Relevant bibliographies by topics / Neglected tropical diseases, migrants, global health

Academic literature on the topic 'Neglected tropical diseases, migrants, global health'

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Published: 11 March 2023

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Journal articles on the topic "Neglected tropical diseases, migrants, global health"

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Agudelo Higuita, Nelson Iván, Carlos Franco-Paredes, Andrés F. Henao-Martínez, Norman L. Beatty, Jennifer Manne-Goehler, and Colin J. Forsyth. "Chagas Disease and Domestic Medical Screening Guidance for Newly Arrived Individuals Under a Humanitarian-Based Immigration Status: A Call for Action." American Journal of Tropical Medicine and Hygiene 107, no. 5 (November 14, 2022): 960–63. http://dx.doi.org/10.4269/ajtmh.22-0309.

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ABSTRACT. Chagas disease is considered one of the most important neglected tropical diseases in the Western Hemisphere, given its morbidity, mortality, and societal and economic burden. The United States has the fifth highest global burden of Chagas disease. Every year, thousands of migrant people from Latin America and throughout the globe travel to the U.S.– Mexico border searching for asylum. The U.S. CDC’s Guidance for the U.S. Domestic Medical Examination for Newly Arriving Refugees provides recommendations to safeguard the health of individuals who enter the United States with a humanitarian-based immigration status as defined by the CDC’s guidance under Key Considerations and Best Practices. We encourage the inclusion of Trypanosoma cruzi infection screening recommendations in this guidance as an important step toward understanding the risk and burden of Chagas disease in this vulnerable population, strengthening their access to care and contributing to the 2030 objectives of the WHO’s neglected tropical diseases road map.
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Vanderslott, Samantha. "Neglected Tropical Diseases." Nature and Culture 15, no. 1 (March 1, 2020): 78–110. http://dx.doi.org/10.3167/nc.2020.150105.

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Neglected tropical diseases show how a disease group can be formed to compete in the global health policy marketplace. The naming and branding of a new disease category is used to organize activities, direct attention and resources, and rationalize the governance of diseases. The politics of classification involves processes of negotiation and conceptual development by key actors. Here, discussions about central characteristics, naming, and inclusion and exclusion criteria are rarely settled. Contradictions are present in the “tropical” and “neglected” characterizations, as well as choices of universalist rather than particularist approaches. Interacting with these considerations is a continued progression in means of dealing with disease from health actors and changing attributes of diseases in populations.
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Hotez, Peter J. "Global urbanization and the neglected tropical diseases." PLOS Neglected Tropical Diseases 11, no. 2 (February 23, 2017): e0005308. http://dx.doi.org/10.1371/journal.pntd.0005308.

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Hotez, Peter J. "Ten Global “Hotspots” for the Neglected Tropical Diseases." PLoS Neglected Tropical Diseases 8, no. 5 (May 29, 2014): e2496. http://dx.doi.org/10.1371/journal.pntd.0002496.

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Mackey, Tim K., and Bryan A. Liang. "Global health policy coordination to address neglected tropical diseases." Tropical Medicine & International Health 17, no. 9 (July 29, 2012): 1053–56. http://dx.doi.org/10.1111/j.1365-3156.2012.03049.x.

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Hotez, Peter J. "Global Christianity and the Control of Its Neglected Tropical Diseases." PLoS Neglected Tropical Diseases 8, no. 11 (November 20, 2014): e3135. http://dx.doi.org/10.1371/journal.pntd.0003135.

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Bharadwaj, Mitasha, Michel Bengtson, Mirte Golverdingen, Loulotte Waling, and Cees Dekker. "Diagnosing point-of-care diagnostics for neglected tropical diseases." PLOS Neglected Tropical Diseases 15, no. 6 (June 17, 2021): e0009405. http://dx.doi.org/10.1371/journal.pntd.0009405.

