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Journal articles on the topic 'Negr1'

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Author: Grafiati

Published: 9 March 2023

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1

Kaare, Maria, Mohan Jayaram, Toomas Jagomäe, Katyayani Singh, Kalle Kilk, Kaie Mikheim, Marko Leevik, et al. "Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to Amphetamine in Male Mice." Brain Sciences 12, no. 12 (December 10, 2022): 1696. http://dx.doi.org/10.3390/brainsci12121696.

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In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1 (NEGR1) gene has been consistently linked with both depression and obesity. Although the linkage between NEGR1 and depression is the strongest, evidence also suggests the involvement of NEGR1 in a wide spectrum of psychiatric conditions. Here we show the expression of NEGR1 both in tyrosine- and tryptophan hydroxylase-positive cells. Negr1−/− mice show a time-dependent increase in behavioral sensitization to amphetamine associated with increased dopamine release in both the dorsal and ventral striatum. Upregulation of transcripts encoding dopamine and serotonin transporters and higher levels of several monoamines and their metabolites was evident in distinct brain areas of Negr1−/− mice. Chronic (23 days) escitalopram-induced reduction of serotonin and dopamine turnover is enhanced in Negr1−/− mice, and escitalopram rescued reduced weight of hippocampi in Negr1−/− mice. The current study is the first to show alterations in the brain monoaminergic systems in Negr1-deficient mice, suggesting that monoaminergic neural circuits contribute to both depressive and obesity-related phenotypes linked to the human NEGR1 gene.

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Kaare, Maria, Kaie Mikheim, Kersti Lilleväli, Kalle Kilk, Toomas Jagomäe, Este Leidmaa, Maria Piirsalu, et al. "High-Fat Diet Induces Pre-Diabetes and Distinct Sex-Specific Metabolic Alterations in Negr1-Deficient Mice." Biomedicines 9, no. 9 (September 3, 2021): 1148. http://dx.doi.org/10.3390/biomedicines9091148.

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In the large GWAS studies, NEGR1 gene has been one of the most significant gene loci for body mass phenotype. The purpose of the current study was to clarify the role of NEGR1 in the maintenance of systemic metabolism, including glucose homeostasis, by using both male and female Negr1−/− mice receiving a standard or high fat diet (HFD). We found that 6 weeks of HFD leads to higher levels of blood glucose in Negr1−/− mice. In the glucose tolerance test, HFD induced phenotype difference only in male mice; Negr1−/− male mice displayed altered glucose tolerance, accompanied with upregulation of circulatory branched-chain amino acids (BCAA). The general metabolomic profile indicates that Negr1−/− mice are biased towards glyconeogenesis, fatty acid synthesis, and higher protein catabolism, all of which are amplified by HFD. Negr1 deficiency appears to induce alterations in the efficiency of energy storage; reduced food intake could be an attempt to compensate for the metabolic challenge present in the Negr1−/− males, particularly during the HFD exposure. Our results suggest that the presence of functional Negr1 allows male mice to consume more HFD and prevents the development of glucose intolerance, liver steatosis, and excessive weight gain.

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Sim, Gyuri, Moonkyung Jeong, Hyunseok Seo, Jangrae Kim, and Soojin Lee. "The Role of N-Glycosylation in the Intracellular Trafficking and Functionality of Neuronal Growth Regulator 1." Cells 11, no. 7 (April 6, 2022): 1242. http://dx.doi.org/10.3390/cells11071242.

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Neuronal growth regulator 1 (NEGR1) is a brain-enriched membrane protein that is involved in neural cell communication and synapse formation. Accumulating evidence indicates that NEGR1 is a generic risk factor for various psychiatric diseases including autism and depression. Endoglycosidase digestion of single NEGR1 mutants revealed that the wild type NEGR1 has six putative N-glycosylation sites partly organized in a Golgi-dependent manner. To understand the role of each putative N-glycan residue, we generated a series of multi-site mutants (2MT–6MT) with additive mutations. Cell surface staining and biotinylation revealed that NEGR1 mutants 1MT to 4MT were localized on the cell surface at different levels, whereas 5MT and 6MT were retained in the endoplasmic reticulum to form highly stable multimer complexes. This indicated 5MT and 6MT are less likely to fold correctly. Furthermore, the removal of two N-terminal sites N75 and N155 was sufficient to completely abrogate membrane targeting. An in vivo binding assay using the soluble NEGR1 protein demonstrated that glycans N286, N294 and N307 on the C-terminal immunoglobulin-like domain play important roles in homophilic interactions. Taken together, these results suggest that the N-glycan moieties of NEGR1 are closely involved in the folding, trafficking, and homodimer formation of NEGR1 protein in a site-specific manner.

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Carboni, Lucia, Francesca Pischedda, Giovanni Piccoli, Mario Lauria, Laura Musazzi, Maurizio Popoli, Aleksander A. Mathé, and Enrico Domenici. "Depression-Associated Gene Negr1-Fgfr2 Pathway Is Altered by Antidepressant Treatment." Cells 9, no. 8 (July 31, 2020): 1818. http://dx.doi.org/10.3390/cells9081818.

