Journal articles on the topic 'NAT device'
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Sun, Wei, Hao Zhang, Li-jun Cai, Ai-min Yu, Jin-qiao Shi, and Jian-guo Jiang. "A Novel Device Identification Method Based on Passive Measurement." Security and Communication Networks 2019 (June 23, 2019): 1–11. http://dx.doi.org/10.1155/2019/6045251.
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Nowadays, with the continuous integration of production network and business network, more and more Industrial Internet of Things and Internal Office Network have been interconnected and evolved into a large-scale enterprise-level intraindustry network. Terminal devices are the basic units of internal network. Accurate identification of the type of device corresponding to the IP address and detailed description of the communication behavior of the device are of great significance for conducting network security risk assessment, hidden danger investigation, and threat warning. Traditional cyberspace surveying and mapping techniques take the form of active measurement, but they cannot be transplanted to large-scale intranet. Resources or specific targets in internal networks are often protected by firewalls, VPNs, gateways, and other technologies, so they are difficult to analyze and determine by active measurement. In this paper, a passive measurement method is proposed to identify and characterize devices in the network through real traffic data. Firstly, a new graph structure mining method is used to determine the server-like devices and host-like devices; then, the NAT-like devices are determined by quantitative analysis of traffic; finally, by qualitative analysis of the NAT-like device traffic, it is determined whether there are server-like devices behind the NAT-like device. This method will prove to be useful in identifying all kinds of devices in network data traffic, detecting unauthorized NAT-like devices and whether there are server-like devices behind the NAT-like devices.
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Zhu, Hejun, and Liehuang Zhu. "Traffic Identification Based on User Access Authentication and Message Tag." Journal of Computational and Theoretical Nanoscience 14, no. 1 (January 1, 2017): 1–6. http://dx.doi.org/10.1166/jctn.2017.6114.
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In order to solve the problem of direct location management of Internet users under the environment of NAT, the unique session ID that represents the user session was put the first option location of the initial session SYN option, and the same session ID was put the additional tail part of the each initial UDP session and the specified UDP tail part, the traffic identification and location management of the Internet users were realized under the environment of NAT through the message tag and user access authentication, the practical application showed that compared with the traditional method, this method not only solved the location management of the Internet users under the NAT, but also greatly reduced the Internet authentication device, network mirror device, network transmission device, network bandwidth and other resources.
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Lee, Seungwoon, Si Jung Kim, Jungtae Lee, and Byeong-hee Roh. "Supervised Learning-Based Fast, Stealthy, and Active NAT Device Identification Using Port Response Patterns." Symmetry 12, no. 9 (September 2, 2020): 1444. http://dx.doi.org/10.3390/sym12091444.
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Although network address translation (NAT) provides various advantages, it may cause potential threats to network operations. For network administrators to operate networks effectively and securely, it may be necessary to verify whether an assigned IP address is using NAT or not. In this paper, we propose a supervised learning-based active NAT device (NATD) identification using port response patterns. The proposed model utilizes the asymmetric port response patterns between NATD and non-NATD. In addition, to reduce the time and to solve the security issue that supervised learning approaches exhibit, we propose a fast and stealthy NATD identification method. The proposed method can perform the identification remotely, unlike conventional methods that should operate in the same network as the targets. The experimental results demonstrate that the proposed method is effective, exhibiting a F1 score of over 90%. With the efficient features of the proposed methods, we recommend some practical use cases that can contribute to managing networks securely and effectively.
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Liu, Wenhan, Jagotamoy Das, Adam H. Mepham, Carine R. Nemr, Edward H. Sargent, and Shana O. Kelley. "A fully-integrated and automated testing device for PCR-free viral nucleic acid detection in whole blood." Lab on a Chip 18, no. 13 (2018): 1928–35. http://dx.doi.org/10.1039/c8lc00371h.
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Shin, HaeJoon, and YounKy Chung. "Device Alive Check Algorithm using TCP Session under CCTV Network based on NAT." Journal of Korea Multimedia Society 18, no. 5 (May 30, 2015): 631–40. http://dx.doi.org/10.9717/kmms.2015.18.5.631.
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Zhou, Wenjie, Zizhuo Liu, Ziyin Huang, Haixin Lin, Devleena Samanta, Qing-Yuan Lin, Koray Aydin, and Chad A. Mirkin. "Device-quality, reconfigurable metamaterials from shape-directed nanocrystal assembly." Proceedings of the National Academy of Sciences 117, no. 35 (August 17, 2020): 21052–57. http://dx.doi.org/10.1073/pnas.2006797117.
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Anchoring nanoscale building blocks, regardless of their shape, into specific arrangements on surfaces presents a significant challenge for the fabrication of next-generation chip-based nanophotonic devices. Current methods to prepare nanocrystal arrays lack the precision, generalizability, and postsynthetic robustness required for the fabrication of device-quality, nanocrystal-based metamaterials [Q. Y. Lin et al. Nano Lett. 15, 4699–4703 (2015); V. Flauraud et al., Nat. Nanotechnol. 12, 73–80 (2017)]. To address this challenge, we have developed a synthetic strategy to precisely arrange any anisotropic colloidal nanoparticle onto a substrate using a shallow-template-assisted, DNA-mediated assembly approach. We show that anisotropic nanoparticles of virtually any shape can be anchored onto surfaces in any desired arrangement, with precise positional and orientational control. Importantly, the technique allows nanoparticles to be patterned over a large surface area, with interparticle distances as small as 4 nm, providing the opportunity to exploit light–matter interactions in an unprecedented manner. As a proof-of-concept, we have synthesized a nanocrystal-based, dynamically tunable metasurface (an anomalous reflector), demonstrating the potential of this nanoparticle-based metamaterial synthesis platform.
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Asseldonk, Tedje Van, Pericles Bourkas, Alexandra Delinick, Galen Ives, Costas Karragiannopoulos, Rainer Lüdtke, Michel van Wassenhoven, Claudia Witt, and Harald Walach. "Electric measurement of ultra-high dilutions—a blinded controlled experiment." British Homeopathic Journal 87, no. 01 (January 1998): 3–12. http://dx.doi.org/10.1016/s0007-0785(98)80003-3.
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AbstractThis experiment was designed to test the hypothesis put forward by P. Bourkas, A. Delinick and C. Karragiannopoulos of the National Technical University of Athens (NTUA) that Ultra High Succussed Dilutions (UHSD) can be distinguished from control solutions by an Electric Measurement Device (EMD), developed by the NTUA team. A pre-formulated experimental protocol was followed, measuring in random sequence test solutions of double-distilled and deionised water (aqua injectabile), potentised water (6 cH, 30 cH), Natrum muriaticum (Nat mur) potentised in aqua injectabile (6 cH, 30 cH), either blind or open. The number of measurements was determined by a power analysis based on open pilot readings. While the open pilot trial performed by the NTUA team showed a large difference in readings for the controls and test-solutions, the experimental blind test was negative. The only significant difference observed was between Nat mur 6 cH and Nat mur 30 cH, and the direction of the difference was in the opposite direction from that predicted by theory and found in the pilot experiment. No differences were found between any other conditions, and in particular Nat mur 30 cH and aqua 30 cH could not be distinguished. It was suggested that the failure to detect a difference in the main trial resulted from a different brand of water being used in the main trial; the likelihood of this, and other alternative explanations, is discussed. It was concluded that the EMD is a highly sensitive apparatus for measuring impurities in water. As yet there is no obvious link between the measurement of impurities in water and the purported alteration of solvent in the process of homoeopathic potentisation.
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Xiao, Yu Zhi. "On the Research of Internet Equipment Naming Methods." Advanced Materials Research 664 (February 2013): 1021–27. http://dx.doi.org/10.4028/www.scientific.net/amr.664.1021.
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This paper analyzes the content of Internet naming problems as well as the current exist problems .We discuss the namespace and the major technologies, and then elaborating the important thinking on research of naming problems detailed and propose development direction in the future. In the paper, we propose a new method for devices naming due to the issues that exist in the Internet naming. Using this technical, it can solve the problem of the extremely scarce IPv4 and the IP address changed frequently on Internet devices. Equipment naming scheme has five major components: equipment name registered server, equipment communication server and client domain name server and client communication agency, the client login and configuration. It is a pattern in which the mobile device uses configured client software to issue a request to NG-DNS (new generation domain system).we have analyze on the realization of the key technology on the windows system. It has realized communication among equipments which are mobile, wireless, dynamic IP address, and hidden NAT and firewall. The method can be extended entry of Android devices.
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Tung, Shu Chu, Wu Jeng Li, Kuang Chyi Lee, and Jui Chang Lin. "Environment Supervisory Control of Computer Room Based on Android Device." Applied Mechanics and Materials 418 (September 2013): 124–27. http://dx.doi.org/10.4028/www.scientific.net/amm.418.124.
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This research designs environment supervisory control system of computer room which consists of multiple Android environment controllers and one supervisory control server. An Android environment controller is a controller based on Android device. The controller contains an Android device, a Wi-Fi wireless access point, a switch hut (or NAT) and three data acquisition modules. The Android device enters TCP/IP LAN through the Wi-Fi access point. The data acquisition modules with TCP/IP interface are plugged into the LAN, and read/written by the Android device with Modbus TCP/IP protocol. Control logics are designed for computer room environment control. The controller monitors air conditioning systems, room temperature and humidity, fire alarm systems, uninterruptible power supply (UPS) systems, electricity supply systems, leak detections, and door access control systems. If something happens, it can drive buzzer, alarm, voice dialing, or air conditioning, send SMS, voice mail, record audio, or video. A supervisory control server is used to help remote controls of all Android environment controllers. All Android controllers send their operation data to the server. Authorized user can login to the server to monitor and control certain Android controller with a browser or Android device.
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Ţepelea, L., I. Gavriluţ, O. Neamţu, E. Gergely, and A. Gacsádi. "A LabVIEW-Based Soundcard Interface for E-Laboratory." International Review of Applied Sciences and Engineering 2, no. 2 (December 1, 2011): 137–42. http://dx.doi.org/10.1556/irase.2.2011.2.10.
