Relevant bibliographies by topics / Neuropeptide Y

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Academic literature on the topic 'Neuropeptide Y'

Author: Grafiati
Published: 4 June 2021
Last updated: 28 July 2024

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Journal articles on the topic "Neuropeptide Y"

1

Veenstra, Jan A. "Coleoptera genome and transcriptome sequences reveal numerous differences in neuropeptide signaling between species." PeerJ 7 (June 17, 2019): e7144. http://dx.doi.org/10.7717/peerj.7144.

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Background Insect neuropeptides are interesting for the potential their receptors hold as plausible targets for a novel generation of pesticides. Neuropeptide genes have been identified in a number of different species belonging to a variety of insects. Results suggest significant neuropeptide variation between different orders, but much less is known of neuropeptidome variability within an insect order. I therefore compared the neuropeptidomes of a number of Coleoptera. Methodology Publicly available genome sequences, transcriptomes and the original sequence data in the form of short sequence read archives were analyzed for the presence or absence of genes coding neuropeptides as well as some neuropeptide receptors in seventeen beetle species. Results Significant differences exist between the Coleoptera analyzed here, while many neuropeptides that were previously characterized from Tribolium castaneum appear very similar in all species, some are not and others are lacking in one or more species. On the other hand, leucokinin, which was presumed to be universally absent from Coleoptera, is still present in non-Polyphaga beetles. Conclusion The variability in neuropeptidome composition between species from the same insect order may be as large as the one that exists between species from different orders.
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Southey, Bruce R., and Sandra L. Rodriguez-Zas. "Changes in Neuropeptide Prohormone Genes among Cetartiodactyla Livestock and Wild Species Associated with Evolution and Domestication." Veterinary Sciences 9, no. 5 (May 23, 2022): 247. http://dx.doi.org/10.3390/vetsci9050247.

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The impact of evolution and domestication processes on the sequences of neuropeptide prohormone genes that participate in cell–cell signaling influences multiple biological process that involve neuropeptide signaling. This information is important to understand the physiological differences between Cetartiodactyla domesticated species such as cow, pig, and llama and wild species such as hippopotamus, giraffes, and whales. Systematic analysis of changes associated with evolutionary and domestication forces in neuropeptide prohormone protein sequences that are processed into neuropeptides was undertaken. The genomes from 118 Cetartiodactyla genomes representing 22 families were mined for 98 neuropeptide prohormone genes. Compared to other Cetartiodactyla suborders, Ruminantia preserved PYY2 and lost RLN1. Changes in GNRH2, IAPP, INSL6, POMC, PRLH, and TAC4 protein sequences could result in the loss of some bioactive neuropeptides in some families. An evolutionary model suggested that most neuropeptide prohormone genes disfavor sequence changes that incorporate large and hydrophobic amino acids. A compelling finding was that differences between domestic and wild species are associated with the molecular system underlying ‘fight or flight’ responses. Overall, the results demonstrate the importance of simultaneously comparing the neuropeptide prohormone gene complement from close and distant-related species. These findings broaden the foundation for empirical studies about the function of the neuropeptidome associated with health, behavior, and food production.
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Pidsudko, Z., J. Kaleczyc, J. Zmudzki, W. Sienkiewicz, M. Zalecki, M. Klimczuk, and K. Wasowicz. "Changes in the tissue concentrations of several neuropeptides in porcine intestines and intestine-innervating ganglia in the course of porcine proliferative enteropathy." Veterinární Medicína 63, No. 5 (May 29, 2018): 210–15. http://dx.doi.org/10.17221/62/2017-vetmed.

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Inflammatory processes are associated with changes in the interplay of different pro- and anti-inflammatory factors, including neuropeptides, in tissue. This study was performed to investigate the influence of proliferative enteropathy on the concentration of several neuropeptides known to be involved in the regulation of the inflammatory process in porcine intestine and intestine-innervating ganglia. The concentration of galanin, vasoactive intestinal polypeptide, somatostatin, neuropeptide Y, substance P and calcitonin gene-related peptide were assayed with ELISA in the coeliac-superior mesenteric ganglion, inferior mesenteric ganglion, selected dorsal root ganglia, ileum and the descending colon in healthy and sick pigs. The concentrations of the studied neuropeptides were higher in sick animals. Statistically significant differences were found for coeliac-superior mesenteric ganglion (galanin, vasoactive intestinal polypeptide, somatostatin and neuropeptide Y), inferior mesenteric ganglion (galanin, somatostatin and neuropeptide Y), dorsal root ganglia (galanin, somatostatin, neuropeptide Y and calcitonin gene-related peptide), ileum (galanin and somatostatin) and the descending colon (galanin, somatostatin and neuropeptide Y). The data clearly show the influence of the inflammatory process on the concentration of some of the studied neuropeptides present in inflamed tissues and ganglia innervating the inflamed gut. These changes must be associated with the role the studied neuropeptides play in the inflammatory process.
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Avgan, Nesli, Heidi G. Sutherland, Rod A. Lea, Larisa M. Haupt, David H. K. Shum, and Lyn R. Griffiths. "Association Study of a Comprehensive Panel of Neuropeptide-Related Polymorphisms Suggest Potential Roles in Verbal Learning and Memory." Genes 15, no. 1 (December 24, 2023): 30. http://dx.doi.org/10.3390/genes15010030.

