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1

Strug, Joanna. "Mutation Testing Approach to Negative Testing." Journal of Engineering 2016 (2016): 1–13. http://dx.doi.org/10.1155/2016/6589140.

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Negative testing deals with an important problem of assessing a system ability to handle unexpected situations. Such situations, if unhandled, may lead to system failures that in some cases can have catastrophic consequences. This paper presents a mutation testing-based approach for generation of test cases supporting negative testing. Application of this approach can provide, in a systematic and human-unbiased way, test cases effectively testing wide range of unexpected situations. Thus, it can contribute to improvement of a tested system. The paper formally defines mutation operators used to control the generation process, describes a generic framework for the generation and execution of the test cases, and explains how to interpret results.
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2

Kolenikov, Stanislav, and Kenneth A. Bollen. "Testing Negative Error Variances." Sociological Methods & Research 41, no. 1 (February 2012): 124–67. http://dx.doi.org/10.1177/0049124112442138.

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3

Massad, L. Stewart, Gypsyamber DʼSouza, Fang Tian, Howard Minkoff, Mardge Cohen, Rodney L. Wright, Christine Colie, and Nancy A. Hessol. "Negative Predictive Value of Pap Testing." Obstetrics & Gynecology 120, no. 4 (October 2012): 791–97. http://dx.doi.org/10.1097/aog.0b013e31826a8bbd.

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4

Minarechová, Michaela. "Negative impacts of high-stakes testing." Journal of Pedagogy / Pedagogický casopis 3, no. 1 (January 1, 2012): 82–100. http://dx.doi.org/10.2478/v10159-012-0004-x.

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Negative impacts of high-stakes testingHigh-stakes testing is not a new phenomenon in education. It has become part of the education system in many countries. These tests affect the school systems, teachers, students, politicians and parents, whether that is in a positive or negative sense. High-stakes testing is associated with concepts such as a school's accountability, funding and parental choice of school. The study aims to explain high-stakes testing, how it is created and developed in selected countries and look at the negative impacts of tests on various actors within this relationship.
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5

Evans, Mark I., Ming Chen, and David W. Britt. "Understanding False Negative in Prenatal Testing." Diagnostics 11, no. 5 (May 17, 2021): 888. http://dx.doi.org/10.3390/diagnostics11050888.

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A false negative can happen in many kinds of medical tests, regardless of whether they are screening or diagnostic in nature. However, it inevitably poses serious concerns especially in a prenatal setting because its sequelae can mark the birth of an affected child beyond expectation. False negatives are not a new thing because of emerging new tests in the field of reproductive, especially prenatal, genetics but has occurred throughout the evolution of prenatal screening and diagnosis programs. In this paper we aim to discuss the basic differences between screening and diagnosis, the trade-offs and the choices, and also shed light on the crucial points clinicians need to know and be aware of so that a quality service can be provided in a coherent and sensible way to patients so that vital issues related to a false negative result can be appropriately comprehended by all parties.
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Chaudhry, Hina, Michelle Sholzberg, and Katerina Pavenski. "Adamts-13 Inhibitor Testing Is Often Negative on Initial Testing." Blood 132, Supplement 1 (November 29, 2018): 5051. http://dx.doi.org/10.1182/blood-2018-99-119399.

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Abstract Background: Thrombotic thrombocytopenic purpura (TTP) presents with microangiopathic hemolytic anemia and thrombocytopenia and is caused by severe ADAMTS13 deficiency. TTP can be the result of autoantibodies to ADAMTS13 or genetic defect in the ADAMTS13 gene. ADAMTS-13 is an enzyme that specifically cleaves unusually large von Willebrand Factor (VWF) multimers which mediate platelet thrombus formation under high shear. When ADAMTS13 is deficient, unusually large VWF multimers accumulate causing excessive platelet aggregation and thrombosis in the microvasculature. Methods: St. Michael's Hospital, Toronto is home to a large reference laboratory for special coagulation. We use a commercial ELISA Technoclone Technozym ADAMTS-13 activity assay for the determination of ADAMTS-13 activity and Technoclone Technozym ADAMTS-13 inhibitor assay to identify anti-ADAMTS-13 antibodies. We send samples to another Canadian laboratory for validation of our results as they use an in-house ELISA assay for ADAMTS13 activity and anti-ADAMTS13 antibody. Results: We performed a retrospective review of all ADAMTS13 activity tests performed by our laboratory between January 1, 2013 and June 30, 2018. The total number of tests was 466 from 203 unique patients. 24% had an ADAMTS-13 activity under 10% (N = 144) which is consistent with the diagnosis of TTP. When specimens with severe ADAMTS-13 deficiency were tested for presence of anti-ADAMTS13 antibody, 46% were negative. Four of these specimens were sent to the other laboratory and all had detectable, albeit very low titre, inhibitors. Furthermore, on repeated testing over the study period, the vast majority of patients who presented with low ADAMTS13 activity and no detectable antibody subsequently became antibody positive. Fifty-two patients remained antibody negative by our internal and send-out testing. Five of them were known to have or were subsequently diagnosed with hereditary TTP (hTTP). Only one patient continues to have negative antibody but whose clinical course is not consistent with hTTP. Conclusions: We found that a commercial ADAMTS13 (Technoclone Technozym) antibody assay is falsely negative in a substantial proportion of patients with autoimmune TTP, the majority of which likely had a low titer inhibitor, below the threshold of test detection. More sensitive assays and/or repeated testing, presumably as inhibitor titre increases during the course of the disease, may detect antibody presence in the majority of samples of patients with autoimmune TTP. This is an important finding as this could impact the types of therapies offered to patients with negative antibody screens and may also avoid unnecessary, expensive genetic testing . Disclosures No relevant conflicts of interest to declare.
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7

