Dissertations / Theses on the topic 'Nervous system Computer simulation'

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1

Sorensen, Michael Elliott. "Functional Consequences of Model Complexity in Hybrid Neural-Microelectronic Systems." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6908.

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Hybrid neural-microelectronic systems, systems composed of biological neural networks and neuronal models, have great potential for the treatment of neural injury and disease. The utility of such systems will be ultimately determined by the ability of the engineered component to correctly replicate the function of biological neural networks. These models can take the form of mechanistic models, which reproduce neural function by describing the physiologic mechanisms that produce neural activity, and empirical models, which reproduce neural function through more simplified mathematical expressions. We present our research into the role of model complexity in creating robust and flexible behaviors in hybrid systems. Beginning with a complex mechanistic model of a leech heartbeat interneuron, we create a series of three systematically reduced models that incorporate both mechanistic and empirical components. We then evaluate the robustness of these models to parameter variation, and assess the flexibility of the models activities. The modeling studies are validated by incorporating both mechanistic and semi-empirical models in hybrid systems with a living leech heartbeat interneuron. Our results indicate that model complexity serves to increase both the robustness of the system and the ability of the system to produce flexible outputs.
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2

Denizot, Audrey. "Simulation de la signalisation calcique dans les prolongements fins astrocytaires." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEI093/document.

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Les astrocytes sont des cellules gliales du système nerveux central, essentielles à la formation des synapses, à la barrière hémato-encéphalique ainsi qu’au maintien de l'homéostasie. Récemment, les astrocytes ont été identifiés comme éléments clés du traitement de l'information dans le système nerveux central. Les astrocytes peuvent communiquer avec les neurones au niveau des synapses et moduler la communication neuronale en libérant des gliotransmetteurs et en absorbant des neurotransmetteurs. L’utilisation de nouvelles techniques comme la microscopie à super-résolution et les indicateurs calciques encodés génétiquement a permis de révéler une grande diversité spatio-temporelle des signaux calciques astrocytaires. La majorité de ces signaux sont observés au sein de leurs prolongements cellulaires, qui sont le site de communication entre neurones et astrocytes. Ces prolongements sont trop fins pour être observés en microscopie optique conventionnelle, de sorte que la microscopie à super-résolution et la modélisation informatique sont les seules méthodes adaptées à leur étude. Les travaux présentés dans cette thèse ont pour but d’étudier l'effet des propriétés spatiales (telles que la géométrie cellulaire, les distributions moléculaires et la diffusion) sur les signaux calciques dans les prolongements astrocytaires. Historiquement, les signaux calciques ont été modélisés à l'aide d'approches déterministes non spatiales. Ces modèles ont permis l'étude des signaux calciques à l’échelle de la cellule entière voire à l’échelle du réseau de cellules. Ces méthodes ne prennent cependant pas en compte la stochasticité inhérente aux interactions moléculaires ainsi que les effets de diffusion, qui jouent un rôle important dans les petits volumes. Cette thèse présente un modèle stochastique et spatial qui a été développé dans le but d’étudier les signaux calciques dans les prolongements fins astrocytaires. Ce travail a été réalisé en collaboration avec des expérimentateurs, qui nous ont fourni des données de microscopie électronique et à super-résolution. Ces données ont permis de valider le modèle. Les simulations du modèle suggèrent que (1) la diffusion moléculaire, fortement influencée par la concentration et la cinétique des buffers calciques endogènes et exogènes, (2) l'organisation spatiale intracellulaire des molécules, notamment le co-clustering des canaux calciques, (3) la géométrie du reticulum endoplasmique et sa localisation dans la cellule, (4) la géométrie cellulaire influencent fortement les signaux calciques et pourraient être responsables de leur grande diversité spatio-temporelle. Ces travaux contribuent à une meilleure compréhension du traitement de l’information par les astrocytes, un prérequis pour une meilleure compréhension de la communication entre les neurones et les astrocytes ainsi que de son influence sur le fonctionnement du cerveau
Astrocytes are predominant glial cells in the central nervous system, which are essential for the formation of synapses, participate to the blood-brain barrier and maintain the metabolic, ionic and neurotransmitter homeostasis. Recently, astrocytes have emerged as key elements of information processing in the central nervous system. Astrocytes can contact neurons at synapses and modulate neuronal communication via the release of gliotransmitters and the uptake of neurotransmitters. The use of super-resolution microscopy and highly sensitive genetically encoded Ca2+ indicators (GECIs) has revealed a striking spatiotemporal diversity of Ca2+ signals in astrocytes. Most astrocytic signals occur in processes, which are the sites of neuron-astrocyte communication. Those processes are too fine to be resolved by conventional light microscopy so that super-resolution microscopy and computational modeling remain the only methodologies to study those compartments. The work presented in this thesis aims at investigating the effect of spatial properties (as e.g cellular geometry, molecular distributions and diffusion) on Ca2+ signals in those processes, which are deemed essential in such small volumes. Historically, Ca2+ signals were modeled with deterministic well-mixed approaches, which enabled the study of Ca2+ signals in astrocytic networks or whole-cell events. Those methods however ignore the stochasticity inherent to molecular interactions as well as diffusion effects, which both play important roles in small volumes. In this thesis, we present the spatially-extended stochastic model that we have developed in order to investigate Ca2+ signals in fine astrocytic processes. This work was performed in collaboration with experimentalists that performed electron as well as super-resolution microscopy. The model was validated against experimental data. Simulations of the model suggest that (1) molecular diffusion, strongly influenced by the concentration and kinetics of endogenous and exogenous buffers, (2) intracellular spatial organization of molecules, notably the co-clustering of Ca2+ channels, (3) ER geometry and localization within the cell, (4) cellular geometry strongly influence Ca2+ dynamics and can be responsible for the striking diversity of astrocytic Ca2+ signals. This work contributes to a better understanding of astrocyte Ca2+ signals, a prerequisite for understanding neuron-astrocyte communication and its influence on brain function
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3

