Dissertations / Theses on the topic 'Neuroplasticity'
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Abrahamsson, Sebastian. "Neuroplasticity induced by exercise." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-13909.
Full textWatt, William C. "Neuroplasticity in olfactory sensation /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/6252.
Full textRossi, Sonja. "Neuroplasticity of word learning." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19420.
Full textWord learning accompanies our everyday life from infancy to advanced age. Infants have to learn the native language(s) but also during adulthood word learning can take place, for example if we learn a new foreign language. Sometimes people are confronted with a situation in which they have to re-learn a language because of a brain lesion. How does the brain master these challenging word learning settings? To assess neuroplasticity of word learning several neuroscientific methods (electroencephalography, functional near-infrared spectroscopy, voxel-based lesion-behavior/EEG mapping), partially in combination, were used in infants, children, and adults as well as in patients suffering from a brain lesion compared to matched elderly controls. In 5 experiments neuronal processing of pseudowords corresponding to native and non-native phonotactic rules (i.e., the combination of different phonemes) was investigated under different learning conditions in monolingual participants. Healthy adults but also 6-month-old infants and elderly subjects and patients were able to differentiate these rules. Involved brain areas included a left-hemispheric network of fronto-temporal regions. When processing universal linguistic features, however, more parietal regions were involved. While adults revealed a clear left-dominant network, 6-month-olds still recruited bilateral brain areas. Differential language trainings (semantic or passive listening trainings) over three consecutive days also modulated brain activation in both infants and adults suggesting a high flexibility for learning native and non-native linguistic regularities. In a 6th experiment, bilingual 5-year-old children learned novel adjectives by means of pragmatic cues and revealed more efficient neuronal mechanisms compared to monolingual children. Findings underline the importance of multi-methodological approaches to get clearer insights into the complex machinery of neuroplasticity.
Voss, Oliver Paul. "AMPA receptor potentiators : mechanisms of neuroplasticity." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/25276.
Full textHabekost, Bonne. "Neuroplasticity induced by peripheral nerve stimulation." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/3062.
Full textTeo, J. T. H. "Motor learning and neuroplasticity in humans." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/17592/.
Full textTisch, S. H. D. "Neuroplasticity following pallidal stimulation for dystonia." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1445124/.
Full textYancey, Madison E. "Computational Simulation and Analysis of Neuroplasticity." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1622582138544632.
Full textThompson, Karen Louise Elliott. "Ear manipulations help model neuroplasticity limitations." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4969.
Full textJacques, Angela. "Investigating the neuroplasticity of emotional memories." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/132644/1/Angela_Jacques_Thesis.pdf.
Full textHakim, Marziah. "Neurogenesis and neuroplasticity following olfactory fear conditioning." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/157474/1/Marziah_Hakim_Thesis.pdf.
Full textYeung, Luk Chong. "A mechanistic model of calcium-dependent synaptic plasticity /." View online version; access limited to Brown University users, 2005. http://wwwlib.umi.com/dissertations/fullcit/3174704.
Full textYuan, Wujie. "Adaptive networks and synaptic plasticity in neural systems : interplay between structure and dynamics." HKBU Institutional Repository, 2012. https://repository.hkbu.edu.hk/etd_ra/1398.
Full textGuegan, Thomas 1983. "Common neuroplasticity mechanisms underlying drugs and food reward." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/125444.
Full textLa adicción a las drogas de abuso y determinados trastornos alimentarios comparten varios síntomas comportamentales. Algunos estudios han sugerido que el consumo excesivo de drogas y de comida palatable podrían producir alteraciones neuronales similares en el circuito cerebral de recompensa. En esta tesis, hemos demostrado que un aprendizaje operante prolongado con comida palatable provoca la aparición de alteraciones comportamentales y cambios de plasticidad estructurales en el circuito mesocorticolimbico que son reminiscentes de los observados con las drogas de abuso. Así mismo, hemos identificamos al receptor cannabinoide 1 como un sustrato neurobiológico común a estas alteraciones. Finalmente, hemos caracterizado varias proteínas sinápticas implicadas en la reactivación de la memoria asociada a los efectos placenteros de las drogas y la comida palatable. Nuestras observaciones contribuyen a definir las bases neuronales subyacentes a la necesidad de consumir drogas y comida palatable.
