Dissertations / Theses: 'Neovascularization'

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Cleaver, Ondine Beatrice. "Neovascularization of the Xenopus embryo /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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Murohara, Toyoaki. "Angiogenesis and vasculogenesis for therapeutic neovascularization." Nagoya University School of Medicine, 2003. http://hdl.handle.net/2237/5392.

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Choi, Kim-ching Janie. "Vascular patterns and expression of angiogenesis-related molecules in non-small cell lung cancer." Click to view the E-thesis via HKUTO, 2003. http://sunzi.lib.hku.hk/hkuto/record/B31970953.

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Berglin, Lennart. "Choroidal neovascularization (CNV) : clinical and experimental aspects /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-284-1/.

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蔡劍菁 and Kim-ching Janie Choi. "Vascular patterns and expression of angiogenesis-related molecules in non-small cell lung cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B31970953.

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Steén, Björn. "Matrix metalloproteinases and their inhibitors in ocular neovascularization /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-712-6/.

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梁苑莊 and Yuen-chong Fiona Leung. "Neovascularization in the condyle during mandibular forward positioning." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31973097.

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Leung, Yuen-chong Fiona. "Neovascularization in the condyle during mandibular forward positioning." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B26144542.

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Eubank, Timothy D. "M-CSF and GM-CSF induce human monocytes to express either pro- or anti-angiogenic factors." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1069772001.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xx, 168 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Clay B. Marsh, Biochemistry Program. Includes bibliographical references (p. 150-168).

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Raines, Andrew Lawrence. "The role of biomaterial properties in peri-implant neovascularization." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41178.

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An understanding of the interactions between orthopaedic and dental implant surfaces with the surrounding host tissue is critical in the design of next generation implants to improve osseointegration and clinical success rates. Critical to the process of osseointegration is the rapid establishment of a patent neovasculature in the peri-implant space to allow for the delivery of oxygen, nutrients, and progenitor cells. The central aim of this thesis is to understand how biomaterials regulate cellular and host tissue response to elicit a pro-angiogenic microenvironment at the implant/tissue interface. To address this question, the studies performed in this thesis aim to 1) determine whether biomaterial surface properties can modulate the production and secretion of pro-angiogenic growth factors by cells, 2) determine the role of integrin and VEGF-A signaling in the angiogenic response of cells to implant surface features, and 3) to determine whether neovascularization in response to an implanted biomaterial can be modulated in vivo. The results demonstrate that biomaterial surface microtopography and surface energy can increase the production of pro-angiogenic growth factors by osteoblasts and that these growth factors stimulate the differentiation of endothelial cells in a paracrine manner and the results suggest that signaling through specific integrin receptors affects the production of angiogenic growth factors by osteoblast-like cells. Further, using a novel in vivo model, the results demonstrate that a combination of a rough surface microtopography and high surface energy can improve bone-to-implant contact and neovascularization. The results of these studies also suggest that VEGF-A produced by osteoblast-like cells has both an autocrine and paracrine effect. VEGF-A silenced cells exhibited reduced production of both pro-angiogenic and osteogenic growth factors in response to surface microtopgraphy and surface energy, and conditioned media from VEGF-A silenced osteoblast-like cell cultures failed to stimulate endothelial cell differentiation in an in vitro model. Finally, the results show that by combining angiogenic and osteogenic biomaterials, new bone formation and neovascularization can be enhanced. Taken together, this research helps to provide a better understanding of the role of material properties in cell and host tissue response and will aid in the improvement of the design of new implants.

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岑美恩 and Mei-yan Lily Shum. "Neovascularization in the glenoid fossa during forward mandibular positioning." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31973115.

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Wolfe, Jeremy Dean. "Vessel Formation and Feeder Vessel Treatment in Choroidal Neovascularization." University of Toledo Health Science Campus / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=mco1095878383.

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Kimura, Hideya. "A new model of subretinal neovascularization in the rabbit." Kyoto University, 1997. http://hdl.handle.net/2433/202230.

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Tressel, Sarah Lynne. "Role of shear stress in angiopoietin-2-dependent neovascularization:." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22646.