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The Negr1 gene has been significantly associated with major depression in genetic studies. Negr1 encodes for a cell adhesion molecule cleaved by the protease Adam10, thus activating Fgfr2 and promoting neuronal spine plasticity. We investigated whether antidepressants modulate the expression of genes belonging to Negr1-Fgfr2 pathway in Flinders sensitive line (FSL) rats, in a corticosterone-treated mouse model of depression, and in mouse primary neurons. Negr1 and Adam10 were the genes mostly affected by antidepressant treatment, and in opposite directions. Negr1 was down-regulated by escitalopram in the hypothalamus of FSL rats, by fluoxetine in the hippocampal dentate gyrus of corticosterone-treated mice, and by nortriptyline in hippocampal primary neurons. Adam10 mRNA was increased by nortriptyline administration in the hypothalamus, by escitalopram in the hippocampus of FSL rats, and by fluoxetine in mouse dorsal dentate gyrus. Similarly, nortriptyline increased Adam10 expression in hippocampal cultures. Fgfr2 expression was increased by nortriptyline in the hypothalamus of FSL rats and in hippocampal neurons. Lsamp, another IgLON family protein, increased in mouse dentate gyrus after fluoxetine treatment. These findings suggest that Negr1-Fgfr2 pathway plays a role in the modulation of synaptic plasticity induced by antidepressant treatment to promote therapeutic efficacy by rearranging connectivity in corticolimbic circuits impaired in depression.

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5

Wang, Zheng, Jianguang Liu, Qiuxiang Yang, and Mengjie Ma. "LncRNA MIAT Upregulates NEGR1 by Competing for miR-150-5p as a Competitive Endogenous RNA in SCIRI Rats." International Journal of Genomics 2022 (December 28, 2022): 1–13. http://dx.doi.org/10.1155/2022/2942633.

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Objective. Spinal cord ischemia–reperfusion injury (SCIRI) can cause a pathological state of irreversible delayed death of neurons in the spinal cord tissue and a range of complications, such as spinal cord dysfunction and motor function impairment. This study aimed to determine whether the long-stranded non-coding ribonucleic acid (lncRNA), myocardial infarction-associated transcript (MIAT), could upregulate neuronal growth regulator 1 (NEGR1) by competing for miR-150-5p as a competitive endogenous RNA in a rat SCIRI model. Methods. The MIAT knockdown vector or the corresponding blank vector was injected into the spinal cord of healthy sprague Dawley (SD) rats. Administration of the MIAT knockdown vector led to the establishment of the SCIRI rat model. Basso, Beattie & Bresnahan locomotor rating scale (BBB) assessment of hind limb motion. Pathological changes in the spinal cord were observed via hematoxylin and eosin staining and eosin staining. Quantitative polymerase chain reaction was performed to determine the expression levels of the candidate microRNAs and predicted candidate genes, and the relationship between them. Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL) staining was used to detect apoptosis in the spinal cord tissue of rats in each group. Western blotting was performed to determine the expression of the apoptosis-related proteins, caspase-9, caspase-3, and BCL2-Associated X (Bax)/B-cell lymphoma-2 (Bcl-2). The luciferase reporter gene was used to assess the interaction among the lncRNA, MIAT, and miR-150-5, and the interaction between miR-150-5 and NEGR1. Results. The sh-lncRNA, MIAT, improved exercise status, and pathological changes in the spinal cord of SCIRI rats, inhibited apoptosis, increased the expression of miR-150-5p, and reduced the expression of NEGR1. Compared with mimics-NC, the transfection of miR-150-5p significantly decreased the relative fluorescence activity ratio of MIAT 3′-untranslated region (3′-UTR) wild-type Human embryonic kidney cells 293 (HEK-293 cells). Compared with mimics-negative control (NC), the transfection of miR-150-5p significantly decreased the relative fluorescence activity ratio of NEGR1 3′-UTR wild-type HEK-293 cells. Conclusion. MIAT can affect the symptoms of SCIRI in rats. Furthermore, as a competitive endogenous RNA, MIAT upregulates NEGR1 by competing with miR-150-5p in SCIRI rats.

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6

Noh, Kyungchul, Hyunkyoung Lee, Tae-Yong Choi, Yeonhee Joo, Soo-Joeng Kim, Hyejin Kim, Jin Young Kim, et al. "Negr1 controls adult hippocampal neurogenesis and affective behaviors." Molecular Psychiatry 24, no. 8 (January 16, 2019): 1189–205. http://dx.doi.org/10.1038/s41380-018-0347-3.

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Noh, Kyungchul, Hyunkyoung Lee, Tae-Yong Choi, Yeonhee Joo, Soo-Joeng Kim, Hyejin Kim, Jin Young Kim, et al. "Negr1 controls adult hippocampal neurogenesis and affective behaviors." IBRO Reports 6 (September 2019): S241. http://dx.doi.org/10.1016/j.ibror.2019.07.753.

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8

Tassano, Elisa, Sara Uccella, Thea Giacomini, Patrizia Fiorio, Elisa Tavella, Michela Malacarne, Giorgio Gimelli, Domenico Coviello, and Patrizia Ronchetto. "1p31.1 microdeletion including only NEGR1 gene in two patients." European Journal of Medical Genetics 63, no. 6 (June 2020): 103919. http://dx.doi.org/10.1016/j.ejmg.2020.103919.

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9

Mikheim, K., K. Singh, M. Jayaram, M. Kaare, M. A. Philips, and E. Vasar. "Depression-associated behavioural changes in NEGR1 gene deficient mice." Neuroscience Applied 1 (2022): 100205. http://dx.doi.org/10.1016/j.nsa.2022.100205.

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10

An, Dayoung, Yeonhee Joo, and Hyejin Kim. "The role of NEGR1 in the formation of lipid droplets." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.09960.

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11

Philips, M. A., M. Kaare, M. Kaie, J. Mohan, and S. Katyayani. "Pleiotropic impact of Negr1 on the psychiatric disorders and obesity." Neuroscience Applied 1 (2022): 100944. http://dx.doi.org/10.1016/j.nsa.2022.100944.