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Abstract The purpose of this paper is to present a way to develop a technical e-laboratory for students interested in their continuing training. It presents hardware and software aspects regarding design of a LabVIEW-Based Soundcard Interface for E-Laboratory. To realize an e-learning laboratory we used web publishing tool from LabVIEW and the connection between server and remote computer is realized with a VPN software to pass through any router or a NAT device and realise a secure tunnel between remote computers and LabVIEW web-server. Also, the web publishing tool from LabVIEW allows concurrent access from different remote computers to e-laboratory. For example paper offers a LabVIEW application for acquisition and generation of signals using the sound card.
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Barkhoudarian, Garni, Nicholas Blondin, Sajeel Chowdhary, Ekokobe Fonkem, Brian Vaillant, and Santosh Kesari. "ACTR-69. FEASIBILITY STUDY OF THE EMULATE THERAPEUTICS™ VOYAGER SYSTEM IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (November 2019): vi29. http://dx.doi.org/10.1093/neuonc/noz175.110.
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Abstract BACKGROUND The EMulate Therapeutics Voyager system is an investigational non-sterile, non-invasive, non-thermal, non-ionizing, portable, home-use medical device that uses a specific, localized ultra-low radio frequency energy (ulRFE®) cognate for the treatment of brain cancer. METHODS This open-label, multi-center study (NAT-109) enrolled adults newly diagnosed with GBM. Following surgical debulking, patients were enrolled and treated concurrently with temozolomide, radiotherapy, and Voyager. The objective of the study is to assess if the Voyager is a safe and feasible treatment for newly diagnosed GBM when combined with standard of care. The primary outcome measure is safety, assessed by the incidence and evaluation of any adverse events (AEs) associated with the Voyager. The secondary outcome measure is clinical utility, assessed by progression-free survival and overall survival. RESULTS Enrollment is closed, and treatment and long-term follow-up is ongoing. A total of 37 patients were enrolled and treated. 27 patients reported 282 AEs, none of which required withdrawal from the study. One AE was reported as probably related to the device - i.e., mild dysesthesia, which resolved without interruption or cessation of treatment with the device. 15 patients reported 28 SAEs, and none were reported as related to the device. 56% of patients were progression-free at 6 months, and 43% were progression-free at 12 months. 89% of patients were still alive after 6 months, 71% were still alive after 12 months. CONCLUSIONS The Voyager system appears to be safe and feasible for the treatment of newly diagnosed GBM. Given that therapy is delivered non-invasively and no device-related serious adverse events were reported, further prospective study of the investigational device is planned.
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Raja, Shilpa N., Jessica G. Swallow, Sean R. Bishop, Yen-Ting Chi, Ting Chen, Nicola H. Perry, Harry L. Tuller, and Krystyn J. Van Vliet. "Analysis of Electrochemomechanical Coupling in Non-Stoichiometric Oxide Thin Films." ECS Meeting Abstracts MA2018-01, no. 32 (April 13, 2018): 1933. http://dx.doi.org/10.1149/ma2018-01/32/1933.
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Non-stoichiometric oxides are used in a wide variety of applications including solid oxide fuel cells (SOFCs), lithium ion batteries (LIBs), gas sensors, and catalysis. Through the capacity of such materials to support large point defect concentrations, these functional oxides can readily store, transport, and exchange ions. An important consequence of this non-stoichiometry is a tendency toward chemomechanical coupling, particularly in the form of chemical expansion, or the coupling between material volume and defect concentration. Thin films of non-stoichiometric oxides are of particular interest in such device designs, given the potential for strain engineering. For example, it has been shown for several materials that tensile strain can increase the ionic conductivity or gas exchange reactivity for oxygen by up to an order of magnitude, potentially enabling enhanced device efficiency or decreased operating temperatures1. In electrochemical devices, chemical expansion can generate stress or strain that can lead to mechanical failure, and/or changes in mechanical properties including elastic moduli. Given the extreme environments and range of non-stoichiometric oxides in which chemical expansion can be expected, robust device design requires accurate, flexible, and rapid characterization of environmental conditions and materials that maximize (or minimize) chemical expansion in situ. However, methods used at present for characterizing chemomechanical expansion, such as dilatometry, synchrotron techniques, reflectometry, and others, are not amenable to thin films or are difficult to implement in standard laboratory settings. Recently, Swallow et al. described an approach for characterizing thin film non-stoichiometric oxide chemical expansion at high temperatures by way of electrochemically induced actuation that addresses the above needs2. That work characterized volume change within a fluorite film of PrxCe1-xO2-δ (PCO) and structural deflection of the PCO/YSZ (yttria-stablized zirconia) bilayer during electrochemical pumping of oxygen ions into the PCO film. It also demonstrated a positive attribute of such chemical expansion in the form of high temperature oxide actuators, which harness electrochemically generated chemical strain to produce measurable, nanoscale device deflections. The actuation produced ranged between 5-15 nm of displacement amplitude depending on the experimental conditions2. Here, we provide an extended and graphically rich analysis of electrical and mechanical response data from such experiments. We model the current and mechanical response of PCO to an electrochemical driving force using previously established defect equilibria and kinetic relationships for that oxide, demonstrating the contributions that material properties and sample geometries make to device deflection and electrochemical pumping. We also extend the measurement approach to an additional material system, the perovskite-structured oxide SrTi0.65Fe0,35O3-δ (STF) used as part of magnetic memory devices, gas transport membranes, and fuel cells. This case study demonstrates the broad applicability of this measurement method, as well as means to leverage chemical expansion effects at elevated temperatures for diverse actuating and functional devices. Yildiz, B. ‘Stretching’ the energy landscape of oxides—Effects on electrocatalysis and diffusion. MRS Bull. 39, 147–156 (2014). Swallow, J. G. et al. Dynamic chemical expansion of thin-film non-stoichiometric oxides at extreme temperatures. Nat Mater (2017). doi:10.1038/nmat4898
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Barkhoudarian, Garni, Michael Badruddoja, Nicholas Blondin, Ricky Chen, Sajeel Chowdhary, Charles Cobbs, Anthony Dowling, et al. "ACTR-68. FEASIBILITY STUDY OF THE EMULATE THERAPEUTICS™ VOYAGER SYSTEM IN PATIENTS WITH RECURRENT GLIOBLASTOMA (GBM)." Neuro-Oncology 21, Supplement_6 (November 2019): vi29. http://dx.doi.org/10.1093/neuonc/noz175.109.
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Abstract BACKGROUND The EMulate Therapeutics Voyager system is an investigational non-sterile, non-invasive, non-thermal, non-ionizing, portable, home-use medical device that uses a specific, localized ultra-low radio frequency energy (ulRFE®) cognate for the treatment of brain cancer. METHODS This ongoing, open-label, multi-center study (NAT-101) is being conducted in the US and Australia in patients with recurrent GBM. There are 3 treatment groups: 32 patients treated with Voyager alone, 43 patients treated with Voyager + Investigator’s choice of anti-cancer therapy, and 21 patients treated with Voyager+lomustine+/-bevacizumab. The objective of the study is to assess if the Voyager is a safe and feasible treatment for recurrent GBM. The primary outcome measure is safety, assessed by the incidence and evaluation of adverse events (AEs) associated with the Voyager. The secondary outcome measures are progression-free survival and overall survival. RESULTS Enrollment is closed, and long-term treatment and follow-up is ongoing. 96 patients were enrolled and treated. 82 patients reported at least one AE, and 18 AEs were assessed as device-related (mild-moderate; 12 headache, 2 vomiting, 1 nausea, 1 confusion, 1 insomnia, and 1 skin irritation). 31 patients reported at least one serious AE, and none were assessed as device-related. 33% of patients treated with Voyager alone and 36% of patients treated with Voyager + chemotherapy were progression-free after 6 months. 58% of patients treated with Voyager alone and 60% of patients treated with Voyager + chemotherapy remained alive after 6 months; median overall survival is 7 months (95% CI=4.4±14.3) in patients treated with Voyager alone and 10 months (95% CI=6.7±11.5) in patients treated with Voyager + chemotherapy. CONCLUSIONS The Voyager system appears to be safe and feasible for the treatment of recurrent GBM. Given that therapy is delivered non-invasively and no device-related serious adverse events were reported, further prospective study of the investigational device is planned.
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Joshi, Pankaj, Oliver Willekens, Xiaobing Shang, Jelle De Smet, Dieter Cuypers, Geert Van Steenberge, Jeroen Beeckman, Kristiaan Neyts, and Herbert De Smet. "Tunable light beam steering device using polymer stabilized blue phase liquid crystals." Photonics Letters of Poland 9, no. 1 (March 31, 2017): 11. http://dx.doi.org/10.4302/plp.v9i1.704.
