Relevant bibliographies by topics / Natural products

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Natural products'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 August 2024

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Journal articles on the topic "Natural products"

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ANB, Singab. "Bioavailability of Natural Products." Bioequivalence & Bioavailability International Journal 3, no. 1 (January 4, 2019): 1–2. http://dx.doi.org/10.23880/beba-16000137.

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First Komen, Ivana, and Nina Grgurić Čop. "Naturally traditional or traditionally natural – exploring the concepts natural and traditional in marketing research." Zbornik radova Ekonomskog fakulteta u Rijeci: časopis za ekonomsku teoriju i praksu/Proceedings of Rijeka Faculty of Economics: Journal of Economics and Business 40, no. 1 (June 30, 2022): 225–46. http://dx.doi.org/10.18045/zbefri.2022.1.225.

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The purpose of this research is to understand how current marketing research conceptualises natural and traditional products – products that strongly attract consumer attention and capture large and growing market shares yet remain vague and weakly defined by a regulatory framework. The analysis is conducted on systematically selected research articles published in relevant journals over the past two decades. The results show that the natural products are mostly defined by the way they are produced and the ingredients they do not contain, while no consensus was reached for the traditional products. Furthermore, not only is the concept of traditional defined by an unusually large number of themes, but the themes also vary considerably depending on stakeholder group from which they originate, indicating an inevitable communication problem between these groups. The results also show that despite attempts by marketers to link the meanings of the two types of products, the themes in the definitions of natural and traditional products are different and overlap only sporadically. These findings serve as a step toward creating better academic conceptualizations and a more specific regulatory framework for natural and traditional products that will reduce the likelihood of misleading business practises and confusion among consumers and researchers.
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Hamann, Mark. "Natural Products and Climate Change." Tropical Journal of Natural Product Reseach 1, no. 2 (August 9, 2017): 47–48. http://dx.doi.org/10.26538/tjnpr/v1i2.1.

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Helmi, Yousif Alfarra, and Nor Omar Muhammad. "Microbial Transformation of Natural Products." Greener Journal of Biological Sciences 3, no. 10 (December 13, 2013): 357–64. http://dx.doi.org/10.15580/gjbs.2013.10.112913995.

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Goldman, Ran D., Alex L. Rogovik, David Lai, and Sunita Vohra. "Potential Interactions of Drug–Natural Health Products and Natural Health Products–Natural Health Products among Children." Journal of Pediatrics 152, no. 4 (April 2008): 521–26. http://dx.doi.org/10.1016/j.jpeds.2007.09.026.

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Carroll, Anthony R., Brent R. Copp, Rohan A. Davis, Robert A. Keyzers, and Michèle R. Prinsep. "Marine natural products." Natural Product Reports 38, no. 2 (2021): 362–413. http://dx.doi.org/10.1039/d0np00089b.

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Sherman, Carol, and Allen Sherman. "Natural Products Industry." Business Ethics: The Magazine of Corporate Responsibility 11, no. 2 (1997): 20–21. http://dx.doi.org/10.5840/bemag199711225.

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Heard, Stephanie C., Guangwei Wu, and Jaclyn M. Winter. "Antifungal natural products." Current Opinion in Biotechnology 69 (June 2021): 232–41. http://dx.doi.org/10.1016/j.copbio.2021.02.001.

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Nogueira, Cláudio R., and Lucia M. X. Lopes. "Antiplasmodial Natural Products." Molecules 16, no. 3 (March 4, 2011): 2146–90. http://dx.doi.org/10.3390/molecules16032146.

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Eldahshan, Omayma. "Hepatoprotective Natural Products." Archives of Pharmaceutical Sciences Ain Shams University 1, no. 2 (July 1, 2017): 46–47. http://dx.doi.org/10.21608/aps.2017.11027.

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Dissertations / Theses on the topic "Natural products"

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Bringans, Scott D. "Studies on natural product derivatives : HIV therapies incorporating marine natural products." Thesis, University of Canterbury. Chemistry, 2001. http://hdl.handle.net/10092/6699.

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CV-N is an 11 kDa, anti-HIV protein that binds strongly to the envelope glycoprotein, gp120, expressed on the outer surface of the free virion and also on HIV-infected cells. As such, it represents an important lead for development of anti-HIV therapeutics. Marine toxins such as the halichondrins have potent in vivo cytotoxicities and are lethal to cells. The combination of this potency of the marine toxins with the unique targeting capability of CV-N has been harnessed to produce conjugates that have the potential to selectively target and eliminate HIV-infected cells. Three forms of the protein were developed; the native protein itself, a derivative recombinantly produced in E. coli with an extra cysteine at the C-terminal (CV-N-Cys) and CV-N with the lysine side chain amines converted into thiols (thiolated-CV-N). To facilitate release of the toxin within infected cells an enzymatically-cleavable pHdependent biolinker was incorporated separating the toxin from the protein. The chemistry required for incorporation of protein, biolinker, and toxin, was established through synthesis of fluorescently labelled conjugates capable of reaction with CV-N. Biological testing of these derivatives showed no interference with the anti-HIV activity of the CV-N when conjugated in these model compounds. Synthetic strategies were developed to produce two derivatives of norhomohalichondrin B amine, both containing the cleavable biolinker, but with activation from succinimidyl esters and maleimido groups respectively. Native CV-N was reacted with the succinimidyl ester derived toxin construct to produce a CV-N-biolinker-toxin conjugate. The maleimido derivative toxin construct was reacted with both CV-N-Cys and thiolated-CV -N to produce closely related CV-N-toxin conjugates. Investigations into the binding properties and cell toxicities of these conjugates is currently underway.
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Aguilar, Aguinaga Rodrigo, Torres Alexander César Enrique Alva, Esquivel Karla Paola Bernedo, Deza Jhoselyn Lucia Nicole Gomez, and Melgarejo Michael Richard Ganoza. "Shampoo Sólido Natural: Pashoo." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/651789.

