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Journal articles on the topic "NCR Corporation"
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Long, Henery F. "Bank and corporation Taxes in Massachusetts." National Municipal Review 14, no. 8 (January 5, 2007): 470–73. http://dx.doi.org/10.1002/ncr.4110140802.
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Agarwal, Juhi, Chandrakant S. Pandav, Madhukar G. Karmarkar, and Sirimavo Nair. "Community monitoring of the National Iodine Deficiency Disorders Control Programme in the National Capital Region of Delhi." Public Health Nutrition 14, no. 5 (March 1, 2010): 754–57. http://dx.doi.org/10.1017/s1368980010000297.
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AbstractObjectiveThe present study was conducted to assess the current status of iodine-deficiency disorders (IDD) in the National Capital Region of Delhi (NCR Delhi) and evaluate the implementation and impact of the National Iodine Deficiency Disorders Control Programme (NIDDCP).DesignCross-sectional study.SettingSchool-going children (n1230) in the age group of 6–12 years were enrolled from thirty primary schools in the Municipal Corporation of Delhi. Thirty schools were selected using the probability-proportional-to-size cluster sampling methodology. In each identified school forty-one children were surveyed. Urine and salt samples were collected and studied for iodine concentration. A total of sixty salt samples from retail level were also collected.SubjectsSchoolchildren aged 6–12 years.ResultsThe median urinary iodine excretion (UIE) was found to be 198·4 μg/l. The percentage of children with UIE levels of <20·0, 20·0–49·9, 50·0–99·9 and ≥100·0 μg/l was 1·9, 4·3, 9·5 and 84·2 %, respectively. The proportion of households consuming adequately iodized salt (salt with iodine levels of at least 15 ppm at consumption level) was 88·8 %. The assessment of iodine content of salt revealed that only 6·1 % of the families were consuming salt with iodine content less than 7 ppm. At retail level 88·3 % of salt samples had >15 ppm iodine.ConclusionsSignificant progress has been achieved towards elimination of IDD from NCR Delhi. There is a need for further strengthening of the system to monitor the quality of iodized salt provided to the beneficiaries under the universal salt iodization programme and so eliminate IDD from NCR Delhi.
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Gautam, Neeraj. "A Study of Financial Planning on Young Individuals in Delhi NCR." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 05 (May 12, 2024): 1–5. http://dx.doi.org/10.55041/ijsrem33889.
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This research paper investigates the significance of financial planning for young individuals in achieving long-term financial security and stability. With the increasing complexity of the financial landscape and the challenges posed by economic uncertainties, effective financial planning is indispensable for the younger generation. The paper examines various strategies and tools available for young individuals to manage their finances prudently, including budgeting, saving, investing, and debt management. Additionally, it explores the role of financial education and literacy in empowering young people to make informed decisions about their finances. Through a comprehensive review of existing literature and case studies, this paper highlights the importance of early financial planning in building wealth, mitigating risks, and achieving financial goals. Furthermore, it discusses the potential barriers and challenges faced by young individuals in implementing financial plans, such as student loans, low income, and lack of knowledge. Finally, the paper offers practical recommendations and actionable insights for young individuals to enhance their financial well-being and lay a strong foundation for a secure financial future. Monetary items function as a venture route, providing the financial supporters with the predefined monetary security and upholding the monetary items' gamble return profile. In the past traditionally, In India, banks (credit and store accounts), the Life Insurance Corporation (LIC), and the Post Office (repeating shop, National Saving Certificate, Kisan Vikas Patra) all displayed financial products. However, in recent times, as the financial services sector has advanced, new financial products have been introduced, including common stocks, shares, subordinates, annuity plans, children's education plans, life and non-extra security plans (Unit Linked Investment Plans, or ULIPs), common assets, and shares. Each person behaves differently when contributing, therefore each has a different predisposition towards speculation. A private person's investment behavior is influenced by his own circumstances. With the presumption of producing yields people invest in a few financial goods with the hope of earning sizable returns over time and with varying degrees of risk. The goal of the current analysis is to examine how salaried individuals speculate about financial goods that are supported by various segment elements.
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Verma, Rajanikant, and Nisha Bajaj. "COMPARATIVE STUDY ON PRIVATE & PUBLIC SECTOR BANK’S EMPLOYEES OF DELHI -NCR WITH RESPECT TO EUSTRESS MANAGEMENT." Sachetas 1, no. 3 (July 4, 2022): 60–67. http://dx.doi.org/10.55955/130006.
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Usually, the stress symbolises the negative meaning as it is that mental pressure & emotional instability which overpower an individual’s intellectual ability & critical thinking. This impacts their physical & mental health which in turn leads to inefficiency in accomplishment of organisational goals. Here, there is a need to shift in a perception from a negative stress to positive stress. The concept of Eustress becomes important in the present competitive era. It acts as a force that drives & stimulates the employees to fulfil the organisational goals along with their own holistic growth. This is an exploratory study which aims to determine that how public sector & private sector bank employees perceives the circumstances that causes stress and to identify the effect of eustress on job satisfaction & organisational commitment. In this study, the primary data have been collected by using questionnaire method which had given to the employees of four banks in Delhi-NCR named as: State Bank of India (SBI), Punjab National Bank (PNB), Kotak Mahindra Bank, Housing Development Finance Corporation Limited (HDFC) Bank i. e. two each from public sector and private sector banks. In this study, a total of 250 bank employees are as respondents, both from public & private sector banks. The various statistical tools have been used to test the hypothesis. The study concludes that pressure to complete task on time, increase in competence along with conscious efforts to reduce costs; job insecurity and internal competition will encourage the employees to enhance their capabilities & develop necessary skills for promotion & various other incentives.
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San Miguel, Jesús F., Vânia TM Hungria, Sung-Soo Yoon, Meral Beksac, Meletios A. Dimopoulos, Ashraf Elghandour, Wieslaw W. Jedrzejczak, et al. "Analysis of Outcomes Based on Response in Patients with Relapsed or Relapsed and Refractory Multiple Myeloma Treated with Panobinostat or Placebo in Combination with Bortezomib and Dexamethasone in the Panorama 1 Trial: Updated Analysis Based on Prior Treatment." Blood 126, no. 23 (December 3, 2015): 4230. http://dx.doi.org/10.1182/blood.v126.23.4230.4230.
