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Austin, Bruce. "Maxillary Nerve Block Anaesthesia." Thesis, Faculty of Dentistry, 1987. http://hdl.handle.net/2123/5103.
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San, Juan Bernardo G. 1977. "Measuring humeral head translation after suprascapular nerve block." Thesis, University of Oregon, 2009. http://hdl.handle.net/1794/10325.
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xiii, 79 p. : ill. A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number.Subacromial impingement syndrome is the most common disorder of the shoulder. Abnormal superior translation of the humeral head is believed to be one of the major causes of this pathology. The overall purpose of this study was to better understand glenohumeral kinematics in normal healthy individuals using fluoroscopy to help comprehend the mechanism of shoulder impingement. This research was divided into three sections: a validation study to measure humeral head translation, a comparison between dynamic and static arm elevation and lastly, humeral head translation after a suprascapular nerve block. In the first study, fluoroscopy was used to take images of human cadaver shoulders. Scapular orientation was manipulated in different positions while the humerus was at 90 degrees of elevation. Humeral head translation was measured using two methods and was compared to the known translation. Additionally, the accuracy of the contour registration method to measure 2-D scapular rotations was assessed. For the second study, subjects elevated their dominant arm while fluoroscopic images were taken. An edge detection software was utilized to digitize points on both the humeral head and glenoid. Humeral head translation and scapular upward rotation were measured using a contour registration method with respect to the glenoid during arm elevation. Five different arm elevation angles were investigated to measure differences in humeral head translation between trials. There was no difference found between humeral head translation and scapular upward rotation between static and dynamic shoulder elevation. For the third study, humeral head translation was measured before and after a suprascapular never block. The humeral head was superiorly located and the scapula was more upwardly rotated after the block. The differences were observed during mid range of motion. This result showed that there was a compensatory increase in both humeral head translation and scapular upward rotation due to the nerve block. These results suggest that increasing muscular strength and endurance of the supraspinatus and infraspinatus muscle could prevent any increased superior humeral head translation. This may be beneficial in preventing shoulder impingement or rotator cuff tear over time. This dissertation includes unpublished co-authored materials.
Committee in charge: Andrew Karduna, Chairperson, Human Physiology; Li-Shan Chou, Member, Human Physiology; Louis Osternig, Member, Human Physiology; Stephen Frost, Outside Member, Anthropology
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Joseph, Laveeta. "Conduction block in peripheral nerves: effect of high frequency stimulation on different fiber types." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/42723.
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Selective stimulation and conduction block of specific nerve fibers has been a major area of research in neuroscience. The potential clinical and neurophysiological applications have warranted reliable techniques for transiently blocking conduction through nerves. High Frequency Alternating Current (HFAC) waveforms have been found to induce a reversible and repeatable block in peripheral nerves; however the effect of these waveforms on the neural activity of individual fiber types is currently unknown. Understanding this effect is critical if clinical applications are to be pursued. This dissertation work utilized extracellular electrophysiological techniques to characterize the activity of different fiber type populations in peripheral nerves during application of HFAC waveforms. First, we investigated the phenomenon in the homogeneous unmyelinated nerves of the sea-slug, Aplysia californica. Although complete reversible block was demonstrated in these nerves, a non-monotonic relationship of block threshold to frequency was found which differed from previously published work in the field. We then investigated the effect of HFAC waveforms on amphibian mixed nerves and studied the response of specific fiber types by isolating different components of the compound action potential. We validated our results from the Aplysia nerves by determining the block thresholds of the larger diameter, myelinated A-fibers and comparing them with those of the smaller diameter, unmyelinated C-fibers. We also showed that block threshold behavior during application of the HFAC waveform depends on the nerve fiber type, and this property can be used to selectively block specific fiber types. Finally, we examined the recovery time after block induction in unmyelinated nerves and found that recovery from block was dependent on the duration of application of the HFAC waveform. The time-dependent distribution of the recovery time and the non-monotonic threshold behavior in the smaller diameter unmyelinated nerves indicate that multiple mechanisms are involved in block induction using HFAC waveforms, and these mechanisms are dependent not only on the blocking stimulus but also on the characteristics of the nerve fiber. Overall, this work demonstrates that HFAC waveforms may enable inherent peripheral nerve properties to be exploited for potential clinical applications related to the treatment of unwanted neural activity.
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Kozinn, Rachel. "Adductor Canal Nerve Block to Improve Total Knee Arthroplasty Recovery." Thesis, The University of Arizona, 2018. http://hdl.handle.net/10150/626858.
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Brock, Shelly M. "Paravertebral Nerve Block for Pain Management of Nissen Fundoplication Surgery." UNF Digital Commons, 2004. http://digitalcommons.unf.edu/etd/147.
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Providing comfort is a fundamental nursing responsibility. Unrelieved postoperative pain has adverse physiologic and psychologic effects that contribute to prolonged hospital admissions and significant discomfort to patients. Opioids are standard methods of postoperative analgesia for many surgical procedures. Unfortunately, the use of opioids is associated with side effects such as nausea and vomiting, urinary retention, ileus and respiratory depression. These side effects, with the added problem of inadequate pain control, result in patient dissatisfaction with surgical procedures.
Paravertebral nerve block (PVB) is a regional anesthetic technique that has been shown to result in opioid sparing in many procedures including breast and hernia surgery. This study investigated the possibility of improved postoperative pain and nausea management when combining paravertebral nerve blocks with general anesthesia (GA) , compared to general anesthesia alone, for laparoscopic Nissen fundoplication surgery. The convenience sample consisted of 29 patients receiving surgery at the Mayo Clinic, Jacksonville, Florida. There was significant correlation between the type of anesthesia and pain at 12 hours postoperatively, indicating that those who received PVB had less pain than those receiving GA alone, at that time. Although there was no significant correlation between type of anesthesia and nausea, only one patient vomited and others had minimum to moderate nausea, postoperatively. The information attained from this research will be beneficial to nurses providing pain management for patient comfort in the outpatient surgery center.
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Ackermann, Douglas Michael Jr. "REDUCTION OF THE ONSET RESPONSE IN HIGH FREQUENCY NERVE BLOCK." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1259791396.
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Vrabec, Tina L. "Direct Current Block of Peripheral Nerve: Electrode and Waveform Development." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1448989101.
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Moriyama, Akio, Harutoshi Sugiyama, Takara Tajima, and Hiroyuki Nitta. "Study on Dermatomes by Means of Selective Lumbar Spinal Nerve Block." Thesis, Lippincott Williams & Wilkins, 1993. http://hdl.handle.net/2237/16723.
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Franke, Manfred. "Translating Electric KHFAC and DC Nerve Block from Research to Application." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1397006454.
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Glosenger, Jeremiah J. "Preliminary Comparison of Missed Blocks with 4% Articaine and 2% Lidocaine both with 1:100,000 epinephrine on Inferior Alveolar Nerve Block Injections." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1305927125.
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Nagle, Shandelle. "Predicting who will respond to nerve block therapy. Is neuroticism a factor?" Thesis, Nagle, Shandelle (2004) Predicting who will respond to nerve block therapy. Is neuroticism a factor? Masters by Coursework thesis, Murdoch University, 2004. https://researchrepository.murdoch.edu.au/id/eprint/56671/.
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The aim of the current research was to determine whether psychosocial variables predicted who would respond to nerve block treatment in 33 adults (11 males and 22 females) ranging from 20 to 79 years of age. Participants completed the NEO PI-R, General Health Questionnaire, Roland Morris Disability Questionnaire and Pain experience Visual Analogue Scales before and after nerve block treatment. Regression analysis indicated age was the only variable to predict response to nerve block therapy. Results showed neuroticism did not influence change in pain scores but did influence the affective stages of pain processing. Those responding to treatment reported reductions in pain, emotional and psychological distress and increased activities of daily living.
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Huang, Frank. "The Gow-Gates mandibular block : anatomical considerations in adults and a clinical comparison with the inferior alveolar nerve block /." Title page, contents, preface and introduction only, 2000. http://web4.library.adelaide.edu.au/theses/09SB/09sbh874.pdf.
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Kieselbach, Rebecca. "A numerically stable model for simulating high frequency conduction block in nerve fiber." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41233.
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Previous studies performed on myelinated nerve fibers have shown that a high frequency alternating current stimulus can block impulse conduction. The current threshold at which block occurs increases as the blocking frequency increases. Cable models based on the Hodgkin-Huxley model are consistent with these results.
Recent experimental studies on unmyelinated nerve have shown that at higher frequencies, the block threshold decreases. When the block threshold is plotted as a function of frequency the resulting graph is distinctly nonmonotonic. Currently, all published models do not explain this behavior and the physiological mechanisms that create it are unknown. This difference in myelinated vs. unmyelinated block thresholds at high frequencies could have numerous clinical applications, such as chronic pain management.
A large body of literature has shown that the specific capacitance of biological tissue decreases at frequencies in the kHz range or higher. Prior research has shown that introducing a frequency-dependent capacitance (FDC) to the Hodgkin-Huxley model will attenuate the block threshold at higher frequencies, but not to the extent that was seen in the experiments. This model was limited by the methods used to solve its higher order partial differential equation. The purpose of this thesis project is to develop a numerically stable method of incorporating the FDC into the model and to examine its effect on block threshold. The final, modified model will also be compared to the original model to ensure that the fundamental characteristics of action potential propagation remain unchanged.
