Dissertations / Theses on the topic 'Near infrared imaging probes'
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Quartel, John Conrad. "A study of near-field optical imaging using an infrared microscope." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313413.
Full textBordy, Mathieu. "Synthèse et évaluation biologique de sondes fluorogènes pour la détection d’activités enzymatiques." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSEN072.
Full textThis doctoral thesis deals with the design and evaluation of fluorogenic probes for the detection of enzymatic activities in biological contexts of interest.The development of stable fluorogenic probes incorporating ELF-97 is one of the research themes actively pursued by our team. The successful development of peptidases and glycosidases probes have opened many perspectives. A first chapter will be dedicated to the diversification of these probes, firstly by the variation of substrates for the detection of new glycosidases, then by the development of an innovative spacer in the context of cell senescence. In particular, a probe for the detection of β-galactosidase in acidic medium has been synthesized and tested.In parallel, work has focused on a new generation of probes targeting an enzyme family with strong scientific and societal interest : β-lactamases. The synthesis and the preliminary biological evaluation of a first model probe demonstrated the effectiveness of this new molecular architecture. This probe subsequently led to the development of first imaging results as part of an active collaboration with a Japanese research team.Finally, a last part will be devoted to a project whose objective is not recent in the team : the development of alternatives to the ELF-97 presenting a shifted emission towards the red or the near infrared. For this purpose, the synthesis of new fluorophores, their physicochemical characterizations and incorporation tests in responding devices have been carried out. Several candidates have proved to have high potential for two main reasons : strongly red-shifted emission or high insolubility. They could eventually allow the adaptation of the technology to an in vivo use, the ultimate goal of the technology in the context of molecular imaging
Meyer, Yves. "Conception et développement de bras réactifs auto-immolables pour la synthèse de sondes pro-fluorescentes : applications à la détection de peptidases dans un contexte in-vivo." Thesis, Rouen, INSA, 2010. http://www.theses.fr/2010ISAM0018.
Full textThe aim of this PhD work is the design and development of novel self-immolative species linking a peptide susbstrate to a phenolic fluorophore. A first part was dedicated to the development of self-immolative linkers for exopeptidases detection and their incorporation in caspase 3 probes to stain the apoptotic process. A second part was devoted to the extension of the strategy to endopeptidases, especially MMPs, an enzyme family mainly involved in cancer progression
Damin, Craig Anthony. "Instrument Development and Application for Qualitative and Quantitative Sample Analyses Using Infrared and Raman Spectroscopies." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1385774823.
Full textLescure, Robin. "Développement d’azaBODIPYs fonctionnalisables pour la conception de sondes d’imagerie bimodale et d’agents théranostiques." Thesis, Bourgogne Franche-Comté, 2020. https://nuxeo.u-bourgogne.fr/nuxeo/site/esupversions/21e2771a-9c75-46d7-9377-50e8f2536c32.
Full textThe in vivo use of optical imaging is still limited by the lack of near infrared emitting probes. This thesis work focuses on the optimization and valorization of a water-soluble fluorescent platform whose optical properties enable an in vivo use. Two distinct applications were investigated for this WazaBY (Water-soluble azaBODIPY) platform: use as a PET (or SPECT) / optical bimodal probe, and as a theranostic agent. Concerning the first project, we were able to develop a targetted SPECT/optical bimodal probe, which was radiometallated with indium 111. Using xenografted murine models, we were able to show a clear accumulation of the probe in the tumor 24 hours after injection. Moreover, the probe was validated as a contrast agent for fluorescence guided surgery experiment. The second project of this thesis began by the synthesis of a first generation of gold based theranostic agents. The goal was to develop a new therapeutic complex, which can be tracked in vitro and in vivo thanks to optical imaging. In vitro preliminary results showed that the theranostics displayed a cytotoxicity comparable to auranofin on the tested cell lines (4T1, MDA MB 231, CT26 and SW480). A second part of this project focused on the develoment of « smart » probes for a theranostic use. Those probes are designed to undergo photophysical properties changes, when their metallic centre, responsible for the therapeutic role, is released. Two molecules were synthesized, both displaying an on/off behavior
Minchin, Nigel Robert. "Near-infrared imaging polarimetry of bipolar nebulae." Thesis, University of Hertfordshire, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293286.
