Academic literature on the topic 'NEU-Med'

SummaryOb in der Drogerie oder in der Apotheke: Die Fülle von Nahrungsergänzungsmitteln ist enorm. Hinzu kommen neu erscheinende Studien sowie zahlreiche Werbebotschaften. Dadurch ist es oft schwierig, den Überblick über relevante Mittel und ihre validen Anwendungsmöglichkeiten zu behalten. Im Gespräch mit Dr. med. Volker Schmiedel erfahren wir mehr über verschiedene Zusammenhänge und sinnvolle sowie womöglich weniger sinnvolle Anwendungen von Nahrungsergänzungsmitteln.

Abstract. In this study we analyze drought features at the European level over the period 1901–2019 using three drought indices: the standardized precipitation index (SPI), the standardized precipitation evapotranspiration index (SPEI), and the self-calibrated Palmer drought severity index (scPDSI). The results based on the SPEI and scPDSI point to the fact that Central Europe (CEU) and the Mediterranean region (MED) are becoming dryer due to an increase in the potential evapotranspiration and mean air temperature, while North Europe (NEU) is becoming wetter. By contrast, the SPI drought does not reveal these changes in the drought variability, mainly due to the fact that the precipitation does not exhibit a significant change, especially over CEU. The SPEI12 indicates a significant increase both in the drought frequency and area over the last three decades for MED and CEU, while SPI12 does not capture these features. Thus, the performance of the SPI may be insufficient for drought analysis studies over regions where there is a strong warming signal. By analyzing the frequency of compound events (e.g., high temperatures and droughts), we show that the potential evapotranspiration and the mean air temperature are becoming essential components for drought occurrence over CEU and MED. This, together with the projected increase in the potential evapotranspiration under a warming climate, has significant implications concerning the future occurrence of drought events, especially for the MED and CEU regions.

Background : Colorectal carcinoma (CRC) is the most frequently observed malignancy worldwide. The incidence of CRC is 3.5% in Bangladesh. Conflicting data exist about the prevalence of HER-2/neu over expression in colorectal cancer ranging from 0 to 83%. The aim of this study was to evaluate the expression of Her-2/neu protein in colorectal cancers.
 Materials and methods: This descriptive cross-sectional study was conducted in the Department of Pathology of Chittagong Medical College, Chittagong, Bangladesh from 1st January 2017 to 31st December 2017. A total of 52 cases with a histopathological diagnosis of colorectal cancers included in the study as sample size, HER2 status was evaluated by immunohistochemistry (IHC) in formalin fixed, paraffin embedded tissue.Positive expression was assigned a score from 0–3+.IHCs were analysed with grades of colon cancers.
 Results: The mean age in this study was 47.62years range from 12 to 85 years ,53.8% were female. Among 52 specimens 30 (57.7%) cases were from colon and all the cases were adenocarcinoma and rest of all (42.3%) were from rectum.33 (63.5%) cases were Grade-I, 8 (15.4%) were Grade-II, and 11 (21.2%) were Grade-III. Only 8 (15.4%) of 52 cases showed HER2 positive, 4 (50.0%) cases were from grade- Iand another 4 (50.0%) were grade- II tumours. HER2 overexpression were significantly associated with well differentiated CRC than poorly differentiated (p=0.044).
 Conclusion: HER2/neu protein expression was observed in colorectal cancer but HER-2/neu protein is less likely to be expressed in colon cancer cell lines among our patients.
 Chatt Maa Shi Hosp Med Coll J; Vol.21 (1); January 2022; Page 52-56

