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Dissertations / Theses on the topic 'Neural crest cells'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

De, Mattos Coelho Aguiar Juliana. "Mesenchymal potentials of the trunk neural crest cells." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00982495.

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The neural crest (NC) derives from the dorsal borders of the vertebrate neural tube. During development, the NC cells migrate and contribute to the formation of different tissues and organs. Along the anteroposterior axis, the NC gives rise to neurons and glia of the peripheral nervous system and to melanocytes. Furthermore, the cephalic NC yields mesenchymal tissues, which form all facial cartilages and bones, the large part of skull, facial dermis, fat cells and smooth muscle cells in the head. In the trunk of amniotes Vertebrates, these tissues are derived from the mesoderm, not from the NC

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2

Allardyce, Joanna Marie. "Analysis of Wt1 expression in neural crest cells." Thesis, University of Liverpool, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569213.

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The neural crest is a transient collection of cell, termed neural crest cells (NCCs), which develop during neurulation at the outer extremities of the neural folds between surface ectoderm and the developing neural tube. NCCs del aminate from the crest and migrate throughout the developing embryo and differentiate into many cell types such as melanocytes, peripheral neurons, osteocytes, muscle cells and enteric neurons and glia. With the use of a lineage tracing system (Wtl-Cre X Rosa26R mouse line) it was previously found that cells derived from Wtl-expressing cells have contributed to the po

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3

Ngamjariyawat, Anongnad. "The beneficial Effects of Neural Crest Stem Cells on Pancreatic β–cells". Doctoral thesis, Uppsala universitet, Institutionen för neurovetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233157.

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Patients with type-1 diabetes lose their β-cells after autoimmune attack. Islet transplantation is a co-option for curing this disease, but survival of transplanted islets is poor. Thus, methods to enhance β-cell viability and function as well as methods to expand β-cell mass are required. The work presented in this thesis aimed to study the roles of neural crest stem cells or their derivatives in supporting β-cell proliferation, function, and survival. In co-culture when mouse boundary cap neural crest stem cells (bNCSCs) and pancreatic islets were in direct contact, differentiating bNCSCs st

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4

Ballard, Victoria. "The contribution of extracardiac cells to the developing heart." Thesis, University of Surrey, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250728.

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5

Okeke, Chukwuebuka. "Role of Nr2f Nuclear Receptors in Controlling Early Neural Crest and Ectomesenchyme Gene Regulation." University of Cincinnati / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1627660719070357.

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6

Johnston, D. A. "The avian neural crest : behaviour and long-term survival in culture." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376464.

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7

Nekooie, Marnany Nioosha. "The Intersection of Metabolism and Neural Crest Cell Development." Electronic Thesis or Diss., Paris 12, 2022. http://www.theses.fr/2022PA120066.

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Le métabolisme en tant que clé de voûte du destin des cellules souches fournit non seulement des demandes d'énergie et de molécules précurseurs, mais joue également un rôle dans le remodelage de la chromatine. Dans les embryons de vertébrés, les cellules de la crête neurale (NC) constituent une population remarquable de progéniteurs embryonnaires qui, lors de la délamination du tube neural dorsal, d'une migration et d'une différenciation étendues, donnent lieu à des dérivés neuraux/neuronaux et mésenchymateux. Le potentiel de différenciation des cellules NC nécessite un remodelage épigénétique

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8

Schock, Elizabeth N. B. S. "The Role of Primary Cilia in Neural Crest Cell Development." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504800027927076.

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9

Dickens, Claire Julia. "A study of ion regulatory mechanisms in neural crest cells and fibroblasts." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287255.

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10

Rossi, Christy Cortez. "Early development of two cell populations at the neural plate border : rohon-beard sensory neurons and neural crest cells /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Neuroscience) -- University of Colorado Denver, 2008.<br>Includes bibliographical references (leaves 112-120). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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11

McLennan, Rebecca. "Expression and function of EphA4 and ephrin-As in avian trunk neural crest migration /." free to MU campus, to others for purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p3144440.

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12

Darrigrand, Jean-François. "Influence of BMP signaling on neural crest cells during heart outflow tract septation." Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS085.pdf.