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Narasimhan, Anirudhan. "Commercialization of HFAC Electronic Nerve Block Technology to Treat Chronic Post Surgical Pain." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1290641992.
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Droll, Brock A. "Local Anesthetic Efficacy of the Inferior Alveolar Nerve Block in Red-haired Females." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1316623943.
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Weinstein, Sara Margit Abbott. "Extra-oral Mandibular Nerve Block Comparative Evaluation of Local Anesthetic Distribution Using Ultrasonography." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1395252383.
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Foley, Jessica Lynne. "High-intensity focused ultrasound as a novel method of nerve conduction block : dose-dependent effects range from partial to complete block /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/7981.
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Van, der Walt Sone. "The anatomy of the pudendal nerve and its branches and the clinical implications thereof." Diss., University of Pretoria, 2013. http://hdl.handle.net/2263/40701.
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Knowledge of the course of the pudendal nerve (PN) is important when performing perineal surgery. Distances between landmarks were measured after PN dissections in 71 cadavers and after perineal procedures on 30 cadavers. Separate inferior rectal nerve (IRN) entry and medial position of the PN/IRN with shortened sacrospinous ligaments were often seen in black individuals. A PN block should therefore be placed more proximally and medially. The Richter’s stitch should be placed further from the ischial spine. During ischioanal procedures the IRN is at risk in white females, as it was more superficial. The dorsal nerve of the clitoris/penis (DNC/DNP) is in danger during the outside-in procedures in white or obese individuals, as it was closer to the inferior pubic ramus. The dorsal penile nerve block should be administered deeper in white and obese individuals, as the DNP was deeper. The above-mentioned findings should be verified in a clinical setting.Dissertation (MSc)--University of Pretoria, 2013.
gm2014
Anatomy
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Crowley, Chase Elliott. "Anesthetic Efficacy of an Upright Versus a Supine Position for Inferior Alveolar Nerve Block." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1470051706.
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Boger, Adam Sprott. "Application of High Frequency Electrical Block on the Efferent Nerves to the Lower Urinary Tract for Bladder Voiding." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1238788042.
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Silberstein, Guy. "An Investigation Into The Desirable Level Of Injection For Mandibular Anaesthesia By Comparison Of The Conventional Technique And A Higher Level Technique Utilising Extra-Oral Landmarks." Thesis, The University of Sydney, 1993. http://hdl.handle.net/2123/4853.
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Van, Schoor Albert-Neels. "Paediatric regional anaesthetic procedures clinical anatomy competence, pitfalls and complications /." Pretoria : [s.n.], 2004. http://upetd.up.ac.za/thesis/available/etd07062005-151955.
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Furstein, James. "Sciatic Peripheral Nerve Blockade for Pain Control Following Hamstring Autograft Harvest in Adolescents: A Comparison of Two Techniques." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4165.
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Anterior cruciate ligament reconstruction utilizing a hamstring autograft is a surgical technique that has gained popularity among orthopedic surgeons caring for adolescent patients. While utilization of a hamstring autograft is a revered technique, harvest of the hamstring yields significant pain. Sciatic peripheral nerve blockade has proven to reliably provide analgesia at the hamstring donor site. Single-injection sciatic peripheral nerve blockade is considered a basic and effective technique, making its use following anterior cruciate ligament reconstruction standard practice in many institutions. The duration of action of a single-injection sciatic peripheral nerve blockade may fail to outlast the pain arising from the hamstring donor site, prompting some clinicians to employ continuous sciatic peripheral nerve blockade via an indwelling catheter. A lack of comparative effectiveness studies exists in the literature regarding the duration of action of peripheral nerve blockade necessary to adequately provide pain control following hamstring autograft harvest, resulting in disagreement among clinicians as to best pain control practices. Proponents of continuous sciatic peripheral nerve blockade assert that while more costly, the extended duration of analgesia afforded by this technique improves pain control postoperatively and decreases the use of other pain medications. Advocates of single-injection sciatic peripheral nerve blockade cite concerns associated with continuous sciatic peripheral nerve blockade known to be detrimental to rehabilitation, such as decreased active knee flexion and increased risk of falls. The purpose of this research is to compare the effect of single-injection sciatic PNB to continuous sciatic PNB on 1) postoperative pain control as measured by self-reported pain scores, pain medication use, and unplanned hospital admission due to poor pain control, 2) active knee flexion, and 3) patient satisfaction with pain control following ACL reconstruction with a hamstring autograft. The findings of this study have the potential to guide informed clinical reasoning and decision making regarding sciatic peripheral nerve blockade techniques following hamstring autograft harvest in adolescents undergoing anterior cruciate ligament reconstruction.
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Lukošienė, Laura. "Tarpšonkaulinių nervų blokados efektyvumo tyrimas vaikams, kuriems atliekamos minimaliai invazinės įdubusios krūtinės korekcijos operacijos." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2015. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2014~D_20150106_083725-00355.
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Įgimtos krūtinės sienos deformacijos, kurių korekcijai reikalingas chirurginis gydymas apima visa spektrą skeleto raumenų sistemos morfologinių sutrikimų. Didžiausią dalį šių deformacijų sudaro įdubusi krūtinė. Nors daugiau nei du dešimtmečius chirurginė korekcija atliekama taikant minimaliai invazinę metodiką, optimaliausias ankstyvojo pooperacinio skausmo malšinimo metodas yra aktyvių diskusijų objektas mokslinėje literatūroje. Disertacijos tikslas – ištirti regioninio skausmo malšinimo metodikos – tarpšonkaulinių nervų blokados (TNB) efektyvumą vaikams, kuriems atliekamos įdubusios krūtinės korekcijos operacijos minimaliai invaziniu metodu. Disertacinis darbas atliktas taikant dvigubai aklą, atsitiktinių imčių tyrimo metodiką. Toks tyrimas yra vienintelis TNB efektyvumo mokslinis tyrimas vaikams, kuriems atliekama minimaliai invazinė įdubusios krūtinės chirurginė korekcija. Tyrimo rezultatai parodė, kad TNB yra efektyvus multimodalinio skausmo malšinimo komponentas, nulėmęs kokybiškesnį skausmo malšinimą, mažesnį opioidų sunaudojimą, mažesnį opioidų šalutinio poveikio dažnį ir aukštesnį pasitenkinimą pooperaciniu laikotarpiu.Pain management in pediatric patients undergoing the minimally invasive repair of pectus excavatum (MIRPE) continues to be a challenge and is currently debated in the literature. Pain management strategies have included systemic opioids via patient-controlled analgesia, non-steroidal anti-inflammatory drugs and regional analgesia. Although studies have demonstrated that modern pain management strategies are adequate, the optimal technique has yet to be clearly determined. The aim of this study was to investigate the efficacy of a single shot bilateral intercostal block (IB) for pain control in pediatric patients undergoing the MIRPE. The study was conducted in a double-blind, randomized manner. This study is the first and the only study describing efficacy of bilateral IB in pediatric patients undergoing MIPRE. Study showed that the IB with local anesthetic group demonstrated improved quality of pain relief, reduced intraoperative and postoperative opioid consumption, less side effects associated with opioid consumption in the early postoperative period and improved level of satisfaction with the effectiveness of pain management and overall postoperative period.
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Siviero, Marcelo. "Comparação da articaína e lidocaína no bloqueio do nervo alveolar inferior." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-09042009-123619/.
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O objetivo dessa pesquisa foi avaliar o tempo de latência e duração pulpar anestésica da dose de 1,8ml das seguintes soluções anestésicas locais: cloridrato de articaína 4% associado à epinefrina 1:100.000 (ART 100) e 1:200.000 (ART 200) e cloridrato de lidocaína 2% associado à epinefrina 1:100.000 (LIDO 100) no bloqueio convencional do nervo alveolar inferior. A amostra do experimento consistiu de vinte pacientes normorreativos, submetidos a três consultas para tratamento restaurador de baixa complexidade em três dentes posteriores inferiores. Os períodos de latência e duração da anestesia local na polpa dentária foram monitorados com um estimulador pulpar elétrico (Vitality Scanner Model 2006®-SybronEndo, CA, EUA). Para análise e comparação dos resultados da latência e duração pulpar das três soluções anestésicas locais foi utilizado o teste paramétrico ANOVA e o teste auxiliar de Bonferroni com nível de significância fixado em 5% (p<0,05). Em relação ao período de latência pulpar não houve diferença estatisticamente significante entre nenhuma das três soluções anestésicas locais utilizadas (p > 0,05). Já em relação ao período de duração pulpar houve diferença estatisticamente significante entre ART 100 e LIDO 100 (p=0,000) e entre ART 200 e LIDO 100 (p=0,000). Portanto, a latência das duas soluções de articaína foram similares à solução de lidocaína, mas ambas apresentaram duração de ação anestésica maior do que a solução de lidocaína.The aim of this study was to evaluate the time of onset and duration of pulp anesthetic dose of 1.8 ml of local anesthetic solutions following: 4% hydrochloride articaine associated with epinephrine 1:100.000 (ART 100) and 1:200.000 (ART 200) and 2% hydrochloride of lidocaine associated with epinephrine 1:100.000 (LIDO 100) in alveolar nerve block lower. The sample of the experiment consisted of twenty healthy patients, underwent three appointments for restorative treatment of low complexity in three subsequent lower teeth. The periods of onset and duration of local anesthetic in dental pulp were monitored with an electric stimulator pulp (Vitality Scanner®, Model 2006 - SybronEndo, CA, USA). To analyze and compare the results of onset and duration of the three pulp solutions local anesthetic was used parametric ANOVA test and the test of Bonferroni help with significance level set at 5% (p < 0.05). For the period of onset there was no statistically significant difference between any of the three approaches used local anesthetic (p> 0.05). Already in relation to the duration of pulp statistically significant difference between ART 100 and LIDO 100 (p = 0000) and between ART 200 and LIDO 100 (p = 0000). Therefore, the onset of the two solutions of articaine were similar to the solution of lidocaine, but both showed duration of anesthetic action superior to the solution of lidocaine.
