Journal articles on the topic 'Neoplasms'
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1
Keller, Evan T., and Bruce R. Madewell. "Locations and types of neoplasms in immature dogs: 69 cases (1964-1989)." Journal of the American Veterinary Medical Association 200, no. 10 (May 15, 1992): 1530–32. http://dx.doi.org/10.2460/javma.1992.200.10.1530.
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Summary Sites, histologic types, and frequencies of neoplasms in immature dogs (≤6 months old) were evaluated from data collected over 25 years. The frequencies of neoplasms in immature dogs were compared with those of mature dogs (>6 months old). Of 69 immature dogs with neoplasms, 5 had 2 primary neoplasms each, resulting in a total of 74 neoplasms. The 3 most common sites for neoplasia, in decreasing order, were the hematopoietic system, brain, and skin. Immature dogs were 10.9 times more likely to have a neoplasm located in the brain, compared with mature dogs. Immature dogs also were 3.3 times more likely to have a neoplasm associated with the hematopoietic system, compared with mature dogs.
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Hasoon Mohammad ,, Salam, and Ruaa A Salman. "Statistical Study of Cancer in Diyala Provenance." Diyala Journal of Medicine 23, no. 1 (October 15, 2022): 80–87. http://dx.doi.org/10.26505/djm.v23i1.928.
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Background: Malignant neoplasms are a group of illnesses involving altered cell proliferation with the ability to invade or metastasize to other sites of the body. Not all neoplasms are malignant; benign neoplasms do not metastasize to other parts of the body.
Objective: To To find out and subcategorize different types of malignant neoplasms in the Diyala and find the relationship with different criteria, including age, sex, grade….,etc.
Patients and Methods: In order to conduct this retrospective study, 158 patients with malignant neoplasmas were chosen from the pathology laboratories spread throughout Provenance-Baquba City between February 2012 and December 2016. For all cases, we do statistical analysis for age, gender, tissue affected, type of surgery, kind of malignant neoplasm, grade, stage, and history of diagnosis and find the relationship of each of these factors with each other.
Results: The highest kind of malignant neoplasm within the study was mammary carcinoma, which comprised 39 (24.9%); then dermal malignant neoplasm was 30 (18.9%); and malignant lymphoma was 12 (7.8%); the rest of the other 76 are other malignant neoplasms (48.4%).
Conclusion: Mammary carcinoma is the most common malignant neoplasm in the Diyala Region (25 %), followed by dermal carcinoma (19%), and malignant lymphoma (8 %). Age (51–60 years) is a risk factor for malignant neoplasms in the Diyala Region.
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Hasoon Mohammad, Salam, and Ruaa A Salman. "Statistical Study of Cancer in Diyala Provenance." Diyala Journal of Medicine 23, no. 1 (October 15, 2022): 80–87. http://dx.doi.org/10.26505/djm.23016520510.
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Background: Malignant neoplasms are a group of illnesses involving altered cell proliferation with the ability to invade or metastasize to other sites of the body. Not all neoplasms are malignant; benign neoplasms do not metastasize to other parts of the body. Objective: To To find out and subcategorize different types of malignant neoplasms in the Diyala and find the relationship with different criteria, including age, sex, grade….,etc. Patients and Methods: In order to conduct this retrospective study, 158 patients with malignant neoplasmas were chosen from the pathology laboratories spread throughout Provenance-Baquba City between February 2012 and December 2016. For all cases, we do statistical analysis for age, gender, tissue affected, type of surgery, kind of malignant neoplasm, grade, stage, and history of diagnosis and find the relationship of each of these factors with each other. Results: The highest kind of malignant neoplasm within the study was mammary carcinoma, which comprised 39 (24.9%); then dermal malignant neoplasm was 30 (18.9%); and malignant lymphoma was 12 (7.8%); the rest of the other 76 are other malignant neoplasms (48.4%). Conclusion: Mammary carcinoma is the most common malignant neoplasm in the Diyala Region (25 %), followed by dermal carcinoma (19%), and malignant lymphoma (8 %). Age (51–60 years) is a risk factor for malignant neoplasms in the Diyala Region.
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Luiz Silva, Jhuan, Flávio Henrique Rodrigues Stante, Fernanda Gosuen Gonçalves Dias, and Marcela Aldrovani. "A Retrospective Study of Neoplasms in Dogs and Cats Attended at the Veterinary Hospital of the University of Franca." Ensaios e Ciência C Biológicas Agrárias e da Saúde 27, no. 3 (November 29, 2023): 282–88. http://dx.doi.org/10.17921/1415-6938.2023v27n3p282-288.
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The aim of this study was to conduct a retrospective analysis of a database created from the histopathological analyses performed on dogs and cats treated at the University of Franca Veterinary Hospital (UNIFRAN), describing the frequencies of different diagnosed neoplasms. For that, a total of 1.312 biopsy cases from animals treated between 2018 and 2021 were reviewed, with 228 corresponding to neoplasms in dogs and 39 to neoplasms in cats. The research used classification data regarding the histogenesis and malignancy of neoplasms. All morphological diagnoses contained in the records were considered, with 297 diagnoses included in the study due to some dogs having more than one pathological process. The study found that neoplasms were more frequent among mixed-breed dogs and cats. For dogs, breast carcinomas represented the most frequent neoplasms (27.33%), with a focus on grade I mixed tumor breast carcinoma (7.42%). For cats, squamous cell carcinoma was the most prevalent neoplasm, accounting for 51.28% of all diagnosed cases. The data generated by retrospective clinical studies like this one are important in updating the frequencies of different neoplasms that can affect domestic animals and determining the possible factors involved in neoplastic processes. Keywords: Carcinoma. Veterinary Medicine. Oncology. Tumor ResumoObjetivou-se, com o presente estudo, realizar uma análise retrospectiva de um banco de dados criado a partir das análises histopatológicas realizadas em cães e gatos atendidos no Hospital Veterinário da Universidade de Franca (UNIFRAN), descrevendo as frequências das diferentes neoplasias diagnosticadas. Para isso, foram revisados 1.312 casos de biópsias de animais atendidos entre 2018 e 2021, dos quais 228 corresponderam a neoplasias em cães e 39 a neoplasias em gatos. Utilizou-se no estudo dados de classificação referentes à histogênese e à malignidade das neoplasias. Todos os diagnósticos morfológicos constantes nos registros foram considerados. Alguns cães apresentaram mais de um processo patológico, totalizando 297 diagnósticos incluídos na pesquisa. Neste estudo, neoplasias foram mais frequentes entre cães e gatos sem raça definida. Para cães, os carcinomas mamários representaram as neoplasias mais frequentes (27,33%) com destaque para o carcinoma mamário em tumor misto grau I (7,42%). Para gatos, o carcinoma de células escamosas foi a neoplasia mais prevalente do estudo, representando 51,28% do total de casos diagnosticados. Dados gerados por estudos clínicos retrospectivos como o nosso são importantes para atualizar sobre as frequências dos diferentes tipos que podem acometer as espécies domésticas, auxiliando na determinação dos possíveis fatores envolvidos nos processos neoplásicos. Palavras-chave: Carcinoma. Medicina Veterinária. Oncologia. Tumor.
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Ruiz, Emmanuel Stephano Bracho, Carlos Mata Quintero, Cuauhtemoc Aguilar Barragan, Daniela Rodriguez Ramirez, Sergio Sandoval Tapia, Esmaragdo Huerta Villeda, Esteban Jaime Laurean, et al. "Appendiceal Mucinous Incidental Neoplasm a Rare Case Report and Literature Review." South Asian Research Journal of Applied Medical Sciences 5, no. 06 (December 5, 2023): 158–62. http://dx.doi.org/10.36346/sarjams.2023.v05i06.005.
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Mucinous appendiceal tumors consist of mucinous adenocarcinoma, low-grade appendiceal mucinous neoplasm, and high-grade appendiceal mucinous neoplasm. The incidence of non-mucinous adenocarcinomas is reduced. The most recent edition of the World Health Organization classification and recent consensus guidelines will enable the consistent application of agreed nomenclature. Not only is precise diagnosis essential for effective patient management, but it also facilitates the comparison of results across centers and tumor registries. The most prevalent benign adenoma in the appendix is serrated. It is imperative to differentiate these conditions from low-grade appendiceal mucinous neoplasms, as the latter can also resemble harmless ailments. Adenocarcinomas of the goblet cells are a rare subtype of appendiceal neoplasm. While appendiceal neoplasms are uncommon, they are not entirely so, and even the most seasoned pathologists may find them difficult to diagnose. In addition, appendiceal neoplasia classification and terminology have been subjects of contention for decades. Nonmucinous appendiceal neoplasms are less prevalent than mucinous tumors, and their association with other appendiceal neoplasm subtypes remains uncertain. A literature review of appendiceal mucinous neoplasms identified during laparoscopic appendicectomies is presented here.
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Ozcan, Kerem, and David S. Klimstra. "A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract." Archives of Pathology & Laboratory Medicine 146, no. 3 (February 22, 2022): 298–311. http://dx.doi.org/10.5858/arpa.2021-0399-ra.
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Context.— Although most pancreatic and bile duct neoplasms are solid, mucinous cystic neoplasms and intraductal neoplasms have been increasingly recognized even when clinically silent, thanks to the increased use of sensitive imaging techniques. Cystic and intraductal neoplasms of the pancreas are often resectable and curable and constitute about 5% of all pancreatic neoplasms. Owing to their preinvasive nature and different biology, recognition of these entities remains a major priority. Mucinous cystic neoplasms are histologically and clinically distinct from other cystic pancreatic neoplasms. Pancreatic intraductal neoplasms encompass 3 major entities: intraductal papillary mucinous neoplasm, intraductal oncocytic papillary neoplasm, and intraductal tubulopapillary neoplasm. Intraductal papillary neoplasms of bile ducts are also preinvasive mass-forming neoplasms with both similarities and differences with their pancreatic counterparts. All of these pancreatobiliary neoplasms have diverse and distinctive clinicopathologic, genetic, and prognostic variations. Objective.— To review the clinical, pathologic, and molecular features of mucinous cystic and intraductal neoplasms of the pancreatobiliary tract. Data Sources.— Literature review, diagnostic manuals, and guidelines. Conclusions.— This review will briefly describe well-known clinical and pathologic features and will focus on selected recently described aspects of morphology, grading, classification, and genomic alterations of cystic and intraductal neoplasms of the pancreatobiliary tract.