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Thesis (Ph. D.)--Biomedical Engineering, Georgia Institute of Technology, 2008.
Committee Chair: Jo, Hanjoong; Committee Member: McIntire, Larry; Committee Member: Nie, Shuming; Committee Member: Taylor, Robert; Committee Member: Weyand, Cornelia.

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Shum, Mei-yan Lily. "Neovascularization in the glenoid fossa during forward mandibular positioning." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25314130.

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Chan, Shuk-yee Annie. "Expression of angiogenic regulators in gliomas /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21451497.

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Miyamoto, Hideki. "Effect of Focal X-ray Irradiation on Experimental Choroidal Neovascularization." Kyoto University, 1999. http://hdl.handle.net/2433/181752.

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Crespo, García Sergio [Verfasser]. "Microglia in pathological neovascularization in the retina / Sergio Crespo García." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1126504270/34.

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Robinson, Scott Thomas. "Determining the role of endothelial progenitor cells in post-natal neovascularization." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/37178.

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Endothelial Progenitor Cells (EPCs) were first identified from human blood samples as a population of circulating mononuclear cells capable of displaying a mature endothelial cell phenotype in culture. Subsequent studies have established that EPCs arise from the bone marrow (BM) and incorporate into the endothelium at sites of blood vessel growth, suggesting a potential role for these cells in neovascularization. Furthermore, a decline in EPC count has been correlated to multiple vascular pathologies, indicating that EPC number could serve as a biomarker of cardiovascular disease. Unfortunately, due to the variability in techniques used for EPC isolation and identification, considerable heterogeneity exists within the population of cells commonly defined as EPCs. In order for the clinical potential of EPCs to be fully realized, thorough characterization of the BM-derived cell populations involved in neovascularization is required. The objective of our study was to determine the functional significance of circulating EPCs in postnatal vascular growth and repair. Two separate strategies were employed to achieve this objective. In the first, we attempted to generate a novel mouse model where the pool of bone marrow-derived endothelial precursors was drastically reduced or eliminated. Our overall approach was to deliver a "suicide" gene, under control of an endothelial cell-specific promoter, to bone marrow cells for use in bone marrow transplantation (BMT) experiments. Mice receiving BMTs would therefore lack the ability to deliver viable BM-derived EPCs to sites of neovascularization. Our central hypothesis for this study was that a reduction in EPC viability would hinder endogenous vascular repair mechanisms, thereby exacerbating cardiovascular disease. In the second strategy, we attempted to identify novel progenitor cell populations based on the transcriptional regulation of pro-angiogenic genes. Our overall approach was to transduce BM with a retrovirus containing a fluorescent reporter gene under control of pro-angiogenic promoters for use in transplantation experiments. Our central hypothesis for this study was that unique populations of BM-derived cells could be identified by expression of the fluorescent reporter gene directed by the Vascular Endothelial Growth Factor (VEGF), endothelial Nitric Oxide Synthase (eNOS) and Vascular Endothelial (VE) Cadherin promoters. The BMT strategy utilized to address our first hypothesis was unsuccessful due to the use of a truncated form of the pro-apoptotic Bax as our suicide gene target. A plasmid encoding GFP fused to the truncated Bax fragment (ΔN-Bax, consisting of amino acids 112-192 of the full length protein) was used in transfection experiments to assess ΔN-Bax function. The GFP:ΔN-Bax fusion protein formed distinct extranuclear aggregates (presumably due to mitochondrial translocation) but did not induce apoptosis in transfected cells. The ΔN-Bax fragment also did not induce cell death when targeted to endothelial cells with retoviral-mediated gene delivery or in a transgenic mouse setting. To address our second hypothesis, we generated retroviral vectors containing the fluorescent tdTomato reporter under control of the VEGF, eNOS and VE Cadherin promoters. Significant fluorescence was detected in cultured endothelial cells and ex vivo-expanded BM cells. Following transplantation of transduced BM cells into lethally irradiated recipient mice, we were able to identify circulating populations of tdTomato-positive cells using flow cytometry. With these results we have identified novel subpopulations of circulating BM-derived cells which may play a significant role in post-natal neovascularization in mice. Therefore, results acquired from these studies could lead to improved cell therapy techniques for treatment of vascular disease.