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A polarization independent and fast electrically switchable beam steering device is presented, based on a surface relief grating combined with polymer stabilized blue phase liquid crystals. Switching on and off times are both less than 2 milliseconds. The prospects of further improvements are discussed. Full Text: PDF ReferencesD.C. Wright, et al., "Crystalline liquids: the blue phases", Rev. Mod. Phys. 61, 385 (1989). CrossRef H. Kikuchi, et al., "Polymer-stabilized liquid crystal blue phases", Nat. Mater. 1, 64 (2002). CrossRef Samsung, Korea, SID exhibition, (2008).J. Yan, et al., "Direct measurement of electric-field-induced birefringence in a polymer-stabilized blue-phase liquid crystal composite", Opt. Express 18, 11450 (2010). CrossRef L. Rao, et al., "A large Kerr constant polymer-stabilized blue phase liquid crystal", Appl. Phys. Lett. 98, 081109 (2011). CrossRef Y. Hisakado, et al., "Large Electro-optic Kerr Effect in Polymer-Stabilized Liquid-Crystalline Blue Phases", Adv. Mater. 17, 96 (2005). CrossRef K. M. et al., "Submillisecond Gray-Level Response Time of a Polymer-Stabilized Blue-Phase Liquid Crystal", J. Disp. Technol. 6, 49 (2010). CrossRef Y. Chen, et al., "Level set based topology optimization for optical cloaks", Appl. Phys. Lett. 102, 251106 (2013). CrossRef H. Choi, et al., "Fast electro-optic switching in liquid crystal blue phase II", Appl. Phys. Lett. 98, 131905 (2011). CrossRef Y.H. Chen, et al., "Polarization independent Fabry-Pérot filter based on polymer-stabilized blue phase liquid crystals with fast response time", Opt. Express 19, 25441 (2011). CrossRef Y. Li, et al., "Polarization independent adaptive microlens with a blue-phase liquid crystal", Opt. Express 19, 8045 (2011). CrossRef C.T. Lee, et al., "Design of polarization-insensitive multi-electrode GRIN lens with a blue-phase liquid crystal", Opt. Express 19, 17402 (2011). CrossRef Y.T. Lin, et al., "Mid-infrared absorptance of silicon hyperdoped with chalcogen via fs-laser irradiation", J. Appl. Phys. 113, (2013). CrossRef J.D. Lin, et al., "Spatially tunable photonic bandgap of wide spectral range and lasing emission based on a blue phase wedge cell", Optics Express 22, 29479 (2014). CrossRef W. Cao, et al., "Lasing in a three-dimensional photonic crystal of the liquid crystal blue phase II", Nat. Mat. 1, 111 (2002). CrossRef S.T. Hur, et al., "Liquid-Crystalline Blue Phase Laser with Widely Tunable Wavelength", Adv. Mater. 25, 3002 (2013). CrossRef A. Mazzulla, et al., "Thermal and electrical laser tuning in liquid crystal blue phase I", Soft. Mater. 8, 4882 (2012). CrossRef C.W. Chen, et al., "Random lasing in blue phase liquid crystals", Opt. Express 20, 23978 (2012). CrossRef O. Willekens, et al., "Ferroelectric thin films with liquid crystal for gradient index applications", Opt. Exp. 24, 8088 (2016). CrossRef O. Willekens, et al., "Reflective liquid crystal hybrid beam-steerer", Opt. Exp. 24, 1541 (2016). CrossRef M. Jazbinšek, et al., "Characterization of holographic polymer dispersed liquid crystal transmission gratings", J. Appl. Phys. 90, 3831 (2001). CrossRef C.C. Bowley, et al., "Variable-wavelength switchable Bragg gratings formed in polymer-dispersed liquid crystals", Appl. Phys. Lett. 79, 9 (2001). CrossRef Y.Q. Lu, et al., "Polarization switch using thick holographic polymer-dispersed liquid crystal grating", Appl. Phys. 95, 810 (2004). CrossRef J.J. Butler et al., "Diffraction properties of highly birefringent liquid-crystal composite gratings", Opt. Lett. 25, 420 (2000). CrossRef R.L. Sutherland et al., "Electrically switchable volume gratings in polymer-dispersed liquid crystals", Appl. Phys. Lett. 64, 1074 (1994). CrossRef X. Shang, et al., "Electrically Controllable Liquid Crystal Component for Efficient Light Steering", IEEE Photo. J. 7, 1 (2015). CrossRef J. Yan, et al., "Extended Kerr effect of polymer-stabilized blue-phase liquid crystals", Appl. Phys. Lett. 96, 071105 (2010). CrossRef H.S. Chen, et al., "Hysteresis-free polymer-stabilized blue phase liquid crystals using thermal recycles", Opt. Mat. Exp. 2, 1149 (2012). CrossRef J. Yan. et al., "Dual-period tunable phase grating using polymer stabilized blue phase liquid crystal", Opt. Lett. 40, 4520 (2015). CrossRef H.S. Chen, et al., "Hysteresis-free polymer-stabilized blue phase liquid crystals using thermal recycles", Opt. Mat. Exp. 2, 1149 (2012). CrossRef H.C. Cheng, et al., "Blue-Phase Liquid Crystal Displays With Vertical Field Switching", J. Disp. Technol. 8, 98 (2012). CrossRef
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del Castillo, Elisabetta, Fausto Cargnoni, Raffaella Soave, and Mario Italo Trioni. "Organic Spintronics: A Theoretical Investigation of a Graphene-Porphyrin Based Nanodevice." Magnetochemistry 6, no. 2 (June 18, 2020): 27. http://dx.doi.org/10.3390/magnetochemistry6020027.
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Spintronics is one of the most exciting applications of graphene-based devices. In this work Density Functional Theory is used to study a nanojunction consisting of two semi-infinite graphene electrodes contacted with an iron-porphyrin (FeP) molecule, which plays the role of spin filter for the incoming unpolarized electrons. The graphene-FeP contact closely resembles the recently synthesized porphyrin-decorated graphene [He et al., Nat. Chem. 2017, 9, 33–38]. The analysis of the spectral properties of the system shows a variation of the orbital occupancy with respect to the isolated FeP molecule and an hybridization with the delocalized states of the substrate, while the overall magnetic moment remains unchanged. Doping the electrodes with boron or nitrogen atoms induces a relevant rearrangement in the electronic structure of the junction. Upon B doping the current becomes significantly spin polarized, while N doping induces a marked Negative Differential Resistivity effect. We have also investigated the possible exploitation of the FeP junction as a gas sensor device. We demonstrate that the interaction of CO and O2 molecules with the Fe atom, while being strong enough to be stable at room temperature (2.0 eV and 1.1 eV, respectively), induces only minor effects on the electronic properties of the junction. Interestingly, a quenching of the spin polarization of the current is observed in the B-doped system.
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Rădoi, Mihăiță, and Petrică Ciotîrnae. "Design and Implementation of a Collaborative Communication Network for Video Conference Services." Journal of Military Technology 3, no. 1 (June 26, 2020): 11–16. http://dx.doi.org/10.32754/jmt.2020.1.02.
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Under the current global conditions, strong emphasis is put on saving resources and reducing costs, migrating to collaborative unified communications solutions and developing open-source Web applications. The secure video-conferencing system will mainly use VoIP and WebRTC technologies to make multimedia calls, allowing end-users mobile and remote access (MRA) and therefore to facilitate communication between different networks, as well as the accessibility and the interoperability with any type of technology and device. This article will analyze the scalable implementation of the real-time communications network, providing redundancy and load balancing, therefore ensuring the high availability of the entire collaborative communications system. The call control and the dial plan are done through the Unified Call Manager software and WebRTC videoconferencing external access functionality is provided by configuring Traversal Using Relays around NAT (TURN) service across the Expressway Series server pair (Core & Edge). The ability to manage and monitor virtual meetings remains the responsibility of the open-source management tools.
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Tung, Shu Chu, Wu Jeng Li, and Shih Miao Huang. "A Web-Based Android Supervisory Control System." Applied Mechanics and Materials 284-287 (January 2013): 3211–15. http://dx.doi.org/10.4028/www.scientific.net/amm.284-287.3211.
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This paper designs a web-based Android supervisory control system. Android controller is used as a local controller to fit into a supervisory control framework. The framework includes a central server, a SMS device attached to the server, multiple local controllers, a remote control program and a ladder logic computer-aided design program. The Android controller contains an Android mobile phone, a Wi-Fi wireless access point, a switch hut (or NAT) and multiple data acquisition modules. The Android mobile phone enters TCP/IP LAN through the Wi-Fi access point. The data acquisition modules with TCP/IP interface are plugged into the LAN, and read/written by the Android mobile phone with Modbus TCP. The Android controller communicates with supervisory server with a specific m2m protocol which is based on http protocol. Once an Android controller is connected to the supervisory control framework, it can be monitored and controlled remotely with any browser. A web-based home security system is constructed to demonstrate the usage of the web-based Android supervisory control system. The control laws for the home security system are partially implemented with ladder logics designed with a computer-aided program in the framework. With a supervisory server serving multiple Android controllers, Cloud home security service is formed.
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Muller, A., G. Carle, and A. Klenk. "Behavior and classification of NAT devices and implications for NAT traversal." IEEE Network 22, no. 5 (September 2008): 14–19. http://dx.doi.org/10.1109/mnet.2008.4626227.
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Dhere, Neelkanth G., Ashwani Kaul, and Helio Moutinho. "Effect of Location of Sodium Precursor on the Morphological and Device Properties of CIGS Solar Cells." MRS Proceedings 1538 (2013): 51–60. http://dx.doi.org/10.1557/opl.2013.1053.
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ABSTRACTSodium plays an important role in the development of device quality CIGS (Cu-In-Ga-Se) and CIGSeS (Cu-In-Ga-Se-S) chalcopyrite thin film solar cells. In this study the effect of location of sodium precursor on the device properties of CIGS solar cells was studied. Reduction in the surface roughness and improvement in the crystallinity and morphology of the absorber films was observed with increase in sodium quantity from 0 Å to 40 Å and to 80 Å NaF. It was found that absorber films with 40 Å and 80 Å NaF in the front of the metallic precursors formed better devices compared to those with sodium at the back. Higher open circuit voltages and short circuit current values were achieved for devices made with these absorber films as well.
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Marsal, S., H. Corominas, M. Lopez Lasanta, D. Reina-Sanz, C. Perez-Garcia, H. Borrell Paños, R. Sanmartí, et al. "SAT0133 PILOT CLINICAL STUDY OF A NON-INVASIVE AURICULAR VAGUS NERVE STIMULATION DEVICE IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1003.2–1004. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3315.
