Academic literature on the topic 'Natural product synthesis'

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Journal articles on the topic "Natural product synthesis"

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Dai, Mingji, Xinpei Cai, and Yu Bai. "Total Syntheses of Spinosyn A." Synlett 29, no. 20 (September 7, 2018): 2623–32. http://dx.doi.org/10.1055/s-0037-1610249.

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Spinosyn A is an important polycyclic natural product with impressive insecticidal activity and has been used worldwide in agriculture as the major component of Spinosad. Herein, four chemical total syntheses of spinosyn A are summarized. Its biosynthesis and a chemoenzymatic total synthesis are discussed as well.1 Biosynthesis2 The Evans Synthesis3 The Paquette Synthesis4 The Roush Synthesis5 The Liu Synthesis6 The Dai Synthesis7 Conclusions
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Herzon, Seth B., and Christopher D. Vanderwal. "Introduction: Natural Product Synthesis." Chemical Reviews 117, no. 18 (September 27, 2017): 11649–50. http://dx.doi.org/10.1021/acs.chemrev.7b00520.

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Gladysz, J. A. "Introduction: Natural Product Synthesis." Chemical Reviews 105, no. 12 (December 2005): 4235–36. http://dx.doi.org/10.1021/cr0509713.

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Martin, Nelson, and Ruchi Bharti. "Arynes in Natural Product Synthesis." International Journal for Research in Applied Science and Engineering Technology 11, no. 4 (April 30, 2023): 2633–44. http://dx.doi.org/10.22214/ijraset.2023.50703.

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Abstract: Arynes are a unique class of intermediates used in synthetic organic chemistry, and research interest has been intensely focused on their peculiar reactivities. Arynes have been researched for almost a century. However, difficulties in monitoring these reactive species, as well as difficulties in creating synthetically viable techniques for their synthesis and trapping, have restricted their application. A key tactic for achieving the racemic and enantiopure total synthesis of a broad variety of natural compounds or their structural derivatives. The chemistry of arynes has advanced significantly over the past thirty years, particularly in the field of transition metal carbon- carbon and carbon-heteroatom bond-forming mechanisms. The field’s fast growth is largely attributable to the development of mild aryne production processes. To create a natural product with complex organic molecules, the role of aryne intermediates was non-replaceable. These organic substances are often used in medicine, therapies, or as raw material for the synthesis of other substances. Moreover, they may perform important biological tasks. There are numerous methods for synthesizing natural compounds including total synthesis, semi-synthesis, and biosynthesis. Total synthesis is the process of creating natural products entirely chemically from basic precursors as well as it can be produced in large quantities and can reveal information about its biological activity. One of the developments in Arynes’ chemistry is the chemical rearrangements brought about by this electrophilic intermediate. It is not feasible to use conventional methods in a single step. This review article discusses how arynes are used to create natural products. Arynes has a wide range of functionality in the field of scientific research. The evolution of this method has made a tremendous change in the total synthesis of natural products. Benzynes enabled creative synthesis in mild conditions. The transformation has expanded to investigate various reaction classes such as nucleophilic addition, (4+2), and (2+2) cycloaddition strategies and metal-catalyzed reactions are shown and explained in this article. This review will provide an idea about how the arynes act as an intermediate in those reaction mechanisms and enlighten the scope of these aryne intermediate.
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Vanable, Evan P., Laurel G. Habgood, and James D. Patrone. "Current Progress in the Chemoenzymatic Synthesis of Natural Products." Molecules 27, no. 19 (September 27, 2022): 6373. http://dx.doi.org/10.3390/molecules27196373.

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Natural products, with their array of structural complexity, diversity, and biological activity, have inspired generations of chemists and driven the advancement of techniques in their total syntheses. The field of natural product synthesis continuously evolves through the development of methodologies to improve stereoselectivity, yield, scalability, substrate scope, late-stage functionalization, and/or enable novel reactions. One of the more interesting and unique techniques to emerge in the last thirty years is the use of chemoenzymatic reactions in the synthesis of natural products. This review highlights some of the recent examples and progress in the chemoenzymatic synthesis of natural products from 2019–2022.
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Hou, Si-Hua, Feng-Fan Zhou, Yi-Hang Sun, and Quan-Zhe Li. "Deconstructive and Divergent Synthesis of Bioactive Natural Products." Molecules 28, no. 17 (August 22, 2023): 6193. http://dx.doi.org/10.3390/molecules28176193.