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12

Jagomäe, Toomas, Katyayani Singh, Mari-Anne Philips, Mohan Jayaram, Kadri Seppa, Triin Tekko, Scott F. Gilbert, Eero Vasar, and Kersti Lilleväli. "Alternative Promoter Use Governs the Expression of IgLON Cell Adhesion Molecules in Histogenetic Fields of the Embryonic Mouse Brain." International Journal of Molecular Sciences 22, no. 13 (June 28, 2021): 6955. http://dx.doi.org/10.3390/ijms22136955.

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The members of the IgLON superfamily of cell adhesion molecules facilitate fundamental cellular communication during brain development, maintain functional brain circuitry, and are associated with several neuropsychiatric disorders such as depression, autism, schizophrenia, and intellectual disabilities. Usage of alternative promoter-specific 1a and 1b mRNA isoforms in Lsamp, Opcml, Ntm, and the single promoter of Negr1 in the mouse and human brain has been previously described. To determine the precise spatiotemporal expression dynamics of Lsamp, Opcml, Ntm isoforms, and Negr1, in the developing brain, we generated isoform-specific RNA probes and carried out in situ hybridization in the developing (embryonic, E10.5, E11.5, 13.5, 17; postnatal, P0) and adult mouse brains. We show that promoter-specific expression of IgLONs is established early during pallial development (at E10.5), where it remains throughout its differentiation through adulthood. In the diencephalon, midbrain, and hindbrain, strong expression patterns are initiated a few days later and begin fading after birth, being only faintly expressed during adulthood. Thus, the expression of specific IgLONs in the developing brain may provide the means for regionally specific functionality as well as for specific regional vulnerabilities. The current study will therefore improve the understanding of how IgLON genes are implicated in the development of neuropsychiatric disorders.

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13

Brugger, Steven W., M. Cannon Gardner, Jeremy T. Beales, Farren Briggs, and Mary F. Davis. "Depression in multiple sclerosis patients associated with risk variant near NEGR1." Multiple Sclerosis and Related Disorders 46 (November 2020): 102537. http://dx.doi.org/10.1016/j.msard.2020.102537.

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14

YOO, ARA. "NEGR1 may associate with a cluster of differentiation 36 (CD36) protein." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.09905.

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15

Takita, Junko, Yuyan Chen, Jun Okubo, Masashi Sanada, Masatoki Adachi, Kentaro Ohki, Riki Nishimura, et al. "Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma." Cancer Science 102, no. 9 (July 3, 2011): 1645–50. http://dx.doi.org/10.1111/j.1349-7006.2011.01995.x.

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16

Kim, Hyejin, Ji-Sook Hwang, Bogman Lee, Jinpyo Hong, and Soojin Lee. "Newly Identified Cancer-Associated Role of Human Neuronal Growth Regulator 1 (NEGR1)." Journal of Cancer 5, no. 7 (2014): 598–608. http://dx.doi.org/10.7150/jca.8052.

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17

Dennis, Emily L., Neda Jahanshad, Meredith N. Braskie, Nicholus M. Warstadt, Derrek P. Hibar, Omid Kohannim, Talia M. Nir, et al. "Obesity gene NEGR1 associated with white matter integrity in healthy young adults." NeuroImage 102 (November 2014): 548–57. http://dx.doi.org/10.1016/j.neuroimage.2014.07.041.

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18

Luo, Haifeng. "Association between CNVs of BMI-related gene and survival status of LUAD and LUSC patients." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e20524-e20524. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e20524.

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e20524 Background: In recent decades, many GWAS studies help to discover the gene related to BMI or obesity. FTO, BDNF, LEPR, MC4R, SH2B1, GNPDA2, INSIG2, KCTD15, LEP, MTCH2, NEGR1, NPC1, PCSK1, POMC, TMEM18 and UCP2 are 16 genes showing most significant association with BMI. Those genes impact BMI by either alternating sex hormone metabolism, influencing insulin and insulin-like growth factor, or mediating inflammatory and adipokines. Those pathways impact cancer cells also. Here we report the association between copy number variables (CNV) of those genes and outcome of lung adenocarcinoma (LUAD) and lung squamous cell cancer (LUSC). Methods: 522 individuals in LUAD dataset of TCGA and 504 individuals in LUSC dataset of TCGA are included in this study. CNVs of each gene are main predictors, the survival time is the main outcome in the study, and gender, tumor stage, smoking status are chosen to adjust model. Multivariable Cox models are generated for LUAD patients and LUSC patients respectively. To control false discovery rate (FDR), Benjamini-Hochberg procedure is employed. Results: For LUAD patients, tumor stages impact survival status significantly, but age, gender and smoking status don’t impact survival time significantly. At the same time, CNV of TMEM18 has hazard ratio of 0.0353 (95% CI: 0.0032, 0.3910), which means the gain of genetic materials on the position of TMEM18 gene will protect patients to die after diagnosis of LUAD, and the effect is extremely large. The p-value of 0.006 is less than 0.00625, which is derived with Benjamini-Hochberg procedure with false discovery rate of 0.1. For LUSC patients, only serious tumor stages, tumor stage III and tumor stage IV, impact survival status significantly, and old age will cause patients die earlier significantly. Neither gender nor smoking status don’t impact survival status significantly. When adjusting age, gender, smoking status, and tumor stage, gain of genetic materials on the position of NEGR1 gene does increase the risk of death significantly, and the hazard ratio of CNV of NEGR1 is 9.920 (95% CI: 1.237, 79.552). The p-value of 0.031 is large than 0.00625, which is derived with Benjamini-Hochberg procedure with fase discovery rate of 0.1. Conclusion: Copy number variable of TMEM18 gene impact outcome of LUAD patients significantly. The gain of TMEM18 genetic materials protects patients to die, meanwhile the loss of TMEM18 genetic materials cause patients to have shorter overall survival time. TMEM18 affect the central nervous system to imbalance energy metabolism in previous murine models, and here we found TMEM18 has significant impact on survival status of LUAD patients, so the transmembrane protein gene TMEM18 may be a key factor to outcome of LUAD.

