Dissertations / Theses on the topic 'Neurite regeneration'
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Tan, Hiang Khoon. "Investigating the effects of TIMPs on excitotoxicity and neurite regeneration." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247230.
Full textWitheford, Richter Miranda. "Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/963.
Full textTam, Kin-wai, and 譚健偉. "Study of chondroitin sulphate abc lyases and their use in combination for promotion of neurite growth." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43571955.
Full textChu, Gordon Kwok Tung. "The role of calcium in neuronal death and regeneration after neurite transection in a cell culture model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0001/MQ46107.pdf.
Full textWernicke, Catrin V. [Verfasser]. "Degeneration, Protektion und Regeneration dopaminerger Neurone / Catrin V. Wernicke." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1025239318/34.
Full textGhaffari, Mithra. ""Glial Islands" promote survival and regeneration of neurites from chick embryo retinal neurons." CSUSB ScholarWorks, 1997. https://scholarworks.lib.csusb.edu/etd-project/1458.
Full textFayaz, Imran. "Modeling axonal injury in vitro, injury, regeneration, and calcium dynamics following acute neuritic trauma." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq29281.pdf.
Full textDinis, Tony Mickael. "Prothèse nerveuse artificielle à partir de fibroïne de soie pour la réparation et la régénération de nerfs périphériques." Thesis, Compiègne, 2014. http://www.theses.fr/2014COMP2152/document.
Full textPeripheral nerve injury causes sensory and/or motor functions deficits. Despite technological advances over the past 25 years, a complete recovery from these injuries remains unsatisfactory today. The autograft still considered the "gold standard" in clinical practice. This is the only technique able to offer complete functional recovery. However, the occurrence of postoperative complications in autologous nerve and the limited amount of available nerves lead to develop alternatives strategy.In this context, development of nerve graft substitutes becomes by far a clinical necessity. Despite research efforts, these artificial prostheses design based on biomaterial doesn’t allow nerve regeneration as found in autograft nerve procedures. The biomaterial used must have the physical and chemical properties similar to that of the native nerve. Silk, well known for its unique mechanical properties, proposes a good alternative to develop these prostheses. Indeed, the silk protein is commonly used in the biomedical field and regenerative medicine. This protein biocompatibility may be improved through chemical modifications to promote adhesion and cell growth by the incorporation of growth factors or other molecules of interest. Therefore, this thesis proposes to develop a new type of functionalized silk biomaterial based on two growth factors : Nerve Growth Factor (NGF) and Ciliary NeuroTrophic Factor (CNTF). Given the complex architecture that consists of nerve structure, a matrix which is able to support and manage the outgrowth of tissue becomes essential. We demonstrate the power of these aligned nanofibers (produced by electrospinning) to guide and manage tissue regeneration from different organ explants culture. Aligned silk nanofibers, were biocompatible and bio-activated by adding NGF involved for nerve regeneration. This matrix has been created with a concentration gradient of NGF to guide neuritis outgrowth in only one direction. The presence of this gradient demonstrated a better axonal growth in one direction versus the uniform concentration conditions. Nerve cells consist essentially of two cell populations which are neurons and Schwann cells. To optimize the culture and growth of these two populations, in addition to NGF, we incorporated CNTF to produce bifunctionalized nanofibers. These biofunctionalised nanofibers led to a length 3 times larger on contact with neurites. The glial cells growth, alignment and migration were stimulated by CNTF. Thus, we produced bi-functionalized nerve guidance conduits for rat implantation. The physico-chemical analyzes demonstrate the biomimetic of our guide tubes. Early studies of locomotion and observing histological sections of rat sciatic nerve, following the implementation of our conduits gave very promising results.These studies demonstrate the relevance of our nervous guides’ silk-based developed as an effective alternative to nerve autograft performed in the clinic
Jerregård, Helena. "Factors influencing nerve growth in situ and in vitro /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med693s.pdf.
Full textMille-Hamard, Laurence. "Transplantation de ganglions rachidiens fœtaux et adultes dans la moelle épinière et dans le nerf péronier du rat adulte : survie, expression phénotypique et capacité de repousse axonale des neurones sensoriels primaires qui y sont contenus." Paris 5, 1997. http://www.theses.fr/1997PA05S031.
Full textAngonin, Diane. "Lineage-specific manipulation of subventricular zone germinal activity for neonatal cortical repair." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1175/document.
Full textPerinatal hypoxia leads to degeneration and delayed maturation of oligodendrocytes and cortical glutamatergic neurons. My PhD project consists in assessing the contribution of neural stem cells (NSCs) of the dorsal subventricular zone (dSVZ, i.e. the largest germinal zone of the postnatal brain) to the spontaneous regenerative attempt observed following such injury as well as its amenability to pharmacological manipulation.The results I have obtained highlight a dynamic and lineage-specific response of NSCs of the dSVZ to hypoxia that results in de novo oligodendrogenesis and cortical neurogenesis. Newborn cortical neurons express appropriate cortical layer markers, supporting their appropriate specification. A pharmacogenomics analysis allowed us to identify small molecules boosting specificly dSVZ NSCs. Pharmacological activation of Wnt/ß-catenin signalling by intranasal GSK3ß inhibitor administration during the recovery period following hypoxia indeed potentiates dorsal SVZ participation to post-hypoxia repair. Gsk3b inhibitor CHIR99021 seems to promote survival of cortical neurons from the dSVZ produced in response to hypoxia. More interestingly, CHIR99021 promotes oligodendrocyte maturation and long term integration in the cortex as well as a long term increased activity of dSVZ NSCs.Altogether, my results highlighted a dynamic and lineage-specific response of dorsal NSCs cells to hypoxia and identify the early postnatal dorsal SVZ as a malleable source of stem cells for cortical repair following trauma that occur early in life. CHIR99021 (a Gsk3b inhibitor) intranasal administration promotes this cortical cellular repair with a long term activation of dSVZ NSCs which increased their production of oligodendrocytes migrating to the cortex and a short term improvement of their maturation, and might allow the integration of cortical neurons they produce
Ng, JMJ. "Elucidating the roles of aurora B kinase in neurons." Thesis, 2012. https://eprints.utas.edu.au/15014/3/whole-ng-thesis-incl-pub-mat.pdf.
Full textBoato, Francesco [Verfasser]. "Hypothermia and C3 peptide promote neurite outgrowth and regeneration after traumatic CNS injury / von Francesco Boato." 2010. http://d-nb.info/1010578448/34.
Full textSchense, Jason Charles. "Enzymatic incorporation of bidomain peptides into fibrin matrices for directed enhancement of three-dimensional in vitro neurite outgrowth and in vivo nerve regeneration." Thesis, 1999. https://thesis.library.caltech.edu/742/1/Schense_jc_1999.pdf.
Full textLau, Billy You Bun. "Molecular mechanisms of neural plasticity after spinal cord injury in the lamprey central nervous system." 2012. http://hdl.handle.net/2152/22128.
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Bhattarai, Prabesh. "Molecular mechanisms of neural stem cell plasticity and neuro-regeneration in an Alzheimer’s-like neurodegeneration model of adult zebrafish." 2020. https://tud.qucosa.de/id/qucosa%3A73249.
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