Shetty, Kunal. "Motor learning induced neuroplasticity in minimally invasive surgery." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/56079.
Full textOliver, Chicora. "CHEMOKINE MODULATION OF MDPV-INDUCED BEHAVIOR AND NEUROPLASTICITY." Diss., Temple University Libraries, 2019. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/596047.
Full textPh.D.
Psychostimulant abuse is a major public health concern yet no FDA-approved medications exist. Synthetic cathinones (“bath salts”) are a class of psychostimulants that have emerged relatively recently worldwide. One synthetic cathinone, MDPV (3,4-methylenedioxypyrovalerone) is mechanistically similar to cocaine but is over ten times more potent, possesses high abuse potential, and is relatively understudied. Recent studies have revealed involvement of inflammatory proteins called chemokines in the rewarding effects of MDPV and the mechanistically similar drug, cocaine. We and others have shown that the chemokine-receptor ligand pair CXCL12-CXCR4 is recruited in the rewarding effects of cocaine and MDPV. Humans and animal models of cocaine addiction have dysregulated CXCL12 and the commercially-available CXCR4 antagonist, AMD3100, can reverse cocaine use and relapse in preclinical models of addiction. Specifically, AMD3100 reduces self-administration and reinstatement to cocaine-seeking with concomitant alterations in CXCL12 gene expression in the midbrain. Here, I employ several complementary methods to demonstrate that AMD3100 also reverses MDPV-elicited behaviors. I demonstrate that (i) AMD3100 reverses MDPV-induced hyperlocomotion, conditioned place preference (preclinical model of drug reward), self-administration and reinstatement to MDPV-seeking behavior; (ii) AMD3100 can rescue MDPV-induced deficits in measures of anxiety and recognition memory shortly after a binge; and (iii) repeated MDPV exposure upregulates CXCL12 gene expression in the nucleus accumbens with concomitant downregulation of dendrite morphometrics and a related synapse scaffolding protein gene expression. These findings implicate CXCR4-CXCL12 signaling in the modulation of MDPV-elicited behaviors, suggesting that AMD3100 is a viable therapeutic option for the effects of this synthetic cathinone.
Temple University--Theses
Catuara, Solarz Silvina 1986. "Neuroplasticity-targeted therapy for Down syndrome: a translational approach." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/523544.
Full textEsta Tesis tiene como objetivo examinar el potencial terapéutico de una intervención orientada a mejorar la neuroplasticidad cerebral, propuesta para mitigar la discapacidad intelectual (DI) en el síndrome de Down (SD). La terapia consistió en la administración de la catequina del té verde, Epigalocatequina-3-galato (EGCG), que es un modulador natural de dos genes candidatos que se encuentran en Hsa21, Dyrk1A y APP, en combinación con estimulación cognitiva. La evaluación de la eficacia terapéutica de esta intervención se realizó utilizando un enfoque de la translacional, incluyendo estudios preclínicos con un modelo de ratón de SD y ensayos clínicos con adultos jóvenes con SD. Este trabajo demuestra por primera vez que esta terapia combinada atenúa significativamente los déficits cognitivos en ratones y adultos jóvenes con SD, mediante la modificación de la estructura y función de redes neuronales en el cerebro.
Hamrahi, Hormoz. "Neuroplasticity in the cochlear nucleus of the developing chinchilla." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ34087.pdf.
Full textKlinger, Mary Beth. "Neuroplasticity of Micturition Reflex Pathways with Cyclophosphamide-Induced Cystitis." ScholarWorks @ UVM, 2008. http://library.uvm.edu/dspace/bitstream/123456789/173/1/marybethklingerfinal.pdf.
