Journal articles: 'Natural products and bioactive compounds'

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Carroll, Anthony R., Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, and Michèle R. Prinsep. "Marine natural products." Natural Product Reports 37, no. 2 (2020): 175–223. http://dx.doi.org/10.1039/c9np00069k.

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Ouma, Stephen, Richard Kagia, and Faith Kamakia. "Determination of pharmacological activity of bioactives in Allium sativum using computational analysis." F1000Research 12 (February 9, 2023): 151. http://dx.doi.org/10.12688/f1000research.130105.1.

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Introduction: Use of natural products for management of diseases has increased widely due to the belief that natural products are less toxic than conventional medicines. Natural products have been utilised for management of chronic diseases such as diabetes and cancers. Respiratory infections have also been managed using natural products. Allium sativum is one of the natural products that has been utilised in the management of SARS-CoV infections, diabetes and cancer. Methods: This study was aimed at screening bioactive agents in Allium sativum using computational analysis. The targets of the bioactive agents were predicted using SwissTargetPrediction tools. Molecular docking followed, where the docking energies of the bioactive agents to the targets were generated. The bioactive agents were analysed for pharmacokinetics properties using SwissADME as well as toxicity profiles using the ProTox II webserver. The docking scores, toxicities and pharmacokinetics profiles of the bioactive agents in Allium sativum were compared with those of reference compounds. Results: All the bioactives showed lower docking scores than the reference compounds. The bioactives, however, showed some activity on specific receptors such as carbonic anhydrases, cyclooxygenase and ghrelin. All the bioactives showed high gastrointestinal tract absorption and none violated Lipinski’s rule of five. Diallyl trisulphide was predicted to be most lethal, with an LD50 of 100mg/kg, while was the safest, with 8000mg/kg. Conclusions: In conclusion, bioactives showed lower docking scores than the reference compounds, therefore overall pharmacological activity could be attributed to synergy between the bioactives for a particular receptor.

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Lin, Hsiao-Ching, Ranuka T. Hewage, Yuan-Chun Lu, and Yit-Heng Chooi. "Biosynthesis of bioactive natural products from Basidiomycota." Organic & Biomolecular Chemistry 17, no. 5 (2019): 1027–36. http://dx.doi.org/10.1039/c8ob02774a.

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Chua, Lee Suan. "Bioactive compounds from natural products with antidiabetic potentials." Longhua Chinese Medicine 5 (March 2022): 1. http://dx.doi.org/10.21037/lcm-21-64.

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Gallo, Monica. "Extraction and Isolation of Natural Products." Separations 9, no. 10 (October 5, 2022): 287. http://dx.doi.org/10.3390/separations9100287.

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Liu, Ji-Hua, and Bo-Yang Yu. "Biotransformation of Bioactive Natural Products for Pharmaceutical Lead Compounds." Current Organic Chemistry 14, no. 14 (August 1, 2010): 1400–1406. http://dx.doi.org/10.2174/138527210791616786.

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Vamanu, Emanuel. "Bioactive Compounds from Natural Products: Separation, Characterization, and Applications." Applied Sciences 12, no. 8 (April 13, 2022): 3922. http://dx.doi.org/10.3390/app12083922.

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Molinski, Tadeusz F. "Developments in Marine Natural Products. Receptor-Specific Bioactive Compounds." Journal of Natural Products 56, no. 1 (January 1993): 1–8. http://dx.doi.org/10.1021/np50091a001.

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Kurtboke, Ipek. "Bacteriophages as tools in drug discovery programs." Microbiology Australia 31, no. 2 (2010): 67. http://dx.doi.org/10.1071/ma10067.

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Screening of microbial natural products continues to represent an important route to the discovery of novel bioactive compounds for the development of new therapeutic or other important industrial agents. However, a continuous supply of diverse compounds is needed to meet the needs of industry. Such a supply can only be derived through systematic screening of bioactive compound-producing microorganisms from natural sources.

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Zamani, N. P., L. Rahman, R. L. Rosada, and W. Tirtama. "Overview of bioactivity studies on marine natural products." IOP Conference Series: Earth and Environmental Science 944, no. 1 (December 1, 2021): 012029. http://dx.doi.org/10.1088/1755-1315/944/1/012029.

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Abstract Marine natural products are sourced from marine biodiversity as natural raw materials for various commercial products. This study aims to review natural products of marine organisms and gap analysis for future research or challenges. A total of 109 references from 24 countries were collected. The analysis was carried out quantitatively and qualitatively. The bioactive compounds produced wereantioxidants, antibacterial, anticancer, antimicrobial, anti-fouling, antifungal, and anti-tumoral substances. Some marine organisms that can store chemical compounds through secondary metabolite processes are mangroves, seagrasses, macroalgae, microalgae, soft corals, molluscs, echinoderms, gastropods, cnidarians, sponges, fungi, and bacteria. Most of the papers only discuss the identification stage of the active compound, and some focus on product development. There are very few studies on prospects of commercialization and mass production. The problem to achieve mass production is due to the lack of interdisciplinary research collaboration. Future research challenges need to develop a transdisciplinary approach to study bioprospection research from upstream to downstream, starting from the potential identification of bioactive ingredients, product development, the availability of raw materials for mass production as well as commercialization and marketing.

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Otvos, Reka A., Kristina B. M. Still, Govert W. Somsen, August B. Smit, and Jeroen Kool. "Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays." SLAS DISCOVERY: Advancing the Science of Drug Discovery 24, no. 3 (January 25, 2019): 362–85. http://dx.doi.org/10.1177/2472555218822098.

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Natural extracts are complex mixtures that may be rich in useful bioactive compounds and therefore are attractive sources for new leads in drug discovery. This review describes drug discovery from natural products and in explaining this process puts the focus on ion-channel drug discovery. In particular, the identification of bioactives from natural products targeting nicotinic acetylcholine receptors (nAChRs) and serotonin type 3 receptors (5-HT3Rs) is discussed. The review is divided into three parts: “Targets,” “Sources,” and “Approaches.” The “Targets” part will discuss the importance of ion-channel drug targets in general, and the α7-nAChR and 5-HT3Rs in particular. The “Sources” part will discuss the relevance for drug discovery of finding bioactive compounds from various natural sources such as venoms and plant extracts. The “Approaches” part will give an overview of classical and new analytical approaches that are used for the identification of new bioactive compounds with the focus on targeting ion channels. In addition, a selected overview is given of traditional venom-based drug discovery approaches and of diverse hyphenated analytical systems used for screening complex bioactive mixtures including venoms.

