Dissertations / Theses on the topic 'Neurogenesis'
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Charbord, Jérémie. "Criblage à haut débit d'inhibiteurs du répresseur de transcription REST dans des progénies neurales issues de cellules souches embryonnaires humaines." Thesis, Evry-Val d'Essonne, 2012. http://www.theses.fr/2012EVRY0004.
Full textOur goal was to identify pharmacological inhibitors of REST that would be able to increase the expression of a set of neuronal gene targets of REST (RE1 genes) in human neural stem cells (NSCS) derived from human embryonic stem cells (HESC). These compounds would at first provide a new type of tool to better understand REST action on proliferation and differentiation in normal or pathological NSCS and could have therapeutical properties for diseases in which an over-activation of REST is implicated in or influences cellular pathology such as huntington’s disease or some brain tumors. Identification of REST inhibitors was performed using the powerful technology of high throughput screening (HTS). Success of this method was based on the set up of a robust functional cell assay of REST activity in NSCS. A reporter system of this activity has been constructed using an expression cassette of the renilla luciferase placed under control of a strong constitutive promoter. Several RE1 sites have been inserted upstream of this cassette to make the expression of Luciferase dependent on REST activity. We have isolated x5050 compound, a benzimidazole which leads to upregulation of RE1 genes as shown by transcriptomic studies. x5050 modified neither rest transcription nor rest fixation on a labeled nucleotidic RE1 sequence. On the contrary, x5050 treatment induced the decrease in rest protein level, probably by modulating REST degradation by the ubiquitin-proteasome system
Sandberg, Magnus. "Sox proteins and neurogenesis." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-873-0/.
Full textBrill, Monika. "Regionalization of adult neurogenesis." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-101449.
Full textAaku-Saraste, E. (Eeva). "A prelude to neurogenesis." Doctoral thesis, University of Oulu, 1999. http://urn.fi/urn:isbn:9514253655.
Full textTosti, Claudia. "NEUROGENESIS IN UTERINE DISORDERS." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1095599.
Full textVaculik, Michael. "Beclin1 Regulates Adult Hippocampal Neurogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32994.
Full textDhaliwal, Jagroop. "Regulators of Adult Hippocampal Neurogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35712.
Full textTeutenberg, Kevin. "Glucose, glucose transporters and neurogenesis." Thesis, University of Ottawa (Canada), 2008. http://hdl.handle.net/10393/28026.
Full textWright, Rupert. "Engineering surfaces to control neurogenesis." Thesis, Keele University, 2015. http://eprints.keele.ac.uk/2350/.
Full textLyons, David Anthony. "Neurogenesis in the zebrafish hindbrain." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407357.
Full textHowell, Owain W. "Neuropeptide Y modulates hippocampal neurogenesis." Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403849.
Full textRooney, Alasdair Grant. "Matrix signalling and hippocampal neurogenesis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33168.
Full textTata, M. A. J. "Vascular regulation of embryonic neurogenesis." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1531030/.
Full textAttardo, Alessio. "Novel in vivo imaging approaches to study embryonic and adult neurogenesis in the mouse." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2007. http://nbn-resolving.de/urn:nbn:de:swb:14-1169813208146-70320.
Full textAttardo, Alessio. "Novel in vivo imaging approaches to study embryonic and adult neurogenesis in the mouse." Doctoral thesis, Technische Universität Dresden, 2006. https://tud.qucosa.de/id/qucosa%3A25037.
Full textKaslin, Jan, and Michael Brand. "Cerebellar Development and Neurogenesis in Zebrafish." Springer, 2013. https://tud.qucosa.de/id/qucosa%3A33555.
Full textZhang, Yifei. "Fred Regulatory Network in Drosophila Neurogenesis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1332015401.
Full textOverall, Rupert. "Modelling genetic networks involved in the activity-dependent modulation of adult neurogenesis." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-164782.
Full textNeurogenesis, the production of new neurons, is restricted in the adult brain of mammals to only a few regions. One of these sites of adult neurogenesis is the hippocampus, a structure essential for many types of learning. A pool of stem cells is maintained in the subgranular zone of the hippocampal dentate gyrus which proliferate and can differentiate into new neurons, astrocytes and oligodendroctytes. Regulation of adult hippocampal neurogenesis occurs in response to en- vironmental stimuli and is under the control of many genes. This work employs high-throughput gene expression technologies to identify these genes and their interactions with each other and the neurogenesis phenotype. Harnessing variation from genetic, environmental and temporal sources, a multi-faceted dataset has been generated which offers a multidimensional view of the neural precursor proliferation phenotype. Networks of gene-gene and gene-phenotype interac- tions have been described and merged into a multilayer resource. A core subnetwork derived from modules recurring in the different layers has been identified using the proliferation phenotype as a seed. This subnetwork has suggested novel genes and interactions potentially involved in the regulation of adult hippocampal neurogenesis
Wells, Layne. "Investigating Neurogenesis as a Veritable Epigenetic Endophenotype for Alzheimer's Disease." Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/scripps_theses/1232.