Full textWong, Scott Thaddeus. "Role of the calcium-stimulated adenylyl cyclases in neuroplasticity /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/6300.
Full text林綺鈴 and Yee-ling Lam. "Proheparanase action at excitatory synapses : implication on synaptic plasticity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193096.
Full textpublished_or_final_version
Biochemistry
Master
Master of Philosophy
Pons, Espinal Meritxell 1986. "Role of DYRK1A in hippocampal neuroplasticity : implications for Down syndrome." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/124485.
Full textLes connexions sinàptiques tenen la capacitat de respondre a l’activitat de neurones ajustant les seves propietats biològiques per incrementar els canvis activitat-depenents. Alteracions en la plasticitat neuronal de l’hipocamp s'han suggerit com a mecanismes subjacents als deterioraments cognitius característics en la síndrome de Down (SD). No obstant, es desconeix quins gens específics estan implicats en aquests fenotips en el context de la trisomia del cromosoma 21. DYRK1A és una serina / treonina quinasa, que quan es troba sobreexpressada recapitula el dèficit d'aprenentatge i de memòria depenent de l'hipocamp característic de la SD. En aquesta tesi, s’han estudiat els efectes de la sobreexpressió de DYRK1A en la plasticitat activitat-dependent de l’hipocamp. Hem descobert que ratolins transgènics amb sobreexpressió de Dyrk1A (TgDyrk1A) presenten alteracions morfològiques en les regions CA1 i CA3 de l'hipocamp, una limitació estructural en les connexions neuronals que és rellevant per entendre la relació entre estructura i funció. A més, hem trobat una reducció en la LTP possiblement deguda als canvis en la connectivitat i ocupació dendrítica. L’excitabilitat de les dendrites i la morfologia neuronal són factors determinants de l'eficàcia sinàptica i per tant poden contribuir als dèficits d'aprenentatge i la memòria de l'hipocamp detectats. Hem demostrat defectes importants en la neurogènesi adulta en el gir dentat incloent una reduïda taxa de proliferació cel·lular, alteracions en el cicle cel·lular i reducció de cèl·lules que surten del cicle cel·lular que condueix a una migració precoç de les noves cèl·lules generades i una reducció de la supervivència. D'altra banda, en ratolins TgDyrk1A hi ha menys proporció de neurones generades de novo que s'activen amb l'aprenentatge, indicant una menor integració d’aquestes en els circuits implicats en l'aprenentatge. Algunes d'aquestes alteracions han estat rescatades per la normalització de DYRK1A quinasa utilitzant un inhibidor de DYRK1A, epigallocatechin-3-gallate. L'estimulació del medi ambient també normalitza la sobreexpressió de DYRK1A quinasa en l'hipocamp, i rescata la morfologia, la plasticitat sinàptica i les alteracions en la neurogènesi adulta en ratolins TgDyrk1A. Arribem a la conclusió que Dyrk1A és un bon gen candidat per explicar els dèficits de plasticitat neuronal en la SD i que tractant l’excés d'activitat de la quinasa DYRK1A farmacològicament o mitjançant l'estimulació ambiental en l'adult podria corregir aquests defectes en la SD.
Adams, Louise. "Promotion of neuroplasticity by modifying perineuronal nets using polysialic acid." Thesis, Queen Mary, University of London, 2017. http://qmro.qmul.ac.uk/xmlui/handle/123456789/24547.
Full textAlia, Claudia. "Studying and modulating post-stroke neuroplasticity to improve motor recovery." Doctoral thesis, Scuola Normale Superiore, 2016. http://hdl.handle.net/11384/86002.
Full textMa, Chun-wai. "Study of perineuronal nets in plasticity of central circuitry." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43914524.
Full textXu, Bin. "Axonal growth, neuronal damage and epileptogenesis /." *McMaster only, 2002.
Find full textMa, Chun-wai, and 馬俊偉. "Study of perineuronal nets in plasticity of central circuitry." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43914524.