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Shi, Ting, Yi-Fei Wang, Han Wang, and Bo Wang. "Genus Nocardiopsis: A Prolific Producer of Natural Products." Marine Drugs 20, no. 6 (May 31, 2022): 374. http://dx.doi.org/10.3390/md20060374.

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Actinomycetes are currently one of the major sources of bioactive secondary metabolites used for medicine development. Accumulating evidence has shown that Nocardiopsis, a key class of actinomycetes, has the ability to produce novel bioactive natural products. This review covers the sources, distribution, bioactivities, biosynthesis, and structural characteristics of compounds isolated from Nocardiopsis in the period between March 2018 and 2021. Our results reveal that 67% of Nocardiopsis-derived natural products are reported for the first time, and 73% of them are isolated from marine Nocardiopsis. The chemical structures of the Nocardiopsis-derived compounds have diverse skeletons, concentrating on the categories of polyketides, peptides, terphenyls, and alkaloids. Almost 50% of the natural products isolated from Nocardiopsis have been discovered to display various bioactivities. These results fully demonstrate the great potential of the genus Nocardiopsis to produce novel bioactive secondary metabolites that may serve as a structural foundation for the development of novel drugs.

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Verma, Vijay C., Ravindra N. Kharwar, and Gary A. Strobel. "Chemical and Functional Diversity of Natural Products from Plant Associated Endophytic Fungi." Natural Product Communications 4, no. 11 (November 2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401114.

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This review describes examples of naturally occurring bioactive compounds obtained from fungal endophytes from various host plants. The main topics addressed are sources, identification, biological activity, biosynthesis, and ecological and chemosystematic significance of those bioactive compounds whose sources were well defined.

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Badr, Ahmed Noah, Karolina Gromadzka, Mohamed Gamal Shehata, Kinga Stuper-Szablewska, Kinga Drzewiecka, and Adel Gabr Abdel-Razek. "Prospective antimycotoxigenic action of wild Opuntia ficus-indica by-products." Czech Journal of Food Sciences 38, No. 5 (October 30, 2020): 308–14. http://dx.doi.org/10.17221/11/2020-cjfs.

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Numerous natural compounds perform pharmaceutical, antimycotic and antitoxic purposes in the body system. The aim was to evaluate new phytoconstituents that provide antimycotoxigenic properties against mycotoxins. Bioactive materials chosen were fruit peels and cladodes of wild Opuntia ficus-indica containing a measurable quantity of bioactive phytochemicals. The highest concentration of bioactive metabolites was recorded for protocatechuic and t-cinnamic acids. A reduction effect of bioactives was estimated against aflatoxins, ochratoxin A and zearalenone in a simulated body system. Antifungal activity was determined in liquid media to evaluate antimycotic properties. Lyophilised extracts caused an aflatoxin reduction in media by 14.65% to 23.77% for fruit peels and cladodes, respectively. It caused a decrease of 59% zearalenone and 51% of ochratoxin A in a in a simulated body fluid. The cladode extract manifested better antimycotic and antimycotoxigenic characteristics due to its bioactive contents. These results support a modern antimycotoxin trend of food preservation that has a considerable impact on food safety.

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Sang, Dat, Vinh, Cuong, Oanh, Ha, Kim, Anh, and Yang. "Coral and Coral-Associated Microorganisms: A Prolific Source of Potential Bioactive Natural Products." Marine Drugs 17, no. 8 (August 11, 2019): 468. http://dx.doi.org/10.3390/md17080468.

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Marine invertebrates and their associated microorganisms are rich sources of bioactive compounds. Among them, coral and its associated microorganisms are promising providers of marine bioactive compounds. The present review provides an overview of bioactive compounds that are produced by corals and coral-associated microorganisms, covering the literature from 2010 to March 2019. Accordingly, 245 natural products that possess a wide range of potent bioactivities, such as anti-inflammatory, cytotoxic, antimicrobial, antivirus, and antifouling activities, among others, are described in this review.

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Yang, Chengfang, Rui Qian, Yao Xu, Junxi Yi, Yiwen Gu, Xiaoyu Liu, Haobing Yu, Binghua Jiao, Xiaoling Lu, and Wei Zhang. "Marine Actinomycetes-derived Natural Products." Current Topics in Medicinal Chemistry 19, no. 31 (January 3, 2020): 2868–918. http://dx.doi.org/10.2174/1568026619666191114102359.

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: Actinomycetes is an abundant resource for discovering a large number of lead compounds, which play an important role in microbial drug discovery. Compared to terrestrial microorganisms, marine actinomycetes have unique metabolic pathways because of their special living environment, which has the potential to produce a variety of bioactive substances. In this paper, secondary metabolites isolated from marine actinomycetes are reviewed (2013-2018), most of which exhibited cytotoxic, antibacterial, and antiviral biological activities.

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Bouzroud, Sarah, Ezzouhra El Maaiden, Mansour Sobeh, Nawal Merghoub, Hassan Boukcim, Lamfeddal Kouisni, and Youssef El Kharrassi. "Biotechnological Approaches to Producing Natural Antioxidants: Anti-Ageing and Skin Longevity Prospects." International Journal of Molecular Sciences 24, no. 2 (January 11, 2023): 1397. http://dx.doi.org/10.3390/ijms24021397.

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Plants are the main source of bioactive compounds that can be used for the formulation of cosmetic products. Plant extracts have numerous proven health benefits, among which are anti-ageing and skin-care properties. However, with the increased demand for plant-derived cosmetic products, there is a crucial prerequisite for establishing alternative approaches to conventional methods to ensure sufficient biomass for sustainable production. Plant tissue culture techniques, such as in vitro root cultures, micropropagation, or callogenesis, offer the possibility to produce considerable amounts of bioactive compounds independent of external factors that may influence their production. This production can also be significantly increased with the implementation of other biotechnological approaches such as elicitation, metabolic engineering, precursor and/or nutrient feeding, immobilization, and permeabilization. This work aimed to evaluate the potential of biotechnological tools for producing bioactive compounds, with a focus on bioactive compounds with anti-ageing properties, which can be used for the development of green-label cosmeceutical products. In addition, some examples demonstrating the use of plant tissue culture techniques to produce high-value bioactive ingredients for cosmeceutical applications are also addressed, showing the importance of these tools and approaches for the sustainable production of plant-derived cosmetic products.