Full textCrews, Leslie Anne. "Molecular regulators of neurogenesis in Alzheimer's disease." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3398251.
Full textTitle from first page of PDF file (viewed May 6, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (leaves 196-218).
Fargas, Madriles Laura 1989. "Morphogenetic mechanisms in zebrafish inner ear neurogenesis." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/397795.
Full textThe vertebrate inner ear is a highly ordered and complex structure, in which specialized cell types originate at distinct but specific domains. Therefore, patterning and cell fate specification must be coupled with morphogenesis of the entire organ. In this work we analyze in detail the spatiotemporal regulation of the formation of the inner ear sensory and neurogenic domains and the relation of proneural genes and Notch signaling. Although several studies have reported the expression of proneural genes and specification of neuronal progenitors, the dynamics of neurogenesis and cell behaviors involved in this process are still elusive. Moreover, we focus in more detail on the formation of the neurogenic domain. We perform a dynamic quantification of proneural gene expression combined with a 4D analysis of cell behaviors, and unveil the mechanisms of initiation of otic neurogenesis, which relies on both cell dynamics and FGF pathway.
Alspector, Emily Bitler Elizabeth. "The relationship between neurogenesis and pain behavior." Diss., Connect to the thesis, 2008. http://hdl.handle.net/10066/1325.
Full textMayor, Olivier. "Lineage analysis of neurogenesis in mouse chimera." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=59410.
Full textZaben, Malik J. "Vasoactive Intestinal Peptide : Control of Hippocampal Neurogenesis." Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509485.
Full textBorders, Aaron S. "THE ROLE OF MACROPHAGES IN OLFACTORY NEUROGENESIS." UKnowledge, 2007. http://uknowledge.uky.edu/physiology_etds/15.
Full textJafari, Mehrnoosh. "Disease-associated modulation of adult hippocampal neurogenesis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-174174.
Full textChoi, Minee. "Adult neurogenesis and dopamine in neurodegenerative diseases." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607778.
Full textCenci, Caterina. "Regulation of segment-specific neurogenesis in Drosophila." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446838/.
Full textGriffiths, Dean Stuart. "Molecular characterisation of embryonic stem cell neurogenesis." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/13958.
Full textHashemi, H. M. "The regulation of spinal neurogenesis by PTPγ." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1400391/.
Full textHakim, Marziah. "Neurogenesis and neuroplasticity following olfactory fear conditioning." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/157474/1/Marziah_Hakim_Thesis.pdf.
Full textSturesson, André. "Exercise-induced adult hippocampal neurogenesis and the effect of exercise and adult hippocampal neurogenesis on spatial learning and memory." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-15918.
Full textMELIS, VALENTINA MARIA. "Effetto della separazione materna sulla plasticità dei neuroni nell’ippocampo delle mamme e della prole." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266624.
Full textCooper-Kuhn, Christiana Marie. "Regulation of neurogenesis in the adult mammalian brain." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968783007.
Full textDove, Hilary Livia. "Neurogenesis in the millipede Glomeris marginata (Myriapoda: Diplopoda)." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970030126.
Full textAndersson, Annika. "Studies on neurogenesis in the adult human brain." Thesis, Södertörn University College, School of Life Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-3646.
Full textMany studies on neurogenesis in adult dentate gyrus (DG) have been performed on rodents and other mammalian species, but only a few on adult human DG. This study is focusing on neurogenesis in adult human DG. To characterize the birth of cells in DG, the expression of the cell proliferation marker Ki67 was examined using immunohistochemistry. Ki67-positive labelling was indeed observed in the granular cell layer and the molecular layer of dentate gyrus and in the hilus of hippocampus, as well as in the subgranular zone (SGZ). The Ki67 positive nuclei could be divided into three groups, based on their morphology and position, suggesting that one of the groups represents neuronal precursors. Fewer Ki67 positive cells were seen in aged subjects and in subjects with an alcohol abuse. When comparing the Ki67 positive cells and the amount of blood vessels as determined by anti factor VIII, no systematic pattern could be discerned. To identify possible stem/progenitor cells in DG a co-labelling with nestin and glial fibrillary acid protein was carried out. Co-labelling was found in the SGZ, but most of the filaments were positive for just one of the two antibodies. Antibodies to detect immature/mature neurons were also used to investigate adult human neurogenesis in DG. The immature marker βIII-tubulin showed a weak expression. The other two immature markers (PSA-NCAM and DCX) used did not work, probably since they were not cross-reacting against human tissue. In summary, this study shows that new cells are continuously formed in the adult human hippocampus, but at a slower pace compared to the rat, and that some of these new cells may represent neuronal precursors.