Full textSánchez-Duran, José Antonio. "Neural plasticity in premotor pathways of the Aplysia feeding system : short-term synaptic modulation of motor programs, synaptic interactions, regeneration of cerebral-buccal connections, and recovery of buccal motor programs /." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3013019.
Full textWainwright, Steven R. "Androgens and neuroplasticity : contributions to the pathogenesis and treatment of depression." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/55848.
Full textMedicine, Faculty of
Graduate
Rossi, Sonja [Verfasser], Heather [Gutachter] Bortfeld, and Erich [Gutachter] Schröger. "Neuroplasticity of word learning / Sonja Rossi ; Gutachter: Heather Bortfeld, Erich Schröger." Berlin : Humboldt-Universität zu Berlin, 2018. http://d-nb.info/1185579176/34.
Full textWansbrough, Kym. "The efficacy of non-invasive brain stimulation protocols for inducing neuroplasticity." Thesis, Wansbrough, Kym (2016) The efficacy of non-invasive brain stimulation protocols for inducing neuroplasticity. Honours thesis, Murdoch University, 2016. https://researchrepository.murdoch.edu.au/id/eprint/40685/.
Full textFacchini, Silvia. "Neuroplasticity in Neuro-oncology: Neuropsychological and neuroimaging correlates of brain tumors." Doctoral thesis, Università degli studi di Padova, 2020. http://hdl.handle.net/11577/3426167.
Full textJonckheere, Ruiz de Larrinaga Julie. "Bases moléculaires et cellulaires des effets antidépresseurs de l'électro-convulsivothérapie (ECT)." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAV023/document.
Full textIn Major depressive disorder, the electroconvulsive therapy (ECT) is recognized as an effective treatment to face drug-resistance and action latency of pharmacological agents. Although the therapeutic efficacy of ECT is internationally recognized, the ill-characterized biological effects of ECT contribute to discredit this treatment. Direct access of specific markers in human is not easy, prompting the development of the animal counterpart of ECT, the electro convulsive stimulations (ECS). To date, current results arising from ECS studies in animals remain not fully conclusive because mainly data have been obtained with unchallenged/naive animals. The objective of this project was to analyze the biological and behavioral effects of ECS treatment, on an animal model of psychiatric disorder: the MAP6-KO mice. Indeed MAP6-KO mice (also known as STOP KO mice) constitutively exhibit behavioural and biological features relevant to some aspects of major depressive disorder. We found that ECS treatment has an overall beneficial effect on several constitutive behavioural defects, displayed by MAP6 KO mice, with variable lasting times. At biological levels, ECS treatment did not induce detectable modification of brain proteins expression pattern, but induce an overall increase of hippocampal neurogenesis, and more particularly potentiate the survival rate of newborn neurons, probably through an increase dendritic complexity and dendritic spines density. We also found that ECS enhance dendritic spines density in vivo in cortical neurons and increase hippocampal levels of the trophic factor, BDNF. In summary our work provide evidence that ECS treatment when applied to MAP6 KO mice induces major neuronal plasticity events, the stronger being the increased integration rate of hippocampal new-born neurons
Ofori, Ernest Kwesi. "EFFECT OF OPTOGENETIC STIMULATION ON NEUROPLASTICITY OF THE EMBRYONIC CHICK MOTOR SYSTEM." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1458.
Full textCalvert, Dorys Faria. "L'expérience théâtrale comme expérience de transformation : théâtre et neuroscience des émotions." Thesis, Paris 3, 2014. http://www.theses.fr/2014PA030122.
