Relevant bibliographies by topics / Neoplasms

Academic literature on the topic 'Neoplasms'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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Journal articles on the topic "Neoplasms"

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Keller, Evan T., and Bruce R. Madewell. "Locations and types of neoplasms in immature dogs: 69 cases (1964-1989)." Journal of the American Veterinary Medical Association 200, no. 10 (May 15, 1992): 1530–32. http://dx.doi.org/10.2460/javma.1992.200.10.1530.

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Summary Sites, histologic types, and frequencies of neoplasms in immature dogs (≤6 months old) were evaluated from data collected over 25 years. The frequencies of neoplasms in immature dogs were compared with those of mature dogs (>6 months old). Of 69 immature dogs with neoplasms, 5 had 2 primary neoplasms each, resulting in a total of 74 neoplasms. The 3 most common sites for neoplasia, in decreasing order, were the hematopoietic system, brain, and skin. Immature dogs were 10.9 times more likely to have a neoplasm located in the brain, compared with mature dogs. Immature dogs also were 3.3 times more likely to have a neoplasm associated with the hematopoietic system, compared with mature dogs.
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Hasoon Mohammad ,, Salam, and Ruaa A Salman. "Statistical Study of Cancer in Diyala Provenance." Diyala Journal of Medicine 23, no. 1 (October 15, 2022): 80–87. http://dx.doi.org/10.26505/djm.v23i1.928.

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Background: Malignant neoplasms are a group of illnesses involving altered cell proliferation with the ability to invade or metastasize to other sites of the body. Not all neoplasms are malignant; benign neoplasms do not metastasize to other parts of the body. Objective: To To find out and subcategorize different types of malignant neoplasms in the Diyala and find the relationship with different criteria, including age, sex, grade….,etc. Patients and Methods: In order to conduct this retrospective study, 158 patients with malignant neoplasmas were chosen from the pathology laboratories spread throughout Provenance-Baquba City between February 2012 and December 2016. For all cases, we do statistical analysis for age, gender, tissue affected, type of surgery, kind of malignant neoplasm, grade, stage, and history of diagnosis and find the relationship of each of these factors with each other. Results: The highest kind of malignant neoplasm within the study was mammary carcinoma, which comprised 39 (24.9%); then dermal malignant neoplasm was 30 (18.9%); and malignant lymphoma was 12 (7.8%); the rest of the other 76 are other malignant neoplasms (48.4%). Conclusion: Mammary carcinoma is the most common malignant neoplasm in the Diyala Region (25 %), followed by dermal carcinoma (19%), and malignant lymphoma (8 %). Age (51–60 years) is a risk factor for malignant neoplasms in the Diyala Region.
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Hasoon Mohammad, Salam, and Ruaa A Salman. "Statistical Study of Cancer in Diyala Provenance." Diyala Journal of Medicine 23, no. 1 (October 15, 2022): 80–87. http://dx.doi.org/10.26505/djm.23016520510.

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Background: Malignant neoplasms are a group of illnesses involving altered cell proliferation with the ability to invade or metastasize to other sites of the body. Not all neoplasms are malignant; benign neoplasms do not metastasize to other parts of the body. Objective: To To find out and subcategorize different types of malignant neoplasms in the Diyala and find the relationship with different criteria, including age, sex, grade….,etc. Patients and Methods: In order to conduct this retrospective study, 158 patients with malignant neoplasmas were chosen from the pathology laboratories spread throughout Provenance-Baquba City between February 2012 and December 2016. For all cases, we do statistical analysis for age, gender, tissue affected, type of surgery, kind of malignant neoplasm, grade, stage, and history of diagnosis and find the relationship of each of these factors with each other. Results: The highest kind of malignant neoplasm within the study was mammary carcinoma, which comprised 39 (24.9%); then dermal malignant neoplasm was 30 (18.9%); and malignant lymphoma was 12 (7.8%); the rest of the other 76 are other malignant neoplasms (48.4%). Conclusion: Mammary carcinoma is the most common malignant neoplasm in the Diyala Region (25 %), followed by dermal carcinoma (19%), and malignant lymphoma (8 %). Age (51–60 years) is a risk factor for malignant neoplasms in the Diyala Region.
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Luiz Silva, Jhuan, Flávio Henrique Rodrigues Stante, Fernanda Gosuen Gonçalves Dias, and Marcela Aldrovani. "A Retrospective Study of Neoplasms in Dogs and Cats Attended at the Veterinary Hospital of the University of Franca." Ensaios e Ciência C Biológicas Agrárias e da Saúde 27, no. 3 (November 29, 2023): 282–88. http://dx.doi.org/10.17921/1415-6938.2023v27n3p282-288.

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The aim of this study was to conduct a retrospective analysis of a database created from the histopathological analyses performed on dogs and cats treated at the University of Franca Veterinary Hospital (UNIFRAN), describing the frequencies of different diagnosed neoplasms. For that, a total of 1.312 biopsy cases from animals treated between 2018 and 2021 were reviewed, with 228 corresponding to neoplasms in dogs and 39 to neoplasms in cats. The research used classification data regarding the histogenesis and malignancy of neoplasms. All morphological diagnoses contained in the records were considered, with 297 diagnoses included in the study due to some dogs having more than one pathological process. The study found that neoplasms were more frequent among mixed-breed dogs and cats. For dogs, breast carcinomas represented the most frequent neoplasms (27.33%), with a focus on grade I mixed tumor breast carcinoma (7.42%). For cats, squamous cell carcinoma was the most prevalent neoplasm, accounting for 51.28% of all diagnosed cases. The data generated by retrospective clinical studies like this one are important in updating the frequencies of different neoplasms that can affect domestic animals and determining the possible factors involved in neoplastic processes. Keywords: Carcinoma. Veterinary Medicine. Oncology. Tumor ResumoObjetivou-se, com o presente estudo, realizar uma análise retrospectiva de um banco de dados criado a partir das análises histopatológicas realizadas em cães e gatos atendidos no Hospital Veterinário da Universidade de Franca (UNIFRAN), descrevendo as frequências das diferentes neoplasias diagnosticadas. Para isso, foram revisados 1.312 casos de biópsias de animais atendidos entre 2018 e 2021, dos quais 228 corresponderam a neoplasias em cães e 39 a neoplasias em gatos. Utilizou-se no estudo dados de classificação referentes à histogênese e à malignidade das neoplasias. Todos os diagnósticos morfológicos constantes nos registros foram considerados. Alguns cães apresentaram mais de um processo patológico, totalizando 297 diagnósticos incluídos na pesquisa. Neste estudo, neoplasias foram mais frequentes entre cães e gatos sem raça definida. Para cães, os carcinomas mamários representaram as neoplasias mais frequentes (27,33%) com destaque para o carcinoma mamário em tumor misto grau I (7,42%). Para gatos, o carcinoma de células escamosas foi a neoplasia mais prevalente do estudo, representando 51,28% do total de casos diagnosticados. Dados gerados por estudos clínicos retrospectivos como o nosso são importantes para atualizar sobre as frequências dos diferentes tipos que podem acometer as espécies domésticas, auxiliando na determinação dos possíveis fatores envolvidos nos processos neoplásicos. Palavras-chave: Carcinoma. Medicina Veterinária. Oncologia. Tumor.
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Ruiz, Emmanuel Stephano Bracho, Carlos Mata Quintero, Cuauhtemoc Aguilar Barragan, Daniela Rodriguez Ramirez, Sergio Sandoval Tapia, Esmaragdo Huerta Villeda, Esteban Jaime Laurean, et al. "Appendiceal Mucinous Incidental Neoplasm a Rare Case Report and Literature Review." South Asian Research Journal of Applied Medical Sciences 5, no. 06 (December 5, 2023): 158–62. http://dx.doi.org/10.36346/sarjams.2023.v05i06.005.