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Background:Despite the clinical benefit of current pharmacological treatments for rheumatoid arthritis (RA), there remains an unmet need for alternative treatment approaches. Vagus nerve stimulation (VNS) via an implanted device has been shown to attenuate RA disease severity in patients resistant to therapy,1as evidenced by a reduction in the DAS28-CRP score following a month of daily stimulation.Objectives:This pilot study investigated the safety and efficacy of a wearable (non-invasive) device that attaches to the outer ear to treat RA via electrical stimulation of the auricular branch of the vagus nerve.Methods:Patients with active RA (≥4 tender/swollen joints based on a 28-joint count, Disease Activity Score-28 with C-reactive protein (DAS28-CRP) >3.8, active synovitis detected on ultrasound and MRI) and inadequate response to conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), or csDMARD and biologic DMARDs (bDMARDs), were enrolled in this open-label study. Patients used the device for up to 30 minutes daily over the course of the 12-week study. The primary endpoint was the change in DAS28-CRP score at Week 12. Secondary endpoints included a safety analysis, proportion of patients achieving ACR20/50/70, the mean change in HAQ-DI and the proportion of patients achieving a HAQ-DI MCID of at least 0.22 over 12 weeks. Additionally, sleep scores were assessed using a visual analogue scale (0-100) at baseline and 12 weeks.Results:Thirty patients with active RA were enrolled, of which 27 patients completed the 12-week protocol. Three patients dropped out of the study: two patients decided to seek other treatment and one patient moved out of the country. Data for three additional patients was not included in this dataset as it was still being collected. Of the 24 patients with complete 12-week datasets, 88% were female, the average age was 54.9 years, mean disease duration was 7.3 years, and four patients had an inadequate response to one or two bDMARDs.The mean change in DAS28-CRP from baseline to Week 12 was -1.43 (p<0.05; Figure 1) and ACR20/50/70 response rates were 58.3%, 37.5%, and 16.7%, respectively (Figure 2). HAQ-DI change from baseline was -0.50 (p<0.05) at 12 weeks, and 15 out of 24 patients achieved an overall HAQ-DI reduction of 0.22 (62.5%). VAS sleep scores were significantly improved over the 12-week study. Scores for trouble falling asleep, awakened by pain at night, and awakened by pain in morning decreased by 64%, 70%, and 60%, respectively (p<0.05, n = 23). Three study adverse events (AEs) were reported: two device related AEs due skin irritation at the earpiece insertion site and one AE due to mucous accumulation in the throat.Figure 1Figure 2Average DAS28-CRP is shown for each study visit. Error bars indicate standard error of mean. Percentage of subjects meeting ACR20/50/70 at 12 weeks.Conclusion:In this pilot study, auricular stimulation was well tolerated and daily use over 12 weeks attenuated RA disease severity. Further evaluation in larger controlled studies are needed to confirm whether a non-invasive wearable device might offer an alternative approach for the treatment of RA.References:[1]Koopman FA, et al. (2016) Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis. Proc Nat Acad Sci 2016; 113: 8284–9.Disclosure of Interests:Sara Marsal: None declared, Héctor Corominas Speakers bureau: Abbvie, Lilly, Pfizer, Roche, Maria Lopez Lasanta: None declared, D Reina-Sanz: None declared, Carolina Perez-Garcia: None declared, Helena Borrell Paños Speakers bureau: Lilly, Novartis, MSD and Janssen, Raimón Sanmartí Speakers bureau: Abbvie, Eli Lilly, BMS, Roche and Pfizer, J. Narváez: None declared, Clara Franco-Jarava: None declared, Jose Antonio Narvaez: None declared, Juan Jose de Agustin: None declared, Vivek Sharma Shareholder of: Vorso Corp., Konstantinos Alataris Shareholder of: Vorso Corp., Mark C. Genovese Grant/research support from: Abbvie, Eli Lilly and Company, EMD Merck Serono, Galapagos, Genentech/Roche, Gilead Sciences, Inc., GSK, Novartis, Pfizer Inc., RPharm, Sanofi Genzyme, Consultant of: Abbvie, Eli Lilly and Company, EMD Merck Serono, Genentech/Roche, Gilead Sciences, Inc., GSK, Novartis, RPharm, Sanofi Genzyme, Matthew Baker Consultant of: Gilead, Vorso, Paid instructor for: Gilead
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Moldoveanu, Serban C., Jeff Zhu, and Nancy Qian. "Analysis of Traces of Tobacco-Specific Nitrosamines (TSNAs) in USP Grade Nicotine, E-Liquids, and Particulate Phase Generated by the Electronic Smoking Devices." Beiträge zur Tabakforschung International/Contributions to Tobacco Research 27, no. 6 (April 1, 2017): 86–96. http://dx.doi.org/10.1515/cttr-2017-0009.
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Summary The present study describes the development of a liquid chromatography tandem mass spectrometry (LC-MS/MS) technique for the analysis of trace levels of four tobaccospecific nitrosamines (TSNAs): nitrosoanabasine (NAB), nitrosoanatabine (NAT), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and nitrosonornicotine (NNN). The technique can be applied for the analysis of TSNAs in USP grade nicotine. Nicotine used in e-liquids for the electronic smoking devices is typically obtained from tobacco plant materials (Nicotiana tabacum, Nicotiana rustica) and, although it is purified, it contains besides nicotine low levels of several contaminants such as minor alkaloids. It also contains traces of TSNAs. Analysis of TSNAs in USP grade nicotine is a challenging task since the analyzed samples contain about 10+7–10+8 times more nicotine than individual TSNAs. Because the analyzed solutions cannot be diluted too much in order to keep the TSNAs level above the limit of quantitation (LOQ), even for apparently good chromatographic separations, the peak tailing of nicotine may generate interferences. The new method of analysis uses a Luna Omega 1.6 μm particles chromatographic column for separation and detection on a LC-MS/MS instrument with scheduled multiple reaction monitoring (Scheduled MRM). The levels of TSNAs in nicotine of USP purity from four commercial sources varied between 3 to 8 ng/g NAB, 4 to 20 ng/g NAT, 30 to 50 ng/g NNK, and 0.5 to 2 ng/g for NNN. Besides the analysis of TSNAs in nicotine, the technique has been applied successfully in the analysis of TSNAs in e-liquids and in particulate phase generated by the electronic smoking devices.
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Kong, David S., Todd A. Thorsen, Jonathan Babb, Scott T. Wick, Jeremy J. Gam, Ron Weiss, and Peter A. Carr. "Open-source, community-driven microfluidics with Metafluidics." Nature Biotechnology 35, no. 6 (June 2017): 523–29. http://dx.doi.org/10.1038/nbt.3873.
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Abstract Microfluidic devices have the potential to automate and miniaturize biological experiments, but open-source sharing of device designs has lagged behind sharing of other resources such as software. Synthetic biologists have used microfluidics for DNA assembly, cell-free expression, and cell culture, but a combination of expense, device complexity, and reliance on custom set-ups hampers their widespread adoption. We present Metafluidics, an open-source, community-driven repository that hosts digital design files, assembly specifications, and open-source software to enable users to build, configure, and operate a microfluidic device. We use Metafluidics to share designs and fabrication instructions for both a microfluidic ring-mixer device and a 32-channel tabletop microfluidic controller. This device and controller are applied to build genetic circuits using standard DNA assembly methods including ligation, Gateway, Gibson, and Golden Gate. Metafluidics is intended to enable a broad community of engineers, DIY enthusiasts, and other nontraditional participants with limited fabrication skills to contribute to microfluidic research.
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Bixio, R., A. Biglia, G. Virelli, A. Giollo, C. Montecucco, and M. Rossini. "AB0911-HPR ROLE OF MOBILE APPLICATIONS IN RHEUMATOLOGY CARE: A MULTICENTRIC SURVEY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1477.1–1478. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3545.
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Background:Although mobile health applications (apps) are becoming increasingly popular across several medical specialties, no data are available in rheumatology. The aim of this study is to investigate whether apps are routinely used by rheumatologists.Objectives:In our study we aim assess real-life use of mobile applications in rheumatology clinical activity and to evaluate mobile apps role in rheumatology training, in particular for residents, and clinical activity.Methods:We invited a non-selected sample of rheumatologists (consultants, residents and medical students committed to begin rheumatology residency) to participate in an anonymous web-based survey. This survey investigated mobile application use in rheumatology care and issues and concerns about mobile device use in rheumatology.Results:Sixty participants completed the survey (40% consultants, 48.3% residents, 11.7% students). 52/60 (86.7%) declared to use mobile apps during their work. More than 50% used apps at least once a day. Apps were mostly used for calculating clinical disease activity scores for chronic inflammatory arthritides. Most rheumatology residents stated that these apps could be a useful tool in medical training. However, using a smartphone during a clinical examination was deemed to be inappropriate by 26/60 (43.3%).Conclusion:Mobile apps as clinical tools are widespread among rheumatologists.References:[1]Newzoo Global Mobile Market Report 2019 | Light Version [Internet]. Newzoo. [cited 2021 Jan 23]. Available from: https://newzoo.com/insights/trend-reports/newzoo-global-mobile-market-report-2019-light-version/.[2]eHealth WGO for. mHealth: new horizons for health through mobile technologies: second global survey on eHealth [Internet]. World Health Organization; 2011 [cited 2021 Jan 4]. Available from: https://apps.who.int/iris/handle/10665/44607.[3]Grainger R, Townsley H, White B, Langlotz T, Taylor WJ. Apps for People With Rheumatoid Arthritis to Monitor Their Disease Activity: A Review of Apps for Best Practice and Quality. JMIR MHealth UHealth. 2017;5:e7.[4]Salaffi F, Farah S, Di Carlo M. Smartphone APPlications in the clinical care and management of Rheumatic Diseases. Acta Bio Medica Atenei Parm. 2018;89:7–26.[5]Maassen O, Fritsch S, Gantner J, Deffge S, Kunze J, Marx G, et al. Future Mobile Device Usage, Requirements, and Expectations of Physicians in German University Hospitals: Web-Based Survey. J Med Internet Res [Internet]. 2020 [cited 2021 Jan 23];22. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781804/.[6]Solomon DH, Rudin RS. Digital health technologies: opportunities and challenges in rheumatology. Nat Rev Rheumatol. Nature Publishing Group; 2020;16:525–35.[7]Adami G, Giollo A, Rossini M, Orsolini G, Benini C, Viapiana O, et al. Different fracture risk profile in patients treated with anti-osteoporotic drugs in real-life. Reumatismo. 2020;72:71–4.[8]Maurits M, Yuminaga H, Huizinga T, Knevel R. Mobile health applications in rheumatology: Could they improve our care and research? Int J Clin Rheumatol. Open Access Journals; 2019;14:44.Acknowledgements:We thank prof. Punzi for helping to spread the survey among Rete Reumatologica VenetaDisclosure of Interests:None declared
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Che Mat, Fauziah, Moh Yasin, Anas Abdul Latiff, and Sulaiman Wadi Harun. "Graphene Oxide Film as Passive Q-switcher in Erbium-doped Fiber Laser Cavity." Photonics Letters of Poland 9, no. 3 (September 30, 2017): 100. http://dx.doi.org/10.4302/plp.v9i3.755.