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Inadequate and nonintegrated diagnostics are the Achilles’ heel of global efforts to monitor, control, and eradicate neglected tropical diseases (NTDs). While treatment is often available, NTDs are endemic among marginalized populations, due to the unavailability or inadequacy of diagnostic tests that cause empirical misdiagnoses. The need of the hour is early diagnosis at the point-of-care (PoC) of NTD patients. Here, we review the status quo of PoC diagnostic tests and practices for all of the 24 NTDs identified in the World Health Organization’s (WHO) 2021–2030 roadmap, based on their different diagnostic requirements. We discuss the capabilities and shortcomings of current diagnostic tests, identify diagnostic needs, and formulate prerequisites of relevant PoC tests. Next to technical requirements, we stress the importance of availability and awareness programs for establishing PoC tests that fit endemic resource-limited settings. Better understanding of NTD diagnostics will pave the path for setting realistic goals for healthcare in areas with minimal resources, thereby alleviating the global healthcare burden.
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Costa, Maria Beatriz Silva, and Camila Martins de Oliveira. "Endophytic Fungi in the Fight Against Neglected Tropical Diseases." Mini-Reviews in Medicinal Chemistry 20, no. 16 (November 10, 2020): 1683–93. http://dx.doi.org/10.2174/1389557520666200624193300.

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Neglected tropical diseases are a serious global public health problem and they are one of the main causes of mortality and morbidity, especially in underdeveloped countries. These diseases have several implications for health and they are considered a priority in global eradication programs for disease control. The aim of this mini-review is to report recent studies on the fight against neglected diseases, namely dengue fever, chikungunya, zika, malaria protozoa, Chagas disease, leishmaniasis, schistosomiasis helminths, filariasis, and tuberculosis bacteria using extracts and isolated substances of endophytic fungi based on their bioactivity profiles in relation to these diseases.
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Bronstein, A. M., Yu V. Lobzin, S. S. Kozlov, and A. B. Birg. "From primitive jungle medicine to tropical medicine: history of progress and current challenges in the tropical disease control." Journal Infectology 14, no. 2 (July 12, 2022): 5–13. http://dx.doi.org/10.22625/2072-6732-2022-14-2-5-13.

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Neglected tropical diseases (NTDs) have long been overlooked in the global health agenda. The article is intended to generate information in consideration of the history of colonization of tropical countries with a special focus on tropical diseases especially common in the army during colonial wars and throughout the colonial era. Extreme poverty and warm tropical climates are the two most potent forces promoting the spread of neglected tropical diseases. European colonial doctors made valuable contribution towards understanding them and discovery these diseases. Large outbreaks of infectious and tropical diseases occurred in the Army throughout the colonial era, strongly influenced the formation of the Army Medical Services including provision for teaching and research. Subsequent improvements in prevention, diagnosis and treatment reduced the mortality from tropical diseases. Now in an era of “globalized” environment of interdependent trade, travel, migration, and international economic markets, many factors play an important role in the rise, emergence, and reemergence of tropical infectious disease, which necessitates a coordinated, global response. Many of the emerging and reemerging infectious diseases are also “neglected,” meaning they impact the world’s poorest and lack adequate funding and innovation for prevention and treatment, with some not adequately identified or studied. Although progress has been made in the management of neglected disease, there remains much work to be done. During the coming decade the global response will be able to further build on today’s successes, align with the new global health and development frameworks.
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Kuper, Hannah. "Neglected tropical diseases and disability—what is the link?" Transactions of The Royal Society of Tropical Medicine and Hygiene 113, no. 12 (March 20, 2019): 839–44. http://dx.doi.org/10.1093/trstmh/trz001.

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AbstractNeglected tropical diseases (NTDs) are a diverse group of infectious conditions that vary in their epidemiology, impact and control. They are among the most common conditions globally, affecting approximately one billion people. Many NTDs have long-term consequences, such as visual and physical impairments. As a result, people with NTDs may have difficulties in carrying out activities or participating in society—in other words, NTDs can cause disabilities. Additionally, NTDs are often strongly linked to stigma and can have mental health consequences. It is therefore important to incorporate rehabilitation within NTD programmes. Rehabilitation can be conceptualized narrowly in terms of the provision of clinical services (e.g. physiotherapy and assistive devices) or, more broadly, including efforts to improve employment, overcome stigma and enhance social participation of people with disabilities. Approximately 15% of the global population has a disability, and this large group must be considered when designing NTD programmes. Improving the inclusion of people with disabilities may require adaptations to NTD programmes, such as making them physically accessible or training staff about disability awareness. Without incorporating disability within NTD programmes, the quality of life of people with NTDs will suffer and global targets for elimination and management of NTDs will not be met.
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Dissertations / Theses on the topic "Neglected tropical diseases, migrants, global health"

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Bardosh, Kevin Louis. "Public health at the margins : local realities and the control of neglected tropical diseases in Eastern Africa." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15832.