Full textCheng, Hok Yan. "Near infrared fluorescence probes : towards applications in fluorescence guided surgery." Thesis, University of Hull, 2017. http://hydra.hull.ac.uk/resources/hull:16529.
Full textPackham, Christopher Charles. "Near infrared imaging and polarimetry of active galactic nuclei." Thesis, University of Hertfordshire, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338568.
Full textServati, A. "Nanoparticles for simultaneous near-infrared and magnetic biomolecular imaging." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1367959/.
Full textHouston, Jessica Perea. "Near infrared optical lymphography for cancer diagnostics." Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/4807.
Full textOkoh, Okoh Adeyi. "The synthesis and evaluation of non-targeted near-infrared heptamethine molecular probes." Thesis, University of Central Lancashire, 2013. http://clok.uclan.ac.uk/9232/.
Full textSchoedel, Rainer. "High Resolution Near-Infrared Imaging Observations of the Galactic Centre." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-22565.
Full textKlohs, Jan [Verfasser]. "Near-infrared fluorescence imaging of inflammation in stroke / Jan Klohs." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2008. http://d-nb.info/1023328542/34.
Full textClose, Laird Miller. "High resolution near-infrared imaging with tip-tilt adaptive optics." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187324.
Full textWong, Gerald. "Snapshot hyperspectral imaging : near-infrared image replicating imaging spectrometer and achromatisation of Wollaston prisms." Thesis, Heriot-Watt University, 2012. http://hdl.handle.net/10399/2615.
Full textHan, Xiao. "In vivo near-infrared fluorescence imaging of skin and cutaneous melanin." Thesis, Vancouver : University of British Columbia, 2006. http://hdl.handle.net/2429/77.
Full textFernando, Nilmi T. "Novel Near-Infrared Cyanine Dyes for Fluorescence Imaging in Biological Systems." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/57.
Full textAkin, Ryan E. "Minimally invasive assessment of lymphatic pumping pressure using near infrared imaging." Thesis, Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47536.
Full textSeptember, Danwille Jacqwin Franco. "Detection and quantification of spice adulteration by near infrared hyperspectral imaging." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6624.
Full textENGLISH ABSTRACT: Near infrared hyperspectral imaging (NIR HSI) in conjunction with multivariate image analysis was evaluated for the detection of millet and buckwheat flour in ground black pepper. Additionally, midinfrared (MIR) spectroscopy was used for the quantification of millet and buckwheat flour in ground black pepper. These techniques were applied as they allow non-destructive, invasive and rapid analysis. Black pepper and adulterant (either millet or buckwheat flour) mixtures were made in 5% (w/w) increments spanning the range 0-100% (w/w). The mixtures were transferred to eppendorf tube holders and imaged with a sisuChema short wave infrared (SWIR) pushbroom imaging system across the spectral range of 1000–2498 nm. Principal component analysis (PCA) was applied to pseudo-absorbance images for the removal of unwanted data (e.g. background, shading effects and bad pixels). PCA was subsequently applied to the ‘cleaned’ data. An adulterant concentration related gradient was observed in principal component one (PC1) and a difference between black pepper adulterated with buckwheat and millet was noted in PC4. Four absorption peaks (1461, 2241, 2303 and 2347 nm) were identified in the loading line plot of PC1 that are associated with protein and oil. The loading line plot of PC4 revealed absorption peaks at 1955, 1999, 2136 and 2303 nm, that are related to protein and oil. Partial least squares discriminant analysis (PLS-DA) was applied to NIR HSI images for discrimination between black pepper adulterated with varying amounts of adulterant (millet or buckwheat). The model created with millet adulterated black pepper samples had a classification accuracy of 77%; a classification accuracy of 70% was obtained for the buckwheat adulterated black pepper samples. An average spectrum was calculated for each sample in the NIR HSI images and the resultant spectra were used for the quantification of adulterant (millet or buckwheat) in ground black pepper. All samples were also analysed using an attenuated total reflectance (ATR) Fourier transform (FT) – infrared (IR) instrument and MIR spectra were collected between 576 and 3999 cm-1. PLS regression was employed. NIR based predictions (r2 = 0.99, RMSEP = 3.02% (w/w), PLS factor = 4) were more accurate than MIR based predictions (r2 = 0.56, RMSEP = 19.94% (w/w), PLS factors = 7). Preprocessed NIR spectra revealed adulterant specific absorption bands (1743, 2112 and 2167 nm) whereas preprocessed MIR spectra revealed a buckwheat specific signal at 1574 cm-1. NIR HSI has great promise for both the qualitative and quantitative analysis of powdered food products. Our study signals the beginning of incorporating hyperspectral imaging in the analysis of powdered food substances and results can be improved with advances in instrumental development and better sample preparation.
