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Journal articles on the topic 'Naproxeno'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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1

Américo-Pinheiro, Juliana Heloisa Pinê, William Deodato Isique, Nádia Hortense Torres, Angela Aparecida Machado, Sérgio Luís de Carvalho, Walter Veriano Valério Filho, and Luiz Fernando Romanholo Ferreira. "Ocorrência de diclofenaco e naproxeno em água superficial no município de Três Lagoas (MS) e a influência da temperatura da água na detecção desses anti-inflamatórios." Engenharia Sanitaria e Ambiental 22, no. 3 (May 2017): 429–35. http://dx.doi.org/10.1590/s1413-41522017128719.

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RESUMO Os objetivos deste trabalho foram avaliar a presença e a concentração dos anti-inflamatórios diclofenaco e naproxeno em um córrego urbano localizado no município de Três de Lagoas, Mato Grosso do Sul, que recebe efluente de uma estação de tratamento de esgoto; e verificar a influência da temperatura da água na ocorrência dos fármacos em águas superficiais. Foi realizado monitoramento dos anti-inflamatórios e dos parâmetros temperatura, pH e oxigênio dissolvido na água durante 12 meses consecutivos (outubro de 2008 a setembro de 2009). Foram coletadas amostras de água mensalmente em seis pontos, representando diferentes seções do córrego. As amostras foram submetidas ao processo de extração em fase sólida e analisadas por cromatografia líquida de alta eficiência. Para verificar a influência da temperatura da água na ocorrência dos anti-inflamatórios diclofenaco e naproxeno nos ambientes aquáticos, utilizou-se um modelo de regressão logística do Statistical Analysis System versão 9.0. Os anti-inflamatórios diclofenaco e naproxeno foram detectados nos diferentes pontos monitorados no Córrego da Onça. Os demais parâmetros avaliados neste estudo foram comparados com os padrões de qualidade de água estabelecidos pela Resolução CONAMA nº 357/2005. A maior concentração do diclofenaco foi detectada no ponto localizado à jusante da estação de tratamento de esgoto do município, enquanto a maior concentração de naproxeno foi registrada na foz do córrego. A temperatura da água influencia de forma inversamente proporcional a ocorrência dos dois anti-inflamatórios no córrego, ou seja, quanto maior a temperatura do corpo hídrico, menor a probabilidade de detecção dos fármacos diclofenaco e naproxeno.
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2

Fernández-Ángel, I., and A. Buendía Eisman. "Erupción fija medicamentosa por naproxeno." FMC - Formación Médica Continuada en Atención Primaria 10, no. 4 (January 2003): 286. http://dx.doi.org/10.1016/s1134-2072(03)75898-8.

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Erba, Caroline Moço, Edson Pereira Tangerino, Sérgio Luis de Carvalho, and Willian Deodato Isique. "Remoção de diclofenaco, ibuprofeno, naproxeno e paracetamol em filtro ecológico seguido por filtro de carvão granular biologicamente ativado." Engenharia Sanitaria e Ambiental 17, no. 2 (June 2012): 137–42. http://dx.doi.org/10.1590/s1413-41522012000200002.

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O filtro ecológico representa uma promissora tecnologia de tratamento, em razão desta não necessitar da aplicação de produtos químicos, além de sua constatada eficiência. Nele, estabelece-se entre os seres vivos a relação de cadeia alimentar. Inicialmente uma matriz aquosa foi acrescida de quatro fármacos (diclofenaco, naproxeno, ibuprofeno e paracetamol) e posteriormente analisada por cromatografia líquida de alta eficiência para avaliar a remoção desses compostos pelo filtro ecológico seguido pelo filtro de carvão granular biologicamente ativado. Parâmetros, entre eles turbidez, coliformes totais e termotolerantes, cor aparente e cor verdadeira, foram mensurados para verificar a eficiência dos filtros. Houve remoção de 97,43% do diclofenaco, 85,03% do ibuprofeno: 94,11% do naproxeno e 84,07% do paracetamol.
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Bali, Cagla, Pinar Ergenoglu, Ozlem Ozmete, Sule Akin, Nesrin Bozdogan Ozyilkan, Oya Yalcin Cok, and Anis Aribogan. "Comparação dos efeitos analgésicos pós‐operatórios de naproxeno sódico e naproxeno sódico‐fosfato de codeína em artroscopia de menisco." Brazilian Journal of Anesthesiology 66, no. 2 (March 2016): 151–56. http://dx.doi.org/10.1016/j.bjan.2016.01.005.

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5

Jiménez-Bambague, Eliana M., Carlos A. Madera-Parra, and Enrique J. Peña-Salamanca. "Eliminación de compuestos farmacéuticos presentes en el agua residual doméstica mediante un tratamiento primario avanzado." INGENIERÍA Y COMPETITIVIDAD 22, no. 1 (January 29, 2020): 10. http://dx.doi.org/10.25100/iyc.v22i1.8794.

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Se evaluó la presencia de compuestos farmacéuticos de los grupos terapéuticos antiepilépticos, agentes hipolipemiantes, analgésicos antiinflamatorios y tranquilizantes en tres jornadas de muestreo, además se estimó la eficiencia de eliminación mediante un tratamiento primario avanzado (TPA) con procesos de coagulación, floculación y sedimentación en la planta de tratamiento de agua residual de la ciudad de Cali (Colombia). De los compuestos medidos, 10 estuvieron por encima del límite de detección de la técnica analítica usada: carbamazepina, 10,11-Dihidro-10,11-dihidroxicarbamazepina, gabapentina, ácido fenofíbrico, gemfibrozilo, diclofenaco, ibuprofeno, ketoprofeno, naproxeno y paracetamol, en concentraciones que oscilaron entre 0.15 y 10 µgL-1 en el afluente. Después del tratamiento, la mayoría de compuestos tuvieron eficiencias de eliminación inferiores al 30%, siendo el paracetamol y naproxeno los que obtuvieron los mejores porcentajes de 98.1 y 57.1%, respectivamente. Estas eficiencias de eliminación se relacionaron no solo al proceso de coagulación floculación, el cual es favorable para compuestos lipofílicos, sino también a la biodegradación por la acción de las bacterias presentes en la matriz de agua residual.
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Castro-Pastrana, L. I., M. Cerro-López, M. L. Toledo-Wall, L. M. Gómez-Oliván, and M. D. Saldívar-Santiago. "Análisis de fármacos en aguas residuales de tres hospitales de la ciudad de Puebla, México." Ingeniería del agua 25, no. 1 (January 29, 2021): 59. http://dx.doi.org/10.4995/ia.2021.13660.