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Wang, Yifei, Xiaowen Yang, Yanjing Li, Bo Wang, and Ting Shi. "The Genus Chrysosporium: A Potential Producer of Natural Products." Fermentation 9, no. 1 (January 16, 2023): 76. http://dx.doi.org/10.3390/fermentation9010076.

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Chrysosporium, a genus of ascomycete fungi in the family Onygenaceae, has the ability to produce abundant new bioactive natural products, providing a structural foundation in drug development. This review includes the sources, distribution, biological activities and structural characteristics of the compounds isolated from Chrysosporium from 1984 to 2021. The results show that 66% of the compounds isolated from Chrysosporium are new natural products. More than half of the Chrysosporium-isolated compounds are from marine-derived Chrysosporium. The chemical structures of Chrysosporium-derived compounds have different skeletons, which are concentrated in alkaloids, polyketides, and lactones. Eighty percent of the natural products isolated from Chrysosporium have been found to have various biological activities, including cytotoxic, antibacterial, antifungal and enzyme-inhibitory activities. These results demonstrate the potential of Chrysosporium for producing new bioactive secondary metabolites, which can be used as the structural basis for developing new drugs.

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Kurita, Kenji L., Emerson Glassey, and Roger G. Linington. "Integration of high-content screening and untargeted metabolomics for comprehensive functional annotation of natural product libraries." Proceedings of the National Academy of Sciences 112, no. 39 (September 14, 2015): 11999–2004. http://dx.doi.org/10.1073/pnas.1507743112.

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Traditional natural products discovery using a combination of live/dead screening followed by iterative bioassay-guided fractionation affords no information about compound structure or mode of action until late in the discovery process. This leads to high rates of rediscovery and low probabilities of finding compounds with unique biological and/or chemical properties. By integrating image-based phenotypic screening in HeLa cells with high-resolution untargeted metabolomics analysis, we have developed a new platform, termed Compound Activity Mapping, that is capable of directly predicting the identities and modes of action of bioactive constituents for any complex natural product extract library. This new tool can be used to rapidly identify novel bioactive constituents and provide predictions of compound modes of action directly from primary screening data. This approach inverts the natural products discovery process from the existing ‟grind and find” model to a targeted, hypothesis-driven discovery model where the chemical features and biological function of bioactive metabolites are known early in the screening workflow, and lead compounds can be rationally selected based on biological and/or chemical novelty. We demonstrate the utility of the Compound Activity Mapping platform by combining 10,977 mass spectral features and 58,032 biological measurements from a library of 234 natural products extracts and integrating these two datasets to identify 13 clusters of fractions containing 11 known compound families and four new compounds. Using Compound Activity Mapping we discovered the quinocinnolinomycins, a new family of natural products with a unique carbon skeleton that cause endoplasmic reticulum stress.

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Dian Rachma Wijayanti and Almatin Puspa Dewi. "Extraction and Identification Potent Antibacterial Bioactive Compound of Streptomyces sp. MB 106 from Euphorbia sp. Rhizosphere." BIOEDUSCIENCE 6, no. 1 (April 30, 2022): 84–88. http://dx.doi.org/10.22236/j.bes/617898.

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Background: Actinomycetes are groups of bacteria that play an important role in pharmacy and medicine in their ability to produce secondary metabolites in the form of bioactive compounds with various chemical structures and biological activities. The genus Streptomyces produces more than 70% of all described actinomycetes natural products. In particular, antibiotics represent the largest group. Through mutations, bacteria may survive chemotherapy. Thus its infection is hard to eradicate. Therefore the search for new potent bioactive compounds is important Methods: Isolate preparation, Production, and extraction bioactive compound, Crude extract antibacterial test, Identification of bioactive compound Results: There are antibacterial activities per 100 µl crude extract. Inhibition zone range from 11.5 to 13 mm. Various bioactive compounds detected in n-Butanol extract, There are nine bioactive compounds detected from Streptomyces sp. MB 106 crude extract. The highest was Naphthalene (43.89 %). The lowest was 3-Imino-3h,5h- [1,2,4] Thiadiazolo [3,4-1] Isoindole (1.70 %). Six compounds were reported to have antimicrobial activities butane, 1,1-dibutoxy, naphthalene, nonadecane, docosane, heneicosane, and eicosane Conclusions: Crude extract showed an average of 12 mm inhibition zone against Escherichia coli ATCC 8739. There are nine bioactive compounds from Streptomyces sp. MB 106. Six of them are promising drugs candidate. Further studies on these compounds are essential for future drugs candidate.

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GHOSH, Subrata, and Raymond J. PLAYFORD. "Bioactive natural compounds for the treatment of gastrointestinal disorders." Clinical Science 104, no. 6 (June 1, 2003): 547–56. http://dx.doi.org/10.1042/cs20030067.

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Many healthy subjects and patients are taking natural bioactive products for the prevention and treatment of multiple conditions, including gastrointestinal disorders. Based on current evidence, the scientific validity of the use of many of these commercial compounds by the general public is severely limited, with quality control and regulatory issues continuing to be a concern. Nevertheless, there is sufficient preliminary data to warrant further research of these products in order to identify novel compounds for potential clinical use in addition to performing formal randomized controlled clinical trials of the commercial preparations.

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Asma, Syeda Tasmia, Ulas Acaroz, Kálmán Imre, Adriana Morar, Syed Rizwan Ali Shah, Syed Zajif Hussain, Damla Arslan-Acaroz, et al. "Natural Products/Bioactive Compounds as a Source of Anticancer Drugs." Cancers 14, no. 24 (December 15, 2022): 6203. http://dx.doi.org/10.3390/cancers14246203.