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Abstract Introduction: Panobinostat (PAN), a potent pan-deacetylase inhibitor, was the first agent of its class to produce a statistically significant and clinically meaningful increase in the median progression-free survival (PFS) of patients (pts) with relapsed or relapsed and refractory multiple myeloma (MM) in a phase 3 trial. In the PANORAMA 1 trial, the addition of PAN to treatment with bortezomib (BTZ) and dexamethasone (Dex; PAN-BTZ-Dex) led to a significant increase in high-quality responses (near-complete response/complete response [nCR/CR]; 27.6%) vs treatment with placebo (Pbo), BTZ, and Dex (15.7%; P = .00006). Pts in the PAN-BTZ-Dex arm also had a significantly prolonged median PFS of 12.0 months vs 8.1 months in pts treated with Pbo-BTZ-Dex (hazard ratio [HR], 0.63; P < .0001). Further, subgroup analysis showed that the PFS benefit was maintained in pts with previous exposure to BTZ and immunomodulatory drugs (IMiDs; 10.6 vs 5.8 months; HR, 0.52). These results supported the recent US FDA approval of PAN in combination with BTZ and Dex for the treatment of pts with relapsed or relapsed and refractory MM who have received ≥ 2 prior regimens including BTZ and an IMiD. Here, we present a detailed analysis of the effect of response on clinical outcomes in a subpopulation of PANORAMA 1 pts with prior exposure to BTZ and IMiDs. Methods: Response outcomes were analyzed for the subgroup of PANORAMA 1 pts with prior exposure to BTZ and IMiDs based on modified European Society for Blood and Marrow Transplantation criteria, including nCR/CR and partial response (PR). A landmark analysis at 12, 18, and 24 weeks was performed using a Cox regression model to assess the median PFS in pts who achieved nCR/CR and PR. Results: Among pts with prior exposure to BTZ and IMiDs, the nCR/CR rate was higher in the PAN-BTZ-Dex arm (22.3% [95% CI, 14.4-32.1]) vs the Pbo-BTZ-Dex arm (9.9% [95% CI, 4.2-16.6]). In the PAN-BTZ-Dex arm, the landmark analysis at 12 weeks demonstrated a median PFS of 13.7 months in pts achieving nCR/CR vs 8.1 months in pts achieving PR (HR, 0.34 [95% CI, 0.12-0.96]). Similarly, pts achieving nCR/CR in the Pbo-BTZ-Dex arm had a median PFS of 12.2 vs 7.8 months for pts achieving a PR (HR, 0.74 [95% CI, 0.27-2.01]). Landmark analysis at 18 weeks demonstrated a median PFS of 15.8 months for pts with nCR/CR vs 10.3 months for pts with a PR in the PAN arm (HR, 0.30 [95% CI, 0.12-0.75]) and 14.1 vs 9.0 months (HR, 0.76 [95% CI, 0.29-1.98]) in the Pbo arm for pts with nCR/CR and PR, respectively. The 24 week landmark assessment revealed a median PFS in the PAN arm of 15.8 months for pts with nCR/CR vs 13.7 months for pts with PR (HR, 0.32 [95% CI, 0.14-0.74]) and, in the Pbo arm, a median PFS of 12.2 months for pts with nCR/CR vs 11.2 months in pts with PR (HR, 0.93 [95% CI, 0.36-2.43]). Conclusions: Treatment with PAN-BTZ-Dex is associated with a > 2-fold increase in the rate of nCR/CR in pts with relapsed or relapsed and refractory MM compared with control arm. Among study pts who had received prior treatment with BTZ + IMiDs, those who achieved nCR/CR after treatment with PAN-BTZ-Dex demonstrated a prolonged PFS compared to pts who achieved PR.These data highlight the importance of achieving deep responses with PAN-BTZ-Dex in this subpopulation, suggesting that the achievement of such responses may be linked to improved clinical outcomes. Disclosures San Miguel: Millennium: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees; Onyx: Membership on an entity's Board of Directors or advisory committees; Janssen: Membership on an entity's Board of Directors or advisory committees; BMS: Membership on an entity's Board of Directors or advisory committees; MSD: Membership on an entity's Board of Directors or advisory committees. Beksac:Janssen-Cilag: Consultancy, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Takeda: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Bristol-Myers Squibb: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Amgen: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Consultancy, Speakers Bureau. Dimopoulos:Onyx: Honoraria; Novartis: Honoraria; Amgen: Honoraria; Genesis: Honoraria; Janssen-Cilag: Honoraria; Celgene: Honoraria; Janssen: Honoraria. Jedrzejczak:Pfizer: Membership on an entity's Board of Directors or advisory committees; Roche: Membership on an entity's Board of Directors or advisory committees; Novartis: Membership on an entity's Board of Directors or advisory committees; Celgene: Membership on an entity's Board of Directors or advisory committees; Onconova: Membership on an entity's Board of Directors or advisory committees; Janssen: Membership on an entity's Board of Directors or advisory committees. Siritanaratkul:Pfizer: Research Funding; Roche: Research Funding; Novartis: Research Funding; Janssen-Cilag: Research Funding. Schlossman:Millennium: Consultancy. Hou:Novartis: Membership on an entity's Board of Directors or advisory committees. Moreau:Celgene: Honoraria, Membership on an entity's Board of Directors or advisory committees; Millennium: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; Bristol-Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees; Janssen-Cilag: Honoraria, Membership on an entity's Board of Directors or advisory committees. Lonial:Bristol-Myers Squibb: Consultancy, Research Funding; Celgene: Consultancy, Research Funding; Onyx: Consultancy, Research Funding; Novartis: Consultancy, Research Funding; Millennium: Consultancy, Research Funding; Janssen: Consultancy, Research Funding. Einsele:Janssen: Consultancy, Honoraria, Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Research Funding, Speakers Bureau; Novartis: Consultancy, Honoraria, Research Funding, Speakers Bureau; Amgen/Onyx: Consultancy, Honoraria, Research Funding, Speakers Bureau. Sopala:Novartis Pharma: Employment, Equity Ownership. Bengoudifa:Novartis: Employment. Corrado:Novartis: Employment, Equity Ownership. Binlich:Novartis: Employment. Richardson:Millennium Takeda: Membership on an entity's Board of Directors or advisory committees; Gentium S.p.A.: Membership on an entity's Board of Directors or advisory committees, Research Funding; Jazz Pharmaceuticals: Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees; Celgene Corporation: Membership on an entity's Board of Directors or advisory committees.
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Gómez-Jara Díez, Carlos. "Corporate Culpability as a Limit to the Overcriminalization of Corporate Criminal Liability: The Interplay Between Self-Regulation, Corporate Compliance, and Corporate Citizenship." New Criminal Law Review 14, no. 1 (January 1, 2011): 78–96. http://dx.doi.org/10.1525/nclr.2011.14.1.78.
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This paper argues that there is clear sign of the overcriminalization of corporate conduct in America's criminal law and procedure: regardless of the evidence of a law-abiding behavior by a good corporate citizen, the corporation will be considered guilty if a member of its organization commits a crime within the scope of authority and with the intent to benefit the corporation. The paper explains that corporate culpability may function as a limit to this current overcriminalization as it demands in corporate criminal law what is requested in individual criminal law: that despite the agent's action and intent, the principal has not exercised some kind of due diligence. In turn, if evidence of that corporate due diligence is provided, no court should declare that a corporation is guilty. Such an approach is not only consistent with the basic tenets of criminal law, but it also reflects the different rationale for holding corporations criminally liable in modern society (as opposed to the times in which corporate criminal liability was enacted). A recent example of this overcriminalization tendency was provided by the 2nd Circuit's ruling in the case United States v. Ionia Management S.A., which is briefly discussed at the end of the paper.
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Prabhat, Saumya, and David M. Primo. "Risky business: Do disclosure and shareholder approval of corporate political contributions affect firm performance?" Business and Politics 21, no. 2 (December 27, 2018): 205–39. http://dx.doi.org/10.1017/bap.2018.24.
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AbstractThe role of corporations in the U.S. political process has received increased scrutiny in the wake of the U.S. Supreme Court'sCitizens Uniteddecision, leading to calls for greater regulation. In this paper, we analyze whether policies mandating greater disclosure and shareholder approval of political contributions reduce risk and increase firm value, as proponents of such rules claim. Specifically, we examine the Neill Committee Report (NCR), which led to the passage of the United Kingdom's Political Parties, Elections, and Referendums Act 2000 mandating new disclosure and shareholder approval rules. We find that politically active firms did not benefit from the NCR in the days after its release and suffered a decline in value in the months and years that followed. Politically active firms also suffered an increase in risk, as proxied by stock return volatility, following the release of the NCR. We theorize that these findings are due to the reduced flexibility these rules impose on corporate strategy as well as the potential for these rules to facilitate political activism against corporations.
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Jakubowiak, Andrzej J., Dominik Dytfeld, Sundar Jagannath, David H. Vesole, Tara B. Anderson, Brian K. Nordgren, Kristen Detweiler-Short, et al. "Final Results of a Frontline Phase 1/2 Study of Carfilzomib, Lenalidomide, and Low-Dose Dexamethasone (CRd) in Multiple Myeloma (MM)." Blood 118, no. 21 (November 18, 2011): 631. http://dx.doi.org/10.1182/blood.v118.21.631.631.