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Neglected Tropical Diseases (NTDs) are both causes and manifestations of poverty in developing countries. Recent advocacy efforts have increased the profile of NTDs, and led to bold new control and elimination targets set for 2020 by the World Health Organisation. However there are multifaceted challenges in effectively implementing NTD interventions in resource-poor contexts that need to be understood and engaged. While there is a growing call by researchers and international agencies for a science of global health delivery to understand these complexities, the exact nature of this science remains contested. This thesis contributes to these debates by advancing a critical social science perspective on the factors that mediate intervention effectiveness for NTD control. Grounded in a social constructivist approach using mixed methods, it critiques prevailing orthodoxies by unpacking the nature, processes and outcomes of three large-scale NTD prevention programmes in Eastern Africa. Focused on different diseases, these case studies represent different types of intervention approaches: top-down, participatory and public-private partnership. The thesis traces the social, technical and environmental processes that mediate the delivery, adoption and use of particular health technologies, such as pit latrines, insecticides and vaccination. Together, these case studies reveal surprisingly similar reasons for why many interventions do not perform according to expectations. Despite new approaches that claim to overcome stereotypical challenges of top-down planning, narrow technocratic perspectives continue to play a defining role in maintaining disjunctions between global aspirations, local realities and intervention outcomes. New perspectives and changes in orientation are needed that emphasise flexibility, learning and adaptability to local contexts. Towards this end, the thesis outlines a conceptual framework based on a comparative analysis of the case studies that highlights five interrelated domains where effectiveness is determined: geographical/livelihood variation, local agency, incentives, the socio-materiality of technology and planning/governance. I argue that addressing the shortcomings of contemporary interventions requires that programme planners actively engage these domains by seeking to “order complexity.” Greater integration of social science perspectives into the management of NTD programmes would provide significant benefit. In these ways, the thesis contributes to wider debates about the nature of global health interventions and the influence of local contexts in mediating efforts to improve the health and wellbeing of the world’s poor and marginalised.
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Hastings, Julie Dawn. "Rumours and riots : local responses to mass drug administration for the treatment of neglected tropical diseases among school-aged children in Morogoro region, Tanzania." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/7467.

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In August 2008, a biomedical intervention providing free drugs to school aged children to treat two endemic diseases –schistosomiasis haematobium and soil-transmitted helminths - in Morogoro region, Tanzania, was suspended after violent riots erupted. Parents and guardians rushed to schools to prevent their children taking the drugs when they heard reports of children dying in Morogoro town after receiving treatment. When pupils heard these reports, many of those who had swallowed the pills began to complain of dizziness and fainted. In Morogoro town hundreds of pupils were rushed to the Regional Hospital by their parents and other onlookers. News of these apparent fatalities spread throughout the region, including to Doma village where I was conducting fieldwork. Here, protesting villagers accused me of bringing the medicine into the village with which to “poison” the children and it was necessary for me to leave the village immediately under the protection of the Tanzanian police. This thesis, based on eleven months fieldwork between 2007 and 2010 in Doma village and parts of Morogoro town, asks why was this biomedical intervention so vehemently rejected? By analysing local understandings and responses to the mass distribution of drugs in relation to the specific historical, social, political, and economic context in which it occurred, it shows that there was a considerable disjuncture between biomedical understandings of these diseases, including the epidemiological rationale for the provision of preventive chemotherapy, and local perspectives. Such a disjuncture, fuelled by the reports of fatalities and the pupil’s fainting episodes brought about considerable conjecture both locally and nationally, that the drugs had been faulty, counterfeit, or hitherto untested on humans. Among many of the poorer inhabitants of Morogoro town, there was suspicion that this had been a covert sterilization campaign. From an official perspective, such conjecture was dismissed as mere rumour, proliferated by “ignorant” people. However, from an anthropological perspective, these ‘rumours’ reveal profound local anxieties including a pervasive fear that poor Africans are being targeted for covert eugenics projects by governments in the industrialized world. The thesis also shows that many of the assumptions embedded in global policies seeking to control neglected tropical diseases are mistaken. Indeed, it is suggested that it is unlikely that schistosomiasis haematobium and soil-transmitted helminths will be controlled so long as policy makers persist with the idea that one policy, designed by staff working for the World Health Organisation – with minor modifications added in Dar es Salaam - can be rolled out uniformly, irrespective of the political, social and economic context in which the programme occurs.
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Marrone, Rosalia. "Neglected Tropical Diseases and migrants: a global health challenge amid access barriers and lack of gold standard diagnostics." Doctoral thesis, 2023. https://hdl.handle.net/11562/1085312.