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Gamero-Villarroel, C., L. María González, I. Gordillo, J. Antonio Carrillo, A. García-Herráiz, I. Flores, R. Rodríguez-López, and G. Gervasini. "Impact of NEGR1 genetic variability on psychological traits of patients with eating disorders." Pharmacogenomics Journal 15, no. 3 (September 23, 2014): 278–83. http://dx.doi.org/10.1038/tpj.2014.53.

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Noh, Kyungchul, Hyunkyoung Lee, Tae-Yong Choi, Yeonhee Joo, Soo-Joeng Kim, Hyejin Kim, Jin Young Kim, et al. "Negr1 regulates hippocampal Lcn2 expression and affective behaviour via interaction with LIF receptor." Molecular Psychiatry 24, no. 8 (July 23, 2019): 1095. http://dx.doi.org/10.1038/s41380-019-0455-8.

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Rana, Sobia, and Maha Mobin. "Association of the NEGR1 rs2815752 with obesity and related traits in Pakistani females." Upsala Journal of Medical Sciences 125, no. 3 (May 18, 2020): 226–34. http://dx.doi.org/10.1080/03009734.2020.1756996.

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22

Boender, Arjen J., Margriet A. van Gestel, Keith M. Garner, Mieneke C. M. Luijendijk, and Roger A. H. Adan. "The obesity-associated gene Negr1 regulates aspects of energy balance in rat hypothalamic areas." Physiological Reports 2, no. 7 (July 2014): e12083. http://dx.doi.org/10.14814/phy2.12083.

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23

Breton, E., V. Gagné-Ouellet, K. Thibeault, R. Guérin, Rj Van Lieshout, P. Perron, Mf Hivert, and L. Bouchard. "Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children." Epigenetics 15, no. 3 (September 23, 2019): 323–35. http://dx.doi.org/10.1080/15592294.2019.1666653.

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24

Park, Keebum, Kyungchul Noh, and Sung Joong Lee. "Negr1 KO mice show socially submissive phenotype when co-housed with wild-type mice." IBRO Reports 6 (September 2019): S442. http://dx.doi.org/10.1016/j.ibror.2019.07.1400.

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25

Tassano, Elisa, Alessandra Gamucci, Maria E. Celle, Patrizia Ronchetto, Cristina Cuoco, and Giorgio Gimelli. "Clinical and Molecular Cytogenetic Characterization of a de novo Interstitial 1p31.1p31.3 Deletion in a Boy with Moderate Intellectual Disability and Severe Language Impairment." Cytogenetic and Genome Research 146, no. 1 (2015): 39–43. http://dx.doi.org/10.1159/000431391.

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Interstitial 1p deletions are rare events. Very few cases of 1p31.1p31.3 deletions characterized by variable phenotypes have been reported. No clear genotype-phenotype correlation has been determined yet. We present a child with a de novo interstitial 1p31.1p31.3 deletion, identified by array CGH, associated with intellectual disability and severe language impairment. The deleted region contains 20 OMIM genes, but we focused on GADD45A (MIM 126335; growth arrest- and DNA damage-inducible gene), LRRC7 (MIM 614453; leucine-rich repeat-containing protein 7), and NEGR1 (MIM 613173; neuronal growth regulator 1). We discuss whether these genes play a role in determining the phenotype of our patient in order to investigate the possibility of a genotype-phenotype correlation.

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Boender, Arjen J., Andrea J. Van Rozen, and Roger A. H. Adan. "Nutritional State Affects the Expression of the Obesity-Associated Genes Etv5, Faim2, Fto , and Negr1." Obesity 20, no. 12 (December 2012): 2420–25. http://dx.doi.org/10.1038/oby.2012.128.

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Pischedda, Francesca, Joanna Szczurkowska, Maria Daniela Cirnaru, Florian Giesert, Elena Vezzoli, Marius Ueffing, Carlo Sala, et al. "A Cell Surface Biotinylation Assay to Reveal Membrane-associated Neuronal Cues: Negr1 Regulates Dendritic Arborization." Molecular & Cellular Proteomics 13, no. 3 (December 31, 2013): 733–48. http://dx.doi.org/10.1074/mcp.m113.031716.

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Cheon, Yeongmi, Ara Yoo, Hyunseok Seo, Seo-Young Yun, Hyeonhee Lee, Heeji Lim, Youngho Kim, Lihua Che, and Soojin Lee. "Na/K-ATPase beta1-subunit associates with neuronal growth regulator 1 (NEGR1) to participate in intercellular interactions." BMB Reports 54, no. 3 (March 31, 2021): 164–69. http://dx.doi.org/10.5483/bmbrep.2021.54.3.116.

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Vieira de Melo Gomes Oliveira, Albertina. "A MÁSCARA DO SILÊNCIO: de Anastácia a Kilomba, as mulheres negras romperam a máscara." Aturá - Revista Pan-Amazônica de Comunicação 4, no. 2 (May 1, 2020): 150–73. http://dx.doi.org/10.20873/uft.2526-8031.2020v4n2p150.