Mulligan, Neil W., and Daniel J. Peterson. "The negative testing and negative generation effects are eliminated by delay." Journal of Experimental Psychology: Learning, Memory, and Cognition 41, no. 4 (2015): 1014–25. http://dx.doi.org/10.1037/xlm0000070.

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8

Bennet, Neil. "BRCA1 testing for triple-negative breast cancer." Lancet Oncology 13, no. 4 (April 2012): e143. http://dx.doi.org/10.1016/s1470-2045(12)70078-5.

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9

Peterson, Daniel J., and Neil W. Mulligan. "The negative testing effect and multifactor account." Journal of Experimental Psychology: Learning, Memory, and Cognition 39, no. 4 (2013): 1287–93. http://dx.doi.org/10.1037/a0031337.

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10

Kerr, Alastair, Mohammed Shareef, Robert Dawe, and James Ferguson. "Photopatch testing negative in systemic quinine phototoxicity." Photodermatology, Photoimmunology & Photomedicine 26, no. 3 (June 2010): 151–52. http://dx.doi.org/10.1111/j.1600-0781.2010.00503.x.

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11

Lee, H. T. "Anaphylaxis to cisatracurium following negative skin testing." Yearbook of Anesthesiology and Pain Management 2007 (January 2007): 30–31. http://dx.doi.org/10.1016/s1073-5437(08)70033-0.

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12

Fraser, B. A., and J. A. Smart. "Anaphylaxis to Cisatracurium following Negative Skin Testing." Anaesthesia and Intensive Care 33, no. 6 (December 2005): 816–19. http://dx.doi.org/10.1177/0310057x0503300620.

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13

Intons-Peterson, M. J., Paola Rocchi, Tara West, Kimberly McLellan, and Amy Hackney. "Aging, optimal testing times, and negative priming." Journal of Experimental Psychology: Learning, Memory, and Cognition 24, no. 2 (1998): 362–76. http://dx.doi.org/10.1037/0278-7393.24.2.362.

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14

Eleswarapu, Venkat R., and Rex Thompson. "Testing for negative expected market return premia." Journal of Banking & Finance 31, no. 6 (June 2007): 1755–70. http://dx.doi.org/10.1016/j.jbankfin.2006.08.005.

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15

Gerace, Kali, and Elizabeth Phillips. "Penicillin Allergy Label Persists Despite Negative Testing." Journal of Allergy and Clinical Immunology 135, no. 2 (February 2015): AB113. http://dx.doi.org/10.1016/j.jaci.2014.12.1304.

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16

Gerace, Kali Svarczkopf, and Elizabeth Phillips. "Penicillin allergy label persists despite negative testing." Journal of Allergy and Clinical Immunology: In Practice 3, no. 5 (September 2015): 815–16. http://dx.doi.org/10.1016/j.jaip.2015.05.019.

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17

Brooks, Zoe C., and Saswati Das. "COVID-19 Testing." American Journal of Clinical Pathology 154, no. 5 (August 28, 2020): 575–84. http://dx.doi.org/10.1093/ajcp/aqaa141.