Thomas, Evan Alexander. "Mathematical and computer modelling of the enteric nervous system." Connect to thesis, 2001. http://repository.unimelb.edu.au/10187/2872.

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The enteric nervous system (ENS) runs within the intestinal wall and is responsible for initiating and enacting several reflexes and motor patterns, including peristalsis and the complex interdigestive motor programs, known as migrating motor complexes (MMCs). The ENS consists of several neuron types including intrinsic sensory neurons, interneurons and motor neurons. A great deal is known about the anatomy, pharmacology and electrophysiology of the ENS, yet there is almost no understanding of how enteric neural circuits perform the functions that they do and how they switch from one function to another. The ENS contains intrinsic sensory neurons (ISNs) that connect to every neuron type in the ENS, including making recurrent connections amongst themselves. Thus, they are likely to play a key role, not just in sensory transduction, but in coordination of reflexes and motor patterns. This thesis has explored how these functions are performed by developing and analysing mathematical and computer models of the network of ISNs. (For complete abstract open document)
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4

Zhang, Guoging 1963. "Knowledge based simulation system--an application in controlled environment simulation system." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/292001.

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This thesis systematically identifies the building blocks of a knowledge based system for simulation and modelling. We present the design and implementation of Controlled Environment Simulation System (CESS), which bridges a discrete event simulation system (DEVS-SCHEME) and a continuous simulation system (TRNSYS). The rationale behind the approach is that a discrete or a continuous model can be abstracted to a level at which the uniform treatment on these two kinds of models is possible. A top-down approach to model creation (abstraction) is proposed, in contrast to the traditional bottom-up approach. CESS is implemented on an object-oriented programming environment (SCOOPS on TI-SCHEME). A knowledge representation scheme known as System Entity Structure is employed for MODEL management, recording system structural knowledge, and the utilization of techniques in Artificial Intelligence. Some prospective research topics are also brought up.
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5

Belote, Greg H. "Multivehicle simulation system." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/45812.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.
Includes bibliographical references (p. 39).
In this thesis, we designed and implemented a simulator that supports multiple robots within a dynamic environment. The goal of this tool is to provide a testing environment for navigational robots that run on the MOOS platform. The simulator is written in C++ and utilizes several open source libraries to create a virtual world for robots to interact with by faking sensor information. A design goal of this thesis has been to make the simulator versatile enough to be useful for a variety of robots, from land to marine. Such a tool is valuable in research because the cost of developing a custom simulator can consume too many man-hours. Reducing this cost by creating a generic and customizable simulator has been the main motivation behind this thesis. It has also been one of the major challenges behind the project.
by Greg H. Belote.
M.Eng.
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6

Zoorob, Riad J. "S.E.S., a simulation expert system." Virtual Press, 1994. http://liblink.bsu.edu/uhtbin/catkey/897507.

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The continuous increase in the cost of building real life projects, the high cost of researches concerning a project and the urgent demands for the project to be delivered in a short period of time have urged researchers to find a new scheme of programming in which they would be able to simulate or emulate the real life activities and projects using a computer and a procedural language. But such a scheme of programming was lengthy, tedious and costly. Therefore, it was necessary to find a specialized simulation software that would save the programmer's time and effort on the one hand and would save the client's money on the other. A number of simulation software were developed recently which contributed greatly to the solutions of the simulation problems. However, none of these languages possessed the completeness nor the independence of the use of other tools or procedural languages to compensate for their deficiencies.In this paper I have proposed a number of new ideas aimed to improve the simulation languages in general, and have implemented a number of these ideas in a software package. Chapter one describes the simulation model and the basic concepts of simulation. Chapter two describes briefly the advantages and disadvantages of using simulation software. Also it outlines the limitations of currently used simulation packages. Finally, it suggests new ideas and expectations of a complete simulation package. Chapter three describes the simulation package prototype S. E. S. and gives some implementations. Chapter four explains the basic differences between S. E. S. and SLAM II and shows areas for further research.
Department of Computer Science
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7

Sedlackova, Anna. "Replicating Motion Vision and Response in Insects Using a Synthetic Nervous System." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1593309220545937.

