultancy, Honoraria; Cellectar: Honoraria; Karyopharm Therapeutics: Consultancy, Honoraria; Amgen: Consultancy, Honoraria.

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Levis, Mark J., Wenge Shi, Ken CN Chang, Christian Laing, Flora Berisha, Emily Adams, Christopher D. Gocke, et al. "Development of a Novel Next-Generation Sequencing (NGS)-Based Assay for Measurable Residual Disease (MRD) in FLT3-ITD AML and Its Potential Clinical Application in Patients Treated with Chemotherapy Plus FLT3 Inhibitors." Blood 132, Supplement 1 (November 29, 2018): 1459. http://dx.doi.org/10.1182/blood-2018-99-110438.

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Abstract The presence of MRD in patients with acute myeloid leukemia (AML) who are in morphologic remission has been shown to be a powerful predictor of eventual relapse. FMS-like tyrosine kinase 3 internal tandem duplications (FLT3-ITD) confer a negative prognostic impact by increasing the risk of relapse. However, the ability to detect these mutations in remission bone marrow specimens is hampered by the limited sensitivity of conventional polymerase chain reaction (PCR)-based assays, which detect approximately only 1 of every 100 (1%) mutant cells. To address this problem, we have developed a novel NGS-based MRD assay for the detection of FLT3-ITD mutations. Using isolated genomic DNA from bone marrow aspirates or whole-blood samples, PCR primers flanking exons 14 and 15 of the FLT3 gene were designed and highly diverse NGS libraries were generated. These libraries were then sequenced by Illumina's sequencing-by-synthesis method. The bioinformatics approach we used identifies unique FLT3-ITD mutations of varying length along with wild type sequences and calculates a mutant allelic frequency. The assay was validated using clinical samples to assess accuracy and reproducibility. DNA samples from selected mutant cell lines representing different FLT3-ITD lengths were spiked into normal DNA to evaluate assay sensitivity and linearity. The assay was linear (R2 = 0.958) down to FLT3-ITD allele frequency levels of 0.035% but was capable of detecting FLT3-ITD mutations at a level as low as 0.003%. We next validated the assay using clinical samples from patients with FLT3-ITD AML. The negative prognostic impact of FLT3-ITD mutations can be mitigated in part when an FLT3 inhibitor is administered in combination with induction chemotherapy, as demonstrated in CALGB10603/RATIFY (N Engl J Med. 2017;377:454). It was reported in this study that patients treated with an FLT3 inhibitor combined with chemotherapy followed by allogeneic transplant in first remission had better overall survival than their counterparts in the control arm. One hypothesis for this outcome is that the FLT3-inhibitor-treated patients had a lower leukemic burden prior to transplant. As a pilot test of this concept, we used our MRD assay on a series of bone marrow aspirate samples collected from 10 patients with newly diagnosed FLT3-ITD AML. The patients were selected to be as uniform as possible. All patients had intermediate-risk karyotype, a detectable FLT3-ITD mutation by conventional PCR, and mutated NPM1. All patients received cytarabine-based intensive induction and achieved morphologic first remission with a single course of chemotherapy. Finally, all patients underwent allogeneic transplant in first remission. The sample analyzed for MRD was the first collected after remission induction, 5-8 weeks after the start of therapy. The investigators performing the MRD assay were blinded to the clinical data. Four patients received chemotherapy alone, while 6 were treated with chemotherapy (7+3) plus an FLT3 inhibitor. In all patients' remission samples, the MRD assay identified the FLT3-ITD mutation that precisely matched the one observed in the original diagnostic specimen. This demonstrates the sensitivity of the assay (all samples had a detectable mutation), and the unique length of each patient's mutation confers a degree of specificity not achievable with MRD detection methods that focus on other AML-associated mutations. Supporting our hypothesis was the observation that patients treated with FLT3 inhibitors had MRD levels lower than those in patients treated with chemotherapy alone (Figure). Our results help establish the role of NGS-based MRD assays for the clinical management of FLT3-ITD AML. This assay could be used to define the depth of remission, identify persistent disease, and help guide decision making in the use of FLT3 inhibitors as continuation therapy. This study provides validation of the clinical utility of our MRD assay, which will be used to analyze the remission samples from patients in the ongoing phase 3, randomized, double-blind, placebo-controlled QuANTUM-First clinical trial, in which patients with newly diagnosed FLT3-ITD AML are randomized to receive either the highly potent and selective FLT3 inhibitor quizartinib or placebo in combination with chemotherapy, followed by single-agent quizartinib as continuation therapy. Disclosures Shi: Novartis: Employment, Equity Ownership; Daiichi Sankyo: Other: Provide clinical trial testing services. Chang:Daiichi Sankyo: Employment. Laing:Novartis: Employment; Daiichi Sankyo: Other: Provide clinical trial testing services. Berisha:Daiichi Sankyo: Employment. Adams:Johns Hopkins University: Employment. Ding:Navigate BP: Employment; Daiichi Sankyo: Other: Provide clinical trial testing services. Nakamaru:Daiichi Sankyo: Employment. Lameh:Navigate BioPharma Inc,: Employment; Daiichi Sankyo: Other: Provide clinical trial testing services. Pollner:Navigate BioPharma Inc.: Employment. Kobayashi:Daiichi Sankyo: Employment.

