Academic literature on the topic 'Neuronal cell loss'
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Journal articles on the topic "Neuronal cell loss"
Fricker, Michael, Aviva M. Tolkovsky, Vilmante Borutaite, Michael Coleman, and Guy C. Brown. "Neuronal Cell Death." Physiological Reviews 98, no. 2 (April 1, 2018): 813–80. http://dx.doi.org/10.1152/physrev.00011.2017.
Full textSugawara, Mitsuru, Gabriel Corfas, and M. Charles Liberman. "Influence of Supporting Cells on Neuronal Degeneration After Hair Cell Loss." Journal of the Association for Research in Otolaryngology 6, no. 2 (June 2005): 136–47. http://dx.doi.org/10.1007/s10162-004-5050-1.
Full textSmith, Ruben, Hinfan Chung, Sara Rundquist, Marion L. C. Maat-Schieman, Lesley Colgan, Elisabet Englund, Yong-Jian Liu, et al. "Cholinergic neuronal defect without cell loss in Huntington's disease." Human Molecular Genetics 15, no. 21 (September 20, 2006): 3119–31. http://dx.doi.org/10.1093/hmg/ddl252.
Full textTakács-Vellai, Krisztina, Andrew Bayci, and Tibor Vellai. "Autophagy in neuronal cell loss: a road to death." BioEssays 28, no. 11 (2006): 1126–31. http://dx.doi.org/10.1002/bies.20489.
Full textAbad-Rodriguez, Jose, Maria Dolores Ledesma, Katleen Craessaerts, Simona Perga, Miguel Medina, Andre Delacourte, Colin Dingwall, Bart De Strooper, and Carlos G. Dotti. "Neuronal membrane cholesterol loss enhances amyloid peptide generation." Journal of Cell Biology 167, no. 5 (December 6, 2004): 953–60. http://dx.doi.org/10.1083/jcb.200404149.
Full textKranenburg, O., V. Scharnhorst, A. J. Van der Eb, and A. Zantema. "Inhibition of cyclin-dependent kinase activity triggers neuronal differentiation of mouse neuroblastoma cells." Journal of Cell Biology 131, no. 1 (October 1, 1995): 227–34. http://dx.doi.org/10.1083/jcb.131.1.227.
Full textOue, Hiroshi, Yasunari Miyamoto, Shinsuke Okada, Katsunori Koretake, Cha-Gyun Jung, Makoto Michikawa, and Yasumasa Akagawa. "Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice." Behavioural Brain Research 252 (September 2013): 318–25. http://dx.doi.org/10.1016/j.bbr.2013.06.015.
Full textKorwitz, Anne, Carsten Merkwirth, Ricarda Richter-Dennerlein, Simon E. Tröder, Hans-Georg Sprenger, Pedro M. Quirós, Carlos López-Otín, Elena I. Rugarli, and Thomas Langer. "Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria." Journal of Cell Biology 212, no. 2 (January 18, 2016): 157–66. http://dx.doi.org/10.1083/jcb.201507022.
Full textTang, Damu, Isao Matsuura, Jerry H. Wang, Ki-Young Lee, and Zhong Qi. "Neuronal Cdc2-like kinase: from cell cycle to neuronal function." Biochemistry and Cell Biology 74, no. 4 (July 1, 1996): 419–29. http://dx.doi.org/10.1139/o96-046.
Full textLu, Jian-Qiang, Trevor A. Steve, Matt Wheatley, and Donald W. Gross. "Immune Cell Infiltrates in Hippocampal Sclerosis: Correlation With Neuronal Loss." Journal of Neuropathology & Experimental Neurology 76, no. 3 (March 2017): 206–15. http://dx.doi.org/10.1093/jnen/nlx001.
Full textDissertations / Theses on the topic "Neuronal cell loss"
Brown, Deborah A. "Mechanisms of neurodegeneration and neuronal cell loss in the hippocampus in murine scrapie." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4422.
Full textSuzzi, Stefano. "Loss of lrrk2 impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brain." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-229200.
Full textSuzzi, Stefano [Verfasser], Michael [Akademischer Betreuer] Brand, and Gerd [Gutachter] Kempermann. "Loss of lrrk2 impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brain / Stefano Suzzi ; Gutachter: Michael Brand, Gerd Kempermann ; Betreuer: Michael Brand." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-229200.