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Natural products play a key role in innovative drug discovery. To explore the potential application of natural products and their analogues in pharmacology, total synthesis is a key tool that provides natural product candidates and synthetic analogues for drug development and potential clinical trials. Deconstructive synthesis, namely building new, challenging structures through bond cleavage of easily accessible moieties, has emerged as a useful design principle in synthesizing bioactive natural products. Divergent synthesis, namely synthesizing many natural products from a common intermediate, can improve the efficiency of chemical synthesis and generate libraries of molecules with unprecedented structural diversity. In this review, we will firstly introduce five recent and excellent examples of deconstructive and divergent syntheses of natural products (2021–2023). Then, we will summarize our previous work on the deconstructive and divergent synthesis of natural products to demonstrate the high efficiency and simplicity of these two strategies in the field of total synthesis.
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Romero, Kevin J., Matthew S. Galliher, Derek A. Pratt, and Corey R. J. Stephenson. "Radicals in natural product synthesis." Chemical Society Reviews 47, no. 21 (2018): 7851–66. http://dx.doi.org/10.1039/c8cs00379c.

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Free radical intermediates have intrigued chemists since their discovery, and an ever-increasing appreciation for their unique reactivity has resulted in the widespread utilization of these species for natural product synthesis.
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Hatakeyama, Susumi. "Fascinated by Natural Product Synthesis." Journal of Synthetic Organic Chemistry, Japan 78, no. 10 (October 1, 2020): 986–89. http://dx.doi.org/10.5059/yukigoseikyokaishi.78.986.

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Hetzler, Belinda E., Dirk Trauner, and Andrew L. Lawrence. "Natural product anticipation through synthesis." Nature Reviews Chemistry 6, no. 3 (January 14, 2022): 170–81. http://dx.doi.org/10.1038/s41570-021-00345-7.

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Dragutan, Reviewed by Valerian, and Ileana Dragutan. "“Metathesis in Natural Product Synthesis”." Platinum Metals Review 55, no. 1 (January 1, 2011): 33–49. http://dx.doi.org/10.1595/147106711x543190.

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Dissertations / Theses on the topic "Natural product synthesis"

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Liu, Yunqi. "Synthetic approaches toward natural product synthesis." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187050.

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1,2-Dithiolan-3-one-1-oxide exists in antihumor antibiotic leinamycin and can cause DNA cleavage in the presence of thiols. Diastereoselective synthesis of this unique ring system has been achieved by low temperature oxidation of the corresponding 1,2-dithiolan-3-ones with 3,3-dimethyldioxirane. 5-Methyl-1,2-dithiolan-3-one-1-oxides were synthesized by oxidation of 5-methyl-1,2-dithiolan-3-one with 3,3-dimethyldioxirane. Eu(fod)₃ and C₆D₆ induced proton chemical shift studies showed that the major isomer in the product has a trans sulfoxide relative to the 5-methyl group. Low temperature oxidation of 4-substituted-amino-5,5-dimethyl-1,2-dithiolan-3-ones by 3,3-dimethyldioxirane preferentially led to the corresponding trans-1,2-dithiolan-3-one-1-oxides. This assignment was made on the basis of a X-ray crystallographic structure study. Formation of azlactones as well as 1,2-dithiolan-3-one-1,1-dioxide were also observed when some substituted 1,2-dithiolan-3-ones were oxidized by 3,3-ditnethyldioxirane. Three 2,2-dimethyl-1,3-dithian-4-ones were synthesized by SnCl₄ mediated condensation of β-mercaptothioacids and acetone. Oxidation of 2,2,6-trimethyl-1,3-dithian-4-one with Ce(IV) did not give 1,2-dithiolan-3-one or 1,2-dithiolan-3-one-1-oxides as anticipated; 1,3-dithian-5-en-4-one was detected as the product instead. Synthetic approaches toward loline were explored. Intramolecular photoaddition of bicyclic olefinic N-nitrosamine did not give the desired product. An epoxide approach did not furnish loline due to unsuccessful epoxide ring opening by azide ion. In the urea approach, the tertiary nitrogen of the bicyclic urea preferentially undergoes a transannular iodocyclization. The same results were obtained by halocyclizing bis-silylimidate or mono-silylimidate of the bicyclic urea.
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Li, I. C. K. "Natural product syntheses." Thesis, University of Southampton, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375675.