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Neuropeptides are mostly expressed in regions of the brain responsible for learning and memory and are centrally involved in cognitive pathways. The majority of neuropeptide research has been performed in animal models; with acknowledged differences between species, more research into the role of neuropeptides in humans is necessary to understand their contribution to higher cognitive function. In this study, we investigated the influence of genetic polymorphisms in neuropeptide genes on verbal learning and memory. Variants in genes encoding neuropeptides and neuropeptide receptors were tested for association with learning and memory measures using the Hopkins Verbal Learning Test—Revised (HVLT-R) in a healthy cohort of individuals (n = 597). The HVLT-R is a widely used task for verbal learning and memory assessment and provides five sub-scores: recall, delay, learning, retention, and discrimination. To determine the effect of candidate variants on learning and memory performance, genetic association analyses were performed for each HVLT-R sub-score with over 1300 genetic variants from 124 neuropeptide and neuropeptide receptor genes, genotyped on Illumina OmniExpress BeadChip arrays. This targeted analysis revealed numerous suggestive associations between HVLT-R test scores and neuropeptide and neuropeptide receptor gene variants; candidates include the SCG5, IGFR1, GALR1, OXTR, CCK, and VIPR1 genes. Further characterization of these genes and their variants will improve our understanding of the genetic contribution to learning and memory and provide insight into the importance of the neuropeptide network in humans.
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Zandawala, Meet, Ismail Moghul, Luis Alfonso Yañez Guerra, Jérôme Delroisse, Nikara Abylkassimova, Andrew F. Hugall, Timothy D. O'Hara, and Maurice R. Elphick. "Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms." Open Biology 7, no. 9 (September 2017): 170129. http://dx.doi.org/10.1098/rsob.170129.

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Neuropeptides are a diverse class of intercellular signalling molecules that mediate neuronal regulation of many physiological and behavioural processes. Recent advances in genome/transcriptome sequencing are enabling identification of neuropeptide precursor proteins in species from a growing variety of animal taxa, providing new insights into the evolution of neuropeptide signalling. Here, detailed analysis of transcriptome sequence data from three brittle star species, Ophionotus victoriae , Amphiura filiformis and Ophiopsila aranea , has enabled the first comprehensive identification of neuropeptide precursors in the class Ophiuroidea of the phylum Echinodermata. Representatives of over 30 bilaterian neuropeptide precursor families were identified, some of which occur as paralogues. Furthermore, homologues of endothelin/CCHamide, eclosion hormone, neuropeptide-F/Y and nucleobinin/nesfatin were discovered here in a deuterostome/echinoderm for the first time. The majority of ophiuroid neuropeptide precursors contain a single copy of a neuropeptide, but several precursors comprise multiple copies of identical or non-identical, but structurally related, neuropeptides. Here, we performed an unprecedented investigation of the evolution of neuropeptide copy number over a period of approximately 270 Myr by analysing sequence data from over 50 ophiuroid species, with reference to a robust phylogeny. Our analysis indicates that the composition of neuropeptide ‘cocktails’ is functionally important, but with plasticity over long evolutionary time scales.
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Semmens, Dean C., Isabel Beets, Matthew L. Rowe, Liisa M. Blowes, Paola Oliveri, and Maurice R. Elphick. "Discovery of sea urchin NGFFFamide receptor unites a bilaterian neuropeptide family." Open Biology 5, no. 4 (April 2015): 150030. http://dx.doi.org/10.1098/rsob.150030.

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Neuropeptides are ancient regulators of physiology and behaviour, but reconstruction of neuropeptide evolution is often difficult owing to lack of sequence conservation. Here, we report that the receptor for the neuropeptide NGFFFamide in the sea urchin Strongylocentrotus purpuratus (phylum Echinodermata) is an orthologue of vertebrate neuropeptide-S (NPS) receptors and crustacean cardioactive peptide (CCAP) receptors. Importantly, this has facilitated reconstruction of the evolution of two bilaterian neuropeptide signalling systems. Genes encoding the precursor of a vasopressin/oxytocin-type neuropeptide and its receptor duplicated in a common ancestor of the Bilateria. One copy of the precursor retained ancestral features, as seen in highly conserved vasopressin/oxytocin–neurophysin-type precursors. The other copy diverged, but this took different courses in protostomes and deuterostomes. In protostomes, the occurrence of a disulfide bridge in neuropeptide product(s) of the precursor was retained, as in CCAP, but with loss of the neurophysin domain. In deuterostomes, we see the opposite scenario—the neuropeptides lost the disulfide bridge, and neurophysin was retained (as in the NGFFFamide precursor) but was subsequently lost in vertebrate NPS precursors. Thus, the sea urchin NGFFFamide precursor and receptor are ‘missing links’ in the evolutionary history of neuropeptides that control ecdysis in arthropods (CCAP) and regulate anxiety in humans (NPS).
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Ryznar, Rebecca, Nathan Andrews, Kyle Emery, Michaela Snow, Mark Payton, Francina Towne, and Dean Gubler. "Specific Salivary Neuropeptides Shift Synchronously during Acute Stress in Fire Recruits." Brain Sciences 14, no. 5 (May 13, 2024): 492. http://dx.doi.org/10.3390/brainsci14050492.