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Argenta, Fernando Froner, Paula Reis Pereira, Rafaela Albuquerque Caprioli, Andréia Vielmo, Luciana Sonne, Saulo Petinatti Pavarini, and David Driemeier. "Testicular Neoplasms in Dogs in Rio Grande do Sul, Brazil." Acta Scientiae Veterinariae 44, no. 1 (March 19, 2018): 6. http://dx.doi.org/10.22456/1679-9216.81288.
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Background: Testicular neoplasms are common in dogs, and their incidence is higher in older animals, and in cases of cryptorchidism. In general, they are benign and rarely metastasize. The aim of this study is to determine the frequency of testicular neoplasms in dogs in the Departament of Veterinary Pathology of the Universidade Federal do Rio Grande do Sul (SPV-UFGRS) in the period of January 2005 to December 2015. Materials, Methods & Results: Histopathological examination records of dogs conducted from January 2005 to December 2015 on SPV-UFRGS were reviewed searching for cases of testicular neoplasms in dogs. The general data of the dogs were analyzed, such as age, clinical history and clinical signs, when reported according to the requester. The classification of neoplasms in this study followed the histological criteria established by the World Health Organization. In the period studied, 4,764 biopsies were processed from male dogs, 305 (6.4%) of them were diagnosed with testicular neoplasms. The mean age range was 11.1 year-old. In 260 dogs, the neoplasms have affected a single testicle, and in 45, they were bilateral. From 305 dogs, 247 had a single neoplasm, while 58 dogs have developed more than one type of neoplasm, at once, totaling 415 diagnosis of testicular neoplasms. The most prevalent testicular neoplasms were Leydig cell tumor, followed by seminoma, and sertoli cell tumor, representing 50.8%, 35.2% and 14% respectively. Forty-five animals presented bilateral testicular neoplasms single or multiple, totaling 104 diagnoses. Leydig cell tumor was the most frequent bilateral neoplasm. Fifty dogs developed neoplasms in cryptorchid or ectopic testicles, representing 24.4% of cases with reported clinical data. Of these, nine were located in the inguinal region, nine in the subcutaneous, intra-abdominal 12, and in 20 cases the location was not informed. In these cases the mean age range was 9.5 year-old. Clinical signs of hyperestrogenism were reported in 4.9% of cases and histological changes of malignancy were reported in 5.5% of all diagnoses. Discussion: The frequency of testicular neoplasms in dogs in this study, and the average age, were similar to several studies. Leydig cell tumor, seminoma and sertoli cell tumor are the most common testicular neoplasms diagnosed in this paper, as described in some studies. Data relating to bilateral and multiple neoplasms cases are similar to several researchers. The combination of seminoma with Leydig cell tumor was the most frequent in this study, similar to the literature. The occurrence of cryptorchidism in dogs was described in 24.4% of cases while similar studies reported frequency of 4.5% to 56.3%. Histological changes with malignancy characteristics were described in 5.5% of all cases of this study, and were predominantly characterized by invasion of neoplasic cells into the lymphatic and blood vessels, of these, 95.6% were seminomas and 4.4% sertoliomas. This information agrees with researchers that reported that metastases occur in less than 15% of sertoli cell tumor or seminomas. Clinical manifestations of feminization were infrequent in cases of testicular neoplasms in dogs of this paper, and the sertolioma is the neoplasm most commonly associated with manifestations of hyperestrogenism. As described in literature, over 50% of dogs with sertoli cell tumor show signs of feminization, but most of the cases are asymptomatic, and often an incidental finding at the time of physical examination.Background: Testicular neoplasms are common in dogs, and their incidence is higher in older animals, and in cases of cryptorchidism. In general, they are benign and rarely metastasize. The aim of this study is to determine the frequency of testicular neoplasms in dogs in the Departament of Veterinary Pathology of the Universidade Federal do Rio Grande do Sul (SPV-UFGRS) in the period of January 2005 to December 2015.Materials, Methods & Results: Histopathological examination records of dogs conducted from January 2005 to December 2015 on SPV-UFRGS were reviewed searching for cases of testicular neoplasms in dogs. The general data of the dogs were analyzed, such as age, clinical history and clinical signs, when reported according to the requester. The classification of neoplasms in this study followed the histological criteria established by the World Health Organization. In the period studied, 4,764 biopsies were processed from male dogs, 305 (6.4%) of them were diagnosed with testicular neoplasms. The mean age range was 11.1 year-old. In 260 dogs, the neoplasms have affected a single testicle, and in 45, they were bilateral. From 305 dogs, 247 had a single neoplasm, while 58 dogs have developed more than one type of neoplasm, at once, totaling 415 diagnosis of testicular neoplasms. The most prevalent testicular neoplasms were Leydig cell tumor, followed by seminoma, and sertoli cell tumor, representing 50.8%, 35.2% and 14% respectively. Forty-five animals presented bilateral testicular neoplasms single or multiple, totaling 104 diagnoses. Leydig cell tumor was the most frequent bilateral neoplasm. Fifty dogs developed neoplasms in cryptorchid or ectopic testicles, representing 24.4% of cases with reported clinical data. Of these, nine were located in the inguinal region, nine in the subcutaneous, intra-abdominal 12, and in 20 cases the location was not informed. In these cases the mean age range was 9.5 year-old. Clinical signs of hyperestrogenism were reported in 4.9% of cases and histological changes of malignancy were reported in 5.5% of all diagnoses.Discussion: The frequency of testicular neoplasms in dogs in this study, and the average age, were similar to several studies. Leydig cell tumor, seminoma and sertoli cell tumor are the most common testicular neoplasms diagnosed in this paper, as described in some studies. Data relating to bilateral and multiple neoplasms cases are similar to several researchers. The combination of seminoma with Leydig cell tumor was the most frequent in this study, similar to the literature. The occurrence of cryptorchidism in dogs was described in 24.4% of cases while similar studies reported frequency of 4.5% to 56.3%. Histological changes with malignancy characteristics were described in 5.5% of all cases of this study, and were predominantly characterized by invasion of neoplasic cells into the lymphatic and blood vessels, of these, 95.6% were seminomas and 4.4% sertoliomas. This information agrees with researchers that reported that metastases occur in less than 15% of sertoli cell tumor or seminomas. Clinical manifestations of feminization were infrequent in cases of testicular neoplasms in dogs of this paper, and the sertolioma is the neoplasm most commonly associated with manifestations of hyperestrogenism. As described in literature, over 50% of dogs with sertoli cell tumor show signs of feminization, but most of the cases are asymptomatic, and often an incidental finding at the time of physical examination.
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Muñoz-Duque, Julián D., María C. Ramírez-Rojas, Santiago Duque-Arias, and Nathalia M. Correa-Valencia. "Eye-related neoplasms in dogs: A retrospective study." Revista Colombiana de Ciencias Pecuarias 32, no. 4 (November 7, 2019): 298–311. http://dx.doi.org/10.17533/udea.rccp.v32n4a07.
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Background: Eye-related neoplasms in dogs have a significant impact on visual ability, comfort, and longevity. Therapeutic alternatives and prognosis vary according to type of neoplasm and its anatomical location. Objective: To describe the frequency and distribution of eye-related neoplasms affecting dogs in Aburrá valley (Antioquia province, Colombia). Methods: A retrospective collection of eye-related neoplasms in dogs, diagnosed at the Animal Pathology Laboratory of Universidad de Antioquia (Colombia), was conducted. Data spanning from years 2005 to 2017 were used. Records included age, sex, breed, neoplasm type and location, and cellular origin of neoplasm. A total of 250 eye-related-neoplasm reports affecting 246 dogs were analyzed -one report per animal, with the exception of four animals with both eyes simultaneously affected by the same type of neoplasm. Results: Animals between 8 and 11 years of age were more frequently affected by eye-related neoplasms (43.9%). Labrador retriever (19.1%), mixed-breed dogs (13.4%), and Poodle (12.2%) were the most frequently affected breeds. Neoplasms affected the eyelid in 76.8% of cases. Meibomian gland adenoma was the most frequent neoplasm (22.8%), followed by Meibomian gland epithelioma (20.0%), squamous cell carcinoma (8.8%), and melanocytoma (7.2%). The cellular origin of neoplasms [i]was epithelial in 73.6% of the cases. Conclusion: Meibomian gland adenoma was the most common eye-related neoplasm. To our knowledge, this is the first retrospective report aimed to eye-related neoplasms in dogs published in Colombia.
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Kim, Hyunsung, and Jae Y. Ro. "Intraductal Tubulopapillary Neoplasm of the Pancreas: An Overview." Archives of Pathology & Laboratory Medicine 142, no. 3 (March 1, 2018): 420–23. http://dx.doi.org/10.5858/arpa.2016-0405-rsr2.
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Intraductal tubulopapillary neoplasm is a rare tumor that the World Health Organization recognized in 2010 as a subtype of premalignant pancreatic neoplasms. It is important to distinguish it from other intraductal neoplasms, including intraductal papillary mucinous neoplasm, pancreatic ductal adenocarcinoma, and intraductal variant of acinar cell carcinoma, because intraductal tubulopapillary neoplasm has a favorable prognosis. Histopathologically, intraductal tubulopapillary neoplasms are characterized by tubulopapillary growth, uniform high-grade cytologic atypia, frequent necrotic foci, evident ductal differentiation, and absence of mucin. Intraductal tubulopapillary neoplasms show distinct immunohistochemical and molecular findings, with positive cytokeratin 7, cytokeratin 19, MUC1, and MUC6, and somatic PIK3CA mutations (2 of 11; 18%), and low rates of KRAS (2 of 20; 10%), TP53 (5 of 22; 23%), and BRAF (2 of 13; 15%) mutations. These differences also highlight the fact that intraductal tubulopapillary pancreatic neoplasm is distinct from other similar neoplasms.
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Ionut-Eduard, Iordache, Costea Dan, Grama Mirela, Neacsu Sabina, Steriu Liliana, Leopa Nicoleta, Baltatescu Gabriela, Tomulescu Maria, and Popescu Razvan. "Etiopathogenic Correlations in Breast Cancer." ARS Medica Tomitana 25, no. 3 (August 1, 2019): 100–106. http://dx.doi.org/10.2478/arsm-2019-0021.