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Tanemura, Mai. "The role of estrogen and estrogen receptor β in choroidal neovascularization." Kyoto University, 2005. http://hdl.handle.net/2433/144767.

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Watanabe, Daisuke. "Transcription Factor Ets-1 mediates Ischemia- and VEGF-dependent Retinal Neovascularization." Kyoto University, 2004. http://hdl.handle.net/2433/147534.

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Kamizuru, Hiroshi. "Monoclonal antibody-mediated drug targeting to choroidal neovascularization in the rat." Kyoto University, 2003. http://hdl.handle.net/2433/148716.

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Kidd, Kameha Rae. "Angiogenesis and neovascularization in association with extracellular matrix protein modified biomaterials." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/279992.

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Synthetic biomedical implants are used to replace diseased tissues and organs. Unfortunately, these implants often fail due to a lack of biocompatibility and poor integration by the recipient. This implant failure is associated with the formation of an avascular fibrous capsule and chronic inflammatory response. Additionally, small diameter vascular grafts have complications associated with surface thrombogenenicity and intimal hyperplasia. Porous polymers are often incorporated in the construction of biomedical devices because they permit tissue integration and improved biocompatibility. While the inclusion of porosity has enhanced device performance, these devices still do not perform optimally. The incorporation of a vascular network in association with and within the pores of these materials is believed to improve tissue integration and long-term device function. Several approaches are actively being studied for their ability to stimulate new vessel growth, angiogenesis, as well as to improve the direct interaction of cells with material surfaces. The process of angiogenesis involves the coordinated involvement of both soluble and insoluble factors such as growth factors and cytokines, and extracellular matrix proteins respectively. Often, growth factors and cytokines are expressed by the inflammatory cells associated with the biomedical implants, but the microenvironment within the polymer remains unstable with respect to the presence of the appropriate extracellular matrix proteins. The overall hypothesis of this dissertation is that the reestablishment of an extracellular microenvironment on and within a porous polymer will provide the appropriate substrates for promoting angiogenesis and neovascularization of porous polymers. The results of the studies within this dissertation demonstrate that extracellular matrix modifications of commercially available expanded polytetrafluoroethylene (ePTFE) successfully promote new vessel growth in the tissue surrounding the implant, termed angiogenesis, and new vessel growth within the pores of the polymer, termed neovascularization. Furthermore, the extracellular matrix protein laminin 5 was determined to promote human microvessel endothelial cell adhesion to ePTFE as well as support angiogenesis and neovascularization when used as a surface modification of ePTFE. Based on these studies, the extracellular matrix protein, laminin 5, could be utilized in the tissue engineering of biomedical implant devices to promote increased new vessel integration and improve the long-term viability of these devices.

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Chan, Gallant Kar Lun. "Molecular studies of the vascular endothelial growth factor (Vegf-A) and VEGF-receptor (Flk-1) genes of grass carp /." access full-text access abstract and table of contents, 2005. http://libweb.cityu.edu.hk/cgi-bin/ezdb/thesis.pl?mphil-bch-b19887668a.pdf.

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Thesis (M.Phil.)--City University of Hong Kong, 2005.
"Submitted to Department of Biology and Chemistry in partial fulfillment of the requirements for the degree of Master of Philosophy" Includes bibliographical references (leaves 124-141)

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Lara-Castillo, Nuria Tombran-Tink Joyce. "Analysis of PEDF expression in a mouse model of retinal neovascularization and autocrine effects of PEDF on retinal cells." Diss., UMK access, 2006.

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Thesis (Ph. D.)--School of Pharmacy and School of Biological Sciences. University of Missouri--Kansas City, 2006.
"A dissertation in pharmaceutical sciences and molecular biology and biochemistry." Advisor: Joyce Tombran-Tink. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Oct. 31, 2007. Includes bibliographical references (leaves 193-234). Online version of the print edition.