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Abstract Abstract 631 Introduction: In relapsed and/or refractory MM, the combination of carfilzomib (CFZ) with lenalidomide (Len), and low-dose dexamethasone (Dex) (CRd) has shown very promising efficacy (78% ≥partial response [PR], 40% ≥very good partial response [VGPR], and 24% CR/nCR) and good tolerability including a low rate of peripheral neuropathy (Wang et al, ASCO, 2011). In a Phase I/II study of newly diagnosed MM, the regimen was well tolerated in the Phase I portion of the study up to a maximum dose of CFZ 36 mg/m2, Len 25 mg, and Dex 40 mg, and very active with 96% ≥PR, 70% ≥VGPR, and 55% CR/nCR (Jakubowiak et al, ASH 2010). The lack of overlapping toxicities has allowed these agents to be used at full doses and for extended periods. Here we report the results for all patients (pts) enrolled in both phases of this first prospective trial of CFZ combination in new MM. Methods: In the initial eight 28-day cycles, pts were treated with CFZ at 20 mg/m2, 27 mg/m2 (Phase I), and 36 mg/m2 (Phase I and II), given IV on days 1, 2, 8, 9, 15 and 16, Len at 25 mg PO (days 1–21), and Dex at 40/20 mg PO weekly (cycles 1–4/5–8). Pts achieving ≥PR could proceed to stem cell collection (SCC) using growth factors alone (protocol recommendation) and autologous stem cell transplant (ASCT) after 4 cycles. Per protocol, ASCT candidates were offered the option to continue CRd treatment after SCC. After 8 cycles, pts received 28-day maintenance cycles of CFZ (days 1, 2, 15, 16), Len days 1–21, and Dex weekly at the doses tolerated at the end of 8 cycles. Responses were assessed by IMWG criteria with the addition of nCR. Results: Enrollment was completed (53 pts): 4 pts at CFZ 20 mg/m2, 13 at CFZ 27 mg/m2 and 36 at CFZ 36 mg/m2 (18 in Phase I and 18 in Phase II). Median age was 59 years (range 35–81; 23 pts ≥65), 60% had ISS stage II/III, and 33% (of 49 with available data) had unfavorable cytogenetics: del 13 or hypodiploidy by metaphase, or t(4;14), t (14;16), del 17p by FISH. As of June 30, 2011, toxicity data (cycles 1–8) were available for 51 pts. Hematologic toxicities were reversible and included Grade (G) 3/4: anemia (18%), neutropenia (12%), and thrombocytopenia (10%). The most common non-hematologic toxicities (all G) were hyperglycemia (76%), hypophosphatemia (61%), and infection (53%). G3/4 non-hematologic AEs included hyperglycemia (24%), DVT/PE while on ASA prophylaxis (10%), infection (6%), and mood alteration (2%). PN was limited to G1/2 sensory (24%). Forty-five pts continue treatment with 22 pts in the maintenance phase. Six pts discontinued treatment: 2 proceeded to ASCT, 1 due to toxicity, and 3 due to events unrelated to treatment or per pt wish. The majority of pts did not require dose modifications, either in the initial (31%) or in the maintenance (25%) phase. After a median of 8 cycles (range 1–20), the best responses per IMWG criteria for 49 response-evaluable pts (all pts who completed 1+ cycle) are shown in the Table. Responses were rapid with 46/49 pts achieving at least PR after 1 cycle, and improved with the duration of treatment reaching 100% ≥PR after 4 cycles and 100% ≥VGPR, 79% CR/nCR after 12 cycles. Responses were deep even at the 2 lower dose levels with the majority of pts at 36 mg/m2 still early in treatment. Responses in pts with unfavorable cytogenetics were similar to response rates in all remaining pts and included a 100% ≥PR in 6 pts with del 17p. Twenty-four pts proceeded to SCC after a median of 5 cycles of CRd (range 4–9); using growth factors only in 23 pts and cyclophosphamide and growth factors in 1 pt, with a median 6.55 × 106 CD34+ cells/kg collected (range 3.75–9.6); all resumed CRd treatment. After a median of 9.5 months of follow-up, only 1 pt has progressed, and all are alive Conclusions: CRd is highly active and well-tolerated allowing the use of full doses for an extended time in newly-diagnosed MM pts with limited need for dose modification. Responses are rapid and improve over time reaching 100% ≥VGPR and early time-to-event data are very encouraging. These results compare favorably to the best frontline regimens in MM. Disclosures: Jakubowiak: Bristol-Myers Squibb: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Onyx Pharmaceuticals: Consultancy, Membership on an entity's Board of Directors or advisory committees; Millennium Pharmaceuticals, Inc.: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Celgene: Consultancy, Honoraria, Speakers Bureau; Ortho Biotech: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Exelixis: Consultancy, Honoraria. Off Label Use: Use of the investigational agent carfilzomib, proteasome inhibitor, in the treatment of relapsed and/or refractory multiple myeloma. Jagannath:Millennium: Honoraria; Celgene: Honoraria; Onyx Pharmaceuticals: Honoraria; Merck: Honoraria; OrthoBiotec.Imedex: Membership on an entity's Board of Directors or advisory committees; Medicom World Wide: Membership on an entity's Board of Directors or advisory committees; Optum Health Education: Membership on an entity's Board of Directors or advisory committees; PER Group: Membership on an entity's Board of Directors or advisory committees. Vesole:Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Millennium: Speakers Bureau. Hussein:Celgene Corporation: Employment. Leveque:Onyx Pharmaceuticals: Employment. Vij:Onyx Pharmaceuticals: Consultancy, Research Funding; Celgene: Research Funding, Speakers Bureau; Millennium: Speakers Bureau.
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Vidal, Avis C., and Bob Komives. "Community development corporations: A national perspective." National Civic Review 78, no. 3 (May 1989): 168–77. http://dx.doi.org/10.1002/ncr.4100780304.
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Jimenez-Zepeda, Victor H., Donna E. Reece, Suzanne Trudel, Christine Chen, Ahmed M. Rabea, and Vishal Kukreti. "Lenalidomide (Revlimid), Bortezomib (Velcade) and Dexamethasone (RVD) for Heavily Pretreated Relapsed or Refractory Multiple Myeloma." Blood 116, no. 21 (November 19, 2010): 5028. http://dx.doi.org/10.1182/blood.v116.21.5028.5028.
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Abstract Abstract 5028 Lenalidomide (len) and bortezomib (btz) are active in multiple myeloma (MM). In preclinical studies, lenalidomide sensitized MM cells to bortezomib and dexamethasone (Mitsiades N, et al). The combination of lenalidomide (Revlimid), bortezomib (velcade), and dexamethasone (RVD) has shown excellent efficacy in relapsed/refractory (rel/ref) multiple myeloma (MM) patients (pts), with an overall response rate (ORR) of 84% and a partial response (PR) rate of 68%, including 21% complete/near complete responses (CR/nCR), median duration of response was 24 weeks in responding patients and median number of cycles was 6 (Anderson KC, et al. ASCO 2009: abstract 8536). The aim of this study is to assess the efficacy and toxicity profile when len is used in combination with btz and dexamethasone (dex) for pts with relapsed/refractory (rel/ref) disease outside the setting of clinical trials. Patients and Methods We retrospectively reviewed the records of all pts with rel/ref MM who were treated with RVD at Princess Margaret Hospital between March 2009 and March 2010. Eighteen pts were treated with at least 1 full cycle of RVD therapy given as len 10 mg/d on days 1–14, btz 1.0 or 1.3 mg/m2 on days 1, 4, 8, and 11 of 21-day cycles and dex (20 mg or 40 mg on days of and after btz). Pts routinely received concomitant antithrombotic and antiviral prophylaxis. Primary endpoints were response rate, time to progression (TTP) and toxicity. Responses were assessed according to modified EBMT and Uniform criteria. Toxicity was assessed using NCI-CTC, version 3.0. Results Clinical characteristics are seen in Table 1. Median age was 57 (37-71) years; 55% were female. The median number of prior therapies was 3 (2-6), and the majority of pts had already been treated with len (83%) and btz (78%) separately, and 77% had received both drugs previously but not in combination. In many instances, pts previously treated with len had len added to btz + dex at progression (n=5), or pts previously treated with btz had btz added to len + dex, at progression (n=4). After a median of 4.9 cycles (range 1–14), PR was observed in 7 (39%) and stable disease (SD) in 2 (11%) pts, for an ORR of 39%. Disease progression was seen in 14 pts at a median TTP of 4 months (1-13.6 months). Currently, 6 pts (33%) remain alive at a median F/U of 6.83 months (1.4-18.6 months). Median overall survival was 6.88 months (1-18.6 months) and six patients had a greater than 6 month response. Six pts have experienced grade 3/4 adverse events, including anemia, neutropenia, muscle weakness, hyperglycemia, and pneumonia. No deep vein thrombosis was observed. The side effect profile was manageable; importantly no patient experienced worsening of peripheral neuropathy. Conclusions The ORR for our heavily treated patient population was 39% which is lower than that reported by Anderson et al (ASCO, 2009). The median TTP was also short at 4 months. These differences can be partly explained by the fact the majority of our pts had previously received all the agents in RVD, while only 8% of the pts in the Anderson series had prior len exposure. These data suggest that the RVD combination can be effective in rel/ref MM, but responses/duration are affected by very advanced disease stage at relapse and the extent of prior treatment. Disclosures: Reece: Celgene: Honoraria, Research Funding. Chen:Celgene Corporation: Consultancy, Honoraria, Research Funding. Kukreti:Celgene: Honoraria.
Dissertations / Theses on the topic "NCR Corporation"
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Birnie, Steven James. "Local and global explorations through design research." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/1788c181-878d-4f5b-9de7-2ad099a68e52.