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8

Verma, Yukti. "Secure system simulation - Internet of Things." Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10116148.

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Internet of Things (IoT) can be defined as a collection of smart devices interacting with each other unanimously to fulfill a common goal. The real world data collected from the Internet of Things can be made as an integral part of web known as Web of Things (WoT). With the help of Web of Things architecture, the users can leverage simple web mechanisms such as browsing, searching and caching to interact with the smart devices. This thesis aims to create an entire system simulating the Web of Things architecture including sensors, edge routers, web interfaces, endpoints to the IoT network and access control. Several technologies such as CoAP, 6LoWPAN, IEEE 802.15.4, contiki and DTLS have been evaluated before inclusion in the implementation. A complete web portal utilizing Californium framework and Role Based Access Control has been created for accessing and interacting with the sensors and their data. This thesis provides an end-to-end approach towards IoT device security by implementing Constrained Application Protocol (CoAP) over Datagram Transport Layer Security (DTLS) in the system. The performance of secured system is analyzed in a constrained environment based on which it is observed that DLTS implementation increases the RAM usage, code size, packet overhead and power consumption by a significant value. Finally, the future work that needs to considered in order to iterate towards better security is specified.

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9

Chadha, Vikrampal. "Simulation of large-scale system-level models." Thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-12162009-020334/.

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10

Lai, Tsz-ming Terence, and 黎子明. "Harmonic simulation of traction system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B3122281X.

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11

Martin, Timothy Patrick. "Flexible manufacturing system software development using simulation." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/101236.

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This paper presents a hierarchical modeling method that can be used to simulate a Flexible Manufacturing System (FMS) at all levels of detail. The method was developed specifically to aid the software development needed for the hierarchy of computers that are present in an FMS. The method was developed by modeling an existing FMS. The models developed of the existing FMS are described in detail to provide an example of how to model other FMSs. The basic building blocks needed for designing other FMSs with this modeling method are provided. The models were written in the SIMAN simulation language. SIMAN was found to be an easy language to use for the hierarchical modeling of FMSs.
M.S.
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12

Grygier, Paul Arthur. "Distributed Dynamic System Simulation Using a Computer Network." The Ohio State University, 1988. http://rave.ohiolink.edu/etdc/view?acc_num=osu1391676035.

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13

Jia, Yan. "Computer simulation of the lamprey spinal cord locomotor system." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610128.

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14

Arcot, Ramakant P. "Computer simulation of the Bristol compressor suspension system dynamics." Thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-09052009-040832/.

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15

Ma, Moses Hsingwen. "Efficient message-based system for concurrent simulation." Thesis, Massachusetts Institute of Technology, 1989. http://hdl.handle.net/1721.1/74802.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1989.
Title as it appeared in M.I.T Graduate List, February, 1989: Efficient message based systems for concurrent simulation.
Includes bibliographical references (leaves 267-269).
by Moses Hsingwen Ma.
Ph.D.
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16

Mak, Hing-Yin. "System dynamics and discrete event simulation modelling." Thesis, London School of Economics and Political Science (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263375.

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This thesis investigates the relationship between discrete event and system dynamics simulation modelling. Each modelling technique has its own strengths and limitations. The choice of using one particular modelling technique often depends on the preference and the knowledge of the modeller rather than on the nature of the problem. The basis of this research has been to address the problem from a different perspective. This has been to look at the nature of the problem first, and then determine the most appropriate modelling technique to apply. The basic method adopted was to compare, contrast and experiment with these two modelling techniques in order to determine a number of common and unrelated concepts between them. This investigation discovered that a system dynamics flow diagram could be used to represent an activity cycle diagram of a discrete event model. The converted flow diagram can provide a different viewpoint from the discrete event model due to the feedback characteristic of system dynamics. This research went on to develop a set of guidelines to convert an activity cycle diagram into a system dynamics flow diagram. Experimentation with many examples demonstrates that these conversion guidelines provide a consistent and systematic method for obtaining a system dynamics flow diagram. The final stage of this research was to develop a prototype computer system (SMCP) to demonstrate these guidelines. SMCP consists of two modules, the ACD module which allows the user to specify a discrete event model through textual descriptions, and the SD module which allows the user to build a system dynamics model by drawing symbols and using text inputs. In addition, SMCP allows users to convert an ACD to a system dynamics flow diagram quickly and easy, and also demonstrates the concept of data sharing.
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17

Somaiya, Sandeep R. "SENATE : a software system for evaluation of simulation results /." Master's thesis, This resource online, 1993. http://scholar.lib.vt.edu/theses/available/etd-03302010-020337/.