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Abstract The classic treatises, as well as the latest studies regarding the breast neoplasms emphasize the importance of several favorable factors in the genesis of the breast neoplasm. The physiological personal history (age of the patient, age of first menstruation, late menopause, late-life sex, reduced breastfeeding, etc.), the personal pathological history, the heredocolateral history (breast, uterine neoplasia, other neoplasms) play a significant role, as well as the living and working conditions (stress, smoking, coffee, alcohol consumption), and dietary factors (hyper-lipidemic and hypoproteinemia regimens). In order to evaluate the impact of these factors in the etiopathogenesis of breast cancer, we fol-lowed their incidence in a prospective study performed on the cases of breast neoplasm hospital-ized and surgically performed in the period between 2012-2018 in the 1st Surgery Clinic.
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Ruivo, Evelyn Aline Boscolo, Juliana Rodrigues Correia Mello, Odete Mauad Cavenaghi, Alexandre Lins Werneck, and Lucas Lima Ferreira. "Respiratory muscle strength of patients with esophagus and stomach neoplasms." Fisioterapia em Movimento 30, suppl 1 (2017): 131–38. http://dx.doi.org/10.1590/1980-5918.030.s01.ao13.
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Abstract Introduction: In cancer patients, the reduced food intake causes weight loss and promotes protein-calorie malnutrition. This results in loss of lean body mass, which affects both skeletal muscles and respiratory muscles. Objective: Evaluate and compare the respiratory muscle strength of patients with esophageal and stomach neoplasia during the preoperative period. Methods: This is a cross-sectional study carried out with 24 patients of both genders hospitalized in a teaching hospital. They underwent a physical therapy evaluation composed of anthropometric data and measurement of respiratory muscle strength through manovacuometry. Paired and unpaired t-tests were used to compare the values obtained with the predicted equations. Results: Regarding the disease prevalence, 66.66%(16) of the individuals had stomach neoplasm and 33.33%(8) esophageal neoplasm. Of the patients with esophageal neoplasm, 100% were men with a mean age of 63 ± 9.16 years. Of those with stomach neoplasm, 68.75% were men with a mean age of 69.36 ± 10.92 years. Female patients with stomach neoplasm had significantly higher BMI (p = 0.01) than male patients, and they were classified as overweight. Both neoplasms had significantly lower real values (p ≤ 0.05) than predicted values at the maximal expiratory pressure. Conclusion: Patients with esophageal and stomach neoplasms in the preoperative period present reduction in the expiratory muscle strength. There were no statistically significant differences, when we compared the maximum respiratory pressures between the two types of neoplasms investigated.
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Bitencourt, Evandro Leite, Paulo Martins Reis Júnior, Renata Rossato, and Bruno de Oliveira Araújo Sousa. "INCIDÊNCIA DE ÓBITOS POR NEOPLASIAS, SEGUNDO LOCALIZAÇÃO PRIMÁRIA DO TUMOR NO ESTADO DO TOCANTINS DE 2006 A 2015." Revista de Patologia do Tocantins 5, no. 3 (September 9, 2018): 5–11. http://dx.doi.org/10.20873/uft.2446-6492.2018v5n3p5.
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Objetivo: Fazer um levantamento de óbitos ocorridos por neoplasias segundo a localização primária do tumor no Estado do Tocantins de 2006 a 2015. Métodos: Os dados foram obtidos através de acesso ao sítio do Instituto Nacional do Câncer (INCA). A seleção dos dados foi feita de acordo com a Classificação Estatística Internacional de Doenças e Problemas Relacionados com a Saúde (CID-10) 10ª edição. O grande grupo do CID-10 selecionado foi o de Neoplasias [tumores] malignas (os) que engloba os CID de C-00 a C97. Resultados: As neoplasias que causaram maior mortalidade no Estado do Tocantins foram a neoplasia maligna de brônquios e pulmões seguida pela localização primária desconhecida, neoplasias malignas da próstata, mama, esôfago, estômago, pâncreas, fígado, colo do útero e leucemia mieloide. Quanto à faixa etária, a idade que registrou o maior número de óbitos foi de 70 a 79 anos. Conclusões: Com essa pesquisa, observa-se semelhança entre o perfil da mortalidade por neoplasias no Estado do Tocantins e o Brasil. Deve ser incentivada a criação de políticas públicas voltadas a essa patologia e conscientização da população na tentativa de evitar essa alta mortalidade.
Palavras-chave: Óbitos; Neoplasias; Sistemas de informação.
ABSTRACT
Objective: To make a survey of deaths due to neoplasms according to the primary location of the tumor in the state of Tocantins from 2006 to 2015. Methods: Data were obtained through access to the National Cancer Institute (INCA) website. Data were selected according to the International Statistical Classification of Diseases and Related Health Problems (ICD-10) 10th edition. The large group of ICD-10 selected was that of malignant neoplasms [tumors] that encompasses ICDs from C-00 to C97. Results: The neoplasms that caused the greatest mortality in the State of Tocantins were malignant neoplasms of the bronchi and lungs followed by the unknown primary site, malignant neoplasms of the prostate, breast, esophagus, stomach, pancreas, liver, cervix and myeloid leukemia. As for the age group, the age with the highest number of deaths was 70 to 79 years. Conclusions: With this research, there is a similarity between the profile of mortality due to neoplasms in the state of Tocantins and Brazil. It should be encouraged the creation of public policies aimed at this pathology and public awareness in an attempt to avoid such high mortality.
Keywords: Deaths; Neoplasms; Information systems.
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Batts, Tifini L., Emi Sasaki, Mayzie Miller, Joshua Sparago, Rudy W. Bauer, Daniel Paulsen, Bonnie Boudreaux, Chin-Chi Liu, Stephanie D. Byrum, and Andrea N. Johnston. "Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue." PLOS ONE 18, no. 1 (January 25, 2023): e0280928. http://dx.doi.org/10.1371/journal.pone.0280928.
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Hepatobiliary neuroendocrine neoplasms are rare cancers in humans and dogs. To date, no large-scale primary hepatobiliary neoplasm omics analyses exist in any species. This limits the development of diagnostic biomarkers and targeted therapeutics. Neuroendocrine cancers are a heterogenous group of neoplasms categorized by their tissue-of-origin. Because the anatomic niche of neuroendocrine neoplasms shapes tumor phenotype, we sought to compare the proteomes of 3 canine hepatobiliary neoplasms to normal hepatobiliary tissue and adrenal glands with the objective of identifying unique protein signatures. Protein was extracted from formalin-fixed paraffin-embedded samples and submitted for tandem mass spectroscopy. Thirty-two upregulated and 126 downregulated differentially expressed proteins were identified. Remarkably, 6 (19%) of the upregulated proteins are correlated to non-hepatobiliary neuroendocrine neoplasia and 16 (50%) are functionally annotated within the exosome cellular compartment key to neuroendocrine signaling. Twenty-six (21%) downregulated proteins are enriched in metabolic pathways consistent with alterations in cancer. These results suggests that characteristic neoplastic protein signatures can be gleaned from small data sets using a comparative proteomics approach.
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Odenweller, Patrick H., Mark M. Smith, and Kendall G. Taney. "Validation of Regional Lymph Node Excisional Biopsy for Staging Oral and Maxillofacial Malignant Neoplasms in 97 Dogs and 10 Cats (2006-2016)." Journal of Veterinary Dentistry 36, no. 2 (June 2019): 97–103. http://dx.doi.org/10.1177/0898756419869841.
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The objective of this retrospective clinical study was to confirm the validity of excisional biopsy of regional lymphocentrums for staging oral and maxillofacial neoplasms in a population of 97 dogs and 10 cats. Patients diagnosed with oral and maxillofacial malignant neoplasms underwent ipsilateral excisional biopsy of the mandibular, parotid, and medial retropharyngeal lymphocentrums that receive afferent drainage from the oral and maxillofacial region followed by curative intent surgery of the neoplasm. Biopsy specimens and the resected neoplasm were submitted to a commercial pathology laboratory for histopathologic assessment. The incidence of metastasis to one or more regional lymphocentrums was 14.0%. Of the cases with metastatic disease, 26.7% did not involve the mandibular lymphocentrum. Although the incidence of regional lymph node metastasis was less than reported previously, regional lymph node assessment is warranted in cases of oral and maxillofacial neoplasia.
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Oliva, Fernando Cascelli, Gabriel José Dos Santos, Gustavo Hideki Hideki Orikasa, Milena Martello Cristófalo, Rafael Reis dos Santos, Beatriz Souza dos Santos, Felipe Giacobo Nunes, et al. "Tumor de Frantz: desafios diagnósticos e terapêuticos: relato de caso / Frantz’s tumor: diagnostic and therapeutic challenges: case report." Arquivos Médicos dos Hospitais e da Faculdade de Ciências Médicas da Santa Casa de São Paulo 64, no. 1 (May 6, 2019): 65. http://dx.doi.org/10.26432/1809-3019.2019.64.1.065.
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Introdução: O tumor sólido pseudopapilar do pâncreas ou Tumor de Frantz, é uma neoplasia rara, que acomete preferencialmente mulheres jovens e apresenta bom prognóstico, com baixas taxas de mortalidade. Relato de Caso: O presente trabalho apresenta um caso de uma paciente da Santa Casa de São Paulo, com Tumor de Frantz, seu diagnóstico, tratamento e complicações pós pancreatectomia.Descritores: Pâncreas, Neoplasias pancreáticas, Carcinoma papilar, Pseudocisto pancreático, Fístula pancreáticaAbstractIntroduction: The solid pseudopapillary tumor, or Frantz’s tumor, is a rare neoplasm that occurs mainly in young women and have a good prognosis, with a low mortality rate. Case report: This study aims to describe the diagnosis, treatment and post pancreatectomy complications of a Frantz’s tumor case in Santa Casa of São Paulo.Keywords: Pancreas, Pancreatic neoplasms; Carcinoma, pappilary; Pancreatic pseudocyst; Pancreatic fistula
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Kővári, Bence, Sándor Turkevi-Nagy, Gregory Y. Lauwers, and Kun Jiang. "Mixed Intraepithelial Neoplasia—Well-Differentiated Neuroendocrine Tumor of the Gallbladder: A Hitherto Unreported Combination." International Journal of Surgical Pathology 29, no. 6 (January 9, 2021): 685–89. http://dx.doi.org/10.1177/1066896920986987.