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Mucinous appendiceal tumors consist of mucinous adenocarcinoma, low-grade appendiceal mucinous neoplasm, and high-grade appendiceal mucinous neoplasm. The incidence of non-mucinous adenocarcinomas is reduced. The most recent edition of the World Health Organization classification and recent consensus guidelines will enable the consistent application of agreed nomenclature. Not only is precise diagnosis essential for effective patient management, but it also facilitates the comparison of results across centers and tumor registries. The most prevalent benign adenoma in the appendix is serrated. It is imperative to differentiate these conditions from low-grade appendiceal mucinous neoplasms, as the latter can also resemble harmless ailments. Adenocarcinomas of the goblet cells are a rare subtype of appendiceal neoplasm. While appendiceal neoplasms are uncommon, they are not entirely so, and even the most seasoned pathologists may find them difficult to diagnose. In addition, appendiceal neoplasia classification and terminology have been subjects of contention for decades. Nonmucinous appendiceal neoplasms are less prevalent than mucinous tumors, and their association with other appendiceal neoplasm subtypes remains uncertain. A literature review of appendiceal mucinous neoplasms identified during laparoscopic appendicectomies is presented here.
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Ozcan, Kerem, and David S. Klimstra. "A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract." Archives of Pathology & Laboratory Medicine 146, no. 3 (February 22, 2022): 298–311. http://dx.doi.org/10.5858/arpa.2021-0399-ra.

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Context.— Although most pancreatic and bile duct neoplasms are solid, mucinous cystic neoplasms and intraductal neoplasms have been increasingly recognized even when clinically silent, thanks to the increased use of sensitive imaging techniques. Cystic and intraductal neoplasms of the pancreas are often resectable and curable and constitute about 5% of all pancreatic neoplasms. Owing to their preinvasive nature and different biology, recognition of these entities remains a major priority. Mucinous cystic neoplasms are histologically and clinically distinct from other cystic pancreatic neoplasms. Pancreatic intraductal neoplasms encompass 3 major entities: intraductal papillary mucinous neoplasm, intraductal oncocytic papillary neoplasm, and intraductal tubulopapillary neoplasm. Intraductal papillary neoplasms of bile ducts are also preinvasive mass-forming neoplasms with both similarities and differences with their pancreatic counterparts. All of these pancreatobiliary neoplasms have diverse and distinctive clinicopathologic, genetic, and prognostic variations. Objective.— To review the clinical, pathologic, and molecular features of mucinous cystic and intraductal neoplasms of the pancreatobiliary tract. Data Sources.— Literature review, diagnostic manuals, and guidelines. Conclusions.— This review will briefly describe well-known clinical and pathologic features and will focus on selected recently described aspects of morphology, grading, classification, and genomic alterations of cystic and intraductal neoplasms of the pancreatobiliary tract.
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Argenta, Fernando Froner, Paula Reis Pereira, Rafaela Albuquerque Caprioli, Andréia Vielmo, Luciana Sonne, Saulo Petinatti Pavarini, and David Driemeier. "Testicular Neoplasms in Dogs in Rio Grande do Sul, Brazil." Acta Scientiae Veterinariae 44, no. 1 (March 19, 2018): 6. http://dx.doi.org/10.22456/1679-9216.81288.

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Background: Testicular neoplasms are common in dogs, and their incidence is higher in older animals, and in cases of cryptorchidism. In general, they are benign and rarely metastasize. The aim of this study is to determine the frequency of testicular neoplasms in dogs in the Departament of Veterinary Pathology of the Universidade Federal do Rio Grande do Sul (SPV-UFGRS) in the period of January 2005 to December 2015. Materials, Methods & Results: Histopathological examination records of dogs conducted from January 2005 to December 2015 on SPV-UFRGS were reviewed searching for cases of testicular neoplasms in dogs. The general data of the dogs were analyzed, such as age, clinical history and clinical signs, when reported according to the requester. The classification of neoplasms in this study followed the histological criteria established by the World Health Organization. In the period studied, 4,764 biopsies were processed from male dogs, 305 (6.4%) of them were diagnosed with testicular neoplasms. The mean age range was 11.1 year-old. In 260 dogs, the neoplasms have affected a single testicle, and in 45, they were bilateral. From 305 dogs, 247 had a single neoplasm, while 58 dogs have developed more than one type of neoplasm, at once, totaling 415 diagnosis of testicular neoplasms. The most prevalent testicular neoplasms were Leydig cell tumor, followed by seminoma, and sertoli cell tumor, representing 50.8%, 35.2% and 14% respectively. Forty-five animals presented bilateral testicular neoplasms single or multiple, totaling 104 diagnoses. Leydig cell tumor was the most frequent bilateral neoplasm. Fifty dogs developed neoplasms in cryptorchid or ectopic testicles, representing 24.4% of cases with reported clinical data. Of these, nine were located in the inguinal region, nine in the subcutaneous, intra-abdominal 12, and in 20 cases the location was not informed. In these cases the mean age range was 9.5 year-old. Clinical signs of hyperestrogenism were reported in 4.9% of cases and histological changes of malignancy were reported in 5.5% of all diagnoses. Discussion: The frequency of testicular neoplasms in dogs in this study, and the average age, were similar to several studies. Leydig cell tumor, seminoma and sertoli cell tumor are the most common testicular neoplasms diagnosed in this paper, as described in some studies. Data relating to bilateral and multiple neoplasms cases are similar to several researchers. The combination of seminoma with Leydig cell tumor was the most frequent in this study, similar to the literature. The occurrence of cryptorchidism in dogs was described in 24.4% of cases while similar studies reported frequency of 4.5% to 56.3%. Histological changes with malignancy characteristics were described in 5.5% of all cases of this study, and were predominantly characterized by invasion of neoplasic cells into the lymphatic and blood vessels, of these, 95.6% were seminomas and 4.4% sertoliomas. This information agrees with researchers that reported that metastases occur in less than 15% of sertoli cell tumor or seminomas. Clinical manifestations of feminization were infrequent in cases of testicular neoplasms in dogs of this paper, and the sertolioma is the neoplasm most commonly associated with manifestations of hyperestrogenism. As described in literature, over 50% of dogs with sertoli cell tumor show signs of feminization, but most of the cases are asymptomatic, and often an incidental finding at the time of physical examination.Background: Testicular neoplasms are common in dogs, and their incidence is higher in older animals, and in cases of cryptorchidism. In general, they are benign and rarely metastasize. The aim of this study is to determine the frequency of testicular neoplasms in dogs in the Departament of Veterinary Pathology of the Universidade Federal do Rio Grande do Sul (SPV-UFGRS) in the period of January 2005 to December 2015.Materials, Methods & Results: Histopathological examination records of dogs conducted from January 2005 to December 2015 on SPV-UFRGS were reviewed searching for cases of testicular neoplasms in dogs. The general data of the dogs were analyzed, such as age, clinical history and clinical signs, when reported according to the requester. The classification of neoplasms in this study followed the histological criteria established by the World Health Organization. In the period studied, 4,764 biopsies were processed from male dogs, 305 (6.4%) of them were diagnosed with testicular neoplasms. The mean age range was 11.1 year-old. In 260 dogs, the neoplasms have affected a single testicle, and in 45, they were bilateral. From 305 dogs, 247 had a single neoplasm, while 58 dogs have developed more than one type of neoplasm, at once, totaling 415 diagnosis of testicular neoplasms. The most prevalent testicular neoplasms were Leydig cell tumor, followed by seminoma, and sertoli cell tumor, representing 50.8%, 35.2% and 14% respectively. Forty-five animals presented bilateral testicular neoplasms single or multiple, totaling 104 diagnoses. Leydig cell tumor was the most frequent bilateral neoplasm. Fifty dogs developed neoplasms in cryptorchid or ectopic testicles, representing 24.4% of cases with reported clinical data. Of these, nine were located in the inguinal region, nine in the subcutaneous, intra-abdominal 12, and in 20 cases the location was not informed. In these cases the mean age range was 9.5 year-old. Clinical signs of hyperestrogenism were reported in 4.9% of cases and histological changes of malignancy were reported in 5.5% of all diagnoses.Discussion: The frequency of testicular neoplasms in dogs in this study, and the average age, were similar to several studies. Leydig cell tumor, seminoma and sertoli cell tumor are the most common testicular neoplasms diagnosed in this paper, as described in some studies. Data relating to bilateral and multiple neoplasms cases are similar to several researchers. The combination of seminoma with Leydig cell tumor was the most frequent in this study, similar to the literature. The occurrence of cryptorchidism in dogs was described in 24.4% of cases while similar studies reported frequency of 4.5% to 56.3%. Histological changes with malignancy characteristics were described in 5.5% of all cases of this study, and were predominantly characterized by invasion of neoplasic cells into the lymphatic and blood vessels, of these, 95.6% were seminomas and 4.4% sertoliomas. This information agrees with researchers that reported that metastases occur in less than 15% of sertoli cell tumor or seminomas. Clinical manifestations of feminization were infrequent in cases of testicular neoplasms in dogs of this paper, and the sertolioma is the neoplasm most commonly associated with manifestations of hyperestrogenism. As described in literature, over 50% of dogs with sertoli cell tumor show signs of feminization, but most of the cases are asymptomatic, and often an incidental finding at the time of physical examination.
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Muñoz-Duque, Julián D., María C. Ramírez-Rojas, Santiago Duque-Arias, and Nathalia M. Correa-Valencia. "Eye-related neoplasms in dogs: A retrospective study." Revista Colombiana de Ciencias Pecuarias 32, no. 4 (November 7, 2019): 298–311. http://dx.doi.org/10.17533/udea.rccp.v32n4a07.