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18

Krishnan, Krishna Kumar. "System based ladder logic simulation and debugging." Thesis, This resource online, 1991. http://scholar.lib.vt.edu/theses/available/etd-11072008-063418/.

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19

Wang, Ding Ph D. Massachusetts Institute of Technology. "Adaptive rapid environmental assessment system simulation framework." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33592.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.
Includes bibliographical references (leaves 170-171).
Adaptive Rapid Environmental Assessment (AREA) is a new concept for minimizing the non model-based sonar performance prediction uncertainty and improving the model-based sonar performance by adaptive and rapid in situ measurement in the ocean environment. In this thesis, a possible structure of the AREA system has been developed; an AREA System Simulation Framework has been constructed using C++, which can simulate how AREA system will work and be utilized to determine the optimal or sub-optimal sampling strategies. A user's manual for the simulation framework, and specifications of all important C++ classes are included.
by Ding Wang.
S.M.
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20

Gu, Yan. "ROSENET: a remote server-based network emulation system." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22662.

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Thesis (Ph. D.)--Computing, Georgia Institute of Technology, 2008.
Committee Chair: Fujimoto, Richard; Committee Member: Ammar, Mostafa; Committee Member: Bader, David; Committee Member: Goldsman, David; Committee Member: Park, Haesun; Committee Member: Riley, George.
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21

Kasasbeh, Yousef Ahmed Mefleh. "A microcomputer-based visual system for maritime simulation." Thesis, University of Exeter, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292944.

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22

Han, Jennifer Ching-Wen. "Using system dynamics in business simulation training games." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/42762.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1997.
Includes bibliographical references (leaves 57-58).
by Jennifer Ching-Wen Han.
M.Eng.
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23

Yourkowski, Joel. "Computer simulation of an unmanned aerial vehicle electric propulsion system." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1996. http://handle.dtic.mil/100.2/ADA307294.

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24

Roberts, Christopher C. "Plan-based simulation of malicious intruders on a computer system." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1995. http://handle.dtic.mil/100.2/ADA297701.

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25

Weissmann, Eric. "Assessment of server location on system availability by computer simulation." Master's thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-10242009-020123/.

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26

Obaidat, Mohammad Salameh. "A 68000 based modular multiprocessor system : design and simulation analysis /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266362336169.

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27

El-Hadad, Kamel Abdelsalam Mahmoud. "Expert systems and simulation : an investigation of an expert system to facilitate the development and use of system dynamic simulation models." Thesis, University of Kent, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279602.

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28

Huang, GongWen 1948. "Computer aided model structuring in system design." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276903.

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As a CAD tool, the Computer Aided Model Structuring System (call MOSTS in the following text) for model structuring in system design and system simulation has been designed and implemented. First, this MOSTS allows system design experts to create and save System Data Bases (SDBs) for model structuring in system design and simulation. Then, these SDBs can be retrieved, modified, and finally used to structure system models by design engineers. The MOSTS pursues the model structuring process in such a way that the model structure having the best performance (according to the expert's knowledge and the design engineer's design criteria) will be generated first, and then the second best model, the third best model, and so on.
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Su, Ying-fung, and 蘇盈峰. "Role of temporal texture in visual system: exploration with computer simulations." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43703768.

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30

Lee, Dongchul C. "STRUCTURE-FUNCTION RELATIONSHIPS IN CENTRAL NERVOUS SYSTEM NEURONS ACTIVATED BY EXTRACELLULAR ELECTRIC FIELDS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=case1089749205.

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31

Crouch, Ingrid W. M. "A knowledge-based simulation optimization system with machine learning." Diss., Virginia Tech, 1992. http://hdl.handle.net/10919/37245.

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32

Harrichunder, Rajen. "A learning support system for the Visual Simulation Environment." Master's thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-02022010-020139/.

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33

Xiang, Luo. "A virtual Music fountain simulation based on particle system." Thesis, Högskolan i Gävle, Avdelningen för Industriell utveckling, IT och Samhällsbyggnad, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-13698.

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This report presents a real-time simulation of a music fountain which is simulated in three dimensions by a particle animation system. In this system, gravity and wind are factors that affect the locus movement of particles. Using kinematic equations, the dynamic behaviors of particles is modeled. A specific contribution of the work presented here is that parameters for the motion equation are estimated from sound playing in real-time which controls the dynamic behavior of animated fountain. An open source programming language called Processing is used to implement the environment. Results of the system are demonstrated in form of its graphical output and performance benchmarks from run-time evaluation. The author investigates the influence of the parameters of particle system and music attributes on the animation of the music fountain simulation. The size, number, color, texture and transparency of particles can influence the quality of music fountain simulation. Using FFT function to get music parameters is the best way to figure out differences between different music.
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Artica, I., G. Quispe, and C. Raymundo-Ibañeez. "Ventilation System Simulation Model at a Mine." IOP Publishing Ltd, 2019. http://hdl.handle.net/10757/656302.