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Pashoo es una empresa que se creó gracias a la idea de cinco estudiantes que se encuentran cursando el décimo ciclo en la Universidad Peruana de Ciencias Aplicadas (UPC), la cual está orientada a la industria de cuidado de belleza y salud mediante la fabricación y comercialización de shampoo en barra 100% naturales a base de ingredientes seleccionados de acuerdo con sus valores nutricionales que estos le brindan al cabello. Contamos con shampoos de distintos olores y para todo tipo de cabellos como por ejemplo shampoo a base de aceite de jojoba, coco, almendras, argán y palta combinados con esencias naturales que le brindan al cliente una sensación de relajación. Por otro lado, hemos segmentado a nuestros clientes de manera que nuestro producto pueda solucionar sus problemas. Para este proyecto, nos estamos fijando en las mujeres que tienen problemas de caída de cabello e irritación en el cuero cabelludo y que estén buscando productos orgánicos y naturales que tengan conciencia sobre el cuidado del medio ambiente. Vamos a distribuir nuestros productos mediante ferias y por delivery utilizando como canales de comunicación las redes sociales y nuestra página web en donde los clientes podrán encontrar información necesaria sobre nosotros y nuestros productos. De la misma forma, mostrar las validaciones del modelo de negocio, el desarrollo del negocio, el plan financiero y de marketing, así como las operaciones que se realizaron a lo largo de este proyecto dejando por último nuestras conclusiones y recomendaciones por la realización del proyecto de negocio.
Pashoo is a company that was created thanks to the idea of five students who are studying the tenth cycle at the Universidad Peruana de Ciencias Aplicadas (UPC), which is oriented to the beauty and health care industry through manufacturing and marketing 100% natural bar shampoo based on selected ingredients according to their nutritional values that they provide to the hair. We have shampoos of different scents and for all types of hair such as jojoba oil, coconut, almond, argan and avocado shampoo combined with natural essences that give the client a feeling of relaxation. On the other hand, we have segmented our customers so that our product can solve their problems. For this project, we are looking at women who have problems with hair loss and irritation on the scalp and who are looking for organic and natural products that are aware of the care of the environment. We will distribute our products through fairs and by delivery using social media and our webpage as communication channels where customers can find necessary information about us and our products. In the same way, show the validations of the business model, the development of the business, the financial and marketing plan, as well as the operations that were carried out throughout this project, finally leaving our conclusions and recommendations for the completion of the project of business.
Trabajo de investigación
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Woods, Katherine B. "Bioactive natural products." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/26234.

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Montbretins A-E were isolated from the corms of Crocosmia sp., an invasive perennial plant. The montbretins are inhibitors of human pancreatic α-amylase (HPA). Montbretin A (2- 30) is a competitive inhibitor of HPA with a K₁ of 1.3 nM. The activity of the other family members varied significantly and provided structure-activity information. Saturation Transfer Difference (STD) NMR spectroscopy was used to determine that the caffeic acid region of the montbretins is important for binding. HPA is involved in the breakdown of complex carbohydrates; inhibition of this enzyme could help with regulation of blood sugar levels after a meal. In the lungs of cystic fibrosis patients, the activation of Toll-Like Receptor 5 (TLR5) in the presence of flagellin leads to inflammation and obstruction. Girolline (3-1), a known alkaloid, was isolated from a Phonpeian sponge following potent inhibition of the flagellin initiated TLR5 activation. No activity was observed in any synthetic analogues of girolline. The massacreones are a new family of ecdysteroids isolated from an unidentified Dominican cnidarian. The extract of the cnidarian had good TLR5 activity, but the massacreones – namely massacreone A (3-25) and massacreone B (3-26) have only moderate activity and a small window of activity before they are toxic. The algal pigment caulerpin (4-29) was isolated from Caulerpa sp. as a compound showing good activity in a yeast growth restoration assay designed to identify inhibitors ofhuman indoleamine-2,3-dioxygenase (IDO). Caulerpin did not show any activity in a free enzyme IDO assay. IDO is involved in immune escape, which prevents the immunological rejection of tumors.
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Desjardine, Kelsey Lorne. "Bioactive marine natural products." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31286.

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The chemical exploration of extracts from cultures of the marine bacterial isolate PNG-276 yielded the novel antibiotic tauramamide (2.13), a non-ribosomal peptide active against cultures of Enterococcus sp. and methicillin-resistant Staphylococcus aureus (MRSA). A study of extracts of the marine sponge Spirastrella coccinea yielded the novel macrolide methylspirastrellolide C (3.14), which is active against protein phosphatase 2A (PP2A). A third study examined sponge extracts active in a cannabinoid receptor assay, yielding two known compounds, an A- nor -steroid derivative (4.10) and bengamide A (4.11). Neither purified compound was active in the cannabinoid receptor assay, although in both cases this is the first report of these compounds being isolated from Stylissa massa and Hemiasterella aff. affinis sponges, respectively. [See Thesis for Diagrams]
Science, Faculty of
Chemistry, Department of
Graduate
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Dagli, Selma. "Studies in natural products." Thesis, University of Glasgow, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392427.

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Tele, Chhagan Godha. "Studies in natural products." Thesis, University of Aberdeen, 1987. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU539757.