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This doctoral thesis is a practice-led and corporate-grounded enquiry into the role of design research methods in a global technology company. The work aims to understand and communicate through a series of case studies how locally conducted participatory action research can be integrated into the processes of an in-house design team at the global NCR Corporation. It questions the current approaches taken in the design and development of consumer transaction technologies in the context of a global organisation and new markets. The thesis starts by introducing the reader to the global corporation in which the study is focused and author employed, the NCR Corporation. The contextual grounding of the corporate environment, its heritage, history and continued evolution will illustrate the dynamic yet traditional role design has played within the corporation. As a senior member of the Consumer Experience Design (Cx Design) team in the corporation the author is well placed to evaluate the role of design and how it can evolve. The immediate contextualisation is then followed by a broad examination of the literature in the field of design in a corporate culture, research methods and socially-led innovation. This will define the boundaries of interest and influence in the thesis. A participatory action research approach was taken to address the research questions. Informed by a series of hyperlocal and global community engagements framed and directed from within the corporate culture, the author defines an understanding of the levels of community engagement through design research. The resulting outputs are then applied within the context of the NCR Corporation where the impact and influence on such engagements can be understood. The author concludes that his contribution to new knowledge, the development of a Participatory Action Based Strategic Design Process, can be applied within a global technology company. The process adapts McNiff’s and Whitehead’s (2011) seven phases of action research reporting and Ravi Chhatpar’s strategic decision-making process. The thesis demonstrates the value and influence of design research methods in the design of consumer transaction technologies. The thesis provides an understanding of how design research methods have been applied in a corporate environment, how the insights are applied, and demonstrates how the research has influenced the author’s practice and therefore the wider Cx Design group.
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"Strategic adequacy analysis of the organizational performance measurement system in the corporations: a case study in telemar norte leste s.a. - unidade de negócios empresariais da telemar." Tese, MAXWELL, 2004. http://www.maxwell.lambda.ele.puc-rio.br/cgi-bin/db2www/PRG_0991.D2W/SHOW?Cont=6256:pt&Mat=&Sys=&Nr=&Fun=&CdLinPrg=pt.
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Cournier, Marine. "Sociétés minières canadiennes et violations des droits de l’homme à l’étranger : le Canada respecte-t-il les prescriptions internationales en la matière?" Thèse, 2013. http://hdl.handle.net/1866/10446.
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La présente étude a pour objectif de vérifier si le Canada respecte les prescriptions internationales en matière de droits de l’homme et d’entreprises vis-à-vis de l’encadrement qu’il exerce sur les sociétés minières canadiennes évoluant à l’étranger.
En 2011, le Conseil des droits de l’homme de l’ONU a adopté des «Principes directeurs» afin de mettre en oeuvre le cadre de référence « Protéger, Respecter, Réparer » du Représentant spécial chargé de la question des droits de l’homme et des sociétés transnationales et autres entreprises. Selon ce cadre de référence, les États ont des obligations de protection et de réparation alors que les entreprises ont seulement la responsabilité de respecter les droits humains. Après six années de travail, le Représentant spécial John Ruggie, a fait le choix de formuler dans ses «Principes directeurs» des directives non contraignantes à l’égard des États et des entreprises afin de les aider à remplir leurs obligations et responsabilités vis-à-vis des droits de l’homme. Selon, l’ONU, cet instrument de portée universelle est le plus élaboré en la matière, si bien qu’il est recommandé aux entreprises et plus particulièrement aux États de s’y conformer lors de l’élaboration de leurs politiques respectives en
matière d'activité économique et de droits humains.
Il convient donc de vérifier d’une part si l’encadrement exercé par l’appareil législatif et
gouvernemental vis-à-vis des sociétés minières canadiennes évoluant à l’étranger est conforme au principe directeur «Protéger». D’autres part, il convient de vérifier si les recours judiciaires et extrajudiciaires disponibles au Canada remplissent les exigences du principe directeur «Réparer». Cette double analyse permettra de conclure que le Canada respecte dans les grandes lignes ces «Principes directeurs» mais qu’il pourrait faire bien plus notamment en terme d’accès à des réparations effectives pour les victimes étrangères de minières canadiennes.This study propose to assess whether Canada meets the international requirements of business and human rights in relation to the supervision it has on Canadian mining companies operating abroad. In 2011, the Human rights Council adopted the Special Representative’s Guiding Principles on Business and Human Rights in order to implement the United Nations “Protect, Respect and Remedy” Framework. According to this framework, States have obligations to protect and remedy while companies only have responsibilities to respect human rights. After six years of work, the Special Representative on Business and Human rights, John Ruggie, has chosen to give in its Guiding Principles non- binding recommendations in order to help States and businesses to encounter their obligations and responsibilities towards human rights. According to the UN, this universal instrument is the most developed in the field. Thus, it is strongly recommended that companies and especially States, comply those «guiding principles» when they elaborate their respective policies on economic activity and human rights. It is therefore necessary to check first if the supervision exercised by the legislature and the government on Canadian mining companies operating abroad succeeds to comply with the "Protect" principles. On the other hand, it must be checked whether the judicial and extrajudicial remedies available in Canada meet the requirements of the «Remedy" principles. This dual analysis will led to conclude that Canada meets broadly the "Guiding Principles" but could do much more, especially in terms of access to effective remedies for foreign victims of Canadian mining companies.
Books on the topic "NCR Corporation"
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John, Siegel, and Object Management Group, eds. Common object services specification: AT&T/NCR, BNR Europe Limited, Digital Equipment Corporation ... New York: Wiley, 1994.
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Cortada, James W. Before the computer: IBM, NCR, Burroughs, and Remington Rand and the industry they created, 1865-1956. Princeton, N.J: Princeton University Press, 2000.
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Cortada, James W. Before the computer: IBM, NCR, Burroughs, and Remington Rand and the industry they created, 1865-1956. Princeton, N.J: Princeton University Press, 2000.
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Șandru, Daniel-Mihai. Pacte societare: Clauze, pacte, înțelegeri între asociații societăților comerciale în reglementarea NCC. București: Editura Universitară, 2012.
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Williams, Huw. Evolution of NCR Corporation Hospitality Systems. SIHE, 1992.
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Gup, Benton E. Too Big to Fail. Greenwood Publishing Group, Inc., 2003. http://dx.doi.org/10.5040/9798216026426.
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Usually associated with large bank failures, the phrase too big to fail, which is a particular form of government bailout, actually applies to a wide range of industries, as this volume makes clear. Examples range from Chrysler to Lockheed Aircraft and from New York City to Penn Central Railroad. Generally speaking, when a corporation, an organization, or an industry sector is considered by the government to be too important to the overall health of the economy, it will not be allowed to fail. Government bailouts are not new, nor are they limited to the United States. This book presents the views of academics, practitioners, and regulators from around the world (e.g., Australia, Hungary, Japan, Europe, and Latin America) on the implications and consequences of government bailouts.
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Singer, Abraham A. The Concept of Norm-Governed Productivity. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190698348.003.0008.
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The chapter subjects the Chicago school to critique. It starts by reviewing the different views of Coasian thought that were reviewed in Part I. This chapter offers a third approach, which brings Coase’s overlooked views about moral psychology to bear on the question of the corporation. In this view, it is the cultivation of cooperative social norms, not the contractual allocation of governing rights, that allows firms to economize on market failures. This idea is referred to as “norm-governed productivity.” According to this view, firms are not “privately owned markets,” nor do they merely alter people’s decision-making through coercion or incentives; instead, firms work by altering preferences in order to foster cooperative relationships. This conception of corporate efficiency invites the moral question as to whether the relationships being cultivated are good or bad, a question that cannot be short-circuited by the economist’s recourse to choice and preference.
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van, José. Epilogue. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190889760.003.0009.
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The epilogue sketches a few scenarios on potential geopolitical consequences of the global paradigm shift toward multiple online platform “spheres.” Currently, the neoliberal US-based platform ecosystem dominates. This ecosystem revolves around the promotion of individualism and minimal state interference, leaving checks and balances to the market. On the other end of the ideological spectrum is the Chinese ecosystem, in which the autocratic regime controls the platform ecosystem via regulated censorship of tech corporations. Squeezed between the US and the Chinese models is the European Union, whose member states neither own nor operate any major platforms in either ecosystem. For European democracies to survive in the information age, its cities, national governments, and supranational legislature need to collaborate on a blueprint for a common digital strategy toward markets and public sectors.
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Christopher, Symes. 1 National Report for Australia. Oxford University Press, 2016. http://dx.doi.org/10.1093/law/9780198727293.003.0001.
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This chapter discusses the law on creditor claims in Australia. For corporate insolvency and corporate rescue, creditor claims are dealt with by the Corporations Act 2001 (Cth), predominantly in ss 553 to 554J and 555 to 564. For personal bankruptcy, creditor claims are covered by the Bankruptcy Act 1966 (Cth), sections 82 to 104. Australian law traditionally does not distinguish between foreign claims and local claims, nor does it treat the rights of foreign creditors any differently from those of local creditors. The remainder of the chapter presents sections that deal with insolvency claims, administration claims, and non-enforceable claims, arising from bankruptcy, liquidation, and voluntary administration. Each section covers: the definition and scope of the claim; rules for submission, verification, and admission or satisfaction of claims; ranking of claims; and voting and other participation rights in insolvency proceedings.