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Andriu, Alexandra. "Evaluating the utility of αvβ3 integrin antagonists to detect and treat angiogenic tumour cells." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=240026.

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Tumour angiogenesis, the formation of new blood vessels within a tumour, is a hallmark of cancers, that allows them to grow beyond a critical size and to metastasize to other organs. As the key driver of tumour angiogenesis, αvβ3 integrin is both an established therapeutic target for anti-angiogenic drugs and a biomarker for imaging agents. Accurate detection of αvβ3 integrin in angiogenic tumours impacts patient prognosis and could report on therapy response. Over the last twenty years, novel αvβ3 integrin-targeted radiotracers have been developed for PET imaging of tumour angiogenesis. While most radiotracers have shown their utility as diagnostic tools, only a few focussed on evaluating response to treatment, partly due to complex biology of the integrin receptors. The aim of this project was the in-vitro biological testing of a novel αvβ3-targeted radiotracer, [3H]ZMPZAT71, and the corresponding unlabelled compound for targeted delivery of a cytotoxic drug, paclitaxel (PTX). Firstly, this piece of work involved validation of this radiotracer to assess expression of αvβ3 integrin. Secondly, [3H]ZMPZAT71 was investigated as a biomarker for assessing response to pharmacological inhibitors of cell signalling pathways. Thirdly, the targeting moiety (ZMPZAT71) conjugated with paclitaxel was studied for integrinmediated drug delivery. The results presented herein demonstrate that radiotracer binding to αvβ3 integrin is dependent not only on the expression levels, but also on the activation status of αvβ3 integrin. Furthermore, this piece of information was used to explain radiotracer binding in response to various pharmacological inhibitors of key cell signalling pathways. Additionally, the integrin-targeted chemotherapeutic exhibited selective cytotoxic effect, explained by enhanced apoptosis of cancer cells compared to PTX alone, together with anti-migratory and anti-invasive effects from the targeting moiety. This study provides valuable information about the molecular mechanisms regulated by αvβ3 integrin, supporting the development of integrin-targeted therapeutics and imaging.

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Harman, Katherine. "The role of neovascularization in tissue bridge formation prior to axonal regeneration." Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5419.

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Sydorchuk, L., P. Fomin, R. Sydorchuk, I. Sydorchuk, O. Plehutsa, and A. Sydorchuk. "Lipopolysaccharide induces neovascularization and immunosuppression, and must be considered as therapentic target." Thesis, «Targeted Therapies in Hepatologu» Worshop.- Abstract Book (Hannover, Germany, January 24-25, 2013). – P.36, 2013. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/7392.

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Esaki, Jiro. "Local sustained release of prostaglandin E1 induces neovascularization in murine hindlimb ischemia." Kyoto University, 2010. http://hdl.handle.net/2433/97947.

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Sakurai, Tomonori. "The development of new immunoisolatory devices possessing the ability to induce neovascularization." Kyoto University, 2004. http://hdl.handle.net/2433/147453.

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Yang, Tianxiang. "Influence of chronic intermittent hypoxia (CIH) in retinal neovascularization and vascular remodeling." Electronic Thesis or Diss., Sorbonne université, 2024. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2024SORUS059.pdf.