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O presente estudo, apresenta uma breve revisão sobre período da escravatura, do movimento negro feminista e uma análise acerca de como a mulher negra é representada no editorial de gênero do jornal The New York Times, o In Her Words. O objetivo foi apontar como a teoria do matriarcado negro poderia ter atrapalhado ainda mais a mulher negra na luta pelos seus direitos, o movimento feminista negro e entender de que forma o editorial de gênero do jornal The New York Times trabalha a representatividade da mulher negra na mídia. A análise do editorial de gênero apontou que apesar de ter representatividade na mídia, o espaço reservado à mulher negra ainda é reduzido.

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Araujo, Valmir Teixeira, and Cicilia Maria Krohling Peruzzo. "Imprensa negra e cidadania: conteúdos do Correio Nagô, Mundo Negro e Nação Z." MATRIZes 15, no. 2 (August 31, 2021): 229–50. http://dx.doi.org/10.11606/issn.1982-8160.v15i2p229-250.

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Este artigo discute a produção da imprensa negra no Brasil, do ponto de vista histórico e conceitual, dialogando com conceitos de cidadania e cidadania negra. Para tanto, apresenta-se um breve histórico da resistência negra, destacando a imprensa negra e os resultados de uma análise de conteúdo dos sites jornalísticos negros Nação Z, Mundo Negro e Correio Nagô, visando averiguar suas tendências temáticas e contribuições à ampliação da cidadania negra. As análises indicam uma importante contribuição da imprensa negra para a publicização de análises críticas sobre a situação do negro no Brasil, suas conquistas e direitos, bem como a priorização dessas temáticas favoráveis à igualdade social na busca pela ampliação da cidadania da população negra.

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Kaur, Prameet, Jun Rong Tan, Dwi Setyowati Karolina, Sugunavathi Sepramaniam, Arunmozhiarasi Armugam, Tsun-Hon Peter Wong, and Kandiah Jeyaseelan. "Supporting data for characterization of non-coding RNAs associated with the Neuronal growth regulator 1 (NEGR1) adhesion protein." Data in Brief 7 (June 2016): 381–85. http://dx.doi.org/10.1016/j.dib.2016.02.053.

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Taborda Moreira, Terezinha. "poética do inacabamento." Aletria: Revista de Estudos de Literatura 30, no. 2 (May 15, 2020): 39–58. http://dx.doi.org/10.35699/2317-2096.2020.21939.

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O artigo analisa a obra Negrices em flor, da poeta, compositora e atriz negra Maria Tereza, explorando como a escrita poética da autora expõe a invisibilidade, o silenciamento e a subalternização de sujeitos produzidos no encontro e na violência colonial. Atenta à dupla subalternização da mulher negra, a escrita assume um discurso que se volta não apenas para o corpo negro, mas, mais especificamente, para o corpo feminino negro. Desse lugar de fala a escrita se constrói como testemunho de uma memória negra, enquanto ressignificar a diáspora como ato gerador de um “corposolo” também negro. Esse corposolo negro, contrariando a colonialidade do poder, afirma-se como um “pensamento crítico de fronteira” por meio do qual a voz lírica redefine as ideias de cidadania, democracia, direitos humanos e humanidade, conforme impostas pela modernidade europeia, para permitir ao sujeito negro, especialmente o feminino, ancorar sua existência em outras cosmologias e outras epistemologias.

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Taborda Moreira, Terezinha. "poética do inacabamento." Aletria: Revista de Estudos de Literatura 30, no. 2 (May 15, 2020): 39–58. http://dx.doi.org/10.35699/2317-2096.2020.21939.

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O artigo analisa a obra Negrices em flor, da poeta, compositora e atriz negra Maria Tereza, explorando como a escrita poética da autora expõe a invisibilidade, o silenciamento e a subalternização de sujeitos produzidos no encontro e na violência colonial. Atenta à dupla subalternização da mulher negra, a escrita assume um discurso que se volta não apenas para o corpo negro, mas, mais especificamente, para o corpo feminino negro. Desse lugar de fala a escrita se constrói como testemunho de uma memória negra, enquanto ressignificar a diáspora como ato gerador de um “corposolo” também negro. Esse corposolo negro, contrariando a colonialidade do poder, afirma-se como um “pensamento crítico de fronteira” por meio do qual a voz lírica redefine as ideias de cidadania, democracia, direitos humanos e humanidade, conforme impostas pela modernidade europeia, para permitir ao sujeito negro, especialmente o feminino, ancorar sua existência em outras cosmologias e outras epistemologias.

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Oliveira, Fábio Nogueira de. "Modernidade, política e práxis negra no pensamento de Clóvis Moura." Plural (São Paulo. Online) 18, no. 1 (June 8, 2011): 45. http://dx.doi.org/10.11606/issn.2176-8099.pcso.2011.74521.

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<p>O pensamento de Clóvis Moura (1925-2003) contribuiu, de forma crítica, à reconstrução simbólica do negro como sujeito político em torno da práxis negra e da defesa de uma sociologia do negro, antiacadêmica (construída fora da sociologia produzida pelas instituições universitárias e em oposição a ela) e militante. Em seus escritos dos anos 1970 e 1980, como fenômeno sociopolítico, a práxis negra se inscreve como parte da modernidade e da conflituosa integração do negro na sociedade ocidental e como categoria-chave na tradução do marxismo a partir da perspectiva do negro.</p>

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Raghavan, Neha S., Badri Vardarajan, and Richard Mayeux. "Genomic variation in educational attainment modifies Alzheimer disease risk." Neurology Genetics 5, no. 2 (February 11, 2019): e310. http://dx.doi.org/10.1212/nxg.0000000000000310.