AFRIKAANSE OPSOMMING: Die gebruik van naby infrarooi hiperspektrale beelding (NIR HB) tesame met veelvoudige beeldanalise is ondersoek vir die opsporing van stysel-verwante produkte (giers en bokwiet) in gemaalde swart pepper. Middel-infrarooi (MIR) spektroskopie is addisioneel gebruik vir die kwantifisering van hierdie stysel-verwante produkte in swart pepper. Albei hierdie tegnieke is toegepas aangesien dit deurdringend van aard is en dit bied nie-destruktiewe sowel as spoedige analise. Swart pepper en vervalsingsmiddel (giers of bokwiet) mengsels is uitgevoer in 5% (m/m) inkremente tussen 0 en 100% (m/m). Eppendorfbuishouers is met die mengsels gevul en hiperspektrale beelde is verkry deur die gebruik van ‘n sisuChema SWIR (kortgolf infrarooi) kamera met ‘n spektrale reikwydte van 1000–2498 nm. Hoofkomponent-analise (HK) is toegepas op pseudo-absorbansie beelde vir die verwydering van ongewenste data (bv. agtergrond, skadu en dooie piksels). Hoofkomponent-analise is vervolgens toegepas op die ‘skoon’ data. Hoofkomponent (HK) een (HK1) het die aanwesigheid van ‘n vervalsingsmiddel konsentrasie verwante gradient getoon terwyl HK4 ‘n verskil getoon het tussen swart pepper vervals met giers en bokwiet. Vier absorpsiepieke (1461, 2241, 2303 en 2347 nm) was geïdentifiseer binne die HK lading stip van HK1 wat met proteïen en olie geassosieer kon word. Die HK lading stip van HK4 het absorpsipieke by 1955, 1999, 2136 en 2303 nm aangedui wat verband hou met proteïen en olie. Parsiële kleinste waarde diskriminant-analise (PKW-DA) is toegepas op die hiperspektrale beelde vir die moontlike onderskeiding tussen swart pepper vervals met verskeie hoeveelhede vervalsingsmiddel (giers of bokwiet). ‘n Klassifikasie koers van 77% is verkry vir die model ontwikkel met giers vervalsde swart pepper terwyl die model ontwikkel met bokwiet vervalsde swarte pepper ‘n klassifikasie koers van 70% bereik het. ‘n Gemiddelde spektrum is bereken vir elke monster in die hiperspektrale beelde en die resulterende spektra is gebruik vir die kwantifisering van vervalsingsmiddels (giers of bokwiet) in gemaalde swart pepper. ‘n ATR FT-IR instrument met spektrale reikwydte van 576-3999 cm-1 is additioneel gebruik vir die analise van alle monsters. Parsiële kleinste waarde regressie is gebruik vir kwantifikasie doeleindes. NIR gebasseerde voorspellings (r2 = 0.99, RMSEP = 3.02% (m/m), PLS faktore = 4) was meer akkuraat as die MIR gebasseerde voorspellings (r2 = 0.56, RMSEP = 19.94% (m/m), PLS faktore = 7). Vooraf behandelde NIR spektra het vervalsingsmiddel verwante absorpsiepieke (1743, 2112 en 2167 nm) aangetoon terwyl vooraf behandelde MIR spektra ‘n bokwiet verwante absorpsiepiek by 1574 cm-1 aangedui het. NIR HB toon goeie potensiaal vir beide kwalitatiewe en kwantitatiewe analise van gepoeierde voedsel produkte. Ons studie kan gesien word as die begin van die inkorporasie van hiperspektrale beelding in die analise van gepoeierde voedsel material en verbeterde resulte kan verkry word deur die vordering in instrumentasie ontwikkeling en verbeterde monstervoorbereiding.