Rhodes, Christopher. "Epigenetic Repression in the Context of Adult Neurogenesis." Thesis, The University of Texas at San Antonio, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10686193.
Full textNeural stem progenitor cells (NSPCs) in the mammalian brain contribute to life-long neurogenesis and brain health. Adult mammalian neurogenesis primarily occurs in the subventricular zone (SVZ) and the subgranular zone (SGZ) of the dentate gyrus. Epigenetic repression is a crucial regulator of cell fate specification during adult neurogenesis. How epigenetic repression impacts adult neurogenesis and how epigenetic dysregulation may impact neoplasia or tumorigenesis remains poorly understood. Examination of epigenetic regulation in the adult mammalian brain is complicated by the heterogeneous nature of neurogenic niches and by the highly orchestrated fate specification processes within neural stem progenitor cells involving myriad intrinsic and extrinsic factors. To overcome these challenges, we utilized a cross-species approach. To model histone modifications as they exist in vivo for epigenetic profiling, we isolated neural stem progenitor cells from the adult SVZ and SGZ of non-human primate baboon brains. To determine cellular and molecular changes within the adult SVZ and SGZ following loss of epigenetic repression, we utilized multiple mouse models, including conditional Ezh2 and Suv4-20h1 knockouts. To model the non-cell type specific effects common to small molecule screening and brain chemotherapeutic agents, induction of conditional knockout utilized a recombinant Cre protein. Finally, to model epigenetic mechanisms during SVZ-associated glioblastoma (GBM) tumorigenesis, we conducted comparative analysis between healthy NSPCs and GBM specimens from humans. The convergence of baboon, mouse and human models of adult neurogenesis revealed that epigenetic repression is a critical mechanism regulating proper neural cell fate and that epigenetic dysregulation may be a driver of GBM.
Ringuette, Randy. "The Role of Signaling Pathway Integration in Neurogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35108.
Full textCarlén, Marie. "Adult neurogenesis : from stem cell to functional neuron /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-367-1/.
Full textMelvin, Neal, and University of Lethbridge Faculty of Arts and Science. "Differential neurogenesis in the adult rat dentate gyrus." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008, 2008. http://hdl.handle.net/10133/727.
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Labban, Margaret. "The effects of perinatal hypoxia on hippocampal neurogenesis /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101594.
Full textNangla, Jyoti. "The study of neurogenesis in the rodent telencephalon." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325881.
Full textBandpey, Zhale. "Biphasic regulation of hippocampal neurogenesis by adrenal steroids." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608250.
Full textLeung, Wai-hin, and 梁瑋軒. "Neurogenesis in animal model of systemic lupus erythematosus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/209497.
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Abu-Elmagd, Muhammad. "cSox3 expression and neurogenesis in the epibranchial placodes." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367680.
Full textBiffar, Lucia. "Early neurogenesis in the flour beetle Tribolium castaneum." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8406.
Full textKrishnan, Vaishnavi M. "Characterisation of dephrin reverse signaling during Drosophila neurogenesis." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614714.
Full textOzen, Ilknur. "Neurogenin2, a molecular marker of postnatal hippocampal neurogenesis." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612424.
Full textPatel, Kaushal S. "Post-TBI Hippocampal Neurogenesis in Different TBI Models." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4134.
Full textChen, Yanshuang. "The Effect of Inorganic Nanostructured Materials on Neurogenesis." Master's thesis, Temple University Libraries, 2016. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/421454.
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Damage and/or loss of functional neurons can lead to detrimental cognitive and paralyzing effects in humans. Prime examples of such negative situations are well documented in patients with Parkinson's and Alzheimer's disease. In recent years, the utilization of neural stem cells and their derivation into neurons have been the focus of many research endeavors. The main reason for this is because neural stem cells are multi-potent and can differentiate into neurons, astrocytes, and oligodendrocytes. The research that will be detailed in this thesis involves the potential use of inorganic nanostructured materials to efficiently deliver bioactive molecules (i.e., retinoic acid, kinase inhibitors) to cells that can modulate the differentiation potential of certain cells into neurons. Specifically, PC12 (derived from rat pheochromocytoma) cells, as a neural model, was treated with select nanostructured materials with and without neuron inducers (molecules and ions) and the results were analyzed via biochemical assays and live-cell fluorescence microscopy. This thesis will include an in depth look into the cytocompatibility of the tested nanostructured materials that include silica nanoparticles, titanate nanotube microspheres, and carbon microparticles.
Temple University--Theses