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Ali Naqvi, Syed Muhammad. "Frequency and pattern of salivary gland lesions at a tertiary care centre." Isra Medical Journal 14, no. 2 (June 30, 2022): 50–54. http://dx.doi.org/10.55282/imj.oa1279.
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Objective: To analyze the frequency and histo-morphological pattern of non-neoplastic and neoplastic salivary gland lesions at a tertiary care centre. Study Design: Retrospective descriptive cross-sectional study Place and Duration: Histopathology section, Dow Diagnostic Reference and Research Laboratory, Karachi from 1st February 2021 to 31st July, 2021. Methodology: Data of all salivary gland lesions were retrieved from institutional database. All tissue specimens of parotid, submandibular and sublingual salivary glands lesions as well as possible minor salivary glands swellings were included for histopathological analysis. Type of benign or neoplastic lesion along with salivary gland involved were assessed. Results: Out of a total of 739 samples, 28.0% were non-neoplastic whereas 72.0% were neoplastic lesions. Out of 207 non-neoplastic lesions, 55.1% were of inflammatory origin whereas 44.9% were mucoceles. Chronic sialadenitis (61.4%) was the most common non-neoplastic inflammatory lesion. Among mucoceles, those reported with no specification of type predominated (37.6%). Out of total 543 neoplastic lesions, 53.1% were benign whereas 19.3% were malignant. Pleomorphic adenoma (87.1%) was the commonest benign neoplastic lesion, followed by benign epidermal inclusion cysts (3.7%). Of the 127 malignant salivary gland tumors, mucoepidermoid carcinoma (39.4%) was the most common lesion, followed by adenoid cystic carcinoma (29.1%). Conclusion: Chronic sialadenitis was the most common non-neoplastic lesion whereas pleomorphic adenoma was the predominant benign lesion. Moreover, mucoepidermoid carcinoma was the most common malignant lesion followed by adenoid cystic carcinoma. Keywords: Salivary Glands, Neoplastic lesion, Non-neoplastic lesion, Frequency, Sialadenitis, Adenoma, Carcinoma
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Singh, Mrinalini, KK Jha, SU Kafle, R. Rana, and P. Gautam. "Histopathological Analysis of Neoplastic and Non-Neoplastic Lesions of Ovary : A 4 Year Study in Eastern Nepal." Birat Journal of Health Sciences 2, no. 2 (November 2, 2017): 168–74. http://dx.doi.org/10.3126/bjhs.v2i2.18519.
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IntroductionOvarian neoplastic and nontineoplastic lesions form a pelvic mass and cause gynaecological problems. Therefore, proper recognization and classification is important for appropriate therapy.ObjectiveTo study the morphological patiern and classify the neoplastic and nontineoplastic ovarian lesions in terms of age and size.MethodologyA retrospective study conducted at Sriram Diagnostic Clinic, Biratnagar, Nepal and Birat Medical College, Tankisinwari, Morang, Nepal during a period of March 2012 to February 2016. All abdominal hysterectomy specimens with bilateral or unilateral salpingo-oophorectomy and all ovarian surgeries presenting with either solid or cystic ovarian lesions were included in the study for histopathological analysis. Normal appearing ovaries on gross and microscopic examination were excluded from the study.ResultsA total of 522 cases were studied. Out of which 329 (63%) were non-neoplastic and 193 (37%) were neoplastic. Follicular cysts comprised of 112 (34%) cases, and it was the most common non neoplastic lesion. The age of patients with non-neoplastic lesions and neoplastic lesions varied from 16-54 years and 13-72 years respectively. Size of nonneoplastic and neoplastic lesions varied from 2-12 cm and 2- 19 cm respectively. Among the 193 neoplastic ovarian lesions, 181 (94 %) were benign, as well as 4 (2%) were borderline and 8 (4 %) were malignant. Mature cystic teratoma was the commonest benign tumor followed by Serous cystadenoma. Serous cystadenocarcinoma was the commonest occurring malignant tumor followed by Mucinouscystadenocarcinoma.ConclusionVarying types of both non neoplastic and neoplastic ovarian lesion were seen. Among the non-neoplastic and neoplastic lesion, the most commonly encountered lesion was follicular cyst and mature cystic teratoma respectively.Birat Journal of Health SciencesVol.2/No.1/Issue 2/ Jan - April 2017, Page: 168-174
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Cassinotti, Andrea, Paolo Fociani, Piergiorgio Duca, Manuela Nebuloni, Sophia Elizabeth Campbell Davies, Gianluca Sampietro, Federico Buffoli, Alberto Corona, Giovanni Maconi, and Sandro Ardizzone. "Modified Kudo classification can improve accuracy of virtual chromoendoscopy with FICE in endoscopic surveillance of ulcerative colitis." Endoscopy International Open 08, no. 10 (September 22, 2020): E1414—E1422. http://dx.doi.org/10.1055/a-1165-0169.
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Abstract Background and study aims Virtual chromoendoscopy with Fuji Intelligent Color Enhancement (FICE) has never been studied in prospective trials of endoscopic surveillance for ulcerative colitis (UC). We compared FICE and white light endoscopy (WLE) in differentiation of visible lesions in UC. Patients and methods In a prospective parallel study, we compared consecutive outpatients with UC submitted to surveillance colonoscopy with FICE or WLE. At least one visible polypoid or non-polypoid lesion for each patient was required. Random biopsies from normal mucosa, targeted biopsies or removal of suspected neoplastic lesions and targeted biopsies of unsuspected lesions were performed. In the FICE arm, neoplasia was suspected according to a modified Kudo classification (FICE-KUDO/inflammatory bowel disease [IBD]). Sensitivity (SE), specificity (SP), positive and negative likelihood ratios (LR) and negative predictive value (NPV) were analyzed. Results One hundred patients were submitted to FICE (n = 46) or WLE (n = 54). Twenty-two patients (11 in WLE, 11 in FICE) had a least one neoplastic lesion. No neoplasia was found in random biopsies. Among 275 lesions, 17 of 136 by FICE and 27 of 139 by WLE were suspected neoplasia, but 28 (14 in each arm) were true neoplastic lesions. The accuracy of FICE-KUDO/IBD vs WLE (per lesion) was: SE 93 % vs 64 % (P = 0.065), SP 97 % vs 86 % (P = 0.002), positive-LR 28.3 vs 4.5 (P = 0.001), negative-LR 0.07 vs 0.42 (P = 0.092), NPV 99 % vs 96 % (P = 0.083). FICE-KUDO/IBD detected more non-polypoid lesions than WLE (P = 0.016). Conclusions Targeted biopsies of polypoid and non-polypoid lesions, using the modified Kudo classification with FICE are more accurate than WLE in UC surveillance.
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Gupta, Urvashi, Ruchi Shrestha, Ashok P. Samdurkar, and Anita Shahi. "A Histopathological Study of Neoplastic Lesions of Conjunctiva." Journal of Universal College of Medical Sciences 4, no. 1 (January 24, 2018): 32–35. http://dx.doi.org/10.3126/jucms.v4i1.19077.
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BACKGROUND: Ocular malignant tumors are relatively rare compared to other eye lesions, require immediate diagnosis and management. But ignorant care due to unawareness of persons can result into debility, loss of vision, and occasionally life is jeopardized.1 The aim of the study is to determine the frequency of most common neoplastc lesions of conjunctiva with histopathologically confirmed diagnosis. MATERIAL AND METHODS: It was a retrospective cross-sectional study done in a period of two years (January 2011 December 2012) that included120 patients who presented with conjunctival lesions to the pathology department of Universal College of Medical Science, Bhairahawa, Nepal. RESULTS: In this study out of 120 biopsies which were histopathologically diagnosed as conjunctival neoplasms were categorized into benign, dysplastic and malignant lesion and was common after second decade of life. Majority of cases (75 cases, 62.5%) were categorized as benign lesion with predominance of squamous papilloma (n=25) and nevus (n=21), followed by malignant lesion (27 cases, 22.5%) and dysplastic lesions (18 cases, 15%). Amongst malignancies, squamous cell carcinoma (SCC) was the most prevalent and a case of malignant melanoma was studied. Dysplastic lesion included conjunctival intraepithelial neoplasia (CIN) with and without squamous papilloma. CONCLUSION: Histopathology plays an important role in diagnosis of conjunctival lesions and rules out different categories of neoplastic lesions on routine basis. In this study Squamous cell carcinoma (SCC) 20.01% is the most common malignant tumor of conjunctiva. The next majority of cases diagnosed as the verrucuous carcinoma 1.66% and malignant melanoma 0.83% maximum case of malignant cases diagnosed in the age group of more than 50 years. Journal of Universal College of Medical Sciences (2016) Vol.04 No.01 Issue 13, Page: 32-35
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Dhawle, Manjusha, Ashwini Tangde, Anil Joshi, and Rajan Bindu. "Clinicopathological study of testicular lesions." International Journal of Research in Medical Sciences 7, no. 4 (March 27, 2019): 1319. http://dx.doi.org/10.18203/2320-6012.ijrms20191346.
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Background: Testis is affected by both neoplastic and non neoplastic conditions. Non neoplastic lesions of the testis include epididymo-orchitis, testicular atrophy, undescended testis, testicular abscess etc. Testicular tumors are relatively rare. They constitute the 4th most common cause of death from neoplasia in the young males. This study was undertaken to study the histopathological spectrum, age wise distribution and clinical symptoms of testicular lesions.Methods: This is a retrospective study of three years conducted in the department of pathology, Aurangabad from June 2015 to May 2018. It included all the orchidectomy specimens received from the department of surgery and excluded the orchidectomy specimens sent for infertility and prostatic carcinoma. A detail clinical history was taken. Histopathological examination was done after routine processing and staining with H and E. The data collected was tabulated, analysed and compared to other similar studies.Results: We studied 70 cases. Non neoplastic testicular lesions were 57 and 13 were neoplastic. Non neoplastic testicular lesions were more common than the neoplastic ones. Non neoplastic testicular lesions presented most commonly in the 2nd decade. Most common non neoplastic lesion was epididymo-orchitis followed by torsion, atrophy and testicular abscess. Most common neoplasm was malignant mixed germ cell tumor. Most of the patients of neoplasms presented in the 3rd decade. The most common complaint was testicular swelling and pain.Conclusions: Majority of testicular lesions are non neoplastic. Neoplastic lesions are rare. Non neoplastic lesions mimic neoplastic ones clinically, as testicular swelling is the most common complaint. So histopathological diagnosis is necessary for an accurate diagnosis of testicular lesions.
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Kedarisetty, Vidya. "Spectrum of esophageal lesions- A study of endoscopic biopsies." IP Journal of Diagnostic Pathology and Oncology 6, no. 2 (June 15, 2021): 127–31. http://dx.doi.org/10.18231/j.jdpo.2021.027.