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The first chapter of this thesis deals with some substitution reactions of -carbolines aimed at the synthesis of the metabolite 6-hydroxyharmine which is produced when harmine is incubated with rat liver microsomes. The conversion of 6-bromo- and 6-nitro-harmine into its hydroxy-analogue was not achieved but direct hydroxylation of harmine using lead tetra-acetate trifluoroacetic acid followed by in situ reduction with zinc dust gave 6-hydroxyharmine. This reaction also worked with harman and norharman. In the second chapter, the synthesis of 4-aryl-5,2'-oxido-coumarins has been carried out by oxidative coupling, using dichloro-dicyanobenzo-quinone or potassium ferricyanide on methoxy- or hydroxy-4-phenylcoumarins. Our synthesis of 4',5'-dihydroxy-7-methoxy-4-phenyl-5,2'-oxido-coumarin confirmed that one of the natural products isolated from Coutarea latiflora was indeed an oxido-coumarin. The third chapter examines the corrosion inhibitive properties on mild steel of naturally occurring organic compounds and their derivatives. Mono- and di-sodium salts of carboxylic acids, amino-acids, lignins, tannins and humic acids and extracts of the plants Crtisus scoparius (broom), Calluna vulgaris (heather), Pteridium aquilinum (fern), the seaweeds Fucus ceranoides and Pelvetia canaliculata and mussels Mytilus edulis all show indhibitor properties. An assessment of their relative efficiencies has also been made. The last part of this chapter discusses the corrosion inhibitive properties of oxidation products derived from castor and olive oils.
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Laguna, Egea Juan Carlos. "Acción farmacológica a nivel hepático de los derivados polifenólicos de Cynara scolymus L." Doctoral thesis, Universitat de Barcelona, 1986. http://hdl.handle.net/10803/673012.

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El hígado, por su especial disposición anatómica, recibe directamente la mayoría de sustancias asimiladas por el organismo, lo que hace que se encuentre expuesto a la agresión de aquellos compuestos potencialmente tóxicos. Si bien los hepatocitos disponen de sistemas metabólicos capaces de degradar y neutralizar los xenobióticos, el número de estos es extremadamente amplio. No sólo se encuentran en este capítulo fármacos como el paracetamol, la clorpromacina y otros, sino todos aquellos contaminantes que, voluntaria o involuntariamente, se ingieren con cierta asiduidad. Por todo ello, la incidencia de las afecciones hepáticas de origen tóxico es cada vez más acusada. Su etiología poco definida implica un tratamiento, en la mayoría de los casos, sintomático. El descubrimiento de la silimarina y otros principios de origen natural, ha abierto una vía de esperanza en la solución de esta casuística. Aunque es cierto que existe un grado de escepticismo con respecto a sus posibilidades cura tivas, es innegable que estos compuestos conjugan una clara acción farmacológica con una mínima toxicidad. Desde hace unos años, el Departamento de Farmacognosia y Farmacodinamia de la Facultad de Farmacia de Barcelona, investiga la actividad hepatoprotectora de compuestos polifenólicos de origen natural, en la creencia de que el estudio de las propiedades de estas sustancias permitirá el mejor conocimiento de los mecanismos biológicos implicados de la patología hepática, base de la futura instauración de una terapéutica eficaz. El hecho de que se escogiera como sujeto del presente estudio la alcachofa (Cynara scolymus L.) radica en que, a pesar de su destacada actividad colerética, no se ha demostrado de forma precisa si esta droga presenta o no propiedades hepatoprotectoras. Del mismo modo, no queda claro el papel que desempeñan los derivados polifenólicos y, específicamente, los cafeilquínicos de la alcachofa. Se ha trabajado con sustancias polifenólicas puras y con extractos de alcachofa caracterizados por técnicas de HPLC, a fin de poder relacionar las actividades detectadas con un determinado principio o grupo de ellos.
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Dorel, Bruscas Ruth. "New annulation strategies: from polycyclic aromatic hydrocarbons to natural products." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/401589.