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Les rétinopathies néovasculaires et les œdèmes sont des complications menaçant la vue des rétinopathies ischémiques, telles que la rétinopathie du prématuré (ROP) et la rétinopathie diabétique (DR). L'apnée du sommeil qui conduit à une hypoxie chronique intermittente (CIH) est un facteur de risque indépendant de maladie grave, mais les mécanismes sous-jacents sont inconnus. Nous montrons ici que le CIH expérimental pendant la phase ischémique de la rétinopathie induite par l'oxygène chez la souris réduit considérablement la revascularisation bénéfique de la rétine ischémique et augmente la perte neuronale et la néovascularisation pathologique. Mécaniquement, nous démontrons que le CIH réduit à la fois l'expression du facteur de stimulation des colonies 1 (CSF-1) et l'augmentation induite par l'ischémie des cellules microgliales rétiniennes qui favorisent la revascularisation de la rétine ischémique en l'absence de CIH. L'inhibition locale du CSF1R au cours de la rétinopathie ischémique a réduit le nombre de cellules microgliales, inhibé la revascularisation et exacerbé la néovascularisation pathologique, récapitulant plusieurs effets du CIH. Nos résultats fournissent un nouveau mécanisme par lequel l'apnée du sommeil et le CIH aggravent les rétinopathies ischémiques, soulignant l'importance du traitement de l'apnée dans la ROP et la RD pour aider à prévenir une maladie grave menaçant la vue
Neovascular retinopathies and edema are sight threatening complications of ischemic retinopathies, such as retinopathy of prematurity (ROP) and diabetic retinopathy (DR). Sleep apnea that leads to chronic intermittent hypoxia (CIH) is an independent risk factor for severe disease, but the underlying mechanisms are unknown. Here we show that experimental CIH during the ischemic phase of oxygen induced retinopathy in mice severely reduces beneficial revascularization of the ischemic retina, and increases neuronal loss and pathological neovascularization. Mechanistically we demonstrate that CIH reduces both colony stimulating factor 1 (CSF-1) expression and the ischemia-induced increase of retinal microglial cells that promotes the revascularization of the ischemic retina in the absence of CIH. Local CSF1R inhibition during ischemic retinopathy reduced the number of microglial cells, inhibited revascularization, and exacerbated pathological neovascularization, recapitulating several effects of CIH. Our findings provide a novel mechanism by which sleep apnea and CIH aggravate ischemic retinopathies, underscoring the importance of treating apnea in ROP and DR to help prevent sight threatening severe disease

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Lee, Kai-chung Arthur, and 李啓聰. "The prognostic significance of lymphatic and blood vessel invasion, angiogenesis and occult nodal metastasis in breast carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1995. http://hub.hku.hk/bib/B31981604.

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陳淑儀 and Shuk-yee Annie Chan. "Expression of angiogenic regulators in gliomas." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31222274.

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The Best M.Phil Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize,1997-1999
published_or_final_version
Pathology
Master
Master of Philosophy

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Li, Chengyong, and 李成永. "Total syntheses (-)-5-demethoxyfumagillol, (-)-fumagillol, (-)-RK-805,(-)-FR65814, and analogues." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39793977.

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Liu, Xingguo, and 刘兴国. "Concise synthesis of racemic and chiral fumagillol via intramolecular carbonyl ene reaction." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46588292.

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Fox, Stephen B. "Angiogenesis in human cancer." Thesis, University of Oxford, 1996. http://ora.ox.ac.uk/objects/uuid:da4c4e35-7203-4efe-8716-109b5b1c4941.

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Angiogenesis is the formation of new vessels from existing vasculature and is essential for tumour growth and metastasis. It is controlled by angiogenic factors secreted by the tumour which regulate the matrix remodelling, endothelial cell (EC) proliferation, and capillary differentiation necessary for establishing a blood supply. This thesis has examined angiogenesis in human tumours. Immunohistochemically highlighted vessels in tumours were quantified using different methods to develop a rapid and objective method for measuring tumour angiogenesis. Significant associations between Chalkley counting, microvessel density, vascular area and perimeter were demonstrated; the Chalkley technique gave independent prognostic information and was suitable for a diagnostic service. Studies on the frequency EC of S-phase showed proliferation (labelling index 2.2%) occurs mostly at the tumour margin suggesting the growth factors controlling ECs are different from those regulating tumour cells and that remodelling the existing vasculature might play a more important role than previously recognised. To investigate further ECtumour matrix interactions, the expression of cell adhesion molecules (CAMs) was examined. CAM expression mirrored that of EC proliferation with preferential expression on endothelium at the tumour periphery: expression of CAMs was also present on neoplastic cells. Thus, acquisition of CAMs by tumour cells together with EC phenotypic modulation might promote angiogenesis and metastasis. The angiogenic factor thymidine phosphorylase (TP) was examined in normal tissues and tumours. Although TP was expressed in ECs there was no correlation between expression in normal or neoplastic tissue and vascularity. Nevertheless, TP was elevated in small low grade tumours, in accordance with TP being chemotactic but non-mitogenic for ECs. A monoclonal antibody to flt-4, a candidate angiogenic factor receptor was generated and characterised. In contrast to the in-situ mRNA expression profile, a restricted pattern of protein expression was observed in normal tissues and variable expression in tumours.