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This thesis concerns the Health of Migrants, with particular attention to "neglected" tropical diseases (NTDs) and other infections, and is based on the experience of daily screening and clinical work carried out for several years at the outpatient clinic of the National Institute for Migration and Poverty ( INMP) in Rome, and on scientific collaboration with the IRCCS Sacro Cuore Don Calabria for Infectious and Tropical Diseases and the University of Verona. The thesis is structured in 5 main chapters, each of which consists of a short introduction and one or more scientific articles (6 articles in total). Each chapter develops from a specific research question. Chapter 1 deals with the institutional and socio-cultural barriers that hinder migrants' access to the national health system, having as a case study the anthropological approach to Chagas' disease screening in Latin American migrants. Through the case study, a general approach to foreign patients that takes into account cultural, social and linguistic differences is indicated. Chapter 2 deals with infectious disease screening in neglected and 'invisible' persons: minors and trafficked Nigerian women, also addressing issues such as barriers to access to care for migrants. The first paper, on a large cohort, shows that migrant minors are generally healthy and do not pose a significant risk to the native population. The second work surprisingly shows that, in trafficked sex workers, noncommunicable NTDs, such as strongyloidiasis and schistosomiasis, are much more common than sexually transmitted diseases (STDs) and HIV. Chapter 3 describes the process that led, through complex inter-institutional work in which I was personally involved, as a member of the technical group and writing committee,to the first national guidelines in Italy for infectious disease screening in asylum seekers and refugees, which added two important non-communicable NTDs, namely strongyloidiasis and schistosomiasis, to the traditional communicable infections. Chapter 4 describes, through the largest prospective study ever conducted in Europe, the prevalence of the two NTDs and transmissible infections in African refugees and asylum seekers, noting an impressive number of people with urinary and intestinal schistosomiasis and (to a lesser extent) strongyloidiasis, and emphasizes the lack of a diagnostic gold standard for the two infections and the need for improved 4 screening tests. Chapter 5 deals with the evaluation of a new serological test (not yet commercially available) for strongyloidiasis, demonstrating reasonably good sensitivity and specificity. In the same line, Chapter 5 goes on to indicate current and future lines of research to improve the screening and diagnosis of schistosomiasis. We conclude that the healthcare management of migrants is extremely complex and challenging, involving at the same time science, ethics, solidarity, rights, politics and determinants of health, thus becoming a global health challenge.
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Books on the topic "Neglected tropical diseases, migrants, global health"

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Crompton, D. W. T. (David William Thomasson), 1937-, Daumerie Denis, Peters Patricia, Savioli Lorenzo, and World Health Organization, eds. Working to overcome the global impact of neglected tropical diseases: First WHO report on neglected tropical diseases. Geneva, Switzerland: World Health Organization, 2010.

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Hotez, Peter J. Forgotten people, forgotten diseases: The neglected tropical diseases and their impact on global health and development. Washington, DC: ASM Press, 2008.

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Hotez, Peter J. Forgotten people, forgotten diseases: The neglected tropical diseases and their impact on global health and development. 2nd ed. Washington, DC: ASM Press, 2013.

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United, States Congress House Committee on Foreign Affairs Subcommittee on Africa Global Health Global Human Rights and International Organizations. Addressing the neglected diseases treatment gap: Hearing before the Subcommittee on Africa, Global Health, Global Human Rights, and International Organizations of the Committee on Foreign Affairs, House of Representatives, One Hundred Thirteenth Congress, first session, June 27, 2013. Washington, D.C: U.S. Government Printing Office, 2013.

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Hotez, Peter J. Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development. Wiley & Sons, Limited, John, 2013.

