Academic literature on the topic 'Neurodifferentiation'
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Journal articles on the topic "Neurodifferentiation"
Moreira, Natália Chermont dos Santos, Jéssica Ellen Barbosa de Freitas Lima, Talita Perez Cantuaria Chierrito, Ivone Carvalho, and Elza Tiemi Sakamoto-Hojo. "Novel Hybrid Acetylcholinesterase Inhibitors Induce Differentiation and Neuritogenesis in Neuronal Cells in vitro Through Activation of the AKT Pathway." Journal of Alzheimer's Disease 78, no. 1 (October 27, 2020): 353–70. http://dx.doi.org/10.3233/jad-200425.
Full textMaffezzini, Camilla, Javier Calvo-Garrido, Anna Wredenberg, and Christoph Freyer. "Metabolic regulation of neurodifferentiation in the adult brain." Cellular and Molecular Life Sciences 77, no. 13 (January 7, 2020): 2483–96. http://dx.doi.org/10.1007/s00018-019-03430-9.
Full textHuang, Min, Xiaoxiao Xiao, Guanxu Ji, and Qiang Wu. "Histone modifications in neurodifferentiation of embryonic stem cells." Heliyon 8, no. 1 (January 2022): e08664. http://dx.doi.org/10.1016/j.heliyon.2021.e08664.
Full textBelinsky, Glenn S., Carissa L. Sirois, Matthew T. Rich, Shaina M. Short, Anna R. Moore, Sarah E. Gilbert, and Srdjan D. Antic. "Dopamine Receptors in Human Embryonic Stem Cell Neurodifferentiation." Stem Cells and Development 22, no. 10 (May 15, 2013): 1522–40. http://dx.doi.org/10.1089/scd.2012.0150.
Full textQutub, Amina Ann, Erin Pollet, Byron Long, Arun Mahadevan, and George Britton. "DIGITIZING BRAIN HEALTH: FROM NEURODIFFERENTIATION TO DAILY ACTIVITIES." Alzheimer's & Dementia 15, no. 7 (July 2019): P161. http://dx.doi.org/10.1016/j.jalz.2019.06.4330.
Full textSlotkin, Theodore A., and Frederic J. Seidler. "Benzo[a]pyrene impairs neurodifferentiation in PC12 cells." Brain Research Bulletin 80, no. 1-2 (August 2009): 17–21. http://dx.doi.org/10.1016/j.brainresbull.2009.06.003.
Full textBlando, Santino, Ivana Raffaele, Luigi Chiricosta, Andrea Valeri, Agnese Gugliandolo, Serena Silvestro, Federica Pollastro, and Emanuela Mazzon. "Cannabidiol Promotes Neuronal Differentiation Using Akt and Erk Pathways Triggered by Cb1 Signaling." Molecules 27, no. 17 (September 1, 2022): 5644. http://dx.doi.org/10.3390/molecules27175644.
Full textParfejevs, V., M. Gavare, L. Cappiello, M. Grube, R. Muceniece, and U. Riekstina. "Evaluation of Biochemical Changes in Skin-Derived Mesenchymal Stem Cells duringIn VitroNeurodifferentiation by FT-IR Analysis." Spectroscopy: An International Journal 27 (2012): 315–20. http://dx.doi.org/10.1155/2012/286542.
Full textHsu, Wei-Hsiang, Nai-Kuei Huang, Young-Ji Shiao, Chung-Kuang Lu, Yen-Ming Chao, Yi-Jeng Huang, Chih-Hsin Yeh, and Yun-Lian Lin. "Gastrodiae rhizoma attenuates brain aging via promoting neuritogenesis and neurodifferentiation." Phytomedicine 87 (July 2021): 153576. http://dx.doi.org/10.1016/j.phymed.2021.153576.
Full textLai, Bin, Xiao Ou Mao, Lin Xie, Kunlin Jin, and David A. Greenberg. "Electrophysiological neurodifferentiation of subventricular zone-derived precursor cells following stroke." Neuroscience Letters 442, no. 3 (September 2008): 305–8. http://dx.doi.org/10.1016/j.neulet.2008.07.032.
Full textDissertations / Theses on the topic "Neurodifferentiation"
Maggioni, M. "GM1-MEDIATED NEURODIFFERENTIATION IS PROMOTED BY OLIGOGM1-TRKA INTERACTION." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/543684.
Full textWakhloo, Debia Rajnath [Verfasser]. "Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage / Debia Rajnath Wakhloo." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1221802267/34.
Full textDI, BIASE ERIKA. "GM1 OLIGOSACCHARIDE ACCOUNTS FOR GM1 ROLE IN ENHANCING NEURONAL DEVELOPMENT ACTING ON TRKA-MAPK PATHWAY." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/692335.