Zou, X. "Illumination invariant face recognition based on active near-infrared differential imaging." Thesis, University of Surrey, 2007. http://epubs.surrey.ac.uk/844079/.
Full textPuvanakrishnan, Priyaveena. "Near-infrared narrow-band imaging of gold/silica nanoshells in tumors." Thesis, [Austin, Tex. : University of Texas, 2009. http://hdl.handle.net/2152/ETD-UT-2009-05-43.
Full textGragg, Jamie Loretta. "Synthesis of Near-Infrared Heptamethine Cyanine Dyes." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/28.
Full textLai, Puxiang. "PHOTOREFRACTIVE CRYSTAL-BASED ACOUSTO-OPTIC IMAGING IN THE NEAR-INFRARED AND ITS APPLICATIONS." Thesis, Boston University, 2010. https://hdl.handle.net/2144/1378.
Full textBernard M. Gordon Center for Subsurface and Imaging Systems (CenSSIS) via the NSF ERC award number EEC-9986821.
Gurfinkel, Mikhail. "Cancer diagnostics using dynamic near-infrared optical imaging and fluorescent contrast agents." Texas A&M University, 2005. http://hdl.handle.net/1969.1/3162.
Full textLaborde, Antoine. "Detection of minor compounds in food powder using near infrared hyperspectral imaging." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASB017.
Full textNear-infrared (NIR) hyperspectral imaging provides a spectral map for organic samples. Minor compounds in food powder can be looked for by analyzing the pixel spectra. However, the NIR spectral analysis is limited to a given depth. Besides, particles smaller than the pixel size induce a mixed spectral signature in the pixels. These two issues are an obstacle to the analysis of minor compounds in food powders.We propose a method to determine the detection depth of a composite target under a layer of powder such as wheat flour. It is based on the Partial Least Squares regression and provides an understanding of how the NIR signal is attenuated when the layer of powder despite the penetration depth issues.Two spectral unmixing strategies are proposed to detect pixel with minor compound NIR signatures. The lack of reference values to validate the model and the ambiguity of the spectral signature to unmix are two major difficulties. The first method models the spectral variability using Principal Component Analysis to design a performant detection algorithm. Then, for a more complex situation, the Multivariate Curve Resolution Alternating Least-Squares algorithm is used to unmix each pixel
Merid, Yonathan. "Study of Cyanine Dye Binding to Amino Acids and Its Analytical Utility." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_theses/27.
Full textHillman, Elizabeth Marjorie Clare. "Experimental and theoretical investigations of near infrared tomographic imaging methods and clinical applications." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268884.
Full textNorouzi, Neil. "Synthesis and application of novel near infrared cyanine dyes and optical imaging agents." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/10002.
Full textCarson, Kathryn Jane. "Contributions towards image reconstruction for functional imaging using time-resolved near-infrared measurements." Thesis, Keele University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240034.
Full textPauff, Steven M. "Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/751.
Full textLangri, Dharminder Singh. "Monitoring Cerebral Functional Response using sCMOS-based High Density Near Infrared Spectroscopic Imaging." Wright State University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wright1558610822306817.
Full textPauff, Steven M. "Advancements in the Synthesis and Application of Near-Infrared Imaging Reagents: A Dissertation." eScholarship@UMMS, 2001. http://escholarship.umassmed.edu/gsbs_diss/751.