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Once thought of as an immune-privileged site, we now know that the nervous system communicates in a bidirectional manner with the immune system via the neuroimmune axis. Neuropeptides constitute a component of this axis, playing critical roles in the brain and periphery. The function of salivary neuropeptides in the acute stress response is not well understood. The purpose of this study is to investigate salivary neuropeptide levels during acute stress. Salivary samples were collected from fire recruits engaged in a stress training exercise previously shown to induce acute stress, at three separate timepoints during the exercise and levels of oxytocin, neurotensin, Substance P, α-MSH, and β-Endorphin were measured using the Human Neuropeptide 5-Plex Custom Assay Eve Technologies. All neuropeptides increased throughout the acute stress simulation and during the recovery phase. Exploratory factor analysis (EFA) identified one factor contributing to baseline values across five neuropeptides and Pairwise Pearson Correlation Coefficient analysis showed positive correlations >0.9 for almost all neuropeptide combinations at the pre-stress timepoint. Further analysis identified negative and positive correlations between past-life trauma and self-assessed hardiness, respectively. Calculated neuropeptide scores showed an overall positive correlation to self-assessed hardiness. Altogether, our results suggest that salivary neuropeptides increase synchronously during acute stress and higher levels correlate with an increase in self-assessed hardiness. Further study is required to determine if interventions designed to enhance neuropeptide activity can increase stress resilience, especially in high-stress occupations such as firefighting.
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Wang, Zhengbing, Wenwu Zhou, Muhammad Hameed, Jiali Liu, and Xinnian Zeng. "Characterization and Expression Profiling of Neuropeptides and G-Protein-Coupled Receptors (GPCRs) for Neuropeptides in the Asian Citrus Psyllid, Diaphorina citri (Hemiptera: Psyllidae)." International Journal of Molecular Sciences 19, no. 12 (December 6, 2018): 3912. http://dx.doi.org/10.3390/ijms19123912.

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Neuropeptides are endogenous active substances that widely exist in multicellular biological nerve tissue and participate in the function of the nervous system, and most of them act on neuropeptide receptors. In insects, neuropeptides and their receptors play important roles in controlling a multitude of physiological processes. In this project, we sequenced the transcriptome from twelve tissues of the Asian citrus psyllid, Diaphorina citri Kuwayama. A total of 40 candidate neuropeptide genes and 42 neuropeptide receptor genes were identified. Among the neuropeptide receptor genes, 35 of them belong to the A-family (or rhodopsin-like), four of them belong to the B-family (or secretin-like), and three of them are leucine-rich repeat-containing G-protein-coupled receptors. The expression profile of the 82 genes across developmental stages was determined by qRT-PCR. Our study provides the first investigation on the genes of neuropeptides and their receptors in D. citri, which may play key roles in regulating the physiology and behaviors of D. citri.
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Veenstra, Jan A. "Similarities between decapod and insect neuropeptidomes." PeerJ 4 (May 26, 2016): e2043. http://dx.doi.org/10.7717/peerj.2043.

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Background.Neuropeptides are important regulators of physiological processes and behavior. Although they tend to be generally well conserved, recent results using trancriptome sequencing on decapod crustaceans give the impression of significant differences between species, raising the question whether such differences are real or artefacts.Methods.The BLAST+ program was used to find short reads coding neuropeptides and neurohormons in publicly available short read archives. Such reads were then used to find similar reads in the same archives, and the DNA assembly program Trinity was employed to construct contigs encoding the neuropeptide precursors as completely as possible.Results.The seven decapod species analyzed in this fashion, the crabsEriocheir sinensis, Carcinus maenasandScylla paramamosain, the shrimpLitopenaeus vannamei, the lobsterHomarus americanus, the fresh water prawnMacrobrachium rosenbergiiand the crayfishProcambarus clarkiihad remarkably similar neuropeptidomes. Although some neuropeptide precursors could not be assembled, in many cases individual reads pertaining to the missing precursors show unambiguously that these neuropeptides are present in these species. In other cases, the tissues that express those neuropeptides were not used in the construction of the cDNA libraries. One novel neuropeptide was identified: elongated PDH (pigment dispersing hormone), a variation on PDH that has a two-amino-acid insertion in its core sequence. Hyrg is another peptide that is ubiquitously present in decapods and is likely a novel neuropeptide precursor.Discussion.Many insect species have lost one or more neuropeptide genes, but apart from elongated PDH and hyrg all other decapod neuropeptides are present in at least some insect species, and allatotropin is the only insect neuropeptide missing from decapods. This strong similarity between insect and decapod neuropeptidomes makes it possible to predict the receptors for decapod neuropeptides that have been deorphanized in insects. This includes the androgenic insulin-like peptide that seems to be homologous to drosophila insulin-like peptide 8.
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Shiraishi, Akira, Toshimi Okuda, Natsuko Miyasaka, Tomohiro Osugi, Yasushi Okuno, Jun Inoue, and Honoo Satake. "Repertoires of G protein-coupled receptors for Ciona-specific neuropeptides." Proceedings of the National Academy of Sciences 116, no. 16 (April 1, 2019): 7847–56. http://dx.doi.org/10.1073/pnas.1816640116.

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Neuropeptides play pivotal roles in various biological events in the nervous, neuroendocrine, and endocrine systems, and are correlated with both physiological functions and unique behavioral traits of animals. Elucidation of functional interaction between neuropeptides and receptors is a crucial step for the verification of their biological roles and evolutionary processes. However, most receptors for novel peptides remain to be identified. Here, we show the identification of multiple G protein-coupled receptors (GPCRs) for species-specific neuropeptides of the vertebrate sister group, Ciona intestinalis Type A, by combining machine learning and experimental validation. We developed an original peptide descriptor-incorporated support vector machine and used it to predict 22 neuropeptide–GPCR pairs. Of note, signaling assays of the predicted pairs identified 1 homologous and 11 Ciona-specific neuropeptide–GPCR pairs for a 41% hit rate: the respective GPCRs for Ci-GALP, Ci-NTLP-2, Ci-LF-1, Ci-LF-2, Ci-LF-5, Ci-LF-6, Ci-LF-7, Ci-LF-8, Ci-YFV-1, and Ci-YFV-3. Interestingly, molecular phylogenetic tree analysis revealed that these receptors, excluding the Ci-GALP receptor, were evolutionarily unrelated to any other known peptide GPCRs, confirming that these GPCRs constitute unprecedented neuropeptide receptor clusters. Altogether, these results verified the neuropeptide–GPCR pairs in the protochordate and evolutionary lineages of neuropeptide GPCRs, and pave the way for investigating the endogenous roles of novel neuropeptides in the closest relatives of vertebrates and the evolutionary processes of neuropeptidergic systems throughout chordates. In addition, the present study also indicates the versatility of the machine-learning–assisted strategy for the identification of novel peptide–receptor pairs in various organisms.
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Dissertations / Theses on the topic "Neuropeptide Y"

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Diez, Margarita. "Neuropeptide expression in mouse disease models /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-514-x/.