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Vollmer, Heidi R. "Biologically active natural product synthesis." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365780.

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Merifield, Eric. "Aspects of natural product synthesis." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.258148.

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Longbottom, Deborah Anne. "Polyenoyltetramic acid natural product synthesis." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620206.

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Hunter, Ruth F. "Benzynes in natural product synthesis." Thesis, University of Manchester, 1989. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.655226.

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Foot, Jonathan Stuart. "New synthetic methodology and antiviral natural product synthesis." Thesis, University of York, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412621.

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Thite, Aniket Mohan. "Direct approaches toward natural product synthesis." [Ames, Iowa : Iowa State University], 2007.

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Sperry, Jonathan. "Biomimetic oxidations in natural product synthesis." Thesis, University of Exeter, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425500.

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Hinks, Jeremy David. "Metal carbenes in natural product synthesis." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393940.

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Books on the topic "Natural product synthesis"

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1944-, Mulzer J., ed. Natural product synthesis. Berlin: Springer-Verlag, 2005.

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Mulzer, J. Natural Product Synthesis I. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/b93169.

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Majumdar, Krishna C., and Shital K. Chattopadhyay, eds. Heterocycles in Natural Product Synthesis. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634880.

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Huang, Pei-Qiang, Zhu-Jun Yao, and Richard P. Hsung, eds. Efficiency in Natural Product Total Synthesis. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2018. http://dx.doi.org/10.1002/9781118940228.

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Kinghorn, A. Douglas, Heinz Falk, Simon Gibbons, Yoshinori Asakawa, Ji-Kai Liu, and Verena M. Dirsch, eds. Modern Photocatalytic Strategies in Natural Product Synthesis. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-11783-1.

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Metathesis in natural product synthesis: Strategies, substrates and catalysts. Weinheim: Wiley-VCH, 2010.

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H, Pearson William, ed. Advances in heterocyclic natural product synthesis: A research annual. Greenwich, Co: Jai Press, 1992.

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Ricketts, Dean Christopher. Applications of chromium carbene annulations and cyclisations to natural product synthesis. Manchester: University of Manchester, 1993.

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Jeffrey, Stephen. The use of Thian-4-one derivatives in cyclopentenone natural product synthesis. Norwich: University ofEast Anglia, 1990.

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service), ScienceDirect (Online, ed. Complex enzymes in microbial natural product biosynthesis: Overview articles and peptides. Amsterdam: Elsevier, 2009.

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Book chapters on the topic "Natural product synthesis"

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Okuda, Yasuhiro, and Yasushi Nishihara. "Natural Product Synthesis." In Lecture Notes in Chemistry, 43–83. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-32368-3_3.

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Tohma, Hirofumi, and Yasuyuki Kita. "Synthetic Applications (Total Synthesis and Natural Product Synthesis)." In Hypervalent Iodine Chemistry, 209–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/3-540-46114-0_8.

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Parker, Kathlyn A. "Cyclization Approaches to the Synthesis of Natural Products." In Natural Product Chemistry, 307–17. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71425-2_16.

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Schmidt, Richard R. "Natural Product Synthesis Via Functionally Substituted Vinyl Carbanions." In Natural Product Chemistry, 383–403. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71425-2_20.

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Mohd Nor, Siti Mariam, Zhengshuang Xu, and Tao Ye. "Bioactive Macrocyclic Natural Products." In Heterocycles in Natural Product Synthesis, 569–619. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634880.ch16.

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Botuha, Candice, Fabrice Chemla, Franck Ferreira, and Alejandro Pérez-Luna. "Aziridines in Natural Product Synthesis." In Heterocycles in Natural Product Synthesis, 1–39. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634880.ch1.

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Voelter, Wolfgang. "Hypothalamic Hormones, Aspects of Structure, Synthesis and Biological Activity." In Natural Product Chemistry, 485–507. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71425-2_25.

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Bates, Roderick W., and Sivarajan Kasinathan. "Hydroformylation in Natural Product Synthesis." In Topics in Current Chemistry, 187–223. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/128_2013_428.