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Riley, Sam, ed. Star Struck. ABC-CLIO, LLC, 2009. http://dx.doi.org/10.5040/9798216018322.
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This balanced examination looks at America's pervasive celebrity culture, concentrating on the period from 1950 to the present day. Star Struck: An Encyclopedia of Celebrity Culture is neither a stern critic nor an apologist for celebrity infatuation, a phenomenon that sometimes supplants more weighty matters yet constitutes one of our nation's biggest exports. This encyclopedia covers American celebrity culture from 1950 to 2008, examining its various aspects—and its impact—through 86 entries by 30 expert contributors. Demonstrating that all celebrities are famous, but not all famous people are celebrities, the book cuts across the various entertainment medias and their legions of individual "stars." It looks at sports celebrities and examines the role of celebrity in more serious pursuits and institutions such as the news media, corporations, politics, the arts, medicine, and the law. Also included are entries devoted to such topics as paranoia and celebrity, one-name celebrities, celebrity nicknames, family unit celebrity, sidekick celebrities, and even criminal celebrities.
Book chapters on the topic "NCR Corporation"
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de la Torre, Carlos. "Afro-Ecuadorian Responses to Racism: Between Citizenship and Corporatism." In Neither Enemies nor Friends, 61–74. New York: Palgrave Macmillan US, 2005. http://dx.doi.org/10.1057/9781403982636_3.
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Mukhopadhyay, Uttam, Larry M. Stephens, Michael N. Huhns, and Ronald D. Bonnell. "An Intelligent System for Document Retrieval in Distributed Office Environments**This research was supported in part by NCR Corporation." In Readings in Distributed Artificial Intelligence, 565–77. Elsevier, 1988. http://dx.doi.org/10.1016/b978-0-934613-63-7.50057-7.
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Dharia, Namita Vijay. "Artefacts and Artifices of the Global." In Mapping the Elite, 139–61. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780199491070.003.0005.
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The real estate crash in the Global North in 2008, accompanied by the growth of a comparatively stable real estate market in India, saw a number of architects and allied companies from the Global North enter India’s National Capital Region (NCR). Indian state actors and developers, as well as corporations from the Global North, propagated a discourse of the global in order to generate economic and cultural capital for their work. The discourse operated through and embedded into the built environment and material landscapes of NCR. This paper argues that elite cultures in India need to be understood as an entanglement of local governing and corporate elite with foreign elite actors. It further argues that material environments act as sites through which both local and international groups contest, claim, and reframe the elite identities in India, intimately tying together the global and the elite. Material worlds are integral to understanding the dynamics of elite interactions in the Global North and Global South as they cross language barriers, disseminate knowledge sensorially, and constitute the foci of multinational capitalist intervention in developing countries. This paper is part of a cross-class ethnography of the building construction industry in NCR.
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Mayernik, Matthew S. "Toward stronger coupling between technical infrastructures and institutional processes in data-intensive science." In Recent Advancement in Geoinformatics and Data Science. Geological Society of America, 2023. http://dx.doi.org/10.1130/2022.2558(04).
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ABSTRACT The techniques and approaches within geoinformatics and data science rely on the effective coupling of supporting infrastructures and institutions. Without underlying infrastructures for data discovery, analysis, management, distribution, and preservation, new computational techniques wither on the vine for lack of input or remain isolated as niche tools that miss broader potential audiences. Likewise, without supporting institutions that enable governance of policies and finances, coordination of stakeholders, and validation of new knowledge and tools, technological advances become detached from the people and organizations that operate and use them. This paper centers on a case study of work within the National Center for Atmospheric Research (NCAR) and University Corporation for Atmospheric Research (UCAR) to develop effective systems and processes for research data curation, access, discovery, and preservation. By emphasizing iterative alignment of institutional work (policies, intermediaries, governance processes, routines, and financial instruments) and infrastructural work (data storage systems, repositories, tools, and interfaces), balanced progress has been made toward developing solutions to gaps in organizational data services.
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Arlikatti, Sudha, James Kendra, and Eliot Jennings. "Corporate Social Responsibility in Enhancing Disaster Education." In Corporate Social Responsibility, 422–34. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-6192-7.ch023.
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Today, university educators are confronting unparalleled challenges regarding declining state education budgets. Meanwhile, an ethos of corporate social responsibility has taken hold in some sectors, where companies define themselves as members and participants in a community, able to offer something besides financial transactions. Engagement and support of educational programs and institutions is an example of one such kind of involvement. This chapter details such collaborations between Grainger corporation, NC4, ESi Acquisition Inc. and the University of North Texas's Emergency Administration and Planning program. The generosity of these private companies helped the program open an Emergency Operations Center training lab on campus to facilitate hands-on decision support systems training, and enhance creativity and problem solving skills in a simulated environment for emergency management students. Such public-private partnerships and outreach efforts to enhance disaster management training and educational experiences of students have the potential to make a real and lasting difference to all players involved.
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Labonté, Ronald, and Arne Ruckert. "The global diffusion of non-communicable diseases." In Health Equity in a Globalizing Era, 241–66. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198835356.003.0011.
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Notwithstanding the threat of infectious pandemics, non-communicable diseases (NCDs) are now the leading cause of preventable mortality and morbidity in all regions of the world except Africa. The rise in NCDs, especially in the developing world, is very much a result of global market integration, trade and investment liberalization, and the growth in the reach and power of transnational corporations whose stock-in-trade are health-harmful commodities (tobacco, alcohol, and obesogenic foods). The modern global governance challenge of what are now referred to as the ‘commercial determinants of health’ is the extent to which such commodities are regulated by governments, passed over to corporate social (self-) responsibility, or seen as an amalgam of the poor lifestyles of individuals in need of a behavioural ‘nudge’. The World Health Organization, the lead international organization developing responses to the NCD threat, must confront powerful member nations representing powerful corporate interests resistant to regulatory change.
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Lee, Maria R. "The Perspectives of Message-Based Service in Taiwan." In Encyclopedia of Multimedia Technology and Networking, Second Edition, 1148–53. IGI Global, 2009. http://dx.doi.org/10.4018/978-1-60566-014-1.ch156.
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The number of cellular phone subscribers has reached a total of 5.6 million in Taiwan (NCC, 2007). Meanwhile, Internet users have reached a total of 14.5 million and mobile Internet users have broken the record of 9.1 million in 2006 (NCC, 2007). The combination of information and telecommunication technologies has brought people a new communication method—cellular value-added services, which have become a lucrative business for telecommunication providers in Taiwan. One result of the cellular value-added services presented to the public brought the information-based, messaging-based, and financial services into one kit; people can not only communicate through the cellular phones but also use them as versatile handsets. Do- CoMo, a famous Japanese telecommunication provider, has successfully cultivated the cellular value-added services. Its success can be explained with two reasons: one is content, and Web site providers are willing to share their technical support; and the other reason is the establishment of an automated payment system to assist the cash flow between providers and even beef up the whole industry by associating related business partners (Natsuno, 2001). Comparing with DoCoMo’s case, the telecommunication service providers in Taiwan have provided various cellular value-added services. However, the popularity of the service does not turn out to be as good as expected. We are wondering why. Telecommunication providers began to adjust the fee of short message service (SMS) down to 25% maximally since June 2004 in Taiwan. The idea of lowering fees is to stimulate the popularity of SMS usage. Would that bring a collateral effect to the providers of cellular value-added service positively or negatively? In response, this research will discuss the challenges facing Taiwanese cellular value-added service providers. Hinet, Taiwan Cellular Corporation (TCC), and Flyma online service providers have been chosen as research companies.
Conference papers on the topic "NCR Corporation"
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Babilon, Maria. "The evolution of knowledge management with NCR Corporation." In the 16th annual international conference. New York, New York, USA: ACM Press, 1998. http://dx.doi.org/10.1145/296336.296337.
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Knight, Gordon R. "Near Field Recording Technology." In Optical Data Storage. Washington, D.C.: Optica Publishing Group, 1998. http://dx.doi.org/10.1364/ods.1998.wa.1.
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TeraStor Corporation has developed a new recording system based upon Near Field Recording technology using a Solid Immersion Lens in a flying optical head. Aspects of this NFR technology will be discussed along with experimental results.