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All-fiber passively Q-switched fiber lasers have been demonstrated by using graphene oxide (GO) Q-switcher for possible applications in telecommunication, laser processing, fiber sensing and medical community. The GO material was obtained through a modified Hummers method from expanded acid washed graphite flakes and it was embedded into a polyvinyl alcohol (PVA) film to form a saturable absorber (SA) device. The Q-switched pulse operates at 1563.3 nm with a repetition rate that can be tuned from 44.33 kHz to 61.77 kHz as the pump power changes from 39 mW to 96 mW. The highest repetition rate of 61.77 kHz is achieved at a pump power of 96 mW and it is observed that the Q-switched pulse produced maximum pulse energy of 0.054 nJ and pulse width of 5.57 ?s at 96 mW pump power. Full Text: PDF ReferencesJ. Zayhowski and C. Dill, "Coupled-cavity electro-optically Q-switched Nd:YVO4 microchip lasers", Optics letters 20, 716 (1995). CrossRef C.-x. Gao, W. Zhao, Y.-s. Wang, S.-l. Zhu, G.-f. Chen, and Y.-g. Wang, "Passive Q-switched fiber laser with SESAM in ytterbium-doped double-clad fiber", 27th International congress on High-Speed Photography and Photonics, 62794G (2007). CrossRef M. Ahmed, N. Ali, Z. Salleh, A. Rahman, S. Harun, M. Manaf, "Q-switched erbium doped fiber laser based on single and multiple walled carbon nanotubes embedded in polyethylene oxide film as saturable absorber", Optics & Laser Technology 65, 25 (2015). CrossRef S. Harun, M. Ismail, F. Ahmad, M. Ismail, R. Nor, N. Zulkepely, et al., "A Q-switched erbium-doped fiber laser with a carbon nanotube based saturable absorber", Chinese Physics Letters 29, 114202 (2012). CrossRef A. Martinez and Z. Sun, "Nanotube and graphene saturable absorbers for fibre lasers", Nat Photon 7, 842 (2013). CrossRef J. Boguslawski, J. Sotor, G. Sobon, R. Kozinski, K. Librant, M. Aksienionek, et al., "Graphene oxide paper as a saturable absorber for Er- and Tm-doped fiber lasers", Photonics Research 3, 119 (2015). CrossRef H. Ahmad, F. D. Muhammad, M. Z. Zulkifli, and S. W. Harun, "Q-switched pulse generation from an all-f iber distributed Bragg reflector laser using graphene as saturable absorber", Chinese Optics Letters 11, 071401 (2013). CrossRef
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Blanco-Calvo, Moisés, Mar Haz-Conde, Teresa Rodríguez-Rigueiro, Angelica Figueroa, Margarita Reboredo, Vanessa Medina Villaamil, Maria J. Lorenzo-Patiño, et al. "MicroRNAs and response to anti-EGFR therapy in metastatic colorectal cancer." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): e21002-e21002. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21002.
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e21002 Background: The discovery of KRAS gene as response predictive factor to anti-EGFR antibodies supposed a revolution in the pharmacological management of metastatic colorectal cancer (mCRC) patients (pts), since only KRAS native (WT) pts are possible responders (R) and susceptible to be treated with this targeted therapy. However, the appearance of non-responders (NR) among KRAS WT pts during the administration of anti-EGFR therapy has stimulated the research in additional predictive markers. Here, we explore the putative role of microRNA (miRNA) deregulation as predictive tool of response to anti-EGFR therapy in mCRC pts. Methods: Tissue samples of mCRC were obtained as formalin-fixed paraffin-embedded (FFPE) specimens from the archives of our institution, after obtaining informed consent of pts. Genomic DNA was extracted using Qiaamp DNA mini kit (Qiagen). For the mutational testing of KRAS gene, we use the TheraScreen KRAS PCR kit (DxS, Qiagen). miRNA-containing total RNA was extracted using Tripure (Roche). miRNA expression was analyzed by SYBR-green-based RT-qPCR in a LightCycler 480 (Roche) device using the Human Cancer RT2 miRNA PCR array (SABiosciences, Qiagen). First data analysis was performed with the application provided by supplier (SABiosciences, Qiagen). Bioinformatic analyses were performed in miRBase 18, TargetScanHuman 6.0 and TarBase 6.0 databases. Additional statistical analyses were performed on R 2.14 (R Foundation), SPSS 19 (IBM) and Prism (GraphPad). Results: We analyze 9 primary colon cancer and 3 non-matched normal adjacent (NAT) tissues. Tumor samples corresponded to 6 KRAS WT and 3 KRAS mutated pts. Among KRAS WT pts, 3 had shown response to anti-EGFR antibodies and 3 did not. Samples were analyzed in duplicate for the expression of 88 cancer-related miRNAs. We found 22 miRNAs significantly (p<0.01) upregulated (>4-fold) when comparing KRAS WT NR versus R pts. From these 22 miRNAs, we detected only 6 when we search in databases for experimentally tested or predicted miRNA interactions with KRAS. Conclusions: We found a miRNA signature which could be utilized as response predictive tool for anti-EGFR therapy in mCRC pts. Further analysis will be necessary to establish the performance of this signature.
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Cho, Sung-Min, J. Hunter Mehaffey, Susan L. Meyers, Ryan S. Cantor, Randall C. Starling, James K. Kirklin, Jeffrey P. Jacobs, John Kern, Ken Uchino, and Leora T. Yarboro. "Cerebrovascular Events in Patients With Centrifugal-Flow Left Ventricular Assist Devices: Propensity Score–Matched Analysis From the Intermacs Registry." Circulation 144, no. 10 (September 7, 2021): 763–72. http://dx.doi.org/10.1161/circulationaha.121.055716d.
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Background: Ischemic and hemorrhagic cerebrovascular accidents remain common among patients with centrifugal-flow left ventricular assist devices, despite improvements in survival and device longevity. We compared the incidence of neurologic adverse events (NAEs) associated with 2 contemporary centrifugal-flow left ventricular assist devices: the Abbott HeartMate3 (HM3) and the Medtronic HeartWare HVAD (HVAD). Methods: Using the Society of Thoracic Surgeons Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), we collected data on adult patients who received a centrifugal-flow left ventricular assist device as a primary isolated implant between January 1, 2017, and September 30, 2019. Major NAEs were defined as transient ischemic attack, ischemic cerebrovascular accident, or hemorrhagic cerebrovascular accident. The association of HVAD with risk of NAE in the first year after implant was evaluated using propensity score matching to balance for preimplant risk factors. After matching, freedom from first major NAE in the HM3 and HVAD cohorts was compared with Kaplan-Meier curves. A secondary analysis using multivariable multiphase hazard models was used to identify predictors of NAE, which uses a data-driven parametric fit of the early declining and constant phase hazards and the associations of risk factor with either phase. Results: Of 6205 included patients, 3129 (50.4%) received the HM3 and 3076 (49.6%) received the HVAD. Median follow-up was 9 and 12 months (HM3 and HVAD, respectively). Patients receiving HVAD had more major NAEs (16.4% versus 6.4%, P <0.001) as well as each subtype (transient ischemic attack: 3.3% versus 1.0%, P <0.001; ischemic cerebrovascular accident: 7.7% versus 3.4%, P <0.001; hemorrhagic cerebrovascular accident: 7.2% versus 2.0%, P <0.001) than did patients receiving HM3. A propensity-matched cohort balanced for preimplant risk factors showed that HVAD was associated with higher probabilities of major NAEs (% freedom from NAE 82% versus 92%, P <0.001). Device type was not significantly associated with NAEs in the early hazard phase, but HVAD was associated with higher incidence of major NAEs during the constant hazard phase (hazard ratio, 5.71 [CI, 3.90–8.36]). Conclusions: HM3 is associated with lower hazard of major NAEs than is HVAD beyond the early postimplantation period and during the constant hazard phase. Defining the explanation for this observation will inform device selection for individual patients.
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Cho, Sung-Min, J. Hunter Mehaffey, Susan L. Meyers, Ryan S. Cantor, Randall C. Starling, James K. Kirklin, Jeffrey P. Jacobs, John Kern, Ken Uchino, and Leora T. Yarboro. "Cerebrovascular Events in Patients With Centrifugal-Flow Left Ventricular Assist Devices: Propensity Score–Matched Analysis From the Intermacs Registry." Circulation 144, no. 10 (September 7, 2021): 763–72. http://dx.doi.org/10.1161/circulationaha.121.055716.
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Background: Ischemic and hemorrhagic cerebrovascular accidents remain common among patients with centrifugal-flow left ventricular assist devices, despite improvements in survival and device longevity. We compared the incidence of neurologic adverse events (NAEs) associated with 2 contemporary centrifugal-flow left ventricular assist devices: the Abbott HeartMate3 (HM3) and the Medtronic HeartWare HVAD (HVAD). Methods: Using the Society of Thoracic Surgeons Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs), we collected data on adult patients who received a centrifugal-flow left ventricular assist device as a primary isolated implant between January 1, 2017, and September 30, 2019. Major NAEs were defined as transient ischemic attack, ischemic cerebrovascular accident, or hemorrhagic cerebrovascular accident. The association of HVAD with risk of NAE in the first year after implant was evaluated using propensity score matching to balance for preimplant risk factors. After matching, freedom from first major NAE in the HM3 and HVAD cohorts was compared with Kaplan-Meier curves. A secondary analysis using multivariable multiphase hazard models was used to identify predictors of NAE, which uses a data-driven parametric fit of the early declining and constant phase hazards and the associations of risk factor with either phase. Results: Of 6205 included patients, 3129 (50.4%) received the HM3 and 3076 (49.6%) received the HVAD. Median follow-up was 9 and 12 months (HM3 and HVAD, respectively). Patients receiving HVAD had more major NAEs (16.4% versus 6.4%, P <0.001) as well as each subtype (transient ischemic attack: 3.3% versus 1.0%, P <0.001; ischemic cerebrovascular accident: 7.7% versus 3.4%, P <0.001; hemorrhagic cerebrovascular accident: 7.2% versus 2.0%, P <0.001) than did patients receiving HM3. A propensity-matched cohort balanced for preimplant risk factors showed that HVAD was associated with higher probabilities of major NAEs (% freedom from NAE 82% versus 92%, P <0.001). Device type was not significantly associated with NAEs in the early hazard phase, but HVAD was associated with higher incidence of major NAEs during the constant hazard phase (hazard ratio, 5.71 [CI, 3.90–8.36]). Conclusions: HM3 is associated with lower hazard of major NAEs than is HVAD beyond the early postimplantation period and during the constant hazard phase. Defining the explanation for this observation will inform device selection for individual patients.