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Corrêa, de Sampaio Pedro Vaz de Almada. "Using a novel 3-dimensional in vitro spheroid model to investigate new roles for stromal metalloproteinases in tumour angiogenesis." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610640.

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Cunha, Filipa. "Controlling angiogenesis electrically?" Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=232613.

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Physiological electrical fields (EFs) can direct some important angiogenic responses of endothelial cells such as directional migration, orientation and proliferation. It has been reported that human umbilical vein endothelial cells (HUVEC) and human microvasculature endothelial cells (HMEC) migrate in opposite directions; to anode and cathode, respectively. Although, in the present study both cell types migrated toward the cathode, HUVEC directedness started at 50mV/mm while HMEC directedness started at 100mV/mm. These results suggest that EFs can promote wound healing by directing endothelial cells to the wound site since EFs of 40 to 100 mV/mm are present in normal healing wounds. EFs also increased cell proliferation and orientated the cleavage plane of dividing cells perpendicular to the EF vector in both endothelial cell lines. The present study showed for the first the time that EFs upregulated the expression of the chemokine receptors CXCR4 and CXCR2 as well as upregulating the levels of phosphorylation of both chemokines in HUVEC and HMEC. It also showed differences of chemokine receptors used by HUVEC and HMEC cells in the early stages of electrotaxis. Ionizing radiation has been shown to directly phosphorylate VEGF receptors in the absence of its ligand VEGF. A question was raised: in the absence of the ligands are EFs able to directly phosphorylate the chemokine receptors? Results showed that in starved HUVEC cells EFs had no effect on the phosphorylation levels of CXCR4 and CXCR2 however in starved HMEC cells an EF may have a direct effect on the phosphorylation levels of CXCR4 and CXCR2. Therefore, EFs represent a physical stimulus that could directly phosphorylate proteins in the absence of its ligand. This work substantiate the importance of endogenous EFs in directing endothelial cells and suggests that EFs might be developed as a component in the clinic to control angiogenesis.

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Liu, Tiffany. "The role of macrophage chemoattractant signaling in cancer cell migration, metastasis and neovascularization." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p1476514.

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Afzal, Aqeela. "Reduction in pre-retinal neovascularization by ribozymes that cleave the A2B receptor mRNA." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000624.

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Hunter, William Lawrence. "Neovascularization into the epiphyseal growth plate : a morphological study of the metaphyseal vessels." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27479.