582 Background: DD q 2 weekly (w) AC → T is superior to conventionally scheduled (cs) AC → T and safe w/long follow-up (Hudis et al, SABCS 2005). With q 3 wk AC, adjuvant (adj) H is safe and effective (Romond et al and Perez et al, NEJM 2005). We therefore tested DD q 2 w AC → T + H × 1 year (y) as adj treatment (Rx) of patients (pts) with HER2/neu (+) BCA to determine cardiac safety. Based on the reported cardiac event (CE) rate of ≤ 4% in the randomized trials using cs chemotherapy (CRx) + H, we evaluated DD q 2 w AC → T + H with a 1° endpoint of cardiac safety defined as discontinuation (DC) of H due to 1) cardiac death or 2) congestive heart failure (CHF). The 2° endpoint is time to recurrence and overall survival. Methods: Pts with HER2/Neu IHC 3+ or FISH-amplified BCA were enrolled, regardless of tumor size or nodal status. Rx consisted of AC at 60/600 mg/m2 × 4 → T at 175 mg/m2 × 4 q 2 w w/pegfilgrastim 6 mg on d 2 + H × 1 y. Multi-gated radionuclide angiography scan (MUGA) is obtained at baseline and at months (mo) 2 (after AC × 4), 6 (after T × 4), 9, and 18. Pts w/baseline LVEF of ≥ 55% and w/o cardiac illnesses are eligible. Pts w/significant (sig) asymptomatic (asx) LVEF ↓ after DD AC based on mo 2 MUGA did not receive H, and pts w/sig asx LVEF ↓ during H had it DC’d. If the CE rate is > 4%, Rx is deemed not feasible. Results: From January 4, 2005 to November 1, 2005, 70 pts were enrolled. Median (med) age is 49 years (range, 27–72). Forty one of 70 pts (60%) had node (+) BC and 27/70 pts (40%) had (-) nodes. Med baseline LVEF is 68% (range, 55%-81%). As of January 9, 2005, all pts had mo 2 MUGA after DD AC and there is no sig LVEF ↓ and the med LVEF is 67% (range, 58%-79%). To date 39 pts had mo 6 MUGA w/med LVEF of 66% (range, 56%-75%) and one pt had a sig asx LVEF ↓ from baseline of 74% to 56%; H was DC’d. Twenty-three pts had mo 9 MUGA w/a med LVEF of 64% (range, 57%-69%). One patient had clinical CHF at mo 4 w/EF of 45% and improved sig w/cardiac medications. One had pneumonitis during radiation (RT). One had atrial fibrillation w/pericarditis after completion of RT. Discussion: DD AC → T + H appears to have an acceptable cardiac toxicity profile w/1/70 pts having a CE. Updated cardiac safety data will be presented. [Table: see text]

Introduction: Now a days immunohistochemistry and genomic testing for patient with Non- Small Cell Lung Cancer (NSCLC) is becoming new standard of care in clinical decision making. A renewed interest has been emerging on the human epidermal growth factor-2 (HER2) pathway. Aim of this present study was clinicopathological correlation of HER-2/neu expression by IHC in NSCLC. Method: This was a Cross sectional and observational study done at Sir Salimullah Medical College and National Institute of Disease of the Chest and Hospital (NIDCH) and other private hospitals in Dhaka city during July / 2014 to June / 2016. Adult of both gender with histologically diagnosed as a case of NSCLC was include in the study. Immunohistochemistry was done to see the positivity for HER/neu and clinical characteristics were observed. Result: A total 45 patients with NSCLC were enrolled in the study. Male was 77.8% (n=35) and female was 22.2% (n=10). The mean age was 55.67 (SD± 12) years and mean age of male was higher compared to female (57.54±11.64 years verses 49.1±11.38 years). Most of the male were smokers (71.1%) and female were nonsmokers (90%). 57.78% (n=26) of patients and 42.22% (n=19) of patients had adenocarcinoma and squamous cell carcinoma respectively. Most squamous cell carcinoma patients were elderly, had wasting and having higher TNM staging. Serum LDH level was higher with advance staging and grading. Only 8.89% (n=4) had HER-2/neu positive expression affected by male. Patients with HER 2/neu positive expression were relatively older (mean age 62.5±17.08). However, there were equal in histopathological categorization (50% SCC and 50% Adenocarcinoma). Mean LDH was slightly higher in HER-2 positive patients was compared to HER-2 negative patients (569.5±232.6 versus 469.7±181.8). Conclusion: About nine percent of patients having HER-2/neu positive was relatively older and had more high level of LDH. A large-scale study should be conducted in Bangladeshi population to characterize epidemiological, clinicopathological feature in patients with NSCLC with HER-2 expression. J Dhaka Med Coll. 2021; 29(1): 99-110