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<p>Mediante sus efluentes, los hospitales contribuyen a la ocurrencia de microcontaminantes emergentes como los fármacos, en el agua. Este trabajo cuantificó la presencia de nueve fármacos en las aguas residuales de tres hospitales privados de México con 66, 92 y 120 camas, respectivamente. Las muestras se caracterizaron fisicoquímicamente y, empleando cromatografía líquida de alta resolución acoplada a espectrometría de masas (UPLC-MS/MS), se reportaron las siguientes concentraciones máximas promedio: paracetamol (38740.11±33832.15 ng/L), naproxeno (6321.42±11074.86 ng/L), ketorolaco (1429.80±237.94 ng/L), ibuprofeno (249.46±143.68 ng/L), ranitidina (149.60±303.70 ng/L), hidrocortisona (96.72±57.21 ng/L), dexametasona (33.02±41.23 ng/L), esomeprazol (22.85±24.12 ng/L) y omeprazol (22.50±23.97 ng/L). En aguas tratadas se detectó una reducción del 67 al 100% en los niveles de hidrocortisona, naproxeno, paracetamol y ranitidina. Los resultados obtenidos informan la presencia de fármacos que no habían sido reportados previamente en efluentes hospitalarios mexicanos y demuestran el impacto de las plantas de tratamiento, contribuyendo a la evidencia existente para impulsar acciones de regulación, innovación tecnológica y monitoreo.</p>
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Solon, Lílian Grace da Silva, Ana Isabel Maria de Oliveira, Graziene Lopes de Souza, Luiz Alberto Lira Soares, and Aurigena Antunes de Araújo. "Estudo de controle de qualidade físico-químico de suspensões orais manipuladas de naproxeno sódico." Revista de Ciências Médicas 21, no. 1/6 (June 6, 2013): 87. http://dx.doi.org/10.24220/2318-0897v21n1/6a1876.

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ObjetivoEste trabalho objetivou realizar um estudo comparativo de controle de qualidade entre a suspensão de referência de naproxeno sódico, Flanax®, denominada R, e suspensões obtidas de seis farmácias de manipulação na cidade de Natal, Rio Grande do Norte, denominadas A, B, C, D, E e F, com concentrações de 25mg/mL. Realizaram-se ensaios para determinação do teor, pH, homogeneidade, identificação, volume e características organolépticas.MétodosO método utilizado para o doseamento mostrou precisão, exatidão, linearidade e especificidade. ResultadosAs formulações obtidas nas farmácias B, C e E apresentaram teor abaixo das especificações farmacopeicas, enquanto a formulação F apresentou um teor acima do recomendado. Em relação ao pH, as suspensões C, E e F apresentaram valores fora das especificações. Quanto à homogeneidade, as amostras obtidas das farmácias C e E foram reprovadas. Observou-se que a maioria das amostras apresentou volume compatível ao rotulado, exceto a amostra C.ConclusãoOs resultados indicaram a necessidade de uma maior fiscalização pelos órgãos competentes, de forma a garantir a segurança do paciente e a qualidade dos medicamentos produzidos pelas farmácias de manipulação.Termos de indexação: Cromatografia líquida de alta pressão. Naproxeno. Preparações farmacêuticas.
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Meneses, Lorena, and Sebastián Cuesta. "Determinación Computacional de la Afinidad y Eficiencia de Enlace de Antinflamatorios No Esteroideos Inhibidores de la Ciclooxigenasa-2." Revista Ecuatoriana de Medicina y Ciencias Biológicas 36, no. 1-2 (August 15, 2017): 17–25. http://dx.doi.org/10.26807/remcb.v36i1-2.260.

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El presente es un estudio computacional de la interacción de diferentes antinflamatorios no esteroideos con la enzima Ciclooxigenasa 2 (COX-2). El objetivo fue determinar la afinidad con la cual los inhibidores estudiados se enlazan con el sitio activo de la enzima y calcular la eficiencia de enlace de los mismos. Además, comprobar la aplicabilidad de los métodos de acoplamiento molecular, en la determinación de moléculas prometedoras, que aceleren los estudios de descubrimiento de nuevos fármacos. Se utilizaron métodos de dinámica molecular, para modelar las interacciones entre la enzima COX-2 y los sustratos celecoxib, diclofenaco, etoricoxib, indometacina, ibuprofeno, meloxicam y naproxeno, por medio del programa Autodock VINA. Los resultados muestran que la molécula que posee una mayor afinidad con la COX-2 es el celecoxib, con una energía de enlace de -10.8 kcal/mol y una constante de equilibrio Ki de 1.21x10-8 M. El ibuprofeno y el naproxeno son las moléculas con mayor eficiencia de enlace, con un valor mayor a -0.48 kcal/mol/átomos (no hidrógeno). Esto demuestra que una molécula que tiene una buena afinidad, no necesariamente debe tener una buena eficiencia de enlace. Estos valores dan una pauta para poder elegir la mejor molécula para inhibir la enzima COX-2 y en casos de descubrimiento de fármacos, la molécula idónea para invertir en su mejoramiento y optimización, para convertirla en un fármaco aprobado.
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Meneses, Lorena, and Sebastián Cuesta. "Determinación Computacional de la Afinidad y Eficiencia de Enlace de Antinflamatorios No Esteroideos Inhibidores de la Ciclooxigenasa-2." Revista Ecuatoriana de Medicina y Ciencias Biológicas 36, no. 1-2 (August 15, 2017): 17–25. http://dx.doi.org/10.26807/remcb.v36i1-2.62.