Full textThis is an interdisciplinary study – essentially encompassing theater, psychology and neuroscience – whose goal is to analyze the transforming (and, somehow, therapeutic) potential inherent to theater practice. This work is divided into two core areas of investigation: the first focuses on the dialogue that the theater has had with the life sciences throughout the history of Western civilization, highlighting the idea that the scientific study of emotions is presented as the main thread between theoretical and practical exchanges of the performing arts and life sciences. The second focus area of this research concerns the relationship between contemporary neuroscience of emotions, the work of the actor and the transformations that could occur through the theatrical experience – especially for the actor – on an ontological level. In this research, some neuroscientific concepts that prove fundamental to the development of a neurobiological approach to the emotional work of the actor have been developed. They are: neuroplasticity, the neuron mirror system, the brain gratification circuit and the conscious use of the procedural memory
Cefis, Marina. "Impact des modalités d'un exercice physique sur la neuroplasticité. Focus sur les sources de BDNF." Thesis, Bourgogne Franche-Comté, 2019. http://www.theses.fr/2019UBFCK049/document.
Full textPhysical exercise (EX) is recognized as the most potent non-pharmacological strategy to positively enhance brain health. From Human and animal studies there is a consensus to involve brain-derived neurotrophic factor (BDNF), a neurotrophin strongly expressed in response to EX and implicated in neuroplasticity mechanisms. Mainly expressed by neurons, BDNF is also expressed by endothelial and muscle cells. Largely sought during a physical effort, endothelium and skeletal muscle could be involved in positive effects induced by EX. Although there is a real consensus about BDNF and cerebral effect of EX, the typology of the better regimen of EX to enhance cerebral plasticity is not known. In this context, objectives of this works were to determine the impact of EX modalities on BDNF protein expression in different territory (brain, endothelium and muscle) and to identify mechanisms related in BDNF increases in response to EX.Our results showed that 1) BDNF expression in peripheral vessels from the same vascular territory (distinct internal diameter) is similar in response to EX, 2) cerebral BDNF increases induced by EX is dependent on EX intensity but not on the type of contraction (eccentric/concentric), 3) memory is restored by high intensity EX, 4) after EX, BDNF muscular expression is unchanged while the precursor of irisine (FNDC5) expression is increased, 5) BDNF expression depends on muscular fibers typology, 6) cerebral beneficial effects of EX intensity is might not be related to muscular irisine production.In conclusion, our data demonstrated that EX positively impact endothelial, cerebral but not muscular BDNF expression. Results highlighted the importance of the intensity parameter of EX on cerebral BDNF levels. Finally, according to our data, irisine and BDNF from the muscle might not be related to the cerebral increases of BDNF induced by EX intensity
Matamala, Gómez Marta. "The use of immersive virtual reality in neurorehabilitation and its impact in neuroplasticity." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/666826.
Full textLa presente tesis pretende hacer una breve revisión de las diferentes técnicas de integración multisensorial en rehabilitación utilizando principalmente el feedback visual y que han llevado a la implementación de la realidad virtual como herramienta terapéutica. Actualmente, la realidad virtual está adquiriendo un papel importante en el campo de la rehabilitación, y en específico en el campo de la neurorehabilitación para el tratamiento de alteraciones motoras, cognitivas y síndromes dolorosos. Sin embargo, todavía es una incógnita cuál es la manera más efectiva de aplicarla y que pacientes se pueden beneficiar en mayor grado de ella. Por esta razón, en esta tesis doctoral se presentan tres diferentes estudios en los cuales se aplica el uso de un sistema de realidad virtual immersiva, generando la ilusión de posesión de un cuerpo virtual. Específicamente, el primer estudio está realizado con pacientes ortopédicos. El segundo estudio es un caso estudio realizado con tres pacientes neurológicos, y el tercer estudio está realizado con un grupo de pacientes que sufren dolor crónico neuropático. En los tres estudios, se demuestra que el hecho de generar la ilusión de posesión de un cuerpo virtual mediante el uso de un sistema de realidad virtual immersiva, permite mejorar déficits motores, cognitivos y dolorosos en diferentes patologías. Esta tesis doctoral abre el camino a la introducción de nuevas técnicas de tratamiento en el campo de la neurorehablitación mediante el uso de técnicas de integración multisensorial, como los sistemas de realidad virtual immersiva.