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Cancer is one of the major deadly diseases globally. The alarming rise in the mortality rate due to this disease attracks attention towards discovering potent anticancer agents to overcome its mortality rate. The discovery of novel and effective anticancer agents from natural sources has been the main point of interest in pharmaceutical research because of attractive natural therapeutic agents with an immense chemical diversity in species of animals, plants, and microorganisms. More than 60% of contemporary anticancer drugs, in one form or another, have originated from natural sources. Plants and microbial species are chosen based on their composition, ecology, phytochemical, and ethnopharmacological properties. Plants and their derivatives have played a significant role in producing effective anticancer agents. Some plant derivatives include vincristine, vinblastine, irinotecan, topotecan, etoposide, podophyllotoxin, and paclitaxel. Based on their particular activity, a number of other plant-derived bioactive compounds are in the clinical development phase against cancer, such as gimatecan, elomotecan, etc. Additionally, the conjugation of natural compounds with anti-cancerous drugs, or some polymeric carriers particularly targeted to epitopes on the site of interest to tumors, can generate effective targeted treatment therapies. Cognizance from such pharmaceutical research studies would yield alternative drug development strategies through natural sources which could be economical, more reliable, and safe to use.

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Saxena, Sanjai, Manmohan Chhibber, and Inder Pal Singh. "Fungal Bioactive Compounds in Pharmaceutical Research and Development." Current Bioactive Compounds 15, no. 2 (March 12, 2019): 211–31. http://dx.doi.org/10.2174/1573407214666180622104720.

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Background:Exploration of antibiotics from microorganisms became widespread in the academia and the industry with the serendipitous discovery of Penicillin from Penicillium notatum by Sir Alexander Fleming. This embarked the golden era of antibiotics which lasted for over 60 years. However, the traditional phenotypic screening was replaced with more rational and smarter methods of exploration of bioactive compounds from fungi and microorganisms. Fungi have been responsible for providing a variety of bioactive compounds with diverse activities which have been developed into blockbuster drugs such as Cyclosporine, Caspofungin, Lovastatin and Fingolimod etc. It has been reported that ca. 40% of the 1453 New Chemical Entities (NCE’s) approved by USFDA are natural products, natural product inspired or mimics many of which have their origins from fungi. Hence fungal compounds are playing a very important role in drug discovery and development in the pharmaceutical industry.Methods:We undertook structured searches of bibliographic databases of peer-reviewed research literature which pertained to natural products, medicinal chemistry of natural products and drug discovery from fungi. With the strategic improvement in screening and identification methods, fungi are still a potential resource for novel chemistries. Thus the searches also comprised of bioactive agents from fungi isolated or derived from special ecological groups and lineages. To find different molecules derived or isolated from fungi under clinical studies, clinical trial data from the NIH as well as from pharmaceutical companies were also explored. This comprised of data wherein the pharmaceutical industries have acquired or licensed a fungal bioactive compound for clinical study or a trial.Results:Natural product chemistry and medicinal chemistry continue to play an important role in converting a bioactive compound into therapeutic moieties or pharmacophores for new drug development.Conclusion:Thus one can say fungal bioactive compounds are alive and well for development into new drugs as novel ecological groups of fungi as well as novel chemistries are being uncovered. This review further emphasizes the collaboration of fungal biologists with chemists, pharmacologists and biochemists towards the development of newer drugs for taking them into the drug development pipeline.

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Avila, Conxita, and Carlos Angulo-Preckler. "Bioactive Compounds from Marine Heterobranchs." Marine Drugs 18, no. 12 (December 21, 2020): 657. http://dx.doi.org/10.3390/md18120657.

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The natural products of heterobranch molluscs display a huge variability both in structure and in their bioactivity. Despite the considerable lack of information, it can be observed from the recent literature that this group of animals possesses an astonishing arsenal of molecules from different origins that provide the molluscs with potent chemicals that are ecologically and pharmacologically relevant. In this review, we analyze the bioactivity of more than 450 compounds from ca. 400 species of heterobranch molluscs that are useful for the snails to protect themselves in different ways and/or that may be useful to us because of their pharmacological activities. Their ecological activities include predator avoidance, toxicity, antimicrobials, antifouling, trail-following and alarm pheromones, sunscreens and UV protection, tissue regeneration, and others. The most studied ecological activity is predation avoidance, followed by toxicity. Their pharmacological activities consist of cytotoxicity and antitumoral activity; antibiotic, antiparasitic, antiviral, and anti-inflammatory activity; and activity against neurodegenerative diseases and others. The most studied pharmacological activities are cytotoxicity and anticancer activities, followed by antibiotic activity. Overall, it can be observed that heterobranch molluscs are extremely interesting in regard to the study of marine natural products in terms of both chemical ecology and biotechnology studies, providing many leads for further detailed research in these fields in the near future.

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Fatope, M. O., Salma M. Z. Al-Kindi, and Abdulrahman O. Abdulnour. "Research Trends : Natural Products as Pest, Microbial Disease an Tumour Control Agents." Sultan Qaboos University Journal for Science [SQUJS] 5 (December 1, 2000): 55. http://dx.doi.org/10.24200/squjs.vol5iss0pp55-71.

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The zeal to conquer human, agronomic, and veterinary diseases or pests has always sustained research interests directed at finding new medications from under explored biodiversity. The adoption of bioassay methods, which correlate with prevention, inhibition and reversal of diseases or elimination of pests, in screening natural products for bioactive compounds is critical to the discovery of new medications. This article focuses on areas of natural products chemistry that connect academia with industry. It discusses the technical skills needed to find bioactive compounds from microbes, marine invertebrates, plants and insects, highlighting the mode of action of selected bioactive compounds and bioassay models for detecting them. It also reviews methods and prospects of genetic manipulation of organisms to produce unnatural natural products of therapeutic importance.

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Francioso, Antonio. "Isolation, Determination and Analysis of Bioactive Natural Sulfur Compounds." Separations 10, no. 2 (January 17, 2023): 67. http://dx.doi.org/10.3390/separations10020067.

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Senthilkumar, Kalimuthu, and Se-Kwon Kim. "Marine Invertebrate Natural Products for Anti-Inflammatory and Chronic Diseases." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/572859.

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The marine environment represents a relatively available source of functional ingredients that can be applied to various aspects of food processing, storage, and fortification. Moreover, numerous marine invertebrates based compounds have biological activities and also interfere with the pathogenesis of diseases. Isolated compounds from marine invertebrates have been shown to pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), osteoporosis, and so forth. Extensive research within the last decade has revealed that most chronic illnesses such as cancer, neurological diseases, diabetes, and autoimmune diseases exhibit dysregulation of multiple cell signaling pathways that have been linked to inflammation. On the basis of their bioactive properties, this review focuses on the potential use of marine invertebrate derived compounds on anti-inflammatory and some chronic diseases such as cardiovascular disease, osteoporosis, diabetes, HIV, and cancer.