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El presente es un estudio computacional de la interacción de diferentes antinflamatorios no esteroideos con la enzima Ciclooxigenasa 2 (COX-2). El objetivo fue determinar la afinidad con la cual los inhibidores estudiados se enlazan con el sitio activo de la enzima y calcular la eficiencia de enlace de los mismos. Además, comprobar la aplicabilidad de los métodos de acoplamiento molecular, en la determinación de moléculas prometedoras, que aceleren los estudios de descubrimiento de nuevos fármacos. Se utilizaron métodos de dinámica molecular, para modelar las interacciones entre la enzima COX-2 y los sustratos celecoxib, diclofenaco, etoricoxib, indometacina, ibuprofeno, meloxicam y naproxeno, por medio del programa Autodock VINA. Los resultados muestran que la molécula que posee una mayor afinidad con la COX-2 es el celecoxib, con una energía de enlace de -10.8 kcal/mol y una constante de equilibrio Ki de 1.21x10-8 M. El ibuprofeno y el naproxeno son las moléculas con mayor eficiencia de enlace, con un valor mayor a -0.48 kcal/mol/átomos (no hidrógeno). Esto demuestra que una molécula que tiene una buena afinidad, no necesariamente debe tener una buena eficiencia de enlace. Estos valores dan una pauta para poder elegir la mejor molécula para inhibir la enzima COX-2 y en casos de descubrimiento de fármacos, la molécula idónea para invertir en su mejoramiento y optimización, para convertirla en un fármaco aprobado.
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Ragassi, Bruna, Juliana Heloisa Pinê Américo-Pinheiro, William Deodato Isique, and Osmar Pereira da Silva Junior. "MONITORAMENTO E REMOÇÃO DE ANTI-INFLAMATÓRIOS EM ESTAÇÃO DE TRATAMENTO DE ESGOTO COM LAGOAS DE ESTABILIZAÇÃO." Revista Brasileira de Ciências Ambientais (Online), no. 53 (February 3, 2020): 1–12. http://dx.doi.org/10.5327/z2176-947820190502.

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O monitoramento dos fármacos residuais no ambiente vem ganhandoatenção, pois são frequentemente detectados em estações de tratamentode esgoto (ETE) e atingem os corpos hídricos. Portanto, o objetivo destetrabalho foi avaliar a presença, a concentração e a porcentagem de remoçãode anti-inflamatórios em amostras de esgoto bruto e efluente tratado da ETEdo município de Dracena (SP). Foram avaliados dois pontos de coletas naETE denominados de P1 (esgoto bruto) e P2 (efluente tratado). As coletas eanálises foram realizadas nos meses de março de 2017 a fevereiro de 2018.As amostras foram preparadas por microextração líquido–líquido dispersivae analisadas por cromatografia líquida de alta eficiência. A presença dosfármacos diclofenaco, ibuprofeno e naproxeno foi detectada nos doispontos analisados da ETE. O ibuprofeno foi o composto que apresentou amaior concentração no esgoto bruto (95,92 μg.L-1). Nos meses de inverno,foram registradas as menores concentrações dos anti-inflamatórios noesgoto bruto e as menores porcentagens de remoção dos fármacos na ETE.No mês de julho, o ibuprofeno e o naproxeno não foram detectados em P1nem em P2. A presença desses fármacos no esgoto bruto é atribuída aodescarte de medicamentos em pias e vasos sanitários, além da excreção viafezes e urina com resíduos de fármacos que não são totalmente absorvidospelo organismo humano. O tratamento de esgoto doméstico por meio delagoas de estabilização não remove totalmente esses anti-inflamatórios,propiciando o aporte dessas substâncias nas águas superficiais, alterandosua qualidade.
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Freitas, Sara, and Joana Marques. "Un caso de exantema fijo medicamentoso causado por Diclofenaco y Naproxeno." Galicia Clínica 82, no. 1 (2021): 64. http://dx.doi.org/10.22546/60/2143.

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12

Ortiz, Mario I., Gabriela Murguía-Cánovas, Laura C. Vargas-López, Rodolfo Silva, and Mario González-de la Parra. "Naproxen, paracetamol and pamabrom versus paracetamol, pyrilamine and pamabrom in primary dysmenorrhea: a randomized, double-blind clinical trial." Medwave 16, no. 09 (October 24, 2016): e6587-e6587. http://dx.doi.org/10.5867/medwave.2016.09.6587.

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Ariede, Jovita Ramos, Lilian Perilio, Luiz Gustavo Borsetti Ballestero, and Miriane Da Costa Gileno. "Efeito da Dipirona, do Naproxeno e do Diclofenaco de Potássio sobre Células Sanguíneas." Revista Brasileira Multidisciplinar 12, no. 2 (January 16, 2009): 89. http://dx.doi.org/10.25061/2527-2675/rebram/2009.v12i2.160.

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Na terapêutica, os anti-inflamatórios não esteróides (Aines) são muito utilizados para tratamento de estados inflamatórios leves e para desordens músculo-esqueléticas severas. No entanto, alguns efeitos adversos podem ocorrer devido a sua utilização, como agranulocitose, leucopenia e anemia aplástica. Objetivos: avaliar o efeito de alguns Aines na produção leucocitária; avaliar possível alteração dos grânulos dos neutrófilos; e comparar a contagem global de leucócitos por metodologia manual e automatizada. Foram analisadas 42 amostras de sangue total de ratos fêmeas da raça Wistar. Os animais ingeriram soluções de diclofenaco (DC), dipirona (DP) e naproxeno (NX) em duas concentrações: a plasmática terapêutica e outra dez vezes mais concentrada, durante cinco dias. Foi realizada a contagem diferencial em esfregaço corado e contaram-se leucócitos utilizando metodologia manual com Câmara de Neubauer e por metodologia automatizada (Coulter T-890). Na comparação entre os métodos, não se observaram diferenças significativas em nenhum grupo analisado. Com relação ao número global de leucócitos, também não foram constatadas alterações significativas entre os grupos. Quanto à contagem diferencial, observamos um aumento significativo no número de linfócitos atípicos encontrados no grupo tratado com DP diluída. O presente estudo demonstrou que a dipirona: 1) funcionou como agente tóxico devido à ativação linfocitária e ao grande número de neutrófilos com picnose nuclear; 2) o Coulter T-890 pode ser utilizado para a contagem global de leucócitos de animais; 3) os demais anti-inflamatórios estudados não causaram alterações hematológicas.
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Correia, João Vítor, Pedro Henrique Silva, Keila Angélica Peron, and Eny Maria Vieira. "Determinação das condições cromatográficas para a análise de diclofenaco, ibuprofeno e naproxeno em efluentes." Brazilian Journal of Development 6, no. 6 (2020): 33624–29. http://dx.doi.org/10.34117/bjdv6n6-061.