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Li, Li Erran, Aiyou Chen, Tian Bu, and Scott Miller. "Detecting subscribers using NAT devices in wireless data networks." Bell Labs Technical Journal 14, no. 2 (August 24, 2009): 223–33. http://dx.doi.org/10.1002/bltj.20381.
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Mol, Adam A., Florian Groher, Britta Schreiber, Ciaran Rühmkorff, and Beatrix Suess. "Robust gene expression control in human cells with a novel universal TetR aptamer splicing module." Nucleic Acids Research 47, no. 20 (September 2, 2019): e132-e132. http://dx.doi.org/10.1093/nar/gkz753.
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Abstract Fine-tuning of gene expression is desirable for a wide range of applications in synthetic biology. In this context, RNA regulatory devices provide a powerful and highly functional tool. We developed a versatile, robust and reversible device to control gene expression by splicing regulation in human cells using an aptamer that is recognized by the Tet repressor TetR. Upon insertion in proximity to the 5′ splice site, intron retention can be controlled via the binding of TetR to the aptamer. Although we were able to demonstrate regulation for different introns, the genomic context had a major impact on regulation. In consequence, we advanced the aptamer to develop a splice device. Our novel device contains the aptamer integrated into a context of exonic and intronic sequences that create and maintain an environment allowing a reliable and robust splicing event. The exon-born, additional amino acids will then be cleaved off by a self-cleaving peptide. This design allows portability of the splicing device, which we confirmed by demonstrating its functionality in different gene contexts. Intriguingly, our splicing device shows a high dynamic range and low basal activity, i.e. desirable features that often prove a major challenge when implementing synthetic biology in mammalian cell lines.
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Choongul Park, Kitae Jeong, Sungil Kim, and Youngseok Lee. "NAT Issues in the Remote Management of Home Network Devices." IEEE Network 22, no. 5 (September 2008): 48–55. http://dx.doi.org/10.1109/mnet.2008.4626232.
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Kitrou, Panagiotis, Marios Papasotiriou, Konstantinos Katsanos, Dimitrios Karnabatidis, Dimitrios S. Goumenos, and Evangelos Papachristou. "Recent developments in endovascular interventions to sustain vascular access patency in haemodialysis patients." Nephrology Dialysis Transplantation 34, no. 12 (December 5, 2018): 1994–2001. http://dx.doi.org/10.1093/ndt/gfy354.
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Abstract There is amassed evidence regarding the use of endovascular procedures for the treatment of vascular access stenosis and thrombosis. A review was conducted based on available randomized trials, cohort studies and retrospective analyses published after 2000 on endovascular treatment of dysfunctional and thrombosed vascular access, with an aim to illustrate the available device and procedural options. The use of paclitaxel-coated balloons, cutting balloons and covered stents is described in the field of vascular access stenosis. The broad spectrum of available devices and endovascular declotting procedures ranging from thrombolysis to thrombectomy is also discussed. Overall, in this review we demonstrate the increasing role of endovascular procedures in vascular access treatment and the improved patency outcomes provided by the implementation of novel endovascular devices. Moreover, the improvement of post-intervention primary patency rates after endovascular declotting procedures and the shift to more thrombectomy-dependent procedures over time is also highlighted. In conclusion, endovascular treatment of dialysis access stenosis and thrombosis has an established role, owing to the implementation of sophisticated devices, allowing, when needed, the simultaneous treatment of thrombosis and the underlying stenosis.
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Riau, Aung, Setiawan, Yang, Yam, Beuerman, Venkatraman, and Mehta. "Surface Immobilization of Nano-Silver on Polymeric Medical Devices to Prevent Bacterial Biofilm Formation." Pathogens 8, no. 3 (June 28, 2019): 93. http://dx.doi.org/10.3390/pathogens8030093.
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: Bacterial biofilm on medical devices is difficult to eradicate. Many have capitalized the anti-infective capability of silver ions (Ag+) by incorporating nano-silver (nAg) in a biodegradable coating, which is then laid on polymeric medical devices. However, such coating can be subjected to premature dissolution, particularly in harsh diseased tissue microenvironment, leading to rapid nAg clearance. It stands to reason that impregnating nAg directly onto the device, at the surface, is a more ideal solution. We tested this concept for a corneal prosthesis by immobilizing nAg and nano-hydroxyapatite (nHAp) on poly(methyl methacrylate), and tested its biocompatibility with human stromal cells and antimicrobial performance against biofilm-forming pathogens, Pseudomonas aeruginosa and Staphylococcus aureus. Three different dual-functionalized substrates—high Ag (referred to as 75:25 HAp:Ag); intermediate Ag (95:5 HAp:Ag); and low Ag (99:1 HAp:Ag) were studied. The 75:25 HAp:Ag was effective in inhibiting biofilm formation, but was cytotoxic. The 95:5 HAp:Ag showed the best selectivity among the three substrates; it prevented biofilm formation of both pathogens and had excellent biocompatibility. The coating was also effective in eliminating non-adherent bacteria in the culture media. However, a 28-day incubation in artificial tear fluid revealed a ~40% reduction in Ag+ release, compared to freshly-coated substrates. The reduction affected the inhibition of S. aureus growth, but not the P. aeruginosa. Our findings suggest that Ag+ released from surface-immobilized nAg diminishes over time and becomes less effective in suppressing biofilm formation of Gram-positive bacteria, such as S. aureus. This advocates the coating, more as a protection against perioperative and early postoperative infections, and less as a long-term preventive solution.
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Kim, Min Su, Min Gyu Kim, Jae-yoon Kang, Jae in Chung, Yu Ju Seo, Soo-Kyoung Park, Ki-Sang Rha, and Yong Min Kim. "Factors Affecting Automatic Positive Airway Pressure Therapy Adherence in Patients Who had Completed the 3-Month Compliance Assessment for Korean National Health Insurance Coverage." Sleep Medicine Research 12, no. 2 (December 31, 2021): 125–32. http://dx.doi.org/10.17241/smr.2021.00990.
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Background and Objective The numbers of prescriptions for continuous positive airway pressure and automatic positive airway pressure (APAP) machines have increased dramatically since the Korean government changed national health insurance coverage. This study examined adherence to APAP therapy in patients with obstructive sleep apnea who completed the 3-month adaptation period required by the insurance service, and evaluated the factors predictive of good adherence.Methods We retrospectively reviewed the medical records of a total of 315 patients who received APAP prescriptions between July 2018 and December 2019. After screening, 189 patients were analyzed. Patients were divided into an adherent (AD) group and a non-adherent (NAD) group based on 9 months’ APAP adherence. Patient demographics, medical history, body mass index and pretreatment polysomnography results, as well as APAP therapy adherence-related variables, the 90th percentile pressure, residual apnea hypopnea status, and type of devices or managers were compared between the two groups.Results We found mean usage times, mean pressures, days with ≥ 4 hours of use a day, and 90th percentile pressures differed significantly between the AD and NAD groups. The device-related data at months 1 and 3 and 9 were similar. One type of device performed differently compared to the other devices, but this did not affect adherence.Conclusions The mean pressure and 90th percentile pressure were the main determinants of adherence in patients who passed a 3-month compliance assessment conducted by the Korean National Institute of Health. The data on adherence at months 1, 3 and 9 were similar.
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Liu, Chanjuan, Yuan Liu, Enqiang Zhu, Qiang Zhang, Xiaopeng Wei, and Bin Wang. "Cross-Inhibitor: a time-sensitive molecular circuit based on DNA strand displacement." Nucleic Acids Research 48, no. 19 (October 12, 2020): 10691–701. http://dx.doi.org/10.1093/nar/gkaa835.
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Abstract Designing biochemical systems that can be effectively used in diverse fields, including diagnostics, molecular computing and nanomachines, has long been recognized as an important goal of molecular programming and DNA nanotechnology. A key issue in the development of such practical devices on the nanoscale lies in the development of biochemical components with information-processing capacity. In this article, we propose a molecular device that utilizes DNA strand displacement networks and allows interactive inhibition between two input signals; thus, it is termed a cross-inhibitor. More specifically, the device supplies each input signal with a processor such that the processing of one input signal will interdict the signal of the other. Biochemical experiments are conducted to analyze the interdiction performance with regard to effectiveness, stability and controllability. To illustrate its feasibility, a biochemical framework grounded in this mechanism is presented to determine the winner of a tic-tac-toe game. Our results highlight the potential for DNA strand displacement cascades to act as signal controllers and event triggers to endow molecular systems with the capability of controlling and detecting events and signals.
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Jung, Younchan, and Ronnel Agulto. "Integrated Management of Network Address Translation, Mobility and Security on the Blockchain Control Plane." Sensors 20, no. 1 (December 21, 2019): 69. http://dx.doi.org/10.3390/s20010069.
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Currently, the dual use of IPv4 and IPv6 is becoming a problem. In particular, Network Address Translation (NAT) is an important issue to be solved because of traversal problems in end-to-end applications for lots of mobile IoT devices connected to different private networks. The vertical model is typically used to solve NAT, mobility and security issues for them. However, the existing vertical model has limitations because it handles NAT, mobility and security management one by one. This paper proposes a Blockchain-based Integrated Network Function Management (BINFM) scheme where the NAT, mobility, and security management are handled at once. The proposed scheme is advantageous in that by using blockchain and the Query/Reply mechanism, each peer can easily obtain the necessary parameters required to handle the NAT, mobility, and security management in a batch. In addition, this paper explains how our proposed scheme guarantees secure end-to-end data transfers with the use of one time session key. Finally, it is proved that the proposed scheme improves performance on latency from the viewpoints of mobility and security compared to the existing vertical model.