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ObjectiveTo determine the putative protective relationship of educational attainment on Alzheimer disease (AD) risk using Mendelian randomization and to test the hypothesis that by using genetic regions surrounding individually associated single nucleotide polymorphisms (SNPs) as the instrumental variable, we can identify genes that contribute to the relationship.MethodsWe performed Mendelian randomization using genome-wide association study summary statistics from studies of educational attainment and AD in two stages. Our instrumental variable comprised (1) 1,271 SNPs significantly associated with educational attainment and (2) individual 2-Mb regions surrounding the genome-wide significant SNPs.ResultsA causal inverse relationship between educational attainment and AD was identified by the 1,271 SNPs (odds ratio = 0.63; 95% confidence interval, 0.54–0.74; p = 4.08 x 10−8). Analysis of individual loci identified 2 regions that significantly replicated the causal relationship. Genes within these regions included LRRC2, SSBP2, and NEGR1; the latter a regulator of neuronal growth.ConclusionsEducational attainment is an important protective factor for AD. Genomic regions that significantly paralleled the overall causal relationship contain genes expressed in neurons or involved in the regulation of neuronal development.

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Antúnez-Ortiz, Diana Lizzete, Eugenia Flores-Alfaro, Ana Isabel Burguete-García, Amélie Bonnefond, Jesús Peralta-Romero, Philippe Froguel, Mónica Espinoza-Rojo, and Miguel Cruz. "Copy Number Variations in Candidate Genes and Intergenic Regions Affect Body Mass Index and Abdominal Obesity in Mexican Children." BioMed Research International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2432957.

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Introduction. Increase in body weight is a gradual process that usually begins in childhood and in adolescence as a result of multiple interactions among environmental and genetic factors. This study aimed to analyze the relationship between copy number variants (CNVs) in five genes and four intergenic regions with obesity in Mexican children.Methods. We studied 1423 children aged 6–12 years. Anthropometric measurements and blood levels of biochemical parameters were obtained. Identification of CNVs was performed by real-time PCR. The effect of CNVs on obesity or body composition was assessed using regression models adjusted for age, gender, and family history of obesity.Results. Gains in copy numbers ofLEPRandNEGR1were associated with decreased body mass index (BMI), waist circumference (WC), and risk of abdominal obesity, whereas gain inARHGEF4andCPXCR1and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d and losses inINSwere associated with increased BMI and WC.Conclusion. Our results indicate a possible contribution of CNVs inLEPR,NEGR1,ARHGEF4, andCPXCR1and the intergenic regions 12q15c, 15q21.1a, and 22q11.21d to the development of obesity, particularly abdominal obesity in Mexican children.

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Jiménez-Osorio, Angélica Saraí, Alma Olivia Aguilar-Lucio, Helios Cárdenas-Hernández, Claudette Musalem-Younes, Jacqueline Solares-Tlapechco, Paula Costa-Urrutia, Oscar Medina-Contreras, Julio Granados, and Martha Eunice Rodríguez-Arellano. "Polymorphisms in Adipokines in Mexican Children with Obesity." International Journal of Endocrinology 2019 (July 1, 2019): 1–5. http://dx.doi.org/10.1155/2019/4764751.

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The high prevalence of childhood obesity in Mexico is alarming in the health-science field. We propose to investigate the contribution of adipokines and cytokines polymorphisms and common BMI/obesity-associated loci, revealed in genome-wide association studies in Caucasian adult cohorts, with childhood obesity. This study included 773 Mexican-Mestizo children (5-15 years old) in a case-control study. The polymorphisms included were ADIPOQ (rs6444174), TNF-α (rs1800750), IL-1β (rs1143643), IL-6 (rs1524107; rs2069845), NEGR1 (rs34305371), SEC16B-RASAL2 (rs10913469), TMEM18 (rs6548238; rs7561317), GNPDA2 (rs16857402), LEP (rs2167270), MTCH2 (rs10838738), LGR4-LIN7C-BDNF (rs925946), BCDIN3D-FAIM2 (rs7138803), FTO (rs62033400), MC4R (rs11872992), MC4R (rs17782313), and KCTD15 (rs29942). No significant contribution was found with adipokines and cytokines polymorphisms in this study. Only both TMEM18 (rs6548238; rs7561317) polymorphisms were found associated with obesity (OR=0.5, P=0.008) and were in linkage disequilibrium (r2=0.87). The linear regression showed that the rs7561317 polymorphism of TMEM18 is negatively associated with obesity. This report highlights the influence of TMEM18 in Mexican-Mestizo children obesity, while adipokine and cytokine polymorphisms were not associated with it.

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Dong, Yuwei, Xiaoxuan Fan, Zhe Wang, Ling Zhang, and Shiwen Guo. "Circ_HECW2 functions as a miR-30e-5p sponge to regulate LPS-induced endothelial-mesenchymal transition by mediating NEGR1 expression." Brain Research 1748 (December 2020): 147114. http://dx.doi.org/10.1016/j.brainres.2020.147114.

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Kaare, M., M. Jayaram, T. Jagomäe, K. Singh, K. Kilk, M. Leevik, J. Varul, et al. "Depression-associated Negr1 gene-deficiency induces alterations in the monoaminergic neurotransmission enhancing time-dependent sensitization to amphetamine in mice." Neuroscience Applied 1 (2022): 100646. http://dx.doi.org/10.1016/j.nsa.2022.100646.

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Melo, Clarissa Damasceno. "Violência, criminalização e genocídio em Capão Pecado." Revista Crioula, no. 23 (August 3, 2019): 279–300. http://dx.doi.org/10.11606/issn.1981-7169.crioula.2019.156293.