Ireland, Shelley Margaret Lorraine. "The plasticity of the visual system following damage of the brachium of the superior colliculus in neonatal and adult hamsters :." Thesis, [Hong Kong : University of Hong Kong], 1991. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13204907.
Full textSiu, Timothy Lok Tin Medical Sciences Faculty of Medicine UNSW. "Artificial vision: feasibility of an episcleral retinal prosthesis & implications of neuroplasticity." Awarded By:University of New South Wales. Medical Sciences, 2009. http://handle.unsw.edu.au/1959.4/42879.
Full textWilson, Edward. "Investigating signal cascades promoting activity-dependent neuroplasticity in monkey primary visual cortex." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106492.
Full textLe système visuel du primate constitue un modèle idéal pour l'étude du développement neuronal et de la neuroplasticité dépendante de l'activité. L'organisation finale du cortex visuel est basée sur une organisation cellulaire génétiquement déterminée, programmée pour être influencée par l'environnement de l'animal pendant une période critique du développement post-natal.Ainsi, les connections neuronales sont formées par l'expérience sensorielle de l'animal. La plasticité du système visuel décline après la fin de cette période critique et, bien qu'existante chez les animaux matures, elle est grandement diminuée. Par contre, la plasticité corticale peut être rétablie après la fin de la période critique en altérant l'activité neuronale entrante à laquelle le système s'est adapté. Par exemple, empêcher que l'information reliée à la lumière se rende au système visuel provoque la réorganisation corticale chez les primates en bas âge et adultes, de façon à ce que les neurones privées deviennent réceptives aux entrées provenant de l'œil ouvert.Le facteur de transcription CREB (cAMP Response Element-Binding) contribue aux fonctions cellulaires requises pour le remodelage des circuits corticaux. En fait, en répondant aux variations de l'activité neuronale, CREB utilise des mécanismes autodirigés pour créer des circuits fonctionnels. Pour cette raison, il n'est pas surprenant que CREB soit impliqué dans la plasticité reliée à la dominance oculaire (DO) qui se produit dans le cortex visuel primaire à la suite de l'inactivation monoculaire (IM). Précisément, les niveaux de la forme activée de CREB (phosphorylée au site serine-133) sont élevés en réponse aux changements d'activité neuronale à la fois dans les zones visuelles privées et non privées des entrées provenant de l'oeil. Le problème relié à cette observation est le fait qu'elle n'explique pas pourquoi CREB peut induire un changement de la dominance oculaire chez les neurones privées alors que celles non privées ne sont pas remodelées.Les nouveaux résultats expérimentaux présentés ici démontrent des changements au niveau de la quantité de CREB inhibé suite à l'IM qui sont spécifiques aux zones. De plus, il a été démontré que le signal du cofacteur transcriptionnel critique de CREB, TORC1, est rétabli à un niveau comparable à celui de la période critique chez les adultes après l'IM. Le CREB inhibé était augmenté dans les zones privées, alors que TORC1 était augmenté dans les zones non privées. Ensembles, ces résultats suggèrent que a) la modulation différentielle des résidus de CREB et l'activation de ses cofacteurs pourraient contribuer à son habileté à produire des effets dépendants du contexte et b) la plasticité reliée à la DO nécessite le déséquilibre de l'activation de CREB de façon à ce que CREB est potentialisé dans les zones non-privées comparées aux zones privées.
Reay, Riaan. "The effects of sildenafil on neuroplasticity in human neuroblastoma cells / Riaan Reay." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4903.
Full textThesis (M.Sc. (Pharmacology))--North-West University, Potchefstroom Campus, 2010.
Sturdy, Elliot. "The Administration of the Flesh : The discourse of self-improvement and neuroplasticity." Thesis, Stockholms universitet, Institutionen för etnologi, religionshistoria och genusvetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-145383.