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Capel, Margarita, Jesús Tornero, José Luis Zamorano, Itziar Oyagüez, Miguel Ángel Casado, Joaquín Sánchez-Covisa, and Ángel Lanas. "Eficiencia de la combinación naproxeno/esomeprazol para el tratamiento de la artrosis en España." Reumatología Clínica 10, no. 4 (July 2014): 210–17. http://dx.doi.org/10.1016/j.reuma.2013.11.009.

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Pasquini, Nilton Cesar. "Monitoramento de fármacos no Ribeirão Quilombo, estado de São Paulo, BR." Saúde e meio ambiente: revista interdisciplinar 5, no. 1 (August 18, 2016): 63–77. http://dx.doi.org/10.24302/sma.v5i1.841.

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O monitoramento de fármacos residuais em rios e lagos vêm ganhando atenção dos pesquisadores e da população mundial. Este trabalho monitorou os fármacos antiinflamatório diclofenaco, ibuprofeno, naproxeno, paracetamol, piroxicam e os β-bloqueadores atenolol, metoprolol, nadolol, propranolol no Ribeirão Quilombo que abrange os municípios de Campinas, Hortolândia, Sumaré, Nova Odessa e Americana, estado de São Paulo-BR, desaguando no Rio Piracicaba no estado de São Paulo. A quantificação foi realizada por cromatografia gasosa (GC-MS/MS), acoplado a um espectrômetro de massas. Avaliando os pontos podemos concluir que o ponto SU/NO apresentou as maiores concentrações. Pouco se sabe sobre o efeito do Atenolol, Metoprolol, Nadolol e Propranolol no meio ambiente aquático e seus efeito ecotoxicológicos. Este estudo mostra que o Ribeirão Quilombo é castigado e consecutivamente leva este castigo para o Rio Piracicaba.
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Chacón-Carrión, Roberto Iván, Angel Steven Asmat-Abanto, and Rosita Elena Espejo-Carrera. "Efectividad Analgésica de Naproxeno Sódico y Etoricoxib Post Extracción Dental Simple: Ensayo Clínico Aleatorizado Paralelo." International journal of odontostomatology 13, no. 2 (June 2019): 241–46. http://dx.doi.org/10.4067/s0718-381x2019000200241.

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Alean Flórez, Joel, Daniela Márquez Méndez, Saudith María Burgos Núñez, Germán Enamorado-Montes, and José Marrugo Negrete. "Productos farmacéuticos y de cuidado personal presentes en aguas superficiales, de consumo humano y residuales en el departamento de Córdoba, Colombia." Revista de Investigación Agraria y Ambiental 12, no. 2 (June 2, 2021): 179–97. http://dx.doi.org/10.22490/21456453.4231.

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Contextualización: gracias al avance de técnicas analíticas sensibles desarrolladas en las últimas décadas, se ha podido identificar y cuantificar la presencia de diversos contaminantes en el medio acuático, dentro de este grupo se encuentran los contaminantes emergentes (CE) conformados por productos de cuidado e higiene personal, antibióticos, hormonas, plastificantes, fármacos y otros que son vertidos a las fuentes de agua alterando el equilibrio de estos ecosistemas. Vacío de investigación: diversas investigaciones muestran que los contaminantes emergentes pueden comprometer la vida acuática y la salud humana. A la fecha en la ciudad de montería y en el departamento de Córdoba no se encuentran reportados ningún estudio que permita evidenciar la presencia de contaminantes emergentes en agua superficial, de consumo humano y residual. Propósito del estudio: el presente estudio, tuvo como objetivo evaluar la presencia de cinco contaminantes emergentes comunes: naproxeno, ibuprofeno, gemfibrozilo, cafeína y triclosán en muestras de agua de consumo humano, residual y superficial colectadas al norte del país, representando así uno de los primeros estudios en reportar la presencia de estos compuestos en fuentes hídricas en esta región. Metodología: se empleó extracción en fase sólida (SPE) para el análisis de las muestras de agua, la detección y cuantificación se realizó por cromatografía líquida de alta eficacia con detector de arreglo de diodo y fluorescencia molecular (HPLC-DAD-FLD). Resultados y conclusiones: el ibuprofeno fue el compuesto que se encontró con mayor frecuencia en las muestras de agua, caso contrario al triclosán, que fue el menos detectado (2.25 µg/L); se halló cafeína en un máximo de 43.38 µg/L mientras que las concentraciones de naproxeno e ibuprofeno estuvieron entre 0.047 y 10.21 µg/L, resaltando la presencia de ibuprofeno y gemfibrozilo en agua de consumo humano. Estos resultados manifiestan la presión antropogénica ejercida sobre los compartimientos acuáticos, convirtiéndose en un problema ambiental que compromete la dinámica y servicios ecosistémicos. Se encontró que las plantas de abastecimiento de agua no tienen en cuenta la presencia de estos compuestos en sus sistemas de potabilización, lo cual podría constituirse un problema de salud pública en un futuro.
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Salas Acosta, Elizabeth, Mireya Salas de González, and Melissa González-Salas. "Factores de riesgo y prevalencia de trastornos migrañosos en población adulta. Estrategias médicas desde la atención primaria comunitaria." Revista Científica de Ciencias de la Salud 14, no. 1 (July 19, 2021): 9–18. http://dx.doi.org/10.17162/rccs.v14i1.1477.

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Objetivo: Determinar los factores de riesgo para trastornos migrañosos, presentes en población adultahacia el establecimiento de estrategias médicas para su prevención y tratamiento desde la atenciónprimaria comunitaria. Metodología: El estudio se desarrolló a través de una investigación tipo descriptivoy de campo, con una muestra de 64 pacientes, determinada a través de un muestreo no probabilísticointencional. Se diseñó un Cuestionario como instrumento de recolección de datos, cuya validaciónde contenido por medio de nueve expertos resultó suficiente. En el tratamiento estadístico se utilizóel programa Excel 2007 y SPSS versión 23, con un procedimiento tipo descriptivo, de frecuencias,sumatorias, media aritmética y porcentajes, representados en cuadros frecuenciales por indicadores.Resultados: Se demuestra prevalencia de antecedentes familiares en migraña, mientras que lascaracterísticas del dolor fue hemicraneal, pulsátil, intensidad moderada, insidioso, evolución con más de5 años, siendo el naproxeno el medicamento más utilizado. Prevalencia de migraña sin aura en el sexofemenino entre las edades 31 a 60 años. El síntoma más experimentado además del dolor fue de vómitos/nauseas. Conclusión: Se llega a la conclusión según los resultados que el mayor factor de riesgodesencadenante de la migraña fue de factores ambientales, traducido en la alta sensación térmica. Serecomienda la aplicación de lineamientos de estrategias locales en la promoción y prevención de salud.
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ABDULLAH, U. A. A. UNGKU, N. S. MOHAMAD HANAPI, W. N. W. IBRAHIM, S. SAIFUL AZHAR, N. S. ISHAK, and R. D. HAMID. "Rapid Magnetic Solid-Phase Extraction Based on Graphene Oxide/Magnetite Nanoparticles for the Determination of Non-Steroidal Anti-Inflammatory Drugs and Bisphenol-A in Tap Water." Asian Journal of Chemistry 31, no. 6 (April 29, 2019): 1294–300. http://dx.doi.org/10.14233/ajchem.2019.21899.