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Adenocarcinomas and noninvasive intraepithelial neoplasms (either polypoid or flat) are the most common gallbladder tumors; however, neuroendocrine neoplasms (NENs) can also occur. The majority of NENs are represented by neuroendocrine carcinomas (NECs), while neuroendocrine tumors (NETs) are extremely rare in this location. Occasionally, NEN may present as a part of a mixed neoplasm, with a coexisting non-neuroendocrine component. The latest World Health Organization classification denotes these lesions as mixed neuroendocrine–non-NENs (MiNENs). A novel type of MiNEN, the mixed adenoma well-differentiated NET (MANET), has been increasingly recognized and reported. In such lesions, a dysplastic noninvasive neoplasm and a NET represent the exocrine and endocrine component, respectively. MANETs have mostly been identified in the colon, small intestines, and stomach. In this article, we report, we believe, the first case of mixed gallbladder neoplasm with both biliary intraepithelial neoplasia (BilIN) and NET components, which may be regarded as a variant of MANET. Given the expectably favorable prognoses of MANETs, it is imperative not to misdiagnose the infiltrative yet indolent neuroendocrine component as an invasive adenocarcinoma or a NEC.
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Meesuwan, Sirilak, Donruethai Sreta, Rachan Uppaicha, and Dettachai Ketpun. "Histopathologic prevalence of benign and malignant canine neoplasms in small animal hospital, Rajamangala University of Technology Tawan-Ok, Chonburi, Thailand: A retrospective study." Veterinary Integrative Sciences 21, no. 1 (November 7, 2022): 239–50. http://dx.doi.org/10.12982/vis.2023.019.
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This retrospective study surveyed the histological prevalence of 180 canine neoplasms registered during 2016-2020 in the small animal hospital, the Rajamangala University of Technology Tawan-Ok, Chonburi, Thailand. Histopathologic diagnosis of each neoplasia was performed using its published diagnosis criteria. The neoplasms were categorized into epithelial, mesenchymal and round-cell neoplasms. Their parameters were related to sex, breed, and neoplastic location. The study consequence revealed that benign neoplasms occurred in the same frequency as malignant neoplasia. Some neoplasms were sex-dependent, particularly mammary adenocarcinoma in females and perianal (hepatoid) gland adenoma in males. The purebred dogs were prone to the malignant mammary gland and benign mesenchymal neoplasia; meanwhile, the crossbred dogs had more frequencies of benign epithelial, benign round cell and malignant mesenchymal neoplasms than the purebreds. The buttock and head were the primary locations of benign epithelial neoplasms. The mammary gland was common for mammary cancers, while the hindlimb was the predilection site of the malignant mesenchymal neoplasia. These results are similar to the thosedescribed in the previous studies from other regions of Thailand and the rest of the world with a few different points. Therefore, regional veterinarians, particularly in Chonburi province, can confidently use our study findings to set up their preliminary diagnoses for their neoplastic patients.
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Marino, G., and R. Marten Perolino. "Bladder carcinoma and respiratory tract neoplastic associations." Urologia Journal 62, no. 1_suppl (January 1995): 155–59. http://dx.doi.org/10.1177/039156039506201s42.
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— From 1991 to April 1995, 490 patients with urogenital tract neoplasms were diagnosed in the Hospital Mauriziano of Turin. 68 (13.9%) patients showed a multiple primary malignant neoplasm (MPMN), of whom 13 had urothelial and respiratory tract neoplasm 13/68 (10.8%): 7 cases of bladder-laryngo neoplasm, 4 of bladder-lung neoplasm, 2 of bladder-nose neoplasm. Similar aetiological factors were involved in these associations (smoking, analgesic abuse and occupational exposure to industrial toxic substances) but the increase was due to correct histopathological classification, increase in single neoplasms (in particular larynx and bladder neoplasms) and increase in survival rate. Progressive reduction in mortality from cancer of the larynx may favour the increase of bladder-larynx neoplasm association recommending extreme vigilance of the patients. The Authors propose to patients with larynx neoplasm a follow-up with cytological urinary tests aimed at early discovery and treatment of the bladder neoplasm.
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Savari, Omid, Hope Hastings, Rania Rayes, and Joseph F. Tomashefski. "Neuroendocrine Neoplasia in Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma) of the Lung: A Case Report and Immunohistochemistry Analysis of Eight Pulmonary MALT Lymphomas." International Journal of Surgical Pathology 26, no. 7 (April 19, 2018): 660–63. http://dx.doi.org/10.1177/1066896918769745.
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Carcinoid tumorlets are peribronchiolar proliferations of neuroendocrine cells often associated with lung scars. Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a non-Hodgkin’s lymphoma that frequently involves the gastrointestinal tract but less commonly is described in the lung. Simultaneous occurrence of neuroendocrine neoplasms and MALT lymphoma is extraordinarily rare and has predominately been reported in the gastrointestinal tract. In this article, we describe the case of a 73-year-old female with coexisting pulmonary MALT lymphoma and carcinoid tumorlets of the right middle lobe. Retrospective series of 8 pulmonary MALT lymphomas are evaluated for neuroendocrine neoplasia by immunohistochemistry. No correlation between MALT lymphoma and neuroendocrine neoplasia was identified in this case series. While the concurrence of these distinctive neoplasms is most likely coincidental, the presence of a common risk factor, or one neoplasm as a risk factor for the other, deserves study of a larger group of pulmonary MALT lymphomas.
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Bejer-Oleńska, Ewa, Michael Thoene, Andrzej Włodarczyk, and Joanna Wojtkiewicz. "Application of MRI for the Diagnosis of Neoplasms." BioMed Research International 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/2715831.
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Aim. The aim of the study was to determine the most commonly diagnosed neoplasms in the MRI scanned patient population and indicate correlations based on the descriptive variables. Methods. The SPSS software was used to determine the incidence of neoplasms within the specific diagnoses based on the descriptive variables of the studied population. Over a five year period, 791 patients and 839 MRI scans were identified in neoplasm category (C00-D48 according to the International Statistical Classification of Diseases and Related Health Problems ICD-10). Results. More women (56%) than men (44%) represented C00-D48. Three categories of neoplasms were recorded. Furthermore, benign neoplasms were the most numerous, diagnosed mainly in patients in the fifth decade of life, and included benign neoplasms of the brain and other parts of the central nervous system. Conclusions. Males ≤ 30 years of age with neoplasms had three times higher MRI scans rate than females of the same age group; even though females had much higher scans rate in every other category. The young males are more often selected for these scans if a neoplasm is suspected. Finally, the number of MRI-diagnosed neoplasms showed a linear annual increase.
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Tachibana, Hirotaka, Takamitsu Morioka, Kazuhiro Daino, Yi Shang, Mari Ogawa, Misuzu Fujita, Akira Matsuura, Hiroyuki Nogawa, Yoshiya Shimada, and Shizuko Kakinuma. "Early induction and increased risk of precursor B-cell neoplasms after exposure of infant or young-adult mice to ionizing radiation." Journal of Radiation Research 61, no. 5 (August 18, 2020): 648–56. http://dx.doi.org/10.1093/jrr/rraa055.
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Abstract Epidemiological studies of atomic-bomb survivors have revealed an increased risk of lymphoid neoplasm (i.e. acute lymphoblastic leukemia) associated with radiation exposure. In particular, children are more susceptible to radiation-induced precursor lymphoid neoplasm than adults. Although ~75% of human lymphoid tumors are B-cell neoplasms, the carcinogenic risk associated with each stage of differentiation of B-cells after radiation exposure is poorly understood. Therefore, we irradiated mice at infancy or in young adulthood to investigate the effect of age at exposure on the risk of developing B-cell neoplasms. Histopathology was used to confirm the presence of lymphoid neoplasms, and the population of B-cell neoplasms was classified into the precursor B-cell (pro-B and pre-B cell) type and mature B-cell type, according to immunophenotype. The data revealed that precursor B-cell neoplasms were induced soon after radiation exposure in infancy or young adulthood, resulting in a greater risk of developing the neoplasms. This was particularly the case for the pro-B cell type after young adult exposure. Our findings suggest that exposure to radiation at young age increases the risk of developing precursor B-cell neoplasms in humans.
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Mustafa, Mohamed, David Priemer, Muhammad Idrees, and Shaoxiong Chen. "Paratesticular Adipocytic Neoplasms Evaluated at a Single Institution." American Journal of Clinical Pathology 152, Supplement_1 (September 11, 2019): S73—S74. http://dx.doi.org/10.1093/ajcp/aqz113.090.
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Abstract Objectives Some of the scrotal masses are extratesticular neoplasias and develop from paratesticular tissues. Paratesticular region has a complex anatomy and contains epididymal and testicular appendages as spermatic cord, testicular tunicas, epididymis, and vestigial remnants. Therefore, neoplasms originating from this region comprise a heterogeneous group of tumors. Herein, we document paratesticular adipocytic neoplasms and the patient’s mean age and the mean size of tumor at presentation. Methods We retrospectively searched our database for paratesticular adipocytic neoplasms from the year 2001 to 2015. A total of 47 cases were identified and reports were reviewed. Results Of the total 47 cases, 28 (60%) spermatic cord lipomas, 9 (19%) well-differentiated liposarcomas, and 10 (21%) dedifferentiated liposarcomas were identified. The mean age for presentation for these diseases was of 41, 59, and 68 years, respectively. Conclusion The most common paratesticular adipocytic neoplasm in our institution is spermatic cord lipoma (60%), occurring in younger age group (mean age 40 years). However, up to 40% cases are malignant and include well-differentiated and dedifferentiated liposarcoma, occurring at a relatively older age population (59 and 68, respectively).
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Cornea, Remus, Sorina Taban, Cristian Suciu, Codruta Lazureanu, and Alis Dema. "Intestinal Heterotopic Pancreas Involved by Simultaneous PanIN-2 Lesion and Endocrine Microadenoma: a Unique Case." Journal of Gastrointestinal and Liver Diseases 26, no. 2 (June 1, 2017): 199–202. http://dx.doi.org/10.15403/jgld.2014.1121.262.pan.