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Endoscopic biopsies is a very common outpatient procedure in gastroenterology unit. The present article is a study of endoscopic biopsies taken from the esophagus. The gastrointestinal tract cannot be visualized directly and endoscopy is a very important and easy tool for visualization of GI tract lesions directly and helping in the diagnosis in the early stage, there by helping in the overall well being of the patient. To emphasize the utility of endoscopic biopsies in the diagnosis of esophageal lesions. To correlate the endoscopic findings with pathological diagnosis. To study the various pathologies. Endoscopic biopsies taken from the esophagus were studied and analysed in the present study. The biopsies are taken by the gastroenterologist. The biopsies are fixed in 10%formalin.After fixation the biopsy specimen is processed and embedded in paraffin.4 to 5 microns thick sections were cut, stained with Haematoxylin & Eosin and studied. Out of the 118 cases of esophageal biopsies received at the Department of Pathology, Mediciti Institute of Medical Sciences from December 2016 to November, 2018. ,50 were non neoplastic lesions, 68 cases were neoplastic lesions, 50 were non neoplastic lesions, 68 cases were neoplastic lesions. Chronic non specific esophagitis was the commonest non neoplastic esophageal lesion. Squamous cell carcinoma was the commonest neoplastic lesion. The lower one third is the commonest site of pathology for esophagus. Males are mostly effected and predominant age of presentation is around 40-60 years for non neoplastic lesion and 50-70 years for neoplastic region.
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Sawant, Amod, and Suresh Mahajan. "Histopathological Study of Ovarian Lesions at a Tertiary Health Care Institute." MVP Journal of Medical Sciences 4, no. 1 (May 22, 2017): 26. http://dx.doi.org/10.18311/mvpjms/0/v0/i0/724.
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Background: Ovary is the commonest site of neoplastic and nonneoplastic lesion, can present in childhood to postmenopausal age group and accounts for the most prevalent cause of hospital admissions. Aim: This study was done to analyse the frequency of ovarian lesions their histological features in a tertiary health care centre. Materials and Methods: This is a prospective study of 143 ovarian lesions at tertiary care hospital over a period of 3yr. All the relevant data of patients analysed from hospital record file. Results: The total number of ovarian lesions studied during study period was 143 cases, amongst them 110 were non-neoplastic and remaining 33 were neoplastic. The most common non-neoplastic lesion seen was solitary follicular cysts i.e. 77 cases (70%), followed by corpus luteal cysts 14 cases (12.7%). Among the 33 neoplastic ovarian lesions 25(75.7%) cases were benign, 2(6.1%) case was at borderline and 6 (18.2%) cases were malignant. In benign ovarian neoplasm, most commonly seen lesion were serous cystadenoma followed by benign cystic teratoma. In malignant cases, maximum were of serous cystadenocarcinoma, followed by endometrioid carcinoma and 2 cases of sex-cord stromal tumours (fibromas) were observed metastatic tumours. Conclusion: Ovarian lesion possess wide gamut of histology. Specific diagnoses are made on routine gross and histological examination.
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Sudiono, Janti, Barnabas Howuk, and Cindy Fransisca. "Macrophage and angiogenesis intensity within proliferative non neoplastic and neoplastic oral lesions." Padjadjaran Journal of Dentistry 30, no. 3 (November 30, 2018): 215. http://dx.doi.org/10.24198/pjd.vol30no3.16851.
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The most common chronic inflammation involved dental and oral tissue is gingival polyp, pulp polyp, and fibroma that are proliferative non neoplastic and neoplastic condition. Chronic inflammation will induce cells and vascular proliferation as well as biological nature lesion. Previous study revealed that increase macrophage followed by increase angiogenesis intensity. Increase angiogenesis or vascular proliferation indicates progressive growth in form of proliferative non neoplastic or neoplastic disease outside of their easily bleeding clinical features. This study evaluated macrophage and angiogenesis intensity and their correlation within such oral lesions. Samples used are of oral mucosa excision with clinical diagnose of gingival polyp (n=3); pulp polyp (n=3); and fibroma (n=3). Macrophage was detected using immunostaining with CD68 antibody resulted in brown staining cell membrane under light microscope while angiogenesis intensity evaluated as number of blood vessels. The results showed there was mild positive correlation of angiogenesis intensity and CD68+ as macrophage marker with r=0.31. The angiogenesis intensity showed significant differences (p<0.05) with the highest was in pulp polyp (12.00) followed by fibroma (11.81) and gingival polyp (9.67), however there was no significant difference between non neoplastic lesion (pulp polyp) and neoplastic lesion (fibroma). The CD68+ expression showed no significant differences (p=0.102>0.05) with the highest was in fibroma (51.32±31.64%) followed by non neoplastic pulp polyp (45.82±15.94%) and gingival polyp (29.98±13.51%). This result was in accordance with the biological properties of lesions from the aspect of angiogenesis and macrophage intensity that can be used as parameter for determining the growth and prognosis of lesion.
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Bisschops, Raf, Talat Bessissow, Joseph A. Joseph, Filip Baert, Marc Ferrante, Vera Ballet, Hilde Willekens, et al. "Chromoendoscopy versus narrow band imaging in UC: a prospective randomised controlled trial." Gut 67, no. 6 (July 11, 2017): 1087–94. http://dx.doi.org/10.1136/gutjnl-2016-313213.
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BackgroundPatients with long-standing UC have an increased risk for the development of colonic neoplastic lesions. Chromoendoscopy (CE) has been proven to enhance neoplasia detection while the role of virtual chromoendoscopy (VC) is still to be defined.ObjectiveTo compare the performance of CE to VC for the detection of neoplastic lesions in patients with long-standing UC.DesignA multicentre prospective randomised controlled trial. 131 patients with long-standing UC were randomised between CE with methylene blue 0.1% (n=66) or VC with narrow band imaging (NBI) (n=65). Biopsies were taken from visible lesions and surrounding mucosa. No random biopsies were performed. The primary outcome was the difference in total number of neoplastic lesions detected in each group.ResultsThere was no significant difference between NBI and CE for neoplasia detection. Mean number of neoplastic lesions per colonoscopy was 0.47 for CE and 0.32 for NBI (p=0.992). The neoplasia detection rate was not different between CE (21.2%) and NBI (21.5%) (OR 1.02 (95% CI 0.44 to 2.35, p=0.964). Biopsies from the surrounding mucosa yielded no diagnosis or dysplasia. The per lesion neoplasia detection was 17.4% for CE and 16.3% for NBI (OR 1.09 (95% CI 0.59 to 1.99, p=0.793). The total procedural time was on average 7 min shorter in the NBI group.ConclusionCE and NBI do not differ significantly for detection of colitis-associated neoplasia. Given the longer withdrawal time for CE and easier applicability, NBI may possibly replace classical CE.Trial registration numberNCT01882205; Results.
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Bal Gargade, Chitrawati, Archana Hemant Deshpande, and Seetu Palo. "Histopathological spectrum of vulvar lesions on a remote Indian Island." IP Archives of Cytology and Histopathology Research 6, no. 3 (September 15, 2021): 153–59. http://dx.doi.org/10.18231/j.achr.2021.037.
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A wide spectrum of normal, benign, premalignant, and malignant lesions may occur on the vulva. Symptoms of vulvar disorders may be non-specific. Empiric treatment of vulvovaginal symptoms is common but usually not helpful. Though the varied clinical presentation and diverse histopathological spectrum of vulvar lesions have amazed Pathologists, only a few studies have been reported in the literature. The present study consists of a histopathological spectrum of vulvar lesions. 1.To evaluate the histopathological spectrum of vulvar lesions. 2. To compare the incidences of non-neoplastic and neoplastic lesions of the vulva. Present study includes all types of vulvar lesion specimens received in the Department of pathology over a period of four years. All thirty-nine vulvar biopsies received in the Department of Pathology were studied for histomorphologic features. The lesions were categorized as non-neoplastic, neoplastic. The neoplastic ones were further divided into benign, malignant, and premalignant. The age of the women ranged from 15 to 69 years (mean 36.18±12.71) with the maximum number of patients between 30 to 40 years of age. Non neoplastic lesions were more common (22; 56.4%) than the (17; 43.6%) neoplastic lesions. There were 15(38.5%) benign lesions while 2 cases (5.13%) were malignant. Among the non-neoplastic lesions, Bartholin's duct cyst was the most common histopathologic diagnosis (35.9%). The fibroepithelial polyp was the most common benign neoplastic lesion constituting 15.3%. In the present study nonneoplastic lesions were more common than neoplastic lesions. Among the neoplastic lesions, benign neoplasms were more frequent than malignant lesions.
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Ranabhat, S., M. Tiwari, S. Maharjan, A. Bhandari, M. Subedi, and B. P. Osti. "Histopathologic spectrum of cystic ovarian masses." Journal of Chitwan Medical College 6, no. 1 (February 16, 2017): 16–20. http://dx.doi.org/10.3126/jcmc.v6i1.16574.
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This research was a cross sectional analytic observational histopathological study of cystic ovarian lesions carried out over three years from March, 2012 to February, 2015 at Chitwan Medical College Teaching Hospital in Nepal. The objective of this study was to study cystic ovarian masses histopathologically. A total of one hundred and fourteen patients with cystic ovarian masses were included into the study. 46.5% lesions were non-neoplastic (83% physiologic and 17% pathologic) and 53.5% lesions were neoplastic (91.8% benign and 8.2% malignant). Follicular cyst was the most common ovarian cystic lesion overall, followed by mature cystic teratoma and serous cystadenoma. 14.9% of all the ovarian cysts had undergone torsion; among them mature cystic teratoma was the most common lesion to have undergone the complication. Neoplastic ovarian cysts were more common than non-neoplastic. Follicular cyst was the most common ovarian cyst overall. Mature cystic teratoma was the ovarian cystic lesion to be affected by torsion most commonly.
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de Godoy Fernandes, Giovana, Bruna Pedrina, Patrícia de Faria Lainetti, Priscila Emiko Kobayashi, Verônica Mollica Govoni, Chiara Palmieri, Veridiana Maria Brianezi Dignani de Moura, Renée Laufer-Amorim, and Carlos Eduardo Fonseca-Alves. "Morphological and Molecular Characterization of Proliferative Inflammatory Atrophy in Canine Prostatic Samples." Cancers 13, no. 8 (April 14, 2021): 1887. http://dx.doi.org/10.3390/cancers13081887.