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La voie d’éjection cardiaque (VEC) est initialement un tube unique, qui se divise ensuite en artère aorte (Ao) et pulmonaire (Pa) au cours du développement embryonnaire. Cette morphogenèse est régulée par les cellules de crête neurale (CCN) qui colonisent la VEC et se condensent le long de l’endocarde, entraînant sa rupture et la formation des Ao et Pa. Des recherches ont montré que les Bone Morphogenetic Proteins (BMP) contrôlent le comportement des CCN durant ce processus. Cependant, les cascades moléculaires impliquées sont méconnues. Afin de mieux comprendre ces cascades moléculaires nous

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13

Frith, Thomas J. R. "Delineating the signals in anterior-posterior patterning of hPSC derived neural crest cells." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19471/.

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14

Yang, Xiu. "ALTERED NEURONAL LINEAGES IN THE FACIAL GANGLIA OF Hoxa2 MUTANT MICE." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1207189742.

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15

Mills, Alexandra Noelle. "Wolf-Hirschhorn Syndrome related genes are implicated in neural crest cell migration during development." Thesis, Boston College, 2018. http://hdl.handle.net/2345/bc-ir:108021.

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Thesis advisor: Laura Anne Lowery<br>Wolf Hirschhorn Syndrome (WHS) is a neurodevelopmental disorder characterized by craniofacial malformations, heart and skeletal defects, intellectual disability as well as seizure disorders. While this disorder is thought to arise from a deletion of a region on the short arm of chromosome 4, which includes the four genes WHSC1, WHSC2, LETM1 and TACC3, the mechanism by which loss of these genes results in WHS is not understood. Given that these genes have been linked to cell migration and that affected tissues include those derived from the neural crest, we

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16

Fu, Ming, and 付明. "Neural crest cell development in the nervous system of normal gut and in Hirschsprung's disease." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29281970.

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17

McKenzie, Ian 1977. "The neural crest origins of skin-derived precursors : an accessible source of myelinating Schwann cells." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100654.

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Skin-derived precursors are multipotent stem cells capable of differentiation into neural and mesodermal progeny. Described here is evidence that SKPs are of a neural crest origin; SKPs neural progeny are peripheral in subtype including peripheral catecholaminergic neurons and Schwann cells, SKPs express embryonic neural crest transcription factors, SKPs migrate via neural crest migratory pathways when transplanted into chick embryos and SKPs respond to factors know to influence neural crest stem cell differentiation in a similar manner. The expression of the neural crest transcription factors

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18

Foster, K. E. "The role of neural crest cells in the development, organisation and migration of the thymus." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19301/.

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Neural Crest (NC) derived mesenchyme has previously been shown to play an important role in the early development of the foetal thymus. Using Wnt1-Cre and Sox10-Cre mice crossed to Rosa26eYfp reporter mice, NC derived mesenchymal cells were revealed in the adult murine thymus. It is reported here that NC derived cells infiltrate the thymus before E13.5, and differentiate into cells with characteristics of smooth muscle cells associated with large vessels, and pericytes associated with capillaries. In the adult organ at three months of age, NC derived perivascular cells continue to be associate

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19

Millington, Grethel. "Primary Cilia-dependent Gli Processing in Neural Crest Cells is Required for Early Tongue Development." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479815997983138.

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20

Marathe, Himangi. "SWI/SNF Chromatin Remodeling Enzymes as Regulators of Neural-crest Derived Cell Differentiation." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1374233816.

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21

Yoshimatsu, Masayoshi. "In vivo regeneration of rat laryngeal cartilage with mesenchymal stem cells derived from human induced pluripotent stem cells via neural crest cells." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265189.

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京都大学<br>新制・課程博士<br>博士(医学)<br>甲第23417号<br>医博第4762号<br>新制||医||1052(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授松田秀一特定拠点, 教授妻木範行, 教授安達泰治<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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22

Ainsworth, Sophie Jane. "Avian development and disease : the importance of cranial neural crest cells in understanding cartilage repair strategies." Thesis, University of Brighton, 2009. https://research.brighton.ac.uk/en/studentTheses/3ab2e0e6-4897-4350-b5f4-09353049d1e0.