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Aquesta Tesi Doctoral cobreix tres camps de la química orgànica sintètica dedicats a la síntesi de nous materials basats en hidrocarburs aromàtics policíclics (HAPs), el desenvolupament de noves metodologies sintètiques catalitzades per complexos metàl·lics, i la síntesi de derivats de productes naturals. El desenvolupament de noves estratègies per a la síntesi de nous fragments de grafè amb estructures ben definides és un camp de gran interès donada la seva potencial implementació en dispositius d’electrònica molecular. Els fragments de grafè amb estructures circulars resulten particularment interessants degut a les seves extraordinàries propietats optoelectròniques i d’autoassemblatge. En aquest context es va desenvolupar la síntesi d’un nou fragment circular de grafè d’elevada simetria C54H20, tetrabenzocircumpirè, les propietats electròniques del qual van ser examinades mitjançant microscòpia d’efecte túnel (STM). Els acens estan constituïts per anells de benzè fusionats en línia i representen un atractiu tipus de HAPs degut a les seves propietats semiconductores. Tanmateix, la seva aplicació en dispositius electrònics està limitada per la seva baixa solubilitat i la seva inherent inestabilitat. Una possible solució per salvar aquestes limitacions és preparar derivats parcialment saturats més estables, els quals poden emprar-se com precursors dels sistemes conjugats. Així doncs, va establir-se un nou mètode per a la preparació d’acens parcialment saturats basat en una ciclació catalitzada per or(I) d’1,7-enins que deriven d’un precursor comú. Aquest mètode va resultar ser general i va permetre la preparació de diversos dihidrotetracens funcionalitzats, així com d’hidroacens amb fins a nou anells linealment fusionats. L’excepcional habilitat dels complexos d’or(I) per a construir estructures policícliques complexes va ser examinada també en el marc de la síntesi de productes naturals. L’alcoxiciclació d’1,6-enins catalitzada per or(I) va permetre un ràpid assemblatge de l’esquelet tetracíclic [3,5,5,7] de les echinopines, fet què va donar lloc a un mètode per a la preparació de derivats funcionalitzats d’aquests productes naturals.
Esta Tesis Doctoral cubre tres campos de la química orgánica sintética dedicados a la síntesis de nuevos materiales basados en hidrocarburos aromáticos policíclicos (HAPs), el desarrollo de nuevas metodologías sintéticas catalizadas por complejos metálicos, y la síntesis de derivados de productos naturales. El desarrollo de nuevas estrategias para la síntesis de nuevos fragmentos de grafeno con estructuras bien definidas es un campo de gran interés dada su potencial implementación en dispositivos de electrónica molecular. Los fragmentos de grafeno con estructuras circulares resultan particularmente interesantes debido a sus extraordinarias propiedades optoelectrónicas y de autoensamblaje. En este contexto se desarrolló la síntesis un nuevo fragmento circular de grafeno de elevada simetría C54H20, tetrabenzocircumpireno, cuyas propiedades electrónicas fueron examinadas mediante microscopía de efecto túnel (STM). Los acenos están constituidos por anillos de benceno fusionados en línea, y representan otra atractiva clase de HAPs debido a sus propiedades semiconductoras. Sin embargo, su aplicación en dispositivos electrónicos está limitada por su baja solubilidad y su inherente inestabilidad. Una posible solución para salvar estas limitaciones es preparar derivados parcialmente saturados más estables, los cuales pueden usarse como precursores de los sistemas conjugados. Así, se estableció un nuevo método para la preparación de acenos parcialmente saturados, el cual está basado en una ciclación catalizada por oro(I) de 1,7-eninos que derivan de un precursor común. Este método resultó ser general y permitió la preparación de diversos dihidrotetracenos funcionalizados, así como de hidroacenos con hasta nueve anillos linealmente fusionados.
This PhD covers three fields of synthetic organic chemistry devoted to the synthesis of new materials based on polycyclic aromatic hydrocarbons (PAHs), the development of new metal-catalyzed synthetic methodology, and the synthesis of natural product derivatives. The development of new strategies for the precise synthesis of structurally well-defined novel graphene cutouts is a field of great interest due to their potential implementation in molecular electronic devices. Particularly interesting PAHs are disc-shaped fragments of graphene because of their unique optoelectronic and self-assembly properties, which are predicted to be enhanced for expanded systems. In this context, an efficient synthesis of a new discotic highly symmetric C54H20 graphene fragment – tetrabenzocircumpyrene – was developed and the electronic properties of this new graphene fragment were examined by scanning tunneling microscopy (STM). Acenes consist of planar sets of linearly fused benzene rings and represent another appealing class of PAHs due to their semiconducting properties. Nonetheless, their applicability in electronic devices is limited by their poor solubility and their inherent instability. One approach to circumvent these limitations is the preparation of more stable partially saturated derivatives, which can be used as precursors of the conjugated systems. Thus, a selective method for the preparation of partially saturated acenes under mild reaction conditions was developed based on a gold(I)-catalyzed cyclization of suitable 1,7-enynes that were assembled from a common precursor. The method proved to be general and allowed the preparation of functionalized dihydrotetracenes, as well as larger hydroacenes with up to nine linearly fused rings. The outstanding ability of gold(I) complexes to construct complex polycyclic frameworks was also examined in the context of the synthesis of natural products. Thus, the gold(I)-catalyzed alkoxycyclization of cyclopropyl-tethered 1,6-enynes allowed the ready assembly of the [3,5,5,7] tetracyclic skeleton of Echinopines, which opened an entry for the preparation of functionalized derivatives of these natural products.
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Azzouz, Mariam. "Enantioselective synthesis of natural products." Doctoral thesis, Universitat Rovira i Virgili, 2013. http://hdl.handle.net/10803/365571.