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Background: Eye-related neoplasms in dogs have a significant impact on visual ability, comfort, and longevity. Therapeutic alternatives and prognosis vary according to type of neoplasm and its anatomical location. Objective: To describe the frequency and distribution of eye-related neoplasms affecting dogs in Aburrá valley (Antioquia province, Colombia). Methods: A retrospective collection of eye-related neoplasms in dogs, diagnosed at the Animal Pathology Laboratory of Universidad de Antioquia (Colombia), was conducted. Data spanning from years 2005 to 2017 were used. Records included age, sex, breed, neoplasm type and location, and cellular origin of neoplasm. A total of 250 eye-related-neoplasm reports affecting 246 dogs were analyzed -one report per animal, with the exception of four animals with both eyes simultaneously affected by the same type of neoplasm. Results: Animals between 8 and 11 years of age were more frequently affected by eye-related neoplasms (43.9%). Labrador retriever (19.1%), mixed-breed dogs (13.4%), and Poodle (12.2%) were the most frequently affected breeds. Neoplasms affected the eyelid in 76.8% of cases. Meibomian gland adenoma was the most frequent neoplasm (22.8%), followed by Meibomian gland epithelioma (20.0%), squamous cell carcinoma (8.8%), and melanocytoma (7.2%). The cellular origin of neoplasms [i]was epithelial in 73.6% of the cases. Conclusion: Meibomian gland adenoma was the most common eye-related neoplasm. To our knowledge, this is the first retrospective report aimed to eye-related neoplasms in dogs published in Colombia.
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Kim, Hyunsung, and Jae Y. Ro. "Intraductal Tubulopapillary Neoplasm of the Pancreas: An Overview." Archives of Pathology & Laboratory Medicine 142, no. 3 (March 1, 2018): 420–23. http://dx.doi.org/10.5858/arpa.2016-0405-rsr2.

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Intraductal tubulopapillary neoplasm is a rare tumor that the World Health Organization recognized in 2010 as a subtype of premalignant pancreatic neoplasms. It is important to distinguish it from other intraductal neoplasms, including intraductal papillary mucinous neoplasm, pancreatic ductal adenocarcinoma, and intraductal variant of acinar cell carcinoma, because intraductal tubulopapillary neoplasm has a favorable prognosis. Histopathologically, intraductal tubulopapillary neoplasms are characterized by tubulopapillary growth, uniform high-grade cytologic atypia, frequent necrotic foci, evident ductal differentiation, and absence of mucin. Intraductal tubulopapillary neoplasms show distinct immunohistochemical and molecular findings, with positive cytokeratin 7, cytokeratin 19, MUC1, and MUC6, and somatic PIK3CA mutations (2 of 11; 18%), and low rates of KRAS (2 of 20; 10%), TP53 (5 of 22; 23%), and BRAF (2 of 13; 15%) mutations. These differences also highlight the fact that intraductal tubulopapillary pancreatic neoplasm is distinct from other similar neoplasms.
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Ionut-Eduard, Iordache, Costea Dan, Grama Mirela, Neacsu Sabina, Steriu Liliana, Leopa Nicoleta, Baltatescu Gabriela, Tomulescu Maria, and Popescu Razvan. "Etiopathogenic Correlations in Breast Cancer." ARS Medica Tomitana 25, no. 3 (August 1, 2019): 100–106. http://dx.doi.org/10.2478/arsm-2019-0021.