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No presente trabalho, analisamos o romance Capão Pecado (2000), de Ferréz, pontuando a representação que faz do negro e sua inscrição em romances que (re) pensam a favela e seus problemas, dentre eles, a política de drogas. Para tal, em um primeiro momento, abordaremos as distinções entre a literatura sobre o negro e a literatura do negro, no contexto nacional de apagamento da cultura negra e marginalização da periferia, trazendo para o centro do debate o processo de atualização do discurso colonizador de domínio e genocídio da população pobre e negra. Posteriormente, discutimos as implicações entre discurso jurídico e controle social, por meio das quais institucionaliza-se a seletividade punitiva e o genocídio da juventude pobre e negra, passando à análise propriamente do romance. Como conclusão, entende-se que essa obra literária permite afirmar que a guerra às drogas tem se traduzido em uma guerra aos pobres e, ao longo dos anos, transformou-se em genocídio negro.

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Santiago Júnior, Francisco das Chagas Fernandes. "Imagem, raça e humilhação no espelho negro da nação: cultura visual, política e "pensamento negro" brasileiro durante a ditadura militar." Topoi (Rio de Janeiro) 13, no. 24 (June 2012): 94–110. http://dx.doi.org/10.1590/2237-101x013024007.

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Este artigo problematiza as relações entre cultura visual, "racialização" e novas sensibilidades políticas no Brasil de meados dos anos 1970 e princípios dos 1980 a partir das discussões da imagem e da representação do negro no cinema brasileiro. Observamos algumas das características da atualização e modificação da noção de raça no Brasil a partir da discussão sobre filmes brasileiros pelos representantes do que chamamos no texto de "pensamento negro", uma tradição reflexiva em formação que questionou como a intelectualidade brasileira concebia a cultura negra. A reflexão negra se apresenta num conjunto de escritos na imprensa nos quais desenvolveram uma retórica da imagem do negro como retórica de humilhação racial. A denúncia da humilhação negra na imagem produzida pelos brancos permitiu a constituição de uma nova identidade racial no Brasil.

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Santos Martins, Carlos Henrique, and Heloise Costa Silva. "Juventude negra e práticas escolares: anotações para uma perspectiva não homogeneizante do jovem negro." Argumentum 12, no. 1 (April 29, 2020): 50–66. http://dx.doi.org/10.18315/argumentum.v12i1.27815.

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O artigo traz a identidade negra não-homogeneizante como ponto crucial para debates sobre relações étnico-raciais, principalmente nas instituições escolares. Propõe a reflexão a respeito da construção de identidade de alunos negros em uma perspectiva que observe suas singularidades. Partindo da Lei 10.639/03, problematiza estruturas educacionais que reforçam o racismo, além de reafirmarem a ideia de uma identidade negra positivada, sem atentar para a seguinte discussão: que identidade negra é essa? Partindo de revisão bibliográfica e baseando-nos em Hall (2003), sugerimos pensar na ingênua noção que essencializa o negro, como se existisse um ser negro que reunisse todas as características necessárias para ser classificado como tal. São abordados conceitos acerca de identidade e juventude, visando estabelecer a relação entre eles, quando vinculados ao jovem negro em ambiente escolar.

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Motta Zamalloa, Edmundo. "UNA MANO DE NEGRO." Ciencia & Desarrollo, no. 3 (April 12, 2019): 115–21. http://dx.doi.org/10.33326/26176033.1996.3.74.

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El negro no es sólo el color de un rostro, es también un estereotipo social y ético, el personaje engreído del humor y la caricatura, tan familiar en la literatura grotesca y de la otra. Ha sido preferido como referente del honor, acaso porque el negro se asocia a la oscuridad ya las tinieblas. Muchas veces el negro fue tomado como el equivalente del mal, o quien mejor personifica al esclavo. La acción oculta, la maniobra indeseada que se consuma en un hecho es automáticamente atribuida a una mano negra, aunque sean blancos, claro está, los protagonistas de la intriga. El rito o la magia orientados a causar daño acaban asociándose al negro. La noche es negra, la muerte también.

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Szentkereszty-Kovács, Zita, Szilvia Fiatal, Eszter Anna Janka, Dóra Kovács, Andrea Szegedi, Éva Remenyik, and Dániel Törőcsik. "Leptin Receptor (rs1137101) and Brain-Derived Neurotrophic Factor (rs925946) Gene Variants Are Associated with Obesity in the Early- but Not in the Late-Onset Population of Hungarian Psoriatic Patients." Life 11, no. 10 (October 14, 2021): 1086. http://dx.doi.org/10.3390/life11101086.

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Background: Psoriatic patients have considerably higher odds of being obese compared with the general population; however, the exact pathophysiological link between psoriasis and obesity needs to be elucidated. Methods: To investigate the association of psoriasis with established obesity-related gene variants, we conducted a population-based case-control study including 3541 subjects (574 psoriasis cases and 2967 controls from the general Hungarian population). Genotyping of 20 SNPs at ADIPOQ, BDNF, FTO, GNPDA2, LEPR, MC4R, NEGR1, NPY, PPARG, TMEM18, and UCP2 were determined, and differences in genotype and allele distributions were investigated. Multiple logistic regression analyses were implemented. Results: Analysis revealed an association between the G allele of the rs1137101 polymorphism (LEPR gene) and obesity risk (OR: 3.30 (1.45; 7.50), p = 0.004) in the early-onset group of psoriatic patients. Furthermore, the T allele of rs925946 polymorphism (BDNF gene) was also associated with increased risk of obesity in early-onset psoriasis (OR: 2.26 (1.24; 4.14), p = 0.008). Conclusions: Our results suggest that in psoriatic patients, there are prominent differences in the causes of obesity that should be accounted for, including not only environmental factors but also patient characteristics, such as the time of disease onset as well as genetic factors.