Full textANDRENELLI, ELISA. "Advanced technologies enhance exercise effectiveness in neurodegenerative disorders: evidence from neuroplasticity studies." Doctoral thesis, Università Politecnica delle Marche, 2019. http://hdl.handle.net/11566/263447.
Full textNeurodegenerative diseases such as Parkinson’s disease and multiple sclerosis are characterised by the appearance of reactive microglial and astroglial cells, a process referred to as neuroinflammation. Activation of glia cells can induce an increase in the levels of pro- and antiinflammatory cytokines and reactive oxygen species, which can lead to the modulation of neuronal function and neurotoxicity observed in several brain pathologies. There is no conclusive evidence that can classify the inflammation as a cause or a consequence of the disease onset. However, therapeutic approaches specifically targeting neuroinflammation and neuroplasticity may represent an effective strategy to interfere with the disease progression and consequently for preventing or treating the related symptoms. Exercise is known to effectively modulate inflammation and has been reported to change the inflammatory state to become anti-inflammatory or neuroprotective. Moreover, exercise increases synaptic plasticity by directly affecting synaptic structure and potentiating synaptic strength, and indirectly by strengthening the underlying systems that support plasticity including neurogenesis, metabolism and vascular function. More studies are needed to elucidate the likely range of intensity, duration, frequency, and type (aerobic or task oriented) of exercise that is required to induce such important target responses. In the following studies we showed how specific gait training could improve symptoms that are unresponsive or that poorly respond to pharmacological treatment in two common neurodegenerative disorders, Parkinson's disease and multiple sclerosis. At baseline assessment, all patients enrolled, either suffering from Parkinson's disease or multiple sclerosis, showed an impaired neuroplasticity that recovered only after robot gait training. This neurophysiological result was correlated to clinical improvement of the freezing of gait in Parkinson's disease and gait and balance in multiple sclerosis.
Traini, Enea. "Cholinergic enhancing strategies and brain neuroplasticity. From preclinical evidence to clinical applications." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/4076.
Full textBaum, David. "Dimorphismes sexuels de la neuroplasticité respiratoire associée au syndrome d'apnées obstructives du sommeil et caractérisation d'un nouveau modèle murin." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS044/document.
Full textThe obstructive sleep apnea syndrome (OSAS) is characterized by recurrent collapse of the upper airways during sleep, generating episodes of hypoxia/hypercapnia. Thus, OSAS leads to life-threatening cardiorespiratory comorbidities, but of which some are less severe in female patients. The prevalence in men is higher than that of pre-menopausal women and it is increased by obesity. This doctoral thesis aimed to characterize sex differences in the neuroplasticity related to cardi-orespiratory comorbidities found in OSAS. In this context, we submitted mice to a protocol of chronic intermittent hypoxia, a model that recapitulates episodic hypoxia of OSAS. On isolated brain sections, we observed differential implication of cardiorespiratory structures between male and female mice with a specific neuroplastic pattern in females that could possibly explain sex differences observed in OSAS patients. In parallel, we have characterized an obese mouse strain (New Zealand Obese) as a model of OSAS. Thus, we provide the first naturel mouse model for OSAS related to obesity. The work presented in this thesis provides better understanding of sex differences observed in OSAS and provides a new model of OSAS that should allow more complete studies of the pathology of OSAS
Bosnyak, Daniel J. Roberts L. E. "Mechanisms and dynamics of the human auditory steady-state response /." *McMaster only, 2003.
Find full textYuen, Sung-lai. "Plasticity of human brain networks as revealed by functional magnetic resonance imaging." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38837602.
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Full textHarrison, Elaine. "Morphological correlates of synaptic plasticity after long term potentiation in the rat hippocampus." n.p, 2000. http://library7.open.ac.uk/abstracts/page.php?thesisid=44.
Full textRakai, Brooke D., and University of Lethbridge Faculty of Arts and Science. "Experience dependent plasticity of stroke outcome." Thesis, Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2008, 2008. http://hdl.handle.net/10133/2518.
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