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Ferreira, Ana Sofia, Catarina Macedo, Ana Margarida Silva, Cristina Delerue-Matos, Paulo Costa, and Francisca Rodrigues. "Natural Products for the Prevention and Treatment of Oral Mucositis—A Review." International Journal of Molecular Sciences 23, no. 8 (April 15, 2022): 4385. http://dx.doi.org/10.3390/ijms23084385.

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Cancer, a major world public health problem, is associated with chemotherapy treatments whose administration leads to secondary concerns, such as oral mucositis (OM). The OM disorder is characterized by the presence of ulcers in the oral mucosa that cause pain, bleeding, and difficulty in ingesting fluids and solids, or speaking. Bioactive compounds from natural sources have arisen as an effective approach for OM. This review aims to summarize the new potential application of different natural products in the prevention and treatment of OM in comparison to conventional ones, also providing a deep insight into the most recent clinical studies. Natural products, such as Aloe vera, Glycyrrhiza glabra, Camellia sinensis, Calendula officinalis, or honeybee crops, constitute examples of sources of bioactive compounds with pharmacological interest due to their well-reported activities (e.g., antimicrobial, antiviral, anti-inflammatory, analgesic, or wound healing). These activities are associated with the bioactive compounds present in their matrix (such as flavonoids), which are associated with in vivo biological activities and minimal or absent toxicity. Finally, encapsulation has arisen as a future opportunity to preserve the chemical stability and the drug bioa vailability of bioactive compounds and, most importantly, to improve the buccal retention period and the therapeutic effects.

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Lorenzen, K., and T. Anke. "Basidiomycetes as a Source for New Bioactive Natural Products." Current Organic Chemistry 2, no. 4 (July 1998): 329–64. http://dx.doi.org/10.2174/1385272802666220128213627.

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Among the sources of bioactive metabolites, less intensively investigated organisms like the higher fungi seem to hold an excellent promise for new structures with interesting biological activities. In the last decades interesting compounds of different biogenetic origin with antibacterial, antifungal, phytotoxic, nematocidal, cytostatic, antiviral, and other pharmacological activities were isolated from basidiomycetes. In the following review we will concentrate on metabolites isolated from submerged cultures.

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Elgoud Said, Asmaa Abo, Basma Khalaf Mahmoud, Eman Zekry Attia, Usama Ramadan Abdelmohsen, and Mostafa Ahmed Fouad. "Bioactive natural products from marine sponges belonging to family Hymedesmiidae." RSC Advances 11, no. 27 (2021): 16179–91. http://dx.doi.org/10.1039/d1ra00228g.

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Park, Jihye, Bo Ram Beck, Hoo Hyun Kim, Sangbum Lee, and Keunsoo Kang. "A Brief Review of Machine Learning-Based Bioactive Compound Research." Applied Sciences 12, no. 6 (March 11, 2022): 2906. http://dx.doi.org/10.3390/app12062906.

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Bioactive compounds are often used as initial substances for many therapeutic agents. In recent years, both theoretical and practical innovations in hardware-assisted and fast-evolving machine learning (ML) have made it possible to identify desired bioactive compounds in chemical spaces, such as those in natural products (NPs). This review introduces how machine learning approaches can be used for the identification and evaluation of bioactive compounds. It also provides an overview of recent research trends in machine learning-based prediction and the evaluation of bioactive compounds by listing real-world examples along with various input data. In addition, several ML-based approaches to identify specific bioactive compounds for cardiovascular and metabolic diseases are described. Overall, these approaches are important for the discovery of novel bioactive compounds and provide new insights into the machine learning basis for various traditional applications of bioactive compound-related research.

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Shaaban, Khaled A. "Marine Microbial Diversity as Source of Bioactive Compounds." Marine Drugs 20, no. 5 (April 29, 2022): 304. http://dx.doi.org/10.3390/md20050304.

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Chávez-Hernández, Ana L., Norberto Sánchez-Cruz, and José L. Medina-Franco. "Fragment Library of Natural Products and Compound Databases for Drug Discovery." Biomolecules 10, no. 11 (November 6, 2020): 1518. http://dx.doi.org/10.3390/biom10111518.

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Natural products and semi-synthetic compounds continue to be a significant source of drug candidates for a broad range of diseases, including coronavirus disease 2019 (COVID-19), which is causing the current pandemic. Besides being attractive sources of bioactive compounds for further development or optimization, natural products are excellent substrates of unique substructures for fragment-based drug discovery. To this end, fragment libraries should be incorporated into automated drug design pipelines. However, public fragment libraries based on extensive collections of natural products are still limited. Herein, we report the generation and analysis of a fragment library of natural products derived from a database with more than 400,000 compounds. We also report fragment libraries of a large food chemical database and other compound datasets of interest in drug discovery, including compound libraries relevant for COVID-19 drug discovery. The fragment libraries were characterized in terms of content and diversity.

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Martí-Quijal, Francisco J., Sucheta Khubber, Fabienne Remize, Igor Tomasevic, Elena Roselló-Soto, and Francisco J. Barba. "Obtaining Antioxidants and Natural Preservatives from Food By-Products through Fermentation: A Review." Fermentation 7, no. 3 (July 7, 2021): 106. http://dx.doi.org/10.3390/fermentation7030106.

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Industrial food waste has potential for generating income from high-added-value compounds through fermentation. Solid-state fermentation is promising to obtain a high yield of bioactive compounds while requiring less water for the microorganism’s growth. A number of scientific studies evinced an increase in flavonoids or phenolics from fruit or vegetable waste and bioactive peptides from cereal processing residues and whey, a major waste of the dairy industry. Livestock, fish, or shellfish processing by-products (skin, viscera, fish scales, seabass colon, shrimp waste) also has the possibility of generating antioxidant peptides, hydrolysates, or compounds through fermentation. These bioactive compounds (phenolics, flavonoids, or antioxidant peptides) resulting from bacterial or fungal fermentation are also capable of inhibiting the growth of commonly occurring food spoilage fungi and can be used as natural preservatives. Despite the significant release or enhancement of antioxidant compounds through by-products fermentation, the surface areas of large-scale bioreactors and flow patterns act as constraints in designing a scale-up process for improved efficiency. An in-process purification method can also be the most significant contributing factor for raising the overall cost. Therefore, future research in modelling scale-up design can contribute towards mitigating the discard of high-added-value generating residues. Therefore, in this review, the current knowledge on the use of fermentation to obtain bioactive compounds from food by-products, emphasizing their use as natural preservatives, was evaluated.