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A simple and rapid magnetic solid-phase extraction based on reduced graphene oxide/ferroferic oxide (rGO/Fe3O4) coupled with high performance liquid chromatography-diode array detector (HPLC-DAD), was proposed for the determination of naproxen and diclofenac sodium of non-steroidal anti-inflammatory drugs (NSAIDs) and bisphenol-A residue in tap water sample. Fe3O4 was assembled with graphene oxide by facile method. Several important parameters, such as extraction time, desorption time and desorption solvent were studied and optimized. Optimal conditions were then used for the extraction of NSAIDs and bisphenol-A from real samples, prior to HPLC-DAD analysis using C18 column. The proposed method provides good linearity in the range of 1.0-5.0 mg L-1 (R2 naproxene = 0.9983, R2 diclofenac = 0.9960) for NSAIDs and R2 = 0.9919 for bisphenol-A; limit of detection of 0.031 mg L-1 and 0.023 mg L-1 for naproxen and diclofenac, respectively and 0.1785 mg L-1 for bisphenol-A; limit of quantification for naproxen and diclofenac were 0.102 and 0.076 mg L-1, respectively and 0.5949 mg L-1 for bisphenol-A; relative recoveries between 66.21 and 105.60 % for diclofenac and naproxen, respectively and 72.74 % for bisphenol-A; and acceptable reproducibility relative standard deviation (RSD, n = 3) of 6.79 and 11.32 % for diclofenac and naproxen, respectively and 0.93 % for bisphenol-A. The method was successfully applied to tap water sample and the results indicates that small residue of bisphenol-A is present the sample while no traces of NSAIDs was detected.
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Borges, Rívea Medri, Alessandro Minillo, Eliana Gertrudes de Macedo Lemos, Heloiza Ferreira Alves do Prado, and Edson Pereira Tangerino. "Uso de filtros de carvão ativado granular associado a microrganismos para remoção de fármacos no tratamento de água de abastecimento." Engenharia Sanitaria e Ambiental 21, no. 4 (September 5, 2016): 709–20. http://dx.doi.org/10.1590/s1413-41522016118787.

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RESUMO O modo de vida das sociedades modernas originou o aporte diário, nos ambientes aquáticos, de fármacos e outras inúmeras moléculas de uso contínuo, compostos emergentes, com potencial de risco à saúde humana principalmente pela exposição em razão da inevitável contaminação dos mananciais de abastecimento de água e da transferência para as estações de tratamento de água (ETA), onde não são removidos. O uso de carvão ativado granular na filtração demonstra ser uma opção viável para ETA, porém, uma eficiência satisfatória requer regeneração periódica do material, onerando o tratamento. Contudo, observa-se que em baixas taxas de filtração a colonização natural dos filtros por microrganismos - formação de biofilme - pode ser uma alternativa para aumentar o tempo de vida útil do carvão, bem como para decompor essas moléculas complexas em elementos minerais assimiláveis, reintroduzindo-os nos ciclos biogeoquímicos naturais. Este trabalho avaliou, durante 24 semanas, em condições de laboratório, o carvão ativado com biofilme como meio filtrante para remoção dos fármacos: diclofenaco de sódio, ibuprofeno, naproxeno e amoxicilina; experimentou em sistema batch o potencial dos microrganismos colonizadores de filtros em degradar os fármacos testados, assim como identificou filogeneticamente os microrganismos predominantes na biodegradação. Os resultados demonstram a remoção dos fármacos acima de 80%. Constatou-se a presença das bactérias dos gêneros Bacillus , Burkholderia , Cupriavidus , Pseudomonas , Shinella , e Sphingomonas . Este estudo permite inferir a capacidade de remoção de fármacos por bactérias presentes em filtros de carvão ativado e o possível uso dessa tecnologia como alternativa de controle e remoção dessas substâncias no tratamento de água potável.
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Graos Salazar, Karin Maria, and Miguel Perea Paz. "Medicación analgésica postquirúrgica en pacientes atendidos en el Servicio de Odontología Pediátrica de la Clínica Estomatológica Central Cayetano Heredia (2000-2004)." Revista Estomatológica Herediana 17, no. 2 (September 17, 2014): 53. http://dx.doi.org/10.20453/reh.v17i2.1858.