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Abstract The classic treatises, as well as the latest studies regarding the breast neoplasms emphasize the importance of several favorable factors in the genesis of the breast neoplasm. The physiological personal history (age of the patient, age of first menstruation, late menopause, late-life sex, reduced breastfeeding, etc.), the personal pathological history, the heredocolateral history (breast, uterine neoplasia, other neoplasms) play a significant role, as well as the living and working conditions (stress, smoking, coffee, alcohol consumption), and dietary factors (hyper-lipidemic and hypoproteinemia regimens). In order to evaluate the impact of these factors in the etiopathogenesis of breast cancer, we fol-lowed their incidence in a prospective study performed on the cases of breast neoplasm hospital-ized and surgically performed in the period between 2012-2018 in the 1st Surgery Clinic.
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Dissertations / Theses on the topic "Neoplasms"

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Furuse, Cristiane [UNESP]. "Análise multifatorial de segundo tumor primário em pacientes com carcinoma espinocelular primário de boca: estudo retrospectivo de 848 casos." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/91425.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O avanço técnico-científico da oncologia nas últimas décadas acarretou em aumento da sobrevida dos pacientes portadores de câncer. Com sobrevida maior, os oncologistas começaram a observar o aumento do número de pacientes que apresentavam outras neoplasias. O objetivo deste estudo foi analisar possíveis fatores demográficos, clínicos e terapêuticos em pacientes com primeiro tumor primário de boca e que desenvolveram um segundo tumor primário (stp). Foram analisados 848 prontuários de pacientes admitidos para tratamento no Departamento de Cirurgia de Cabeça e Pescoço do Hospital do Câncer Antônio Cândido Camargo, no período de janeiro de 1984 a dezembro de 1994. Destes, 126 (14,9%) desenvolveram um stp. A principal localização do stp foi trato aerodigestivo superior com 53 casos (58,7%), estando divididos em: boca com 29 casos (23,0%), faringe com 15 (11,9%) e laringe com 9 (7,1%). As conclusões foram: dados demográficos não interferiram no desenvolvimento do stp, a variável sexo interferiu no prognóstico dos pacientes; pacientes com classificação TNM inicial apresentaram maior probabilidade de desenvolver stp; a categoria T interferiu na sobrevida dos pacientes do Grupo Controle e do Grupo STP, enquanto a categoria N interferiu somente na sobrevida dos pacientes do Grupo Controle; a actinoterapia não interferiu no aparecimento de stp; o tipo de tratamento realizado apresentou importância na sobrevida dos pacientes.
Over the last decades, technical-scientific advances of oncology have brought about an increased survival rate for cancer patients. As a result, oncologists have detected an increased number of patients presenting with other neoplasms. The aim of this study was to analyze possible demographic, clinical and therapeutic factors in patients with mouth fpt who developed a spt. Medical charts of 848 patients neoplasm admitted for treatment at the Head and Neck Surgery Department of the “Hospital do Câncer, Antônio Cândido Camargo”, Brazil, from January of 1984 to December, were analysed. Of these, 126 (14,9%) developed a spt. The main location of the spt was upper aerodigestive tract, with 53 cases (58,7%), being divided in: mouth with 29 cases (23,0%), pharynx with 15 (11,9%) and larynx with 9 (7,1%) cases. The conclusions were: demographic data didn’t interfere in the development of the stp, the variable sex interfered in the prognostic of patients; patient with classification TNM initial have larger probability of developing spt; the category T interfered in the patients’ prognostic in the groups Control and SPT, while the category N only interfered in the patients' prognostic in the Group Control; the radiotheray didn't interfere in the spt emergence; the type of accomplished treatment presented importance in the patients' survival, for being directly related to the clinical stadium.
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Mehrara, Esmaeil. "Quantitative analysis of tumor growth and response to therapy /." Göteborg : Department of Radiation Physics, University of Gothenburg, 2010. http://hdl.handle.net/2077/21548.

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Zhang, Xun. "Genetic and genomic approaches to the study of progression in mammary carcinogenesis /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8445.

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Dahl, Kjell. "Human colorectal cancer : experimental staging and therapeutics /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-154-8/.

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Cunha, Lucas Leite 1987. "Impacto da resposta imunológica no prognóstico do paciente com carcinoma diferenciado de tiroide : da bancada à clínica." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310294.

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Orientador: Laura Sterian Ward, José Vassallo
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: O câncer de tiroide é a neoplasia maligna endócrina mais frequente. Muito embora a maioria destes pacientes apresente boa evolução clínica com as ferramentas terapêuticas atuais, 10-30% evoluirão com doença recorrente e contribuirão para as 1.890 mortes que são estimadas para 2014 nos Estados Unidos . As ciclooxigenases (COX) são um grupo de enzimas que catalisam a formação de prostaglandinas a partir do ácido aracdônico e a atividade de COX2 tem sido implicada na carcinogênese. Nosso grupo demonstrou anteriormente que diferentes células do sistema imunológico infiltram tecidos de cânceres de tiroide. O presente trabalho investigou a presença de marcadores de células do sistema imunológico, bem como marcadores tumorais de perfil inflamatório, procurando marcadores de prognóstico em pacientes com carcinoma diferenciado de tiroide. Foram investigados retrospectivamente 437 pacientes com carcinoma diferenciado da tiroide, cujas amostras de tecido previamente fixadas em formalina e incluidas em blocos de parafina eram mantidas no Banco de Tecidos do A.C.Camargo Cancer Center. Câncer bem diferenciado de tiroide foi diagnosticado em 305 pacientes: 252 com carcinoma papilífero e 53 com carcinoma folicular. Informações clínicas foram obtidas dos prontuários. Obtivemos tecidos de metástases linfonodais ao diagnóstico de 25 pacientes. Para estes casos, fizemos análise pareada entre tecido metastático e tumor primário. Foram investigados marcadores de células imunológicas em áreas intratumorais, incluindo macrófagos associados a tumores (CD68) e subpopulações de linfócitos infiltrantes de tumor, como CD3, CD4, CD8, CD16, CD20, CD45RO, GRANZIMA B, CD69 e CD25. Também foi investigada a expressão de COX2, IL-17A, IL-1'beta', IL-10, IL-6, CD134 e IL-23 nas células tumorais. Entre todos os parâmetros imunológicos avaliados, apenas o enriquecimento de linfócitos CD8+ e expressão de COX2 foram associados à recorrência. A análise multivariada, utilizando o modelo de riscos proporcionais de Cox ajustado para a presença de tiroidite crônica concomitante, identificou CD8+/COX2 como marcador independente de recidiva. Outros marcadores imunoistoquímicos não conseguiram prever o prognóstico dos pacientes. Notamos um aumento da densidade de linfócitos GRANZIMA B+ nas metástases linfonodais se comparado com os respectivos tumores primários. Metástases linfonodais apresentam menor expressão de COX2 e de IL-10. Isto sugere que mecanismos de evasão tumoral estejam diminuídos nos tecidos metastáticos, explicando, pelo menos em parte, por que a presença de metástases linfonodais não seria um excelente marcador de prognóstico nos pacientes com câncer diferenciado de tiroide. Nosso estudo mostrou que o câncer diferenciado de tiroide é infiltrado por múltiplas células do sistema imunológico e que o padrão de infiltração celular parece se associar a características clínicas e anatomopatológicas distintas. Este misto celular infiltrativo, juntamente com a produção de citocinas inflamatórias, cria um perfil de microambiente que é importante na determinação da agressividade tumoral. De fato, a presença de linfócitos T citotóxicos e a expressão de COX2 puderam prever o pior prognóstico dos pacientes estudados. Ainda, observamos que a metástase linfonodal é o sítio onde ocorreria uma resposta imunológica mais efetora e menos evasiva, de forma a determinar de forma mais assertiva um ataque imunológico efetivo coerente com a pouca força da metástase linfonodal como um preditor de prognóstico
Abstract: Thyroid cancer is the most common endocrine malignancy. Although most of these patients experience clinical improvement with current therapeutic tools, 10-30% will develop recurrent disease and contribute to the 1,890 deaths that are estimated for 2014 in the United States. The cyclooxygenase (COX) are a group of enzymes that catalyze the formation of prostaglandins from arachidonic acid and COX2 activity has been implicated in carcinogenesis. Our group previously demonstrated that mixture of immune cells infiltrates tissue of thyroid cancers. The present study investigated the presence of immune cells markers and tumor markers of inflammatory profile, looking for prognostic markers in patients with differentiated thyroid carcinoma. We retrospectively investigated 437 patients with differentiated thyroid carcinoma, whose tissue samples previously fixed in formalin and included in paraffin blocks were kept in the Tissue Bank of the AC Camargo Cancer Center. Well-differentiated thyroid cancer was diagnosed in 305 patients: 252 with papillary carcinoma and 53 with follicular carcinoma. Clinical information was obtained from medical records. We obtained tissue of lymph node metastases at diagnosis of 25 patients. For these cases, we performed a paired analysis of metastatic tissue and primary tumor. Immunological cell markers were investigated in intratumoral areas, including tumor-associated macrophages (CD68) and subpopulations of tumor infiltrating lymphocytes, such as CD3, CD4, CD8, CD16, CD20, CD45RO, GRANZYME B, CD69 and CD25. We also investigated the expression of COX2, IL-17A, IL-1'beta', IL-10, IL-6, IL-23 and CD134 in the tumor cells. Among all the immunological parameters evaluated, only the enrichment of CD8+ lymphocytes and expression of COX2 were associated with recurrence. Multivariate analysis using the Cox model of proportional hazards adjusted for the presence of concurrent chronic lymphocytic thyroiditis, identified CD8+/COX2 as an independent marker for recurrence. Other immunohistochemical markers failed to predict the prognosis of patients. We notice an increase in the density of GRANZYME B + lymphocytes in lymph node metastases when compared with their primary tumors. Lymph node metastases have lower expression of COX2 and IL-10. This suggests that tumor evasion mechanisms are impaired in metastatic tissues, explaining, at least in part, why the presence of lymph node metastases would not be an excellent prognostic marker in patients with differentiated thyroid cancer. Our study showed that the differentiated thyroid cancer is infiltrated by multiple immune cells and that the pattern of cellular infiltration appears to be associated with distinct clinical and pathological characteristics. This infiltrative mixed cell along with the production of inflammatory cytokines, creates a microenvironment profile that is important in determining the tumor aggressiveness. In fact, the presence of cytotoxic T lymphocytes and COX2 expression could predict the worst prognosis of the patients. Still, we found that lymph node metastasis is the place where there would be a more productive immune response and less evasive, favoring and effective immune response. It is fairly coherent with the little strength of lymph node metastasis as a prognostic predictor
Doutorado
Clinica Medica
Doutor em Ciências
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Martling, Anna. "Rectal cancer : staging, radiotherapy and surgery /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-461-5/.

