Dissertations / Theses on the topic 'Neural development'
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De, Sousa C. A. Ferreira. "Vertebrate somite development and neural patterning." Thesis, Cranfield University, 2013. http://dspace.lib.cranfield.ac.uk/handle/1826/10567.
Full textMayer, Eric. "Development of intrastriatal neural transplantation techniques." Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282924.
Full textFourla, Danai-Dionysia. "Retinoid signalling in Xenopus neural development." Thesis, University of Portsmouth, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439189.
Full textTownsend, Joseph Paul. "Artificial development of neural-symbolic networks." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/15162.
Full textCottens, Pablo Eduardo Pereira de Araujo. "Development of an artificial neural network architecture using programmable logic." Universidade do Vale do Rio dos Sinos, 2016. http://www.repositorio.jesuita.org.br/handle/UNISINOS/5411.
Full textMade available in DSpace on 2016-06-29T14:42:16Z (GMT). No. of bitstreams: 1 Pablo Eduardo Pereira de Araujo Cottens_.pdf: 1315690 bytes, checksum: 78ac4ce471c2b51e826c7523a01711bd (MD5) Previous issue date: 2016-03-07
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Normalmente Redes Neurais Artificiais (RNAs) necessitam estações de trabalho para o seu processamento, por causa da complexidade do sistema. Este tipo de arquitetura de processamento requer que instrumentos de campo estejam localizados na vizinhança da estação de trabalho, caso exista a necessidade de processamento em tempo real, ou que o dispositivo de campo possua como única tarefa a de coleta de dados para processamento futuro. Este projeto visa criar uma arquitetura em lógica programável para um neurônio genérico, no qual as RNAs podem fazer uso da natureza paralela de FPGAs para executar a aplicação de forma rápida. Este trabalho mostra que a utilização de lógica programável para a implementação de RNAs de baixa resolução de bits é viável e as redes neurais, devido à natureza paralelizável, se beneficiam pela implementação em hardware, podendo obter resultados de forma muito rápida.
Currently, modern Artificial Neural Networks (ANN), according to their complexity, require a workstation for processing all their input data. This type of processing architecture requires that the field device is located somewhere in the vicintity of a workstation, in case real-time processing is required, or that the field device at hand will have the sole task of collecting data for future processing, when field data is required. This project creates a generic neuron architecture in programmabl logic, where Artifical Neural Networks can use the parallel nature of FPGAs to execute applications in a fast manner, albeit not using the same resolution for its otputs. This work shows that the utilization of programmable logic for the implementation of low bit resolution ANNs is not only viable, but the neural network, due to its parallel nature, benefits greatly from the hardware implementation, giving fast and accurate results.
Waldhuber, Markus. "Neural stem cells in development and cancer." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-92214.
Full textSubbarao, Tara. "Effects of nicotine on embryological neural development." Connect to resource, 2007. http://hdl.handle.net/1811/24616.
Full textTitle from first page of PDF file. Document formatted into pages: contains 18 p.; also includes graphics. Includes bibliographical references. Available online via Ohio State University's Knowledge Bank.
Chuong, Amy (Amy S. ). "Development of next-generation optical neural silencers." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/69521.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (p. 65-74).
The ability to rapidly and safely silence the electrical activity of individual neurons or neuron populations is invaluable in the study of brain circuit mapping. The expression of light-driven ion channels and pumps allows these pathways to be observed, mapped and controlled with millisecond timescale resolution. We here show that it is possible to mediate the powerful multiple-color silencing of neural activity through the heterologous expression of light-driven outward proton pumps and inward chloride pumps. We characterized a number of novel opsins through an exploration of ecological and genomic diversity, and further boosted opsin function and trafficking through the appendage of signal sequences. The green-light drivable archaerhodopsin-3 (Arch) from Halorubrum sodomense and the yellow-light drivable archaerhodopsin from Halorubrum strain TP009 (ArchT) are able to mediate complete neuron silencing in the in vivo awake mouse brain, and the blue-light drivable proton pump from Leptosphaeria maculans (Mac) opens up the potential for the multiple-color control of independent neuron populations. Finally, the principles outlined here can be extrapolated to the larger context of synthetic physiology.
by Amy Chuong.