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Touzot-Jourde, Gwenola. "Injections péri-neurales écho-guidées du rameau ventral du 7ème et 8ème nerf spinal cervical chez le cheval sain : étude anatomique post-mortem et évaluation clinique de l’anesthésie tronculaire." Thesis, Nantes, Ecole nationale vétérinaire, 2018. http://www.theses.fr/2018ONIR106F/document.
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La radiculopathie cervicale caudale a été identifiée comme cause de boiterie affectant le membre antérieur chez le cheval. Les affections dégénératives des articulations intervertébrales des processus articulaires entraînent un remodelage périarticulaire pouvant comprimer les racines du nerf spinal ou leur rameau ventral. Les objectifs de l’étude étaient de décrire la réalisation d’injections échoguidées périneurales du rameau ventral des nerfs spinaux cervicaux 7 et 8 (RV7 et RV8), d’évaluer sur des cadavres de chevaux par dissection la diffusion péri-nerveuse d’une solution colorée ainsi que de décrire chez des chevaux sains les signes cliniques associés à une anesthésie périneurale échoguidée du RV7 et RV8 individuellement. Dans l’étude post-mortem, 5 RV7 et 5 RV8 ont été visualisés échographiquement et colorés par une injection de 7 ou 14 ml de solution colorée. Une portion du tronc nerveux a été trouvée coloré pour chaque injection. La coloration était uniforme transversalement sur toute la largeur du nerf et couvrait une longueur supérieure à 2 cm pour 8 RV alors qu’une coloration de la moitié crâniale du RV sur une longueur de moins de 2 cm pour un RV7 et un RV8. L’étude sur cheval sain portait sur 4 chevaux sains sans image radiographique anormale de la colonne cervicale. Six RV7 et 8 RV8 ont été anesthésiés de la Lidocaïne 2% mélangés à du iohexol. Toutes les injections ont entraîné boiterie antérieure ipsilatérale de l’injection. Les boiteries les plus sévères correspondaient à une parésie du nerf suprascapulaire pour RV7 et à une parésie radiale pour RV8. Cette étude a montré qu’il était possible de réaliser une injection périneurale des RV 7 et RV8 chez le cheval et que l’anesthésie tronculaire des deux racines provoque une atteinte motrice essentiellement de la fonction nerveuse. Ces résultats contribuent à mieux comprendre la symptomatologie des compressions nerveuses cervicales chez le chevalCaudal cervical radiculopathy has been identified as a cause of frontlimb lameness in horses. Degenerative conditions of articular process joint result in periarticular remodeling responsible for compression of spinal nerve roots or their ramus ventralis (RV). The objectives of the study were to describe how to perform perineural RV injection under ultrasonographic guidance, to evaluate on cadaver perineural RV staining after a dye solution injection, as well as describe clinical signs associated with a perineural ultranosonography-guided anesthesia of RV7 and RV8 respectively. In the post-mortem study, the RV of the spinal cervical nerves was visualized in all cadavers. Eight RV had a uniform transversal staining of the nerve trunk that covered longitudinally a distance greater than 2 cm. One C7 and one C8 RV showed incomplete transversal staining with a more concentrated color on its half cranial aspect and a longitudinal coverage of less than 2 cm. The in vivo study included 6 RV7 and 8 RV8 perineural injections of a local anesthetic agent, performed on 4 horses that had no abnormal finding on cervical radiographs. All anesthetic injections (lidocaine 2% and iohexol) resulted in modifications of the locomotion with variable degree of lameness on the ipsilateral frontlimb. Severe lameness was characteristic of a suprascapular paresis for RV7 and a radial paresis for RV8. Mild to moderate lameness on the ipsilateral frontlimb included decreased anterior phase of the stride, intern circumduction of the limb and sometimes stumbling for that same frontlimb. Signs of ataxia on the hindlimbs were encountered for 3 injections. This study showed that it is possible to perform perineural injections of RV7 and RV8 in horses and that perineural anesthesia of RV7 and RV8 results in motor dysfunction. These findings constitute a contribution to understanding clinical signs associated with cervical nerve compression in horses
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Oleson, Mark L. "The effect of preoperative ibuprofen on the efficacy of the inferior alveolar nerve block in patients with irreversible pulpitis." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1251377516.
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Schellenberg, Jared John. "THE EFFECT OF BUFFERED LIDOCAINE ON THE SUCCESS OF THE INFERIOR ALVEOLAR NERVE BLOCK IN PATIENTS WITH IRREVERSIBLE PULPITIS." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405078282.
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Schiavi, Susan C. "MYC and E1A Oncogenes Alter the Response of PC12 Cells to Nerve Growth Factor and Block Differentiation: A Thesis." eScholarship@UMMS, 1988. https://escholarship.umassmed.edu/gsbs_diss/259.
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PC12 rat pheochromocytoma cells respond to nerve growth factor (NGF) by neuronal differentiation and partial growth arrest. Mouse c-myc and adenovirus E1A genes were introduced into PC12 cells to study the influence of these nuclear oncogenes on neuronal differentiation. Expression of myc and E1A blocked morphological differentiation and caused NGF to stimulate rather than inhibit cell proliferation. NGF binding to cell surface receptors, activation of ribosomal S6 kinase, and ornithine decarboxylase induction were similar in myc and E1A expressing clones compared with wild-type PC12 cells, suggesting that changes in the cellular response to NGF were at a post-receptor level. The ability of myc and E1A expression to block the transcription-dependent induction of microtubule associated proteins by NGF further suggested that these genes may inhibit differentiation by interfering with NGP's ability to regulate transcription. These results illustrate that NGF can promote either growth or differentiation of PC12 cells, and that myc or E1A alter the phenotypic responses to growth factors.
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Chan, Ee Yuee. "Acute Pain Management after Total Knee Arthroplasty." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/9906.
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Acute Pain Management after Total Knee Arthroplasty Abstract This thesis presents a body of work aimed at improving the acute pain management of patients after total knee arthroplasty (TKA). A randomized controlled trial (RCT) of 200 patients found that significant knee pain on movement 24 hours after surgery was reduced with single-injection (OR 0.30; 95% CI 0.12 to 0.74) or continuous (OR 0.21; 95% CI 0.08 to 0.51) femoral nerve block (FNB), compared with patient-controlled analgesia (PCA) opioid. Also, FNB required less opioid compared to PCA. There were no significant differences in ‘timed up and go’ between the three analgesic groups at all time-points. There was also no significant between group differences in the six-minute walk distance knee flexion range of motion, day achieved independent walking and self-reported physical function. A Cochrane systematic review pooling RCTs evaluating FNB with non-FNB included 45 eligible RCTs (2710 patients). Meta-analyses demonstrated that FNB resulted in less pain at rest and on movement during the first 72 hours after surgery compared to PCA opioid. At 24 hours, pain at rest was SMD -0.72 (95% CI -0.93 to -0.51), while pain on movement was SMD -0.94 (95% CI -1.32 to -0.55). Additionally, FNB provided similar analgesia compared with epidural or local infiltration analgesia, and continuous FNB provided better analgesia than single-injection FNB. A patient survey conducted in Singapore (N = 105) and replicated in Australia (N=171) revealed suboptimal management of acute pain after hospital discharge. Many patients experienced moderate to severe pain and had misperceptions on analgesia. Marked differences in pain experience, behaviors and perceptions of analgesics also existed between the two cohorts. Overall, the thesis provided evidence to guide the choice of postoperative analgesia after TKA. It also highlighted potential areas for improving pain management following hospital discharge and the need for culturally appropriate pain management strategies.
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Cook, Olivia B. DMD. "Anesthetic Efficacy Of 4% Prilocaine Plus 2% Lidocaine With 1:100,000 Epinephrine For Inferior Alveolar Nerve Blocks." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu149945067803552.
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Stanley, William D. "The effect of nitrous oxide on the efficacy of the inferior alveolar nerve block in patients with symptomatic irreversible pulpitis." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1314038784.
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Simpson, Michael G. "The Effect of Preoperative Ibuprofen and Acetaminophen on the Efficacy of the Inferior Alveolar Nerve Block in Patients with Irreversible Pulpitis." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1283382898.