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Insawang, Mekhala, Kongphope Chaarmart, and Tosawat Seetawan. "Development of Biosensors for Ethanol Gas Detection." Instrumentation Mesure Métrologie 21, no. 2 (April 30, 2022): 49–57. http://dx.doi.org/10.18280/i2m.210203.
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This work developed a biosensor for the measurement of ethanol gas in the air. The biosensors were synthesized by mixing signal layer materials containing SiO2 and polyimide (PI) substrates using the enzyme Alcohol Dehydrogenase (ADH) and coenzyme Nicotinamide Adenine Dinucleotide (NAD+) as a biosensor. The electrodes were coated on biosensors by DC magnetron sputtering method for test the response performance of the developed biosensors. The ADH/NAD+ was immobilized on the Ag electrode by Glutaric dialaehyde 25 wt. % cross-linking procedure. It was found that, alcohol biosensors can be exhibited sensing ethanol gas at even low concentrations from 300 ppb to very high concentrations up to 1900 ppm, response time 3 s, recovery times 1-2 minutes and good sensitivity. The SiO2 substrate has excellent, which provides significant advantages for wearable electronic device that compact, easy to use and reduce direct contact with alcoholics. The alcohol biosensors can adoption in next generation to other electronic devices, because easy to integrate, such as a module alcohol biosensor with wireless or the fabrication of the RCL circuit. Furthermore, the alcohol biosensors based on SiO2/Ag/ADH, PI/Ag/ADH is artificial intelligence strategy for stable practical wearable electronic devices.
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Zheng, Ling, Zhen Wei Wang, and Chang Song Zhao. "The NAC System in the Smart Grid Systems." Applied Mechanics and Materials 462-463 (November 2013): 924–28. http://dx.doi.org/10.4028/www.scientific.net/amm.462-463.924.
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During the process of the Smart Grid systems construction, the Safe Access Platform has an increasing important role. Not only could it meet the demand that people of power system can telecommute, but also provides different level of security mechanisms for various smart devices, such as Hand-hold Terminal System PDA, Ultra Mobile Personal Computer (UMPC) and Wireless Data Acquisition Terminal. Determining how to guarantee the internal security and meet the security requirements of access control based on roles is an important subject. The paper presents a new network access control system (NAC system) based on roles. According to the security metrics of the network access equipment (NAE), the NAC system has been designed and implemented to provide different safety strategies for different application scenarios. Besides, 802.1x and L2-IP are discussed specially as the most important key techniques of the implementation of the system.
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Nait Hamoud, Othmane, Tayeb Kenaza, and Yacine Challal. "Security in device‐to‐device communications: a survey." IET Networks 7, no. 1 (January 2018): 14–22. http://dx.doi.org/10.1049/iet-net.2017.0119.
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Jongerius, J. M., M. Bovenhorst, C. L. van der Poel, J. A. van Hilten, A. C. M. Kroes, J. A. van der Does, E. F. van Leeuwen, and R. Schuurman. "Evaluation of automated nucleic acid extraction devices for application in HCV NAT." Transfusion 40, no. 7 (July 2000): 871–74. http://dx.doi.org/10.1046/j.1537-2995.2000.40070871.x.
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Bernabé-Orts, Joan Miquel, Alfredo Quijano-Rubio, Marta Vazquez-Vilar, Javier Mancheño-Bonillo, Victor Moles-Casas, Sara Selma, Silvia Gianoglio, Antonio Granell, and Diego Orzaez. "A memory switch for plant synthetic biology based on the phage ϕC31 integration system." Nucleic Acids Research 48, no. 6 (February 21, 2020): 3379–94. http://dx.doi.org/10.1093/nar/gkaa104.
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Abstract Synthetic biology has advanced from the setup of basic genetic devices to the design of increasingly complex gene circuits to provide organisms with new functions. While many bacterial, fungal and mammalian unicellular chassis have been extensively engineered, this progress has been delayed in plants due to the lack of reliable DNA parts and devices that enable precise control over these new synthetic functions. In particular, memory switches based on DNA site-specific recombination have been the tool of choice to build long-term and stable synthetic memory in other organisms, because they enable a shift between two alternative states registering the information at the DNA level. Here we report a memory switch for whole plants based on the bacteriophage ϕC31 site-specific integrase. The switch was built as a modular device made of standard DNA parts, designed to control the transcriptional state (on or off) of two genes of interest by alternative inversion of a central DNA regulatory element. The state of the switch can be externally operated by action of the ϕC31 integrase (Int), and its recombination directionality factor (RDF). The kinetics, memory, and reversibility of the switch were extensively characterized in Nicotiana benthamiana plants.
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Myers, David R., Todd Sulchek, and Wilbur Lam. "Nanomechanics of Platelet Contractility." Blood 118, no. 21 (November 18, 2011): 2202. http://dx.doi.org/10.1182/blood.v118.21.2202.2202.
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Abstract Abstract 2202 Background: Blood clots are composed of fibrin, platelets, and other blood cells and proteins, which interact to prevent hemorrhage. Previous studies on clot formation have shown that the mechanical properties of clots have direct effects on hemostasis and thrombosis, and alterations of those clot mechanics are associated with disease. For example, clots are 50% stiffer and more resistant to dissolution in young patients with post-myocardial infarction (Collet, et al., Arterioscler Thromb Vasc Biol, 2006) than clots from healthy controls. Conversely, clots are softer and more prone to dissolution in patients with bleeding disorders (Hvas, et al., J. Thrombosis and Haemostasis, 2007). As such, understanding the mechanical properties of clots is vital to understand hemostasis and thrombosis. As platelets drive this contraction phenomenon, single platelet measurements are required to obtain a mechanistic understanding of the retraction process and to identify specific therapeutic targets for disease states in which platelet/clot retraction is pathologically altered. In addition, as fibrin has recently been shown to have extremely complex material and mechanical properties (Brown, et al., Science, 2009), single platelet studies would decouple the effects of fibrin from platelets when examining clot mechanics. However, few studies have focused on the biomechanical role of platelets in clot formation and clot mechanics, especially at the single cell level. The key barrier which has prevented the study of single platelets has been the lack of technology with the sufficient precision and sensitivity to both manipulate and measure individual platelets. To that end, we recently published the first study investigating platelet contractility at the single cell level using an atomic force microscope (AFM) (Lam, et al., Nat Mater, 2011) Results: An AFM enables precise measurements of force down to the pico-newton level. A mechanically well-defined, fibrinogen-coated cantilever is brought into contact with a platelet and then brought to a fibrinogen-coated surface as shown in Figure 1A. The platelet will contract and the resulting deflection of the cantilever is measured with high accuracy to determine the force applied by the platelet. From AFM studies, it was found that both the loading rate (Fig 1B) and maximum contraction force exerted by single platelets (Fig 1C) were a function of the mechanical stiffness of the cantilever. Furthermore, preliminary data using the same techniques is indicating that there may be a unique subpopulation of platelets which exhibit high-amplitude, oscillatory contraction as shown in Figure 1D. Conclusions and Ongoing Effort: Ours is the first reported data measuring platelet contraction at the single cell level and reveals that platelets are extremely “strong” contractile machines, especially when taking account their small size. In addition, we discovered that platelets can “sense” their mechanical microenvironment, adjusting their contractility accordingly. Based on this research, the overall theme of this proposed work is to quantitatively investigate how the biophysics interacts with the molecular biology of platelet contraction. However, our initial work and past research have shown that platelets within a given population exhibit varied behavior, and to truly obtain meaningful data, studies on large populations are necessary. We are developing a high-throughput device that is capable of individually measuring the contractility of thousands of platelets using the same principles as AFM. As this “biomechanical flow cytometer” leverages microfabrication techniques, it offers new capabilities to manipulate the platelet microenvironment while making contractility measurements. This device will use massively parallel sets of polymer cantilevers to measure individual platelet contractility with an integrated microfluidic delivery system (Figure 2). Platelets flowing in the microfluidic channel will be captured by a set of fibrinogen-coated cantilevers. As the platelet contracts, the deflection of the cantilever tip can be measured optically, which is correlated to the force with the cantilever spring constant. Leveraging the capabilities of this system to test multiple conditions simultaneously, we will vary shear stresses and expose platelet to different doses of different agonists and determine how these parameters affect contraction. Disclosures: No relevant conflicts of interest to declare.
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Orzechowski, Kamil, Marek Wojciech Sierakowski, Marzena Sala-Tefelska, Tomasz Ryszard Woliński, Olga Strzeżysz, and Przemysław Kula. "Investigation of Kerr effect in a blue phase liquid crystal using wedge-cell technique." Photonics Letters of Poland 9, no. 2 (July 1, 2017): 54. http://dx.doi.org/10.4302/plp.v9i2.738.