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Mehta, Nitin, Pavan Kumar, Akhilesh K. Verma, Pramila Umaraw, Yogesh Kumar, Om Prakash Malav, Awis Qurni Sazili, Rubén Domínguez, and José M. Lorenzo. "Microencapsulation as a Noble Technique for the Application of Bioactive Compounds in the Food Industry: A Comprehensive Review." Applied Sciences 12, no. 3 (January 28, 2022): 1424. http://dx.doi.org/10.3390/app12031424.

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The use of natural food ingredients has been increased in recent years due to the negative health implications of synthetic ingredients. Natural bioactive compounds are important for the development of health-oriented functional food products with better quality attributes. The natural bioactive compounds possess different types of bioactivities, e.g., antioxidative, antimicrobial, antihypertensive, and antiobesity activities. The most common method for the development of functional food is the fortification of these bioactive compounds during food product manufacturing. However, many of these natural bioactive compounds are heat-labile and less stable. Therefore, the industry and researchers proposed the microencapsulation of natural bioactive compounds, which may improve the stability of these compounds during processing and storage conditions. It may also help in controlling and sustaining the release of natural compounds in the food product matrices, thus, providing bioactivity for a longer duration. In this regard, several advanced techniques have been explored in recent years for microencapsulation of bioactive compounds, e.g., essential oils, healthy oils, phenolic compounds, flavonoids, flavoring compounds, enzymes, and vitamins. The efficiency of microencapsulation depends on various factors which are related to natural compounds, encapsulating materials, and encapsulation process. This review provides an in-depth discussion on recent advances in microencapsulation processes as well as their application in food systems.

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McNab, Justin M., Jorge Rodríguez, Peter Karuso, and Jane E. Williamson. "Natural Products in Polyclad Flatworms." Marine Drugs 19, no. 2 (January 21, 2021): 47. http://dx.doi.org/10.3390/md19020047.

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Marine invertebrates are promising sources of novel bioactive secondary metabolites, and organisms like sponges, ascidians and nudibranchs are characterised by possessing potent defensive chemicals. Animals that possess chemical defences often advertise this fact with aposematic colouration that potential predators learn to avoid. One seemingly defenceless group that can present bright colouration patterns are flatworms of the order Polycladida. Although members of this group have typically been overlooked due to their solitary and benthic nature, recent studies have isolated the neurotoxin tetrodotoxin from these mesopredators. This review considers the potential of polyclads as potential sources of natural products and reviews what is known of the activity of the molecules found in these animals. Considering the ecology and diversity of polyclads, only a small number of species from both suborders of Polycladida, Acotylea and Cotylea have been investigated for natural products. As such, confirming assumptions as to which species are in any sense toxic or if the compounds they use are biosynthesised, accumulated from food or the product of symbiotic bacteria is difficult. However, further research into the group is suggested as these animals often display aposematic colouration and are known to prey on invertebrates rich in bioactive secondary metabolites.

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Widada, Jaka. "Discovery of novel bioactive natural products from Streptomyces driven by a bottom-up approach." BIO Web of Conferences 41 (2021): 02003. http://dx.doi.org/10.1051/bioconf/20214102003.

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Streptomyces strains are a very potential source for bioactive natural products of great interest in the pharmaceutical industry such as antibiotics, anticancer chemotherapy, immunosuppressants, etc. About two thirds of all known antibiotics are produced by actinomycetes, mostly by Streptomyces. However, in recent years, the chances of discovering new and bioactive natural products from Streptomyces have decreased significantly. In general, the selection of antibioticproducing Streptomyces was done by using an antagonist to test a number of microbial pathogens so that only strains that had the inhibitory ability were forwarded for further investigation, while strains that did not have the ability were discarded. For our research group, it is also interesting to explore furtherStreptomyces strains that do not produce antifungal compounds in producing new bioactive natural products such as anticancer and anti-inflammatory. Our hypothesis is that the bioactive natural products produced from this strain will be safe if the compound is developed as a drug, because of its low cytotoxicity to non-target cells. The bottom-up approach through genome sequencing has provided access to a large number of BGC bioactive natural products embedded in the Streptomyces genome. In addition, metabolomics studies provide a portfolio of the entire metabolite producedfrom the strain of interest. Therefore, in this presentation, we will present a bottomup approach to accelerate the discovery of bioactive natural products especially anticancer from Streptomyces sp. GMY01 isolated from the sediments of the southerncoast of Gunung Kidul, Yogyakarta by combining genomic mining and metabolomic approaches.

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Quintavalla, Arianna. "Spirolactones: Recent Advances in Natural Products, Bioactive Compounds and Synthetic Strategies." Current Medicinal Chemistry 25, no. 8 (March 16, 2018): 917–62. http://dx.doi.org/10.2174/0929867324666171106162259.

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Background: The spirocyclic compounds have always aroused a great interest because this motif is present as structural core in a number of natural products and bioactive compounds. In particular, the spirolactone moiety has been recognized in a wide array of natural and non-natural scaffolds showing a variety of useful pharmacological properties. Methods: Extensive literature search using SciFinder (Databases: CA Plus, CAS Registry, CAS React, Chemlist, Chemcat and Medline) and Web of Science (Database: Web of Science Core Collection) was conducted. Results: Nowadays, many efforts are being devoted to the discovery of new natural products containing the promising spirolactone framework and to the disclosure of the potential bioactivities of these chemical entities. Moreover, the medicinal relevance of many spirolactones makes these scaffolds attractive targets for the design and development of innovative and efficient synthetic strategies, enabling the construction of complex and variably substituted products. Conclusion: This review gives an overview on the recent advances in the spirolactones field, in terms of new compounds isolated from natural sources, recently determined bioactivity profiles and innovative synthetic approaches. The collected data demonstrate the key role played by spirolactones in medicinal chemistry and the great attention still devoted by the scientific community to these compounds.