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Proliferative inflammatory atrophy (PIA) is an atrophic lesion of the prostate gland that occurs in men and dogs and is associated with a chronic inflammatory infiltrate. In this study, we retrospectively reviewed canine prostatic samples from intact dogs, identifying 50 normal prostates, 140 cases of prostatic hyperplasia, 171 cases of PIA, 84 with prostate cancer (PC), 14 with prostatic intraepithelial neoplasia (PIN) and 10 with bacterial prostatitis. PIA samples were then selected and classified according to the human classification. The presence of PIA lesions surrounding neoplastic areas was then evaluated to establish a morphological transition from normal to preneoplastic and neoplastic tissue. In addition, the expression of PTEN, P53, MDM2 and nuclear androgen receptor (AR) were analyzed in 20 normal samples and 20 PIA lesions by immunohistochemistry and qPCR. All PIA lesions showed variable degrees of mononuclear cell infiltration around the glands and simple atrophy was the most common histopathological feature. PIA was identified between normal glands and PC in 51 (61%) out of the 84 PC samples. PIA lesions were diffusely positive for molecular weight cytokeratin (HMWC). Decreased PTEN and AR gene and protein expression was found in PIA compared to normal samples. Overall, our results strongly suggest that PIA is a frequent lesion associated with PC. Additionally, this finding corroborates the hypothesis that in dogs, as is the case in humans, PIA is a pre neoplastic lesion that has the potential to progress into PC, indicating an alternative mechanism of prostate cancer development in dogs.
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Selmic, Laura E., Carolyn L. Chen, Janis Lapsley, Page Yaxley, Megan Brown, Vincent A. Wavreille, and Giovanni Tremolada. "Retrospective Study Evaluating Surgical Treatment and Outcome in Dogs with Septic Peritonitis Secondary to Neoplasia." Journal of the American Animal Hospital Association 59, no. 2 (February 28, 2023): 85–94. http://dx.doi.org/10.5326/jaaha-ms-7306.
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ABSTRACT Septic peritonitis is a life-threatening disease that can be caused by neoplasia, among other disease processes. There is no veterinary literature directly evaluating the outcome of patients with septic peritonitis caused by neoplasia. The objective of this study was to evaluate for differences in survival to discharge and complication rates between septic peritonitis caused by neoplastic and nonneoplastic disease in canine patients. A single-institution retrospective cross-sectional cohort study was performed, identifying dogs that were treated surgically for septic peritonitis between January 1, 2010, and November 1, 2020. A total of 86 patients were included, 12 with a neoplastic cause for septic peritonitis and 74 with another cause. The most common neoplastic lesions associated with septic peritonitis were gastrointestinal lymphoma and hepatocellular adenoma. Presence of neoplasia was not a significant factor for development of intraoperative or immediate postoperative complications, nor did it decrease chances of survival to discharge (P < .09). The diagnosis of a primary, localized, neoplastic lesion alone should not deter clinicians and owners from pursuing treatment for septic peritonitis.
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Parmar, Nisha Jayantilal, Deepa P. Jethwani, and Gauravi A. Dhruva. "Histopathological study of nasal lesions: 2 years study." International Journal of Research in Medical Sciences 6, no. 4 (March 28, 2018): 1217. http://dx.doi.org/10.18203/2320-6012.ijrms20181271.
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ackground: Majority of the nasal lesions are polypoid. It is difficult to comment upon the nature of the nasal lesion- whether neoplastic or non-neoplastic. Hence histopathological examination is essential for both ENT surgeons as well as pathologists. Aim to study the incidence of different nasal lesion. Also, to find out frequency of inflammatory, benign and malignant conditions of nasal lesions and to compare various histopathological lesions of nasal mass in relation to age, sex and site distribution.Methods: The present study was undertaken in histopathology laboratory of Department of Pathology, P.D.U. medical college and hospital, Rajkot for period of 2 years from October 2013 to September 2015. A histopathological study of total 100 cases of nasal lesions was done. Tissue were processed and studied.Results: Out of 100 cases, 59 were males and 41 were females. Male to Female ratio was 1.44:1. Maximum numbers of nasal lesions were detected in age group of 11-20 years with 24 (24.00%) cases. Out of these 100 cases, 80 (80.00%) were non neoplastic and 20 (20.00%) were of neoplastic origin. In neoplastic lesions, 12(12.00%) were benign, 1 (1.00%) was borderline and 7 (7.00%) were malignant nasal lesions. Non neoplastic lesions were composed of the majority of cases followed by benign neoplastic lesions.Conclusions: Most of malignant neoplastic lesions were occurs after 40 years of age. Incidence of malignant neoplastic lesions was increase with advanced age.
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Švara, Tanja, Mitja Gombač, Alessandro Poli, Jožko Račnik, and Marko Zadravec. "Spontaneous Tumors and Non-Neoplastic Proliferative Lesions in Pet Degus (Octodon degus)." Veterinary Sciences 7, no. 1 (March 13, 2020): 32. http://dx.doi.org/10.3390/vetsci7010032.
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In recent years, degus (Octodon degus), rodents native to South America, have been becoming increasingly popular as pet animals. Data about neoplastic diseases in this species are still sparse and mainly limited to single-case reports. The aim of this study was to present neoplastic and non-neoplastic proliferative changes in 16/100 pet degus examined at the Veterinary Faculty University of Ljubljana from 2010 to 2015 and to describe the clinic-pathological features of these lesions. Twenty different lesions of the integumentary, musculoskeletal, genitourinary and gastrointestinal systems were diagnosed: amongst these were 13 malignant tumors, six benign tumors, and one non-neoplastic lesion. Cutaneous fibrosarcoma was the most common tumor (7/16 degus). It was detected more often in females (6/7 degus) and lesions were located mainly in hind limbs. The gastrointestinal tract was frequently affected, namely with two malignant neoplasms - an intestinal lymphoma and a mesenteric mesothelioma, four benign tumors – two biliary cystadenomas, an oral squamous papilloma and a hepatocellular adenoma, and a single non-neoplastic proliferative lesion. In one animal, two organic systems were involved in neoplastic lesions.
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Guleria, Trilok C., Shobha Mohindroo, Narender K. Mohindroo, and Ramesh K. Azad. "Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India." An International Journal Clinical Rhinology 10, no. 2 (June 24, 2017): 93–98. http://dx.doi.org/10.5005/jp-journals-10013-1316.
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ABSTRACT Introduction: Nasal masses are common finding in the ear, nose, and throat outpatient department. Most patients present with complaints of nasal obstruction. A sinonasal mass can have various differential diagnoses. They may be congenital, inflammatory, neoplastic (benign or malignant), or traumatic in nature. A careful histopathological examination is necessary to decide the nature of any particular lesion. Materials and methods: The retrospective study was carried out between January 2011 and December 2013. A total of 185 cases diagnosed with masses of the nasal cavity, paranasal sinuses, and nasopharynx were included. Data from histopathological records were retrieved to confirm the diagnosis. Observations: Among 185 cases, 75% were non-neoplastic and 25% were neoplastic. Among neoplastic masses, 57% were benign and 43% were malignant. The age of presentation ranged from first to eighth decade of life (mean age 37.74 years). The lesions had a stronger predilection for males (1.68:1). Among non-neoplastic lesions, nasal polyp was the commonest lesion followed by ethmoidal mucocele (1.44%) and lupus vulgaris (0.72%). Among benign lesions, inverted papilloma (30.77%) and nasopharyngeal angiofibroma (30.77%) were the commonest followed by capillary hemangioma (15.38%), osteoma (7.68%), nasopharyngeal lymphoepithelioma (3.85%), chondroma (3.85%), pleomorphic adenoma (3.85%), and schwannoma (3.85%). Squamous cell carcinoma (40%) was the commonest malignant neoplastic lesion observed followed by adenoid cystic carcinoma (20%), malignant melanoma (15%), nasopharyngeal carcinoma (10%), esthesioneuroblastoma (10%), and non-Hodgkin lymphoma (5%). Conclusion: Among the noninflammatory lesion, nasal polyp is the commonest lesion. Nasal polyps are more common in hilly area may be due to exposure to pine pollens. There is no difference in the histopathological profile of benign and malignant lesions. How to cite this article: Guleria TC, Mohindroo S, Mohindroo NK, Azad RK, Kumar A. Histopathological Profile of Nasal Cavity, Paranasal Sinuses, and Nasopharyngeal Masses in Hill State of Himachal Pradesh, India. Clin Rhinol An Int J 2017;10(2):93-98.
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Asimakopoulos, P., I. Hathorn, H. Monaghan, and A. T. Williams. "Incidence of neoplasia in patients with clinically suspicious nasal lesions and the value of computed tomography imaging in diagnosis." Journal of Laryngology & Otology 129, no. 3 (February 16, 2015): 254–60. http://dx.doi.org/10.1017/s0022215115000213.
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AbstractBackground:There is no consensus as to whether all routine bilateral polypectomy specimens should be sent for formal histopathological diagnosis to exclude underlying neoplastic pathology. This study assessed the necessity for histopathological investigation as routine practice in cases of bilateral and unilateral nasal lesions by estimating the incidence of unexpected pathologies. It also evaluated the ability of computed tomography to predict histopathological diagnosis in patients with unilateral nasal lesions.Methods:A retrospective analysis was conducted of 98 patients undergoing nasal polypectomy over a 12-month period.Results:Five of 23 patients with a unilateral lesion on nasendoscopy had inverted papillomas on histopathological examination. None of the 75 patients with clinically bilateral lesions on nasendoscopy showed evidence of neoplasia on histopathological examination. Patients with inverted papillomas had significantly lower total Lund–Mackay scores than those with bilateral polyps. Asymmetry scores of inverted papilloma patients were significantly higher compared to both bilateral and unilateral polyps patients.Conclusion:The results suggest that histopathological diagnosis is only necessary in unilateral lesion patients as no unexpected histopathological diagnoses were made in bilateral lesion patients. Computed tomography imaging may have a role in predicting histopathological diagnosis by demonstrating asymmetry and less overall sinus opacification in patients with neoplastic lesions.
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Ghosh, Sinjan, Gautam Guha, Kaushik Roy, Annesh Bhattacharjee, Nikhil Repaka, Sourav Nanda, and Niraja Agasti. "A rare case of tuberculoma masquerading as CP Angle neoplasm." Asian Journal of Medical Sciences 10, no. 4 (June 20, 2019): 73–75. http://dx.doi.org/10.3126/ajms.v10i4.24169.
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Tuberculoma involving the cerebellopontine angle is very rare. Preoperative neuroradiological features of such lesions may mimic neoplastic lesions. Our case presented with cerebellar features and multiple cranial nerve palsy. Neuroimaging mimicked CP angle neoplastic lesion. Antitubercular therapy and steroids resulted in significant clinical improvement and marked radiological reduction in size of the lesion. In our subcontinent a treatable infective cause like tuberculosis should be ruled out in CP angle lesions. Although rare but definitely a possibility to be considered.
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Ranabhat, S., M. Tiwari, S. Maharjan, A. Bhandari, M. Subedi, and B. P. Osti. "Histopathologic spectrum of cystic ovarian masses." Journal of Chitwan Medical College 6, no. 1 (February 16, 2017): 16. http://dx.doi.org/10.3126/jcmc.v1i1.16574.