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Mittal, Ketan, and Miles Greiner. "Thermal Analysis of a NAC-LWT Cask Under Normal and Fire Accident Conditions." In ASME 2012 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/pvp2012-78882.
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Two and three dimensional thermal models of a Nuclear Assurance Corporation Legal Weight Truck (NAC-LWT) cask were constructed using the PATRAN commercial finite element package. The two-dimensional model included the effect of radial stiffeners in the package’s external neutron shield but three-dimensional model did not. A normal conditions of transport (NCT) simulation using both models predicted the peak cladding temperature was roughly 210°C. The NCT package temperatures were used as initial conditions for transient fire/post-fire simulations. Different assumptions were used to determine when the neutron shield liquid drained from the tank and was replaced by air. When the liquid was assumed to remain within the tank during and after the fire, the peak cladding temperature was predicted to exhibit a temporal maximum of roughly 300°C, approximately 6 hours after the end of the fire. If the liquid drained from the tank during the fire, the cladding temperature did not exhibit a temporal peak. Rather, it eventually reached a maximum temperature of roughly 280°C, which is the steady state NCT peak temperature when air is in the neutron shield tank. This undergraduate project will be used to lay down a foundation for further research on NAC-LWT casks. Two and three dimension package of the cask will be constructed using ANSYS, and simulations will be run for NCT and fire/post-fire conditions. The models will also be linked to Container Analysis Fire Environment (CAFE) to predict response of the package in fire.
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Samara, Haya, and Lily OHara. "Nurses’ Knowledge and Attitudes about Adult Post-operative Pain Assessment and Management: A Cross-Sectional Study in Qatar." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0101.
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Background: Pain has been described by clinicians, patients, and researchers alike as a complex and challenging phenomenon. People have different experiences of pain. Nurses’ negative attitudes and lack of knowledge are major impediments to effective pain management. Methods: The study was a cross-sectional online survey using a validated self-administered questionnaire for post-operative registered nurses working in Hamad Medical Corporation in Qatar. The dependent outcome was the score on the Knowledge and Attitudes Survey Regarding Pain. Results: A total of 151 post-operative nurses participated in the study. The mean knowledge and attitudes (K&A) score was 19.6 (SD 4.5) out of 41 (48%), indicating a huge deficit in the nurses’ knowledge and attitudes about adult post-operative pain. No sociodemographic variables were associated with K&A scores. Neither the facility the nurses worked at nor hours of previous pain education were associated with K&A scores. Conclusions: There is a significant deficit in post-operative nurses’ knowledge and attitudes about pain in Hamad Medical Corporation, with no significant differences based on demographics or other characteristics. This suggests the deficit is widespread within the nursing workforce in Qatar. This deficit is potentially impacting significantly on pain assessment and management for adults in post-operative settings. Pragmatic research on evidence-based nursing educational courses focused on pain assessment and management is required to enhance nurses’ knowledge and attitudes and improve patient care. Key messages: Strategies to strengthen nurses’ knowledge and attitudes toward pain in Qatar must be developed and tested.
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Murphy, Ryan. "A Review of In-situ Temperature Measurements for Additive Manufacturing Technologies." In NCSL International Workshop & Symposium. NCSL International, 2016. http://dx.doi.org/10.51843/wsproceedings.2016.11.
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Additive manufacturing (AM) encompasses a rapidly advancing host of technologies used for building parts with complex geometrical shapes layer-by-layer from a wide range of materials such as polymers, glasses, ceramics, metals, and metal-alloys. A wide variety of AM processes are used to build parts on test beds using processes such as material extrusion and laser or e-beam irradiation of powders and liquids, depending on the industrial or commercial application. Unfortunately the dimensional and compositional quality of AM built parts highly depends on the technology, and can even significantly vary between different AM machines of the same technology, due to a lack of process feedback and control. Improvements have been made by performing computational modeling and ex-situ characterization such as x-ray diffraction, focused ion beam cross-sectioning, x-ray computed tomography, and electron microscopy. These techniques, however, are time consuming, expensive, and do not allow in-situ monitoring of parts as they are built. In-situ temperature measurements are promising as they monitor the build temperature and can provide feedback for better process control. Thermal imaging is widely-used for in-situ temperature measurements, but is limited to qualitative data due to the unpredictability of emissivity as temperature and composition dynamically change. Two-color pyrometry and mm-wave radiometry measurements promise to circumvent these problems but have their own dimensional limitations. These methods and others will be compared and contrasted, and future improvements of in-situ temperature measurements will also be discussed. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the US Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. Certain commercial equipment, instruments, or materials are identified in this paper in order to adequately describe the experimental procedure. Such identification does not imply recommendation or endorsement by the authors, Sandia National Laboratories, or NCSL International, nor does it imply that the materials or equipment identified are the only or best available for the purpose.
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Diaz-Elsayed, Nancy, Luis Hernandez, Ravi Rajamani, and Brian A. Weiss. "Asset Condition Management: A Framework for Smart, Health-Ready Manufacturing Systems." In ASME 2020 15th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/msec2020-8326.
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Abstract Unscheduled downtime in manufacturing systems can be a major source of lost productivity, profits, and, ultimately, reduced process quality and reliability. However, the incorporation of asset condition management (ACM) into manufacturing systems offers an approach to improve equipment and plant operations by providing real-time condition awareness, system diagnostics, and estimates of future health to enable predictive maintenance. ACM is a framework for assessing the current and future state of health of a manufacturing system and integrating that knowledge with enterprise applications to meet the demand of production operations. In manufacturing systems, successful operations rely on the ability to maintain production assets at their optimal working levels to optimize operations and system performance. Some large corporations have made great strides in incorporating smart technologies to enhance their asset management strategy; however, small- and medium-sized enterprises (SMEs) face distinct challenges. One of the key challenges is that most SMEs do not have the wherewithal to invest in new machines nor is there standard guidance on how older machines can be integrated into an ACM solution, so that their end-to-end manufacturing process can be optimized from a health management point of view. This research presents a framework for ACM to facilitate its introduction into manufacturing systems based on their “health-ready” capabilities. Specifically, an ACM system architecture is defined for manufacturing systems, the health-ready principles and capability levels from the aerospace and automotive industries are adapted to the manufacturing domain, and the results from the outreach effort to the manufacturing community are discussed.
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Jackson, Craig M. "A DEFINITION OF HEPARIN ANTICOAGULANT POTENCY APPLICABLE TO ALL HEPARINS AND HEPARIN-LIKE SUBSTANCES AND ITS PRACTICAL APPLICATION IN ASSAYING HEPARIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642928.
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Heparins increase the rate of inactivation of proteinases by antithrombin without being consumed in the inactivation reaction. The anticoagulant activity of any heparin or heparin preparation is thus determined by the increase in the inactivaton rate which it produces. This rate increase is dependent on the concentration of the heparin in the sample and on some now well known structural properties of the individual heparin molecules that produce high affinity for antithrombin . All proteinases are not inactivated by antithrombin equally rapidly in the absence of heparin, nor are heparins and heparin derivatives of different molecular weight equally effective in the inactivation of the same proteinase. Under appropriate conditions, the observed rate constant (kObs) for the heparin catalyzed proteinase inactivation reaction is simply related to the intrinsic potencies and concentrations of the individual high affinity heparin molecules in the sample. The intrinsic potency of a high affinity heparin molecule is the efficiency with which it catalyzes the inactivation of the particular proteinase, e.g. Factor Xa or thrombin, i.e., it is a second order rate constant, (designated k*) . After k* has been determined from kobs for a known heparin or heparin preparation and a particular proteinase, the concentration of heparin in an unknown sample can be calculated from the equation[H] = [HAT] = kobs/k* In general terms, the appropriate conditions, i.e.,the antithrombin and proteinase concentrations, the pH, and ionic strength, required for this equation to be used are those conditions for which all of the high affinity heparin is bound to the antithrombin and pseudo first order kinetic behavior occurs. At very low heparin concentrations, a correction for the inactivation of the proteinase by antithrombin alone is necessary, but is easily made.Supported by Organon Teknika Corporation and an Established Investigator Award from the American National Red Cross
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GENNARI, Roseli Fernandes, Gilson GOVEIA, and José Fernando Diniz CHUBACI. "BIOPOLYMERS AS DOSIMETERS - A PROPOSAL." In SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 2021 INTERNATIONAL VIRTUAL CONFERENCE. DR. D. SCIENTIFIC CONSULTING, 2022. http://dx.doi.org/10.48141/sbjchem.21scon.42_abstract_gennari.pdf.