Full textSumrain, Shadi. "DETECTION OF POLARIMETRIC SIGNATURES USING HIGH-EFFICIENCY POLARIMETRIC IMAGING TECHNIQUES." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1125081616.
Full textRodigas, Timothy John. "High-Contrast Near-Infrared Studies of Planetary Systems and their Circumstellar Environments." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/306772.
Full textNanyam, Yasasvy. "Hyperspectral Imaging for Nondestructive Measurement of Food Quality." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/theses/334.
Full textConcia, Massimo. "Fluorescence labeled PEI-based gene delivery systems for near infrared imaging in nude mice." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-113095.
Full textMartinić, Ivana. "Novel perspectives in near-infrared optical imaging with lanthanide based molecules, macromolecules and nanomaterials." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2033.
Full textThe near-infrared (NIR) region has a significant importance for optical imaging due to the minimal autofluorescence and reduced light scattering thus allowing for improved signal-to-noise ratio and deeper penetration through tissues. Nowadays, the most commonly used NIR-emitting fluorescent probes rely mainly on organic fluorophores or quantum dots and exhibit drawbacks. Several lanthanide(III) ions (Ln³⁺) possess unique optical properties e.g. sharp emission bands the wavelengths of which have minimal sensitivity to the microenvironment, large differences between excitation and emission wavelengths and strong resistance toward photobleaching. In order to obtain the luminescence of lanthanides, the low absorbances of the free Ln³⁺ have to be overcome by the use of appropriate chromophoric groups functioning as a sensitizing “antenna”. We present here several families of Ln³⁺-based probes: (i) small molecules, in particular monometallic complexes constituted by the TTHA-anthraquinone moiety and Ln³⁺, and polymetallic self-assembled Ln³⁺/Zn²⁺ metallacrowns; (ii) novel nanomaterials based on polystyrene beads with two different loadings, i.e. d-f bimetallic Cr³⁺- Ln³⁺+ complex and hydroxyanthraquinone antennae and Ln³⁺ ; (iii) macromolecular generation-3 polyamidoamine dendrimers functionalized with aza-BODIPY sensitizers at their periphery and encapsulating the luminescent Ln³⁺. The photophysical properties, cytotoxicity and cellular uptake were reported and discussed for each of the presented types of Ln³⁺-based probes. Moreover, these probes were successfully tested for visible and/or NIR in vitro imaging by confocal or epifluorescence microscopy experiments. Finally, the reported Ln³⁺-based probes, due to the number of advantageous properties, represent significant breakthroughs toward the developments of new generations of optical imaging agents
Makein, Lisa Jane. "Correlation of Near-infrared chemical imaging of pharmaceutical dosage forms with their dissolution performance." Thesis, University College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498097.
Full textJones, David Alexander. "Near-infrared spectral imaging as a detection technique for organic materials in porous media." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280479.
Full textMuroga, Shun. "Near-infrared Hyperspectral Imaging of Polymeric Products for Nondestructive Quality Assessment in Polymer Processing." Kyoto University, 2019. http://hdl.handle.net/2433/242473.
Full textWatson, Amy Dawn. "Binding studies of near infrared cyanine dyes with human serum albumin anf poly-l-lysine using optical spectroscopy methods." unrestricted, 2006. http://etd.gsu.edu/theses/available/etd-01042008-154159/.
Full textTitle from file title page. Gabor Patonay, committee chair; Zhen Huang, Alfons Baumstark, committee members. Electronic text (236 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Jan. 28, 2008. Includes bibliographical references.
Hall, David Jonathan. "The development of a near infrared time resolved imaging system and the assessment of the methodology for breast imaging." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243779.
Full textGao, Du Yang. "Engineering of protein-based multifunctional nanoparticles with near-infrared absorption as photoacoustic contrast agents for biological applications." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3953810.
Full textMartí, Aluja Idoia. "Analysis of polymerisation / aggregation processes by nir chemical imaging and ftir spectroscopy." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/125668.