Genetic parameters for liveweight (LWT), greasy fleece weight (GFW), mean fibre diameter (MFD), standard deviation of MFD (MFD-s.d.), mean fibre curvature (CURVE) percentage of medullated (%MED) and kemp (%KEMP) fibres, faecal worm egg count (WEC), packed cell volume (PCV), mean corpuscular volume (MCV) mean corpuscular haemoglobin content (MCHC), circulating anti-nematode IgG (IgG) and counts of circulating eosinophils (EOS), lymphocytes (LYM), neutrophils (NEU), basophils (BASO) and monocytes (MONO) up to 18 months of age were estimated in Australian Angora goats (608 animals, 14 sires 3 years of birth). Measurements were made during a period of natural parasite challenge up to 5 months of age, or following artificial challenge with 10 000 infective larvae of Trichostrongylus colubriformis at 5.25 months of age. Year of birth had a significant impact on production and parasite-associated traits at all ages studied. Sex had a marked effect on production and erythrocyte traits. Birth type had no effect on any traits in animals older than 6 months. Maternal effects were not significant except for LWT at 3, 5 and 6 months and for IgG at 3 months. Most production traits were highly (LWT, GFW, MFD, %MED) or moderately (CURVE, MFD-s.d.) heritable (range 0.17–0.59) with only %KEMP having a low heritability (0.02–0.14). The heritability estimates (±s.e.) for CURVE are novel for goats and ranged from 0.18 ± 0.09 at first shearing to 0.44 ± 0.14 at third shearing. Heritability estimates were low for WEC (0.02–0.16) and for specific IgG during natural infection (0.14–0.15) but higher for IgG following artificial challenge with T. colubriformis (0.42 ± 0.13). Of the haematological variables NEU and all red cell traits were highly heritable (0.45–0.71), LYM and MONO were moderately to highly heritable (0.31–0.55), and EOS was weakly to moderately heritable (0.06–0.28). Strong phenotypic correlations existed between production traits. MFD was positively correlated with GFW and negatively correlated with CURVE, indicating that finer fibres have a higher crimp or wave count. WEC had consistent negative phenotypic correlations with PCV, LYM and EOS, and positive correlations with NEU. Correlations with IgG were positive up to 5 months and negative thereafter. Phenotypic correlations between WEC and LWT as well as with GFW and MFD were negative. Heritability estimates for production traits were generally consistent with other studies. Haematological and fibre curvature findings are completely novel for Angora goats. Estimates of heritability for WEC fell in mid range of published findings for other goat breeds, and these results suggest that there is some scope for breeding for worm resistance in Angoras but the response is likely to be slow.

Background & objective: The importance of establishing hormone receptor status of tumors for the treatment of women with hormone receptor-positive breast cancer is often emphasized. It is critical to evaluate hormone receptor status when considering response to endocrine therapy. The present study was intended to evaluate the usefulness of hormone receptor status in breast carcinoma.
 Materials & Methods: The present study was conducted in the Department of Pathology, Dhaka Medical College, Dhaka over a period 12 months from July 2009 to June 2010. A total of 30 histopathologically diagnosed cases of breast tumors who were also subjected to immunohistochemical (IHC) test for ER, PR status and HER-2/neu were consecutively included in the study. Patients who have already been treated for malignancy or who had a history of receiving radiotherapy were excluded.
 Result: Age distributions shows that 40% of the patients were early middle-aged (30-40 years), 30% middle-aged and the rest were either < 30 years or >50 years old. Left breast was involved more often (56.7%) than the right breast (43.3%). The predominant location was upper outer quadrant (43.3%), followed by upper inner quadrant (20%), lower outer quadrant (20%), lower inner quadrant (10%) and central (6.7%). Over half (53.3%) of the tumors were < 5 cm and the rest 5 cm or more. Nearly half (46.7%) of the tumors were moderately differentiated, 36.6% well-differentiated and 16.7% poorly differentiated. In majority (83.3%) of the cases lymph-nodes (axillary lymph nodes) were involved. Based on estrogen and progesterone receptor status, over half (53.3%) of the tumors were ER and PR positive and 40% were Her2/neu overexpressed.
 Conclusion: The study concluded that half of the Bangladeshi breast cancer patients are ER and PR positive and two in every five cases are Her2/neu overexpressed.
 J Shaheed Suhrawardy Med Coll, December 2018, Vol.10(2); 70-73