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Bech, P., M. Kastrup, and D. Loldrup. "Use of Headache Rating Scales: A Multiaxial Approach." Cephalalgia 6, no. 2 (June 1986): 69–80. http://dx.doi.org/10.1046/j.1468-2982.1986.0602069.x.

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The basic principles of the rating scale procedure have been outlined, including the Likert scale, the Guilford criteria for item definitions, and the Guttman and Rasch criteria for item combinations. With these criteria, headache rates among the core symptoms of anxiety and depression. Next, we have discussed one of the prevailing scales for headache, the Waters Headache Questionnaire (WHQ), with a multiaxial approach. The WHQ thus contains a severity axis, a diagnostic axis, and a personality axis. Previous studies on the validity of the WHQ, including factor analysis, have shown that migraine and muscular headaches are not mutually exclusive categories. Studies to validate a two-dimensional diagnostic system of migraine and non-migraine headache by Rasch models are discussed. In the field of personality it was suggested, when using questionnaires like the WHQ, to focus on the concepts of acquiescence and dissimulation. Supplemental axes such as “severity of psychosocial stressors” and “social functioning” or “quality of life” should be considered in future research.

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Hsiao-Hwa Chen, Shin-Wei Chu, and M. Guizani. "On Next Generation CDMA Technologies: The REAL Approach for Perfect Orthogonal Code Generation." IEEE Transactions on Vehicular Technology 57, no. 5 (September 2008): 2822–33. http://dx.doi.org/10.1109/tvt.2007.914055.

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Femi, R., Shibu Clement, Anita Agrawal, and A. Amalin Prince. "Investigation of Microelectromechanical Switches for Next Generation DC Power Distribution System." International Journal of Emerging Electric Power Systems 15, no. 6 (December 1, 2014): 591–605. http://dx.doi.org/10.1515/ijeeps-2014-0042.

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Abstract This paper investigates the application of microelectromechanical system (MEMS) switches for DC power distribution system. Traditional electromechanical switches, solid state switches and solid state switch array are studied and simulated to understand their characteristics. Performance and characteristics of MEMS switches are reviewed and identified that electrostatically actuated MEMS switches are suitable for DC power applications. Scalable total cross tied (TCT) array configuration using MEMS switches has been proposed. The proposed configuration is suitable for variable voltage/current rating. Arc-less behavior of the switch configuration is analyzed using modified Paschen’s curve. 400 V/6 A system is considered for the simulation and comparative study. The simulated result of the proposed MEMS switch array configuration is compared with the traditional switches. The comparative study shows that the proposed switch array configuration gives better performance in terms of voltage drop, leakage current, power loss, arc and size. This can be used in DC power system protection, circuit breaking, battery protection and smart grid load switching applications.