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Forgotten people, forgotten diseases: The neglected tropical diseases and their impact on global health and development. 2nd ed. Washington, DC: ASM Press, 2013.

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Hotez, Peter J. Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development. Wiley & Sons, Limited, John, 2021.

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Hotez, Peter J. Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development. ASM Press, 2013.

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Hotez, Peter J. Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development. Wiley & Sons, Incorporated, John, 2021.

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Hotez, Peter J. Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development. Wiley & Sons, Incorporated, John, 2021.

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Book chapters on the topic "Neglected tropical diseases, migrants, global health"

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De Maio, Fernando. "Neglected Tropical Diseases." In Global Health Inequities, 78–102. London: Macmillan Education UK, 2014. http://dx.doi.org/10.1007/978-1-137-40063-5_5.

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Uwland, Aimée, and David Townend. "The Influence of Intellectual Property Protection on Drug Development for Neglected Tropical Diseases." In Making Global Health Care Innovation Work, 181–97. New York: Palgrave Macmillan US, 2014. http://dx.doi.org/10.1057/9781137456038_10.

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Omitola, Omotayo Modupeola. "Framing Poverty in Nigerian Online Media Reports on the Inaugural Neglected Tropical Diseases Day." In Health Crises and Media Discourses in Sub-Saharan Africa, 127–45. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-95100-9_8.

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AbstractNeglected tropical diseases (NTDs) are so called because they affect the poor people in the low income tropical and subtropical regions of the world which do not draw much global attention. The diseases can be totally cured with adequate clinical interventions; however, their persistence, in spite of the availability of drugs, brought about the dedication of January 30 as a world awareness day to focus on them. This chapter looks into online media reports about the day in Nigeria, the country with 45% of the disease burden in sub-Saharan Africa. A total of 34 reports turned up by a Google search were sampled. Using framing theory, the chapter identifies how the reports, relying on the testimonies of medical experts, rightly highlight poverty as the major driver of the diseases. They are, however, silent about the need to eradicate poverty in order to eradicate the diseases, thus neglecting it (poverty) at a critical point. This creates an amputated frame that does not deliver on how the incidence of the diseases can be holistically tackled. Journalists are urged to conduct independent research when reporting on technical issues in order to complement the testimonies of experts and thus complete their frames.
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Hassoun, Nicole. "The Global Health Impact Index." In Measuring the Global Burden of Disease, edited by Nir Eyal, Samia A. Hurst, Christopher J. L. Murray, S. Andrew Schroeder, and Daniel Wikler, 309–20. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780190082543.003.0018.

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There are many multi-attribute indicators of countries’ levels of wealth, poverty, inequality, and development. Some of these indicators, such as the Human Development Index, consider aspects of population health. This chapter presents the first multi-attribute indicator comparing the impact of key drugs on poor health across the world: the Global Health Impact (GHI) index. It evaluates the impact of key drugs on malaria, tuberculosis, HIV/AIDS, and several neglected tropical diseases in every country in the world. The chapter includes a discussion of possible future directions for research and ends with a discussion of the GHI index and numerous questions that remain regarding its methodology and implementation.
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Inceboz, Tonay. "One Health Concept against Schistosomiasis: An Overview." In Infectious Diseases. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106912.

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Schistosomiasis (bilharziasis) is a parasitic disease caused by Schistosoma spp. that belongs to trematode worms. These worms are known as “blood parasites”. This disease is included in “neglected tropical diseases” and “water-borne diseases”. The main species are Schistosoma (S.) haematobium, S. japonicum, S. mansoni, S. intercalatum, S. mekongi, S. guineensis and S. intercalatum, though there are more than 20 different species. The parasite in the definitive host may affect many organs and systems. The disease may become chronic and lasts 3–8 years and even up to 20–30 years. The definitive host is primarily human; however, in endemic areas animals such as monkeys, cattle, horses, rodents, cats, dogs are reservoirs. According to World Health Organization (WHO), schistosomiasis affects 250 million people, and causes 1.9 million deaths yearly in endemic areas. Moreover, due to global warming, the spread of the disease may increase. The effective way to fight against schistosomiasis is following the “one-health system”. Indeed, to overcome or “eradicate” this disease, we have to strive against different forms at different evolutionary stages of the worm such as, forms in humans, domestic or wild animals, and freshwater snails. If we combine the knowledge of professionals, we may achieve this goal.
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Olorunlana, Adetayo. "Dancing in a Cycle: Global Health Agenda and Schistosomiasis Control in Africa." In Parasitic Helminths and Zoonoses - From Basic to Applied Research [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.103164.