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El presente estudio tuvo como propósito determinar la frecuencia en el uso de medicamentos analgésicos posquirúrgicos prescritos en pacientes atendidos en un Servicio de Odontología Pediátrica. El grupo estuvo constituido por 91 historias clínicas de pacientes pediátricos sometidosa intervenciones quirúrgicas menores en el periodo del 2000 al 2004. La distribución de la muestra según sexo fue: 37,4% mujeres y 62,6% varones siendo el promedio de edad 8,82+2,43 años. En el análisis de los resultados se utilizo la distribución de frecuencia para determinar lostipos de cirugía, tipo y número de fármacos. Los resultados revelan que la exodoncia de dientes supernumerarios fue la cirugía más frecuente en ambos sexos (47,4%). En relación a los tipos de cirugía oral según edad la exodoncia de diente supernumerario fue más frecuente en niños de 7 a11 años (53,1%); mientras que la frenectomia lingual fue la más frecuente en niños de 4 a 6 años.De las 91 HC solo 57 registraron medicación analgésica posquirúrgica. El número promedio de analgésicos recetados fue 2,11+0,86. Según covariables se encontró que se recetó un mayor número de analgésicos en los varones (2,18+0,92), en los niños de 7 a 11 años de edad (2,36+0,82); y cuando se realizó exodoncia de diente supernumerario (2,56+0,64). El Ketorolaco fue el analgésico mas recetado en varones (34,9%), en los niños de 7 a 11 años (38,4%) y en exodoncia de dientes retenidos (42,1%). El Paracetamol fue el analgésico más recetado enmujeres (35,1%), en los demás grupos de edad (75%, 80% y 50% en niños de 1 a 3, 4 a 6 y 12 años a mas) y en frenectomia lingual (83,3%). Finalmente se encontró que el ketorolaco y el naproxeno sódico fueron más frecuentemente recetados en exodoncia de diente supernumerarios(34,8% en ambos casos).
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Ruiz-Sánchez, Esaú, Martín Canul-Díaz, Jesse Pacheco-Aguirre, Alfonzo Pérez-Gutiérrez, Arturo Reyes-Ramírez, and Horacio S. Ballina-Gómez. "Efecto de tratamientos pre germinativos e inoculación microbiana en cacahuate (Arachis hypogaea L.)." Revista Mexicana de Ciencias Agrícolas 6, no. 6 (November 24, 2017): 1177. http://dx.doi.org/10.29312/remexca.v6i6.565.

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El cultivo de cacahuate (Arachis hypogaea L.), ampliamente utilizado por los agricultores por su rentabilidad y mejoramiento de las propiedades físicas y químicas edáficas, presenta una prolongada latencia de semillas, que va hasta seis meses. En otras especies vegetales la latencia de semillas se ha tratado con inductores de germinación como el ácido giberélico (AG3), el ácido indolacético y naproxeno (NPX). Otro problema técnico en el cultivo de cacahuate es el crecimiento lento de las primeras etapas de las plantas. Lo anterior podría incrementar con el uso de cepas bacterianas promotoras de crecimiento. El objetivo del presente trabajo fue evaluar el efecto delAG3 y NPX como inductores de germinación, y cepas de Bacillus spp. como promotoras de crecimiento vegetal. En la germinación se usaron dos concentraciones y dos tiempos de inmersión en AG3 y NPX, mientras que para mejorar crecimiento se usaron tres cepas de Bacillus spp. (CBTC1, CBCC57 y CBRF12) como inoculantes. La germinación incrementó con el tratamiento de 10 mg mL-1 deAG3; en tanto, la tasa relativa de crecimiento en altura de las plantas aumentó significativamentealos15díasdespuésdelasiembra,cuando seinocularonconlacepaCBRF12deBacillusspp.Asimismo, seencontróunmayorcrecimientosignificativodelabiomasa seca de la raíz a los 30 días luego de la siembra, con la cepa CBTC1. En conclusión, el porcentaje de germinación de A. hypogaeae incrementó con la adición de AG3. Por su parte, el crecimiento de la planta aumentó, aunque ligeramente, sí de forma significativa y sólo en algunas variables, por la inoculación de las cepas de Bacillus spp. Los resultados del presente estudio muestran la capacidad del AG para romper la latencia de semillas de cacahuate; así como las ventajas de usar bacterias promotoras de crecimiento, en el incremento de la altura y la biomasa de raíces de esta especie vegetal. Esto podría ser de gran ayuda en la producción de cacahuate, al disminuir el tiempo de latencia y acelerar el crecimiento.
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Lizán, Luis, and Silvia Paz. "Sumatriptán y naproxeno combinados en dosis fijas en un solo comprimido aportan mayores beneficios clínicos en el tratamiento agudo de la migraña que la terapia aislada con ambos fármacos." FMC - Formación Médica Continuada en Atención Primaria 14, no. 7 (August 2007): 433. http://dx.doi.org/10.1016/s1134-2072(07)71870-4.

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25

&NA;. "Naproxen see Tolmetin/naproxen." Reactions Weekly &NA;, no. 303 (June 1990): 8. http://dx.doi.org/10.2165/00128415-199003030-00032.

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&NA;. "Naproxen see Amoxicillin/naproxen." Reactions Weekly &NA;, no. 358 (July 1991): 11. http://dx.doi.org/10.2165/00128415-199103580-00057.

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27

Devuni, Vageeshwari. "Naproxen Induced Psoriasis: A Case Report." International Journal of Trend in Scientific Research and Development Volume-3, Issue-4 (June 30, 2019): 1133–35. http://dx.doi.org/10.31142/ijtsrd24004.

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28

Han, M. İhsan, and Ş. Güniz Küçükgüzel. "Anticancer and Antimicrobial Activities of Naproxen and Naproxen Derivatives." Mini-Reviews in Medicinal Chemistry 20, no. 13 (August 20, 2020): 1300–1310. http://dx.doi.org/10.2174/1389557520666200505124922.

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This review explains the effects of naproxen and the naproxen moiety in important biological activities. Naproxen, 2-(6-methoxynaphthalen-2-yl)propionic acid, is one of the most utilized propionic acid derivatives to the cure of many injuries or pains. Naproxen is a non-steroidal antiinflammatory drug (NSAID), which is generally used among the NSAIDs. Even though it has gastrointestinal side effects, naproxen has been safely used for many years because of the good cardiovascular sight. In the past years, except for anti-inflammatory effects, other pharmacological activities of naproxen, especially anticancer and antimicrobial activities, gain the attention of researchers. Naproxen shows its activity by inhibiting the COX-2 enzyme. There is significant interest in the possibility that COX-2 inhibitors might retard or prevent the development of various cancer types, which is often characterized by COX-2 expression. The activities of both naproxen and new molecules derived from naproxen were frequently investigated.
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Akyazi, Hikmet, Davut Baltaci, Sevdegul Mungan, and Ismail Hamdi Kara. "Naproxen-induced fixed drug eruption: A case report." Human & Experimental Toxicology 30, no. 11 (February 28, 2011): 1872–74. http://dx.doi.org/10.1177/0960327111400105.