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In this work an alternative method for refractive index measurement of blue phase liquid crystal in the Kerr effect has been described. The proposed wedge method uses simple goniometric setup, allowing for direct index measurements for any wavelengths and index values. This is significant advantage comparing to other methods, usually having limitations of the measurement range as well as necessity complicated calculation to obtain refractive indices values. The results are reliable and agree well with the subject literature. Full Text: PDF ReferencesW. Cao et al., "Lasing in a three-dimensional photonic crystal of the liquid crystal blue phase II", Nat. Mater. 1, 111-113 (2002). CrossRef S. Meiboom, M. Sammon, W.F. Brinkman, "Lattice of disclinations: The structure of the blue phases of cholesteric liquid crystals", Phys. Rev. A. 27, 438 (1983). CrossRef S. Tanaka et al., "Double-twist cylinders in liquid crystalline cholesteric blue phases observed by transmission electron microscopy", Sci. Rep. 5, 16180 (2015). CrossRef Y. Li and S.-T. Wu, "Polarization independent adaptive microlens with a blue-phase liquid crystal", Opt. Express 19(9), 8045-8050 (2011). CrossRef N. Rong et al., "Polymer-Stabilized Blue-Phase Liquid Crystal Fresnel Lens Cured With Patterned Light Using a Spatial Light Modulator", J. of Disp. Technol. 12(10), 1008-1012 (2016). CrossRef J.-D. Lin et al., "Spatially tunable photonic bandgap of wide spectral range and lasing emission based on a blue phase wedge cell", Opt. Express 22(24), 29479-29492 (2014). CrossRef P. Joshi et al., "Tunable light beam steering device using polymer stabilized blue phase liquid crystals", Photon. Lett. Poland 9(1), 11-13 (2017). CrossRef Ch.-W. Chen et al., "Temperature dependence of refractive index in blue phase liquid crystals", Opt. Mater. Express 3(5), 527-532 (2013). CrossRef Y.-H. Lin et al., "Measuring electric-field-induced birefringence in polymer stabilized blue-phase liquid crystals based on phase shift measurements", J. Appl. Phys. 109, 104503 (2011). CrossRef J. Yan et al., "Direct measurement of electric-field-induced birefringence in a polymer-stabilized blue-phase liquid crystal composite", Opt. Express 18(11), 11450-11455 (2010). CrossRef K.A. Rutkowska, K. Orzechowski, M. Sierakowski, "Wedge-cell technique as a simple and effective method for chromatic dispersion determination of liquid crystals", Photon. Lett. Poland 8(2), 51-53 (2016). CrossRef O. Chojnowska et al., "Electro-optical properties of photochemically stable polymer-stabilized blue-phase material", J. Appl. Phys. 116, 213505 (2014). CrossRef J. Yan et al., "Extended Kerr effect of polymer-stabilized blue-phase liquid crystals", Appl. Phys. Lett. 96, 071105 (2010). CrossRef M. Chen et al., "Electrically assisting crystal growth of blue phase liquid crystals", Opt. Mater. Express 4(5), 953-959 (2014). CrossRef J. Kerr, Philos. Mag. 50, 337 (1875).
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Malattia, C., M. Carpaneto, M. Mazzoni, C. Lavarello, E. Fueri, S. Marra, A. Ravelli, and L. Nobili. "AB0992 CONNECTING SLEEP QUALITY, PAIN AND MOOD DISTURBANCES IN JUVENILE FIBROMYALGIA." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1789.2–1790. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6112.
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Background:Subjective sleep problems, including difficulties falling asleep, waking up, un-restorative sleep and daytime sleepiness are highly prevalent in patients with juvenile fibromyalgia (JFM). Sleep disturbances has been considered a consequence of severe pain and depression, but also in healthy individuals sleep deprivation is also a risk factor for the development of chronic widespread pain, tenderness and fatigue, suggesting the important role of sleep in pain control and in the pathophysiology of fibromyalgia.Objectives:To estimate the incidence of polysomnographic alterations in JFM and to explore the relationship between sleep problems and the musculoskeletal pain, fatigue and mood and anxiety disorders.Methods:21 patients (M 3; F 18; mean age 16,1) with JFM were included. The objective sleep quality was measured by overnight polysomnography (PSG) (using the EMBLETTA MPR PG device). PSG data were compared to age and sex-matched controls. The subjective sleep disturbances were assessed by the Sleep Condition Indicator (SCI). Musculoskeletal symptoms were evaluated by using the widespread pain index (WPI). Pain intensity was evaluated on a 0-10 visual analogical scale (PVAS). Fatigue was assessed by using the Symptom Severity (SS) questionnaire. Mood and anxiety disorders were evaluated by using the Children Depression Index (CDI) and the Multidimensional Anxiety Scale for Children (MASC). Comparison of categorical data was performed by means of the Fisher’s Exact test. The relationship between sleep quality and clinical symptoms were assessed using Spearman’s rank order correlation coefficient (rs). All statistical test were 2-sided and p values less than 0.05 were considered statistically significant.Results:Nineteen out of 21 (90.5%) patients complained subjective sleep disturbances and un-restorative sleep. Seven out of 21 (33.3%) patients had mood and anxiety disorders. Eight out of 21 patients (38.1%) showed an electroencephalographic pattern of alpha wave intrusion in slow wave sleep (SWS). SCI was significantly correlated to CDI score rs -0,775 (p≤0,0001), MASC 0,61 (p=0,005), WPI -0,731 (p=0,001), SSI 0,492 (p=0,038), PVAS -0,590 (p=0,006).Conclusion:A substantial percentage of JFM patients experience sleep disturbances, which are, correlated with the severity of the muscolskeletal sympotms and mood and anxiety disorders. One third of JFM patients have alpha intrusion in the SWS. The important role of sleep in pain control suggests that the development of treatments to improve sleep quality may lead to more effective management of fibromyalgia in the future.References:[1]Ting TV et. al 2010 American College of Rheumatology Adult Fibromyalgia Criteria for Use in an Adolescent Female Population with Juvenile Fibromyalgia. J Pediatr. 2016 Feb;169:181-7.[2]Choy EH. The role of sleep in pain and fibromyalgia. Nat Rev Rheumatol. 2015;11:513-20.[3]Roizenblatt S et al. Alpha sleep characteristics in fibromyalgia. Arthritis Rheum. 2001;44, 222–230.Disclosure of Interests:None declared
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Zhou, Yu-Hao, Ke Ma, Peng Xiao, Run-Ze Ye, Lin Zhao, Xiao-Ming Cui, and Wu-Chun Cao. "An Optimal Nucleic Acid Testing Strategy for COVID-19 during the Spring Festival Travel Rush in Mainland China: A Modelling Study." International Journal of Environmental Research and Public Health 18, no. 4 (February 12, 2021): 1788. http://dx.doi.org/10.3390/ijerph18041788.
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Western countries are experiencing surges in COVID-19 cases and deaths due to increasing public transportation during holiday seasons. This study aimed to explore whether mainland China will face an epidemic rebound during the Spring Festival holiday, when millions of Chinese people travel across the country, and investigate which nucleic acid testing (NAT) strategy is optimal to contain the epidemic. A microsimulation model was used to simulate SARS-CoV-2 transmission among railway travelers and evaluated the effects of various NAT strategies. An extended susceptible-exposed-infectious-recovered (SEIR) model was built to forecast local transmission during the Spring Festival period under different scenarios of testing strategies. The total number of infections, testing burden, and medical expenditure were calculated to devise an optimal strategy during the Spring Festival travel rush. Assuming the daily incidence of 20 per 10 million persons, our model simulated that there would be 97 active infections on the day of travel among 10 million railway passengers without NAT and symptom screening. Pre-travel testing could reduce the number of active infections. Compared with no NAT, testing passengers from risk tier 2–4 regions 3 days before travelling could significantly reduce the risk of transmission, and it is more economical and efficient than testing for all passengers.
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Meidan, Yair, Vinay Sachidananda, Hongyi Peng, Racheli Sagron, Yuval Elovici, and Asaf Shabtai. "A novel approach for detecting vulnerable IoT devices connected behind a home NAT." Computers & Security 97 (October 2020): 101968. http://dx.doi.org/10.1016/j.cose.2020.101968.
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Do, Thu Trang, Meera Stephen, Khai Leok Chan, Sergei Manzhos, Paul L. Burn, and Prashant Sonar. "Pyrrolo[3,2-b]pyrrole-1,4-dione (IsoDPP) End Capped with Napthalimide or Phthalimide: Novel Small Molecular Acceptors for Organic Solar Cells." Molecules 25, no. 20 (October 14, 2020): 4700. http://dx.doi.org/10.3390/molecules25204700.
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We introduce two novel solution-processable electron acceptors based on an isomeric core of the much explored diketopyrrolopyrrole (DPP) moiety, namely pyrrolo[3,2-b]pyrrole-1,4-dione (IsoDPP). The newly designed and synthesized compounds, 6,6′-[(1,4-bis{4-decylphenyl}-2,5-dioxo-1,2,4,5-tetrahydropyrrolo[3,2-b]pyrrole-3,6-diyl)bis(thiophene-5,2-diyl)]bis[2-(2-butyloctyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione] (NAI-IsoDPP-NAI) and 5,5′-[(1,4-bis{4-decylphenyl}-2,5-dioxo-1,2,4,5-tetrahydropyrrolo[3,2-b]pyrrole-3,6-diyl)bis(thiophene-5,2-diyl)]bis[2-(2-butyloctyl)isoindoline-1,3-dione] (PI-IsoDPP-PI) have been synthesized via Suzuki couplings using IsoDPP as a central building block and napthalimide or phthalimide as end-capping groups. The materials both exhibit good solubility in a wide range of organic solvents including chloroform (CF), dichloromethane (DCM), and tetrahydrofuran (THF), and have a high thermal stability. The new materials absorb in the wavelength range of 300–600 nm and both compounds have similar electron affinities, with the electron affinities that are compatible with their use as acceptors in donor-acceptor bulk heterojunction (BHJ) organic solar cells. BHJ devices comprising the NAI-IsoDPP-NAI acceptor with poly(3-n-hexylthiophene) (P3HT) as the donor were found to have a better performance than the PI-IsoDPP-PI containing cells, with the best device having a VOC of 0.92 V, a JSC of 1.7 mAcm−2, a FF of 63%, and a PCE of 0.97%.
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&NA;. "Access Devices." Journal of Infusion Nursing 34 (2011): S50—S53. http://dx.doi.org/10.1097/nan.0b013e31820318c9.
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Hernandez, Maria D., Mohammad D. Mansouri, Saima Aslam, Barry Zeluff, and Rabih O. Darouiche. "Efficacy of Combination of N-acetylcysteine, Gentamicin, and Amphotericin B for Prevention of Microbial Colonization of Ventricular Assist Devices." Infection Control & Hospital Epidemiology 30, no. 2 (February 2009): 190–92. http://dx.doi.org/10.1086/593205.
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We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.
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Meyer, Britt M., Dawn Berndt, Michele Biscossi, Melanie Eld, Ginger Gillette-Kent, Angie Malone, and Lorelle Wuerz. "Vascular Access Device Care and Management." Journal of Infusion Nursing 43, no. 5 (September 2020): 246–54. http://dx.doi.org/10.1097/nan.0000000000000385.
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&NA;. "Vascular Access Device Selection and Placement." Journal of Infusion Nursing 34 (2011): S37—S49. http://dx.doi.org/10.1097/nan.0b013e318203178b.
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