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The metaphyseal vessels which invade the calcified cartilage of the epiphyseal growth plate were examined by a variety of techniques to determine their morphology, replicative dynamics and growth patterns as they relate to endochondral ossification. For descriptive purposes four different regions of these vessels were characterized: 1) Sprout Tips - the terminal ends of the capillary sprouts which actually impinge upon the hypertrophic chondrocytes of the growth plate. 2) Region of Extended Calcified Cartilage - those vessels deeper within the metaphysis which are surrounded by an extracellular matrix predominantly composed of extended septa of calcified cartilage. 3) Region of Bone Deposition - further still from the epiphyseal cartilage the microvessels are contained within a network of active bone deposition laid down upon a calcified cartilage framework. 4) Region of Primary Vessels - at a distance of 350-500 μm from the hypertrophic chondrocytes are dilated vessels with one or two layers of smooth muscle in their walls, that supply and drain the metaphyseal capillary plexus. Electron microscopic examination following perfusion fixation at physiological conditions of pressure and flow rate with either 2.3% glutaraldehyde alone or mixed with 2% tannic acid, demonstrated several ultrastructural features. The sprout tips of the metaphyseal capillaries are continuous blind-ended vessels lined by an attenuated fenestrated endothelium with no underlying basement membrane. Progressing deeper into the metaphysis, an abluminal basement membrane-like material is found in regions adjacent to the endothelial cell nucleus but not beneath more attenuated portions of the cell. Upon reaching the region of bone deposition, a more complete basement membrane is present and covers an increasingly larger percentage of the abluminal cell surface; although it is never entirely continuous. Dividing endothelial cells are most frequently found in the region of bone deposition at an average of 175-200 μm behind the apicies of the growing sprout tips. Serial sections revealed that dividing endothelial cells retain junctional attachments to neighbouring cells of the capillary wall throughout mitosis. The cells also form microvillar adhesion sites between daughter cells (and adjacent cells) prior to the completion of cytokinesis, such that they are junctionally linked before dissolution of the cell bridge. Unlike many angiogenic vessels, in the metaphyseal capillaries endothelial cell division occurs at a location where circulatory flow has already been established, and it must produce the cells necessary for continued growth while maintaining an intact vascular wall. Throughout the metaphyseal sprouts the endothelial cells display many features associated with growing vessels including luminal microvilli, abluminal cellular projections, and abundant cytoplasmic organelles. Dividing pericytes are characteristically found distributed evenly between the regions of extended calcified cartilage and bone deposition (50-350 μm from the sprout tip). The capillaries and post-capillary venules which act as the parent vessels from which the metaphyseal capillaries are derived are thought to be located within the region of bone deposition near their union with the larger primary vessels (250-350 μm from the sprout apecies). The metaphyseal capillary sprouts represent a continuous unidirectional angiogenic vascular network which grows via a constant radiating elongation from a growth centre that remains a fixed distance behind the growth front.
Medicine, Faculty of
Graduate

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42

Wakazono, Tomotaka. "RECURRENCE OF CHOROIDAL NEOVASCULARIZATION LESION ACTIVITY AFTER AFLIBERCEPT TREATMENT FOR AGE-RELATED MACULAR DEGENERATION." Kyoto University, 2018. http://hdl.handle.net/2433/232093.

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43

Kimura, Tetsushi. "Comparisons between the beneficial effects of different sulphonylurea treatments upon ischemia-induced retinal neovascularization." Kyoto University, 2008. http://hdl.handle.net/2433/124212.

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Krenning, Guido. "Endothelial progenitor cells in vascular regenerative medicine towards 'designer blood vessels' and 'therapeutic neovascularization' /." [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/.

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Wendt, Gunvor von. "Screening for diabetic retinopathy : aspects of photographic methods /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-398-1/.

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Tanenbaum, Michael David. "Control of angiogenic responses through an evolutionary conserved sequence of fibroblast growth factor." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/20209.

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Ma, Li. "The influence of nicotine on angiogenesis and osteogenesis in bone regeneration." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508440.

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Garton, Rosemary Louise. "The influence of basement membrane proteins on re-vascularization networks formed after acute injury." Thesis, The University of Sydney, 1997. http://hdl.handle.net/2123/4817.

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Li, Hong. "Studies of VEGF-B and novel PDGFs in tumorigenesis and angiogenesis /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-815-7/.

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Anderson, Erin Michelle. "Endothelial Progenitor Cell Recruitment for Therapeutic Neovascularization using Alginate Hydrogels for VEGF and SDF Delivery." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11330.

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Abstract:

Endothelial progenitor cells are potentially useful as a cell therapy for the treatment of ischemic cardiovascular diseases, but clinical outcomes have been limited likely because very few systemically delivered cells reach the target tissue. Biomaterials may improve outcomes of endothelial progenitor-based therapies because they can generate well-defined microenvironments capable of directing cell behavior. The hypothesis guiding this thesis is that local, sustained delivery of exogenous Vascular Endothelial Growth Factor (VEGF) and Stromal Cell-Derived Factor (SDF) from alginate hydrogels can enhance recruitment of endothelial progenitors to ischemic sites and also promote their contribution to new blood vessel growth.
Engineering and Applied Sciences

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Dissertations / Theses on the topic 'Neovascularization'

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