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The radiation study has led to advances in various areas of our everyday lives despite that several events had occurred, causing health damage to several researchers. Thus, if somebody wants to study irradiation effects on materials must use equipment that quantifies the radiation received. Dosimeters do this quantification of ionizing radiation. There are numerous applications for ionizing radiation so far, and many materials can be used for dosimetric purposes. Despite that, there is always a constant search for new materials, focusing on more efficient processes or less environmental impact. For dosimetric purposes, the material has to be radiation sensitive. Many materials have been the subject of research recently, aiming to be environment friendly: among them, we can mention biopolymers that have the great advantage of being biodegradable. A commercial solid-state dosimeter uses silver-activated phosphate glass for radiophotoluminescence (RPL) purposes. This dosimeter has an enormous advantage since it does not lose the dose information after dose reading. It can be reread many times until annealing is done to reset the exposure condition. It can be reused several times. This dosimeter is commercially available as “GD-450” (Chiyoda Technol Corporation). Our research group successfully proposed using silicate glass instead of phosphate glass as RPL dosimeters. Face to the need for a high-temperature furnace for glass sintering, and it was decided to test biopolymers as RPL dosimeters. Once our goal was to have a regenerative dosimeter, we used silver as a sensible radiation element. This work it was synthesized two biopolymers with and without adding silver to them. The biopolymers synthesized used starch and collagen as polymer base material. The biopolymers analysis was done by microscopy and by optical spectrometry (UV-Vis-NIR). We observed irradiation effects on absorption bands from biopolymer of collagen doped with silver.
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Hoy, Chanbormey, Varene Huy, Techchung Khou, Sokanha Mao, and Pichmoninea Sophea. "The Impact of COVID-19 on the Garment Sector in Cambodia." In International Research Symposium on How did a Health Crisis Translate to an Economic Crisis? The Impact of the COVID-19 Pandemic. ALLIED PUBLISHERS PVT. LTD., 2021. http://dx.doi.org/10.62458/camed/oar/symposium/2021/67-76.
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INTRODUCTION As of 2020, business plans, studying, traveling, working-life have been completely ruined by an infectious disease called “COVID-19” which took their first spotlight in Wuhan, China. Since it is a disease that could heavily infect the lungs, it can spread more easily and much worse and faster than expected. Consequently, many schools, restaurants, movie theaters, and other public places have been closed. With fear and concern, people have to practice social distancing, washing their hands, wearing masks, and avoiding the crowds. In the worst-case scenario, some cities were in lockdown due to immoderate cases going up. In terms of the marketplace, when everything is closed, the demands for maty products and services including clothing started to shrink significantly in the first few months. Therefore, companies, corporations, and local businesses whether they were medium or large, it somehow affected them in various ways. Some enterprises had a hard time making meet ends struggling to survive and some are encountering bankruptcy. Ever since COVID-19 existed, not only has it affected people’s lives, it also affects the nation as a whole. It is quite worrisome that most of the fundamental sectors in Cambodia such as the garment, tourism, agriculture, and transport have now run into numerous difficulties. Regarding transportation, neither imports nor exports are being traded, some countries even closed their borders for their safety. Not to mention tourism where some airlines have declared bankruptcy because tourists are nowhere to be found. The garment [actories in Cambodia and across Southeast Asia were also severely alfected by the pandemic. ‘I’he majority of the population in impoverished countries are mostly blue-collar workers because they have limited access to education, which is the reason why Europe or any other parts of the world like having their products being made here with low wages provided and they can make more profits. However, with the demands from Europe and other parts of the world diminished, these workers are facing massive layoffs and the unemployment rate, especially in developing countries such as Cambodia increased dramatically.
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Flachsbart, B. R., S. Prakash, J. Yeom, Y. Wu, G. Z. Mozsgai, Z. C. Leseman, K. Wong, et al. "Theory, Fabrication, and Characterization of MEMS Devices: An Interdisciplinary Course for Mechanical Engineers." In ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-13741.
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The need to provide students with hands-on instruction in the fabrication of Microelectromechanical Systems (MEMS) led to the development of an upper-undergraduate, introductory-graduate, laboratory course offered each spring in the Department of Mechanical Science and Engineering (MechSE). The laboratory is taught in a class 100 cleanroom located in, and operated by, the MechSE department. Fabrication and testing of two MEMS device projects, a piezoresistive membrane pressure sensor and a microfluidic logic chip, facilitate the teaching of standard fabrication procedures, fabrication tool operation, and cleanroom protocols. The course appeals across disciplines as evident by half the students coming from other departments (chemical engineering, chemistry, material science, physics, electrical engineering, aeronautical engineering, etc.). The course also serves to attract prospective graduate students as many students continue to use the cleanroom in their graduate level research. This course broadly covers MEMS fabrication theory while maintaining a focus on practical understanding and laboratory application of that theory. The lecture is tied closely to the laboratory work by covering the tool and procedure theory that is used in the lab each week. An exciting aspect of the course is the hands-on learning experience the students get by independently operating the fabrication equipment themselves, including metal deposition tools, reactive ion etch (RIE) tools, lithography tools (spinners, mask aligners, etc.), and bath etchers and cleaners. Safety is an important aspect of the course where students are tested on safety protocol, Material Safety Data Sheet (MSDS) and National Fire Protection Agency (NFPA) familiarity, personal protection procedures, etc. The students also learn benchmark fabrication procedures including standard cleaning protocols (with ultrasonics), the Bosch RIE etching of silicon microstructures, and anisotropic etching of silicon. The piezoresistive membrane pressure sensor project facilitates an understanding of the residual stresses involved in thin-film deposition, stress-strain relationships, and signal analysis for transduction mechanisms. The microfluidic logic chip project, a chip of logic gates (NAND, NOR, etc.) and a half-adder, facilitates understanding fundamental principles of microfluidics, the Navier-Stokes equation, and flow in microchannels. This course, originally sponsored by Intel Corporation, prepares Mechanical Engineers in a multi-disciplinary environment to learn both the practical fundamentals and the theoretical basis of basic and advanced microfabrication that goes beyond the usual CMOS fabrication theory and methodology taught in Electrical Engineering for the microelectronics bound students. As evident from its popularity, the course also serves to excite and equip students for the important Mechanical Engineering field of MEMS.
Reports on the topic "NCR Corporation"
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Bacon and Olsen. PR-179-13202-R01 Field Evaluation of a Continental Controls Corp. NSCR NOx Sensor Control System. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), June 2014. http://dx.doi.org/10.55274/r0010203.
Full textAbstract:
Emissions compliance of stationary engines can be successful with the application of a non-selective catalytic reduction (NSCR) after treatment system. To accomplish this, the equivalence ratio (?) must be precisely controlled within a narrow range near stoichiometric conditions. The ability for Air Fuel Ratio (AFR) control systems to maintain the engine equivalence ratio in the required narrow operating range long term under field conditions has not been established. This project builds upon prior work at the Colorado State University (CSU) Engines and Energy Conversion Laboratory (EECL) to develop a NOx sensor minimization control algorithm utilizing an AFR controller manufactured by Continental Controls Corporation. Testing was performed on a Waukesha VGF-series L36GSI engine utilized for power generation.
2
Carpenter, Marie, and William Lazonick. The Pursuit of Shareholder Value: Cisco’s Transformation from Innovation to Financialization. Institute for New Economic Thinking Working Paper Series, February 2023. http://dx.doi.org/10.36687/inetwp202.
Full textAbstract:
Once the global leader in telecommunication systems and the Internet, over the past two decades the United States has fallen behind global competitors, and in particular China, in mobile communication infrastructure—specifically 5G and Internet of Things (IoT). This national failure, with the socioeconomic and geopolitical tensions that it creates, is not due to a lack of US government investment in the knowledge required for the mobility revolution. Nor is it because of a dearth of domestic demand for the equipment, devices, and applications that can make use of this infrastructure. Rather, the problem is the dereliction of key US-based business corporations to take the lead in making the investments in organizational learning required to generate cutting edge communication-infrastructure products. No company in the United States exemplifies this deficiency more than Cisco Systems, the business corporation founded in Silicon Valley in 1984 that had explosive growth in the 1990s to become the foremost global enterprise-networking equipment producer in the Internet revolution. This paper provides in-depth analysis of Cisco’s organizational failure, attributing it ultimately to the company’s turn from innovation in the last decades of 20th century to financialization in the early decades of the 21st century. Since 2001, Cisco’s top management has chosen to allocate corporate cash to open-market share repurchases— aka stock buybacks—for the purpose of giving manipulative boosts to the company stock price rather than make the investments in organizational learning required to become a world leader in communication-infrastructure equipment for the era of 5G and IoT. From October 2001 through October 2022, Cisco spent $152.3 billion—95 percent of its net income over the period—on stock buybacks for the purpose of propping up its stock price. These funds wasted in pursuit of “maximizing shareholder value” were on top of the $55.5 billion that Cisco paid out to shareholders in dividends, representing an additional 35 percent of net income. In this paper, we trace how Cisco grew from a Silicon Valley startup in 1984 to become, through its innovative products, the world leader in enterprise-networking equipment over the next decade and a half. As the company entered the 21st century, building on its dominance of enterprise-networking, Cisco was positioned to upgrade its technological capabilities to become a major infrastructureequipment vendor to service providers. We analyze how and why, when the Internet boom turned to bust in 2001, the organizational structure that enabled Cisco to dominate enterprise networking posed constraints related to manufacturing and marketing on the company’s growth in the more sophisticated infrastructure-equipment segment. We then document how from 2002 Cisco turned from innovation to financialization, as it used its ample profits to do stock buybacks to prop up its stock price. Finally, we ponder the larger policy implications of Cisco’s turn from innovation to financialization for the competitive position of the US information-and-communication technology (ICT) industry in the global economy.