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Sjödin, Paula. "Pharmacological studies of four neuropeptide Y-family receptor subtypes /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5925.

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Pheng, Leng-Hong. "Caractérisation pharmacologique des récepteurs natifs du neuropeptide Y et de la nociceptine." Sherbrooke : Université de Sherbrooke, 2001.

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Brumovsky, Pablo R. "Neuropeptides, sensory neurons and pain modulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-442-2/.

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Miskelly, I. R. "Comparative analysis of parasitic nematode neuropeptide and neuropeptide receptor encoding genes." Thesis, Queen's University Belfast, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432533.

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Guery, Sébastien. "Conception et synthèse de dérivés de l'arginine : Concepts et validation sur des récepteurs de neuropeptides." Université Louis Pasteur (Strasbourg) (1971-2008), 2003. https://publication-theses.unistra.fr/public/theses_doctorat/2003/GUERY_Sebastien_2003.pdf.

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La découverte de neuropeptides comme molécules pharmacologiquement actives est d'une importance considérable pour notre compréhension de la neurobiologie. Les neuropeptides peuvent agir en tant que neurotransmetteurs, neuromodulateurs et en tant qu'hormones. Ils contrôlent ou influencent de nombreux types de comportements biologiques (par exemple le comportement sexuel, le comportement alimentaire, la mémoire, l'apprentissage, la perception de la douleur, ). Certains de ces peptides appartiennent à la famille des peptides de type RF-amide qui possèdent dans leur partie C-terminale un résidu Arginine. Dans le cadre de cette thèse, nous nous sommes intéressés à deux peptides : le NPY (neuropeptide Y) et le NPFF (neuropeptide FF) qui possèdent dans leur extrémité C-terminale ce motif RF-amide. Dans un premier temps, notre travail s'est basé sur l'étude des relations structure-activité d'un ligand qui se fixe sur les récepteurs Y1 du NPY et sur les récepteurs du NPFF : le BIBP 3226. Pour ce faire, nous avons dû mettre au point une méthode de synthèse hautement convergente en solution et sur phase solide nous permettant d'obtenir avec de très bons rendements et une excellente pureté des analogues et des dérivés d'arginine. Les études de liaison spécifiques ont permis d'identifier deux composés tête de série : LPI 211 (Ki = 0,10 æM sur NPFF1 et Ki = 0,16 æM sur NPFF2) et LPI 214 (comme antagoniste des récepteurs Y1 du NPY). D'autre part, nous avons également mis au point une méthode de synthèse de composés fluorescents dérivés de l'arginine. Ces composés ont été évalués pour leur capacité à produire du FRET (5 %) sur les récepteurs Y1 du NPY et ce en vue de mettre au point une nouvelle méthode de criblage à haut débit n'utilisant pas de composés radioactifs. Enfin, nous nous sommes également intéressés à la synthèse de composés hétérocycliques peptidomimétiques de type dihydrotriazinones par l'utilisation de la réaction de Ugi. Cette voie de synthèse nous permet d'obtenir des dérivés substitués sur l'azote N1 ou sur l'azote N4 en un nombre d'étapes limité
The discovery of neuropeptides as pharmacological active compounds is a breakthrough for our understanding in neurobiology. Neuropeptides can act as neurotransmetter, neuromodulators, and hormones. They control or influence a wide variety of biological behaviors (sexual, food intake, memory, learning, pain perception, ). Some of these peptides own to the family of RF-amide peptides which posses in their C-terminal part an arginine residue. In this work, we focused our interest on two peptides : neuropeptide FF (NPFF) and neuropeptide Y (NPY). Both of them have in their C-terminal part a RF-amide moiety. On one hand, our work was based on the study of structure activity relationship of a non specific ligand (BIBP 3226), which binds to both the NPY Y1 receptor and NPFF receptors. For this purpose, we had to optimize highly convergent synthetic methods both in solution and in solid phase in order to synthesize with high yields and purity arginine analogues and derivatives. Binding experiments highlighted two interesting hits : LPI 211 (Ki = 0,10 æM on NPFF1 and Ki = 0,16 æM on NPFF2) and LPI 214 (as antagonist of NPY on Y1 receptor). On the other hand, we have also performed an efficient method for the preparation of fluorescent arginine derivatives. These compounds were tested for their ability to produce FRET (5 %) on Y1 receptors in order to create a new high throughput screening method. Finally, we developed an original preparation of heterocyclic peptidomimetic compounds like dihydrotriazones by the use of Ugi four component reactions. This way of synthesis allowed us to obtain N1 substituted or N4 substituted dihydrotriazinones with a limited number of steps
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Bjellerup, Per. "Biochemical characterisation and clinical correlation of neuropeptides in neuroblastoma with emphasis on neuropeptide Y /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4524-1/.

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Dubin, Thierry. "Le neuropeptide Y dans le phéochromocytome : étude à partir d'une série de 15 cas." Bordeaux 2, 1990. http://www.theses.fr/1990BOR23098.