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Lourenço, Kleber. "vozes que geram a forma no teatro negro feminista da Capulanas Cia. de Artes Negra." Arte da Cena (Art on Stage) 7, no. 2 (March 26, 2022): 196–220. http://dx.doi.org/10.5216/ac.v7i2.70393.

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O objetivo deste artigo é relatar uma experiência de militância feminista negra por meio da poética artística. Acompanharemos a trajetória da Capulanas Cia de Arte de Negra, grupo teatral de mulheres negras periféricas da zona sul da cidade de São Paulo e o seu trabalho estético que contribui para a produção de novas epistemes. Aqui, um cruzamento de vozes apresenta perspectivas sobre o trabalho da companhia, seus processos criativos e a recepção do público com uma de suas obras. Com isso, refletimos sobre o pensamento estético de um teatro negro que abrange temas sociais e políticos. Palavras-chave: Teatro Negro. Feminismo Negro. Artetnografia. Corpo Motriz.

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Poveda, Alaitz, María Eugenia Ibáñez, and Esther Rebato. "Common variants in BDNF, FAIM2, FTO, MC4R, NEGR1, and SH2B1 show association with obesity-related variables in Spanish Roma population." American Journal of Human Biology 26, no. 5 (June 20, 2014): 660–69. http://dx.doi.org/10.1002/ajhb.22576.

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Kaare, M., A. Bregin, K. Singh, M. Yayaram, J. Innos, M. A. Philips, and E. Vasar. "P.716 Negr1-deficient mice display anxiolytic effect in the open field but their sensitivity to amphetamine is not altered." European Neuropsychopharmacology 29 (December 2019): S484. http://dx.doi.org/10.1016/j.euroneuro.2019.09.757.

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Oliveira, Luciana de, Ester Antonieta Santos, Frederico Mendes de Carvalho, and Washington Luís Santos Oliveira. "Lutas por autodefinição de subjetividades negras em contextos organizacionais: racismo, autoimagem e resistências afrodiaspóricas." Organicom 18, no. 36 (September 21, 2021): 225–37. http://dx.doi.org/10.11606/issn.2238-2593.organicom.2021.185062.

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Neste artigo, discutimos algumas tensões entre modulações discursivas antirracistas em contextos organizacionais em face a episódios de racismo e ações individuais de trabalhadores e trabalhadoras para denunciá-los e repará-los judicialmente. Metodologicamente, analisamos sete casos que tiveram visibilidade midiática a partir de busca no acervo da Folha de S.Paulo entre 2000 e 2021, nos quais verificamos operações discursivas das categorias consciência ocidental do negro (racismo) e consciência negra do negro (autodefinição), de acordo com o conceito de razão negra.

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Farias, João Paulo Bloch de, Juliana Maria Vaz Pimentel, and Letícia Cassiano Santos. "Turismo étnico-afro: uma possível alternativa para empreendedorismo e empoderamento negro no Brasil." Caderno Virtual de Turismo 21, no. 2 (August 31, 2021): 51. http://dx.doi.org/10.18472/cvt.21n2.2021.1867.

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Este primeiro ensaio versa sobre o preconceito racial enfrentado pela população negra no Brasil e o turismo étnico-afro como um segmento do turismo cultural capaz de empoderar os empreendedores negros. O objetivo do presente estudo tenciona elucidar o legado cultural dos negros no Brasil e contribuir para a desconstrução da imagem do negro atrelada à escravidão, visando assim, demonstrar que o turismo étnico-afro-mediante a comercialização de roteiros étnico-afros-, além de valorizar a cultura negra, propicia a abertura de postos de trabalho voltados ao empreendedor negro. Para o transcorrer da pesquisa, pautamonos na metodologia qualitativa de caráter exploratório como maneira de compreendermos a forma como o turismo étnico-afro propicia o resgate da memória dos negros e transforma em um atrativo que valoriza a cultura negra. Mediante dados estatísticos e referenciais teóricos que abordam a temática em tela, podemos concluir que o turismo étnico-afro também atua, mesmo que de forma indireta, em questões que envolvem aspectos políticos, sociais, econômicos e culturais dos negros, transformando-se, assim, em uma atividade capaz de empoderar o empreendedor negro e valorizar a cultura negra e afrodescendente.

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Rouse, Josefa. "IFIGÊNIA: DE PROSTITUTA À HEROÍNA." Sankofa (São Paulo) 12, no. 23 (August 8, 2019): 51–83. http://dx.doi.org/10.11606/issn.1983-6023.sank.2019.169148.

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Este trabalho analisa a representação da mulher negra a partir das obras Sortilégio – Mistério Negro (1951) e Sortilégio II - Mistério Negro de Zumbi Redivivo (1976/77), dramaturgia escrita e reescrita por Abdias do Nascimento no bojo do Teatro Experimental do Negro. Nos debruçamos em especial às questões relativas às personagens femininas (Ifigênia, as Ialorixás e o coro de mulheres). Perpassamos questões do feminismo negro e suas interseccionalidades, a religiosidade transposta para o discurso teatral, a afetividade da mulher negra e o lugar de fala destas mulheres no teatro nacional com o intuito de pensar suas implicações no teatro moderno e contemporâneo e observar como a cena pode colaborar para lançar outro olhar sobre suas imagens, a partir das mudanças de uma obra a outra, como no percurso da personagem Ifigênia, mais contundente - ainda que dentro de um estereótipo controverso. A pesquisa desdobrou-se a partir de revisão bibliográfica, com a finalidade de apontar para certas modalidades de representação da mulher negra que se apresentam como estereótipos dominantes, a fim de repensar processos de desumanização vividos em especial por mulheres negras, e apontar caminhos emancipatórios que possam revelar suas subjetividades por meio da cena.

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