Full textThe GM1 ganglioside is a mono-sialylated glycosphingolipid present in the outer layer of the cell plasma membrane and abundant in neurons. Numerous in vitro and in vivo studies highlight the role of GM1 not only as a structural component but also as a functional regulator. Indeed, GM1 enrichment in membrane microdomains promotes neuronal differentiation and protection, and the GM1 content is essential for neuronal survival and maintenance. Despite many lines of evidence on the GM1-mediated neuronotrophic effects, our knowledge on the underlying mechanism of action is scant. Recently, the oligosaccharide chain of GM1 (oligoGM1) has been identified as responsible for the neuritogenic properties of the GM1 ganglioside in neuroblastoma cells. The oligoGM1-mediated effects depend on its binding to the NGF specific receptor TrkA, thus resulting in the TrkA-MAPK pathway activation. In this context, my PhD work aimed to confirm the role of the oligoGM1, as the bioactive portion of the entire GM1 ganglioside, capable of enhancing the differentiation and maturation processes of mouse cerebellar granule neurons. First, we performed time course morphological analyses on mouse primary neurons plated in the presence or absence of exogenously administered gangliosides GM1 or GD1a (direct GM1 catabolic precursor). We found that both gangliosides increased neuron clustering and arborization, however only oligoGM1 and not oligoGD1a induced the same effects in prompting neuron migration. This result suggests the importance of the specific GM1 saccharide structure in mediating neuronotrophic effects. Then we characterized biochemically the oligoGM1-mediated effect in mouse primary neurons, and we observed a higher phosphorylation rate of FAK and Src proteins which are the intracellular key regulators of neuronal motility. Moreover, in the presence of oligoGM1 cerebellar granule neurons showed increased level of specific neuronal markers (e.g., β3-Tubulin, Tau, Neuroglycan C, Synapsin), suggesting an advanced stage of maturation compared to controls. In addition, we found that the oligoGM1 accelerates the expression of the typical ganglioside pattern of mature neurons which is characterized by high levels of complex gangliosides (i.e., GM1, GD1a, GD1b, and GT1b) and low level of the simplest one, the GM3 ganglioside. To study the mechanism of action of the oligoGM1, we used its tritium labeled derivative and we found that the oligoGM1 interacts with the cell surface without entering the cells. This finding suggests the presence of a biological target at the neuronal plasma membrane. Interestingly, we observed the TrkA-MAP kinase pathway activation as an early event underlying oligoGM1 effects in neurons. Our data reveal that the effects of GM1 ganglioside on neuronal differentiation and maturation are mediated by its oligosaccharide portion. Indeed, oligoGM1 interacts with the cell surface, thus triggering the activation of intracellular biochemical pathways that are responsible for neuronal migration, dendrites emission and axon growth. Overall, our results point out the importance of oligoGM1 as a new promising neurotrophic player.
LUNGHI, GIULIA. "GM1 OLIGOSACCHARIDE MODULATION OF CALCIUM SIGNALLING IN NEURONAL FUNCTIONS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/792078.
Full textWakhloo, Debia Rajnath. "Erythropoietin as a driver of neurodifferentiation, neuroplasticity and cognition – A continuum view of the neuronal lineage." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-12C2-B.
Full textTu, Yuan-Yu, and 杜元佑. "Neurodifferentiation potentials of stem cells from human exfoliated deciduous teeth and stem cells from apical papilla." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/45237653190149495141.
Full text國立臺灣大學
臨床牙醫學研究所
100
Aim:Both Stem cells from human exfoliated deciduous teeth (SHED) and Stem cells from apical papilla (SCAP) are multipotent stem cells. After neural induction, these two kinds of cells could be differentiated into neuron like cells. We hypothesized that SHED and SCAP have the same neurodifferentiation potentials. The purpose of this study is to compare the differences of neurodifferentiation potentials of SHED and SCAP. Materials and Methods:We cultivated SHED and SCAP in neural induction medium for 0 day, 1 day ,3 days, 7 days , 14 days and 21 days and analyzed cell morphology, cell proliferation, gene expression patterns(RT-PCR) and immunofluorescence before and after differentiation. Results:After 3 days cultivation in neural induction medium, the morphology of SHED and SCAP were changed to neuron like cells. We found that cell proliferation of SHED and SCAP were reduced. After 7 days cultivation in neural induction medium, gene expression patterns (RT-PCR) and Immunofluorescence analysis of the expression Neurofilament demonstrated that both SHED and SCAP were successfully differentiate into neuron cells. However, the Neurofilament gene expression of inducted SCAP was much upregulated then that of inducted SHED. This result indicated that the neurodifferentiation potential of SCAP is higher than that of SHED. Conclusion :Although both SHED and SCAP have potentials for neurodifferentiation but neurodifferentiation potential of SCAP is much better than that of SHED. We can expect that by using SCAP for neurogenesis would get better results.
Book chapters on the topic "Neurodifferentiation"
Limaye, Pallavi V., Michele L. McGovern, Mandakini B. Singh, Katerina D. Oikonomou, Glenn S. Belinsky, Erika Pedrosa, Herbert M. Lachman, and Srdjan D. Antic. "Temporal Dynamics of Spontaneous Ca2+ Transients, ERBB4, vGLUT1, GAD1, Connexin, and Pannexin Genes in Early Stages of Human Stem Cell Neurodifferentiation." In Pluripotent Stem Cells - From the Bench to the Clinic. InTech, 2016. http://dx.doi.org/10.5772/62769.
Full textConference papers on the topic "Neurodifferentiation"
Kirchinger, M., L. Bieler, S. Couillard-Despres, H. Riepl, and C. Urmann. "Characterization of a Neurodifferentiation Inducing Flavonoid/Cyclodextrin Inclusion Complex." In GA 2017 – Book of Abstracts. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1608380.
Full textRitter, S., C. Urmann, L. Bieler, S. Couillard-Després, and H. Riepl. "Study of neurodifferentiation potential of different extracts of Bacopa monnieri." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400091.
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