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We hereby present the case of a 58-year-old male who underwent a total gastrectomy for gastric neoplasm. During the surgery, a tumor mass in the jejunum was identified, considered as metastasis, and resected. The histopathological examination of the jejunal lesion showed ectopic pancreas. In this area, two pathological distinct lesions were identified, one histologically compatible with pancreatic intraepithelial neoplasia (PanIN) type 2 lesion and the other with morphologic criteria for endocrine microadenoma. To our knowledge, this is the first case that evidences the presence of a concomitant premalignant exocrine lesion and benign endocrine lesion in a heterotopic pancreas (HP).Abbreviations: HP: heterotopic pancreas; IPMN: Intraductal Papillary Mucinous Neoplasms; PanIN: Pancreatic Intraepithelial Neoplasia; PEN: pancreatic endocrine neoplasm.
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Римская, Е. Н., А. О. Щадько, И. А. Аполлонова, А. П. Николаев, А. Н. Брико, И. А. Дешин, П. Ю. Бережной, et al. "Дифференциация пигментных новообразований кожи на основе цифровой обработки оптических изображений-=SUP=-*-=/SUP=-." Журнал технической физики 126, no. 5 (2019): 584. http://dx.doi.org/10.21883/os.2019.05.47657.6-19.
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A method for differentiation of pigmented skin neoplasms based on digital processing of optical images has been proposed. The optical images are detected using a digital camera and an etalon for its color and spatial calibration. The method implies segmentation and automatic differentiation of neoplasms based on 5 parameters –the diameter, area, color, shape and smoothness of margins of the neoplasm. It reveals clinical features of the neoplasm, required for diagnosis, and allows for calculating a probability of the neoplasms malignizaion. The proposed method has been verified using 360 imaging of pigmented neoplasms of the skin in vivo; among them: ordinary, dysplastic nevi of the skin and skin melanoma. The observed sensitivity and specificity of the proposed technique are 97% and 95%, correspondingly.
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Choe, Jung Wan, Seung Young Kim, Jong Jin Hyun, Sung Woo Jung, Ja Seol Koo, Jong-Jae Park, Hoon Jai Chun, and Sang Woo Lee. "Prevalence of colorectal adenoma in patients with multiple gastric adenoma or cancers." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): 517. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.517.
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517 Background: It has been reported that patients with single gastric cancer or adenoma are at increased risk of colorectal cancer or adenoma. However, the incidence of colorectal adenoma in patients with multiple gastric neoplasms has not been discussed yet. Methods: We retrospectively analyzed the esophagogastroduodenoscopic and colonoscopic findings as well as the clinicopathologic features between October 2012 and July 2014. The aim of this study was to investigate whether the incidence of colorectal adenoma is higher or not in patients with multiple gastric neoplasms than those with a single gastric neoplasm. Results: A total of 164 patients with gastric neoplasm were divided into two groups whether the number of lesions was single or multiple. Among the 138 patients with single gastric neoplasm, 51 patients performed colonoscopy for surveillance study and 9 patients underwent colonoscopy among the 26 patients with multiple gastric neoplasms. Colorectal adenoma were detected in 58.8% (30/51) of the single gastric neoplasm group, and in 88.8% (8/9) of the multiple gastric neoplasms group (p < 0.001). The mean number of colorectal adenomas was significantly higher in the multiple gastric neoplasm group than in the single group. (4.78 vs. 1.94, p = 0.013). The age, sex, BMI, presence of underlying diseases and the degree of gastric dysplasia were not significantly different between the two groups. Conclusions: The prevalence and the number of colorectal adenoma were significantly higher in patients with multiple gastric neoplasms than in those with single gastric neoplasm. Clinical trial information: KUGH14308-001.
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Moharram, Inas, Walaa Awadin, Mohamed Hamed, M. Salem, and E. Mosbah. "A survey of tumors affecting cattle, buffaloes and sheep, in El-Dakahlyia Governorate." Mansoura Veterinary Medical Journal 20, no. 2 (June 25, 2019): 70–78. http://dx.doi.org/10.35943/mvmj.2019.22.107.
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In a 2-year survey of tumors occurring in ruminants reared in El-Dakahlyia Governorate, Egypt during the period from October 2016 to October 2018. 66 tumor masses were collected: 60 from cattle, 2 from buffaloes and 4 from sheep. According to histopathology of cattle tumors, 15 neoplasms were diagnosed as cutaneous papilloma, 5 neoplasms were diagnosed as cutaneous fibropapillomas, 25 neoplasms were diagnosed as squamous-cell carcinoma (SCC) of the eye; 8 neoplasms were diagnosed as SCC of perineum, 1 neoplasm was diagnosed as SCC in skin of muzzle, 2 neoplasms were diagnosed as epulis in dental pad, 2 neoplasms were diagnosed as vaginal leiomyoma, 1 neoplasm was diagnosed as fibroma and 1 neoplasm was diagnosed as liposarcoma. Histopathology of buffalo tumors revealed SCC in head skin (1 case) and buccal cavity (1 case). Histopathology of sheep tumors revealed SCC in skin under the tail (2 cases), skin of groin (1 case) and skin of abdomen (1 case). In conclusion, cattle (60/66) were more susceptible to tumors than buffaloes (2/66) and sheep (4/66). Females accounted for a higher percentage of the neoplasms (47/66) than males (19/66). Adult animals aged above 2 years were more frequently affected than young. The occurrence of epithelial tumors (60/66) was greater than the mesenchymal tumors (6/66). The most common epithelial tumors were ocular SCC and cutaneous papilloma. Number of malignant tumors (41/66) was higher than number of benign tumors (25/66). Variable degrees of bovine SCC differentiation were detected. Meanwhile ovine SCC appeared only well differentiated.
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Stebbins, K. E., C. C. Morse, and M. H. Goldschmidt. "Feline Oral Neoplasia: A Ten-Year Survey." Veterinary Pathology 26, no. 2 (March 1989): 121–28. http://dx.doi.org/10.1177/030098588902600204.
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A retrospective histological study was conducted on 371 neoplasms of the oral cavity in cats. Oral neoplasia accounted for 10% of feline neoplasms identified during the survey period. Eighty-nine percent of the oral neoplasms were malignant. Twenty different oral neoplasms were found. The most common were squamous cell carcinoma (61.2%), fibrosarcoma (12.9%), and fibromatous epulis of periodontal ligament origin (7.8%).
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Papadimitriou, Ilias, Efstratios Vakirlis, Elena Sotiriou, Katerina Bakirtzi, Aimilios Lallas, and Demetrios Ioannides. "Sebaceous Neoplasms." Diagnostics 13, no. 10 (May 9, 2023): 1676. http://dx.doi.org/10.3390/diagnostics13101676.
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Sebaceous neoplasms describe a group of tumors with sebaceous differentiation commonly seen in lesions located primarily in the face and neck. The majority of these lesions are benign, while malignant neoplasms with sebaceous differentiation are uncommon. Sebaceous tumors present a strong association with the Muir–Torre Syndrome. Patients suspected with this syndrome should undergo neoplasm excision, followed by histopathologic and additional immunohistochemistry and genetics examinations. Clinical and dermoscopic features of the sebaceous neoplasms, as well as management procedures collected from the literature analysis regarding sebaceous carcinoma, sebaceoma/sebaceous adenoma, and sebaceous hyperplasia are described in the current review. A special note is made for describing the Muir–Torre Syndrome in patients presenting multiple sebaceous tumors.
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Sergi, Consolato M., Marta Rojas-Vasquez, Michelle Noga, and Bryan Dicken. "‘Teratoid’ Hepatoblastoma: An Intriguing Variant of Mixed Epithelial-Mesenchymal Hepatoblastoma." Children 9, no. 4 (April 15, 2022): 565. http://dx.doi.org/10.3390/children9040565.
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Liver neoplasms are quite rare in childhood. They often involve 6.7 cases per 10 million children aged 18 years or younger. Hepatoblastoma (HB) is the most frequent tumor, but this neoplasm’s rarity points essentially to the difficulty of performing biologic studies and large-scale therapeutic trials. On the pathological ground, HB is separated into an entirely epithelial neoplasm or a mixed neoplasm with epithelial and mesenchymal components. This last category has been further subdivided into harboring teratoid features or not. The ‘teratoid’ HB includes a mixture of components with heterologous origin. The heterologous components include neuroectoderm, endoderm, or melanin-holding cells with or without mesenchymal components. The most important criterium for the teratoid component is neuroepithelium, melanin, and, more recently, a yolk-sac-like component and neuroendocrine components. The mesenchymal components include muscle, osteoid, and cartilage, which are most often observed mainly in ‘teratoid’ neoplasms. The teratoid component or mesenchymal components are diagnosed with biopsies. They appear more prominent after chemotherapy due to the response and shrinkage of epithelial elements and non- or low-responsive components of mixed HB. This review focuses on the clinical, radiological, and pathological findings of HB with teratoid features.
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Cantley, Richard L. "Fine-Needle Aspiration Cytology of Cellular Basaloid Neoplasms of the Salivary Gland." Archives of Pathology & Laboratory Medicine 143, no. 11 (September 11, 2019): 1338–45. http://dx.doi.org/10.5858/arpa.2019-0327-ra.
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Context.— Cellular basaloid neoplasms of the salivary gland represent a diverse group of benign and malignant neoplasms with significant cytomorphologic overlap on fine-needle aspiration cytology. All are marked by the presence of monotonous and usually bland basaloid epithelium. Distinction between basaloid neoplasms on fine-needle aspiration cytology is based on the presence or absence of additional features, including a second cell population (eg, myoepithelial cells), an acellular stromal component, and/or cytologic atypia within the basaloid epithelium. This review highlights the cytomorphologic features of the most common cellular basaloid neoplasms of the salivary gland, with an emphasis on classification and subclassification within the Milan System. Objective.— To provide a comprehensive review of the cytologic features of basaloid epithelial neoplasms of the salivary gland, with an emphasis on classification within the Milan System for Reporting Salivary Gland Cytopathology. Data Sources.— Peer-reviewed literature, recent textbooks, and personal experiences of the author. Conclusions.— Some basaloid neoplasms, in particular pleomorphic adenomas and adenoid cystic carcinomas, may have characteristic findings on fine-needle aspiration that allow for definitive diagnosis. In other cases, however, fine-needle aspiration can confirm a neoplastic basaloid process, but specific classification of a benign or malignant neoplasm cannot be rendered. The Milan System for Reporting Salivary Gland Cytopathology acknowledges this difficulty, and recommends benign or malignant classification only when definitive diagnostic features of a specific neoplasm are present. For indeterminate cases, the subcategorization of salivary neoplasm of uncertain malignant potential is recommended.