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Marco-Contelles, José, and Elena Soriano. "Rearrangements in Natural Product Synthesis." In Modern Tools for the Synthesis of Complex Bioactive Molecules, 243–69. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118342886.ch8.

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Appukkuttan, Prasad, and Erik Van der Eycken. "Microwave-Assisted Natural Product Chemistry." In Microwave Methods in Organic Synthesis, 1–47. Berlin, Heidelberg: Springer Berlin Heidelberg, 2006. http://dx.doi.org/10.1007/128_051.

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Conference papers on the topic "Natural product synthesis"

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Serra, Gloria, Stella Peña, Laura Scarone, and Eduardo Manta. "Synthesis of a Macrocyclic Marine Natural Product Analog." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0079-1.

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Lazaro, Aline Simões, Paulo Marcos Donate, and Mirela Inês de Sairre. "A new approach to the synthesis of natural product Aripuanin." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0301-2.

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Blaja, Svetlana, Kaleria Kuchkova, Lidia Lungu, Vasile Lozovan, and Aculina Aricu. "Synthesis of hydrazide containing trinorlabdane derivatives." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab15.

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Qin, Feiwei, Hairui Xu, Weicheng Zhang, Lin Yuan, Ming Li, Yusheng Liu, Ying Liu, and Yong Chen. "Voice of the Customer Oriented New Product Synthesis Over Knowledge Graphs." In ASME 2018 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/detc2018-85909.

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The online shopping has been much easier and popular, and meanwhile brings new challenges and opportunities to the field of product design and marketing sale. On one hand, product manufacturers find it challenging to produce new popularly accepted products to meet the customers’ needs; on the other hand, end customers usually feel it difficult to buy ideal goods that they really want, even if navigating a huge amount of commodities. There are indeed a ‘communication gap’ between the customers and manufacturers. As an effort to partially resolve the issue, this paper proposes a novel product synthesis approach from ‘voice of the customer’ over product knowledge graphs. Here the voice of customers mainly refer to the buyers’ product reviews from online shopping platforms or blogs, while the product knowledge graph is constructed containing professional hierarchical product knowledge on its properties based on ontological models. Using the technologies of natural language processing, we first extract the customs’ polarities on each specific aspect of a product, which are then transited to design requirements on the product’s design components. Based on the requirement extractions, and the pre-built product knowledge, semantic web and reasoning techniques are utilized to synthesize a novel product that meets more customer needs. Typical case studies on mobile phones from raw online data demonstrate the proposed approach’s performance.
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Morarescu, Olga, Marionela Traistari, Alic Barba, Gheorghe Duca, Nicon Ungur, and Veaceslav Kulcitki. "Selective synthesis of 13-epi-manoyl oxide." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab27.

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Amarandi, Roxana-Maria, Maria-Cristina Al-Matarneh, Lacramioara Popovici, Ionel Mangalagiu, Vasilichia Bejan, Catalina-Ionica Ciobanu, and Ramona Danac. "Pyrrolo-fused heterocyclic derivatives: design, synthesis and anticancer evaluation." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab17.

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Aricu, Aculina, Kaleria Kuchkova, Svetlana Blaja, and Alic Barba. "Synthesis of some homodrimane sesquiterpenoids with dihydrazide fragment from norambreinolide." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab25.

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Blaja, Svetlana, Aculina Aricu, Kaleria Kuchkova, and Alic Barba. "Synthesis of some new homodrimane derivatives of benzothiazole from norambreinolide." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab26.

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Ungur, Nicon, and Veaceslav Kulcitki. "Mollecular rearrangements in the synthesis of bioactive terpenoids with new carbon skeletons." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab11.

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Sucman, Natalia, Timur Andrusenco, and Fliur Macaev. "Synthesis of hybrid molecules by interaction of 2-hydroxy juglone with terpenoid aldehydes." In New frontiers in natural product chemistry, scientific seminar with international participation. Institute of Chemistry, 2021. http://dx.doi.org/10.19261/nfnpc.2021.ab29.

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Reports on the topic "Natural product synthesis"

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Nguyen, Tuan Hoang. Synthesis of Polycyclic Natural Products. Office of Scientific and Technical Information (OSTI), January 2003. http://dx.doi.org/10.2172/815761.