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This research project modeled and simulated a ventilation system at a Mining Concession, obtaining real-time information regarding the fans used to ventilate the mine. The simulation was developed using the VENTSIM 5 software, which also helped define the number of fans and the operating parameters required, field information, mine dimensions, the mining method, production, geothermal gradient, gas emission, air stream, and air pressure. In addition, the results from software operation revealed the need to open chimneys and use fans. Furthermore, the results also suggest that a specialist dedicated to ventilation and fan maintenance must be hired to formalize mining operations as per the Occupational Safety and Health Mining Regulations from Executive Action No. 024-2016-EM as this Mining Concession is currently operating without license.
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Calvo, Gonźalez Mireia. "Analysis of the cardiovascular response to autonomic nervous system modulation in Brugada syndrome patients." Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1S056/document.

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Le syndrome de Brugada (BS) est une maladie génétique responsable de troubles du rythme cardiaque. En raison de la nature complexe et multifactorielle de cette pathologie, la stratification du risque peut s’avérer particulièrement difficile et il est nécessaire de pouvoir définir de nouveaux marqueurs avec des valeurs prédictives élevées afin d’identifier les patients à haut risque. Les événements arythmiques dans cette population étant souvent liés à des modifications de fonctionnement du système nerveux autonome (SNA), l’objectif de la thèse est l’évaluation et comparaison de la réponse cardiovasculaire aux modulations du SNA pendant la nuit, ainsi qu'en réponse à des manœuvres normalisées, telles que l'épreuve d'effort ou le test d'orthostatisme, chez une série de patients BS présentant différents niveaux de risque (sujets symptomatiques et asymptomatiques). Une première partie du travail de thèse est dédiée à l’application de méthodes d'analyse de complexité cardiaque, de sensibilité baroréflexe et de variabilité non-stationnaire du rythme cardiaque, jamais étudiées dans le cadre des patients BS. Dans une deuxième partie, afin d'aborder la nature multifactorielle de la maladie, une approche multivariée basée sur une méthode de machine learning est introduite. En employant des marqueurs extraits à l'analyse du traitement du signal précédent, des classificateurs robustes capables de distinguer les patients à différents niveaux de risque sont proposés. Dans la troisième partie de ce travail, deux modèles mathématiques de connaissances ont été proposés et analysés, afin d'étudier les réponses autonomiques et hémodynamiques au test d’orthostatisme et à l’épreuve d’effort. Enfin, une application prospective d’une approche multivariée intégrant les paramètres extraits à l'étape de modélisation est également présentée. L’ensemble des résultats de la thèse permet une meilleure caractérisation des profils autonomiques des patients BS et laisse envisager une amélioration de la sélection des patients pour implantation d'un défibrillateur implantable
Brugada syndrome (BS) is a genetic arrhythmogenic disease characterized by a distinctive electrocardiographic pattern, associated with a high risk for sudden cardiac death. Its complex and multifactorial nature turns risk stratification into a major challenge. Although variations in autonomic modulation are commonly related to arrhythmic events in this population, novel markers with higher predictive values are still needed so as to identify those patients at high risk. Since the autonomic function can be better characterized through the application of standardized maneuvers stimulating the autonomic nervous system (ANS), the main objective of this thesis is to evaluate and compare the cardiovascular response to ANS modulations overnight, as well as in response to exercise and HUT testing, on a series of BS patients with different levels of risk (symptomatic and asymptomatic subjects). In a first part of this work, we apply previously described methods for the analysis of heart rate complexity, baroreflex sensitivity, and non-stationary heart rate variability, never before studied in the context of BS patients. In a second part, in order to address the multifactorial nature of the disease, a multivariate approach based on a step-based machine learning method is introduced. By employing markers extracted at signal-processing analysis, robust classifiers capable of distinguishing patients at different levels of risk are proposed. The third part of this work has been focused on the proposal of novel mathematical models and the associated model analysis methods, so as to study the autonomic and hemodynamic responses to exercise and HUT testing. Finally, a prospective application of a multivariate approach integrating parameters extracted at the model-based stage is also presented. Overall, the obtained results provide new insights into the underlying autonomic mechanisms regulating the cardiovascular system in BS, improving physiopathology and prognosis interpretation. The proposed approach may be used as an instrument for the identification of those asymptomatic patients at high risk who may benefit from a cardioverter defibrillator implantation
El síndrome de Brugada (SB) es una enfermedad genética asociada a un patrón electrocardiográfico característico y a un elevado riesgo de muerte súbita cardíaca (MSC), causada por fibrilación ventricular (FV) en ausencia de cardiopatías estructurales. Debido a su naturaleza compleja y multifactorial, la estratificación del riesgo supone, en la actualidad, uno de los aspectos más controvertidos. Ciertas alteraciones en la modulación del sistema nervioso autónomo (SNA) se han relacionado con eventos arrítmicos en esta población; no obstante, nuevos marcadores con valores predictivos más elevados que permitan identificar a aquellos pacientes con un alto riesgo de sufrir MSC son todavía necesarios. El uso de maniobras estandarizadas con el objetivo de estimular el SNA permite una mejor caracterización de la función autonómica. El principal objetivo de esta tesis doctoral es, por tanto, la evaluación exhaustiva de la respuesta cardiovascular a la modulación del SNA en una serie de pacientes con SB y diferentes niveles de riesgo (sujetos sintomáticos y asintomáticos), a través de diferentes maniobras autonómicas, con la finalidad de identificar nuevos marcadores potencialmente útiles para la estratificación de riesgo en esta población. En este contexto, la evaluación de la función autonómica se llevó a cabo mediante tres estrategias principales. En primer lugar, se caracterizaron y compararon la variabilidad y complejidad del ritmo cardíaco, así como la sensibilidad barorrefleja, en pacientes sintomáticos y asintomáticos, con el objetivo de identificar nuevos marcadores capaces de distinguir entre grupos de pacientes. Los resultados mostraron, en el grupo sintomático, una menor variabilidad y complejidad durante la noche, así como un mayor tono vagal y una menor actividad simpática tanto durante el ejercicio como en respuesta a la prueba de mesa inclinada. En un segundo análisis, se abordó la etiología multifactorial del síndrome mediante un enfoque multivariado basado en un método de aprendizaje automático por etapas. A partir de marcadores extraídos en la etapa anterior, se propusieron modelos predictivos capaces de clasificar pacientes diagnosticados con SB en función de su nivel de riesgo. El mejor clasificador (AUC = 95%) fue diseñado a partir de marcadores autonómicos obtenidos durante la noche, superando modelos predictivos previamente descritos para la estratificación del riesgo en el SB a partir de la combinación de parámetros no invasivos. Finalmente, se analizaron las interacciones entre las funciones mecánica, circulatoria y autonómica de estos pacientes a partir de modelos fisiológicos. En primer lugar, mediante la implementación y evaluación de un modelo computacional integrando la dinámica del sistema cardiovascular y su respuesta autonómica a la prueba de mesa inclinada. Asimismo, se propuso la identificación recursiva de un modelo implementado para el análisis de la evolución temporal de las contribuciones simpática y parasimpática del SNA durante una prueba de esfuerzo. Los resultados mostraron una menor contractilidad, así como una actividad parasimpática significativamente mayor durante el ejercicio, en pacientes sintomáticos. Con el objetivo de combinar características extraídas del modelado fisiológico, un último estudio prospectivo propuso el diseño de un clasificador multivariado integrando los parámetros estimados en esta última etapa. Los resultados obtenidos indican importantes tendencias de relevancia clínica que aportan nuevos conocimientos sobre los mecanismos autonómicos encargados de regular el sistema cardiovascular en el SB. Su interpretación permite mejorar la estratificación del riesgo en estos pacientes y, por tanto, optimizar las estrategias terapéuticas aplicadas. La metodología propuesta se presenta como un instrumento para la identificación de aquellos pacientes con alto riesgo de MSC que podrían beneficiarse de la implantación de desfibriladores automáticos
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Zheng, Tao, and 郑涛. "A bio-feedback rehabilitation system for neuromuscular recovery on elbow joint movement." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47045917.