S.M.
Canales, Andrés. "Development of neural probes using thermal drawing." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/111316.
Full textCataloged from PDF version of thesis.
Includes bibliographical references (pages 127-147).
The treatment of neurodegenerative and neurological conditions relies on better understanding the system that they afflict. However, the tools currently available to probe neural circuits are often limited to use in short-term studies primarily due to poor of biocompatibility. To address this challenge, flexible, minimally invasive neural probes were fabricated using a thermal drawing process, with polymers serving as their main structural constituent. Through the use of different polymers, probes containing arrays of tin electrodes as small as 5 [mu]m were fabricated, as were probes combining capabilities for electrical recording, optical stimulation, and drug delivery. A technique was developed to combine functionalities of these devices into a single probe to study the effect of optical stimulation with different waveforms on the brain activity. To break the longitudinal symmetry inherent to probes fabricated using the thermal drawing process, and to allow the incorporation of functionalities along the probe length, a method to combine thermal drawing with a method commonly used to fabricate neural probes, photolithography, was developed, along with the selection of the polymer that would allow consecutive processing using these two techniques. All of the fabricated probes were characterized and tested in vivo by implantation into mice and assessing their functionality. High signal-to-noise ratio (13±6) recordings were obtained using multielectrode arrays. Recordings of neural activity during simultaneous optical stimulation and drug delivery were performed with multifunctional probes. Hybrid probes combining metal electrodes with a polymer waveguide were used to study the response of large groups of neurons to different forms of optical stimuli. Most importantly, the biocompatibility of these probes was assessed over a 3 month period and compared favorably to that of steel microwires of similar size.
by Andrés Canales.
Ph. D.
Biswas, Sayantanee. "Role of Protocadherins in Zebrafish Neural Development." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354720718.
Full textWestermann, Gert. "Constructivist neural network models of cognitive development." Thesis, University of Edinburgh, 2000. http://hdl.handle.net/1842/22733.
Full textMurtaza, Mariyam. "The role of Crumbs2 in neural development." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/2221/.
Full textElms, Paul. "The role of the Zic genes in mouse neural crest development." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:89d42621-6028-469f-a630-298ece9980ff.
Full textGacem, Nadjet. "Rôle d'ADAR1 dans le développement de la crête neurale." Thesis, Paris Est, 2019. http://www.theses.fr/2019PESC0016.
Full textNeural crest cells are a population of multipotent precursor cells that emerge at the borders of the neural tube, migrate extensively throughout the embryo, and differentiate into a variety of cell types including the skin pigment cells (melanocytes), glia of the peripheral nervous system (including Schwann cells that form myelin) and the neurons and glia of the enteric nervous system. Each steps of the development of these cells is under the control of external stimuli and tightly regulated transcription factors that form a complex network. The role of epigenetic and post-transcriptional modifications was also highlighted, but their contributions to related disorders are still poorly described. The aim of my PhD project was to investigate the role of one of the most common post-transcriptional modification: the Adenosine to Inosine (A to I) RNA editing, in normal and pathologic NC development. Here, we report that adenosine deaminase acting on RNA (ADAR1), responsible for A to I editing of RNA, is required for regulating the development of three neural-crest derivatives: melanocytes, Schwann cells and enteric nervous system. Neural-crest specific conditional invalidation of Adar1 in mice led to global depigmentation and absence of myelin from peripheral nerves, resulting from alterations in melanocyte survival and late differentiation of Schwann cells respectively. Defects of enteric glia is also evidenced. These defects were preceded by upregulation of an innate immune inflammatory response. Simultaneous extinction of MDA5, a key sensor for the detection of unedited RNA, rescued the pigmentation and myelin defects of Adar1 mutants, suggesting that ADAR1 safeguards a subset of neural-crest derivatives from aberrant MDA5-mediated interferon production. We thus extend the landscape of ADAR1 function to the fields of neural-crest development and disease
Moase, Connie E. (Connie Evelyn). "Cell interactions in abnormal neural tube and neural crest cell development of splotch mice." Thesis, McGill University, 1991. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=70336.