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Salipante, Stephen J., Sheena M. Scroggins, Heather L. Hampel, Emily H. Turner, and Colin C. Pritchard. "Microsatellite Instability Detection by Next Generation Sequencing." Clinical Chemistry 60, no. 9 (September 1, 2014): 1192–99. http://dx.doi.org/10.1373/clinchem.2014.223677.

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Abstract BACKGROUND Microsatellite instability (MSI) is a useful phenotype in cancer diagnosis and prognosis. Nevertheless, methods to detect MSI status from next generation DNA sequencing (NGS) data are underdeveloped. METHODS We developed an approach to detect the MSI phenotype using NGS (mSINGS). The method was used to evaluate mononucleotide microsatellite loci that were incidentally sequenced after targeted gene enrichment and could be applied to gene or exome capture panels designed for other purposes. For each microsatellite locus, the number of differently sized repeats in experimental samples were quantified and compared to a population of normal controls. Loci were considered unstable if the experimental number of repeats was statistically greater than in the control population. MSI status was determined by the fraction of unstable microsatellite loci. RESULTS We examined data from 324 samples generated using targeted gene capture assays of 3 different sizes, ranging from a 0.85-Mb to a 44-Mb exome design and incorporating from 15 to 2957 microsatellite markers. When we compared mSING results to MSI-PCR as a gold standard for 108 cases, we found the approach to be both diagnostically sensitive (range of 96.4% to 100% across 3 panels) and specific (range of 97.2% to 100%) for determining MSI status. The fraction of unstable microsatellite markers calculated from sequencing data correlated with the number of unstable loci detected by conventional MSI-PCR testing. CONCLUSIONS NGS data can enable highly accurate detection of MSI, even from limited capture designs. This novel approach offers several advantages over existing PCR-based methods.

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Neller, Todd W., and Daniel Ziegler. "Computer Generation of Birds of a Feather Puzzles." Proceedings of the AAAI Conference on Artificial Intelligence 33 (July 17, 2019): 9693–99. http://dx.doi.org/10.1609/aaai.v33i01.33019693.

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In this article, we describe a computer-aided design process for generating high-quality Birds of a Feather solitaire card puzzles. In each iteration, we generate puzzles via combinatorial optimization of an objective function. After solving and subjectively rating such puzzles, we compute objective puzzle features and regress our ratings onto such features to provide insight for objective function improvements. Through this iterative improvement process, we demonstrate the importance of the halfway solvability ratio in quality puzzle design. We relate our observations to recent work on tension in puzzle design, and suggest next steps for more efficient puzzle generation.

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Peitsch, Manuel C., Riccardo Polosa, Christopher Proctor, Thord Hassler, Marianna Gaca, Erin Hill, Julia Hoeng, and A. Wallace Hayes. "Next-generation tobacco and nicotine products." Toxicology Research and Application 2 (January 1, 2018): 239784731877370. http://dx.doi.org/10.1177/2397847318773701.

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A framework for the assessment of novel next-generation tobacco and nicotine products with the potential to reduce health risks compared with cigarettes should integrate scientific studies incorporating nonclinical, clinical, and population studies approaches. These products should have lower emissions and exhibit reduced biological effects compared with those of cigarettes, ideally approaching those of smoking cessation. The products should also be acceptable cigarette alternatives for current smokers, while not appealing to nonsmokers or former smokers. Validating harm reduction and promoting regulatory acceptance of the assessment methods require a collaborative approach by industry, independent reviewers, the public health community, and regulatory agencies. This article summarizes the science and approaches applied and considered to substantiate tobacco harm reduction in the light of regulatory requirements, presented at the 53rd Congress of the European Societies of Toxicology, 2017.

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Feagan, Mathieu Lawrence. "Fostering the next generation of sustainability leadership." International Journal of Sustainability in Higher Education 19, no. 4 (May 8, 2018): 681–98. http://dx.doi.org/10.1108/ijshe-11-2016-0202.