Full textSuzzi, Stefano [Verfasser], Michael [Akademischer Betreuer] [Gutachter] Brand, and Gerd [Gutachter] Kempermann. "Loss of lrrk2 impairs dopamine catabolism, cell proliferation, and neuronal regeneration in the zebrafish brain / Stefano Suzzi ; Gutachter: Michael Brand, Gerd Kempermann ; Betreuer: Michael Brand." Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://d-nb.info/114073525X/34.
Full textTodd, Michael. "The effects of multiple ischemia and survival times on hippocampal CA1 neuronal cell loss in a rat model of global ischemia: A long-term ischemia maturation study." Thesis, University of Ottawa (Canada), 1998. http://hdl.handle.net/10393/4230.
Full textTodd, Mike. "The effects of multiple ischemia and survival times on hippocampal CA1 neuronal cell loss in a rat model of global ischemia, a long-term ischemia maturation study." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ36746.pdf.
Full textBezuidenhout, Lois-Mary. "Triquinylamines as regulators of calcium homeostasis of neuronal cells / Lois-Mary Bezuidenhout." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1470.
Full textVoisin, Jessica. "Rôle de FOXO3 dans la régulation des phases précoces de la maladie de Huntington lors de la différenciation neuronale." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066613/document.
Full textFOXO3 is an important transcription factor for stress response, the regulation of differentiation and cell survival that has neuroprotective effects in several models of neurodegenerative diseases, including Huntington’s disease (HD). The neuroprotective effects of FOXO3 in HD are repressed by abnormal signaling from the Wnt receptor Ryk by the binding of the intracellular domain of Ryk to the β-catenin, a cofactor of FOXO3.The aim of this work was to explore the effect of the mutant huntingtin (mHTT) on the repertoire of direct FOXO3 targets (F3Ts) using a model of developmental stage of HD, namely HD isogenic neural stem cells derived from Huntington’s Induced Pluripotent Stem cells. Forming a tripartite complex with β-catenin and FOXO3, Ryk acts as a co-regulator of FOXO3 in normal or pathological condition. Analysis of direct FOXO3 targets shows reprogramming of these targets with losses and gains in signaling pathways that are known to role in HD, including regulatory pathways of cell proliferation. These results show that gene regulation by FOXO3 is heavily modified in cells expressing the mutant huntingtin. Our findings open the way for a comprehensive study of cellular homeostasis mechanisms under the control of FOXO3 in neural differentiation and their impact on the activity of adult neurons. More broadly, these results provide insight into the molecular dynamics of MH and the effects of molecular reprogramming in differentiation and neuronal activity
Freitas, Ana Maria Salgueiro. "Effects of ataxins-3 loss and gain of function : characterization of neuronal cell lines overexpressing wild-type and mutant forms of mutant ataxin-3." Master's thesis, 2013. http://hdl.handle.net/1822/27817.
Full textMachado-Joseph Disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is an autosomal dominant neurodegenerative disorder which involves the cerebellar, pyramidal, extrapyramidal, motor neuron and oculomotor systems. MJD is caused by an expanded CAG repeat in the coding region of the ataxin-3 gene; for this reason it belongs to the group of polyglutamine (polyQ) associated diseases. The normal function of the ataxin-3 protein (ATXN3) remains mostly unknown, although there are some data suggesting a role for this protein in the modulation of protein degradation (either by the UPS or through autophagy) in association with its deubiquitylase (DUB) activity. Other evidence suggests a role in transcription regulation, in the cellular response(s) to stress and in the cytoskeleton organization as well as in cellular adhesion. In this work we studied the normal function of ATXN3 in neurons, using a novel neuroblastoma SH-SY5Y cell-based approach. We characterized all the different cell lines, assessing cell differentiation and survival, morphology, adhesion and cytoskeleton features, in cells overexpressing wild-type (ATXN3_28Q) and expanded (ATXN3_83Q) ATXN3 as well as cells expressing a catalytic mutant version of this protein (ATXN3_C14A). We also evaluated the transcriptomic profile and protein expression of the cell lines and further investigated the pathways underlying the cellular changes and cytoskeletal regulators. Moreover, in cells expressing both mutant and expanded ATXN3, we found a decreased expression of α-5 integrin (ITGA5) and inhibition of its downstream partners’ activity. The findings described in this study led us to hypothesize that the DUB activity of ATXN3 underlie the neuronal phenotype regulation and also that the expansion of the polyQ tract causes partial loss of function.