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Improving cartilage repair is a problem faced by scientists and clinicians alike who study and treat a wide variety of diseases including osteoarthritis (OA). OA has recently been seen with greater frequency in the western world due to the increasingly aging population. At present the possibility of using multipotent cells in treatments for OA is an exciting possibility that has been met with difficulties.

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23

Brindley, Gemma. "The role of cardiac neural crest cells in the development of the outflow tract of the heart." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413391.

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24

Komatsu, Koji. "Meltrin β expressed in cardiac neural crest cells is required for ventricular septum formation of the heart". Kyoto University, 2007. http://hdl.handle.net/2433/135667.

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25

Losa, Llabata Marta. "Gene regulation in embryonic development." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/gene-regulation-in-embryonic-development(8a9efb79-1ca9-409e-89b9-9d66213e593f).html.

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Branchial arches (BAs) are a series of transient structures that develop on the ventro-lateral surface of the head in vertebrate embryos. BAs initially appear as a series of similar segments; as development proceeds each BA will contribute to different structures. Here, it was investigated the transcriptional mechanisms that instruct the different fates of the BAs in development. Initially, each BA contains a blood vessel, known as aortic arch (AA) artery, that connects the dorsal aorta with the heart. Remodelling of the AAs is crucial to form the adult heart circulation. This process leads to

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26

Philip, Beatrice. "An Investigation Into the Molecular Mechanisms and Genes Involved in Hypoxic Signalling Pathways in Neural Crest Derived Tumours." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/367341.

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Hypoxia-inducing factors (HIF’s) are master regulators of metastasis in most solid tumours because of their ability to cause rapid cell proliferation, glycolytic metabolism, angiogenesis, and tumour invasiveness. Considerable progress has been made in defining HIF function in many hallmarks of carcinogenesis, including primary and metastatic tumour aggressiveness, poor prognosis, radio and chemotherapeutic resistance, vascular remodelling, inflammation, and hypoxia/ischemia induced cell damage. Hypoxic activation of HIF’s is gaining prominence in many cancer types as an essential mediator of m

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27

Matthews, Helen Katherine. "A role for Syndecan-4 and PCP signalling in controlling directional migration of neural crest cells in vivo." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/15955/.

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The neural crest (NC) is an embryonic population of cells, which delaminate from the neural tube epithelium to become vigorous migratory cells that colonise the entire embryo and give rise to many different derivatives. Neural crest migration requires activation of the non-canonical Wnt/planar cell polarity (PCP) signalling pathway, but it is not known exactly how this pathway controls cell migration. Here I show that the PCP ligand, Wnt11R, and the downsteam PCP element, Dishevelled, are essential for neural crest migration in Xenopus laevis embryos. Additionally, the proteoglycan, Syndecan-4

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28

Ngamjariyawat, Anongnad, Kyril Turpaev, Svitlana Vasylovska, Elena N. Kozlova, and Nils Welsh. "Co-Culture of Neural Crest Stem Cells (NCSC) and Insulin Producing Beta-TC6 Cells Results in Cadherin Junctions and Protection against Cytokine-Induced Beta-Cell Death." Uppsala universitet, Neuroanatomi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-198839.

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PURPOSE: Transplantation of pancreatic islets to Type 1 diabetes patients is hampered by inflammatory reactions at the transplantation site leading to dysfunction and death of insulin producing beta-cells. Recently we have shown that co-transplantation of neural crest stem cells (NCSCs) together with the islet cells improves transplantation outcome. The aim of the present investigation was to describe in vitro interactions between NCSCs and insulin producing beta-TC6 cells that may mediate protection against cytokine-induced beta-cell death. PROCEDURES: Beta-TC6 and NCSC cells were cultured ei

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29

Hjerling-Leffler, Jens. "Sensory neurons: stem cells and development /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-667-0/.

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30

Bradshaw, Lucy. "The-role of neural crest cells in the septation of the cardiac outflow and the effects of vitamin supplementation." Thesis, University of Newcastle upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485859.