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Fullmer, Spencer C. "The Effect of Preoperative Acetaminophen/Hydrocodone on the Efficacy of the Inferior Alveolar Nerve Block In Patients With Sypmtomatic Irreversible Pulpitis." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1344539002.
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Sousa, Ângela Maria. "Efeito analgésico periférico do tramadol em ratos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5152/tde-11052010-131407/.
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INTRODUÇÃO: O tramadol é um fármaco de ação central e periférica, comercializado como uma mistura racêmica de dois enantiômeros (+) e (-)- tramadol e eficaz no tratamento da dor moderada a intensa. Possui efeito agonista opióide dez vezes menos potente que a codeína. Após o metabolismo de primeira passagem, o tramadol é metabolizado em diversos compostos e seus principais metabólitos, (+) e (-)-O-dimetil-tramadol (M1), são terapeuticamente ativos como analgésicos e possuem afinidade por receptores opióides semelhante à codeína. O tramadol reduz o pico de amplitude de potenciais de ação do nervo ciático isolado e é utilizado como adjuvante à lidocaína no bloqueio do plexo braquial em humanos. MÉTODOS: ratos machos, da linhagem Wistar , 5 a 6 por grupo foram incluídos nos experimentos. Dois modelos animais de hiperalgesia foram estudados : comportamento de elevação da pata induzida por formalina e hiperalgesia mecânica após incisão plantar. Tramadol por via sistêmica e intraplantar foi utilizado nos dois modelos e foi realizado bloqueio do nervo ciático com tramadol após a localização deste com estimulador de nervo periférico. O antagonista dos receptores de opióides, naloxona, foi utilizada em ambos os métodos. RESULTADOS: Efeito analgésico relacionado à dose foi observado no teste da formalina. Tramadol nas doses mg injetado intraplantar, bloqueou completamente a hiperalgesia no teste da formalina durante a primeira fase, enquanto 1,25 mg aboliu a primeira e diminuiu, mas não bloqueou, a segunda fase do teste. Esta mesma dose de tramadol por via perineural em bloqueio de nervo ciático foi tão efetiva quanto a injeção intraplantar. Tramadol 5 mg por via sistêmica reduziu apenas a segunda fase do teste da formalina. No modelo de incisão plantar, tramadol 5 mg injetado intraplantar, bloqueou completamente a hiperalgesia mecânica induzida por monofilamentos de Von Frey, enquanto a mesma dose de tramadol via sistêmica, foi eficaz somente após 45 minutos da injeção. O efeito analgésico do tramadol intraplantar foi antagonizado por naloxona administrada por via sistêmica, 45 minutos após a injeção, enquanto a injeção intraplantar de naloxona não inibiu o efeito do tramadol. CONCLUSÕES: O tramadol induz analgesia de um modo dependente da dose. Tramadol intraplantar tem efeito analgésico rápido, prolongado e não mediado por receptores opióides nos dois modelos estudados. Além disso possui ação analgésica intensa e precoce quando administrado por via perineural de modo semelhante aos anestésicos locais.INTRODUCTION: Tramadol is a centrally and peripherally-acting drug, found as a racemic mixture of two enantiomers (+) and (-)-tramadol and effective in the treatment of moderate to severe pain. Tramadol has an -opioid effect ten times less potent than codeine. After first pass metabolism, tramadol is metabolized to various compounds and its major metabolites, (+) and (-)-odesmethyl- tramadol (M1), are therapeutically active as an analgesic and has opioid affinity similar to codeine. Tramadol reduces the peak amplitude of compound action potentials of isolated sciatic nerves and is utilized as adjuvant to lidocaine in brachial plexus blockade in humans. METHODS: Male Wistar rats, 5 to 6 per group were enrolled in the experiments. Two animal models of hyperalgesia were studied: nociceptive flinching behavior induced by formalin and mechanical hyperalgesia after plantar incision. Systemic and intraplantar tramadol were utilized in the two models. Perineural tramadol was injected by the sciatic nerve after localization with nerve stimulator. Opioid receptor antagonist, naloxone, was used in both methods. RESULTS: Dose dependent effect was observed in the flinching behavior test. Five and 2.5 mg intraplantar tramadol completely blocked the first phase formalin test while 1.25 mg abolished the first phase and diminished, but not blocked the second phase. Systemic 5 mg tramadol reduced the second phase of the flinching behavior test without interfering with the first phase. Perineural tramadol was equally effective as intraplantar tramadol at the same dose. In the plantar incision model, 5 mg intraplantar tramadol completely blocked mechanical hyperalgesia with Von Frey monofilaments test; systemic tramadol in the same dose was effective only after 45 minutes of injection. Systemic naloxone antagonized the analgesic effect after 45 minutes of intraplantar tramadol, while intraplantar naloxone was not effective. CONCLUSIONS: Tramadol reduces analgesia in a dose dependent way. Intraplantar tramadol has an early and prolonged analgesic effect not mediated by opioid receptors in the two studied models. Besides, it has an early and important analgesic effect when perineurally administered with a weak motor effect similar to local anesthetics
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MacDonald, Ellen. "Effect of Nitrous Oxide and a Combination of Lidocaine/Clonidine on the Success of the Inferior Alveolar Nerve Block in Patients with Symptomatic Irreversible Pulpitis." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1564678915719937.
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Kushnir, Ben. "Nitrous oxide/oxygen effect on dental injection pain and mandibular pulpal anesthesia." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1564680038231171.
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Stentz, Daniel S. "EFFECT OF NITROUS OXIDE/INTRANASAL KETOROLAC COMBINATION ON THE SUCCESS OF THE INFERIOR ALVEOLAR NERVE BLOCK IN PATIENTS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1470664281.
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Axelsson, Emil, and Albin Altersved. "Anesthetic efficacy of lidocaine and prilocaine for inferior alveolar nerve block in endodontic treatment of adult patients with symptomatic pulpitis - A pilot study." Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19628.
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Syftet med denna randomiserade kliniska studie var att jämföra anestesieffekten mellan 2 % lidocain med 1:200,000 adrenalin och 3 % prilocain med 0,03 i.u./ml felypressin vid en blockad av Nervus alveolaris inferior för behandling av patienter med symtomatisk pulpit i en underkäksmolar eller –premolar.Materialet utgjordes av 5 patienter som uppsökt Tandvårdshögskolans jourmottagning för akuta besvär. Patienterna fick upp till 3,6 ml av antingen 2% lidocain (n=4) eller 3% prilocain (n=1). Det valda medlet var okänt för både patient och behandlare under hela behandlingen. Behandling (pulpotomi) påbörjades först när patienten erhållit bedövad läpp. Information om smärta före och under behandling, intag av analgetika och oro inför behandling noterades. Lyckad anestesi ansågs vara ingen eller endast mild smärta under behandling (<54 mm av 170 mm på en visuell analog skala).Lyckandefrekvensen för lidocain var 50 % och för prilocain 100 %. Det insamlade materialet var för litet för möjliggöra statistisk analys.De patienter som inkluderades i denna pilotstudie var för få för att visa eventuella skillnader i anestesieffekt mellan lidocain och prilocain vid en blockad av Nervus alveolaris inferior för behandling av patienter med symtomatisk pulpit i en underkäksmolar eller –premolar. Ett större underlag krävs för att kunna dra slutsatser om något av de testade bedövningsmedlen är överlägset. Ett stickprov på 57 deltagare i varje grupp krävs för att upptäcka en skillnad i lyckandefrekvens på 25 % (power 80 %). Protokollet har nu testats och visat sig vara lämpligt att använda i en större studie.The aim of this randomized clinical trial was to compare the anesthetic efficacy of 2% lidocaine with 1:200,000 epinephrine and 3% prilocaine with 0,03 i.u./ml felypressin used for the inferior alveolar nerve block (IANB) in endodontic treatment of adult patients with symptomatic pulpitis in posterior mandibular teeth.5 patients visiting the emergency clinic of the Faculty of Odontology, Malmö University participated in the study. They randomly received, in a double-blind manner, up to 3,6 ml of either 2% lidocaine (n=4) or 3% prilocaine (n=1) in a conventional IANB. Treatment (pulpotomy) was only initiated after profound lip numbness was obtained. Pre- and perioperative pain, intake of analgesics and anxiety was recorded. Anesthetic success was defined as no or only mild pain (a rating of <54mm on a 170mm Visual Analogue Scale) during treatment.The success rate for IANB using lidocaine was 50% and for prilocaine 100%. The material size was insufficient to enable statistical analysis.The few patients selected for this pilot study were insufficient to assess any difference in anesthetic efficacy between lidocaine and prilocaine for IANB in endodontic treatment of adult patients with symptomatic pulpitis in a posterior mandibular tooth. Further data collection is needed to make conclusions about possible superiority of any of the tested substances. A sample size of 57 test subjects in each group would give a power of 80% to detect a difference of 25% in success rate. The protocol appears to be suitable for use in a larger-scale study.
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Remerand, Francis. "Innervation sensitive de la paume de la main : étude fonctionnelle, topographique et morphologique : application à l'anesthésie locorégionale." Thesis, Tours, 2011. http://www.theses.fr/2011TOUR3313/document.