A doença de Machado-Joseph (DMJ), também conhecida como ataxia espinocerebelar 3, é uma desordem autossómica dominante que envolve os sistemas cerebelar, piramidal, extrapiramidal, motor neuronal e oculomotor. A DMJ é causada por uma expansão no codão CAG na região codificante do gene da ataxina-3; por esta razão, pertence ao grupo das doenças associadas às poliglutaminas (poliQ). A função normal da proteína ataxina-3 permanece desconhecida, embora alguns dados sugiram um papel da modulação da degradação proteica (quer pelo UPS ou por autofagia) em associação com a sua actividade como deubiquitilase (DUB). Outras evidências apontam para funções relacionadas com regulação da transcrição, como resposta celular ao stress, no citoesqueleto e adesão celular. Neste trabalho estudámos a função normal da ATXN3 em neurónios, usando uma nova abordagem com uma linha neuronal SY5Y de neuroblastoma. Caracterizámos as diferentes linhas celulares, nomeadamente diferenciação celular e sobrevida, morfologia, propriedades de adesão e citoesqueleto em células sobreexpressando a estirpe selvagem da ATXN3 (ATXN3_28Q), a forma expandida (ATXN3_83Q) assim como células sobre-expressando uma versão catalítica mutante (ATXN3_C14A) desta proteína. Avaliámos as diferenças na expressão transcripcional e proteica entre as linhas celulares e investigámos quais as vias de sinalização envolvidas nas alterações celulares observadas e reguladores do citoesqueleto. As células sobre-expressando ambas as formas mutante e expandida, da proteína apresentaram uma expressão diminuída da α5 integrina (ITGA5) bem como uma inibição da actividade desta proteína ao longo da via. As evidências resultantes deste estudo levaram-nos a colocar a hipótese que a actividade DUB da ATXN3 está na base da regulação do fenótipo neuronal e também que a expansão do tracto de poliglutaminas causa uma perda parcial da função da ataxina-3.
Books on the topic "Neuronal cell loss"
Soileau, Michael J., and Kelvin L. Chou. Parkinson Disease. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0002.
Full textLees, A. J. Parkinson’s disease. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199658602.003.0008.
Full textSchaible, Hans-Georg, and Rainer H. Straub. Pain neurophysiology. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0059.
Full textCummings, Jeffrey L., and Jagan A. Pillai. Neurodegenerative Diseases. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190233563.003.0001.
Full textFink, John K. Upper Motor Neuron Disorders. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0031.
Full textFerraiuolo, Laura, and Stephen J. Kolb. Amyotrophic Lateral Sclerosis. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0026.
Full textStraub, Rainer H. Neuroendocrine system. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0022.
Full textStraub, Rainer H. Neuroendocrine system. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0022_update_002.
Full textStraub, Rainer H. Neuroendocrine system. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199642489.003.0022_update_003.
Full textEhrlich, Benjamin. The Dreams of Santiago Ramón y Cajal. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190619619.001.0001.
Full textBook chapters on the topic "Neuronal cell loss"
Liberman, M. Charles. "Noise-Induced Hearing Loss: Permanent Versus Temporary Threshold Shifts and the Effects of Hair Cell Versus Neuronal Degeneration." In The Effects of Noise on Aquatic Life II, 1–7. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2981-8_1.
Full textLopez-Gutierrez, Javier, and B. Mario Cervantes. "Achalasia." In Mastering Endo-Laparoscopic and Thoracoscopic Surgery, 201–6. Singapore: Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3755-2_31.
Full textNitsch, C., B. Eiche, J. Ulrich, and D. Monard. "On the Role of Glia-Derived Protease Nexin-1 in Neuronal and Glial Adaptation to Ischemia-Induced Cell Loss in Human Brain." In Maturation Phenomenon in Cerebral Ischemia II, 151–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60546-8_19.
Full textYadav, Divyansh, and Seema Nara. "Nanozymes for Neurodegenerative Diseases." In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022), 77–95. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_9.
Full textSwaab, D. F., E. Fliers, and E. Goudsmit. "Differential Cell Loss in (Peptide) Neurons in the Anterior Hypothalamus with Aging and Alzheimer’s Disease: Lack of Changes in Cell Density." In Neurology, 119–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70007-1_14.
Full textRubin, Devon I. "Basics of Neurophysiology." In Clinical Neurophysiology, edited by Devon I. Rubin, C1—C1.P35. 5th ed. Oxford University PressNew York, 2021. http://dx.doi.org/10.1093/med/9780190067854.003.0002.