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McVeigh, P. "Neuropeptide signalling in nematodes." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411747.

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Morgan, David Alexander. "The role of neuropeptides Y and neuropeptide Y receptors in the control of carbohydrate metabolism." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267076.

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Books on the topic "Neuropeptide Y"

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F, Colmers William, and Wahlestedt Claes, eds. The Biology of neuropeptide Y and related peptides. Totowa, N.J: Humana Press, 1993.

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Irvine, G. Brent, and Carvell H. Williams. Neuropeptide Protocols. New Jersey: Humana Press, 1996. http://dx.doi.org/10.1385/0896033996.

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Gozes, Illana, ed. Neuropeptide Techniques. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-099-1.

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Brent, Irvine G., and Williams Carvell H, eds. Neuropeptide protocols. Totowa, N.J: Humana Press, 1997.

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author, Wardman Jonathan H., Stockton, Steven D., Jr., author, and Devi Lakshmi A. author, eds. Neuropeptide receptors. San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA): Morgan & Claypool, 2013.

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Viktor, Mutt, and Nobel Conference (Karolinska Institute) (1988 : Stockholm, Sweden), eds. Neuropeptide Y. New York: Raven Press, 1989.

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Balasubramaniam, Ambikaipakan. Neuropeptide Y Protocols. New Jersey: Humana Press, 2000. http://dx.doi.org/10.1385/159259042x.

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John, Turner Anthony, ed. Neuropeptide gene expression. London: Portland, 1994.

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Pawlikowski, M., and K. D. Döhler, eds. Progress in Neuropeptide Research. Basel: Birkhäuser Basel, 1989. http://dx.doi.org/10.1007/978-3-0348-5692-8.

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L, Strand Fleur, ed. Models of neuropeptide action. New York, N.Y: New York Academy of Sciences, 1994.

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Book chapters on the topic "Neuropeptide Y"

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Steiger, Axel. "Neuropeptide." In Springer Reference Medizin, 1–5. Berlin, Heidelberg: Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-642-54672-3_138-1.

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Hallberg, Mathias, Pierre Le Grevès, and Fred Nyberg. "Neuropeptide Processing." In Proteases In The Brain, 203–34. Boston, MA: Springer US, 2005. http://dx.doi.org/10.1007/0-387-23101-3_9.

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Andrews, Anne M., Greg A. Gerhardt, Lynette C. Daws, Mohammed Shoaib, Barbara J. Mason, Charles J. Heyser, Luis De Lecea, et al. "Neuropeptide Y." In Encyclopedia of Psychopharmacology, 855. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1209.

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Seth, John. "Neuropeptide Y." In The Immunoassay Kit Directory, 268–69. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1414-1_41.

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Kalra, Satya P., L. G. Allen, J. T. Clark, W. R. Crowley, and P. S. Kalra. "Neuropeptide Y." In Neural and Endocrine Peptides and Receptors, 353–66. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5152-8_24.

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Lolait, Stephen J., James A. Roper, Georgina G. J. Hazell, Yunfei Li, Fiona J. Thomson, and Anne-Marie O'Carroll. "Neuropeptide Receptors." In Molecular Neuroendocrinology, 195–215. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781118760369.ch10.

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Michel, Martin C. "Neuropeptide Y." In Encyclopedia of Molecular Pharmacology, 1–5. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-21573-6_99-1.

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Michel, Martin C. "Neuropeptide Y." In Encyclopedia of Molecular Pharmacology, 1104–7. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_99.

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Dangoor, David, Sara Rubinraut, Mati Fridkin, and Illana Gozes. "The Design, Synthesis, and Biological Evaluation of VIP and VIP Analogs." In Neuropeptide Techniques, 1–9. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-099-1_1.

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Hill, Joanna M., Maria A. Lim, and Madeleine M. Stone. "Developmental Milestones in the Newborn Mouse." In Neuropeptide Techniques, 131–49. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-60327-099-1_10.

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Conference papers on the topic "Neuropeptide Y"

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Malyutina, T. A. "NEUROPEPTIDES INVOLVING IN THE REGULATION OF LOCOMOTOR BEHAVIOR OF ROOT-KNOT PLANT-PARASITIC NEMATODES (REVIEW)." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV”, 2023. http://dx.doi.org/10.31016/978-5-6048555-6-0.2023.24.281-284.

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In the last few decades, the attention of researchers has been attracted by endogenous FMRFamide-like neuropeptides found in a number of invertebrates, including species of the Nematoda phylum. A foreign literature review was presented for the functional significance of endogenous FMRFamide-like neuropeptides in locomotor behaviour of root-knot phytonematodes, representatives of the genus Meloidogyne Goldi, 1982, namely, Meloidogyne incognita, M. minor, M. hapla and M. graminicola. In Russia, such studies are not carried out. The main characteristics of phytoparasitic neuropeptides were obtained from the study of genes (flp-genes) that encode these neuropeptides. M. incognita was found to have FMRFamidelike positive immunoreactivity in the central nervous system and 19 flp genes. The Mi-flp-12 and Mi-flp-14 genes encode neuropeptides that stimulate locomotor behaviour, while Mi-flp-32 encodes a neuropeptide that inhibits parasite locomotor behaviour. Nematodes M. incognita and M. hapla were found to have G-proteincoupled receptors (GPCRs) encoded by the flp-32 gene, and their similarity to receptor 1 (C26F1) of the free-living nematode Caenorhabditis elegans was detected. Similar data were presented in the literature for M. graminicola. The peptidergic signaling nervous system of root-knot phytonematodes is similar to the system of nematodes in vertebrates and free-living nematodes, which indicates the conservatism of the system in species of the entire Nematoda phylum.
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Kuznetsov, I. A., and A. V. Kuznetsov. "A Model of Neuropeptide Transport in Various Types of Nerve Terminals Containing En Passant Boutons: The Effect of the Rate of Neuropeptide Production in the Neuron Soma." In ASME 2015 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2015. http://dx.doi.org/10.1115/imece2015-50439.