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Jesumani, Valentina, Hong Du, Muhammad Aslam, Pengbing Pei, and Nan Huang. "Potential Use of Seaweed Bioactive Compounds in Skincare—A Review." Marine Drugs 17, no. 12 (December 6, 2019): 688. http://dx.doi.org/10.3390/md17120688.

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Modern lifestyles have developed new attention on appearance and personal care which attract a huge number of consumers towards cosmetic products. The demand for a skincare product with natural ingredients is rapidly increasing. Seaweeds are major resources for in-demand active compounds with a wide variety of applications. The use of seaweed-derived ingredients in cosmetic products has increased in recent years as many scientific studies have proved the potential skincare properties of seaweed bioactive compounds. This review emphasizes possible skincare properties of seaweed bioactive compounds. The review outlines the mechanism involved in skin problems including hyperpigmentation, premature skin aging, and acne in the first part while the second part focuses on the promising application of seaweeds in skin protection by highlighting the bioactive compound responsible for their bioactivity.

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Owusu-Dapaah, George, and Nicolas I. Y. Fiagbe. "Brine Shrimp Lethality Bioassay: A Tool for Drug Discovery from Natural Products." International Journal of Technology and Management Research 1, no. 2 (March 12, 2020): 40–48. http://dx.doi.org/10.47127/ijtmr.v1i2.22.

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This study demonstrates the importance of the Brine Shrimp Bioassay in drug discovery. It uses two medicinal plants, Zanthoxylum xanthoxyloides and Tiliacora funifera. Extracts of Zanthoxylum xanthoxyloides were prepared using water, ethanol, chloroform and diethylether, and each subjected to Brine Shrimp Bioassay. The bioactivities of the extracts were found to be in the order diethylether (LD50=0.958 mg/ml), followed by ethanol (LD50=1.874 mg/ml), water(LD50=2.322 mg/ml), and chloroform (3.518 mg/ml). From Tiliacora funifera is isolated the compound funiferine, which is derivatized to obtain o-methylfuniferine and o-isopropylfuniferine. These were subjected to the brine shrimp bioassay, and the structure –activity relationship (SAR) was determined. The results showed that o-isopropylfuniferine is the most bioactive (LD50 = 9.07 mg/ml), followed by o-methylfuniferine (LD50 =38 mg/ml) with funiferine showing the least activity (LD50 =50.25 mg/ml). The SAR of the compounds indicates that the activity of the compounds increases as the size of the group on the phenolic OH is increased, (i.e. isopropyl (C 3 H7 )> methyl (CH3 ) > hydrogen (H)), which suggests that bulkier groups may give more potent compounds. These two results show that the brine shrimp bioassay can be used as a tool in the search for more bioactive compounds from natural products. Keywords: Brine Shrimp Bioassay, Zanthoxylum xanthoxyloides, Funiferine; o-methylfuniferine,o-isopropylfuniferine.

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Hook, Derek J., Edward J. Pack, Joseph J. Yacobucci, and Jeffrey Guss. "Approaches to Automating the Dereplication of Bioactive Natural Products—The Key Step in High Throughput Screening of Bioactive Materials From Natural Sources." Journal of Biomolecular Screening 2, no. 3 (April 1997): 145–52. http://dx.doi.org/10.1177/108705719700200304.

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The rapid identification of the bioactive component(s) of natural product mixtures in high throughput screening programs has become a critical factor to ensure that this source of diverse chemotypes can compete effectively with chemical compound libraries and combinatorial synthetic efforts. The effective use of automated procedures and databases in the isolation, identification and biological profiling of bioactive compounds will be described. In addition, the potential of new technologies to enhance this process will be discussed as well as the possible reintroduction of TLC as a parallel dereplication method.

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Breza-Boruta, Barbara, Anna Ligocka, and Justyna Bauza-Kaszewska. "Natural Bioactive Compounds in Organic and Conventional Fermented Food." Molecules 27, no. 13 (June 24, 2022): 4084. http://dx.doi.org/10.3390/molecules27134084.

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Compared to conventional agriculture, organic farming is believed to provide a higher nutritional and health value in its products due to the elimination of harmful contaminants (pesticides, nitrates, heavy metals, etc.). Numerous studies have been conducted to show how the production system affects the quality of food in terms of the content of bioactive compounds. The aim of this study was to compare the content of some bioactive compounds (vitamin C, β-carotene, Ca content) and lactic acid bacteria (LAB) number and their bacteriocinogenic activity in organic and conventional fermented food. Although the results do not provide an unambiguous conclusion regarding the superiority of one production system over the other, the LAB number in organic pickled carrot juice, sauerkraut, yogurt, and kefir was higher than in their conventional counterparts. Their bacteriocinogenic potential against selected pathogens was also higher in most organic products. Organic vegetables contained significantly more vitamin C, and the calcium content in the organic yogurt was higher compared to the conventional version of the product. Relatively similar concentrations of ß-carotene for both production systems were found in carrot juice, while in organic pickled beet juice, there was five-fold less ß-carotene than in conventional juice.

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Salevic, Ana, Ana Kalusevic, Steva Levic, and Viktor Nedovic. "Encapsulation of bioactive compounds derived from fruit processing by-products." Journal of Agricultural Sciences, Belgrade 63, no. 2 (2018): 113–37. http://dx.doi.org/10.2298/jas1802113s.

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An increased environmental awareness has led to new trends in food industry, which are reflected in intensive studies on exploitation of fruit processing byproducts. Additionally, consumers? tendency to a healthy lifestyle has initiated the development of diverse functional food products. High amounts of by-products, such as peels, seeds, and stones, are discarded during fruit processing. It represents a problem both from the environmental and the economic point of view. On the other hand, the resulting residues are potential sources of numerous bioactive compounds. Therefore, fruit processing by-products such as substrates for the extraction of phenolic compounds, natural pigments, dietary fibers, protein isolates and oils attract great interest. These extracts have a great potential for the development of dietary supplements and new functional food products with beneficial health effects. However, bioactive compounds are susceptible to degradation, which represents a critical factor for their successful incorporation into food products. In this regard, the main challenge is to ensure the stability of bioactive compounds during processing, storage and in the gastrointestinal tract, i.e. to preserve their bioactivity and bioavailability. This challenge could be accomplished by the use of encapsulation. Namely, the formation of a physical barrier between an active compound and its surrounding is an effective way of protection. The present paper indicates the potential of by-products originating from the processing of apples, grapes, plums, raspberries and sour cherries as sources of bioactive compounds. It also points out the benefits that could be achieved by the encapsulation of bioactive compounds extracted from fruit processing by-products in order to develop new functional food products.