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<p><span>This research was a cross sectional analytic observational histopathological study of cystic ovarian lesions carried out over three years from March, 2012 to February, 2015 at Chitwan Medical College Teaching Hospital in Nepal. The objective of this study was to study cystic ovarian masses histopathologically. A total of one hundred and fourteen patients with cystic ovarian masses were included into the study. 46.5% lesions were non-neoplastic (83% physiologic and 17% pathologic) and 53.5% lesions were neoplastic (91.8% benign and 8.2% malignant). Follicular cyst was the most common ovarian cystic lesion overall, followed by mature cystic teratoma and serous cystadenoma. 14.9% of all the ovarian cysts had undergone torsion; among them mature cystic teratoma was the most common lesion to have undergone the complication. Neoplastic ovarian cysts were more common than non-neoplastic. Follicular cyst was the most common ovarian cyst overall. Mature cystic teratoma was the ovarian cystic lesion to be affected by torsion most commonly.</span></p>
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Berden, Maria Emilia Servin, Ana Liesel Guggiari Niederberger, Tatiana Prosini da Fonte, Carolina Ortigosa Cunha, and Paulo César Rodrigues Conti. "Idiopathic Osteoesclerosis: A rare CBCT incidental finding in the mandibular condyle." Research, Society and Development 12, no. 3 (February 22, 2023): e5812340408. http://dx.doi.org/10.33448/rsd-v12i3.40408.
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Intrabony radiopaque lesions are common manifestations of neoplasia, sequel of carious lesions, traumatic event, malignant tumors, metastasis, neoplastic and non-neoplastic entities or developmental alterations. Idiopathic Osteosclerosis (IO) is a rare bone lesion, normally asymptomatic and not associated with inflammatory, traumatic or infectious stimulus which is usually found in the molar mandibular area. Although IO is a well-recognized radiological entity that is generally symptom-free, it is important to distinguish it from other radiopacities. Finding this type of lesion in the mandibular condyle is odd and it could be easily misdiagnosed and confused with other imaging findings. The present case report aims to describe a rare imaging finding of idiopathic osteosclerosis in temporomandibular condyle which was accidentally found in the CBCT of a patient with painful TMD symptoms by emphasizing the importance of multidisciplinary involvement between the general practitioner, the radiologist and the pain specialist to diagnose and provide an indicated treatment, whenever necessary.
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Khan, Samrin Fatima Siraj, Yasmin Altaf Momin, Alka Vikas Gosavi, and Aasawari Arun Waje. "Histopathological study of lesions of appendix." IP Journal of Diagnostic Pathology and Oncology 7, no. 4 (January 15, 2023): 233–39. http://dx.doi.org/10.18231/j.jdpo.2022.055.
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The human appendix is a supposedly funtionless organ, but can cause morbidity and mortality because it is likely to be infected. Acute Appendicitis being the most common surgical emergency. Appendicectomy specimens from suspected acute appendicitis often appear macroscopically normal but histological analysis reveal a more sinister underlying pathology.A three year study was performed to determine the incidence of various non-neoplastic and neoplastic lesions of appendix. To study the histopathology of various lesions of appendix.It is a retrospective study for a period of three years at Tertiary care hospital. The histopathological reports and clinical details were collected and slides were reviewed and evaluated. Special stains were used wherever required.The study included 1092 cases of lesions of appendix. The commonest lesion was chronic non-specific appendicitis (48.27%) followed by acute appendicitis with (47.80%). Other non neoplastic lesions found were fibrous obliteration of appendix (2.10%), chronic appendicitis with Enterobius vermicularis infestation (0.83), tuberculosis (0.18), xanthogranulomatous appendicitis (0.09%) and amoebic appendicitis (0.09%). Neoplastic lesions seen were low grade mucinous neoplasm (0.18) and serrated adenoma (0.09). Chronic non-specific appendicitis is the commonest appendiceal lesion. The various lesions of appendix clinically present as acute or chronic appendicitis but histology reveals the true nature of the lesion and hence remains the gold standard method.
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Baidya, R., B. Sigdel, and NL Baidya. "Histopathological pattern of testicular lesion." Journal of Pathology of Nepal 7, no. 1 (March 30, 2017): 1087–90. http://dx.doi.org/10.3126/jpn.v7i1.16945.
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Background: Testicular tumors are rare type of tumors affecting adolescents and young adults. The testicular tumors constitute 4th most common cause of death from neoplasm in a younger male.The present study is undertaken to analyze the pattern and age wise distribution of testicular lesions in our hospital.Materials and methods: This was a prospective study done over a period of 4 years from November 2012 to October 2016, after taking approval of the ethics committee and informed consent from the patients. Histopathological slides were retrieved and reviewed for tumor and its subtype.Results: A total of 60 cases of testicular lesions were encountered in our study. Out of the total 60 cases,15% (9/60) were diagnosed as malignant testicular tumor.Most of these tumors were seen between 3rd and 4th decades.Germ cell tumor was the most common type (77.7%) among which seminomas (44.44%) and mixed germ cell tumors(28.57%) were most frequently encountered.Other tumor diagnosed was Non-Hodgkin lymphoma. Non-neoplastic lesions of the testis are most common in the second decade of life. The youngest patient was at birth and oldest was 71 years of age. Out of all non-neoplastic lesions, vascular lesions like torsion and infarction are the most common findings (54.90%) followed by tuberculous abscess (15.68%).Conclusion: Testicular tumors are uncommon in our population. Histopathological spectrum of our study was comparable with other parts of the world,germ cell tumor accounted for highest percentage of cases in neoplastic lesions and torsion and infarction are the common findings in non-neoplastiic lesions of testis.
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M., Sheela K., and Sreedevi A. R. "Histopathological analysis of thyroid lesions: an institutional experience." International Journal of Advances in Medicine 5, no. 5 (September 22, 2018): 1217. http://dx.doi.org/10.18203/2349-3933.ijam20183897.
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Background: Diseases of thyroid are one of the most common endocrine disorders affecting general population which range from non-neoplastic to neoplastic lesions. The incidence and pattern of thyroid lesions depend on various factors which include sex, age, ethnic and geographical patterns. Majority of thyroid lesions are non-neoplastic only <5% are malignant. The aim of the present study was to determine the frequency and histomorphological pattern of thyroidectomy specimens and their relationship with age and sex of the patient.Methods: This retrospective study was conducted in the department of pathology, Govt. Medical College, Alappuzha for a period of 2 years. The study included 620 thyroidectomy specimens received in the Department of Pathology. All the biopsy reports were reviewed, and different lesions were categorised according to age and gender distribution. The data was analysed by standard statistical methods.Results: The commonest of the non-neoplastic lesions was nodular colloid goiter followed by lymphocytic thyroiditis, Hashimoto thyroiditis Nodular hyperplasia and thyroglossal cyst. Most common malignant lesion in this study is papillary carcinoma and benign lesion is follicular adenoma. Age group of patients ranged from 6 ½ to 84 years. The study showed a female predominance of 88.38%.Conclusions: Thyroid disorders are commonly encountered endocrine diseases. The study showed a female predominance. Peak age of incidence of thyroid lesions was between 40 and 50 years. Most common lesion was follicular adenoma and most common malignant lesion was papillary carcinoma.Histopathological examination is the mainstay for definite diagnosis and management of thyroid neoplasms.
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Moinfar, Farid. "Flat Ductal Intraepithelial Neoplasia of the Breast: A Review of Diagnostic Criteria, Differential Diagnoses, Molecular-Genetic Findings, and Clinical Relevance—It Is Time to Appreciate the Azzopardi Concept!" Archives of Pathology & Laboratory Medicine 133, no. 6 (June 1, 2009): 879–92. http://dx.doi.org/10.5858/133.6.879.
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Abstract Context.—More than 25 years ago, John G. Azzopardi described a distinctive intraepithelial neoplastic breast lesion, which he designated “clinging carcinoma in situ”; he considered it as another variant of ductal carcinoma in situ, an early lesion that can easily be missed because the changes are mainly cytologic rather than architectural. The lesion remained widely unrecognized and/or ignored until recent years when its neoplastic nature was confirmed at the molecular-genetic level. Objective.—To deal with historical aspects of the evolving concept of “clinging” and to focus on several important issues such as characteristic morphologic features with particular attention to the diagnostic criteria and differential diagnoses, recent molecular-genetic findings, appropriate terminology and classification, as well as the significance of this type of lesion for both surgical pathologists and clinicians. Data Sources.—A thorough search of the literature was performed and publications using a variety of designations including “clinging carcinoma in situ,” “flat epithelial atypia,” “ductal intraepithelial neoplasia-flat type,” “atypical cystic lobules,” “columnar cell change with atypia,” “columnar cell hyperplasia with or without atypia,” “columnar alteration with prominent apical snouts and secretion,” and so forth were reviewed. Conclusions.—This distinctive lesion represents one of the earliest morphologically recognizable neoplastic alterations of the breast that is commonly associated with mammographically suspicious microcalcifications. It is characterized by mildly to severely atypical cells simply replacing the single layer of native epithelial cells in a flat fashion without appreciable proliferation; tufting, intraluminal bridging, micropapillary structures, and so forth are typically absent or very focal and minimal, if present at all. Based on the degree of cytologic atypia, low- and high-grade flat ductal intraepithelial neoplasia need to be separated. Although additional studies are needed to better understand the clinical significance of flat ductal intraepithelial neoplasia, several lines of evidence strongly support the concept of clinging. Indeed, as pointed out by Azzopardi, surgical pathologists need to pay more attention to the cytologic alterations of the breast lesions by analyzing the involved cell populations using high-power magnification.
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Kaur, Dupinder, and Pooja Agarwal. "To study the relationship of parity and laterality with different ovarian lesions." IP Journal of Diagnostic Pathology and Oncology 6, no. 2 (June 15, 2021): 135–37. http://dx.doi.org/10.18231/j.jdpo.2021.029.
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The present study is based on histomorphological evaluation in 107 cases of Ovarian neoplastic and non-neoplastic lesions received. The gross specimens received were fixed in 10 percent formalin for 24 hours. Gross examination was done carefully examining the outer surface and on-cut surface of ovary, looking for any cyst with its content and type of fluid filled inside, any solid area, papillary projections and growth. Observational study.Among 69 non neoplastic lesions, right sided cases found in 34 (49.4%), and left sided lesion found in 22 cases (31.8%). 13 cases (18.8%) of non neoplastic lesions are observed to be bilateral. Like non neoplastic lesions, neoplastic lesions are also found more common on right side (55%) than left (35%), while bilaterality is found in 10% of the cases. The results of present study are comparable to other series of studies regarding occurrence with respect to age, bilaterality, gross features and microscopy. Both non neoplastic and neoplastic lesions were more common in right side. 18% of non neoplastic and 11% of neoplastic lesions were found to be bilateral.