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En pratique clinique, les résultats de l’Anesthésie Loco-Régionale diffèrent parfois notablement de ceux prévus par les traités d’anatomie. Le but de notre travail a été de montrer que les nerfs musculocutané (MC) et cutanémédial de l’avant-bras (CMAB) participent fréquemment à l’innervation cutanée de la paume de la main. L’analyse multivariée de 551 patients opérés du canal carpien a révélé que l’absence de bloc du nerf MC était associée aux échecs de l’ALR. Pourtant, ce résultat était en partie masqué par une fréquente diffusion d’anesthésique local du nerf médian vers le nerf MC au bras, comme le prouve l’étude échographique de l’anatomie des nerfs au creux axillaire chez 387 autres patients. Une cartographie du territoire cutané des nerfs MC (N=28) et CMAB (N=2l) à la face antérieure de la main et du poignet a révélé des territoires bien plus étendus que ceux décrits dans la littérature. Les microdissections de ces 2 nerfs sur 23 membres supérieurs ont permis d’associer les différents types de territoires décrits lors des cartographies à diverses configurations anatomiques. Il convient donc d’anesthésier ces deux nerfs pour toute chirurgie de la paume de la mainIn daily practice, the extent of peripheral nerve blockade often differs from the one predicted by referencetextbooks. In this work, we strived to demonstrate that musculocutaneous (MC) and medial antebrachialcutaneous (MABC) nerves participate frequently in the palm innervation. A multivariate analysis of 551 patients operated from carpal tunnel release showed that the absence of MC nerve block was associated with anesthesia failure. Yet, these results were minimized by frequent local anesthetic diffusion from the median nerve to the MC one at the arm, as demonstrated by our anatomical study of the nerves in 387 ultrasound guided axillary blocks. Cutaneous territory mapping of MC (N28) and MABC (N=2 1) nerves revealed their territories were far more extended than the ones described in reference textbooks. Microdissections of these nerves on 23 upper limbs allow to associate the different types of territories with several anatomical patterns. Therefore, MC and MABC nerve should be blocked when considering any palm surgery
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Haro, Álvarez Ana Paulina. "Uso de la ecografía para el bloqueo de los nervios periféricos del miembro pelviano en el gato (Felis catus L.)." Doctoral thesis, Universidad de Murcia, 2013. http://hdl.handle.net/10803/117354.
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Tesis por compendio de publicacionesEl presente estudio fue llevado a cabo para describir la apariencia ecográfica y desarrollar los abordajes ecoguiados para el bloqueo de los nervios ciático y femoral, así como evaluar la eficacia clínica del bloqueo ecoguiado del nervio ciático en el gato. Se realizaron disecciones anatómicas y criosecciones para determinar las marcas anatómicas para localizar los nervios de interés. La apariencia ecográfica de los nervios ciático y femoral fue estudiada tanto en cadáveres como en gatos vivos, utilizando un transductor linear de 4-13 MHz. EL bloqueo ecoguiado del nervio ciático se realizó insertando una aguja para bloqueo de nervios periféricos cerca del nervio ciático y se infiltró lidocaína alrededor del mismo. El abordaje medio-femoral y el abordaje dorsal permitieron la evaluación ecográfica y aproximación ecoguiada de los nervios ciático y femoral respectivamente. El abordaje medio-femoral permitió el bloqueo clínicamente efectivo del nervio ciático en el gato. Palabras clave: ecografía, anestesia, anestesia regional, bloqueo de nervios periféricos, nervio ciático, nervio femoral, gato.
Use of ultrasound for the blockade of the peripheral nerves of the pelvic limb in the cat (Felis catus L.) This study was carried out to describe the ultrasonographic appearance and to develop the ultrasound (US)-guided approaches to block the sciatic (SCN) and femoral (FN) nerves, and to evaluate the clinical efficacy of the US-guided blockade of the ScN in the cat. Anatomical dissections and transversal cryosections were performed to determine the anatomical landmarks to localise the ScN and FN nerves. The ultrasonographic appearance of the ScN and FN were determined on cadavers and alive cats using a 4-13MHz linear transducer. The US-guided blockade of the ScN was performed inserting a peripheral nerve block needle close to the ScN and lidocaine was infiltrated around it. The midfemoral approach for the ScN and the dorsal approach for the FN, allowed an optimal US-guided location to evaluate and block these nerves. The midfemoral allowed an accurate US-guided blockade of the ScN in felines.
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Visconti, Renata Pieroni. "Eficácia anestésica da mepivacaína e da lidocaína no bloqueio mandibular em molares inferiores com pulpite irreversível." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-09112010-115728/.
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Neste estudo, randomizado, duplo cego, avaliamos a eficácia anestésica em quarenta e dois pacientes, do Setor de Urgência da Faculdade de Odontologia da Universidade de São Paulo, com pulpite irreversível, que receberam mepivacaína 2% (n=21) ou lidocaína 2% (n=21) associadas à epinefrina 1:100.000 para bloqueio do nervo alveolar inferior (BNAI). O sinal subjetivo de anestesia do lábio e língua, a presença de anestesia pulpar e ausência de dor durante o procedimento de pulpectomia foram avaliados, respectivamente, por indagação ao paciente, pelo testador elétrico pulpar (TEP) e pela escala de dor verbal (VAS). Pela técnica pterigomandibular indireta das três posições, foi injetado primeiramente um tubete (1,8mL), e depois de 10 minutos, foi testada a anestesia pulpar (AP), pelo TEP, por duas leituras negativas ao estímulo máximo (80A) do aparelho. Quando não instalada a AP, um segundo tubete (mais 1,8mL) era reinjetado. Confirmada a anestesia pulpar, iniciava-se a pulpectomia. O sucesso do BNAI foi definido como a capacidade de acessar a câmara pulpar e a realização da pulpectomia sem relato de dor (VAS) pelo paciente (escore 0 ou 1), enquanto o insucesso foi caracterizado pelo incomodo/dor (escore 2 ou 3), que impedisse a continuação. Nesse caso, um terceiro e último tubete foi dado por técnicas complementares (intraligamentar ou intrapulpar) para finalizar o procedimento. Na análise estatística utilizou-se o teste Exato de Fisher e ANOVA com nível de significância fixado em 5%. Obtivemos que no grupo Mepivacaína com 1,8mL, a taxa de anestesia pulpar (AP) foi de 52% (11/21), e sucesso no BNAI de 55% (6/11); a injeção de mais 1,8mL (2º tubete) aumentou a AP para 86% (18/21) e o sucesso no BNAI para 55% (10*/18). No Grupo Lidocaína, com 1.8mL, a taxa da AP foi de 33% (7/21), o BNAI foi de 0%; com mais 1,8mL (2º tubete), a AP aumentou para 67% (14/21) e sucesso no BNAI para 14% (2*/14) (*com diferença estatística onde p0,05). A mepivacaína com volume menor proporcionou, clinicamente, maior índice de anestesia pulpar e sucesso do BNAI (pulpectomia total), e permitiu chegar mais próximo da polpa quando comparada a lidocaína. Concluímos que a mepivacaína obteve melhores resultados no sucesso do BNAI para a realização da pulpectomia em molares inferiores com pulpite irreversível.The aim of this, double blind randomized study, was to evaluate the anesthetic efficacy of inferior alveolar nerve block (IANB) using 2% mepivacaine and 2% lidocaine both associated with adrenaline 1:100,000 in molars with irreversible pulpitis. The sample of these study consisted of forty-two healthy patients diagnosed with irreversible pulpitis actively experiencing pain. For blocking the IAN was established the following protocol: injection of one cartridge (1.8 mL) by the technique pterigomandibular of three indirect positions, expected 10 minutes and electric pulp test (EPT) Vitality Scanner®-SybronEndo, USA was accomplishment. If tooth sensitivity pain persisted another cartridge (plus 1.8 mL) was given by the same technique and the same methodology was performed. The pulpectomy was continued after the confirmation of pulpal anesthesia, which was established as the lack of response at maximum stimulation (80A) of EPT. In cases where the patient reported pain during pulpectomy even confirmed the blockage, a third cartridge was given by complementary techniques (intraligamentary or intrapulpal) to complete the endodontic procedure. The anesthetic efficacy in IANB was established when the pulpectomy was performed without report of pain and without complementation. For analysis and comparison of results we used the Fisher exact statistical test and ANOVA with significance level set at 5%. Regarding the effectiveness of the anesthetic with 1,8 mL mepivacaine, determined pulpar anesthesia (PA) was 52% (11/21), and success in IANB (pulpectomy) 55% (6/11), the most injection of 1,8 mL, increased 86% (18/21) for AP and success in IANB to 55% (10*/18). In the lidocaine group, with 1.8mL, AP rate was 33% (7/21), the IANB was 0%, with a further 1.8 mL (cartridge 2) the AP increased to 67% (14/21) and success was to IANB 14 % (2*/14), (*statistically difference p 0.05). Mepivacaine with smaller volume clinically provided a higher rate of pulpal anesthesia and most successful of IANB (pulpectomy total), allowing to reach nearest dental pulp than lidocaine. Concluded that mepivacaine performed better in success of IANB (pulpectomy) that lidocaine in molars with irreversible pulpitis
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Carnaval, Talita Girio. "Influência da codeína, associada ou não ao anestésico local, na duração do bloqueio sensitivo, motor e proprioceptivo do nervo ciático de rato." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-20032015-173942/.