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Naproxen is a non-steroidal anti-inflammatory drug (NSAID) widely used for symptomatic relief of arthritis and other painful disorders, such as dysmenorrheal. Pruritus is the most common side effect of naproxen. Fixed drug eruption (FDE) due to naproxen is a rarely reported side-effect. No previous report has declared cross-reactivity between naproxen and other propionic acid derivatives. A 28-year-old man, presented with edematous and erythematous patchy lesion along with pruritus and inflammation on lip, have been suffering since 3 hours. It started after taking naproxen 550 mg for headache. On detailed inquiry, he defined similar symptom which recurred after whenever he took naproxen. Based on clinical and histopathological findings, it is evaluated as naproxen-induced FDE. We have tested cross-reactivity between naproxen and other propionic acid derivatives, and then we obtained negative result for oral provocation test with flurbiprofen. Here, we present a case of naproxen-induced FDE of 28-year-old man, by overviewing literatures.
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30

Dharmalingam, Senthil Rajan, Kumarappan Chidambaram, Srinivasan Ramamurthy, and Shamala Nadaraju. "Effects of nanosuspension and inclusion complex techniques on the in vitro protease inhibitory activity of naproxen." Brazilian Journal of Pharmaceutical Sciences 50, no. 1 (March 2014): 165–71. http://dx.doi.org/10.1590/s1984-82502011000100017.

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This study investigated the effects of nanosuspension and inclusion complex techniques on in vitro trypsin inhibitory activity of naproxen—a member of the propionic acid derivatives, which are a group of antipyretic, analgesic, and non-steroidal anti-inflammatory drugs. Nanosuspension and inclusion complex techniques were used to increase the solubility and anti-inflammatory efficacy of naproxen. The evaporative precipitation into aqueous solution (EPAS) technique and the kneading methods were used to prepare the nanosuspension and inclusion complex of naproxen, respectively. We also used an in vitro protease inhibitory assay to investigate the anti-inflammatory effect of modified naproxen formulations. Physiochemical properties of modified naproxen formulations were analyzed using UV, IR spectra, and solubility studies. Beta-cyclodextrin inclusion complex of naproxen was found to have a lower percentage of antitryptic activity than a pure nanosuspension of naproxen did. In conclusion, nanosuspension of naproxen has a greater anti-inflammatory effect than the other two tested formulations. This is because the nanosuspension formulation reduces the particle size of naproxen. Based on these results, the antitryptic activity of naproxen nanosuspension was noteworthy; therefore, this formulation can be used for the management of inflammatory disorders.
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Hurley, Robert W., Debika Chatterjea, Meihua Rose Feng, Charles P. Taylor, and Donna L. Hammond. "Gabapentin and Pregabalin Can Interact Synergistically with Naproxen to Produce Antihyperalgesia." Anesthesiology 97, no. 5 (November 1, 2002): 1263–73. http://dx.doi.org/10.1097/00000542-200211000-00033.

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Background Gabapentin and pregabalin are anticonvulsants with antihyperalgesic effects in animal models of neuropathic and inflammatory nociception. This study characterized the manner in which gabapentin or pregabalin interacts with naproxen to suppress thermal hyperalgesia and inflammation in the carrageenan model of peripheral inflammation. Methods Gabapentin, pregabalin, naproxen, or a fixed-dose ratio of gabapentin + naproxen or pregabalin + naproxen was administered orally to rats after the induction of inflammation by intraplantar injection of lambda-carrageenan in one hind paw. Nociceptive thresholds were determined by the radiant heat paw-withdrawal test. Paw edema was measured by plethysmometry. Drug plasma concentrations were determined by a liquid chromatography-mass spectroscopy-mass spectroscopy method. Results Gabapentin, pregabalin, and naproxen alone reversed thermal hyperalgesia with ED50 values of 19.2, 6.0, and 0.5 mg/kg, respectively. Mixtures of gabapentin + naproxen in fixed-dose ratios of 50:1, 10:1, or 1:1 interacted synergistically to reverse carrageenan-induced thermal hyperalgesia. However, 1:50 gabapentin + naproxen produced only additive effects. No combination of gabapentin + naproxen decreased paw edema in a manner greater than additive. Plasma concentrations of gabapentin and naproxen were unaltered by the addition of the other drug. The mixture of 10:1 of pregabalin + naproxen interacted synergistically to reverse thermal hyperalgesia on the inflamed hind paw, whereas mixtures of 1:1 or 1:10 produced additive effects. Conclusions These data suggest that gabapentin + naproxen and pregabalin + naproxen can interact synergistically or additively to reverse thermal hyperalgesia associated with peripheral inflammation. Therefore, the use of gabapentin or pregabalin in low-dose combinations with naproxen may afford therapeutic advantages for clinical treatment of persistent inflammatory pain.
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Blackler, Rory W., Giada De Palma, Anna Manko, Gabriela J. Da Silva, Kyle L. Flannigan, Premysl Bercik, Michael G. Surette, Andre G. Buret, and John L. Wallace. "Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID." American Journal of Physiology-Gastrointestinal and Liver Physiology 308, no. 12 (June 15, 2015): G994—G1003. http://dx.doi.org/10.1152/ajpgi.00066.2015.

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The small intestine is a significant site of ulceration and bleeding induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The pathogenesis is poorly understood. The present study explored the roles of bile, bacteria, and enterohepatic circulation to NSAID enteropathy, using both a conventional NSAID (naproxen) and a gastrointestinal-safe naproxen derivative (ATB-346), as well as proton pump inhibitors (PPIs). Rats were treated orally with naproxen or equimolar doses of ATB-346 over a 5-day period, with or without PPI administration, and intestinal damage was quantified. The cytotoxicity of bile from the rats was evaluated in vitro. Biliary excretion of naproxen and ATB-346 was determined. The impact of the NSAIDs and of PPIs on the composition of the intestinal microbiota was examined by deep sequencing of 16s rRNA. Naproxen caused significant intestinal damage and inflammation, whereas ATB-346 did not. Naproxen, but not ATB-346, dose dependently increased the cytotoxicity of bile, and it was further increased by PPI coadministration. Whereas biliary excretion of naproxen was significant in naproxen-treated rats, it was greatly reduced in rats treated with ATB-346. The enteric microbiota of naproxen-treated rats was distinct from that in vehicle- or ATB-346-treated rats, and PPI administration caused significant intestinal dysbiosis. The increase in cytotoxicity of bile induced by naproxen and PPIs may contribute significantly to intestinal ulceration and bleeding. Some of these effects may occur secondary to significant changes in the jejunal microbiota induced by both naproxen and PPIs.
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HAAS, Marijke, Frits MOOLENAAR, Dirk K. F. MEIJER, Paul E. DE JONG, and Dick DE ZEEUW. "Renal targeting of a non-steroidal anti-inflammatory drug: effects on renal prostaglandin synthesis in the rat." Clinical Science 95, no. 5 (November 1, 1998): 603–9. http://dx.doi.org/10.1042/cs0950603.