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Jeon, Insik. New Synthetic Methods for Hypericum Natural Products. Office of Scientific and Technical Information (OSTI), January 2006. http://dx.doi.org/10.2172/897366.

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Mark Scotto. Evaluation of Reformer Produced Synthesis Gas for Emissions Reductions in Natural Gas Reciprocating Engines. Office of Scientific and Technical Information (OSTI), May 2010. http://dx.doi.org/10.2172/1015866.

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Mark V. Scotto and Mark A. Perna. Evaluation of Reformer Produced Synthesis Gas for Emissions Reductions in Natural Gas Reciprocating Engines. Office of Scientific and Technical Information (OSTI), May 2010. http://dx.doi.org/10.2172/1030637.

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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, October 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and pupariation activities; (ii) Test the inhibitory potencies of the BBC compounds on the above activities evoked either by synthetic peptides (PBAN, LPK, myotropin and pheromonotropin) or by the natural endogenous mechanism; (iii) Determine the bioavailability of the most potent BBC compounds that will be found in (ii); (iv) Design, synthesize and examine novel PK/PBAN analogs with enhanced bioavailability and receptor binding; (v) Design and synthesize ‘magic bullet’ analogs and examine their ability to selectively kill cells expressing the PK/PBAN receptor. To achieve these goals the agonistic and antagonistic activities/properties of rationally designed linear and BBC neuropeptide (NP) were thoroughly studied and the information obtained was further used for the design and synthesis of improved compounds toward the design of an insecticide prototype. The study revealed important information on the structure activity relationship (SAR) of agonistic/antagonistic peptides, including definitive identification of the orientation of the Pro residue as trans for agonist activity in 4 PK/PBANbioassays (pheromonotropic, pupariation, melanotropic, & hindgut contractile) and a PK-related CAP₂b bioassay (diuretic); indications that led to the identification of a novel scaffold to develop biostbiostable, bioavailable peptidomimetic PK/PBANagonists/antagonists. The work led to the development of an arsenal of PK/PBAN antagonists with a variety of selectivity profiles; whether between different PKbioassays, or within the same bioassay between different natural elicitors. Examples include selective and non-selective BBC and novel amphiphilic PK pheromonotropic and melanotropic antagonists some of which are capable of penetrating the moth cuticle in efficacious quantities. One of the latter analog group demonstrated unprecedented versatility in its ability to antagonize a broad spectrum of pheromonotropic elicitors. A novel, transPro mimetic motif was proposed & used to develop a strong, selective PK agonist of the melanotropic bioassay in moths. The first antagonist (pure) of PK-related CAP₂b diuresis in flies was developed using a cisPro mimetic motif; an indication that while a transPro orientation is associated with receptor agonism, a cisPro orientation is linked with an antagonist interaction. A novel, biostablePK analog, incorporating β-amino acids at key peptidase-susceptible sites, exhibited in vivo pheromonotropic activity that by far exceeded that of PBAN when applied topically. Direct analysis of neural tissue by state-of-the-art MALDI-TOF/TOF mass spectrometry was used to identify specific PK/PK-related peptides native to eight arthropod pest species [house (M. domestica), stable (S. calcitrans), horn (H. irritans) & flesh (N. bullata) flies; Southern cattle fever tick (B. microplus), European tick (I. ricinus), yellow fever mosquito (A. aegypti), & Southern Green Stink Bug (N. viridula)]; including the unprecedented identification of mass-identical Leu/Ile residues and the first identification of NPs from a tick or the CNS of Hemiptera. Evidence was obtained for the selection of Neb-PK-2 as the primary pupariation factor of the flesh fly (N. bullata) among native PK/PK-related candidates. The peptidomic techniques were also used to map the location of PK/PK-related NP in the nervous system of the model fly D. melanogaster. Knowledge of specific PK sequences can aid in the future design of species specific (or non-specific) NP agonists/antagonists. In addition, the study led to the first cloning of a PK/PBAN receptor from insect larvae (S. littoralis), providing the basis for SAR analysis for the future design of 2ⁿᵈgeneration selective and/or nonselective agonists/antagonists. Development of a microplate ligand binding assay using the PK/PBAN pheromone gland receptor was also carried out. The assay will enable screening, including high throughput, of various libraries (chemical, molecular & natural product) for the discovery of receptor specific agonists/antagonists. In summary, the body of work achieves several key milestones and brings us significantly closer to the development of novel, environmentally friendly pest insect management agents based on insect PK/PBANNPs capable of disrupting critical NP-regulated functions.
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Shkurupiy, Valeria, and Nikita Budnyi. A priori estimation of instrumental error of energy characteristics of an electric rocket engine. Baltic State Technical University “VOENMEH” named after D.F.Ustinov, 2023. http://dx.doi.org/10.12731/edn:dkwobv.