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Júnior, Rosalvo Zosimo Bispo. "Fatores prognósticos da sobrevida no osteossarcoma primário: grau I versus II de Huvos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5140/tde-24022010-153548/.

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O objetivo deste trabalho foi comparar o prognóstico de sobrevida da graduação histológica após efeito da quimioterapia (graus I versus II de Huvos), visando também identificar fatores prognósticos no que diz respeito à sobrevida livre de recidiva local (SLRL), sobrevida livre de metástase (SLM) e sobrevida global (SG), em pacientes portadores de osteossarcoma primário não metastático ao diagnóstico. Vinte e quatro entre 45 pacientes admitidos no Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo IOT/HC/FMUSP, entre 2000 e 2004, foram eleitos para o estudo, segundo os critérios de inclusão e exclusão utilizados. As probabilidades de sobrevida acumuladas foram feitas pela técnica de Kaplan-Meier e os índices I e II de HUVOS comparados pelos testes de Log Rank. A análise multivariada foi feita pela técnica de regressão logística com modelo de risco proporcional de COX e a validade estatística estabelecida para valores de p<0,05. Os graus I e II de Huvos, quando comparados, não foram considerados de valor prognóstico em nenhuma das sobrevidas estudadas (SLRL, SLM e SG). Os fatores adversos que influenciaram o risco de recidiva local e a sobrevida global, na análise univariada foram: subtipo histológico diferente do osteoblástico (p=0,017) e o tamanho tumoral maior que 15 cm (p=0,048). Em relação à SLM o subtipo não osteoblástico (p=0,007) teve um pior prognóstico. O subtipo histológico manteve sua significância na análise multivariada em todas as sobrevidas estudadas
The purpose of this study was to compare the prognostic of survivor of histologic graduation post chemotherapy (Huvos´s grade I versus II), aiming to identify prognostic factors concerning to local recurrence free survival (LRFS), metastases free survival (MFS) and overall survival (OS) in patients with nonmetastatic primary osteosarcoma. This study included 24 patients registred in the Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - Brazil, from 2000 to 2004. Survivor rates were calculed using Kaplan-Meier method. Huvos´s grade (I e II) were compared using the Log Rank test. Cox proportional hazards model was used for multifatorial analysis. Statistical significance was defined as a p value less than 0, 05. The Huvos´s grade I versus II was not significant factor for LRFS, MFS or OS. The adverse factors for LRFS and OS in univariate analysis were nonosteoblastic histologic subtypes (p=0,017) and large tumor (p=0,048). For MFS nonosteoblastic histologic subtypes (p=0,007) had worse prognostic. The histologic subtypes maintained their significance in multivariate testing on all studied survivor
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Ponte, José Ricardo Tuma da. "Papel do bloqueio androgênico no tratamento do câncer de próstata localmente avançado." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-13102014-093704/.