Full textThe overall objective of this thesis is to develop analytical methods based on infrared spectroscopy and chemometric techniques to analyse two different processes that involve a state change from a liquid to a solid. The first studied process is a polymerisation process and it was followed by near-infrared chemical imaging (NIR-CI). The chemometric treatment of the images acquired allowed evidencing a tautomer’s equilibrium of one of the reagents. The second studied process was insulin aggregation. Aggregation process was monitored infrared spectroscopy (IR), and different methods were established which allowed on the one hand the assessment of the effect of antiretroviral drugs on the process; and on the other hand, the influence of biochemical variables on the process.
Zalavadia, Ajaykumar. "A Broadly Tunable Surface Plasmon-Coupled Wavelength Filter for Visible and Near Infrared Hyperspectral Imaging." Cleveland State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=csu1522253688346498.
Full textMushonga, Paul. "Fabrication of type-I indium-based near-infrared emitting quantum dots for biological imaging applications." University of the Western Cape, 2013. http://hdl.handle.net/11394/8271.
Full textSemiconductor nanocrystals or quantum dots (QDs) are fluorescent nanometer-sized particles which have physical dimensions that are smaller than the excitonic Bohr radius, large surface area-to-volume ratios, broad absorption spectra and very large molar extinction coefficients. Biomedical applications of QDs are mainly based on II-VI QDs containing cadmium, such as CdSe/ZnS. These cadmium-based systems are associated with high toxicity due to cadmium. As a result, potential replacements of cadmium-based QDs in biological applications are needed. In this study, InP/ZnSe QDs were synthesized for the first time using a one-pot hot injection method. Furthermore, a growth-doping method was used for silver, cobalt and iron incorporation into the InP core. Water compatibility was achieved through ligand exchange with 3- mercaptopropionic acid. In vitro cytotoxicity and imaging/internalization of the as-prepared MP A-InP/ZnSe and MP A-capped CdTe/ZnS QDs were evaluated. InP/ZnSe QDs were successfully synthesized with ZnSe shell causing a 1.4 times reduction in trap-related emission.
Stein-Merlob, Ashley F. "Nanoparticle-Enhanced Near Infrared Fluorescence Imaging of Atheroma Detects Thrombosis-Prone Plaques Prior to Rupture." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:15821600.
Full textPALUKURU, UDAY P. "Development of Near Infrared Spectral Analysis for Native, Engineered and Degraded Cartilage." Diss., Temple University Libraries, 2014. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/270245.
Full textPh.D.
Articular cartilage helps in the motion of the diarthroidal joints by providing a near frictionless load bearing surface. Identification of changes in articular cartilage chemical and structural properties that arise from degeneration and suboptimal tissue repair have been the target of many studies. Current methods that evaluate these changes frequently involve destructive specimen preparation. Thus there is a need to develop a method to accurately evaluate changes in cartilage during disease or repair processes. Fourier transform infrared (FTIR) spectroscopy in the mid-infrared (MIR) spectral range is based on molecular vibrations and has been used to study the chemical and structural properties of biological tissues, including cartilage. However, this technique generally requires extensive sample preparation and modification of the intact tissue. An alternative approach is to use near-infrared spectroscopy (NIRS) which does not require sample preparation due to higher depth of penetration. This doctoral dissertation focuses on identification of NIR spectral features to evaluate the major components of cartilage. These NIR spectral features are then used to evaluate compositional changes in engineered and degraded cartilage, and the results validated with histological, biochemical, mechanical and MIR analysis of the same tissue. Together, these studies lay the groundwork for clinical and in situ applications of NIRS.
Temple University--Theses
Zhang, Lin. "PATTERN RECOGNITION METHODS FOR THE ANALYSIS OF INFRARED IMAGING DATA AND MULTIVARIATE CALIBRATION STANDARDIZATION FOR NEAR-INFARED SPECTROSCOPY." Ohio : Ohio University, 2002. http://www.ohiolink.edu/etd/view.cgi?ohiou1013445546.
Full textRiseby, Emil, and Alexander Svensson. "Multispectral Imaging for Surveillance Applications." Thesis, Linköpings universitet, Medie- och Informationsteknik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-115731.
Full text