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Abstract Objectives To illustrate how patient risk and clinical costs are driven by false-positive and false-negative results. Methods Molecular, antigen, and antibody testing are the mainstay to identify infected patients and fight the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To evaluate the test methods, sensitivity (percent positive agreement [PPA]) and specificity (percent negative agreement [PNA]) are the most common metrics utilized, followed by the positive and negative predictive value—the probability that a positive or negative test result represents a true positive or negative patient. The number, probability, and cost of false results are driven by combinations of prevalence, PPA, and PNA of the individual test selected by the laboratory. Results Molecular and antigen tests that detect the presence of the virus are relevant in the acute phase only. Serologic assays detect antibodies to SARS-CoV-2 in the recovering and recovered phase. Each testing methodology has its advantages and disadvantages. Conclusions We demonstrate the value of reporting probability of false-positive results, probability of false-negative results, and costs to patients and health care. These risk metrics can be calculated from the risk drivers of PPA and PNA combined with estimates of prevalence, cost, and Reff number (people infected by 1 positive SARS-CoV-2 carrier).
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18

Jain, Tarun, and Bijendra Nath Jain. "Infection Testing at Scale: An Examination of Pooled Testing Diagnostics." Vikalpa: The Journal for Decision Makers 46, no. 1 (March 2021): 13–26. http://dx.doi.org/10.1177/02560909211018906.

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Executive Summary In pandemics or epidemics, public health authorities need to rapidly test a large number of individuals without adequate testing kits. We propose a testing protocol to accelerate infection diagnostics by combining multiple samples, and in case of positive results, re-test individual samples. The key insight is that a negative result in the first stage implies negative infection for all individuals. Thus, a single test could rule out infection in multiple individuals. Using simulations, we show that this protocol reduces the required number of testing kits, especially when the infection rate is low, alleviating a key bottleneck for public health authorities in times of pandemics and epidemics such as COVID-19. Our proposed protocol is expected to be more effective when the infection rate is low, which suggests that it is better suited for early stage and large-scale, population-wide testing. However, the managerial trade-off is that the protocol has costs in additional time for returning test results and an increased number of false negatives. We discuss applications of pooled testing in understanding population-wide testing to understand infection prevalence, to diagnose infections in high-risk groups of individuals, and to identify disease cold spots.
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19

Hoffman, Richard M., Thomas Denberg, William C. Hunt, and Ann S. Hamilton. "Prostate Cancer Testing following a Negative Prostate Biopsy: Over Testing the Elderly." Journal of General Internal Medicine 22, no. 8 (June 7, 2007): 1139–43. http://dx.doi.org/10.1007/s11606-007-0248-7.

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20

Dewan, Mohit A., Andrew R. Harrison, and Michael S. Lee. "False-negative apraclonidine testing in acute Horner syndrome." Canadian Journal of Ophthalmology 44, no. 1 (February 2009): 109–10. http://dx.doi.org/10.3129/i08-162.

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21

Masket, Samuel, Zsófia Magdolna Rupnik, Nicole R. Fram, and Ryan J. Vikesland. "Binocular Goldmann visual field testing of negative dysphotopsia." Journal of Cataract & Refractive Surgery 46, no. 1 (January 2020): 147–48. http://dx.doi.org/10.1097/j.jcrs.0000000000000001.

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22

McKay, Shawn P., Danny Meslemani, Robert J. Stachler, and John H. Krouse. "Intradermal positivity after negative prick testing for inhalants." Otolaryngology–Head and Neck Surgery 135, no. 2 (August 2006): 232–35. http://dx.doi.org/10.1016/j.otohns.2006.03.017.

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23

Liversidge, Kylie, Rodrigo Guzmán Rojas, Ixora Kamisan Atan, and Hans Peter Dietz. "Negative urodynamic testing in women with stress incontinence." Australian and New Zealand Journal of Obstetrics and Gynaecology 55, no. 1 (December 12, 2014): 76–80. http://dx.doi.org/10.1111/ajo.12290.

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24

Aldeen, Shayma Mustafa Mohi, Radziah Mohamad, and Safaai Deris. "Automated path testing using the negative selection algorithm." International Journal of Computational Vision and Robotics 7, no. 1/2 (2017): 160. http://dx.doi.org/10.1504/ijcvr.2017.081236.

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Deris, Safaai, Radziah Mohamad, and Shayma Mustafa Mohi Aldeen. "Automated path testing using the negative selection algorithm." International Journal of Computational Vision and Robotics 7, no. 1/2 (2017): 160. http://dx.doi.org/10.1504/ijcvr.2017.10001815.

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26

KATO, Takashi, and Koji TANAKA. "Prevention of the Negative Suggestion Effect in Testing." Proceedings of the Annual Convention of the Japanese Psychological Association 76 (September 11, 2012): 1PMA07. http://dx.doi.org/10.4992/pacjpa.76.0_1pma07.