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Apesar de existir novas técnicas e múltiplas alternativas terapêuticas para o câncer de próstata localmente avançado, esta enfermidade se constitui em um grande problema de saúde pública mundial, resultando em índices significativos de morbidade e mortalidade, gerando desta forma um desafio para urologistas e oncologistas. Existem múltiplas e bem sucedidas estratégias de tratamento da doença localizada, tais como: a prostatectomia radical, a radioterapia externa conformacional, a braquiterapia e a crioablação. Em contraste, o tratamento da doença metastática e localmente avançada, freqüentemente necessita da alguma forma de bloqueio hormonal. Não existe consenso em vários aspectos da terapia hormonal para tumores localmente avançados tais como: o tipo de bloqueio androgênico a ser usado, terapia hormonal precoce ou tardia, associação com outras modalidades terapêuticas e o uso de bloqueio intermitente. Foi realizada uma revisão crítica deste tipo de tratamento, bem como as indicações atuais de bloqueio hormonal nos tumores de próstata localmente avançado. Não existem estudos prospectivos e randomizados que comparem as diversas formas de tratamento cirúrgico versus radioterápico do câncer de próstata localmente avançado. A hormonioterapia adjuvante à prostatectomia radical, na doença localmente avançada, parece reduzir a progressão tumoral bioquímica, porém, não há estudo que evidencie melhora na sobrevida livre de metástase ou na sobrevida global. O bloqueio androgênico neoadjuvante à prostatectomia radical aumenta a proporção dos pacientes com doença órgão-confinada e margens cirúrgicas negativas, porém sem efeito nas taxas de falha bioquímica do tratamento. A terapia hormonal adjuvante à radioterapia em pacientes portadores de câncer de próstata localmente avançado oferece vantagens na sobrevida global. A terapia hormonal neoadjuvante à radioterapia, em estudos multicêntricos e randomizados, resulta em melhor controle local do tumor bem como prolonga a sobrevida doença-específica. Não há, porém evidência de melhora na sobrevida global. O tratamento por tempo prolongado com bloqueadores hormonais adjuvante à radioterapia mostrou-se superior em relação à sobrevida global e sobrevida livre de doença quando comparado a um período curto de bloqueio, principalmente em pacientes com tumores indiferenciados (Gleason 8-10). Os análogos LHRH, orquiectomia ou o dietilestilbestrol se mostraram como opções de monoterapia, igualmente eficazes, para os pacientes que iniciam terapia hormonal de primeira linha, no tratamento da doença localmente avançada. Não existe evidência que justifique o bloqueio androgênico máximo como terapia hormonal de primeira linha ao invés de monoterapia. Existem vantagens potenciais na qualidade de vida e nos custos do tratamento quando realizada a ablação intermitente, mas a sua eficácia a longo prazo necessita ser confirmada
Despite new techniques and multiple therapeutic alternatives, locally advanced prostate cancer is a serious public health problem, resulting in significant morbidity and mortality rates, that remains a great challenge for urologists and oncologists. Several therapeutic strategies to treat localized prostate cancer have been successful such as conformational external beam radiation therapy, brachytherapy and cryoablation. In contrast, treatment of metastatic and locally advanced tumors may often involve androgenic suppression. However, there are no consensus on several aspects of hormonal therapy for locally advanced tumors such as the type of antiandrogenic drug to be used, early versus delayed hormonal therapy, association with other therapeutic modalities and the use of intermittent blockade. We set out to critically review important aspects and current indications of hormonal blockade in the locally advanced prostate tumors. There are no prospective and randomized study that compares current forms of surgical treatment versus radiation therapy of locally advanced prostate cancer. After radical prostatectomy, adjuvant hormonal therapy in the locally advanced disease reduces biochemical failure rates, although no benefit has been shown regarding metastatic free survival or overall suvival. Neoadjuvant androgen blockade enhances the proportion of patients with organ-confined disease and negative surgical margins but no benefit is seen regarding biochemical free recurrence. Neoadjuvant hormonal therapy to the radiotherapy improves local tumor control as well as it prolongs the diseasespecific survival, although there are no survival advantage. Adjuvant hormonal therapy offers overall survival advantage in patients with locally advanced prostate cancer treated with radiotherapy Long term adjuvant hormonal blockade offers survival benefit for patients with high Gleason score (8-10). LHRH analogues, bilateral orquiectomy and dietilestilbestrol were shown are equally effective as adjuvant therapy for patients with locally disease advanced. There are evidences that maximum androgenic blockade are not more efficient than monotherapy. Potential quality of life and costs advantages of intermittent ablation could be considered an alternative treatment for this group of patient
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Mori, Naoyoshi. "NK and NK-related neoplasms." Nagoya University School of Medicine, 1999. http://hdl.handle.net/2237/5345.

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Butler, Lisa H. "Chromosome translocations in haematopoietic neoplasms." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360209.

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Books on the topic "Neoplasms"

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Verstovsek, Srdan, and Ayalew Tefferi, eds. Myeloproliferative Neoplasms. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-60761-266-7.

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Antic, Tatjana, and Jerome B. Taxy. Renal Neoplasms. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0431-0.

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Arnold, Andrew, ed. Endocrine Neoplasms. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6355-6.

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Barbui, Tiziano, and Ayalew Tefferi, eds. Myeloproliferative Neoplasms. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-24989-1.

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Andrew, Arnold, ed. Endocrine neoplasms. Boston: Kluwer Academic Publishers, 1997.

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1936-, Cameron John L., ed. Pancreatic neoplasms. Philadelphia: Saunders, 1995.

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L, Cameron John, ed. Pancreatic neoplasms. Philadelphia, PA: W.B. Saunders, 1995.

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Bryan, Haugen, ed. Thyroid neoplasms. Amsterdam: Elsevier, 2005.

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M, Thompson William, ed. Staging neoplasms. Philadelphia: Saunders, 1994.

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Lorsbach, Robert B., and Marwan Yared, eds. Plasma Cell Neoplasms. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42370-8.

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Book chapters on the topic "Neoplasms"

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Michaels, Leslie, and Henrik B. Hellquist. "Vascular Neoplasms; Myogenic Neoplasms." In Ear, Nose and Throat Histopathology, 218–27. London: Springer London, 2001. http://dx.doi.org/10.1007/978-1-4471-0235-9_19.

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Michaels, L. "Vascular Neoplasms; Myogenic Neoplasms." In Ear, Nose and Throat Histopathology, 203–9. London: Springer London, 1987. http://dx.doi.org/10.1007/978-1-4471-3332-2_19.

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Li, Ke-Hua, Thomas Griffin, Neda Nikbakht, Le Qu, Hong-Duo Chen, Chundi He, and Li-Xin Xia. "Neoplasms." In Practical Immunodermatology, 279–96. Dordrecht: Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-024-0902-4_12.

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Michaels, Leslie, and Henrik B. Hellquist. "Neoplasms." In Ear, Nose and Throat Histopathology, 290–300. London: Springer London, 2001. http://dx.doi.org/10.1007/978-1-4471-0235-9_27.

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Dallenbach-Hellweg, Gisela, Dietmar Schmidt, and Friederike Dallenbach. "Neoplasms." In Atlas of Endometrial Histopathology, 145–208. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-01541-0_9.

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Baergen, Rebecca N. "Neoplasms." In Manual of Pathology of the Human Placenta, 415–26. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7494-5_22.

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Moitra, Ethan. "Neoplasms." In Encyclopedia of Clinical Neuropsychology, 1732. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-79948-3_130.

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Michaels, L. "Neoplasms." In Ear, Nose and Throat Histopathology, 273–85. London: Springer London, 1987. http://dx.doi.org/10.1007/978-1-4471-3332-2_27.

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Ács, Nándor, Ferenc G. Bánhidy, and Andrew E. Czeizel. "Neoplasms." In Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy, 111–16. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8620-4_3.

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Gany, Francesca. "Neoplasms." In Encyclopedia of Immigrant Health, 1119–22. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-5659-0_536.

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Conference papers on the topic "Neoplasms"

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Zakharinskaya, O. N., E. E. Korchagin, and O. A. Cherkashin. "EXPERIENCE OF USING THE MEDICAL INFORMATION SYSTEM QMS IN THE IDENTIFICATION OF PROFESSIONAL ONCOPATHOLOGY IN THE KRASNOYARSK REGIONAL CENTER OF OCCUPATIONAL PATHOLOGY." In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-181-184.