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After being synthesized in the soma, neuropeptides are packaged in dense core vesicles (DCVs) and transported toward nerve terminals. It is known, from published experimental results, that in terminals with type Ib boutons DCVs circulate in the terminal, undergoing repeated anterograde and retrograde transport, while in type III terminals DCVs do not circulate in the terminal. Our goal here is to investigate whether the increased DCV production in the soma can lead to the appearance of DCV circulation in type III boutons. For this purpose we developed a mathematical model that simulates DCV transport in various terminals. Our model reproduces some important experimental results, such as those concerning DCV circulation in type Ib and type III terminals. We used the developed model to make testable predictions. The model predicts that an increased DCV production rate in the soma leads to increased DCV circulation in type Ib boutons and to the appearance of DCV circulation in type III boutons. The model also predicts that there are different stages in the development of DCV circulation in the terminals after they were depleted of DCVs due to neuropeptide release.
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Gruber, Christian. "Oxytocin-like neuropeptide signaling in invertebrates." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.94948.

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Zitnan, Dusan. "Neuropeptide regulation of reproductive behaviors inBombyx mori." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.105821.

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Pandit, Aniruddha A. "DINeR — A Database for Insect Neuropeptide Research." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.114365.

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Richardson, Hayley, Grace Maddocks, Kaila Peterson, Michael Daniele, and Spyridon Pavlidis. "Toward Subcutaneous Electrochemical Aptasensors for Neuropeptide Y." In 2021 IEEE Sensors. IEEE, 2021. http://dx.doi.org/10.1109/sensors47087.2021.9639832.

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Ewer, John. "Genetic dissection of neuropeptide-controlled behavior in Drosophila." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.105582.

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Fakira, Amanda, and Danya Aldaghma. "The neuropeptide receptor GPR83 regulates anxiety-like behavior." In ASPET 2024 Annual Meeting Abstract. American Society for Pharmacology and Experimental Therapeutics, 2024. http://dx.doi.org/10.1124/jpet.335.126229.

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Kreshchenko, N. D., and D. E. Mitkovskii. "THE PARTICIPATION OF NEUROPEPTIDE F IN THE INNERVATION OF FLATWORM MUSCULATE." In THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL. VNIIP – FSC VIEV, 2024. http://dx.doi.org/10.31016/978-5-6050437-8-2.2024.25.221-225.

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Free-living flatworms, planarians, are often used as a biological model to study the morphogenesis and regeneration processes, as well as structure and function of their muscle system. In this study, the spatial relationships between musculature and the nervous system were examined in planarians Girardia tigrina (Turbellaria, Platyhelminthes) using confocal laser scanning microscopy, histochemical staining of filamentous actin with fluorescently labelled phalloidin, and immunocytochemical staining of the nervous system with parasitic worm neuropeptide F antibodies. The body wall musculature contains three layers: an outer circular layer, an inner longitudinal layer, and a layer of rare diagonal muscle fibers in-between running in two perpendicular directions. The results showed that the body wall musculature was intensively supplied with NPF-immunopositive (-IP) nerve fibers. Thus, NPF-IP nerve fibers were localized in the body wall muscle layer of worms including the tail region musculature. Such identification of NPF-IP neurons and its endings near the somatic muscle fibers of the body wall may indicate the potential neuropeptide F participation in the muscle contractility regulation in flatworms.
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Lee, Kyu, Robert Magnusson, Brett R. Wenner, Jeffery W. Allen, and Monica S. Allen. "Neuropeptide Y Binding Dynamics Quantified with Nanophotonic Resonant Sensors." In 2018 IEEE Research and Applications of Photonics In Defense Conference (RAPID). IEEE, 2018. http://dx.doi.org/10.1109/rapid.2018.8508979.

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Reports on the topic "Neuropeptide Y"

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Nulk, Matthew, William Schuh, Lolita M. Burrell, and Michael D. Matthews. Effects of Neuropeptide Y on Resilience to PTSD. Fort Belvoir, VA: Defense Technical Information Center, April 2011. http://dx.doi.org/10.21236/ada540854.

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Iwase, Akira. Neutral Endopeptidase Inhibits Neuropeptide Medicated Growth of Androgen-Independent Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada404915.

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Lee, Che-Hung, Robert Brown, Elizabeth A. Jajane, and Hsiu-Ying T. Yang. Monoclonal Antibody to an Endogenous Neuropeptide with Putative Morphine-Modulating Activity. Fort Belvoir, VA: Defense Technical Information Center, December 1988. http://dx.doi.org/10.21236/ada205386.

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Sachdeva, Mandip S. The Effect of Jet Fuels on the Skin Irritation and Neuropeptide Release. Fort Belvoir, VA: Defense Technical Information Center, December 2003. http://dx.doi.org/10.21236/ada424424.

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Rafaeli, Ada, Russell Jurenka, and Daniel Segal. Isolation, Purification and Sequence Determination of Pheromonotropic-Receptors. United States Department of Agriculture, July 2003. http://dx.doi.org/10.32747/2003.7695850.bard.