Full textD. Udovin, Lucas, Andrea Aguilar, Tamara Kobiec, María I. Herrera, Santiago Perez Lloret, Nicolás Toro Urrego, and Rodolfo A. Kölliker Frers. "Neuroprotective Properties of Cannabinoids in Cellular and Animal Models: Hypotheses and Facts." In Neuroprotection - New Approaches and Prospects. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.90761.
Full textHoward, Gary C. "Death of Cells." In The Biology of Death, 131–51. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780190687724.003.0008.
Full textFoster, Paul J., Anthony Khawaja, Lisanne J. Balk, Zaynah Muthy, and Axel Petzold. "Sensory loss—vision." In Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology, edited by Carol Brayne, Valery L. Feigin, Lenore J. Launer, and Giancarlo Logroscino, 345–54. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198749493.003.0033.
Full textSchaible, Hans-Georg, and Rainer H. Straub. "Pain neurophysiology." In Oxford Textbook of Rheumatology, 431–36. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0059_update_002.
Full textConference papers on the topic "Neuronal cell loss"
Cao, Guoxin, You Zhou, Jeong Soon Lee, Jung Yul Lim, and Namas Chandra. "Mechanical Model of Neuronal Function Loss." In ASME 2010 International Mechanical Engineering Congress and Exposition. ASMEDC, 2010. http://dx.doi.org/10.1115/imece2010-39447.
Full textPark, Sunghee E., Kang-Il Song, Jun-Kyo F. Suh, and Inchan Youn. "Characteristics of the neuronal firing patterns in the subthalamic nucleus with graded dopaminergic cell loss in the nigrostriatal pathway." In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7318902.
Full textValdes, Alberto, Alejandro Cifuentes, Jose David Sanchez-Martinez, Miguel Herrero, Rocio Gallego, and Zully Suarez-Montenegro. "Foodomics study of the neuroprotective potential of natural products." In 2022 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2022. http://dx.doi.org/10.21748/bdyo8801.
Full textGuelli, Mariana Sandoval Terra Campos, Daniela Bastos de Almeida Zampier, Lorena Araújo Silva Dias, and Marina de Oliveira Nunes Ibrahim. "Creutzfeldt-Jakob Disease - a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.126.
Full textSilva, Gustavo Figueiredo da, Caroline Figueiredo da Silva, Washigton Luiz Gomes de Medeiros Junior, and Marcus Vinícius Magno Gonçalves. "Anti -Iglon5 Syndrome: What we know so far? A non-systematic review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.237.
Full textLee, Sung Jin, Jingjing Sun, Michael King, Huikai Xie, and Malisa Sarntinoranont. "Viscoelastic Property Changes of Acute Rat Brain Tissue Slices as a Function of Cell Viability." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53909.
Full textAraldi, Bianca Barbosa, Victor Hugo Gomes, Bruno Ludvig Vieira, Klesia Adayani Rodrigues, Andressa Gabrieli da Silva, Leticia Scolari, Gabriela Vasconcellos Santana, Jessica Marafiga, Maria Paula Carvalho, and Heloise Helena Siqueira. "Effects of multiple sclerosis in pregnant and post-birth: particularities of the disease activity." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.704.
Full textOmar, Hamzeh W., and Harini G. Sundararaghavan. "Effects of Cytoskeletal Tension on Chick Dorsal Root Ganglia." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14585.
Full textVandaele, Mathieu, Bryan S. Joyce, and Pablo A. Tarazaga. "Design and Characterization of Piezo-Based Stereocilia." In ASME 2013 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/smasis2013-3189.
Full textGonçalo, Ana Clara Mota, and Kaline dos Santos Kishishita Castro. "Treatment and main complications of Amyotrophic Lateral Sclerosis: a literature review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.520.
Full textReports on the topic "Neuronal cell loss"
Kamaruzzaman, Mohd Amir, Muhammad Hibatullah Romli, Razif Abas, Sharmili Vidyadaran, Mohamad Taufik Hidayat Baharuldin, Muhammad Luqman Nasaruddin, Vishnnumukkala Thirupathirao, et al. Impact of Endocannabinoid Mediated Glial Cells on Cognitive Function in Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Animal Studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, August 2022. http://dx.doi.org/10.37766/inplasy2022.8.0094.
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