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Jha, Krishna Kumar, and Mrinalini Singh. "Histopathological study of non neoplastic lesion in cervix at Birat Medical College Teaching Hospital Nepal." Journal of Chitwan Medical College 8, no. 4 (December 31, 2018): 34–37. http://dx.doi.org/10.3126/jcmc.v8i4.23766.
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Introduction: Like in other developing countries non –neoplastic region of cervix in pap smear is most common findings. In Nepal... In Nepal cervical pap-smear screening is not done my most of woman due to lack of awareness. The objective of this study is to find the prevalence of non-neoplastic lesion of cervix.
Methods: This was a retrospective study of 486 conventional cervical Pap smears reported from the Department of Pathology. The time period was from March 2015 to May 2018. We used Bethesda system to report our all our slides. All the cases were reviewed by consultant pathologist of Birat medical college. This research is done according to rule of BMCTH.
Results: Total cases were 486 in two years period in which 456 cases were satisfactory for evaluation and 30 cases were unsatisfactory for evaluation which is due to thick neutrophilic exudates, mucous, degenerative cells and hemorrhage. The age of the patients ranged from 20 to 80 years with an average age of 35.5 years. Non specific inflammatory smear is 440 that is 90.53%, Bacterial vaginosis is 10 that is 2.05%, Candidiasis is 04 that is 0.82% and trichomonas vagenalis is 02 that is 0.41%.
Conclusion: Simple screening test like cervical papanicolaou smear (Pap)can detect the non-neoplastic lesion of cervix. If non-neoplatic lesion of cervix is not treated as soon as possible than the chances of being infertility, salpingitis and even neoplasia is more. So non-neoplastic lesion of cervix is as important as neoplastic lesion of cervix.
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Pech, Oliver, and Saleh A. Alqahtani. "Update on endoscopic treatment of Barrett’s oesophagus and Barrett’s oesophagus–related neoplasia." Therapeutic Advances in Gastrointestinal Endoscopy 13 (January 2020): 263177452093524. http://dx.doi.org/10.1177/2631774520935241.
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Endoscopic therapy of early Barrett’s oesophagus–related neoplasia is the treatment of choice for low-grade-dysplasia, high-grade dysplasia and mucosal Barrett’s cancer. Low-grade-dysplasia without any visible lesion should be ablated, preferably with radiofrequency ablation. In cases with the presence of a visible lesion, high-grade dysplasia and early Barrett’s adenocarcinoma, endoscopic resection techniques like multiband ligation endoscopic resection or endoscopic submucosal dissection should be applied. After complete resection of all visible neoplastic lesions, ablation of the remaining Barrett’s oesophagus should be performed to prevent recurrence. Ablation techniques available are radiofrequency ablation, argon plasma coagulation and cryoablation.
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Belghazi, Kamar, Jacques Bergman, and Roos E. Pouw. "Endoscopic Resection and Radiofrequency Ablation for Early Esophageal Neoplasia." Digestive Diseases 34, no. 5 (2016): 469–75. http://dx.doi.org/10.1159/000445221.
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Background: In the last few decades, endoscopic treatment of early neoplastic lesions in the esophagus has established itself as a valid and less invasive alternative to surgical resection. Endoscopic resection (ER) is the cornerstone of endoscopic therapy. Next to the curative potential of ER, by removing neoplastic lesions, ER may also serve as a diagnostic tool. The relatively large tissue specimens obtained with ER enable accurate histological staging of a lesion, allowing for optimal decision-making for further patient management. ER was pioneered in Japan, mainly for the resection of gastric lesions and squamous esophageal neoplasia, and also Western countries have been increasingly implementing ER in the treatment of early gastroesophageal neoplasia, mostly associated with Barrett's esophagus (BE). In BE, however, there is still a risk of metachronous lesions in the remainder of the Barrett's after focal ER. Additional treatment of all Barrett's mucosa is therefore advised. Currently, the most effective method for this is by using radiofrequency ablation (RFA). This review will provide an overview of indications for ER and RFA. Key Messages and Conclusions: Endoscopic management of early esophageal neoplasia is a safe and valid alternative to surgery and is nowadays the treatment of choice. ER is the mainstay of endoscopic management of early esophageal neoplasia since it allows for removal of neoplastic lesions and provides a large tissue specimen for histological evaluation. In case of early neoplasia in BE, focal ER should be complemented by eradication of the remaining Barrett's mucosa. RFA has proven to be a safe and effective modality to achieve complete eradication of Barrett's mucosa.
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Odze, Robert D., and Carlo C. Maley. "Neoplasia Without Dysplasia: Lessons From Barrett Esophagus and Other Tubal Gut Neoplasms." Archives of Pathology & Laboratory Medicine 134, no. 6 (June 1, 2010): 896–906. http://dx.doi.org/10.5858/134.6.896.
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Abstract Context.—Classic pathology teaching emphasizes that neoplastic lesions of the gastrointestinal tract are characterized by architectural and cytologic abnormalities that distinguish it from normal tissue. Recent studies suggest that many important—and in some cases clonal—molecular abnormalities that lead to dysregulation of cell proliferation and differentiation (neoplasia) occur before morphologic expression of dysplasia. Objective.—To summarize the biologic and pathologic features of preneoplastic conditions of the tubal gut that reveal evidence of neoplastic alteration, but without the traditional morphologic features of dysplasia, in order to provide guidance on how to identify these lesions. Particular attention is given to Barrett esophagus, a chronic inflammatory condition in which early molecular and morphologic events that drive carcinogenesis are best understood. Data Sources.—Selected references and abstracts were obtained by a PubMed (US National Library of Medicine) search by using the search headings neoplasia, preneoplasia, dysplasia, adenoma, serrated polyps, and Barrett's esophagus between the years 1980 and 2009. Conclusions.—Many types of lesions throughout the tubal gut fulfill the most basic and classic principles of a neoplastic precursor lesion but lack conventional morphologic evidence of dysplasia and/or maintain the capacity for cell differentiation and maturation. All of these lesions, such as squamous dysplasia of the esophagus, dysplasia in Barrett esopahagus, and hyperplastic/serrated polyps of the colon, represent early neoplastic precursor lesions but without conventional histologic features of dysplasia. It is important for pathologists to be aware of these lesions, both for diagnostic and prognostic purposes, but also so that future studies can be performed with regard to risk stratification of patients.
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Sathe, Pragati, and Ankita Asthana. "Paediatric Eyelid Lesions- A Report of 20 Cases." Annals of Pathology and Laboratory Medicine 7, no. 10 (October 29, 2020): A509–513. http://dx.doi.org/10.21276/apalm.2846.
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Background: Eyelid lesions are one of the commonest lesions encountered by ophthalmologists in their clinical practice. They could be classified in various ways such as neoplastic or non-neoplastic; congenital or acquired. The common benign conditions affecting the eyelid include cysts like dermoid, epidermoid and epithelial cysts, inflammatory lesions, melanocytic nevi and papilloma. Ignorance about the benign nature of the lesion may lead to increased debility.
The purpose of this study is to contribute information to the literature on various eyelid lesions and their incidence as found in a tertiary hospital.
Methods: This is a retrospective observational study of surgically excised eyelid lesions in patients below 12 years of age. The study was conducted after obtaining permission from the Institutional Ethics Committee.
Result: Out of 20 lesions, 15 cases belonged to the non-neoplastic category while five cases were neoplastic in nature. Cystic lesions predominated in the non-neoplastic category (11 out of 15 cases). The remaining four cases in the non-neoplastic category included three cases of infective etiology and one case of developmental etiology. There were no malignant neoplasms found in our study. The common presenting feature was that of eyelid swelling. Highest incidence of eyelid lesions was in the upper lid (14 of 20 cases, i.e. 66.66%).
Conclusion:
It is necessary to subject every lesion of the eyelid to histopathological examination. Sometimes, clinically benign lesions turn out to be malignancies which entails a wider surgery later. This study points out to the wide spectrum of lesions that can afflict the eyelid.
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Tarkan, Ö., F. Çetİk, and S. Uzun. "Auricular cutaneous leishmaniasis mimicking neoplastic disease." Journal of Laryngology & Otology 126, no. 8 (June 15, 2012): 821–24. http://dx.doi.org/10.1017/s0022215112001120.
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AbstractObjective:Leishmaniasis comprises a group of diseases transmitted by the bite of infected sand flies. There are three basic clinical forms of leishmaniasis: cutaneous, mucocutaneous and visceral. Leishmaniasis may mimic neoplastic lesions and other infectious diseases because of similar disease localisation, physical characteristics and histopathological findings.Case report:A 35-year-old man was referred to our clinic with a presumed diagnosis of angiolymphoid hyperplasia of the auricle; however, this lesion proved to be cutaneous leishmaniasis. The definitive diagnosis was reached by identifying the parasites on smears obtained from the lesion.Conclusion:It should be borne in mind that cutaneous leishmaniasis presenting as isolated auricular lesions may mimic neoplasia. In the present case report, we discuss auricular cutaneous leishmaniasis and we review the relevant literature.
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Shah, Anita, Manglesh Srivastava, Ashok Samdurkar, and Ghanshyam Sigdel. "Spectrum of Lesions in Urinary Bladder- A Histopathological Study." Journal of Universal College of Medical Sciences 6, no. 2 (December 3, 2018): 24–27. http://dx.doi.org/10.3126/jucms.v6i2.22473.
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Introduction: The lesions of urinary bladder both non-neoplastic and neoplastic pose a common source of both morbidity and mortality. An accurate diagnosis of these lesions requires cystoscopy which allows a direct visualization of the bladder mucosa and biopsies of suspected lesions. Urinary bladder cancer is sixth most common cancer worldwide and represents a heterogeneous group of neoplasms. The current study aimed to study the different bladder lesions and its clinical features to detect it in early stage and as a mainstay option in the diagnosis and follow up.
Materials and methods: This was a retrospective analysis of biopsies of urinary bladder submitted to the department of pathology over a period of 12 months. The study was approved by the institutional review board of the Universal College of Medical Sciences (UCMS-TH). All the urinary bladder biopsies received in the department were included in the study whereas autolysis of specimen and inadequate biopsies were excluded.
Results: Among the 36 cases of urinary bladder lesions, the majority (35.36%) were in age group 61-70 years (22.33%). The patients had combination of lower urinary tract symptoms, the commonest being hematuria. 30.55% had non-neoplastic lesions and 69.55% had neoplastic lesion. Among non- neoplastic cases, 5.55% had chronic granulomatous inflammation. Most common neoplastic lesions was infiltrating urothelial carcinoma (n=6) followed by non- invasive urothelial neoplasia (n=5).
Conclusion: A variety of lesions occur in urinary bladder and is commonly encountered by pathologist. Hematuria was commonest symptom and the clinicians investigated these patients further, which led to discovery of the urothelial tumors. Identification of these patients has an important impact on prognosis as well as on therapeutic approach.