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Purpose This paper aims to explore graduate student experiences of ecohealth communities of practice in Canada, West and Central Africa and Central America, to better understand the role of student knowledge in advancing innovative practices in transdisciplinary, participatory and equitable research approaches. Design/methodology/approach This ethnographic analysis builds on observations of graduate student participants in ecohealth communities of practice activities, along with 26 in-depth interviews conducted in 2011 with graduate students and professionals trained in ecosystem approaches to health. Interviews are transcribed by the author, and coded and analyzed using a grounded theory approach. Findings Although ecohealth communities of practice open new space for students to experiment with innovative practices in transdisciplinary, participatory and equitable research approaches, the surrounding disciplinary, top-down structure of academic and professional careers continue to pose significant obstacles to how students can take up the principles of ecohealth in practice. Through their collective experiences of these obstacles, students have considerable knowledge about the opportunities and constraints that the ecohealth communities of practice afford; however, this student knowledge has not yet been systematized or adequately mobilized. Practical implications Student knowledge gained through shared experiences of ecohealth communities of practice appears to be a critical, necessary and underused component in working on systemic change in the structure of sustainability leadership in higher education. However, more research is needed to understand how greater emphasis could be placed on putting students in charge of confronting the conditions of their own training, to collectively produce alternatives that challenge dominant structural norms. Originality/value The ethnographic approach re-centers student voices within debates about the relevance of ecohealth communities of practice for realizing the aims of transdisciplinary, participatory and equitable research approaches within the context of international sustainability challenges and graduate training.

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YOSHIDA, TADUO. "5. New approach for acquirment and training of next generation." NIPPON SUISAN GAKKAISHI 82, no. 3 (2016): 363. http://dx.doi.org/10.2331/suisan.wa2259-6.

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Żmieńko, Agnieszka, Paulina Jackowiak, and Marek Figlerowicz. "PERSPECTIVES Transcriptome sequencing: next generation approach to RNA functional analysis." BioTechnologia 4 (2011): 311–19. http://dx.doi.org/10.5114/bta.2011.46548.

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Thilakawardana, D., K. Moessner, and R. Tafazolli. "Darwinian approach for dynamic spectrum allocation in next generation systems." IET Communications 2, no. 6 (2008): 827. http://dx.doi.org/10.1049/iet-com:20070502.

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McConnell, Lauren, Oisín Houghton, Peter Stewart, Jana Gazdova, Shambhavi Srivastava, Chang Kim, Mark Catherwood, et al. "A novel next generation sequencing approach to improve sarcoma diagnosis." Modern Pathology 33, no. 7 (February 11, 2020): 1350–59. http://dx.doi.org/10.1038/s41379-020-0488-1.

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Cha, Sung-Woon, and Kyu-Kab Cho. "Development of DVD for the Next Generation by Axiomatic Approach." CIRP Annals 48, no. 1 (1999): 85–88. http://dx.doi.org/10.1016/s0007-8506(07)63137-0.

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Saengkaew, Tansit, and Sasha R. Howard. "Next-generation sequencing approach in the diagnosis of delayed puberty." Current Opinion in Endocrine and Metabolic Research 14 (October 2020): 59–64. http://dx.doi.org/10.1016/j.coemr.2020.05.003.

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Kelleher, Philip, James Murphy, Jennifer Mahony, and Douwe van Sinderen. "Next-generation sequencing as an approach to dairy starter selection." Dairy Science & Technology 95, no. 5 (April 24, 2015): 545–68. http://dx.doi.org/10.1007/s13594-015-0227-4.

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Wong, Lee-Jun, Xia Tian, Yanming Feng, Jing Wang, and Victor Wei Zhang. "Improved diagnosis of mitochondrial disorders by next generation sequencing approach." Mitochondrion 13, no. 6 (November 2013): 932–33. http://dx.doi.org/10.1016/j.mito.2013.07.089.

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