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El objetivo general del trabajo presentado es investigar nuevas metodologías para la síntesis de: a) nectrisina, un inhibidor de α-glucosidasas y α-mannosidasas, b) del fragmento oligosacarídico del antibiótico AT2433-A1, un antibiótico utilizado en el tratamiento de numerosos tipos de cánceres y, c) de análogos del cidofovir o HPMPC, nucleósido acíclico que incorpora una unidad de fosfonato, y que se utiliza en el tratamiento del citomegalovirus (CMV) en pacientes con SIDA. Síntesis enantioselectiva de nectrisina Retrosintéticamente la síntesis de la nectrisina puede llevarse a cabo por ciclación del aminoaldehído 2 (R4=CHO), el cual puede proceder del alqueno trans 3 mediante una reacción de dihidroxilación estereoselectiva. La síntesis de 3 puede llevarse a cabo a partir de 4 mediante elongación de la cadena utilizando la reacción de metatesis cruzada catalizada por rutenio. Finalmente, el intermedio clave 4 procede de una aminación alílica asimétrica catalizada por Pd del monepóxido de butadieno racémico 5, reacción ya descrita por Trost. La aminación alílica asimétrica del monepóxido de butadieno racémico catalizada por Pd (η3-C3H5)PdCl/DACH-naftilo transcurrió con elevado rendimiento y enantioselectividad para dar el compuesto 4. La elongación de la cadena de 4 se realizó mediante una metatesis cruzada catalizada por el catalizador de Grubbs-Hoveyda con diferentes alquenos como acroleína, 2-vinil-1,3-dioxolano, y con acrilato de etilo. Sólo en este último caso se obtuvieron resultados relevantes del compuesto 3 (R4=COOEt) como para continuar la síntesis. La reacción de dihidroxilación estereoselectiva del alqueno trans 3 (R4=COOEt) condujo al diol deseado 2 (R4=COOEt) con buena selectividad utilizando OsO4/TMEDA. La hidrólisis del benzoato con LiOH y la ciclación in situ condujo a la lactama, a partir de la cual se siguió una secuencia sintética descrita en la bibliografía, consistente en la sililación de los grupos hidroxilo, protección del grupo amino en forma de terc-butil carbamato, reducción del carbonilo y eliminación con desprotección concomitante de los grupo sililo para dar la imina, que en nuestras manos no logró llevarse a fin debido a problemas en la última etapa de eliminación para dar la imina. Síntesis enantioselectiva de análogos de Cidofovir HPMPC La síntesis de los análogos del cidofovir se planteó siguiendo un esquema sintético similar al de la nectrisina, en el que la síntesis del intermedio 7 se llevó a cabo mediante la aminación alílica asimétrica del monoepóxido del butadieno y posterior reacción de metátesis cruzada como pasos clave. En primer lugar se realizó la aminación alílica asimétrica catalizada por Pd (η3-C3H5)PdCl/DACH-naftil del monepóxido de butadieno racémico, con adenina y citosina la cual se optimizó hasta conseguir rendimientos y excesos enantioméricos superiores al 90%. Seguidamente se optimizó la reacción de metátesis cruzada de los compuestos obtenidos (6) con un alil fosfonato convenientemente protegido, obteniendo 7 con buen rendimiento. La síntesis de los análogos de cidofovir insaturados 8 y 9 se completó tras la desprotección de todos los grupos protectores con TMSBr. La síntesis del derivado saturado 10 se realizó mediante la hydrogenación (3 bares de hidrógeno, Pd/C durante 5h) y la eliminación de los grupos protectores. Síntesis enantioselectiva del fragmento oligosacarídico del antibiótico AT2433-A1 La retrosíntesis de 18 se planteó por ciclación electrófila inducida por yodo de 15, donde X debiera ser un grupo activador del doble enlace que a su vez se pudiera comportar como grupo saliente en la subsiguiente reacción de glicosilación a partir de 15. La síntesis del intermedio 15 se planteó por diferentes procedimientos y en particular a partir del sulfato 14, el cual provendría del diol 13, que a su vez provendría de la dihidroxilación de 12. El compuesto 12 debería poder obtenerse a partir de 5 por la secuencia clásica de DYKAT y metatesis cruzada. Así, a partir del compuesto 11 (R=Boc) se realizó la metatesis cruzada con diferentes alquenos y en particular con el alil fenil tioéter. Las limitaciones se encontraron en la reacción de dihidroxilación, ya que en casi todos los casos ensayados se produjo la oxidación del azufre, lo que conduciría al cambio de la selectividad en posteriores etapas como la ciclación. Se consiguió evitar la oxidación utilizando ligandos quirales en la dihidroxilación, pero con rendimientos muy bajos no compatibles con un esquema de síntesis por etapas.
The present thesis deals with the development of methodology for the syntheses of several organic molecules that were selected by their interesting biological properties: the antibiotic AT2433-A1, the glycosidase inhibidor nectrisine and analogs of the anti-viral Cidofovir (Figure 1.1) . Although apparently structurally unrelated, they were envisaged to be synthesized through common high-efficient key steps that involve metal-catalyzed process. Enantioselective Synthesis of nectrisine We explore an enantioselective synthesis of nectrisine based on Pd-catalyzed asymmetric allylic amination, cross-metathesis and dihydroxylation as key steps. Scheme 1 shows the retrosynthesis proposed, where the key synthon is the allylamine 4 which is obtained in high enantiomeric purity by a deracemization process using Pd/DACH as a catalytic system. Cross-metathesis will allow increasing the chain length, and at the same time would provide the aldehyde functionality necessary for formation of the cyclic imine moiety in the final nectrisine. Besides, configuration of double bond resulting from cross-metathesis must be E in order to provide the correct configuration of hydroxyl groups in 2 after the dihydroxylation reaction. The stereoselectivity of this reaction will be controlled by the stereocenter in the molecule, which could be also be enhanced by chiral ligands in a matched double stereodifferentiation process. The asymmetric allylic amination from racemic butadiene monoepoxide using (η3-C3H5)PdCl/DACH-naphtyl system and t-Butyl-benzoyl-imido carboxylate as a N-nucleophile proceeded with excellent yield (98%) and enantioselectivity (97%) to obtain the chiral allylic amine synthon 4. Elongation of the chain of the key chiral allylic imide with ethyl acrylate through cross metathesis using Hoveyda-Grubbs catalyst (5 mol %), proceeded quatitatively to obtain the trans alkene intermediates 3. The installation of the syn diol moiety via dihydroxylation of the alkene proceeded with high yield and good diastereoselectivity with OsO4/TMEDA. Hydrolysis of benzoate group in 2 with LiOH and in situ cyclization led to the lactam. Whose hydroxyl functionalities were fully protected by treatment with TBSCl. Subsequent protection with di-t-butyl dicarbonate (Boc) 2O and Et3N in CH2Cl2 gave desired product in 50% yield. The increased carbonyl electrophilicity resulting from NBoc protection should facilitate the smooth reduction of the lactam, which proceeded by reaction with Super Hydride® at −78°C to give lactol. Enantioselective Synthesis of Cidofovir Analogues In this context, the retrosynthetic proposal is shown in Scheme 2. Cidofovir (HPMPC) analogues could be obtained by double bond reduction of product 7 followed by protecting group cleavage on compound 11. Compound 7 in turn can be synthesized from compound 6 via chain elongation mediated by cross-metathesis reaction. Lastly, chiral synthon 6 could be obtained by a palladium-catalyzed dynamic kinetic asymmetric transformation (DYKAT) from racemic butadiene monoepoxide (5). The asymmetric allylic amination of racemic butadiene monoepoxide with cytosine as N-nucleophile was carried out with (η3-C3H5)PdCl/DACH-naphtyl system to obtain chiral allylic cytosine in 85% yield and 72% ee. The reaction was successfully expanded to other pyrimidine and purine bases, among which adenine afforded chiral allyl adenine in 90% yield and 92% ee. Chain elongation via Ru-cross metathesis of key allylic nucleobases and diethyl allylphosphonate with second generation Grubbs catalyst (5 mol%), produced desired compounds in 92% and 90% yield, respectively. Deprotection of all protecting groups with TMSBr afforded the desired unsaturated acyclic nucleosides 8 and 9 in good yields. Hydrogenation with (H2, /Pd/C) at 3 bar rendered the saturated Cidifovir analogues 10. Approaches to the Enantioselective Synthesis of AT2433-A1 The objective of this work was to explore a new enantioselective method to obtain AT2433-A1 with special focus on the synthesis of the 2, 4-dideoxy-4-amino-xyloside moiety. The retrosynthetic proposal is shown in Scheme 5.6. The aminodeoxysugar (19) could be obtained from 16 by eletrophile-induced cyclization. A key point is the selection of group X, since it must control the regioselectivity of the cyclization to an endo-mode and eventually must behave as a leaving group in a future glycosylation reaction. Amino alcohol 16 could be prepared from allylic amine 13 by dihydroxylation, sulphate formation and elimination. Compound 13 can be synthesized from allyl amine 12 via chain elongation mediated by cross-metathesis reaction. Lastly, chiral allyl amine 12 could be obtained, similarly to the previous chapters, by a palladium-catalyzed dynamic kinetic asymmetric transformation (DYKAT) from the racemic butadiene monoepoxide 5. On the other hand, the intermediate 15 could be also obtained by addition to the Garner aldehyde (18) followed by deprotection of the protecting groups in 17. The asymmetric allylic amination from racemic butadiene monoepoxide using (η3-C3H5)PdCl/DACH-naphtyl system and imide as a nitrogen nucleophile proceeded with good yield (96%) and enantioselectivity (90%). Chain elongation of key chiral allylic amine 12 was carried out by cross metathesis with allyl phenyl sulphide with Hoveyda-Grubbs catalyst (5 mol%) to obtain the corresponding trans alkene 13 in 80% yield. The installation of the diol moiety with OsO4 was unsuccesful, due to the competitive oxidation of sulfur, preventing the completion of the synthesis.
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Al-Zereini, Wael. "Natural products from marine bacteria." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982197985.