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Cruz, Gabriela Medeiros da, Samuel Trezena, Sabina Pena Borges Pêgo, Lívia Máris Ribeiro Paranaíba, Daniella Reis Barbosa Martelli, and Mario Rodrigues de Melo Filho. "Profile evaluation of patients diagnosed with non-neoplastic proliferative lesions in a dentistry clinic." Brazilian Journal of Oral Sciences 18 (April 8, 2019): e191350. http://dx.doi.org/10.20396/bjos.v18i0.8655140.
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Non-neoplastic proliferative lesions (NNPLs) are alterations that affect oral mucosal tissues. The etiology of these lesions is associated with local irritant processes, principally inflammation, infections and mechanical irritants. NNPLs are classified into four groups: inflammatory fibrous hyperplasia, pyogenic granuloma, peripheral ossifying fibroma, and peripheral giant cell lesion. Aim: This cross-sectional, quantitative, retrospective, analytical, informative and educational study aimed to evaluate the profiles of patients who were diagnosed with any non-neoplastic proliferative lesion in the Unimontes Stomatology Clinic, Brazil. Methods: From January 2001 to June 2012, 1505 patients were counted who underwent anatomopathological examination, in addition to evaluations for other conditions. Results: Of these 1505 patients, 223 were diagnosed with some type of non-neoplastic proliferative lesion, and statistical analysis showed that 76% were female and 24% male and that 23.3% were between 41 and 50 years of age. Inflammatory fibrous hyperplasia was the most common NNPL (86.5%). Conclusion: Due to the high frequency of these lesions in the dental clinic, this type of survey has significant relevance for informing health professionals about these proliferative processes. This information is necessary, since the dentist is intimately involved in both the etiology, treatment and prevention of these lesions.
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Laishram, Rajesh Singh, Arun Kumar K., Gayatri Devi Pukhrambam, Sharmila Laishram, and Kaushik Debnath. "Pattern of salivary gland tumors in Manipur, India: A 10 year study." South Asian Journal of Cancer 02, no. 04 (October 2013): 250–53. http://dx.doi.org/10.4103/2278-330x.119886.
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Abstract Background: Salivary gland lesions, especially the neoplastic lesions constitute a highly heterogeneous histopathologic group. Several studies have reported a significant difference in the global distribution of salivary gland tumors, but no formal study has been carried out in this part of the globe. Objectives: To document the pattern of various salivary gland tumors in Manipur, a state in North Eastern India. Materials and Methods: This is a 10 years (2002-2011) retrospective study of all salivary gland specimens received at our referral teaching hospital in Manipur, India. All the histopathology slides of salivary gland specimens during the study period were reviewed and clinical details were obtained from the archives. Restaining of slides and fresh sections of tissue blocks were performed whenever required. Data thus collected were analyzed. Results: A total of 104 cases of salivary gland lesions were studied during the study period. Age ranged from 5 years to 78 years with an overall slight female preponderance (M:F = 1:1.08). Parotid (56.65%) was the commonest gland involved followed by submandibular gland (31.73%). Neoplastic lesions comprised of 78 (75%) cases and non-neoplastic lesions constituted 25% (26 cases). Among the neoplastic lesions, benign lesions (53.85%) predominated over malignant lesions (21.15%). Pleomorphic adenoma was the commonest benign neoplastic lesion and mucoepidermoid carcinoma was the commonest malignant tumor. Chronic sialadenitis was the predominant lesion in the non-neoplastic group. Conclusion: The principal site for salivary gland tumors was the parotid gland and pleomorphic adenoma outnumbered all the other tumors. Females are more affected in the malignant group.
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Amit, Maniyar U., Harshid Laxmanbhai Patel, and BH Parmar. "Study of Cytodiagnosis of Head and Neck Neoplastic Lesions and Comparison with Histopathology." International Journal of Head and Neck Surgery 4, no. 3 (2013): 119–22. http://dx.doi.org/10.5005/jp-journals-10001-1157.
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ABSTRACT Introduction The development of aspiration cytology is one of the biggest advances in anatomic pathology. Cancer has become one of the 10 leading causes of death in India. Head and neck neoplasia is a major form of cancer in India, accounting for 23% of all cancers in males and 6% in females. The advantages of fine needle aspiration cytology (FNAC) are: it is safe, sensitive and specific for the diagnosis of malignancy, gives a rapid report, requires little equipment, causes minimal discomfort to the patient, is an out patient procedure, repeatable and cost effective avoids the use of frozen section, reduces the rate of exploratory procedures and allows a definitive diagnosis of inoperable cases. FNAC is of particular relevance in head and neck lesions because of easy assessibility, excellent patient compliance, minimally invasive nature of procedure and helping to avoid surgery in non-neoplastic lesions, inflammatory conditions and also some tumors. Aims and objectives To test the utility of FNAC, to establish the diagnostic accuracy of cytology by comparison with histopathology diagnosis and to establish the sensitivity and specificity of this technique in head and neck neoplastic lesion. Materials and methods The present study was undertaken in the Department of Pathology, Government Medical College and Hospital, Nashik, between January 2008 and June 2009. Results In the present study, maximum number of aspirates from head and neck neoplastic lesions were found to be of lymph nodes (56.37%). Of the total 378 cases, 71.69% were malignant. 6th decade was the most common age group affected (26.46%). Mean age group was found to be 45.84 years. Males were more commonly affected (65.34%). The male to female ratio was 1.8:1. Out of 92 cases available for follow-up, 85.87% of the cases were same as histopathological diagnosis. Summary and conclusion Excisional biopsy remains the gold standard for diagnosis of head and neck neoplastic lesion, cytological study can establish the diagnosis of the majority of head and neck neoplastic lesions and can be recommended as an adjunct to histopathology. How to cite this article Amit MU, Patel HL, Parmar BH. Study of Cytodiagnosis of Head and Neck Neoplastic Lesions and Comparison with Histopathology. Int J Head Neck Surg 2013; 4(3):119-122.
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Sahu, Preeti Rajendra, Kishor Madhukar Hiwale, and Sunita Jayant Vagha. "Study of Various Gastrointestinal Tract Lesions by Endoscopic Biopsies in a Tertiary Care Centre of Rural District of Maharashtra." Journal of Evolution of Medical and Dental Sciences 10, no. 16 (April 19, 2021): 1135–39. http://dx.doi.org/10.14260/jemds/2021/242.
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BACKGROUND In a developing country like India, vast difference exists in people’s religion, culture, and socio-economic condition and along with it, there exists a significant difference in their dietary habits. This has led to an incidence of a large spectrum of gastrointestinal (GI) diseases which is different in different geographical locations. The study was undertaken for studying the spectrum of various histopathological lesions of gastrointestinal tract with the help of endoscopic biopsy. METHODS This cross-sectional study was carried out in a span of 2 years in the histopathology division. The study included 105 patients who had GI complains and underwent endoscopic biopsies for the same. RESULTS The present study included a total of 105 cases out of which there were 64 cases (61 %) of upper GI tract biopsies and remaining 41 cases (39 %) were of lower GI tract biopsies. Among 64 (100 %) cases of upper GI biopsies, reflux oesophagitis (4.67 %) was the most common in non-neoplastic lesions while well differentiated squamous cell carcinoma (20.31 %) was the most common neoplastic pathology. In gastric biopsies, chronic atrophic gastritis (3.12 %) was the most common condition in a non-neoplastic category, while gastric adenocarcinoma (15.61 %) was the malignant lesion which was found. Among duodenal biopsies, the most common lesion was eosinophilic enteritis / duodenitis (14.06 %). Among 41 (100 %) colonoscopic biopsies, the most common lesion was chronic non-specific inflammation (12.19 %) under non-neoplastic category, while well differentiated adenocarcinoma (46.34 %) was most common entity under malignant category in our study. Non-neoplastic lesions were more common in upper GI endoscopic biopsies whereas, neoplastic lesions were more frequently seen with lower GI endoscopic biopsies. CONCLUSIONS Performing endoscopy alone is an incomplete investigative modality for the diagnosis. While performing endoscopy and simultaneously taking biopsy for histopathological evaluation helps in giving an accurate diagnosis. KEY WORDS GIT, Endoscopy, Endoscopic Biopsy
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Nishal, Arpita, Himani Bajaj, Rasik Hathila, Mubin Patel, Pinal Shah, Archana Patel, and Rishikesh Balvalli. "Histomorphological Study of Non Neoplastic Skin Lesions: A Retrospective Approach." International Journal of Current Research and Review 14, no. 13 (2022): 77–85. http://dx.doi.org/10.31782/ijcrr.2022.141313.
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Introduction: Non-neoplastic skin disorders encompass a wide spectrum of pathological processes which show age, sex and geographical variation in distribution. Histopathological examination continues to play an invaluable role in diagnosis and management of non neoplastic skin disorders. The present study aims to analyse the histomorphological spectrum of non-neoplastic skin lesions received in a tertiary care hospital, to study their age and sex distribution and to classify the lesions into categories that predict clinically important attributes. Material and Methods: The current study is an observational retrospective study conducted in Department of Pathology in a Tertiary Care Hospital in South Gujrat. 205 skin specimen of non neoplastic skin lesions received over a period of one year (February 2019 to January 2020) were studied. Results: Among 205 cases of non neoplastic skin lesions, male predominance was seen. 21-30 years and 31-40 years were the most common age group. Infectious disorders were the most common category (73 cases) followed by non-neoplastic cutaneous cysts (72 cases). Epidermoid cyst was the common skin lesion closely followed by Leprosy. Borderline Tuberculous was the most frequent subtype of leprosy. Leprosy was most common in 21-30 years age group. Most common vesicobullous disease was Spongiotic Dermatitis followed by Pemphigus Vulgaris. Psoriaform and lichenoid dermatitis showed equal incidence. Conclusion: Heterogeneity in the clinical presentation of skin diseases makes histopathological examination a gold standard technique for final diagnosis. Cutaneous cysts and infectious formed the bulk of cases. Leprosy was the most common non cystic non neoplastic skin lesion of our study.
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Colegrove, K. M., F. M. D. Gullanda, D. K. Naydan, and L. J. Lowenstine. "Tumor Morphology and Immunohistochemical Expression of Estrogen Receptor, Progesterone Receptor, p53, and Ki67 in Urogenital Carcinomas of California Sea Lions (Zalophus californianus)." Veterinary Pathology 46, no. 4 (March 9, 2009): 642–55. http://dx.doi.org/10.1354/vp.08-vp-0214-c-fl.