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Septation of the initially single cardiac outflow tract (OFT) into the distinct vessels of the aorta and pulmonary trunk is a crucial step in the development ofthe mature heart and is dependent upon two cell types; cardiac neural crest cells (NCe) and a contribution from the secondary heart field. Vitamin supplementation has been implicated as one of a number of environmental 'factors to influence the occurrence of congenital heart defects. Folic acid has been shown to rescue some neural tube and conotruncal heart defects whereas retinoic acid is critical for the formation of the outflow tract

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31

Rabadán, Lozano M. Ángeles. "Genetic analysis of neural crest migration: Requirement of Dapper2-mediated inhibition of the Wnt canonical activity." Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/83279.

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Numerous initiatives to improve our understanding of cancer biology have been lunched in different laboratories that aim to describe the interactome and gene-expression profile in different tumour cell line. It is now clear that the different strategies of cell migration observed in cancer are reminiscent of the different migratory strategies observed during embryo development. These similarities suggest that developmental program that has to be kept off after embryogenesis may be induced by spontaneous genetics modifications that produce tumour cells. In this study we went inside the gene

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32

Poon, Hiu-ching. "A study of the regulatory roles of Hedgehog in the enteric nervous system development by the conditional knockout of Patched1 enteric gene in the enteric neural crest cells." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841604.

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33

Zer, Heba al [Verfasser], and Ralf [Akademischer Betreuer] Smeets. "Enrichment and Characterization of Neural Crest - derived Dental Pulp Stem Cells from Human Dental Pulp / Heba Al-Zer. Betreuer: Ralf Smeets." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2015. http://d-nb.info/106893154X/34.

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34

Poon, Hiu-ching, and 潘曉澄. "A study of the regulatory roles of Hedgehog in the enteric nervous system development by the conditional knockout of Patched1 entericgene in the enteric neural crest cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841604.

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35

Acuña, Mendoza Soledad. "Sources alternatives de cellules souches pour la bio-ingénierie de la dent." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB101.

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Les cellules de la crête neurale (CN) sont une population de cellules multipotentes que pendant le développement embryonnaire vont migrer et se différencier vers divers lignages comme mélanocytes, muscle lisse, neurones périphériques et entériques, glie ainsi que tissus mésenchymateux cranio-faciaux y compris ceux de la dent. Dans le contexte de l’étude de modèles pour l’ingénierie tissulaire de la dent, nous avons établi une nouvelle lignée de cellules souches embryonnaires (ES) à partir de blastocystes issus de croisements entre un souris Wnt1-Cre et souris rapportrices fluorescentes, les Ro

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36

Sharma, Vipul. "Vangl2 as a key regulator of cell behaviour within the developing cardiac outflow tract : elaborating specific roles in second heart field and neural crest cells." Thesis, University of Newcastle upon Tyne, 2014. http://hdl.handle.net/10443/2611.

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ii Abstract Vangl2 is a key member of the multi-protein planar cell polarity (PCP) pathway. Previous studies using the loop-tail (Lp) mouse, which carries a mutation in the Vangl2 gene, have shown that PCP is required for normal development of the cardiac outflow tract. The main cell types involved in development of the outflow tract are neural crest cells (NCC) and cells derived from the second heart field (SHF). The PCP pathway plays important roles in polarisation of cells within tissues and in directional cell movements. I hypothesised that PCP signalling is required for efficient movement

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37

Atashpazgargari, S. "A CELL REPROGRAMMING-BASED APPROACH TO STUDY 7Q11.23 GENE DOSAGE IMBALANCES IN WILLIAMS BEUREN SYNDROME AND AUTISM SPECTRUM DISORDER." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/264765.

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Symmetrical gene dosage imbalances at 7q11.23 chromosomal region cause two unique neurodevelopmental diseases, Williams Beuren Syndrome (WBS) and the 7q11.23 microduplication associated to autistic spectrum disorder (7dup-ASD). Although both these diseases share common features such as intellectual disability and craniofacial dysmorphism, they can be distinguished by distinct social and language abilities: WBS patients characterized by hypersociality and comparatively well-preserved language skills while 7dup-ASD is associated with impairment in social interaction and communicative skills. Th

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38

Repele, Andrea. "Differentiation potential and metabolic analysis of satellite cells and amniotic fluid stem cells." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422458.