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Books on the topic "Natural products"

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Zhang, Lixin, and Arnold L. Demain, eds. Natural Products. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1007/978-1-59259-976-9.

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Osbourn, Anne, Rebecca J. Goss, and Guy T. Carter, eds. Natural Products. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2014. http://dx.doi.org/10.1002/9781118794623.

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A, Beutler John, DerMarderosian Ara, and Facts and Comparisons (Firm), eds. Natural products. St. Louis, Mo: Facts and Comparisons, 2002.

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Nag, Moupriya, Dibyajit Lahiri, Jaideep Banerjee, and Taniya Roy Chowdhury. Natural Products. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003300557.

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P, Cannell Richard J., ed. Natural products isolation. Totowa, N.J: Humana Press, 1998.

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J, Cutler Stephen, and Cutler Horace G. 1932-, eds. Biologically active natural products: Pharmaceuticals. Boca Raton, FL: CRC Press, 2000.

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Sarker, Satyajit D., Zahid Latif, and Alexander I. Gray, eds. Natural Products Isolation. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1592599559.

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Kiyota, Hiromasa, ed. Marine Natural Products. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-4637-9.

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Kinghorn, A. Douglas, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, and Verena M. Dirsch, eds. Antimalarial Natural Products. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-89873-1.

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Sarker, Satyajit D., and Lutfun Nahar, eds. Natural Products Isolation. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-624-1.

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Book chapters on the topic "Natural products"

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Cooper, Rose. "Natural Products." In Russell, Hugo & Ayliffe's, 550–64. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118425831.ch22a.

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Kinghorn, A. Douglas, P. Annécie Benatrehina, and Garima Agarwal. "Natural Products." In Encyclopedia of Cancer, 1–4. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_3977-3.

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Spainhour, Charles B. "Natural Products." In Drug Discovery Handbook, 11–72. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2005. http://dx.doi.org/10.1002/0471728780.ch1.

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Buckingham, J. "Natural Products." In Chemical Nomenclature, 162–207. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4958-7_7.

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Petrzilka, Martin, and Charles Ehret. "Natural Products." In Perfumes, 499–531. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-3826-0_19.

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Kinghorn, A. Douglas, P. Annécie Benatrehina, and Garima Agarwal. "Natural Products." In Encyclopedia of Cancer, 3025–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-46875-3_3977.

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Chin, Young-Won, and A. Douglas Kinghorn. "Natural Products." In Encyclopedia of Cancer, 2465–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-16483-5_3977.

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Timbrell, John, and Frank A. Barile. "Natural Products." In Introduction to Toxicology, 189–200. 4th ed. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003188575-13.

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Zoeller, Jerome. "Natural Products." In Synthetic Sequences in Organic Chemistry, 53–90. Boca Raton: CRC Press, 2023. http://dx.doi.org/10.1201/9781003397816-3.

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Singh, Sheo B. "Pharmaceuticals: Natural Products and Natural Product Models." In Natural Products in Chemical Biology, 287–324. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118391815.ch12.

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Conference papers on the topic "Natural products"

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Luković, Milica, and Jovan Nićiforović. "NATURE AND NATURAL FOOD PRODUCTS IN FUTURE TOURIST’S PERSPECTIVE." In Tourism International Scientific Conference Vrnjačka Banja - TISC. FACULTY OF HOTEL MANAGEMENT AND TOURISM IN VRNJAČKA BANJA UNIVERSITY OF KRAGUJEVAC, 2022. http://dx.doi.org/10.52370/tisc22467ml.