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A melhora na eficácia do bloqueio sensitivo induzida pela associação ou injeção prévia do opióide tramadol foi comprovada em animais e em humanos, sugerindo potencialização ou sinergismo de efeitos. No entanto, ainda não há estudos sobre a influência da associação da codeína ao anestésico local (AL) injetada concomitante ou previamente ao bloqueio funcional (sensitivo, motor e proprioceptivo) do nervo ciático. Dessa forma, o objetivo deste trabalho foi estudar a influência do analgésico opióide codeína na duração do bloqueio nervoso ciático de rato induzido por lidocaína, através de novos protocolos farmacológicos. Para isso, foi realizada uma análise da função sensitiva, proprioceptiva e motora desse nervo misto, comparando-se os efeitos da injeção prévia ou concomitante da codeína. Foram utilizados 80 ratos machos Wistar para serem avaliados funcionalmente após o recebimento na região do nervo ciático de soluções injetáveis dos diferentes fármacos: lidocaína com epinefrina (AL), AL sem vasoconstritor (AL SV), codeína (COD), tramadol (TRAM), AL + codeína (AL + COD), AL + tramadol (AL + TRAM), codeína 20 min antes do AL (COD 20 + AL) ou tramadol 20 min antes do AL (TRAM 20 + AL). O bloqueio sensitivo foi considerado o período de ausência do reflexo de retirada da pata após estímulo nociceptivo-pressórico (analgesímetro e pinça mosquito), já o bloqueio motor pela duração da claudicação (ausência do reflexo extensor postural) e o proprioceptivo, pela ausência de resposta do salto e tato (escore 0-3). A duração de ação do (AL + COD) foi maior (p<0.01) que a (COD) e que (COD20´+ AL) e os outros grupos (p<0.05). O COD isolado mostrou discreta atividade nociceptiva. Os resultados sugerem sinergismo de atividade entre opióide e AL. O uso concomitante de codeína ao AL melhora a eficácia do bloqueio sensitivo, motor e proprioceptivo, abrindo nova perspectiva no controle da dor a ser estudada em Odontologia.The improvement in sensitive blockade induced by association or previous tramadol opioid injection was proved in animals and humans suggesting potencialization or sinergism in effects. Nevertheless, there are no experiments about the influence of codeine association to local anesthetics (LA) injected simultaneously or previously to block sciatic nerve functions (sensitive, motor and proprioceptive). The propose of this experiment was evaluate the influence of codeine analgesic opioid on duration of rat sciat nerve blockade induced by lidocaine using new pharmacological protocols. It was anallyzed the nociceptive, motor and proprioceptive functions of this mist nerve comparing the effects of previous or associated injection of codeine. Eighty (N=80) Wistar male rats were functional avaliated after they received differents injected drugs solutions, in sciat nerve region: lidocaine and epinephrine (LA), local anesthetics with no vasoconstrictor (LA NV), codeine (COD), tramadol (TRAM), LA + codeine (LA + COD), LA + tramadol (LA + tramadol), codeine 20 minutes previously to LA (COD 20+ LA) or tramadol 20 minutes previously to LA (TRAM 20 + LA). The sensitive blockade was considered the absence of withdraw reflex after nociceptive and pressoric stimulous (analgesimether and forceps), the motor was evaluated the duration of claudication and proprioceptive by de absence of hopping and tactile response (score 0-3). We concluded that the blockade duration of (LA + COD) was greater than (COD) (p<0.01) and than (COD 20 + LA) and than other groups (p<0.05). Codeine isolated showed discret nociceptive action. Our results suggested sinergism between opioid and LA. The associated use of codeine and LA improves de efficacy of sensitive, motor and proprioceptive blockade guiding to a new prospect in dentistrys pain control.
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Balthazar, Daniel de Almeida. "Desenvolvimento de t?cnica para bloqueio dos nervos medianoulnar e radial em patos (Cairina moschata)." Universidade Federal Rural do Rio de Janeiro, 2016. https://tede.ufrrj.br/jspui/handle/jspui/1457.
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The success of peripheral nerve blocking techniques requires precise knowledge of the anatomical area to be blocked, thus yielding accurate local anesthetic administration and a reduction on the anesthetic dosage. The aim of this study was to develop a regional anesthesia method for locomotor appendage. We performed anesthetic block of median ulnar and radial nerves in muscovy duck (Cairina moschata) with 2% lidocaine guided by peripheral nerve stimulator, followed by evaluation of effectiveness in ex vivo and in vivo studies. For anatomical study we used six cadaver ducks and in two of these was also performed the radiographic examination of the spine. Based on the anatomical study we defined and described two access points to block the forelimb. In a muscovy duck body methylene blue was injected with subsequent dissection and observation of the nerve and the surrounding regions? colors. In vivo studies were performed in domestic duck specimens, consisting of an initial pilot study with two animals to determine the electric system for neurolocalization and later evaluation of the motor and nociceptive response to blockage of medianoulnar and radial nerve in six duck specimens, female, adult, middle weight 1,42kg. After induction with isoflurane, animals underwent neurolocalization technique by starting the nerve stimulation with a current of 0.7 mA, frequency of 2 Hz and pulse duration of 300 ?Seg. We gradually decreased the current to 0.2 mA to induce a motor response, and 0.18 mA to induce no response. Each animal had one wing injected with lidocaine 2% (6 mg/kg), being the Treated Group, and a wing injected with the same volume of saline 0.9%, being the Control Group, in blind technique. Isoflurane was then interrupted. The evaluation of sensory and motor response was expressed as scores and started 3 minutes after extubation, followed by observation at 5, 10, 15 and 20 minutes, and then every 10 minutes untill the end of the block. Radiographic examination of the spine and the anatomical study revealed that the duck has four roots that unite into a single trunk and then originate the major nerves: axillary, radial, medianoulnar and breastplate. During the methylene blue dispersion study, nerves were presented pigmented to a large extent, demonstrating that the application points and the volume of anesthetic applied were satisfactory. The in vivo study showed a statistically significant difference in scores of muscle relaxation between the treated and control groups in times 5-40 minutes and sensory block in times 3-50 minutes. The duration of sensory block ranged between 37-77 minutes (mean 51.67 + 17.28 minutes). We concluded that the medianoulnar and radial nerve block technique guided by peripheral nerve stimulator was effective when using 6 mg/kg of lidocaine, with successful blockade distal to the humerus-radio-ulnar joint.
O sucesso das t?cnicas de bloqueio de nervos perif?ricos requer conhecimento anat?mico preciso da ?rea a ser bloqueada, obtendo-se assim precis?o na administra??o do anest?sico local e diminui??o na dose de anest?sicos. O objetivo do presente estudo foi desenvolver um m?todo de anestesia regional do ap?ndice locomotor, por meio de bloqueio anest?sico dos nervos medianoulnar e radial em pato (Cairina moschata) com lidoca?na 2% guiado pelo estimulador de nervo perif?rico, com base em estudo anat?mico, avaliando-se sua efetividade em estudos ex vivo e in vivo. Para confec??o do estudo anat?mico foram utilizados seis cad?veres de patos e em dois destes cad?veres foi realizado tamb?m o exame radiogr?fico da coluna vertebral. Com base no estudo anat?mico foram definidos e descritos dois pontos de acesso para bloqueio do membro tor?cico, nos quais, em um cad?ver de pato, foi injetado azul de metileno com posterior dissec??o e observa??o da colora??o dos nervos e das regi?es circundantes. Os estudos in vivo foram realizados em esp?cimes de pato dom?stico, constando inicialmente de estudo piloto com dois animais para determina??o do regime el?trico para a neurolocaliza??o e posteriormente de avalia??o da resposta motora e nociceptiva ao bloqueio dos nervos medianoulnar e radial, em seis exemplares de pato, f?meas, adultas, peso m?dio de 1,42kg. Ap?s indu??o com isoflurano os animais foram submetidos ? t?cnica de neurolocaliza??o, iniciando-se a estimula??o do nervo com corrente de 0,7 mA, frequ?ncia de 2Hz e dura??o do pulso de 300 ?Seg, diminuindo-se gradativamente at? obten??o da resposta motora com 0,2 mA e aus?ncia de resposta com correntes de 0,18 mA. Em cada animal uma das asas recebeu inje??o de lidoca?na 2%, na dose de 6 mg/kg (Grupo Tratado) e a asa oposta solu??o salina 0,9% (Grupo Controle), em igual volume, em t?cnica cega, interrompendo-se ent?o o fornecimento de isoflurano. A avalia??o das respostas sensitiva e motora foi expressa em escores e teve in?cio tr?s minutos ap?s a extuba??o, seguida de observa??o aos cinco, 10, 15 e 20 minutos, prosseguindo no grupo Tratado a cada 10 minutos, at? a observa??o do fim do bloqueio. O exame radiogr?fico da coluna vertebral e o estudo anat?mico revelaram que o pato possui quatro ra?zes nervosas que se unem em um tronco ?nico e desse originam-se os principais nervos: axilar, radial, medianoulnar e peitoral. Durante o estudo de dispers?o de azul de metileno os nervos apresentaram-se pigmentados em uma grande extens?o, demonstrando que os pontos de aplica??o determinados e o volume de solu??o aplicada mostraram-se satisfat?rios. No estudo in vivo observou-se diferen?a estatisticamente significante nos escores de relaxamento muscular entre os grupos Tratado e Controle dos tempos 5 a 40 minutos, e de bloqueio sensitivo dos tempos 3 a 50 minutos. A dura??o do bloqueio sensitivo variou 37 a 77 minutos (m?dia 51,67 + 17,28 minutos). Conclui-se que a t?cnica de bloqueio dos nervos medianoulnar e radial guiada pelo estimulador de nervos perif?ricos foi efetiva quando se utilizou dose de 6 mg/kg de lidoca?na, promovendo o bloqueio da regi?o distal ? articula??o ?mero-radio-ulnar.