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27

Hashmi, S., Hector Mendez-Figueroa, Salma Nassef, Blair Stevens, Claire Singletary, and A. Wittman. "Patient Perception of Negative Noninvasive Prenatal Testing Results." American Journal of Perinatology Reports 06, no. 04 (November 28, 2016): e391-e406. http://dx.doi.org/10.1055/s-0036-1594243.

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28

Negri, Giovanni, Bettina Rigo, Fabio Vittadello, Christine Mian, and Eduard Egarter-Vigl. "Abnormal cervicovaginal cytology with negative human papillomavirus testing." Cancer 111, no. 5 (August 27, 2007): 280–84. http://dx.doi.org/10.1002/cncr.22952.

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29

Yomtovian, Roslyn. "HTLV-III Antibody Testing: The False-Negative Rate." JAMA: The Journal of the American Medical Association 255, no. 5 (February 7, 1986): 609. http://dx.doi.org/10.1001/jama.1986.03370050047008.

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30

Yomtovian, R. "HTLV-III antibody testing: the false-negative rate." JAMA: The Journal of the American Medical Association 255, no. 5 (February 7, 1986): 609b—609. http://dx.doi.org/10.1001/jama.255.5.609b.

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31

Tierney, W. M., and C. J. McDonald. "Testing Informatics Innovations: The Value of Negative Trials." Journal of the American Medical Informatics Association 3, no. 5 (September 1, 1996): 358–59. http://dx.doi.org/10.1136/jamia.1996.97035027.

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32

Intons-Peterson, M. J., Paola Rocchi, Tara West, Kimberly McLellan, and Amy Hackney. ""Aging, optimal testing times, and negative priming": Correction." Journal of Experimental Psychology: Learning, Memory, and Cognition 24, no. 4 (1998): 844. http://dx.doi.org/10.1037/0278-7393.24.4.844.

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33

Li, Chin-Shang. "Testing the linearity of negative binomial regression models." Journal of Statistical Computation and Simulation 85, no. 5 (November 25, 2013): 1013–25. http://dx.doi.org/10.1080/00949655.2013.860138.

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34

Ziolkowski, R. W. "Design, fabrication, and testing of double negative metamaterials." IEEE Transactions on Antennas and Propagation 51, no. 7 (July 2003): 1516–29. http://dx.doi.org/10.1109/tap.2003.813622.

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35

Laughlin, Patrick R., Vicki J. Magley, and Ellen I. Shupe. "Positive and Negative Hypothesis Testing by Cooperative Groups." Organizational Behavior and Human Decision Processes 69, no. 3 (March 1997): 265–75. http://dx.doi.org/10.1006/obhd.1997.2687.

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36

Rawson, Katherine A., Kathryn T. Wissman, and Kalif E. Vaughn. "Does testing impair relational processing? Failed attempts to replicate the negative testing effect." Journal of Experimental Psychology: Learning, Memory, and Cognition 41, no. 5 (September 2015): 1326–36. http://dx.doi.org/10.1037/xlm0000127.

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37

Emmerdinger, Kathrin J., Christof Kuhbandner, and Franziska Berchtold. "Testing emotional memories: does negative emotional significance influence the benefit received from testing?" Cognition and Emotion 32, no. 4 (July 31, 2017): 852–59. http://dx.doi.org/10.1080/02699931.2017.1359496.

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38

Larrabee, Yuna C., and William Reisacher. "Intradermal testing after negative skin prick testing for patients with high suspicion of allergy." International Forum of Allergy & Rhinology 5, no. 6 (March 10, 2015): 547–50. http://dx.doi.org/10.1002/alr.21512.

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39

Jarrell, John, and Lars Arendt-Nielsen. "Negative laparoscopy unveiled." Journal of Endometriosis and Pelvic Pain Disorders 10, no. 1 (February 26, 2018): 18–21. http://dx.doi.org/10.1177/2284026517749478.