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Sherpa, Palzum, and Shiva Raj KC. "Histopathological Evaluation of Skin Neoplasms." Nepalese Medical Journal 1, no. 2 (December 2, 2018): 89–93. http://dx.doi.org/10.3126/nmj.v1i2.21591.
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Introduction: Skin tumor incidence has increased over the last several decades. A wide range of tumors are encountered in clinical practice. Accurate identification of skin lesions is vital in ensuring malignancies are not missed and that they are treated early to avoid morbidity and mortality.Materials and Methods: A retrospective cross sectional hospital based study on a series of cases was performed in the Department of Pathology, Patan Academy of Health Sciences, Patan Hospital, Lalitpur, Nepal from April 2011 to March 2016. Data from the histopathology database were analyzed using SPSS version 16.0.Results: During the study period, 410 skin biopsies were received, of which 214 (52.2%) were skin neoplasms. Among them, 175 (81.8%) were benign and 39 (18.2%) were malignant neoplasms. Incidence of keratinocytic tumors was highest followed by soft tissue tumors and melanocytic tumors. Intradermal nevus was the most common benign neoplasm. Among the malignant neoplasms, squamous cell carcinoma was most prevalent (46.1%) followed by basal cell carcinoma (15.3%). Skin neoplasms were present in all age groups with maximum number of benign neoplasms prevalent in 21-30 years and malignant in 51-60 years age group. Mean age was 38 years and 58 years for benign and malignant neoplasms respectively.Conclusions: Histopathological evaluation of skin biopsy is an important tool in diagnosis of skin neoplasms. Intradermal nevus and squamous cell carcinoma was the most common benign and malignant neoplasm respectively. Malignant neoplasms were more common in older patients.
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Gao, Juehua, Shunyou Gong, and Yi-Hua Chen. "Myeloid Neoplasm With Germline Predisposition: A 2016 Update for Pathologists." Archives of Pathology & Laboratory Medicine 143, no. 1 (January 26, 2018): 13–22. http://dx.doi.org/10.5858/arpa.2017-0194-ra.
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Context.— Myeloid neoplasms with familial occurrence have been rarely reported in the past. With the advance of molecular technology and better understanding of the molecular pathogenesis of myeloid neoplasms, investigating the genetic causes of familial acute myeloid leukemia or myelodysplastic syndrome has become feasible in the clinical setting. Recent studies have identified a rapidly expanding list of germline mutations associated with increased risks of developing myeloid neoplasm in the affected families. It is important to recognize these entities, as such a diagnosis may dictate a unique approach in clinical management and surveillance for the patients and carriers. Objective.— To raise the awareness of myeloid neoplasms arising in the setting of familial inheritance among practicing pathologists. Data Sources.— Based on recent literature and the 2016 revision of the World Health Organization classification of hematopoietic neoplasms, we provide an up-to-date review of myeloid neoplasm with germline predisposition. Conclusions.— This short review focuses on the clinical, pathologic, and molecular characterization of myeloid neoplasm with germline predisposition. We emphasize the important features that will help practicing pathologists to recognize these newly described entities.
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Cho, Eunae, Chang Hwan Park, and Sung Sun Kim. "A Case of Intracholecystic Papillary Neoplasm of the Gallbladder with a Brief Review of the Literature." Clinical Ultrasound 7, no. 2 (November 30, 2022): 108–13. http://dx.doi.org/10.18525/cu.2022.7.2.108.
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Gallbladder polyps are frequently found on abdominal ultrasonography. Most gallbladder polyps are benign. However, the risk of malignancy increases when the polyp size exceeds 10 mm. The fifth edition of the World Health Organization Classification of tumors proposed three types of preinvasive neoplasms of the gallbladder: adenoma, intracholecystic papillary neoplasm (ICPN), and biliary intraepithelial neoplasia (BilIN). Herein, we report a case of a growing gallbladder polyp that was diagnosed with ICPN after cholecystectomy, along with a brief literature review.
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Moreno-Torres, Víctor, María Martínez-Urbistondo, José Vázquez-Comendador, María Mateos Seirul-lo, Raquel Castejón, Ana Huerta, Pedro Durán-del Campo, Pablo Tutor, and Susana Mellor-Pita. "Higher mortality risk from gynaecological neoplasms and non-Hodgkin’s lymphoma in patients with systemic lupus erythematosus: an observational study from the Spanish National Registry." Lupus Science & Medicine 11, no. 1 (April 2024): e001153. http://dx.doi.org/10.1136/lupus-2024-001153.
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ObjectiveTo evaluate the impact of the different types of neoplasms and lineages on mortality of patients with SLE.MethodsRetrospective and observational comparison of the neoplasm-related deaths in patients with SLE and the general Spanish population reported in the Spanish Hospital Discharge Database. To determine the impact of SLE on the risk of dying from each neoplasm lineage, a binary logistic regression considering age, female sex, tobacco and alcohol consumption, was performed.ResultsDuring 2016–2019, 139 531 in-hospital deaths from neoplasms were certified in Spain (91 in patients with SLE). Patients with SLE presented a lower mortality rate from solid organ neoplasms, (80.2% vs 91.1%, OR 0.393), linked to their lower risk of colorectal carcinoma (1.1% vs 10.8%, OR 0.110). By contrast, gynaecological neoplasms presented a higher risk (8.8% vs 3%, OR 3.039) in the deceased patients with SLE, associated with the higher frequency of vulvar neoplasms (2% vs 0.2%, OR 14.767) and cervical carcinomas (3.3% vs 0.5%, OR 3.809). Haematological neoplasm-related deaths were also more prevalent in patients with SLE (19.8% vs 8.9%, OR 2.546), mostly attributable to the higher proportion of deaths due to non-Hodgkin’s lymphoma (11% vs 2.9%, OR 4.060) of B cell lineage (9.9% vs 2.5%, OR 4.133).ConclusionsPatients with SLE present a higher risk of death from vulvar neoplasms, cervical carcinomas and B-cell non-Hodgkin’s lymphoma in comparison with the general Spanish population. In addition to developing strategies that might help to attenuate their occurrence and impact, such as decreasing the immunosuppressive burden, specific early detection programmes for these conditions should be investigated and considered carefully.
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Miyata, Takashi, Katsuhiko Uesaka, and Yasuni Nakanuma. "Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands." Case Reports in Pathology 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/9130754.
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Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types.Case 1.A 70-year-old man. Radiologically, a cystic tumor measuring 20 mm in diameter was found at the hepatic hilum. Right hepatectomy was performed under a diagnosis of intrahepatic cholangiocarcinoma (iCCA) based on the imaging findings.Case 2.A 70-year-old man. Radiologically, a cystic tumor measuring 60 mm in diameter was found at the hepatic hilum. Under a diagnosis of iCCA, left hepatic trisectionectomy was performed. In both cases, endoscopic retrograde cholangiography did not demonstrate communication between the cystic tumor and adjacent bile ducts. Pathologically, these two tumors were cystic neoplasms located at the hepatic hilum and were morphologically characterized by an intracystic papillary neoplasm composed of diffuse high-grade dysplasia and associated with an invasive carcinoma. Ovarian-like stroma was not found in the capsule of these tumors. Interestingly, there were peribiliary glands near these tumors, and MUC6 was expressed in these papillary neoplasms as well as in the peribiliary glands. These neoplasms might have arisen from the peribiliary glands.
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Shen, Steven S., Luan D. Truong, Marina Scarpelli, and Antonio Lopez-Beltran. "Role of Immunohistochemistry in Diagnosing Renal Neoplasms: When Is It Really Useful?" Archives of Pathology & Laboratory Medicine 136, no. 4 (April 1, 2012): 410–17. http://dx.doi.org/10.5858/arpa.2011-0472-ra.
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Context.—With the refinement of molecular and histologic classifications of renal neoplasms and the availability of more-effective molecular targeted therapy for specific renal neoplasms, immunohistochemical techniques will play an increasingly important role in the diagnosis of renal neoplasm. During the past few decades, many markers have been evaluated for their role in the diagnosis, prognosis, and prediction of treatment for renal neoplasms. The number of useful markers in our routine practice continues to increase. The challenge will be to choose among them and to decide in which situations immunohistochemistry will be truly useful. Objectives.—To review the diagnostic utility of molecular markers for renal neoplasms and common diagnostic scenarios that call for immunohistochemistry in routine practice. Data Sources.—This review is based on published literature and personal experience. Conclusions.—Some of the most important and useful markers for the diagnosis of renal neoplasm include cytokeratins, vimentin, PAX2, PAX8, RCC marker, CD10, E-cadherin, kidney-specific cadherin, parvalbumin, claudin-7, claudin-8, α-methylacyl coenzyme A racemase, CD117, TFE3, thrombomodulin, uroplakin III, p63, CD57, and carbonic anhydrase IX. Each marker has its diagnostic role in a specific diagnostic setting. The common diagnostic situations that call for immunohistochemical staining are differential diagnoses of renal versus nonrenal neoplasms, histologic subtyping of renal cell carcinoma, diagnosis of rare primary renal neoplasms, diagnosis of renal neoplasms in small core-biopsy specimens, diagnosis of possible metastatic renal carcinomas, and less frequently, molecular prognostication.
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Al Shibli, Nasib, Ahmed Badr, and Bader M. N. Albilasi. "Low–Grade Appendiceal Mucinous Neoplasia: A Rare Case Report." European Journal of Medical and Health Sciences 4, no. 5 (October 22, 2022): 38–40. http://dx.doi.org/10.24018/ejmed.2022.4.5.1508.