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Two years after Covid-19 outbreak, the trend of local movements in ecologically clean areas is continuing. Parallel with searching for nature, tourists renew old, almost forgotten, traditional nature-inspired recipes. This study investigates tourists’ attitudes towards natural areas, interest in natural products experiences and their preference to renovate traditional healthy food products and to be included in future food tourism offers. The study includes standard and ethnobotanical interviews aimed to show the stronger connection between tourists and nature compared to the previous period and its intention to mitigate and adapt to Covid-19 challenges. The results show continuous changes in tourist perspective related to nature and natural food products in general. The results were compared with previous research and show that tourists are still interested in natural boosters through natural food, staying in nature, and active involvement in natural product collecting, however, the focus has shifted from traditional medicinal plants to edible ones.
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Pachlatko, J. "Natural Products in Crop Protection." In The 2nd International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 1998. http://dx.doi.org/10.3390/ecsoc-2-01701.

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Garten, Daniel, Katharina Anding, Steffen Lerm, Gerhard Linss, and Peter Brückner. "Image analysis of natural products." In OCM 2013 - Optical Characterization of Materials. KIT Scientific Publishing, 2013. http://dx.doi.org/10.58895/ksp/1000032143-15.

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Natural products are exposed to various environmental influences resulting in a high phenotypical variability. This makes it very difficult to develop automatic recognition algorithms in contrast to the recognition of manufactured products. Recent developments in the field of computer science, especially the development of powerful classification algorithms like the support vector machine make it possible to face also such complicated tasks. In this paper we present an approach to classify the impurities of a wheat sample to analyse the quality
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Nurmi, Petteri, Eemil Lagerspetz, Wray Buntine, Patrik Floréen, Joonas Kukkonen, and Peter Peltonen. "Natural language retrieval of grocery products." In Proceeding of the 17th ACM conference. New York, New York, USA: ACM Press, 2008. http://dx.doi.org/10.1145/1458082.1458308.

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Ozalp, Nesrin. "Energy, Environment, and Economical Advantages of Solar Thermal Cracking of Natural Gas." In ASME 2012 31st International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/omae2012-84222.

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Among all fossil fuels, natural gas is probably the most attractive one because of its higher heating value, and approximately 97% methane content, which creates less hazardous emissions during power generation. Considering these important facts and the demand for natural gas in the world market, it would be unlikely to think of converting natural gas. However, if we want to utilize our planet’s limited natural gas resources better, then we need to explore alternative ways. A way to achieve that goal is direct cracking of natural gas via solar thermal processing. This paper describes advantages of solar cracking of natural gas from energy, environment and economic point of view. Results show that products of natural gas decomposition contain 8% more energy per mole compared to natural gas itself, while the decomposition process does not emit any hazardous emissions to the environment. As for the economics, once the decomposition products of natural gas, namely hydrogen and carbon black, are sold separately, it is possible to make up to three times more revenue than the selling of natural gas. The products of natural gas decomposition have a very wide use in chemical and petroleum industries. For example, hydrogen is a crucial commodity to refine crude oil, while carbon black is the fundamental component in car tire, battery, conveyer belt, and printer ink manufacturing industries. Currently, petroleum industry produces hydrogen via steam reforming of methane and the chemical industry produces carbon black from coal or natural gas combustion in furnace, which are both highly toxic and global warming emissive processes. With solar cracking of natural gas, these two important commodities can be produced without any emissions to the environment.
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Schmidt, S., S. Bereswill, MM Heimesaat, and MF Melzig. "Natural products as modifiers of antibiotic resistance." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400064.

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"In Silico Drug Discovery using Natural Products." In INTERNATIONAL CONFERENCE ON BIOLOGICAL RESEARCH AND APPLIED SCIENCE. Jinnah University for Women, 2024. http://dx.doi.org/10.37962/ibras/2024/14.

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Grinberga, Juta, and Ilze Beitane. "A review: alternatives to substitute fructose in food products for patients with diabetes." In Research for Rural Development 2023 : annual 29th international scientific conference proceedings. Latvia University of Life Sciences and Technologies, 2023. http://dx.doi.org/10.22616/rrd.29.2023.008.

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Diabetes is a metabolic disease whose prevalence in the world is increasing every year. To improve the life quality of diabetes patients and achieve better treatment results, adjusted food products with lower carbohydrate quantities are necessary. Primarily fructose is used in products for diabetes patients, but fructose increases obesity risk. The aim of the study is to evaluate available scientific articles on potential natural sweeteners for the substitution of fructose in food products for people with diabetes. Natural sweeteners could be a good alternative to fructose, they decrease product glycemic index and positively influence the health of diabetes patients. Stevia is a plant used in food production for obtaining sweet taste. Glycosides extracted from stevia are food additives, i.e. sweeteners. Stevia decreases sugar levels and improves insulin secretion, it has antibacterial and antioxidative features. The use of stevia in food production causes a bitter aftertaste of products. To disguise the bitter aftertaste, other natural sweeteners are added to stevia. Thaumatin is a sweet protein used in food production. To improve product taste, polyols and other natural sweeteners are added. Polyols are a good alternative for fructose substitution because they slightly influence sugar levels in the blood and they have high chemical thermal stability. Products containing different combinations of several natural sweeteners possess the best sensory features. The research results show that stevioside, rebaudioside, thaumatin, and polyols are good alternatives for fructose substitution in products. To clarify how sweeteners, influence food product features additional researches are necessary.
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Hilton, Peter J., and Richard P. Gabric. "Multiple-image acquisition for inspection of natural products." In Photonics for Industrial Applications, edited by George E. Meyer and James A. DeShazer. SPIE, 1995. http://dx.doi.org/10.1117/12.198869.

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Cheng, Xian, Liangwu Bi, Zhendong Zhao, and Yuxiang Chen. "Advances in Enzyme Assisted Extraction of Natural Products." In 3rd International Conference on Material, Mechanical and Manufacturing Engineering (IC3ME 2015). Paris, France: Atlantis Press, 2015. http://dx.doi.org/10.2991/ic3me-15.2015.72.

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Reports on the topic "Natural products"

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Nguyen, Tuan Hoang. Synthesis of Polycyclic Natural Products. Office of Scientific and Technical Information (OSTI), January 2003. http://dx.doi.org/10.2172/815761.