3
Vargas-Herrera, Hernando, Pamela Andrea Cardozo-Ortiz, Clara Lía Machado-Franco, Carlos Alberto Cadena-Silva, Freddy Hernán Cepeda-López, Aura María Ciceri-Lozano, Carlos Eduardo León-Rincón, et al. Reporte de Sistemas de Pago - Junio de 2021. Banco de la República de Colombia, July 2021. http://dx.doi.org/10.32468/rept-sist-pag.2021.
Full textAbstract:
El Banco de la República, con el Reporte de Sistemas de Pago, entrega un panorama completo de la infraestructura financiera local, siendo este un producto importante de la labor de seguimiento a dicha infraestructura. Las cifras contenidas en este reporte corresponden al año 2020, período de pandemia durante el cual las medidas de confinamiento para aliviar la tensión sobre el sistema de salud generaron para Colombia, al igual que en la mayoría de los países, una fuerte reducción de la actividad económica y el consumo. Desde el comienzo de la pandemia, la Junta Directiva del Banco de la República adoptó las decisiones necesarias para otorgar al mercado amplia liquidez en pesos y dólares, garantizar la estabilidad de los mercados, proteger el sistema de pagos y preservar la oferta de crédito. El pronunciado crecimiento de los agregados monetarios reflejó la mayor preferencia por liquidez, la cual fue atendida oportunamente por el Banco de la República. Las decisiones adoptadas se realizaron mediante diferentes operaciones, las cuales fueron compensadas y liquidadas en la infraestructura financiera. Después de la introducción, la segunda sección del presente reporte de pagos analiza la evolución y el desempeño de las diferentes infraestructuras financieras. Se destaca que el sistema de pagos de alto valor CUD registró en 2020 un mayor dinamismo que el año anterior, principalmente por el aumento de los depósitos remunerados que en promedio diario realizó la Dirección General de Crédito Público y del Tesoro Nacional (DGCPTN) con el Banco de República, así como una mayor actividad del mercado de simultáneas de deuda pública. Consecuentemente con el crecimiento de la actividad en el CUD, el Depósito Central de Valores (DCV) registró una mayor actividad por el aumento del mercado monetario de deuda pública y por las colocaciones por parte del Gobierno Nacional en el mercado primario. El valor de las operaciones compensadas y liquidadas por intermedio de la Cámara de Riesgo Central de Contraparte (CRCC) continúa creciendo, jalonado principalmente por los contratos non delivery forward (NDF) peso/dólar. Con respecto a la CRCC, es oportuno mencionar que a partir de finales del año pasado esta cámara se encarga de administrar los riesgos y de compensar y liquidar las operaciones del mercado de contado peso/dólar, debido a la fusión con la Cámara de Compensación de Divisas de Colombia (CCDC). Así mismo, a partir del último trimestre del año 2020 la CRCC se encarga de compensar y liquidar el mercado de renta variable, labor que venía desempeñando la Bolsa de Valores de Colombia (BVC). En la sección tres se entrega una visión integral de los pagos en el mercado de bienes y servicios, es decir, de las transacciones efectuadas en el circuito de personas naturales y empresas no financieras. Durante la pandemia las transferencias electrónicas inter e intrabancarias, que en su mayoría son originadas por empresas, registraron un incremento tanto en número como en valor de operaciones frente a 2019. Por su parte, los pagos con tarjetas débito y crédito originados principalmente por personas naturales mostraron un comportamiento decreciente con respecto a 2019. Los pagos realizados con cheques siguen disminuyendo, presentando una tendencia a la baja muy pronunciada en el último año. Como complemento a la información sobre transferencias electrónicas, el reporte incluye en esta sección un sombreado sobre la caracterización de la población con cuenta de ahorro y corriente, empleando los datos de la encuesta del Banco de la República sobre percepción de uso de los instrumentos de pago en 2019. Se incluye también un recuadro sobre la evolución transaccional de una billetera móvil provista por una sociedad especializada en depósitos y pagos electrónicos (Sedpe), mostrando que desde su creación a finales del año 2017 ha incremento en el número de usuarios y el valor de las transacciones, con especial velocidad durante la pandemia. Adicionalmente, se presenta un diagnóstico sobre los efectos de la pandemia en los patrones de pago de la población, fundamentado en datos sobre el uso del efectivo en circulación, sobre los pagos con instrumentos electrónicos, y sobre el consumo y la confianza del consumidor. Se concluye que el desplome en el índice de confianza del consumidor y la caída en el consumo privado dieron lugar a cambios en los patrones de pago de las personas. Las compras con tarjetas de crédito y débito disminuyeron, mientras que los pagos por bienes y servicios mediante transferencia electrónica aumentaron. Estos resultados, junto con el considerable aumento del efectivo en circulación, podrían proveer indicios a favor de un posible atesoramiento del papel moneda con motivo precaución por parte de las personas y de un mayor uso del efectivo como instrumento de pago. Se incluye, además, un recuadro que presenta los principales cambios que se introdujeron en la regulación del sistema de pagos de bajo valor en el país mediante la expedición del Decreto 1692 de diciembre de 2020. La cuarta sección se refiere a las importantes innovaciones y cambios tecnológicos que se han observado en el sistema de pagos al por menor. Se destacan cuatro temas en esta línea. El primero se constituye en un punto clave para la construcción de la infraestructura financiera de pagos inmediatos. Consiste en el diseño e implementación de los llamados esquemas superpuestos, los cuales son un desarrollo tecnológico que permite una comunicación abierta entre los diferentes agentes de la cadena de pagos, logrando una alta interoperabilidad entre diferentes proveedores de servicios de pago. El segundo tema explora los avances en el debate internacional sobre la emisión de moneda digital por parte de los bancos centrales (CBDC por su sigla en inglés), con el fin de entender su posible impacto en el sistema de pagos de bajo valor y en el uso del efectivo. El tercer tema está relacionado con nuevas formas de iniciación de pagos, tales como los códigos QR, la biometría o la tecnología de comunicación de campos cercanos (NCF por su sigla en inglés). Estos cambios, aparentemente pequeños, pueden tener efectos importantes en la experiencia del usuario con el sistema de pagos de bajo valor. El cuarto tema, finalmente, es el crecimiento de los pagos vinculados con la telefonía móvil y el internet. El reporte finaliza en la sección cinco con una reseña de dos trabajos de investigación aplicada realizados en el Banco de la República en el año 2020. El primero analiza el nivel patrimonial de la CRCC, reconociendo el rol relevante que esta infraestructura ha adquirido en la compensación y liquidación de varios mercados financieros en el país. Se exploran los requerimientos de capital para las entidades de contrapartida central establecidos en algunas jurisdicciones, se identifican los riesgos que se busca cubrir desde la perspectiva del servicio que este tipo de entidades ofrece al mercado y aquellos asociados a su actividad corporativa. Se analizan los niveles patrimoniales de la CRCC a partir de lo observado en la regulación de la Unión Europea y se concluye que la CRCC cuenta con un esquema de anillos de seguridad muy similar al observado en la experiencia internacional y que su nivel patrimonial es superior al exigido por la regulación colombiana, siendo suficiente para cubrir otros riesgos. El segundo trabajo de investigación identifica y cuantifica las fuentes que utilizan las entidades participantes en el CUD para cumplir con sus obligaciones diarias contraídas en el mercado financiero local, y con su uso como herramienta de monitoreo de la liquidez intradía en condiciones normales. Leonardo Villar Gómez Gerente General