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Saide, Assunta, Sara Damiano, Roberto Ciarcia, and Chiara Lauritano. "Promising Activities of Marine Natural Products against Hematopoietic Malignancies." Biomedicines 9, no. 6 (June 5, 2021): 645. http://dx.doi.org/10.3390/biomedicines9060645.

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According to the WHO classification of tumors, more than 150 typologies of hematopoietic and lymphoid tumors exist, and most of them remain incurable diseases that require innovative approaches to improve therapeutic outcome and avoid side effects. Marine organisms represent a reservoir of novel bioactive metabolites, but they are still less studied compared to their terrestrial counterparts. This review is focused on marine natural products with anticancer activity against hematological tumors, highlighting recent advances and possible perspectives. Until now, there are five commercially available marine-derived compounds for the treatment of various hematopoietic cancers (e.g., leukemia and lymphoma), two molecules in clinical trials, and series of compounds and/or extracts from marine micro- and macroorganisms which have shown promising properties. In addition, the mechanisms of action of several active compounds and extracts are still unknown and require further study. The continuous upgrading of omics technologies has also allowed identifying enzymes with possible bioactivity (e.g., l-asparaginase is currently used for the treatment of leukemia) or the enzymes involved in the synthesis of bioactive secondary metabolites which can be the target of heterologous expression and genetic engineering.

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Mohd Sairazi, Nur Shafika, and K. N. S. Sirajudeen. "Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases." Evidence-Based Complementary and Alternative Medicine 2020 (February 14, 2020): 1–30. http://dx.doi.org/10.1155/2020/6565396.

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In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

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Tremocoldi, Maria Augusta, Pedro Luiz Rosalen, Marcelo Franchin, Adna Prado Massarioli, Carina Denny, Érica Regina Daiuto, Jonas Augusto Rizzato Paschoal, Priscilla Siqueira Melo, and Severino Matias de Alencar. "Exploration of avocado by-products as natural sources of bioactive compounds." PLOS ONE 13, no. 2 (February 14, 2018): e0192577. http://dx.doi.org/10.1371/journal.pone.0192577.

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Fu, Yanwei, Jiaoyang Luo, Jiaan Qin, and Meihua Yang. "Screening techniques for the identification of bioactive compounds in natural products." Journal of Pharmaceutical and Biomedical Analysis 168 (May 2019): 189–200. http://dx.doi.org/10.1016/j.jpba.2019.02.027.

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Gomez, Catherine, Jean-François Betzer, Arnaud Voituriez, and Angela Marinetti. "Phosphine Organocatalysis in the Synthesis of Natural Products and Bioactive Compounds." ChemCatChem 5, no. 5 (October 12, 2012): 1055–65. http://dx.doi.org/10.1002/cctc.201200442.

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Laranjeira, Tânia, Ana Costa, Catarina Faria-Silva, Daniela Ribeiro, José Miguel P. Ferreira de Oliveira, Sandra Simões, and Andreia Ascenso. "Sustainable Valorization of Tomato By-Products to Obtain Bioactive Compounds: Their Potential in Inflammation and Cancer Management." Molecules 27, no. 5 (March 4, 2022): 1701. http://dx.doi.org/10.3390/molecules27051701.

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Tomato producing and processing industries present undoubted potential for industrial discarded products valorization whether due to the overproduction of fresh tomatoes or to the loss during processing. Although tomato by-products are not yet considered a raw material, several studies have suggested innovative and profitable applications. It is often referred to as “tomato pomace” and is quite rich in a variety of bioactive compounds. Lycopene, vitamin C, β-carotene, phenolic compounds, and tocopherol are some of the bioactives herein discussed. Tomato by-products are also rich in minerals. Many of these compounds are powerful antioxidants with anti-inflammatory properties besides modulating the immune system. Several researchers have focused on the possible application of natural ingredients, especially those extracted from foods, and their physiological and pharmacological effects. Herein, the effects of processing and further applications of the bioactive compounds present in tomato by-products were carefully reviewed, especially regarding the anti-inflammatory and anti-cancer effects. The aim of this review was thus to highlight the existing opportunities to create profitable and innovative applications for tomato by-products in health context.

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Munekata, Paulo E. S., Mirian Pateiro, Rubén Domínguez, Gema Nieto, Manoj Kumar, Kuldeep Dhama, and José M. Lorenzo. "Bioactive Compounds from Fruits as Preservatives." Foods 12, no. 2 (January 11, 2023): 343. http://dx.doi.org/10.3390/foods12020343.

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The use of additives with preservative effects is a common practice in the food industry. Although their use is regulated, natural alternatives have gained more attention among researchers and professionals in the food industry in order to supply processed foods with a clean label. Fruits are essential components in a healthy diet and have also been associated with improved health status and a lower risk of developing diseases. This review aims to provide an overview of the main bioactive compounds (polyphenols, betalain, and terpenes) naturally found in fruits, their antioxidant and antimicrobial activity in vitro, and their preservative effect in different foods. Many extracts obtained from the skin (apple, grape, jabuticaba, orange, and pomegranate, for instance), pulp (such as red pitaya), and seeds (guarana, grape, and jabuticaba) of fruits are of great value due to the presence of multiple compounds (punicalagin, catechin, gallic acid, limonene, β-pinene, or γ-terpinene, for instance). In terms of antioxidant activity, some fruits that stand out are date, jabuticaba, grape, and olive, which interact with different radicals and show different mechanisms of action in vitro. Antimicrobial activity is observed for natural extracts and essential oils (especially from citrus fruits) that limit the growth of many microorganisms (Bacillus subtilis, Escherichia coli, Penicillium digitatum, and Pseodomonas aeruginosa, for instance). Studies in foods have revealed that the use of extracts or essential oils as free or encapsulated forms or incorporated into films and coatings can inhibit microbial growth, slow oxidative reactions, reduce the accumulation of degradative products, and also preserve sensory attributes, especially with films and coatings. Future studies could focus on the advances of extracts and essential oils to align their use with the development of healthier foods (especially for meat products) and explore the inhibition of spoilage microorganisms in dairy products, for instance.

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Journal articles on the topic 'Natural products and bioactive compounds'

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