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Moths constitute a major group of pest insects in agriculture. Pheromone blends are utilised by a variety of moth species to attract conspecific mates, which is under circadian control by the neurohormone, PBAN (pheromone-biosynthesis-activating neuropeptide). Our working hypothesis was that, since the emission of sex-pheromone is necessary to attract a mate, then failure to produce and emit pheromone is a potential strategy for manipulating adult moth behavior. The project aimed at identifying, characterising and determining the sequence of specific receptors responsible for the interaction with pheromonotropic neuropeptide/s using two related moth species: Helicoverpa armigera and H. lea as model insects. We established specific binding to a membrane protein estimated at 50 kDa in mature adult females using a photoaffinity-biotin probe for PBAN. We showed that JH is required for the up-regulation of this putative receptor protein. In vitro studies established that the binding initiates a cascade of second messengers including channel opening for calcium ions and intracellular cAMP production. Pharmacological studies (using sodium fluoride) established that the receptor is coupled to a G-protein, that is, the pheromone-biosynthesis-activating neuropeptide receptor (PBAN-R) belongs to the family of G protein-coupled receptor (GPCR)'s. We showed that PBAN-like peptides are present in Drosophila melanogaster based on bioassay and immunocytochemical data. Using the annotated genome of D. melanogaster to search for a GPCR, we found that some were similar to neuromedin U- receptors of vertebrates, which contain a similar C-terminal ending as PBAN. We established that neuromedin U does indeed induce pheromone biosynthesis and cAMP production. Using a PCR based cloning strategy and mRNA isolated from pheromone glands of H. zea, we successfully identified a gene encoding a GPCR from pheromone glands. The full-length PBAN-R was subsequently cloned and expressed in Sf9 insect cells and was shown to mobilize calcium in response to PBAN in a dose-dependent manner. The successful progress in the identification of a gene, encoding a GPCR for the neurohormone, PBAN, provides a basis for the design of a novel battery of compounds that will specifically antagonize pheromone production. Furthermore, since PBAN belongs to a family of insect neuropeptides with more than one function in different life stages, this rationale may be extended to other physiological key-regulatory processes in different insects.
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Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, August 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

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The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist biophores (ii) to develop an arsenal of amphiphilic topically active PK/PBAN antagonists with an array of different time-release profiles based on the previously developed prototype analog; (iii) to develop rationally designed non-peptide SMLs based on the antagonist biophore determined in (i) and evaluate them in cloned receptor microplate binding assays and by pheromonotropic, melanotropic and pupariation in vivo assays. (iv) to clone PK/PBAN receptors (PK/PBAN-Rs) for further understanding of receptor-ligand interactions; (v) to develop microplate binding assays for screening the above SMLs. In the course of the granting period A series of amphiphilic PK/PBAN analogs based on a linear lead antagonist from the previous BARD grant was synthesized that incorporated a diverse array of hydrophobic groups (HR-Suc-A[dF]PRLa). Others were synthesized via the attachment of polyethylene glycol (PEG) polymers. A hydrophobic, biostablePK/PBAN/DH analog DH-2Abf-K prevented the onset of the protective state of diapause in H. zea pupae [EC50=7 pmol/larva] following injection into the preceding larval stage. It effectively induces the crop pest to commit a form of ‘ecological suicide’. Evaluation of a set of amphiphilic PK analogs with a diverse array of hydrophobic groups of the formula HR-Suc-FTPRLa led to the identification of analog T-63 (HR=Decyl) that increased the extent of diapause termination by a factor of 70% when applied topically to newly emerged pupae. Another biostablePK analog PK-Oic-1 featured anti-feedant and aphicidal properties that matched the potency of some commercial aphicides. Native PK showed no significant activity. The aphicidal effects were blocked by a new PEGylated PK antagonist analog PK-dF-PEG4, suggesting that the activity is mediated by a PK/PBAN receptor and therefore indicative of a novel and selective mode-of-action. Using a novel transPro mimetic motif (dihydroimidazole; ‘Jones’) developed in previous BARD-sponsored work, the first antagonist for the diapause hormone (DH), DH-Jo, was developed and shown to block over 50% of H. zea pupal diapause termination activity of native DH. This novel antagonist development strategy may be applicable to other invertebrate and vertebrate hormones that feature a transPro in the active core. The research identifies a critical component of the antagonist biophore for this PK/PBAN receptor subtype, i.e. a trans-oriented Pro. Additional work led to the molecular cloning and functional characterization of the DH receptor from H. zea, allowing for the discovery of three other DH antagonist analogs: Drosophila ETH, a β-AA analog, and a dF analog. The receptor experiments identified an agonist (DH-2Abf-dA) with a maximal response greater than native DH. ‘Deconvolution’ of a rationally-designed nonpeptide heterocyclic combinatorial library with a cyclic bis-guanidino (BG) scaffold led to discovery of several members that elicited activity in a pupariation acceleration assay, and one that also showed activity in an H. zea diapause termination assay, eliciting a maximal response of 90%. Molecular cloning and functional characterization of a CAP2b antidiuretic receptor from the kissing bug (R. prolixus) as well as the first CAP2b and PK receptors from a tick was also achieved. Notably, the PK/PBAN-like receptor from the cattle fever tick is unique among known PK/PBAN and CAP2b receptors in that it can interact with both ligand types, providing further evidence for an evolutionary relationship between these two NP families. In the course of the granting period we also managed to clone the PK/PBAN-R of H. peltigera, to express it and the S. littoralis-R Sf-9 cells and to evaluate their interaction with a variety of PK/PBAN ligands. In addition, three functional microplate assays in a HTS format have been developed: a cell-membrane competitive ligand binding assay; a Ca flux assay and a whole cell cAMP ELISA. The Ca flux assay has been used for receptor characterization due to its extremely high sensitivity. Computer homology studies were carried out to predict both receptor’s SAR and based on this analysis 8 mutants have been generated. The bioavailability of small linear antagonistic peptides has been evaluated and was found to be highly effective as sex pheromone biosynthesis inhibitors. The activity of 11 new amphiphilic analogs has also been evaluated. Unfortunately, due to a problem with the Heliothis moth colony we were unable to select those with pheromonotropic antagonistic activity and further check their bioavailability. Six peptides exhibited some melanotropic antagonistic activity but due to the low inhibitory effect the peptides were not further tested for bioavailability in S. littoralis larvae. Despite the fact that no new antagonistic peptides were discovered in the course of this granting period the results contribute to a better understanding of the interaction of the PK/PBAN family of Nps with their receptors, provided several HT assays for screening of libraries of various origin for presence of PK/PBAN-Ragonists and antagonists and provided important practical information for the further design of new, peptide-based insecticide prototypes aimed at the disruption of key neuroendocrine physiological functions in pest insects.
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Clayton, Brian, Christopher Brown, Lolita Burrell, and Michael Matthews. The Use of Neuropeptide Y as a Measurement of the Effectiveness of Stress Inoculation. Fort Belvoir, VA: Defense Technical Information Center, April 2011. http://dx.doi.org/10.21236/ada540922.