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Introduction: Studies indicate a variable proportion of laparoscopies done for the management of non-acute pelvic pain that do not identify visible pathology and are called negative laparoscopies. Possible explanations have included undetected endometriosis, observer error, and/or neural tissues in the endometrium acting as nociceptive input. The goal was to compare demographic and pain testing measures between women with negative laparoscopies and confirmed endometriosis in a cohort of women presenting with chronic pelvic pain. Methods: Women with chronic pelvic pain (n = 255) provided written consent for the study prior to entry. Data were collected at the time of clinic visit and entered contemporaneously into SPSS. Pain sensitization was identified as the presence of cutaneous allodynia. Clinical, pain, and pain sensitization variables were compared using Student’s t-test. Results: The frequency of negative laparoscopy was 13.7% (35 cases) and that of confirmed endometriosis was 27.1% (69 cases). There were no differences between women with a negative laparoscopy and women with confirmed endometriosis in clinical, dysmenorrhea, or pain testing measurements. Conclusion: The data suggest in the absence of endometriotic tissue in the pelvis, chronic visceral pain may result from a uterine origin and result in a generalized pattern of pain and pain sensitization.
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40

Butcher, Sophie, Melanie Smith, Ian R. Woodcock, Martin Delatycki, Monique M. Ryan, and Robin Forbes. "False Negative Carrier Screening in Spinal Muscular Atrophy." Journal of Child Neurology 35, no. 4 (December 20, 2019): 274–77. http://dx.doi.org/10.1177/0883073819891269.

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We describe a case of spinal muscular atrophy diagnosed in an infant despite previous parental carrier testing suggesting low risk of the disease. This case report explains how this situation arose and illustrates that clinicians need to perform diagnostic testing in children where clinical suspicion for spinal muscular atrophy is high, regardless of the result of previous parental carrier testing, because of the risk of false negative results.
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Stekler, Joanne, Robert W. Wood, Paul D. Swenson, and Matthew Golden. "Negative Rapid HIV Antibody Testing during Early HIV Infection." Annals of Internal Medicine 147, no. 2 (July 17, 2007): 147. http://dx.doi.org/10.7326/0003-4819-147-2-200707170-00022.

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42

Bhuvaneshwari, G., A. S. Shameembanu, and M. Kalyani. "Disinfectant Susceptibility Testing of Non-Fermenting Gram Negative Bacilli." Research Journal of Pharmacy and Technology 11, no. 4 (2018): 1313. http://dx.doi.org/10.5958/0974-360x.2018.00244.5.

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43

Fenton, W. S., and T. H. McGlashan. "Testing systems for assessment of negative symptoms in schizophrenia." Schizophrenia Research 4, no. 3 (May 1991): 256. http://dx.doi.org/10.1016/0920-9964(91)90106-2.

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44

ELLIOTT, J., D. ABRIL, H. MILLER, K. HALLBAUER, S. COLEMAN, D. JACQUES, and G. STANZIANO. "Pregnancy outcome for women testing negative for fetal fibronectin." Obstetrics & Gynecology 93, no. 4 (April 1999): S40—S41. http://dx.doi.org/10.1016/s0029-7844(99)90086-8.

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45

Kleiman, J., and M. Ben-Shoshan. "Food-dependent exercise-induced anaphylaxis with negative allergy testing." Case Reports 2014, feb06 1 (February 6, 2014): bcr—2013–202057—bcr—2013–202057. http://dx.doi.org/10.1136/bcr-2013-202057.

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46

Roediger, Henry L., and Elizabeth J. Marsh. "The Positive and Negative Consequences of Multiple-Choice Testing." Journal of Experimental Psychology: Learning, Memory, and Cognition 31, no. 5 (2005): 1155–59. http://dx.doi.org/10.1037/0278-7393.31.5.1155.

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47

Landers, John, Katja Ullrich, and Jamie E Craig. "Ibopamine challenge testing becomes negative following successful trabeculectomy surgery." Clinical & Experimental Ophthalmology 44, no. 3 (February 12, 2016): 166–69. http://dx.doi.org/10.1111/ceo.12684.

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48

Sthel, M., J. Rieumont, and R. Martinez. "Testing a furfuryl alcohol resin as a negative photoresist." Polymer Testing 18, no. 1 (February 1999): 47–50. http://dx.doi.org/10.1016/s0142-9418(98)00006-3.

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49

Patel, Vikas J., Michael C. Bruck, and Bruce E. Katz. "Hypersensitivity Reaction to Hyaluronic Acid with Negative Skin Testing." Plastic and Reconstructive Surgery 117, no. 6 (May 2006): 92e—94e. http://dx.doi.org/10.1097/01.prs.0000209926.79944.36.

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50

Mathur, Siddharth, Niket Sonpal, William Thelmo, Mukul Arya, and Yashpal Arya. "An Aggressive MALT Lymphoma Despite Negative Helicobacter pylori Testing." American Journal of Gastroenterology 104 (October 2009): S229. http://dx.doi.org/10.14309/00000434-200910003-00614.

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