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Yoshimura, Hiroshi. "Attenuation of Mg^<2+>-block of synaptic N-methyl-D-aspartate receptors in the visual cortex of rats raised under optic nerve blockade." Kyoto University, 1997. http://hdl.handle.net/2433/202157.
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Allegretti, Carlos Eduardo. "Eficácia da articaína, da lidocaína e da mepivacaína associadas à epinefrina em pacientes com pulpite irreversível em molares mandibulares." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-16012013-113534/.
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O objetivo deste estudo foi comparar a eficácia anestésica da articaína 4%, da lidocaína 2% e da mepivacaína 2%, todas associadas à epinefrina 1:100.000, durante pulpectomia em pacientes com pulpite irreversível em molares mandibulares. Sessenta e seis voluntários do Setor de Urgência da Faculdade de Odontologia da Universidade de São Paulo receberam, aleatoriamente, 3,6ml de um dos anestésicos locais para o bloqueio convencional do nervo alveolar inferior (NAI). No caso de falha do bloqueio, foram administrados 3,6ml da mesma solução como injeção complementar no ligamento periodontal. O sinal subjetivo de anestesia do lábio, a presença de anestesia pulpar e ausência de dor durante a pulpectomia foram avaliados, respectivamente, por indagação ao paciente, por meio do aparelho estimulador pulpar elétrico (pulp tester) e por uma escala analógica verbal. A análise estatística foi realizada por meio dos testes Qui-quadrado, Kruskal Wallis e Razão de Verossimilhancas. Todos os pacientes reportaram anestesia no lábio após o bloqueio do NAI. A mepivacaína apresentou valores superiores (68,2%) para a anestesia pulpar após o bloqueio do NAI e a lidocaína (90%) após a injeção no ligamento periodontal. A mepivacaína apresentou valores superiores para a analgesia (72,7%) após o bloqueio no NAI e a lidocaína (90%) após a injeção no ligamento periodontal. Após a falha do bloqueio do NAI, a dor na câmara pulpar foi a mais frequente e após a falha da injeção no ligamento periodontal, a dor no canal. No entanto, essas diferenças não foram estatisticamente significantes. Portanto as três soluções anestésicas locais se comportam de forma semelhante e não apresentam efetivo controle da dor no tratamento da pulpite irreversível em molares mandibulares.The aim of this study was to compare the anesthetic efficacy of 4% articaine, lidocaine 2% and 2% mepivacaine, all associated with epinephrine 1:100,000 during pulpectomy in patients with irreversible pulpitis in mandibular molars. Sixty-six volunteers Sector Emergency Faculty of Dentistry, Universidade de São Paulo randomly received 3.6 ml of a local anesthetic to block conventional inferior alveolar nerve. In case of failure of the lock, were administered 3.6 ml of the same solution as in the periodontal ligament injection complement. The signal subjective lip anesthesia, the presence of pulpal anesthesia and no pain during pulpectomy were evaluated respectively by questioning the patient, via the stimulating device electrical pulp (pulp tester) and a verbal analogue scale. Statistical analysis was performed using the chi-square test, Kruskal Wallis and likelihood ratio. All patients reported lip anesthesia after blockade of the inferior alveolar nerve. The mepivacaine showed higher values (68.2%) for pulpal anesthesia after blockade of the inferior alveolar nerve and lidocaine (90%) after injection in the periodontal ligament. The mepivacaine showed higher values for analgesia (72.7%) after blocking the inferior alveolar nerve and lidocaine (90%) after injection in the periodontal ligament. After the failure of the blockade of the inferior alveolar nerve, the pain in the pulp chamber was the most frequent and after the failure of the periodontal ligament injection, pain in the channel. However, these differences were not statistically significant. Therefore, the three local anesthetic solutions behave similarly and did not exhibit effective pain management in treating irreversible pulpitis in mandibular molars.
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Sampaio, Roberta Moura. "Eficácia da articaína, da bupivacaína e da lidocaína associadas à epinefrina em pacientes com pulpite irreversível em molares mandibulares." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-17062015-131829/.
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O objetivo deste estudo foi comparar a eficácia anestésica da articaína 4%, da lidocaína 2%, ambas associadas à epinefrina 1:100.000, e da bupivacaína 0.5%, associada à epinefrina 1:200.000, durante pulpectomia em pacientes com pulpite irreversível em molares inferiores. Cento e cinco voluntários do Setor de Urgência da Faculdade de Odontologia da Universidade de São Paulo receberam, aleatoriamente, 3,6mL de um dos anestésicos locais para o convencional bloqueio do nervo alveolar inferior (BNAI). No caso de falha do BNAI, foram administrados 3,6mL da mesma solução como injeção complementar no ligamento periodontal. O sinal subjetivo de anestesia do lábio, a presença de anestesia pulpar e ausência de dor durante a pulpectomia foram avaliados, respectivamente, por indagação ao paciente, por meio do aparelho estimulador pulpar elétrico (pulp tester) e por uma escala analógica verbal. A análise estatística foi realizada por meio dos testes Qui-quadrado, Kruskal Wallis e Razão de Verossimilhanças. Foi adotado nível de significância de 0,05 (P <= 0,05). Todos os pacientes reportaram anestesia no lábio após o BNAI. A lidocaína apresentou valores superiores (42,9%) para a anestesia pulpar após o BNAI e após a injeção no ligamento periodontal (61,5%). A bupivacaína apresentou valores superiores para a analgesia (80%) após o BNAI e a lidocaína (92,3%) após a injeção no ligamento periodontal. Após a falha do BNAI, a dor na câmara pulpar foi a mais frequente para articaína e lidocaína e na dentina para a bupivacaína e após a falha da injeção no ligamento periodontal, a dor foi similar para articaína nas diferentes regiões; câmara, canal e dentina; para a bupivacaína foi mais frequente na dentina e para a lidocaína no canal. No entanto, essas diferenças não foram estatisticamente significantes. Portanto as três soluções anestésicas locais se comportam de forma semelhante e não apresentam efetivo controle da dor no tratamento da pulpite irreversível em molares inferiores.The aim of this study was to compare the anesthetic efficacy of 4% articaine and 2% lidocaine both associated with 1:100,000 epinephrine and 0.5% bupivacaine associated with 1:200,000 epinephrine in patients with irreversible pulpitis of the mandibular molars during a pulpectomy procedure. One hundred and five volunteers from the Emergency Center of the School of Dentistry at University of São Paulo randomly received 3.6 mL of local anesthetic as a conventional inferior alveolar nerve block (IANB). The subjective signal of lip numbness, pulpal anesthesia and the absence of pain during the pulpectomy procedure were, respectively, evaluated by questioning the patient, stimulation using an electric pulp tester and a verbal analogue scale. Statistical analysis was performed using the chi-square test, Kruskal Wallis and likelihood rations. The level for significance of differences was P <= .05. All patients reported the subjective signal of lip numbness after the application of either IANB. Lidocaine showed higher values for pulpal anesthesia after the IANB (42.9%) and after injection in the periodontal ligament (61.5%). Bupivacaine presented higher values for analgesia after the IANB (80,0%) and lidocaine after injection in the periodontal ligament (92,3%). After the failure of the IANB, the pain in the pulp chamber was the most frequent to articaine and lidocaine and bupivacaine for dentin and after the failure of the periodontal ligament injection, the pain was equal to articaine in different regions, chamber, canal and dentin; for bupivacaine was greater in dentin and lidocaine was higher in the channel. However, these differences were not statistically significant. So the three local anesthetic solutions behave similarly and not present any effective pain control in the treatment of irreversible pulpitis in mandibular molars.
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Alzahrani, Fatma Salem. "Comparative studies of the anaesthetic efficacy of 4% articaine used as mandibular infiltration versus 2% lidocaine used as inferior dental nerve block in extraction and pulpotomy of mandibular primary molars." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/11237/.