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The use of the qMS medical information system expands the possibilities of diagnosing occupational malignant neoplasms using two criteria: a carcinogenically dangerous enterprise and a diagnosis of a malignant neoplasm (ICD 10). The conclusion of an agreement between the KGBUZ «Regional Clinical Hospital» and the KGBUZ «Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky» on cooperation in identifying persons with suspected occupational malignancies using the qMS MIS, consisting in automated information exchange between information systems belonging to each of the parties, makes it possible to solve a socially significant task detection and diagnosis of occupational malignant neoplasms.
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Farias, Nathália dos Santos, Beatriz Silva Silveira, Isabela Mascarenhas de Andrade, Lara Cordeiro Magalhães, Maria Luísa Sousa Weber, and Maria Clara Cotrim Pereira. "Mortality Rate of CNS neoplasms in childhood in Brazil." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.202.

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Background: The variety of tumors of the Central Nervous System (CNS) during childhood is related to heterogenous clinical manifestations and to an important mortality rate (MR). In Brazil, CNS tumors represent the second most incident cancer during childhood and the main cause of death of children between ages 0-9. Objectives: To describe the number of hospitalizations and the MR of CNS neoplasms by childhood age group in Brazil. Design and Methods: This is a descriptive ecological study based on secondary data, obtained from DATASUS. Data were collected regarding the number of hospitalizations and MR by childhood age group due to neoplasm of the CNS in Brazil between the years 2009-2019. Results: A total of 38192 hospitalizations happened, resulting in 5.91% of MR. The highest value of brain’s neoplasms MR was found in children up to 1 year old (9,34%), but when it comes to number of hospitalizations, the group between ages 5-9 had the highest number, both in neoplasms of the brain (9364) and of other parts of the CNS (1767). Conclusions: The present study pointed out that the childhood age group with the lowest number of hospitalizations (less than 1 year) presented simultaneously the highest MR of CNS tumors.
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Luna, Jose Manuel, Ricardo Romero-Mendez, Abel Hernandez-Guerrero, and Francisco Elizalde-Blancas. "Inverse Problem for the Estimation of Skin Cancerous Region Parameters by Thermal Analysis." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-65538.

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Malignant melanoma is the most aggressive skin cancer since it metastasizes rapidly. The existence of a quantitative, non-expensive, and non-invasive diagnostic screening tool for the evaluation of pigmented lesions would be invaluable for the early detection of malignant melanoma. Based on the fact that this cancerous skin lesion has higher metabolism, as well as an increased blood flow, it has been conjectured that it has higher temperature compared to surrounding healthy skin, temperature than can be measured by infrared thermography. Therefore, it is possible to explore the relationship between the characteristics (size and heat produced) of the neoplasm and the resulting temperature distribution on the skin surface to evaluate the development of the lesion. In our investigation the Dual Reciprocity Boundary Element Method (DRBEM) has been coupled to the Simulated Annealing Technique (SAT) in an inverse procedure to estimate simultaneously the depth and heat produced by skin malignant neoplasms at early stages. The SAT was used to estimate neoplasm parameters by minimizing an objective function that involves the skin surface temperature profiles obtained from simulated data to those obtained numerically by the DRBEM. Results are presented for neoplasms of Clark levels II–IV to demonstrate the feasibility of the proposed methodology.
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Magalhaes, C., J. Mendes, R. Valenca Filipe, and R. Vardasca. "Skin neoplasms dynamic thermal assessment." In 2019 IEEE 6th Portuguese Meeting on Bioengineering (ENBENG). IEEE, 2019. http://dx.doi.org/10.1109/enbeng.2019.8692482.

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Moryatov, A. A., S. V. Kozlov, O. I. Kaganov, A. E. Orlov, V. P. Zaharov, I. A. Batrachenko, D. N. Artemiev, and N. V. Blinov. "Raman spectroscopy of skin neoplasms." In PHYSICS OF CANCER: INTERDISCIPLINARY PROBLEMS AND CLINICAL APPLICATIONS: Proceedings of the International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17). Author(s), 2017. http://dx.doi.org/10.1063/1.5001630.

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Bratchenko, I. A., Yu A. Kristoforova, O. O. Myakinin, D. N. Artemyev, S. V. Kozlov, A. A. Moryatov, and V. P. Zakharov. "Fluorescence spectroscopy for neoplasms control." In SPIE Photonics Europe, edited by Jürgen Popp, Valery V. Tuchin, Dennis L. Matthews, and Francesco S. Pavone. SPIE, 2016. http://dx.doi.org/10.1117/12.2227610.

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Ageikina, M. A. "The use of splenectomy in the treatment of spleen neoplasia in rats." In SPbVetScience. FSBEI HE St. Petersburg SUVM, 2023. http://dx.doi.org/10.52419/3006-2023-8-4-6.

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To date, a significant percentage of surgical interventions account for abdominal operations in small pets. At the same time, the problem of the prevalence of neoplasms in decorative rats is relevant. Splenectomy is one of the most effective methods of treating neoplasia for them. It is recommended to undergo a medical examination every six months, since splenomegaly is noticed only when the organ is enlarged during a visual diagnostic examination.
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Stranadko, Eugeny P. "Clinical photodynamic therapy of malignant neoplasms." In Photodynamic Therapy of Cancer II. SPIE, 1995. http://dx.doi.org/10.1117/12.199150.

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Koh, JS, JS Jang, MK Joo, BJ Lee, JJ Park, HJ Chun, SW Lee, and YT Bak. "ENDOSCOPIC SUBMUCOSAL RESECTION FOR DUODENAL NEOPLASMS." In ESGE Days 2018 accepted abstracts. Georg Thieme Verlag KG, 2018. http://dx.doi.org/10.1055/s-0038-1637299.

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Malev, Carlo C. "Abstract IA15: Measuring evolution in neoplasms." In Abstracts: Second AACR International Conference on Frontiers in Basic Cancer Research--Sep 14-18, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.fbcr11-ia15.

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Reports on the topic "Neoplasms"

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Lifshitz, Guy, Rotem Franko, Nitzan Goldberg, Nili Gutwetter, Nayyera Tibi, Shmuel Avital, and Yaron Rudnicki. Can Conservative Management of Simple Acute Appendicitis Miss a Diagnosis of Appendiceal Neoplasms? A Histological Evaluation of 686 Appendectomies of Simple Appendicitis. International Journal of Surgery, June 2024. http://dx.doi.org/10.60122/j.ijs.2024.20.02.

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Background: Acute appendicitis is one of the most common surgical disease with an estimated lifetime risk of about 6-8%. Non-operative management of appendicitis is gaining popularity worldwide. Appendiceal tumors are rare and confirmed by histopathological examination in 0.5-2.5% of all appendectomies. The risk of missing an appendiceal tumor with a non-operative treatment is not well established. The aim of this study was to assess the incidence of appendiceal neoplasm in patients presented with simple non-perforated appendicitis. Materials and Methods: A retrospective study of all patients, that underwent an appendectomy from January 2018 to June 2020 in a single academic center. The histopathological reports were reviewed for appendiceal tumor. The patients’ and disease characteristics were recorded. Final analysis included only patients with simple acute appendicitis. Results: 686 patients that underwent an emergent appendectomy for a simple acute appendicitis, nine patients (1.41%) were found to have an appendiceal neoplasm on final pathology. The preoperative imaging study did not reveal any suspicious findings for appendiceal neoplasm. Neoplasms revealed by histopathological examination include three neuroendocrine tumor (NET), four low-grade mucinous neoplasm and two adenocarcinomas. The mean age for appendiceal NET was 25.33 ± 4.72, for mucinous neoplasm 48.75 ± 29.22 and 62 ± 12.72 for adenocarcinoma. Logistic regression demonstrated a significant difference in appendiceal diameter and white blood cell count between the neoplasm and acute appendicitis group. Conclusion: Although appendiceal neoplasm following an appendectomy for simple acute appendicitis is not common, it is a concern that need to be addressed. Despite the wide use of imaging study for the diagnosis, it does not provide diagnostic indication for the existence of an appendiceal neoplasm in our cases. The risk of an appendiceal neoplasm, albeit low, should be taken into consideration in the management of adult patients with acute appendicitis before a decision to embark on a non-operative therapy.
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2

Reuther, Gary W. Enhancing Targeted Therapy for Myeloproliferative Neoplasms. Fort Belvoir, VA: Defense Technical Information Center, December 2014. http://dx.doi.org/10.21236/ada613864.