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Schistosomiasis and other Neglected Tropical diseases (NTDs) affect about 2 billion people globally. Africa shares approximately 90% of the global burden of schistosomiasis disease. Despite, World Health Organization (WHO) effort to control the disease, it remains neglected in most African countries. Historically, schistosomiasis is as long as 4,000 years in Africa, but lack accurate data and commitment to combat the disease. Control programs exclude adults in Mass Drug Administration (MDAs), and water, sanitation, and hygiene (WASH) as Praziquantel drug is used for the treatment. However, migratory patterns of the neglected population and the interplay of social, economic, political, and cultural factors introduce the disease into previously eliminated or/and new areas. The question is would Africa be able to achieve the new goals of the WHO NTDs 2021–2030 Roadmap, for schistosomiasis elimination? The chapter argued for and against if Africa changes the current top-down approach to schistosomiasis control and incorporates a dynamic approach. Or if the previous pattern of late implementation, dependent on only one drug and shifting focus to other diseases of relevance continues. If a new approach is not adopted the dance in the cycle has just begun.
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Chan, Emily Ying Yang. "Communicable Disease and Control." In Essentials for Health Protection, 93–123. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198835479.003.0005.

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Control of communicable diseases is one of the core components in health protection practice. This chapter describes key concepts and principles related to communicable diseases and their management. According to World Health Organization, the number of deaths due to communicable diseases reduced from 12.1 million in 2000 to 9.5 million in 2012. However, malaria, tuberculosis, HIV/AIDS, and neglected tropical diseases remain the major health challenges for the global community. Moreover, new emergent and re-emerging diseases constantly present new health risks. For the coming decades, globalization, changing behavioural patterns, lifestyle, and technological outcomes will pose major challenge to communicable disease control and management. The increasingly urbanized lifestyle and high-density-based living will also render most city-based communities vulnerable to living environmental pressure and communicable disease risks. Effectiveness and success in future communicable disease control rely on global coordination and cooperation.
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Alqassim, Ahmad, and Maged El-Setouhy. "Impact of Poverty on Health." In Healthcare Access - New Threats, New Approaches [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108704.

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Poverty is not merely the absence of money but the absence of resources to get the necessities of life. Poverty and health are always in a reciprocal relationship. This relation came to light in 1948 when the WHO defined health as complete physical, mental and social wellbeing. In 1987, the Alma-Ata declaration opened the discussion on health inequity. This opened the door for thousands of projects, proposals, and publications on this relation. Although the relationship between poverty and infectious diseases was clear, there was inequity in funding. The Global Fund invests US$ 4 billion annually for AIDS, tuberculosis, and Malaria, while other diseases lack funds. That is why they were considered neglected tropical diseases. However, the relationship between health and poverty is not limited to infectious diseases but includes noninfectious problems like malnutrition and injuries. In this chapter, we will assess the association between poverty as a predictor and health as an outcome.
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de Souza, Anacleto S., Leonardo G. Ferreira, and Adriano D. Andricopulo. "2D and 3D QSAR Studies on a Series of Antichagasic Fenarimol Derivatives." In Pharmaceutical Sciences, 956–77. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1762-7.ch037.

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Chagas disease is one of the most important neglected tropical diseases. Endemic in Latin America, the disease is a global public health problem, affecting several countries in North America, Europe, Asia and Oceania. The disease affects around 8-10 million people worldwide and the limited treatments available present low efficacy and severe side effects, highlighting the urgent need for new therapeutic options. In this work, the authors developed QSAR models for a series of fenarimol derivatives exhibiting anti-T. cruzi activity. The models were constructed using the Hologram QSAR (HQSAR), Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) methods. The QSAR models presented substantial predictive ability for a series of test set compounds (HQSAR, r2pred = 0.66; CoMFA, r2pred = 0.82; and CoMSIA, r2pred = 0.76), and were valuable to identify key structural features related to the observed trypanocidal activity. The results reported herein are useful for the design of novel derivatives having improved antichagasic properties.
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