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Metastatic carcinoma of urogenital origin is a common cause of mortality in free-ranging California sea lions (Zalophus californianus). The etiology of this cancer is likely multifactorial, with viral infection, genetic factors, and exposure to environmental organochlorine contaminants possible contributing factors. In this study, expression of estrogen receptor α (ER α), progesterone receptor (PR), p53, and Ki67 were evaluated by immunohistochemistry in 12 sea lions with metastatic carcinoma, genital epithelial dysplasia, and intraepithelial neoplasia; 4 with genital epithelial dysplasia and intraepithelial neoplasia without metastases; and 6 control animals. Dysplastic and neoplastic lesions were identified in multiple areas of the cervix, vagina, penis, prepuce, and urethra in affected animals, suggesting multicentric development. Lesions were graded according to degree of epithelial dysplasia and infiltration and lesions of different grades were evaluated separately. Estrogen receptor expression was lower in intraepithelial lesions compared with normal genital epithelium, and expression in metastatic lesions was completely absent. There was progesterone receptor expression in neoplastic cells in intraepithelial lesions of all grades and in metastases, with no significant difference between lesion grades or between control and affected epithelium. Ki67 index and p53 expression increased with lesion grade and were higher in lesions than normal epithelium. Metastatic tumors exhibited highly variable morphology; however, proliferation index, ER α, PR, and p53 expression were similar in tumors with different patterns of growth. These results suggest that endogenous hormones, environmental contaminants that interact with steroid hormone receptors, and alterations in p53 may play a role in urogenital carcinogenesis in California sea lions.
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Jha, A., and AK Chaurasia. "A retrospective analysis of cervical smears for detection of precancerous lesions." Journal of Pathology of Nepal 5, no. 10 (September 14, 2015): 847–49. http://dx.doi.org/10.3126/jpn.v5i10.15641.
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Background: Diseases of the cervix are common in women. Detection of neoplastic lesions is of prime importance in the evaluation of cervical smears although their frequency is less than the non-neoplastic conditions. Reactive and inflammatory conditions, however, may mimic or obscure the dysplastic changes. The aim of this study was to evaluate the frequencies of various inflammatory, reactive and neoplastic lesions in the cervical smears.Materials and Methods: This was a retrospective study of 150 cases of cervical smears collected from medical record section of the hospital and Department of Pathology at National Medical College from April 2013 to April 2015.Results: Of 150 patients who underwent cervical cytology, only 15 cases (10%) had epithelial cell abnormalities. This was followed by reactive cellular changes associated with inflammation (16.7%), infections (5.3%) and atrophy (1.3%). Low grade squamous intraepithelial lesion (6%) was the most common epithelial cell abnormality followed by high grade squamous intraepithelial lesion (2%), atypical glandular cells (1.3%) and squamous cell carcinoma (0.7%).Conclusion: Reactive changes including atrophy were the commonest finding. Squamous intraepithelial lesion was commonest finding among epithelial abnormalities. Glandular intraepithelial lesions and squamous cell carcinoma were also identified. Among infections Trichomoniasis and candidiasis were seen.
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Zelaya, R., and C. J. Atkinson. "Pictorial Review of Calcified Pseudoneoplasm of the Neuroaxis and Other Calcified Intracranial Lesions." Neurographics 12, no. 1 (January 1, 2022): 1–16. http://dx.doi.org/10.3174/ng.2100006.
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Neuroimaging is an essential tool in characterizing calcified intracranial lesions. This article outlines a pictorial review of different calcified lesions of the neuroaxis with discussion of distinguishing radiologic features and clinical and histologic characteristics. There will be an emphasis on the uncommon histologic entity known as calcified pseudoneoplasm of the neuroaxis (CAPNON), a non-neoplastic lesion that is sometimes mistaken for the more common neoplastic and non-neoplastic lesions. It is essential for radiologists to identify key distinguishing imaging features of various calcified intracranial lesions to narrow diagnostic considerations and collaborate with management decisions.Learning Objective: To offer a review of the uncommon histologic entity called calcified pseudoneoplasm of the neuroaxis (CAPNON) and to provide a differential diagnosis and several sample cases of other calcified lesions of the neuroaxis to help the reader differentiate and distinguish CAPNON from more common neoplastic and non-neoplastic lesions
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Donaldson, K., A. A. Arif, H. Qian, E. Lam, and N. C. Shahidi. "A105 ENDOSCOPIC MUCOSAL RESECTION AND ENDOSCOPIC SUBMUCOSAL DISSECTION FOR ILEOCECAL VALVE NEOPLASIA: A SYSTEMATIC REVIEW AND META-ANALYSIS." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (February 21, 2022): 121–22. http://dx.doi.org/10.1093/jcag/gwab049.104.
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Abstract Background Neoplastic lesions at the ileocecal valve (ICV) represent a complex lesion subgroup given the unique anatomical characteristics of this location. Both endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are established techniques for colorectal neoplasia but comparative analyses for ICV lesions are lacking. Aims Evaluate the performance of EMR and ESD for ICV neoplasia. Methods Between Jan 2000 to Aug 2021, two authors independently searched MEDLINE, EMBASE and Cochrane Libraries for relevant citations evaluating the performance of either EMR and/or ESD for ICV neoplasia; defined as lesions involving at least one component of the ICV complex. The rate of technical success (complete removal of all neoplastic tissue during index procedure of those lesions deemed amenable to endoscopic resection), clinically significant post-endoscopic resection bleeding (CSPEB), delayed perforation, and recurrence were assessed. Meta-analysis was performed using a random-effects model. Results Nine studies (367 patients, 252 EMR, 115 ESD) were included in the analysis. Successful removal of all visible neoplastic tissue of those deemed amenable to endoscopic resection was 98.1% (EMR 99.6%, ESD 97.4%). Of note, only 2 studies, both assessing EMR, provided data on lesions which were not considered for endoscopic resection ranging from 5.6–23.7%. Average procedure time ranged from 45–49 minutes for EMR and 52–191 minutes for ESD. Clinically significant post-endoscopic resection bleeding occurred in 6.2% (EMR 9.4%, ESD 4.4%). Delayed perforation occurred in 0.6% (EMR 0.4%, ESD 2.0%). Recurrence occurred in 3.1% (EMR 13.2%, ESD 1.9%). Conclusions Endoscopic resection, both with EMR and ESD, demonstrates high technical success and good adverse event profiles amongst ICV neoplasia deemed amenable for endoscopic resection. Funding Agencies None
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Patel, Piyush Ashokbhai, Deval Narendrakumar Patel, Mona Manubhai Patel, and Jignasa Nathalal Bhalodia. "A Study of Histopathological Spectrum of Ovarian Neoplastic and Non-Neoplastic Lesions at Teaching Hospital, Ahmedabad." Annals of Pathology and Laboratory Medicine 7, no. 10 (October 29, 2020): A514–521. http://dx.doi.org/10.21276/apalm.2856.
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Background: Ovarian carcinoma is one of the most common gynecologic cancers that ranks third after cervical and uterine cancer. ovarian lesions are neoplastic and non neoplastic and many neoplastic lesions are asymptomatic and possess great challenge to the gynecological oncologist.
Aims & Objectives: To analyze frequency, age distribution and histopathological spectrum of ovarian lesions at teaching hospital, Ahmedabad.
Materials & Method: This study was undertaken between period of 1st January 2018 to 29th February 2020 at Department of Pathology, GMERS Medical college, sola, Ahmedabad. H and E stained slides were examined by light microscopy and histopathological type of lesions were classified according to World Health Organization (WHO) classification -2014.
Results: There were total 182 cases of ovarian lesions. 56(30.76%) cases are neoplastic, among them only 6(10.71%) were malignant. Surface epithelial tumor (n=27 cases, 48.21%) were most common neoplastic lesion while sex cord stromal tumor (n=8 cases,14.29%) were least common. Most common age group affected for neoplastic lesions was 31-40 years.
Conclusion: We found that ovarian lesions affect wide variation of age starting from 11 years young patient to 65 years old patients. Non neoplastic lesions were almost double in prevalence than neoplastic lesions. Histopathological analysis according to WHO classification reveal that surface epithelial tumors and germ cell tumors were forms the majority of neoplastic lesions.
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Chawda, Hanish Kumar, and Hemavathi Reddy. "Neoplastic lesion in surgically removed appendix." MedPulse International Journal of Pathology 12, no. 3 (2019): 176–79. http://dx.doi.org/10.26611/10512312.
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Li, L., and D. Suster. "Meningothelial Hamartoma of the Scalp: Clinicopathologic Review of an Unusual Tumor Mimicking a Vascular Neoplasm with Review of Literature." American Journal of Clinical Pathology 156, Supplement_1 (October 1, 2021): S46—S47. http://dx.doi.org/10.1093/ajcp/aqab191.094.
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Abstract Introduction/Objective Benign meningothelial hamartoma of the scalp is a rare entity with only scattered case reports existing in the literature. The hamartomatous process is believed to occur secondary to ectopic displacement during embryogenesis with the migration of meningothelial cell precursors to the incorrect location or secondary to an obliterated meningocele. This tumor may be easily missed and may be misdiagnosed as lipoma or sometimes as cutaneous angiosarcoma due to the several histologic features that mimic the histology of a vascular neoplasm. Methods/Case Report We report an unusual benign skin lesion occurring in a 19-year-old man with no significant past medical history. The lesion had been present since he was an infant and had been slowly enlarging over the past 15 years. The lesion caused pain and discomfort and the patient underwent an excisional biopsy of the lesion. Histologic examination showed a subcutaneous lesion with ill-defined borders and peripheral areas of infiltration between adnexal structures. Immunohistochemistry performed on the tumor cells showed that they were positive for EMA, progesterone receptor, D2-40, and vimentin. A next-generation sequencing study using a hybrid capture-based panel examining 50 commonly mutated genes in human neoplasia was performed and showed no molecular alterations supporting the benign or non-neoplastic nature of the lesion. Along with this case, we review 20 cases of meningothelial hamartomas from 13 papers and summarize them in the table. Results (if a Case Study enter NA) N/A Conclusion To our knowledge, this is the first reported case of one of these lesions with associated molecular genetic testing. The molecular study carried out, in this case, did not disclose any genetic variants commonly associated with human neoplasia supporting the notion that this lesion does not represent the neoplastic process but rather a hamartomatous process. Meningothelial hamartoma is an exceedingly rare, benign lesion that may be confused with a low-grade vascular neoplasm due to its rare nature and unusual histologic features.
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Nepali, R., G. Banita, and G. Thakur. "Fine needle aspiration cytology of thyroid swellings: Experience in a tertiary care hospital of Nepal." Bangladesh Journal of Otorhinolaryngology 18, no. 2 (November 24, 2012): 119–23. http://dx.doi.org/10.3329/bjo.v18i2.11984.