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Deng, Yuwen. "Animated vehicle turning path simulation system on an Internet/Intranet browser." CSUSB ScholarWorks, 2002. https://scholarworks.lib.csusb.edu/etd-project/2091.

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The animated vehicle turning path simulation system on Internet/Intranet web browser presented in this project is intended to provide civil engineers with an easy-to-use, all functional simulation system that could help them with highway and street design.
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夏炯 and Jiong James Xia. "Three-dimensional surgical planning and simulation system for orthognathic surgery in virtual reality environment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B3123950X.

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39

Mitchell, Eric J. (Eric Joseph) 1978. "Simulation of an optical network system for a space based high performance computer system." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/16841.

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Thesis (M.Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2002.
Includes bibliographical references (leaf 57).
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
An important future addition for a Space Based High Performance Computer System is a high-speed optical network for faster data transmission. The purpose of this project is to research and simulate next generation computing applications on high-speed optical networks. The research has been performed in the System Application context involving embedded high-performance computing applications and optical networking technology to guide future research and development of advanced optical devices. The research addresses advanced processing system issues in bandwidth, latency, protocol, topology, and fault tolerance in relation to high performance systems. The reference distributed computer, provided by BAE SYSTEMS in Nashua New Hampshire, consists of multiple processing nodes connected by a Myrinet copper network. The advanced embedded computing applications include Space-Based Radar Corner Turn processing, Synthetic Aperture Radar Back End processing, and Random Workload software models. Two Optical networks have been developed as part of this research to replace the reference Myrinet network, a Ring based network and a Star based network. Both networks employ redundancy to provide an alternate direct optical path between each pair of nodes. Of these networks the Ring design failed due to packet collisions and due to the need for a complex networking protocol. The Star Optical network design performed well in comparison to the reference network design. Overall, network latency was reduced and the internode data distribution speed was dramatically increased. Also, the memory usage for each of the three software models was analyzed and each has definite bound that will help future development. Although the results of this research are favorable, the eventual future design and implementation of a Space Based High Performance Computer System would benefit from additional research on a number of topics.
by Eric J. Mitchell.
M.Eng.
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Limsäter, Fredrik. "REACT - Crowd Simulation System for Visual Effects." Thesis, Linköping University, Department of Science and Technology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-4737.