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Reuther, Gary W. Enhancing Targeted Therapy for Myeloproliferative Neoplasms. Fort Belvoir, VA: Defense Technical Information Center, October 2013. http://dx.doi.org/10.21236/ada600492.

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Steven Larson MD. Cyclotron Produced Radionuclides for Diagnosis and Therapy of Human Neoplasms. Office of Scientific and Technical Information (OSTI), September 2009. http://dx.doi.org/10.2172/964282.

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Chen, Chuyan, Yi Yang, Peng Li, and Haiyi Hu. Incidence of gastric neoplasms arising from autoimmune metaplastic atrophic gastritis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0021.

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Tran, Emily, Jasmine J. Park, Nandini N. Kulkarni, and Vinay S. Gundlapalli. Left Facial Primary Leiomyosarcoma Misdiagnosed as Atypical Fibroxanthoma and Immunochemical Markers Relevant to Diagnosis: A Case Report. Science Repository, February 2024. http://dx.doi.org/10.31487/j.ajscr.2023.04.03.

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Soft tissue sarcomas are relatively rare neoplasms of mesenchymal origin that generally make up less than 2% of all adult malignant neoplasms. Atypical fibroxanthoma is a benign soft tissue tumor often confused with malignant variants of similar tumors such as leiomyosarcoma due to similar staining markers and cell morphology. We report a case of a 70-year-old caucasian male who initially presented with a 2 cm exophytic left facial lesion that was misdiagnosed as atypical fibroxanthoma upon biopsy. The patient underwent a wide local excision of the growing 11 cm mass and immediate reconstruction with a cervicofacial flap and full thickness skin graft. Pathological analysis of the specimen revealed the final diagnosis as confirmed primary leiomyosarcoma. Both the patient’s biopsy report and the surgical pathology report revealed similar negative findings (desmin, cytokeratin AE1/AE3, p63, SOX10) as well as similar positive findings (smooth muscle actin and CD68). Critical distinctions that led to a change in diagnosis from atypical fibroxanthoma to leiomyosarcoma emerged during the final pathological analysis, which revealed more widespread positive staining for smooth muscle actin and muscle-specific actin throughout the surgical specimen along with detailed cell and nucleus morphology of atypical spindle cells in the dermis and subcutis. This valuable information was not available during the initial biopsy when the lesion was smaller. It is possible that earlier diagnosis of primary leiomyosarcoma could have resulted in advanced pre-operative treatment and excision of the facial lesion, preventing involvement of surrounding areas such as the patient’s left eye, ear, and facial nerve.
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WEI, WEI. The prognostic factors and the optimal treatment of mixed neuroendocrine-non-neuroendocrine neoplasms(MiNEN) from digestive system. A meta-analysis and review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2022. http://dx.doi.org/10.37766/inplasy2022.4.0114.

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Ragunathan, Yoithapprabhunath Thuckanaickenpalayam, Srichinthu Kenniyan Kumar, Deepak Gupta, Diksha Singh, Swetha Pasupuleti, and Madhavan Nirmal Ramdas. Effectiveness of Neoadjuvant Molecular-Targeted Chemotherapy in Ameloblastoma - A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0018.

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Review question / Objective: The aim of this article is to obtain an in-depth review of ameloblastoma tumor to determine the available level of evidence and the possible benefit of targeted therapeutics for the treatment of BRAF V600E mutation in ameloblastoma tumor. Condition being studied: Ameloblastoma is an epithelium-derived odontogenic tumour that evolved since the prehistoric era. Ameloblastoma is unique among the odontogenic neoplasms occurring in the jaws, because of its locally invasive behaviour and high recurrence rate. Facial asymmetry, displacement of teeth, malocclusion, and pathologic fractures are some of the asymmetrical features that ameloblastoma is known to cause. If left untreated, they often lead to wide tissue destruction and deformity. For the treatment of ameloblastomas, conventional chemotherapy and radiation have been unexplored or contraindicated and to date, wide surgical resection is the only treatment of choice for ameloblastoma tumours, resulting in post-treatment compromised quality of life in the individuals.
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Bedi, Nishant, Nick Francis, Chris Bunker, and Michael Dinneen. Penile intraepithelial neoplasia. BJUI Knowledge, November 2022. http://dx.doi.org/10.18591/bjuik.0748.

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10

Савосько, Василь Миколайович, Юлія Бєлик, and Юрій Васильович Лихолат. Ecological and Geological Determination of the Initial Pedogenesis on Devastated Lands in the Kryvyi Rih Iron Mining & Metallurgical District (Ukraine). Journ. Geol. Geograph. Geoecology, 2019. http://dx.doi.org/10.31812/123456789/3643.

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In our time, a very urgent problem is the cessation of negative impacts on the environment and the return to the practical use of the territories of devastated lands. In this regard, it is important to find out the basic laws of primary soil formation in the area of these man-made neoplasms. The initial soil formation conditions were analyzed on 19 experimental sites which represent the main varieties of devastated land in the Kryvyi Rih Iron Mining and Metallurgical District (Central Ukraine): (i) waste rock dumps of old iron mines (old name “Forges”), (ii) tailing storage facility of underground iron mines, (iii) waste rock dumps of the Iron Ore Mining and Dressing Plant, (iv) waste rock dumps of the Granite Quarry Plant. It was established that on the devastated lands in Kryvyi Rih District, the initial soil formation occurs in very difficult conditions. Therefore, over 25- 100 years only very primitive soils were formed. The following features are inherent to them: (1) primitive soil profile (thickness 10-100 mm), (2) low levels of soil organic substance content (9.5-11.5 %), (3) alkaline indicators of the soil solution (pHH2O – 8.08-8.92, pHKCl – 7.42-8.23), (4) low levels of cation exchange capacity (6.34-8.47 mMol /100 g). By results of correlation calculations, among the factors of soil formation time (duration of soil formation) and input of plant ash elements’ fall are characterized by the maximum number of statistically significant correlation coefficients and their numerical values. In terms of chemical composition of the technosol, the values of organic matter content and exchangeable acidity (pHKCl) were the most predictable soil formation factors. Generally physical / chemical characteristics of geological rocks (as parent material) and time were the two most important factors in determining the initial pedogenesis on devastated lands in the Kryvyi Rih Iron Mining & Metallurgical District (Ukraine).
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