Full textRingstedt, Thomas. "Neurotrophins during development : overexpression in neural stem cells /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980605ring.
Full textAgarwal, Pooja. "Transcriptional control of neural crest development by MEF2C." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390029.
Full textVais, Ricardo Silva dos Santos. "The Role of Microtubule nucleation during neural development." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668349.
Full textEl complejo de anillo gamma-‐tubulina (γTuRC) es necesario para generar microtúbulos de manera eficiente en un proceso conocido como nucleación de microtúbulos. En células mitóticas, la nucleación a partir del γTuRC tiene lugar en el centrosoma, en regiones próximas a los cromosomas y en la superficie de microtúbulos previamente formados, en un proceso que requiere adicionalmente la presencia del complejo de augmina. A pesar de que en neuronas el centrosoma pierde su capacidad nucleadora de microtúbulos, el γTuRC aún puede inducir la nucleación en otros lugares. Sin embargo, aún se desconoce cómo se regula el γTuRC en estas células y si, aparte del centrosoma, existen otros lugares que puedan funcionar como centros organizadores de microtúbulos. El objetivo de esta tesis doctoral es entender cómo la nucleación de microtúbulos dependiente de augmina y del γTuRC contribuyen al desarrollo cerebral y cómo se regula la nucleación de microtúbulos durante este proceso. En esta tesis hemos demostrado que el complejo de augmina es necesario para el desarrollo de axones y dendritas in vitro. En el axón, augmina garantiza que los microtúbulos se nucleen en una orientación adecuada, asegurando una polaridad microtubular uniforme a lo largo del axón. Por otro lado, la ausencia de augmina causa una disminución general en la densidad de microtúbulos de las dendritas, sin afectar a su polaridad. Sorprendentemente, a pesar de nuestros descubrimientos, otros grupos han analizado la función de augmina in vivo (en moscas y pez cebra) sin encontrar ningún defecto significativo. Curiosamente, hemos observado que, en ratones knockout condicionales en los que la subunidad Haus6 de augmina ha sido delecionada de progenitores neuronales, el desarrollo cerebral se interrumpe antes del decimotercer día del desarrollo embrionario. Adicionalmente, esta condición resulta letal para los animales, que mueren durante el nacimiento. Se ha encontrado que las causas de estos dramáticos defectos cerebrales son problemas en mitosis y una muerte masiva de neuroprogenitores. Estos resultados indican que existen diferencias en el requerimiento de augmina entre diferentes especies. En la última parte de esta tesis identificamos KIF2A y CEP170 como interactores del γTuRC en neuronas corticales de ratones cultivadas in vitro. También demostramos que, en concordancia con datos publicados sobre KIF2A, CEP170 parece inhibir el crecimiento de ramificaciones laterales en axones. Nuestra hipótesis es que tanto KIF2A como CEP170 podrían actuar como reguladores negativos de la nucleación de microtúbulos dependiente de γTuRC. En conclusión, estos resultados demuestran que la nucleación dependiente de augmina es un proceso esencial en el desarrollo cerebral humano, y proporcionan una primera visión de cómo interactores del γTuRC pueden regular la nucleación de microtúbulos en neuronas.
Coles, Brenda L. K. "Neural changes in forelimb cortex and behavioural development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ38447.pdf.
Full textGarriock, Robert John. "Wnt11-Signaling Regulates Cardiac and Neural Crest Development." Diss., Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1655%5F1%5Fm.pdf&type=application/pdf.
Full textColes, Brenda Louise Kay, and University of Lethbridge Faculty of Arts and Science. "Neural changes in forelimb cortex and behavioural development." Thesis, Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 1996, 1996. http://hdl.handle.net/10133/85.