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Lyle A. Johnson. Value-Added Products from Remote Natural Gas. Office of Scientific and Technical Information (OSTI), March 2002. http://dx.doi.org/10.2172/910125.

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Jeon, Insik. New Synthetic Methods for Hypericum Natural Products. Office of Scientific and Technical Information (OSTI), January 2006. http://dx.doi.org/10.2172/897366.

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Fallis, Kathleen, Katherine Harper, and Rich Ford. Control of Biofouling using Biodegradable Natural Products. Fort Belvoir, VA: Defense Technical Information Center, October 2002. http://dx.doi.org/10.21236/ada603755.

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DeMordaunt, Austin, Smriti Sharma, Merril Stypula, Corinne Charlton, and ShangMin Lin. Market Analysis: Upcycling Natural Gas Into Solid Carbon Products. Office of Scientific and Technical Information (OSTI), January 2022. http://dx.doi.org/10.2172/1838316.

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Kuchler, Fred, Megan Sweitzer, and Carolyn Chelius. prevalence of the "natural" claim on food product packaging. Washington, D.C.: USDA Economic Research Service, May 2023. http://dx.doi.org/10.32747/2023.8023700.ers.

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U.S. food suppliers make claims about their production processes on food packaging that highlight attributes some consumers want while charging a higher price than for unlabeled products. Some labels use such claims as "USDA Organic" and "raised without antibiotics," which require different and more expensive production techniques than conventional agriculture. However, food suppliers can use the label that claims the food is "natural" at a relatively low cost because regulatory agencies treat the claim as meaning nothing artificial was added and the product was minimally processed. Numerous consumer food choice studies concluded that consumers equate the natural label on food with healthier food choices and more costly production practices that signify environmental stewardship. Informed by these previous studies' findings, the authors of this report estimate the frequency with which food suppliers make the natural claim on food packaging labels. Estimates are based on scanner data and comprehensive label data. Across all foods in 2018, 16.3 percent of retail food expenditures and 16.9 percent of all items purchased (unit sales) were for foods labeled natural, whereas 11.0 percent of Universal Product Codes (UPC) in stores were labeled natural on the packaging. Expenditures for food labeled natural were larger than expenditures for foods labeled USDA Organic. Natural labels were found predominately on processed products. For example, 95.6 percent of expenditures for vitamins and meal supplements were for products labeled natural, compared with 0.5 percent of expenditures for potatoes
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Omelianenko, B. I., B. S. Niconov, B. I. Ryzhov, and N. D. Shikina. Weathering products of basic rocks as sorptive materials of natural radionuclides. Office of Scientific and Technical Information (OSTI), June 1994. http://dx.doi.org/10.2172/87335.

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Science, Fera. Analysis of CBD Products. Food Standards Agency, November 2022. http://dx.doi.org/10.46756/sci.fsa.cis490.

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The Food Standards Agency commissioned Fera Science Ltd. to carry out a survey to obtain a snapshot of CBD products on sale in England and Wales in order to inform FSA risk assessment of CBD products. Thirty CBD products were purchased from a range of online sellers from England and Wales. Samples comprised of two broad categories: oils and sprays, and edibles (including beverages). The sampling followed a scheme suggested by FSA. This is not a statistically representative sample of the market and instead provides a snapshot of the current market, to assist the design of future sampling and surveillance activity. There is the potential for residues of chemicals to be present in CBD products as a result of their natural occurrence in the raw material or arising from the manufacturing process, for example, mycotoxins, metals, pesticides, and the residues of solvents used to extract CBD. This study informs the FSA’s understanding of the type and levels of contaminants that may arise in CBD products. A wide range of analysis on CBD products was undertaken using accredited methods, for heavy metals, Polycyclic Aromatic Hydrocarbons (PAHs), pesticides, mycotoxins, CBD content and cannabinoid profiles. Analysis for residual solvents and additional mycotoxins was also carried out, but these were not accredited. The results of testing found the following: Heavy metals (cadmium, mercury & lead) and arsenic were not detected in the majority of samples, meaning levels were below the limits of quantification of the method. Seven samples contained lead, four samples arsenic and two samples contained cadmium. Mercury was not found in any sample. A definitive statement as to whether products exceed maximum levels cannot be made due to uncertainty as to whether products would be classified as a food (i.e. oil) or a food supplement. A low incidence of low levels of mycotoxins, with Fusarium mycotoxins found more frequently than aflatoxins and ochratoxin A, mostly at the methods reporting limit. Three samples were found to contain ochratoxin A at the methods reporting limit. A total of seven pesticide residues were found across all of the products (each product was tested for over 400 pesticides). There are no specific Maximum Residue Limits (MRL) for CBD products. One oil product was found to have PAHs above the regulated levels, if classed as a product for direct consumption. If classed as a food supplement the PAHs were within regulated levels. Three samples contained residual solvents. One product was over the MRL. Most products contained CBD close to the declared value. Two oils had substantially different levels than that declared (one higher and one lower). CBD was not detected in one of the drink products. These are potentially non-compliant with compositional and standards requirements. Delta 9-THC was detected in 87 % (26) of the samples analysed. Of these 40% (12) were found to have THC+ (the total sum of illicit cannabinoids in the product) above the 1mg threshold outlined in current Home Office guidance (Opens in a new window).
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Davis, Matthew C. New Ionic Liquids from Natural Products for Environmentally Benign Aircraft Deicing and Anti-Icing. Fort Belvoir, VA: Defense Technical Information Center, December 2010. http://dx.doi.org/10.21236/ada580819.

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10

Weaver, J., J. Wilson, D. Kampbell, and M. Randolph. Field-derived transformation rates for modeling natural bioattenuation of trichloroethene and its degradation products. Office of Scientific and Technical Information (OSTI), January 1996. http://dx.doi.org/10.2172/210807.

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