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In this work, the power of the calculated electric rocket engine (ERE) requires thrust, specific impulse, and efficiency. ERE thrust measurement is interesting enough to achieve smallness of rapid growth. Specific impulse and efficiency are measured using laboratory methods. For this reason, one should naturally approach the choice of design parameters and the composition of the measuring system. One of the synthesis products can be the minimization of measurement errors. The paper approaches an approach to a priori instrumental estimation of the error determination, which may be useful in the synthesis of a system measurement of the ERE characteristics.
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Dudley, J. P., and S. V. Samsonov. Système de traitement automatisé du gouvernement canadien pour la détection des variations et l'analyse des déformations du sol à partir des données de radar à synthèse d'ouverture de RADARSAT-2 et de la mission de la Constellation RADARSAT : description et guide de l'utilisateur. Natural Resources Canada/CMSS/Information Management, 2021. http://dx.doi.org/10.4095/329134.

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Remote sensing using Synthetic Aperture Radar (SAR) offers powerful methods for monitoring ground deformation from both natural and anthropogenic sources. Advanced analysis techniques such as Differential Interferometric Synthetic Aperture Radar (DInSAR), change detection, and Speckle Offset Tracking (SPO) provide sensitive measures of ground movement. With both the RADARSAT-2 and RADARSAT Constellation Mission (RCM) SAR satellites, Canada has access to a significant catalogue of SAR data. To make use of this data, the Canada Centre for Mapping and Earth Observation (CCMEO) has developed an automated system for generating standard and advanced deformation products from SAR data using both DInSAR and SPO methods. This document provides a user guide for this automated processing system.
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KellerLynn, Katie. Organ Pipe Cactus National Monument: Geologic resources inventory report. National Park Service, June 2022. http://dx.doi.org/10.36967/2293664.

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Geologic Resources Inventory reports provide information and resources to help park managers make decisions for visitor safety, planning and protection of infrastructure, and preservation of natural and cultural resources. Information in GRI reports may also be useful for interpretation. This report synthesizes discussions from a scoping meeting held in 2006 and a follow-up conference call in 2020. Chapters of this report discuss the geologic heritage, geologic history, geologic features and processes, and geologic resource management issues of Organ Pipe Cactus National Monument. Guidance for resource management and information about the previously completed GRI GIS data is also provided. A GRI poster (separate product) illustrates the GRI map data.
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Barthelmes, Michael. Tallgrass Prairie National Preserve: Geologic resources inventory report. National Park Service, October 2022. http://dx.doi.org/10.36967/2294502.

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Geologic Resources Inventory reports provide information and resources to help park managers make decisions for visitor safety, planning and protection of infrastructure, and preservation of natural and cultural resources. Information in GRI reports may also be useful for interpretation. This report synthesizes discussions from a scoping meeting held in 2008 and a follow-up conference call in 2021. Chapters of this report discuss the geologic heritage, geologic history, geologic features and processes, and geologic resource management issues of Tallgrass Prairie National Preserve. Guidance for resource management and information about the previously completed GRI GIS data and poster (separate products) is also provided.
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Thornberry-Ehrlich, Trista. Little River Canyon National Preserve: Geologic resources inventory report. National Park Service, October 2022. http://dx.doi.org/10.36967/2294826.

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Geologic Resources Inventory reports provide information and resources to help park managers make decisions for visitor safety, planning and protection of infrastructure, and preservation of natural and cultural resources. Information in GRI reports may also be useful for interpretation. This report synthesizes discussions from a scoping meeting held in 2009 and a follow-up conference call in 2020. Chapters of this report discuss the geologic heritage, geologic features and processes, and geologic resource management issues of Little River Canyon National Preserve. Guidance for resource management and information about the previously completed GRI GIS data and poster (separate products) is also provided.
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