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Low-grade appendiceal mucinous neoplasms (LAMN) are rarely seen. They are incidentally detected during an appendectomy for appendicitis. Treatment is appendectomy in low-grade appendiceal mucinous neoplasms. Those having adverse features based on the appendix, lymph node metastasis, and tumour size greater than 2 cm, appendectomy with hemicolectomy is done. We present a rare case report of appendiceal neoplasm diagnosed with low-grade appendiceal mucinous neoplasm (LAMN) managed by appendectomy with right hemicolectomy.
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Aronsson, L., B. Andersson, R. Andersson, B. Tingstedt, S. O. Bratlie, and D. Ansari. "Intraductal Papillary Mucinous Neoplasms of The Pancreas: A Nationwide Registry-Based Study." Scandinavian Journal of Surgery 107, no. 4 (April 11, 2018): 302–7. http://dx.doi.org/10.1177/1457496918766727.
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Background and Aims: To investigate the paraclinical and pathological features of surgically resected intraductal papillary mucinous neoplasms in Sweden. Materials and Methods: A review of prospectively collected data on patients undergoing pancreatic resection for a histopathologically verified intraductal papillary mucinous neoplasm between 2010 and 2016 was performed using the Swedish National Registry for Pancreatic and Periampullary Cancer. Results: A total of 3038 pancreatic resections were performed during the study period, of which 251 (8.3%) were due to intraductal papillary mucinous neoplasms. The intraductal papillary mucinous neoplasm cases comprised 227 noninvasive and 24 invasive lesions. There was an annual increase in the number of resected intraductal papillary mucinous neoplasms, from 13 in 2010 to 56 in 2016, and an increase in the proportion of intraductal papillary mucinous neoplasm to the total number of pancreatic resections (4.7%–11%). Biliary obstruction was the only independent predictor of invasive disease, with odds ratio 3.106 (p = 0.030). There was no difference in survival between low-, intermediate-, and high-grade dysplastic lesions (p = 0.417). However, once invasive, the prognosis was severely impacted (p < 0.001). Three-year survival was 90% for noninvasive intraductal papillary mucinous neoplasm and 39% for invasive intraductal papillary mucinous neoplasm. Survival was better in lymph node negative invasive intraductal papillary mucinous neoplasm (p = 0.021), but still dismal compared to noninvasive lesions (p < 0.001). Conclusion: The number of surgically resected intraductal papillary mucinous neoplasms is increasing in Sweden. Biliary obstruction is associated with invasive disease. Low-to-high-grade dysplastic intraductal papillary mucinous neoplasm has an excellent prognosis, while invasive intraductal papillary mucinous neoplasm has a poor survival rate.
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Jammal, Millena Prata, Agrimaldo Martins-Filho, Thales Parenti Silveira, Eddie Fernando Candido Murta, and Rosekeila Simões Nomelini. "Cytokines and Prognostic Factors in Epithelial Ovarian Cancer." Clinical Medicine Insights: Oncology 10 (January 2016): CMO.S38333. http://dx.doi.org/10.4137/cmo.s38333.
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Introduction Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. Method The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms. A panel of cytokines was evaluated by immunohistochemistry (Th1: IL-2 and IL-8; Th2: IL-5, IL-6, and IL-10; and TNFR1). Chi-square test with Yates’ correction was used, which was considered significant if less than 0.05. Results TNFR1, IL-5, and IL-10 had more frequent immunostaining 2/3 in benign neoplasms compared with malignant tumors. Malignant tumors had more frequent immunostaining 2/3 for IL-2 in relation to benign tumors. The immunostaining 0/1 of IL 8 was more frequent in the stroma of benign neoplasms compared with malignant neoplasms. Evaluation of the ovarian cancer stroma showed that histological grade 3 was significantly correlated with staining 2/3 for IL-2 ( P = 0.004). Women whose disease-free survival was less than 2.5 years had TNFR1 stromal staining 2/3 ( P = 0.03) more frequently. Conclusion IL-2 and TNFR1 stromal immunostaining are related prognostic factors in ovarian cancer and can be the target of new therapeutic strategies.
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Rajashree Pradhan, Sajeeb Mondal, Mrinal Sikdar, and Abhishek Bandyopadhyay. "Mucinous neoplasms of the appendix - A clinicopathologic study of 21 cases with special insight into current classification & controversies." Asian Journal of Medical Sciences 14, no. 1 (January 1, 2023): 185–90. http://dx.doi.org/10.3126/ajms.v14i1.46093.
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Background : Appendiceal mucinous neoplasms are rare and heterogenous disease which often clinically present as appendicitis. There are many controversies regarding the classification of mucinous neoplasms of the appendix.
Aims and Objectives: Our aim of this study was to study different types of mucinous neoplasms of appendix based on current ( WHO 2019) classification, their clinical and radiological presentations and controversies regarding their diagnosis.
Materials and Methods: This was a retrospective study done in a tertiary care hospital. We studied clinical presentations of 21 cases along with the histopathological study of respective appendectomy specimens .
Results: Out of 21 cases, 3 (14.28%) cases were serrated polyp, 9 cases (42.85%) were Low grade appendiceal mucinous neoplasm (LAMN), 3 cases (14.28%) were high grade appendiceal neoplasm (HAMN) and 6 (28.57%) cases were mucinous adenocarcinoma. In this study we have discussed in brief about regarding the current classification and controversies of appendiceal mucinous neoplasms.
Conclusion: Mucinous neoplasms of the appendix are complex lesions with many controversies. Oversimplification in the recent classification may add to more complexity. Reintroduction of the old terminology of Mucinous Tumour of Uncertain Malignant Potential might save histopathologists from potential litigation.
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Klimstra, David S., Martha B. Pitman, and Ralph H. Hruban. "An Algorithmic Approach to the Diagnosis of Pancreatic Neoplasms." Archives of Pathology & Laboratory Medicine 133, no. 3 (March 1, 2009): 454–64. http://dx.doi.org/10.5858/133.3.454.
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Abstract Context.—The pancreas gives rise to an array of distinct neoplasms that can be solid, cystic, or intraductal and can recapitulate the various lines of differentiation present in the normal gland. Objective.—To develop an algorithmic approach to the diagnosis of pancreatic neoplasms that simplifies their pathologic evaluation. Data Sources.—We reviewed literature related to the classification of pancreatic neoplasms on the basis of their gross, histologic, and immunohistochemical features. Conclusions.—By using a series of dichotomous decisions, the differential diagnosis of a pancreatic neoplasm can be narrowed, and in cases of the more common neoplasms, accurate classification can be achieved. Uncommon neoplasms not accounted for by this approach are also discussed, and the additional diagnostic information needed for complete pathologic reporting is presented.
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Gabrielle Mascarenhas Canto, Gabrielle, Alana Farias, Murilo De Queiroz Ramos, and Kiyoshi Ferreira Fukutani. "Changing Patterns of Malignant Neoplasm Notifications in Brazil during the COVID-19 Pandemic: a Seasonal Analysis." Journal of Health Sciences 25, no. 3 (October 25, 2023): 183–87. http://dx.doi.org/10.17921/2447-8938.2023v25n3p183-187.
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AbstractThe COVID-19 pandemic has caused delays in the diagnosis, treatment and follow-up of patients with malignant neoplasms (MN). To analyze the distribution pattern of MN cases in Brazil, we collected data in August 2022, provided by the Department of Informatics of the Brazilian Ministry of Health, from 2013 to 2021. The data were organized in Microsoft Excel, the analysis and presentation of the data were made using ggplot and Reshape packages, and temporal patterns and forecast models were obtained by ARIMA method together with aTSA. The results show that the COVID-19 pandemic did not directly impact the notifications of MN cases, but changed the profile of notifications, as in 2018 there was an increase in the diversity of notified neoplasms, and a change in the number of cases in 2019 and 2020. In addition, the distribution between the evaluations of neoplasms was not proportional, showing conversion in 12 (32.4%), decrease in 24 (64.9%) and increase in 1 neoplasm (2.7%). The findings help to understand the new behavior of notifications, demonstrating a pattern similar to the seasonal forecast model, with random or linear trending patterns. This distribution, with a seasonal pattern, shows variability in certain periods of the year, providing important information for early diagnosis and better planning. Data from this research reinforce the need for active screening methods and incentives for preliminary screening for better detection and management of this malignancy. Keywords: Neoplasms. COVID-19. Delayed Diagnosis. ResumoA pandemia de COVID-19 causou atrasos no diagnóstico, tratamento e acompanhamento de pacientes com neoplasias malignas (NM). Para analisar o padrão de distribuição dos casos de MN no Brasil, coletamos dados em agosto de 2022 disponibilizados pelo Departamento de Informática do Ministério da Saúde do Brasil de 2013 a 2021. Os dados foram organizados no Microsoft Excel, a análise e apresentação dos dados foram feitas usando os pacotes ggplot e Reshape, e os padrões temporais e modelos de previsão foram obtidos pelo método ARIMA junto com o aTSA. Os resultados mostram que a pandemia de COVID-19 não impactou diretamente nas notificações dos casos de NM, mas mudou o perfil das notificações, pois em 2018 houve aumento na diversidade de neoplasias notificadas, e mudança no número de casos em 2019 e 2020. Além disso, a distribuição entre as avaliações das neoplasias não foi proporcional, mostrando conversão em 12 (32,4%), diminuição em 24 (64,9%) e aumento em 1 neoplasia (2,7%). As descobertas ajudam a entender o novo comportamento das notificações demonstrando um padrão semelhante ao modelo de previsão sazonal, com padrões de tendência aleatórios ou lineares. Essa distribuição com padrão sazonal, apresenta variabilidade em determinados períodos do ano, fornecendo informações importantes para o diagnóstico precoce e melhor planejamento. Os dados desta pesquisa reforçam a necessidade de métodos de triagem ativa e incentivos à triagem preliminar para melhor detecção e manejo dessa malignidade. Palavras-chave: Neoplasias. COVID-19. Diagnóstico Tardio.
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Mithun, Vijayabasker, Usha Rani Karuppusamy, Nandhini Bala Balasubramanian, and Mahudeswaran Rajan. "A Rare Case of Benign Synchronous Neoplasm of Parotid Salivary Gland." Annals of Pathology and Laboratory Medicine 11, no. 4 (April 15, 2024): C53–58. http://dx.doi.org/10.21276/apalm.3298.