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By using existing knowledge from the game community, which have had a long experience from game artificial intelligence, and new research

from the field of artificial intelligence I have implemented REACT, a crowd simulation system for visual effects. REACT is based on high-level behaviour that uses an underlying layer of low-level behaviour. The high-level capabilities gives the digital character means to reasoning about how to achieve certain goals based on a knowledge base of rules and facts that are present in the virtual world. This gives the digital character a degree of autonomous intelligent behaviour.

REACT is designed to integrate directly into the 3D animation package Maya as a plug-in. This means that the animators can continue to animate their characters via their animation package of choice, rather than having to learn a new technology. In addition, many animators are already familiar with the workflow of Maya, so learning curves are reduced.

REACT is already in use in the visual effects industry where it has proven itself to be a worthy competitor to the existing systems on the market.

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Runåker, Björn. "Distributed system simulation with host-based target offloading." Thesis, KTH, Skolan för datavetenskap och kommunikation (CSC), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-165177.

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Scaling of TLM (Transaction Level Modeling) simulations for performance is difficult. In this project I will go through several causes of poor performance. This paper describes several simulation engines that use SystemC that are connected so they together simulate next generation radio base station. It also describes how to build a virtual network in, for security reasons, constrained environment where both virtual and physical equipment can connect the simulated target. Furthermore, it describes how to use the virtual network to improve the overall performance of the simulation. It is shown how the virtual network is used to distribute the simulation and offloading the simulated target to accomplish the performance goal.
Det är svårt att skala upp en simulering baserad på TLM (Transaction Level Modeling). I detta projekt kommer jag att gå igenom flera orsaker till dålig prestanda. Denna rapport beskriver flera olika simuleringsmotorer som använder SystemC och som är kopplade så att de tillsammans simulerar nästa generation radiobasstationer. Här beskrivs också hur man bygger ett virtuellt nätverk som hanterar begränsningar som finns av säkerhetsskäl, och trots detta kan koppla ihop virtuell och fysisk utrustning till det simulerade målsystemet. Dessutom anges hur detta virtuella nät används för att förbättra den övergripande prestandan i simuleringen. Detta görs genom att utnyttja det virtuella nätet för att distribuera simuleringen och avlasta målsystemet.
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Nóbrega, Rui Pedro da Silva. "Visualization and interaction in a simulation system for flood emergencies." Master's thesis, Faculdade de Ciências e Tecnologia, 2008. http://hdl.handle.net/10362/7830.

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Dissertação apresentada na Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa para obtenção do grau de Mestre em Engenharia Informática
This thesis presents an interaction and visualization system for a river flood emergency simulation. It will also present a detailed study about forms of visual representation of critical elements in emergencies. All these elements are currently assembled in an application based on geographic information systems and agent simulation. Many of the goals in this thesis are interconnected with project Life-Saver. This project has the goal to develop an emergency response simulator, which needs a visualization and interaction system. The main goals of this thesis are, to create a visualization system for an emergency, to design an intuitive multimedia interface and to implement new forms of human-computer interaction. At the application level there is a representation of the simulation scenario with the multiple agent and their actions. Several studies were made to create an intuitive interface. New forms of multimedia interaction are studied and used such as interactive touch sensible boards and multi-touch panels. It is possible to load and retrieve geographic information on the scenario. The resulting architecture is used to visualize a simulation of an emergency flooding situation in a scenario where the Alqueva dam in Guadiana river fails.
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Cristaldo, Nelson. "Secure power grid infrastructure simulation and test-bed system creation." FIU Digital Commons, 2007. http://digitalcommons.fiu.edu/etd/2668.

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This thesis describes the design and construction of the test-bed system as well as its implementation to simulate the distributed control scheme. Some important elements of the system incorporate flexible power system network hardware and a data acquisition (DAQ) system to evaluate the issues that could trigger cascaded failures. The objective of this research was to create an integrated simulation environment that represents the power system devices, the control, the protection, and the communication subsystems in the same simulation environment. We have utilized this simulator to conduct system studies and evaluate the interaction between power system components under steady-state and transient operation. The results of these studies have been used to enhance the system's ability to identify, and respond to the system's dynamic transients; improving the survivability and robustness of the power system during and after a disturbance by utilizing distributed control strategies. Experiments demonstrated in this thesis show the applicability of the developed simulator to conduct system studies and to evaluate the proposed distributed control infrastructure. The results show the advantages of utilizing distributed control and the impact in the system security and reliability.
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Heijmans, Franciscus R. C. "A computer simulation of the pulmonary microvascular exchange system - alveolar flooding." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/25099.