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We have recently characterized two distinct populations of Satellite Cells (SCs), defined as Low Proliferative Clones (LPC) and High Proliferative Clones (HPC), that differ for proliferation, egenerative potential and mitochondrial coupling efficiency. In here, we have deep investigated their cell biology and characterized features that remark their intrinsic differences retrievable also at the initial phases of their cloning. LPC and HPC can indeed be istinguished for characteristic mitochondrial membrane potential (ΔΨm) just after isolation from their parental fibre. This is merged by mitoch

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39

Schizas, Nikos. "Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers." Doctoral thesis, Uppsala universitet, Ortopedi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251477.

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The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. Regulation of these pathways using immunomodulatory and neuroprotective substances potentially protects the injured spinal cord from further damage. We also developed and studied resorbable biomaterials to be used as carriers for potential neuroprotectants to the injured spinal cord. We used transversal spinal cord slice cultures (SCSCs) derived from postnatal mice as a model. S

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Ferronha, Tiago Guimaràes. "The contribution of LMO4 to neural development: generatin neuronal subtypes in the dorsal spinal cord and controlling EMT in neural crest cells and Neuroblastoma = La contribución de LMO4 al desarrollo neural: la generación de subtipos neuronales de la médula dorsal espinal y el control de la EMT en las células de la cresta neural y de Neuroblastoma." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/127186.

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The formation of the central nervous system (CNS) requires the generation of a remarkable diversity of neurons, which must be produced in adequate amounts in the location and timing during development. Studies on the development of the spinal cord, the caudal and simpler anatomically vertebrate CNS, have shown that the neuronal diversity is progressively acquired through the processes of cell type specification. In amniotes, patterning of the neural tube along the dorsal-ventral axis generate 11 distinct domains of neural progenitors. Thus, the developing spinal cord, may be subdivided into 6

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Loison-Robert, Ludwig. "Cellule souche gingivale : origine et multipotence." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0083/document.

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La gencive correspond à un modèle de régénération naturelle grâce notamment à sa capacité de cicatrisation « ad integrum ». Ce phénomène est permis par sa composition en fibroblastes gingivaux. Ces cellules, composante cellulaire principale du tissu conjonctif gingival, sont au cœur de la régulation des réponses inflammatoires et de la cicatrisation. Ce tissu contient, comme d’autres tissus mésenchymateux, des cellules souches ; qui expliquent en partie ces capacités de régénération. De plus, comme le tissu gingival est abondant et facilement accessible, l’utilisation de ces cellules souches p

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42

Workman, Michael J. "Generating 3D human intestinal organoids with an enteric nervous system." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1416570664.

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Grapensparr, Liza. "Auxiliary Cells for the Vascularization and Function of Endogenous and Transplanted Islets of Langerhans." Doctoral thesis, Uppsala universitet, Integrativ Fysiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327314.

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Type 1 diabetes develops through the progressive destruction of the insulin-producing beta-cells. Regeneration or replacement of beta-cells is therefore needed to restore normal glucose homeostasis. Presently, normoglycemia can be achieved by the transplantation of whole pancreas or isolated islets of Langerhans. Islet transplantation can be performed through a simple laparoscopic procedure, but the long-term graft survival is low due to poor revascularization and early cell death. This thesis examined the possibility of using different auxiliary cells (Schwann cells, endothelial progenitor ce

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44

Latta, Elizabeth Janet. "Studies of the tissues and molecules that regulate the migration of cranial neural crest cells in the chicken embryo : roles of Midline 1 and retinoic acid." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.527449.

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45

Oldenburg, Denise [Verfasser], Beate [Gutachter] Brand-Saberi, and Carsten [Gutachter] Theiß. "The role of the cephalic neural crest cells in the development of the limbal stem cell niche of the chicken cornea / Denise Oldenburg ; Gutachter: Beate Brand-Saberi, Carsten Theiß ; Medizinische Fakultät." Bochum : Ruhr-Universität Bochum, 2018. http://d-nb.info/1171521901/34.