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Global abstract: The research presented in this thesis is in several parts. Firstly, the aim of systematic review was to systematically review available evidence on the efficacy of two local anaesthetic solutions lidocaine and articaine used for dental treatment in children. The findings from this review served as a basis for the next phase of the project, which was to address the deficiencies identified from the systematic review. This took the form of a Randomised Controlled Trial, the aim of which was to carry out an equivalence parallel prospective, randomised, controlled study, in order to evaluate and compare the anaesthetic efficacy of mandibular infiltration using 4% articaine (1:100,000 epinephrine) with mandibular nerve block using 2% lidocaine (1:80,000 epinephrine) in the extraction and restoration of mandibular primary molars. The translational intention was to be able to recommend the most effective and acceptable method of achieving anaesthesia for dental treatment of mandibular primary molars in children. In addition, a mixed method research strategy was implemented, in order to assess and explore the child’s experience associated with dental injection, and compare the two different techniques that were used (buccal infiltration and inferior dental nerve block). This comparison was in terms of children acceptance as well as parent satisfaction of their child’s dental treatment under local anaesthesia and their perception of the impact of this treatment on their child. Methods: Systematic review: A systematic search was conducted on Cochrane CENTRAL Register of Controlled Trials, MEDLINE (OVID; 1950 to June 2013), Cumulative Index to Nursing and Allied Health Literature (CINAHL; EBSCOhost; 1982 to June 2013), EMBASE (OVID; 1980 to June 2013), SCI-EXPANDED (ISI Web of Knowledge; 1900 to June 2013), key journals, and previous review bibliographies through June 2013. No restrictions were placed on years, language or publication status. Original research studies that compared articaine with lidocaine in children dental treatment were included and methodological quality assessment including assessment of risk of bias was carried out for each of the included studies. RCT: In total 98 children aged 5–9 years old were randomly assigned into two groups: one group (treatment group) received mandibular infiltration with 4% articaine with 1:100,000 epinephrine; the other group (control group) received an inferior alveolar nerve block with 2% lidocaine with 1:80,000 epinephrine. All local anaesthetic injections were given by a single operator, who had the role of assessing the presence/absence of pain as well as the child’s behaviour during the injection and treatment procedures (using W-BFRS, VAS and Frankl Behaviour Scale). Each child received one treatment for one tooth only. Qualitative sub-study: Concurrent mixed method data collection strategies were used. The qualitative and quantitative data were collected from the same participants as well as in the same timeframe. Thematic analysis was performed on the semi- structured interviews. Results: Systematic review: Electronic searching identified 520 publications. After the primary and secondary assessment process, only three studies were included in the final analysis. The RCTs included in this review investigated the efficacy of local anaesthetic solutions when given as a combination of both techniques, local infiltration as well as block anaesthesia. The data analyses showed superiority of articaine over that of lidocaine in terms of achieving anaesthetic success, although these results were not statistically significant. RCT: During the injection phase the absolute differences between the two anaesthetic techniques using W-BFRS VAS and behaviour scales was zero (no difference), 0.060 (95% CI -0.110 to 0.230) and -0.080 (95% CI -0.190 to 0.030) respectively. During the treatment phase, the absolute difference were -0.020 (95% CI -0.180 to 0.140), -0.040 (95% CI -0.220 to 0.150) and zero (no difference). The equivalence margin was set at ± 0.2 and all comparisons showed equivalence of the two treatments except for the comparison of VAS during injection and W-BFRS during treatment with the 95% confidence intervals exceeding the equivalence margin. Qualitative sub-study: A total of 42 (56%) participants in the qualitative part of the study, were in articaine group while 31 (41%) were in lidocaine group. Only two of the participants (3%) had received both local anaesthetics. Parent’s responses to the questionnaire reflected their opinion based on their observation of the dental treatment. Majority of the parents were happy about the treatment in general. The children’s responses were very positive as well. The questionnaire/interviews with the children, parents, along with the dentist’s comments, allowed the development of three major themes addressing the aims and purposes of the study. The three major themes emerged were: Firstly, “Experience of the anaesthetic procedures”. Second major theme “Ease vs difficulty of the dental treatment” and the third major theme was “Perception of the dentist approach during the treatment”. Conclusion: The quality of the included RCTs in the systematic review was generally inadequate. All the included studies had several limitations in reporting which indicated a need for a randomised clinical trial with standardised methodology to address these limitations. The findings of the systematic review indicated that, articaine and lidocaine presented similar efficacy when used as infiltration and blocks respectively for routine dental treatments. The effect of numbness of soft tissues was longer using articaine than lidocaine, and few adverse events were reported following the use of both solutions. The results from this review indicate that articaine injections can cause slightly more post injection pain in the area injected than lignocaine, the difference was not statistically significant. Overall, the results of the present RCT pointed out that it would be acceptable to carry out invasive dental treatment for mandibular molars with the administration of infiltration with buccal intrapapillary infiltration using 4% articaine instead of the traditional method of inferior dental block using lidocaine, which many children find difficult to cope with. Considering the findings from the survey, along with the results from the questionnaire/interview, it was established that, the reactions of the patients with both of the local anaesthetics were very similar. The interview findings added meaning and depth to the survey findings, in terms of explaining and clarifying the children’s responses and answers. Parents/children reported a high degree of satisfaction with the treatment outcomes. The satisfaction expressed by parents/children can have a positive impact on the children’s future dental treatment.
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Yavari, Samaneh [Verfasser]. "The comparison of four-point Nerve Block Anaesthesia and Intravenous Regional Anaesthesia of the distal hind limb in cattle: efficacy, onset and hormonal-metabolic and cardio-respiratory stress responses / Samaneh Yavari." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2016. http://d-nb.info/1126464791/34.
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Fernandes, Marcos Rassi. "Qualidade de vida e capacidade funcional de pacientes com capsulite adesiva submetidos a bloqueios do nervo supraescapular." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/4613.
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Introduction: The simultaneous assessment of quality of life and functional capacity from the patient's self perception with adhesive capsulitis may contribute to the improvement of health care of this population. Objectives: To describe the techniques and clinical indications of suprascapular nerve block, as well as their complications, based on literature data; to assess the quality of life and functional capacity of patients with adhesive capsulitis at the beginning and end of treatment with blocks and to analyze the factors associated with satisfactory quality of life and better functional capacity. Methods: Prospective clinical study in adults and elderly patients with adhesive capsulitis submitted to weekly treatment with suprascapular nerve blocks, users of a private orthopaedic hospital, located in the city of Goiânia-GO, in the period of august 2010 to february 2012. Quality of life was assessed by the WHOQOL-BREF and functional capacity by DASH at the beginning and end of treatment. The Constant score greater than or equal to 55 points was used for the end of the blocks and the Wilcoxon test to compare the initials and finals scores of the WHOQOL-BREF and DASH. Multiple regression analysis of Poisson was carried out using satisfactory quality of life and better functional capacity as outcomes. Significance level of 5%. Results: Forty-three patients with a mean age of 54,7 years were evaluated. Better scores of quality of life and functional capacity were obtained at the end of treatment, when compared to the initials scores. Patients with age greater than 50 years old were associated with higher scores of quality of life in the physical and psychological WHOQOL-BREF domains and those with better educational level in the physical and environmental domains. Age greater than 50 years old and higher schooling were also associated with better functional capacity of the affected shoulder. Conclusions: There are several techniques and clinical indications for the performance of the suprascapular nerve block. Although rare, complications may occur. Quality of life and shoulder functional capacity of patients with adhesive capsulitis improved at the end of the treatment with suprascapular nerve blocks, being influenced by the higher age and better educational level.
Introdução: A avaliação simultânea da qualidade de vida e da capacidade funcional, a partir da percepção dos próprios pacientes portadores de capsulite adesiva, pode contribuir para a melhoria da atenção à saúde dessa população. Objetivos: Descrever as técnicas e indicações clínicas do bloqueio do nervo supraescapular, bem como suas complicações, a partir de dados da literatura; avaliar a qualidade de vida e a capacidade funcional de pacientes com capsulite adesiva no início e no final do tratamento com bloqueios e analisar os fatores associados à qualidade de vida satisfatória e à melhor capacidade funcional. Métodos: Estudo clínico prospectivo em pacientes adultos e idosos com capsulite adesiva submetidos a tratamento semanal com bloqueios do nervo supraescapular, usuários de um hospital ortopédico privado, localizado na cidade de Goiânia-GO, no período de agosto de 2010 a fevereiro de 2012. A qualidade de vida foi avaliada pelo WHOQOL-BREF e a capacidade funcional pelo DASH, tanto no início quanto no final do tratamento. O escore de Constant maior ou igual a 55 pontos foi utilizado para o término dos bloqueios e o teste de Wilcoxon para comparar os escores iniciais e finais do WHOQOL-BREF e DASH. Foi realizada análise de regressão multivariada de Poisson, utilizando como desfechos a qualidade de vida satisfatória e a melhor capacidade funcional. Nível de significância de 5%. Resultados: Foram avaliados 43 pacientes, com idade média de 54,7 anos. Foram obtidos melhores escores de qualidade de vida e capacidade funcional no final do tratamento, quando comparados aos escores iniciais. Pacientes com idade maior que 50 anos foram associados a escores mais elevados de qualidade de vida nos domínios físico e psicológico do WHOQOL-BREF e aqueles com melhor nível educacional nos domínios físico e ambiental. Idade maior que 50 anos e maior escolaridade também foram associados à melhor capacidade funcional do ombro acometido. Conclusões: Existem diversas técnicas e indicações clínicas para a realização do bloqueio do nervo supraescapular. Apesar de raras, complicações podem ocorrer. A qualidade de vida e a capacidade funcional do ombro dos pacientes com capsulite adesiva melhoraram no final do tratamento com bloqueios do nervo supraescapular, sendo influenciadas pela maior idade e melhor nível educacional.