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Richards, Daelyn. Neuropeptide Y: A potential Marker for a Life-History Transition in the Red-Sided Garter Snake (Thamnophis sirtalis parietalis). Portland State University Library, January 2014. http://dx.doi.org/10.15760/honors.104.

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Thiele, Todd E., Darin J. Knapp, George Breese, and Thomas J. McCown. The Role Of Neuropeptide Y (Npy) in Uncontrolled Alcohol Drinking and Relapse Behavior Resulting from Exposure to Stressful Events. Fort Belvoir, VA: Defense Technical Information Center, January 2009. http://dx.doi.org/10.21236/ada594088.

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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, October 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and pupariation activities; (ii) Test the inhibitory potencies of the BBC compounds on the above activities evoked either by synthetic peptides (PBAN, LPK, myotropin and pheromonotropin) or by the natural endogenous mechanism; (iii) Determine the bioavailability of the most potent BBC compounds that will be found in (ii); (iv) Design, synthesize and examine novel PK/PBAN analogs with enhanced bioavailability and receptor binding; (v) Design and synthesize ‘magic bullet’ analogs and examine their ability to selectively kill cells expressing the PK/PBAN receptor. To achieve these goals the agonistic and antagonistic activities/properties of rationally designed linear and BBC neuropeptide (NP) were thoroughly studied and the information obtained was further used for the design and synthesis of improved compounds toward the design of an insecticide prototype. The study revealed important information on the structure activity relationship (SAR) of agonistic/antagonistic peptides, including definitive identification of the orientation of the Pro residue as trans for agonist activity in 4 PK/PBANbioassays (pheromonotropic, pupariation, melanotropic, & hindgut contractile) and a PK-related CAP₂b bioassay (diuretic); indications that led to the identification of a novel scaffold to develop biostbiostable, bioavailable peptidomimetic PK/PBANagonists/antagonists. The work led to the development of an arsenal of PK/PBAN antagonists with a variety of selectivity profiles; whether between different PKbioassays, or within the same bioassay between different natural elicitors. Examples include selective and non-selective BBC and novel amphiphilic PK pheromonotropic and melanotropic antagonists some of which are capable of penetrating the moth cuticle in efficacious quantities. One of the latter analog group demonstrated unprecedented versatility in its ability to antagonize a broad spectrum of pheromonotropic elicitors. A novel, transPro mimetic motif was proposed & used to develop a strong, selective PK agonist of the melanotropic bioassay in moths. The first antagonist (pure) of PK-related CAP₂b diuresis in flies was developed using a cisPro mimetic motif; an indication that while a transPro orientation is associated with receptor agonism, a cisPro orientation is linked with an antagonist interaction. A novel, biostablePK analog, incorporating β-amino acids at key peptidase-susceptible sites, exhibited in vivo pheromonotropic activity that by far exceeded that of PBAN when applied topically. Direct analysis of neural tissue by state-of-the-art MALDI-TOF/TOF mass spectrometry was used to identify specific PK/PK-related peptides native to eight arthropod pest species [house (M. domestica), stable (S. calcitrans), horn (H. irritans) & flesh (N. bullata) flies; Southern cattle fever tick (B. microplus), European tick (I. ricinus), yellow fever mosquito (A. aegypti), & Southern Green Stink Bug (N. viridula)]; including the unprecedented identification of mass-identical Leu/Ile residues and the first identification of NPs from a tick or the CNS of Hemiptera. Evidence was obtained for the selection of Neb-PK-2 as the primary pupariation factor of the flesh fly (N. bullata) among native PK/PK-related candidates. The peptidomic techniques were also used to map the location of PK/PK-related NP in the nervous system of the model fly D. melanogaster. Knowledge of specific PK sequences can aid in the future design of species specific (or non-specific) NP agonists/antagonists. In addition, the study led to the first cloning of a PK/PBAN receptor from insect larvae (S. littoralis), providing the basis for SAR analysis for the future design of 2ⁿᵈgeneration selective and/or nonselective agonists/antagonists. Development of a microplate ligand binding assay using the PK/PBAN pheromone gland receptor was also carried out. The assay will enable screening, including high throughput, of various libraries (chemical, molecular & natural product) for the discovery of receptor specific agonists/antagonists. In summary, the body of work achieves several key milestones and brings us significantly closer to the development of novel, environmentally friendly pest insect management agents based on insect PK/PBANNPs capable of disrupting critical NP-regulated functions.
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