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46

Gazquez, Elodie. "Études des interactions fonctionnelles entre l'endothéline-3, les intégrines beta1 et les propriétés élastiques du tissu embryonnaire au cours du développement du système nerveux entérique." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066240/document.

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Le système nerveux entérique (SNE) provient des cellules de crête neurale entériques (CCNEs) qui migrent au sein de l'intestin embryonnaire, prolifèrent et se différencient en cellules gliales et neurones formant des ganglions interconnectés. Mon projet de thèse vise à comprendre comment les propriétés biochimiques et mécaniques de l'intestin embryonnaire influencent la colonisation et la différenciation des ccnes. L'absence d'endothéline-3 (EDN3), un facteur biochimique exprimé dans la paroi intestinale, est une des causes de la maladie de hirschsprung, caracterisée par une aganglionose du cô

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47

Ferré, François. "Isolation et caractérisation des cellules souches gingivales : étude de leur potentiel multipotent." Phd thesis, Université René Descartes - Paris V, 2013. http://tel.archives-ouvertes.fr/tel-01017172.

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Les capacités de cicatrisation de la gencive en font un modèle de régénération tissulaire naturelle. Ces capacités sont liées en grande partie à l'activité des fibroblastes. Composante cellulaire principale du tissu conjonctif gingival, ils sont au cœur de la régulation des réponses inflammatoires et des processus de cicatrisation. Nous avons supposé que ce tissu pouvait contenir des cellules souches, pouvant expliquer en partie, ces capacités de réparation. Au cours de cette thèse, nous avons pu mettre en évidence la présence de cellules souches mésenchymateuses aux propriétés communes avec l

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48

Gazquez, Elodie. "Études des interactions fonctionnelles entre l'endothéline-3, les intégrines beta1 et les propriétés élastiques du tissu embryonnaire au cours du développement du système nerveux entérique." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066240.pdf.

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Le système nerveux entérique (SNE) provient des cellules de crête neurale entériques (CCNEs) qui migrent au sein de l'intestin embryonnaire, prolifèrent et se différencient en cellules gliales et neurones formant des ganglions interconnectés. Mon projet de thèse vise à comprendre comment les propriétés biochimiques et mécaniques de l'intestin embryonnaire influencent la colonisation et la différenciation des ccnes. L'absence d'endothéline-3 (EDN3), un facteur biochimique exprimé dans la paroi intestinale, est une des causes de la maladie de hirschsprung, caracterisée par une aganglionose du cô

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Radu, Anca Gabriela. "Nouvelles régulations métaboliques exercées par la signalisation LKB1 dans les cellules polarisées : conséquences pour l’ontogénie tissulaire." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV011/document.

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Le suppresseur de tumeur et sérine/thréonine kinase LKB1 est un régulateur clé de la polarité cellulaire et du métabolisme énergétique en partie grâce à l'activation de sa kinase substrat AMPK. Cette protéine est un senseur métabolique pour adapter les apports énergétiques aux besoins nutritionnels des cellules confrontées à un stress. Pour cela, AMPK phosphoryle divers substrats qui activent les réactions cataboliques et inhibent les processus anaboliques dont la kinase mTOR.Au cours de ma thèse, via l’utilisation de modèles murins d’inactivation conditionnelle, j'ai découvert que Lkb1 est cr

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Bahm, Isabel. "PDGF signalling during Neural Crest Cell migration." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041758/.

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Neural crest cells are a transient cell population, which migrates through the vertebrate embryonic body, and eventually gives rise to a many different cell types in the adult. Contact inhibition of locomotion (CIL) is a fundamental property of the collective migrating neural crest cells. CIL describes a process by which colliding cells change their direction upon collision and move away from each other, which has been linked to cell dispersion, boundary formation and metastasis. CIL is acquired in neural crest cells during Epithelial-to-Mesenchymal-Transition (EMT), by a switch in the express

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