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Introduction Salivary gland neoplasms represent 2–6% of all head and neck neoplasms. Salivary gland neoplasms arising from the major salivary glands are predominantly benign. Pleomorphic adenoma is the most common benign neoplasm of the salivary gland, followed by warthin’s tumour. The synchronous occurrence of both of these neoplasms is rarely described. We present a case of unilateral salivary gland neoplasm with two distinct histological lesions, which were found incidentally during gross examination and confirmed microscopically. Case report A 72-year-old man with complaints of left parotid swelling, which progressively increased in size over the past 6 months. Ultrasound imaging studies and FNAC show features of pleomorphic adenoma, for which the patient underwent surgery, and the specimen was sent for histopathological examination. In the gross examination, a tan-brown area measuring 0.6 cm in greatest dimension was noted in the parotid salivary gland, in addition to the encapsulated grey-brown neoplasm. Histologically, the tan-brown lesion was found to be an intranodal warthin’s tumour along with a pleomorphic adenoma. Conclusion Synchronous neoplasm is a rare entity that can easily be missed in clinical, imaging and even in cytological examinations. Proper histopathological examination of the resected specimens helps in identifying the lesions that were left unrecognized even by imaging studies due to their proximity to the existing neoplasm, as in our case. The use of VTIQ in combination with B-mode ultrasound may be beneficial in detecting the nature of the lesion prior to surgery.
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Joshi, Usha, Sanjay Singh Chufal, Naveen Thapliyal, and Harsh Khetan. "Cytomorphological features of papillary cystadenocarcinoma of parotid gland: A case report with review of literature." CytoJournal 13 (May 25, 2016): 12. http://dx.doi.org/10.4103/1742-6413.182955.
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Papillary cystadenocarcinoma is a very rare slow growing malignant neoplasm characterized by cysts and intraluminal papillary projections. It is defined by WHO as a separate entity. On FNA, cytological features can mimic with various papillary and cystic neoplasms of salivary gland. It is also difficult to distinguish from benign salivary gland neoplasms as it has bland nuclear features. Thus we present cytomorphological features and discuss its differential diagnosis with neoplasms having prominent papillary architecture with review of literature.
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Krylov, A. Yu. "ANALYSIS OF THE STRUCTURE OF INITIALLY-PLURAL MALIGNANT NEOPLASMS IN STOMACH CANCER IN VITEBSK AND GOMEL REGIONS OF BELARUS." Health and Ecology Issues, no. 3 (September 28, 2010): 84–89. http://dx.doi.org/10.51523/2708-6011.2010-7-3-17.
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The structure study of initially-plural malignant neoplasm incidence was performed, one of which was the stomach cancer. The performed study has shown that incidence structure of initially-plural malignant neoplasms in Gomel and Vitebsk regions on the whole was approximately the same. Most often the stomach cancer was combined with malignant neoplasms of skin, colon, lungs, mammary gland. Differences in combinations of malignant neoplasms of separate localizations most possibly reflect age-gender peculiarities in the studied regions.
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Kobayashi, Mayu, Hideo Wada, Shunsuke Fukui, Hiroki Mizutani, Yuhuko Ichikawa, Katsuya Shiraki, Isao Moritani, Hidekazu Inoue, Motomu Shimaoka, and Hideto Shimpo. "A Clot Waveform Analysis Showing a Hypercoagulable State in Patients with Malignant Neoplasms." Journal of Clinical Medicine 10, no. 22 (November 17, 2021): 5352. http://dx.doi.org/10.3390/jcm10225352.
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(1) Objective: hypercoagulability in patients with malignant neoplasm were evaluated to examine the relationship with thrombosis. (2) Methods: clot waveform analysis (CWA)—activated partial thromboplastin time (APTT) and CWA—small amount of tissue factor induced FIX activation (sTF/FIXa) assays were performed in 92 patients with malignant neoplasm and the relationship between hypercoagulability and thrombosis was retrospectively examined. (3) Results: The study population included 92 patients with malignant neoplasms. Twenty-six (28.3%) had thrombotic diseases and 9 (9.8%) patients died within 28 days after the CWA. The peak time of the CWA-APTT could not show hypercoagulability in patients with malignant neoplasms. There were almost no significant differences in the peak times of the sTF/FIXa among patients with malignant neoplasms and healthy volunteers. In contrast, the peak heights of the CWA-sTF/FIXa in patients with various malignant neoplasms were significantly higher than those in healthy volunteers. Furthermore, among patients with malignant neoplasms, the peak heights of the sTF/FIXa in patients with thrombosis were significantly higher than those in patients without thrombosis. (4) Conclusions: although the routine APTT cannot evaluate the hypercoagulability, the peak heights of CWA-sTF/FIXa were significantly high in patients with malignant neoplasms, especially in those with thrombosis, suggesting that an elevated peak height of the CWA-sTF/FIXa may be a risk factor for thrombosis.
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Gilger, Brian C., Susan A. McLaughlin, R. David Whitley, and James C. Wright. "Orbital neoplasms in cats: 21 cases (1974-1990)." Journal of the American Veterinary Medical Association 201, no. 6 (September 15, 1992): 1083–86. http://dx.doi.org/10.2460/javma.1992.201.07.1083.
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Summary Squamous cell carcinoma was the most common neoplasm found in a review of case records of 21 cats with histopathologically confirmed orbital neoplasms. Other neoplasms found were lymphosarcoma, undifferentiated carcinoma, malignant melanoma, adenocarcinoma, fibrosarcoma, chondroma, and hemangiosarcoma. Three (14%) neoplasms were primary, 15 (71%) were secondary, invading the orbit from adjacent tissues, and 3 (14%) were a manifestation of multicentric disease. The most common clinical sign was exophthalmia, followed by chronic epiphora, enophthalmia, and strabismus. Mean survival time after diagnosis was 1.9 months. Ten cats were euthanatized at the time of diagnosis because of extensive disease. Mean survival time of the other 11 cats was 4.3 months. Skull radiography was helpful in diagnosing orbital neoplasms in 8 of 11 cats that had invasion of the orbit by adjacent neoplasms.
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Ito, Tetsuhide, Toshihiko Masui, Izumi Komoto, Ryuichiro Doi, Robert Y. Osamura, Akihiro Sakurai, Masafumi Ikeda, et al. "JNETS clinical practice guidelines for gastroenteropancreatic neuroendocrine neoplasms: diagnosis, treatment, and follow-up: a synopsis." Journal of Gastroenterology 56, no. 11 (September 29, 2021): 1033–44. http://dx.doi.org/10.1007/s00535-021-01827-7.
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AbstractNeuroendocrine neoplasms (NENs) are rare neoplasms that occur in various organs and present with diverse clinical manifestations. Pathological classification is important in the diagnosis of NENs. Treatment strategies must be selected according to the status of differentiation and malignancy by accurately determining whether the neoplasm is functioning or nonfunctioning, degree of disease progression, and presence of metastasis. The newly revised Clinical Practice Guidelines for Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) comprises 5 chapters—diagnosis, pathology, surgical treatment, medical and multidisciplinary treatment, and multiple endocrine neoplasia type 1 (MEN1)/von Hippel–Lindau (VHL) disease—and includes 51 clinical questions and 19 columns. These guidelines aim to provide direction and practical clinical content for the management of GEP-NEN preferentially based on clinically useful reports. These revised guidelines also refer to the new concept of “neuroendocrine tumor” (NET) grade 3, which is based on the 2017 and 2019 WHO criteria; this includes health insurance coverage of somatostatin receptor scintigraphy for NEN, everolimus for lung and gastrointestinal NET, and lanreotide for GEP-NET. The guidelines also newly refer to the diagnosis, treatment, and surveillance of NEN associated with VHL disease and MEN1. The accuracy of these guidelines has been improved by examining and adopting new evidence obtained after the first edition was published.
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Gurusamy, Veeraraghavan, Indumathi Karnan, and Pappathi Sadagopan. "Clear cell sarcoma of kidney: an uncommon paediatric neoplasm-two case reports and review of literature." International Journal of Contemporary Pediatrics 4, no. 1 (December 21, 2016): 264. http://dx.doi.org/10.18203/2349-3291.ijcp20164615.
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Clear cell sarcoma of kidney is an uncommon neoplasm accounting for approximately 5% of all pediatric renal neoplasms, with a peak incidence between 1-3 years of age. Males are most commonly affected (M:F ratio – 2:1). It is a highly malignant neoplasm with a high propensity than other renal neoplasms to metastasize to bones, hence originally called as bone-metastasizing renal tumour of childhood by Marsden and Lawler. We describe here 2 case reports of clear cell sarcoma of kidney.
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E Uchime, Kasiemobi, Luqman A Adebayo, Lateef A Odukoya, Olugbende O Ajayi, and Charles C Anunobi. "Histopathologic patterns of intracranial neoplasms at Lagos University Teaching Hospital, Nigeria. A ten-year hospital-based retrospective study." African Health Sciences 23, no. 1 (April 11, 2023): 492–503. http://dx.doi.org/10.4314/ahs.v23i1.51.
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Background: The most common intracranial neoplasm worldwide is meningioma, followed by gliomas, and then pituitary adenomas. There are geographical differences in the pattern of occurrence of intracranial neoplasms. The purpose of this study is to establish the pattern of occurrence of different histological types of intracranial neoplasms with their age and sex distributions in our environment – Lagos, Nigeria.The histological patterns, age, and gender distributions of all the intracranial neoplasms diagnosed within the study period at the Department of Anatomic and Molecular Pathology, LUTH, Lagos, Nigeria were noted and analysed with SPSS version 23.
Result: There were 296 patients (165 females, 131 males; mean age of 37.0 years) diagnosed with an intracranial neoplasm within the study period. The most frequently diagnosed intracranial neoplasm was meningioma (105 cases; 35%, median age of 42 years, male to female ratio of 1:2.2), followed by pituitary adenoma (78 cases; 26%, median age of 47 years, male to female ratio of 1.3:1), and then gliomas (71 cases; 24%, median age of 28, male to female ratio of 1:1.39).
Conclusion: The result of the study shows pituitary adenoma to be more common than gliomas, unlike what is seen in Caucasians where the reverse is the case.
Keywords: INTRACRANIAL; Neoplasms; Central Nervous System.