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Introduction: Fine Needle Aspiration Cytology (FNAC) being a minimally invasive technique, is particularly suitable in the sensitive neck area. FNAC can obviate the need for surgery if the lesion is shown to be non neoplastic or if it confirms suspected recurrent tumor. A preoperative cytological diagnosis of a primary neoplasm of thyroid may allow more rational planning of surgery.Method: This descriptive observational study was carried out at the Department of ENT- Head & Neck Surgery, Gandaki Medical College and Charak Hospital, Pokhara, Nepal, from August 2010 to November 2011. A total of 154 consecutive FNAC of thyroid swellings was included.Results: Out of 154 patients female were 142 (92%) and men were 12 (8%). In this series of 154 thyroid swellings on FNAC one hundred and thirty six (88%) were non neoplastic and eighteen (12%) neoplastic. Among non neoplastic thyroid swelling, adenoma was the most common sixty two (40%), followed by colloid cyst, Hashimoto thypoiditis, subacute thyroiditis, adenoma, cystic lesion, Gravess disease, thyroglossal cyst and lymphocytic thyroiditis. Among neoplastic thyroid swelling papillary carcinoma was the commonest nine (5.8%) followed by follicular neoplasm six (3.9%).Conclusion: It is concluded from the present study that female in our region were more affected, non-neoplastic lesions of the thyroid were more common (colloid goiter being the commonest) than neoplastic lesions (papillary carcinoma being the commonest). DOI:http://dx.doi.org/10.3329/bjo.v18i2.11984 Bangladesh J Otorhinolaryngol 2012; 18(2): 119-123
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Sigounas, Dimitrios, Amanullah Shams, Peter Hayes, and John Plevris. "Endoscopic ultrasound assessment of gastrointestinal polypoid lesions of indeterminate morphology in patients with portal hypertension." Endoscopy International Open 06, no. 03 (March 2018): E292—E299. http://dx.doi.org/10.1055/s-0043-124363.
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Abstract Background and study aims Polypoid lesions found during upper gastrointestinal endoscopy (UGIE) are occasionally found in patients with portal hypertension (PH). This study aimed to assess the true nature of such polypoid lesions using endoscopic ultrasound (EUS) and determine the accuracy of UGIE in differentiating between vascular and non-vascular lesions in PH. Patients and methods We retrospectively assessed all patients with PH referred for EUS due to polypoid lesions of unknown nature at UGIE over a 7-year period. Cases of known varices were excluded. UGIE findings were compared to EUS findings. Results 66 patients were included (26 male). Commonest UGIE findings were: possible varices (19.4 %), polypoid/neoplastic lesion (52.8 %) and submucosal lesion (16.7 %). After EUS, the final diagnoses were: varices in 25 %, polypoid lesion with underlying vessel/varix in 27.8 % and non-vascular lesion or submucosal lesion in 47.2 %. The diagnostic accuracy of UGIE was suboptimal, since 28.6 % of possible varices were eventually found to be non-vascular, while 15.8 % of polyp/neoplastic looking lesions proved to be varices and 42.1 % were lesions with underlying vessel/varix. 50 % of submucosal lesions were eventually found to be varices. Conclusion Endoscopists should have a high index of suspicion of varices or polyps related to varices when assessing atypical looking polypoid lesions in patients with PH. In such cases EUS should be considered before obtaining biopsies.
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Shrestha, Manisha, Dipti Gautam, Prakriti Shah, and Prateek Krishna Shrestha. "Histopathological Spectrum of Non-neoplastic and Neoplastic Lesions of Urinary Bladder." Nepalese Medical Journal 4, no. 2 (December 31, 2021): 473–77. http://dx.doi.org/10.3126/nmj.v4i2.41353.
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Introduction: Urinary bladder is a site of various non-neoplastic and neoplastic lesions, both of which can present with hematuria. Cystoscopy allows for direct visualization of the bladder mucosa and also obtaining tissue for histopathologic evaluation. The most common non-neoplastic and neoplastic lesion of the urinary bladder is non-specific cystitis and urothelial carcinoma respectively. Materials and methods: This study is a 4-year retrospective study conducted in the Department of Pathology at Patan Hospital, Nepal. All cases from the urinary bladder i.e., both cystoscopic and cystectomy samples were included in the study. Hematoxylin and eosin-stained slides were re-evaluated whenever required. Results: A total of 145 cases were included which consisted of 17 cystectomy specimens and 128 cystoscopic biopsies. There was a male predominance. The non-neoplastic and neoplastic cases consisted of 32% and 68% respectively. Chronic non-specific cystitis and high-grade infiltrating urothelial carcinoma were the most common non-neoplastic and neoplastic lesions respectively. 56.1% of cystoscopic biopsies had the presence of detrusor muscle with 21.7% showing its invasion. Conclusions: Urinary bladder lesions have a wide spectrum ranging from non-neoplastic to neoplastic conditions. The presence of detrusor muscle in a cystoscopic biopsy, and its evaluation for invasion helps in diagnosis and further planning of patient management.
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Palliyalil, Shayfa, and Mini B. "Histomorphologic and Immunohistochemical Study of Lymph-Node Biopsies in Generalised Lymphadenopathy." Journal of Evidence Based Medicine and Healthcare 8, no. 07 (February 15, 2021): 364–68. http://dx.doi.org/10.18410/jebmh/2021/71.
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BACKGROUND “Lymphadenopathy’’ refers to nodes that are abnormal in size, consistency, or number. It is designated as generalised’’ if lymph-nodes are enlarged in two or more non-contiguous areas. Approximately three fourths of patients presenting with unexplained lymph-node enlargement have localised lymphadenopathy, whereas one fourth have generalised lymphadenopathy. In the present study an attempt is made to identify and categorise various neoplastic versus nonneoplastic lesions in patients presenting with generalised lymphadenopathy in a tertiary care centre.METHODS A cross sectional study of 100 lymph-node biopsies was conducted. After adequate fixation in 10 % formalin, tissues were routinely processed and stained with haematoxylin and eosin (H & E). Special stains like Ziehl-Neelsen and reticulin were employed whenever indicated. Immunohistochemistry (IHC) was performed for all neoplastic lesions and for some cases of non-neoplastic lesions. RESULTS Amongst 100 cases of lymph node biopsies analysed in this study, 71 cases were non-neoplastic and 29 were neoplastic. The most common non-neoplastic lesion observed was granulomatous lymphadenitis (32 cases), followed by reactive lymphadenitis (20). 25 cases of non-Hodgkin lymphoma (NHL) and 4 cases of Hodgkin lymphoma were observed in the neoplastic group. In the age range of 4.5 to 77 years included in the study, major bulk of cases was found in the age group of 11 - 20 years; out of this, 78.9 % were non neoplastic and 21.1 % were neoplastic. It was observed that 100 % of cases in the age group below 10 years were non-neoplastic, whereas in the age group above 70 years, all cases were neoplastic. CONCLUSIONS Granulomatous lymphadenitis was the most common lesion observed, probably because of high incidence of tuberculosis in this part of state. Morphological evaluation by light microscopy supplemented by special stains and IHC are necessary for establishing final diagnosis of generalised lymphadenopathy. KEYWORDS Generalised Lymphadenopathy, Haematoxylin and Eosin, IHC, Granulomatous Lymphadenitis, Kikuchi Fujimoto Lymphadenopathy, Hodgkin Lymphoma, NonHodgkin Lymphoma
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Tabassum, Farzana, Zafor M. Masud, Taslima Hossain, and Saiyeda Sinthia Karim. "The role of the initial modality in the investigation of thyroid lesions." International Journal of Research in Medical Sciences 11, no. 3 (February 28, 2023): 819–23. http://dx.doi.org/10.18203/2320-6012.ijrms20230566.
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Background: Partial or complete thyroidectomies are frequently encountered via the working towards pathologist and the opportunity of neoplastic disease is of principal problem in patients with thyroid nodules. Pathological comparison of these specimens ranged from non-neoplastic lesion to exceedingly aggressive malignancy. The aim of this study is to assess the role of the initial modality in the investigation of thyroid lesions. Methods: This is an observational study. The study used to be carried out in the admitted patient’s department of histopathology, National institute of ear, nose and throat, Dhaka. Bangladesh. In Bangladesh for the duration of the period from June 2021 to May 2022. Results: This study shows that according to 301 patients where, most of the patients in initial modality in the investigation of thyroid lesions 95 (31.56%) were 40 to 49 years and the minimum sex distribution of study 105 (34.88%) belongs to males. Non-neoplastic of goiter were 194 (64.45%), benign cyst was 43 (14.29%), DeQuervains (Subacute) thyroiditis 11 (3.65%), Lymphocytic thyroiditis were 8 (2.65%) and hashimoto thyroiditis were 3 (1.0%). And acfemalesg to neoplastic of papillary carcinoma were 30 (9.97%), Follicular neoplasm were 9 (2.99%) and Anaplastic carcinoma were 3 (1.0%). Conclusions: Thyroid lesions are more common in female. The majority of the thyroid nodules are either non-neoplastic or benign neoplasm. Thyroid lesions present a dependable analysis and is an incredible first line technique for investigating the nature of lesion.
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Akhtar, Zahid Mahmood, Madiha Arshad, and Rabia Altaf. "Frequency of Thyroid Lesions at Pathology Department of King Edward Medical University Lahore." Pakistan Journal of Medical and Health Sciences 16, no. 3 (March 26, 2022): 146–48. http://dx.doi.org/10.53350/pjmhs22163146.
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Background: Thyroid gland is notorious for carrying commonest endocrine pathologies and also for commonest endocrine malignancy. It is the 5th most common cancer in human beings. This makes to carry out current study to get insight of frequency of thyroid lesions at tertiary care level. Methods: This was a descriptive cross-sectional study. The study was done at the Department of Pathology, King Edward Medical University Lahore with the collaboration of four surgical units of Mayo Hospital Lahore from 2010 to 2019. Total 1601 cases were included. Information about age, sex and diagnosis was entered in the pre designed proforma. SPSS version 22 was used for data analysis. Descriptive analysis was done and the results were presented as frequencies, percentages and ratios. The results were then studied against local and international data. Results: This study revealed non neoplastic and neoplastic lesions as 1323 (82.63%) and 278 (17.37%) respectively. Bulk of the lesions 61.6% were between the age bracket of 20-39 years. Mean±SD for age was 34.22±11.42 years. Female to male ratio(F:M) was in favour of females as 9.81:1. Among the non neoplastic lesions, MNG 1151(87%) was a dominant lesion followed by TH 82(6%). LT 29(2.19%) and HT 26(1.96%) were other important lesions. F:M ratio was 10.80:1. Neoplastic lesions were divided into benign 178(64%) and malignant tumors 100(36%). FA was the leading benign neoplasm 164(59%). Rest of the benign tumors shared a minor fraction except HCA 12(4.31%). Among the malignant category, Papillary carcinoma 69(24.82%) dominated over MC 12(4.31%). FC 7(2.51%) and AC 6(2.15%) were other significant findings. F:M ratio in malignancy was 3.16:1 which was significantly lower than 13.83:1 in benign tumors. Conclusion: MNG is the dominant lesion among the non neoplastic lesions while in the neoplastic category FA was leading as benign neoplasm. Papillary carcinoma turned out to be the commonest malignant tumor. Major share of all the lesions were seen between 20-39 years. Keywords: MNG, Papillary carcinoma, Follicular adenoma, neoplastic lesions