Full textx, 132 leaves : ill. ; 28 cm.
Sirois, Sylvain. "A neural network perspective on learning and development /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36836.
Full textThe second manuscript reports simulations of additional discrimination shift tasks. These are the intradimensional and extradimensional shift tasks, in which novel stimuli are introduced in the relearning phase. Preschoolers and adults exhibit the same pattern of behavior in this variant of shift learning. Simulation results show that the spontaneous overtraining hypothesis captures this effect.
The third chapter reports an empirical validation of the shift learning model. If the shift learning performance of adults is a consequence of more extensive processing, it follows that adults in whom such processing is prevented should perform as preschoolers. Sixty adults took part in a shift learning experiment with a Brown-Peterson task as a cognitive load. Results mirror those observed with preschoolers. As a control, 40 adults performed the shift learning experiment without the cognitive load. These results replicate the typical adult performance. Overall, these experiments lend additional support to the model developed in Manuscript 1.
The final manuscript is a theoretical discussion of the relationship between learning and development. Two classes of neural networks are discussed, and their underlying assumptions about learning and development are highlighted. These are static architecture and generative architecture networks. It is argued that only generative algorithms, such as used in the shift learning simulations, qualify as developmental models. Both classes of networks are further contrasted with respect to innateness. The comparison suggests that only generative networks can acquire genuinely new representations. The manuscript proposes a novel formulation of Piaget's constructivism from the generative neural network perspective.
Sales, Nicholas John. "Aspects of lexical development in artificial neural networks." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317984.
Full textEngland, S. J. "Morphogenetic analysis of neural development in the zebrafish." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598850.
Full textLiu, Zhe. "The role of Robo in vertebrate neural development." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402169.
Full textWard, Nicole J. "miRNAs and their role in neural crest development." Thesis, University of East Anglia, 2017. https://ueaeprints.uea.ac.uk/65119/.
Full textHatch, Victoria. "Transcriptional elongation is important for neural crest development." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/48100/.
Full textLin, Hsuan-Hwai. "Investigating the role of Neuronatin in neural development." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/investigating-the-role-of-neuronatin-in-neural-development(c7fad85a-bdaf-4d98-bc6b-8b465c8675bb).html.
Full textBydon, Mohamad. "Molecular genetic approaches to diseases of neural development." [New Haven, Conn. : s.n.], 2008. http://ymtdl.med.yale.edu/theses/available/etd-11212008-112418/.
Full textEusebi, Silvia. "Creatine supplementation and neural plasticity in CNS development." Doctoral thesis, Urbino, 2018. http://hdl.handle.net/11576/2663607.
Full textUnal, Eroglu Arife. "REGULATION OF NEURAL CREST DEVELOPMENT REQUIRES FUNCTIONAL INTERACTIONS BETWEEN HDAC1, TFAP2A AND FOXD3." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1357141637.
Full textOsório, da Silva Liliana Alexandra. "Development of the caudal-most neural crest in the chick embryo." Paris 6, 2008. http://www.theses.fr/2008PA066208.
Full textЗубенко, О. В., Л. М. Семенова, O. V. Zubenko, and L. M. Semenova. "Artificial Neural Networks and Their Current Level of Development." Thesis, Міжнародний гуманітарний університет; Південний регіональний центр Національної академії правових наук України, 2018. http://ir.lib.vntu.edu.ua//handle/123456789/24113.
Full textВ роботі розглянуто нейронні мережі як один з провідних сучасних напрямків розвитку інформаційних технологій. Представлено загальну концепцію нейронної мережі, основні різновиди таких мереж та їх сучасний рівень розвитку.
Enjin, Anders. "Neural Control of Movement : Motor Neuron Subtypes, Proprioception and Recurrent Inhibition." Doctoral thesis, Uppsala universitet, Genetisk utvecklingsbiologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-147361.
Full textMacDonald, Jessica. "Methyl-CpG-Binding domain proteins and histone deacetylases in the stage-specific differentiation of olfactory receptor neurons." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/248.