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Previous models of the pulmonary microvascular exchange system (28,29) have been restricted to the study of fluid and solute exchange between the pulmonary microcirculation, interstitial tissue space, and lymphatics. In severe pulmonary edema the capacities of the lymphatics and tissue space are exceeded. The fluid and solutes entering the interstitium from the circulation will, then, be transported Into the air space. The accumulation of fluid in the air space impairs the diffusion of gas (oxygen and carbon dioxide) between the air space and blood circulation; if this fluid accumulation is excessive a patient's health may be compromised. In this thesis severe pulmonary edema is studied by including the air space as a fourth compartment into the interstitial model developed by Bert and Pinder (29). A computer simulation of the four compartment (alveolar) model was developed on a digital computer. Tests of the model were made to study the effect of the parameters which were introduced into the alveolar model. These parameters include: a filtration coefficient that describes the alveolar membrane fluid conductivity, an extravascular fluid volume that represents the point at which fluid enters the air space, the alveolar fluid pressure at the onset of fluid flow into the air space, and the rate of alveolar fluid pressure change relative to an alveolar fluid volume change. For each case the dynamic response of the exchange system was recorded. In addition, two types of pulmonary edema were simulated: 1) hydrostatically induced edema, and 2) edema induced by changes to the fluid and solute permeability of the porous membrane separating the circulatory and interstitial compartments. Due to the limited data available on the interaction of the air space with the other three compartments of the pulmonary microvascular exchange system, only partial verification of the appropriate range of values of the alveolar model parameters and the predictions of the simulations was possible. The alveolar model developed in this thesis is an initial approximation but appears to provide a satisfactory approach for the inclusion of the air space in the pulmonary microvascular exchange system.
Applied Science, Faculty of
Chemical and Biological Engineering, Department of
Graduate
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45

Zheng, Jianzhou, and 鄭建周. "Computer simulation of Maxwell demon and Feynman's ratchet and pawl system." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841690.

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46

Zheng, Jianzhou. "Computer simulation of Maxwell demon and Feynman's ratchet and pawl system." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841690.

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47

Harley, Linda Rosemary. "The application of a knowledge based system to micro-electrode guided neurosurgery." Thesis, Available online, Georgia Institute of Technology, 2004, 2004. http://etd.gatech.edu/theses/available/etd-02042004-131540/unrestricted/harley%5Flinda%5Fr%5F200405%5Fms.pdf.

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Thesis (M. S.)--Civil and Environmental Engineering, Georgia Institute of Technology, 2004.
Dr. Michael Hunter, Committee Member ; Dr. Alexander M. Puzrin, Committee Member ; Dr. Nelson Baker, Committee Chair. Includes bibliographical references.
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Berrada, Meryem. "DCMS: A Data Analytics and Management System for Molecular Simulation." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5453.

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Despite the fact that Molecular Simulation systems represent a major research tool in multiple scientific and engineering fields, there is still a lack of systems for effective data management and fast data retrieval and processing. This is mainly due to the nature of MS which generate a very large amount of data - a system usually encompass millions of data information, and one query usually runs for tens of thousands of time frames. For this purpose, we designed and developed a new application, DCMS (A data Analytics and Management System for molecular Simulation), that intends to speed up the process of new discovery in the medical/physics fields. DCMS stores simulation data in a database; and provides users with a user-friendly interface to upload, retrieve, query, and analyze MS data without having to deal with any raw data. In addition, we also created a new indexing scheme, the Time-Parameterized Spatial (TPS) tree, to accelerate query processing through indexes that take advantage of the locality relationships between atoms. The tree was implemented directly inside the PostgreSQL kernel, on top of the SP-GiST platform. Along with this new tree, two new data types were also defined, as well as new algorithms for five data points' retrieval queries.
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Sullivan, Daniel Thomas. "Computer simulation studies of two-dimensional beamforming for linear arrays using a parallel computer system." Thesis, Monterey, California. Naval Postgraduate School, 1992. http://hdl.handle.net/10945/26426.

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Approved for public release; distribution is unlimited
Computer simulation results of a parallel system conducting beamforming for a linear hydrophone array are presented. These studies were performed to determine the best mapping and partitioning of a sequential beamformer program onto a parallel system. Different partition designs and programming methodologies were examined, as well as latencies caused by inter-processor communications. Results of these simulation studies demonstrate that linear scalability in performance is possible by programming with host-node methodology and utilizing efficient inter-processor communications.
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Koppe, Jason. "Differential virtualization for large-scale system modeling /." Online version of thesis, 2008. http://hdl.handle.net/1850/7543.

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