Full textHaj, Fawaz Girgis. "CRYP#alpha# expression and ligand binding properties in the developing chick nervous system." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298627.
Full textLee, Yuk Wa. "Characterization of Mab21l2 in neural development of vertebrate model /." View abstract or full-text, 2005. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202005%20LEEY.
Full textKadomatsu, Kenji. "The midkine family in cancer, inflammation and neural development." Nagoya University School of Medicine, 2005. http://hdl.handle.net/2237/5407.
Full textIshikawa, Yuji, Takako Yasuda, Keiko Maeda, Atsuko Matsumoto, and Kouichi Maruyama. "Apoptosis in neural tube during normal development of medaka." Laboratory of Freshwater Fish Stocks Bioscience and Biotechnology Center Nagoya University, 2007. http://hdl.handle.net/2237/13834.
Full textJohansson, Amica. "Temporal regulation of neural stem cells during cortex development." Thesis, KTH, Skolan för bioteknologi (BIO), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-215288.
Full textMilne, Charlotte Anne. "Analysis of neural development using ligand-trap transgenic lines." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444843/.
Full textHartley, K. "The role of BMPs in Xenopus anterior neural development." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603812.
Full textWang, Qing. "Improving the cost model development process using neural networks." Thesis, De Montfort University, 2000. http://hdl.handle.net/2086/4196.
Full textKorsoni, Eleni. "The development and neural basis of visual re-entrance." Thesis, Birkbeck (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417061.
Full textHeath, Lindsay Anne. "Heterogeneity in neural crest development detected by monoclonal antibodies." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293618.
Full textBernstein, Jacob (Jacob Gold). "Development of extracellular electrophysiology methods for scalable neural recording." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107581.
Full textCataloged from PDF version of thesis.
Includes bibliographical references.
In order to map the dynamics of neural circuits in mammalian brains, there is a need for tools that can record activity over large volumes of tissue and correctly attribute the recorded signals to the individual neurons that generated them. High-resolution neural activity maps will be critical for the discovery of new principles of neural coding and neural computation, and to test computational models of neural circuits. Extracellular electrophysiology is a neural recording method that has been developed to record from large populations of neurons, but well-known problems with signal attribution pose an existential threat to the viability of further system scaling, as analyses of network function become more sensitive to errors in attribution. A key insight is that blind-source separation algorithms such as Independent Component Analysis may ameliorate problems with signal attribution. These algorithms require recording signals at much finer spatial resolutions than existing probes have accomplished, which places demands on recording system bandwidth. We present several advances to technologies in neural recording systems, and a complete neural recording system designed to investigate the challenges of scaling electrophysiology to whole brain recording. We have developed close-packed microelectrode arrays with the highest density of recording sites yet achieved, for which we built our own data acquisition hardware, developed with a computational architecture specifically designed to scale to over several orders of magnitude. We also present results from validation experiments using colocalized patch clamp recording to obtain ground-truth activity data. This dataset provides immediate insight into the nature of electrophysiological signals and the interpretation of data collected from any electrophysiology recording system. This data is also essential in order to optimize probe development and data analysis algorithms which will one day enable whole-brain activity mapping.
by Jacob G. Bernstein.
Ph. D.
Hemmati, Houman David Rothenberg Ellen V. "Neural stem and progenitor cells in cancer and development /." Diss., Pasadena, Calif. : Caltech, 2006. http://resolver.caltech.edu/CaltechETD:etd-05232006-140457.
Full textGessaroli, Erica <1983>. "Development, degeneration and neural network of the bodily self." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6342/1/Gessaroli_Erica_tesi.pdf.
Full textGessaroli, Erica <1983>. "Development, degeneration and neural network of the bodily self." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6342/.
Full textMandal, Rakesh Kumar. "Development of Neural Network techniques to recognize handwritten characters." Thesis, University of North Bengal, 2015. http://ir.nbu.ac.in/handle/123456789/1790.
Full text