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1.Renal specific targeting of the non-steroidal anti-inflammatory drug naproxen was obtained by coupling to the low-molecular-mass protein lysozyme. A previous study showed that conjugation to lysozyme resulted in a 70-fold increase of naproxen accumulation in the kidney with a subsequent renal release of the active metabolite naproxen–lysine. 2.In the present study we questioned whether naproxen–lysozyme is active in the rat kidney, inhibiting the urinary excretion of prostaglandin E2 and renal sodium and water excretion in salt-restricted baseline conditions as well as during frusemide treatment. 3.A high dose of free naproxen (10 ;mg·day-1·kg-1) did not affect prostaglandin E2 excretion in baseline conditions (naproxen, 11±1 ;ng/8 ;h; vehicle, 13±4 ;ng/8 ;h), whereas sodium and water excretion were, respectively, 3.0 and 1.6 times lower in the naproxen group (P< 0.05). Naproxen completely prevented the frusemide-induced increase (3-fold) in prostaglandin E2 excretion (naproxen 6.6±1.1 ;ng/8 ;h, vehicle 40±12 ;ng/8 ;h, P< 0.005). Frusemide-stimulated natriuresis and diuresis were, respectively, 1.6 (P< 0.05) and 1.8 times (P< 0.005) lower in the naproxen group. 4.A dose of 2 ;mg·day-1·kg-1 lysozyme-conjugated naproxen did not affect prostaglandin E2 excretion in baseline conditions (conjugate, 18±2 ;ng/8 ;h; vehicle, 24±5 ;ng/8 ;h). The conjugate also had no effect on sodium and water excretion. However, the naproxen conjugate completely prevented the frusemide-induced increase (2-fold) in prostaglandin E2 excretion (conjugate, 16±3 ;ng/8 ;h; vehicle, 48±13 ;ng/8 ;h, P< 0.05). Surprisingly, frusemide-induced natriuresis and diuresis were not affected by the conjugate. 5.In conclusion, a renal specific delivery of the non-steroidal anti-inflammatory drug naproxen using lysozyme results in an inhibitory effect on renal prostaglandin E2 synthesis but does not affect the excretion of sodium and water, in contrast to free naproxen.
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Zhou, Jun, Zhiyuan Bao, Panpan Wu, and Chao Chen. "Preparation and Synthetic Application of Naproxen-Containing Diaryliodonium Salts." Molecules 26, no. 11 (May 28, 2021): 3240. http://dx.doi.org/10.3390/molecules26113240.

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The synthesis of naproxen-containing diaryliodonium salts has been realized from naproxen methyl ester and ArI(OH)OTs activated by trimethylsilyl trifluoromethanesulfonate (TMSOTf) in a solvent mixture comprising dichloromethane and 2,2,2-trifluoroethanol (TFE). Those iodonium salts have been successfully used in the functionalization of an aromatic ring of naproxen methyl ester, including fluorination, iodination, alkynylation, arylation, thiophenolation, and amination and esterification reactions. Moreover, further hydrolysis of the obtained 5-iodo-naproxen methyl ester afforded 5-iodo-naproxen.
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35

Dzionek, Anna, Danuta Wojcieszyńska, Katarzyna Hupert-Kocurek, Małgorzata Adamczyk-Habrajska, and Urszula Guzik. "Immobilization of Planococcus sp. S5 Strain on the Loofah Sponge and Its Application in Naproxen Removal." Catalysts 8, no. 5 (April 26, 2018): 176. http://dx.doi.org/10.3390/catal8050176.

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Planococcus sp. S5, a Gram-positive bacterium isolated from the activated sludge is known to degrade naproxen in the presence of an additional carbon source. Due to the possible toxicity of naproxen and intermediates of its degradation, the whole cells of S5 strain were immobilized onto loofah sponge. The immobilized cells degraded 6, 9, 12 or 15 mg/L of naproxen faster than the free cells. Planococcus sp. cells immobilized onto the loofah sponge were able to degrade naproxen efficiently for 55 days without significant damage and disintegration of the carrier. Analysis of the activity of enzymes involved in naproxen degradation showed that stabilization of S5 cells in exopolysaccharide (EPS) resulted in a significant increase of their activity. Changes in the structure of biofilm formed on the loofah sponge cubes during degradation of naproxen were observed. Developed biocatalyst system showed high resistance to naproxen and its intermediates and degraded higher concentrations of the drug in comparison to the free cells.
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Ilic-Stojanovic, Snezana, Vesna Nikolic, Ljubisa Nikolic, Aleksandar Zdravkovic, Agnes Kapor, Mirjana Popsavin, and Slobodan Petrovic. "The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin." Chemical Industry 69, no. 4 (2015): 361–70. http://dx.doi.org/10.2298/hemind131128050i.

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The aim of this work was the preparation of the inclusion complex of naproxen with 2-hydroxypropyl-?-cyclodextrin (HP-?-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-?-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, 1H NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen: 2-hydroxypropyl-?-cyclodextrin was photostable for a period of 30 days.
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Chang, J. C., and H. M. Gross. "Neoplastic fever responds to the treatment of an adequate dose of naproxen." Journal of Clinical Oncology 3, no. 4 (April 1985): 552–58. http://dx.doi.org/10.1200/jco.1985.3.4.552.

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Twenty-one patients with neoplastic fever due to malignancy were treated with naproxen. A prompt and complete lysis of fever was obtained in 20 patients within 12 hours when an adequate dose of naproxen was given, and a sustained normal temperature was maintained in all responding patients while receiving naproxen except for one in whom a low grade fever recurred. Lysis of fever usually was followed by excessive sweating and subjective symptomatic improvement. However, when naproxen was discontinued in ten patients, febrile state to the pretreatment level recurred in seven patients within three days. This observation suggests naproxen has a definite and effective antipyretic activity against neoplastic fever although it may recur as the drug is discontinued. Naproxen may be a useful adjunctive agent in patients with neoplastic fever for a short-term symptomatic relief.
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38

Silberstein, Stephen, Susan A. McDonald, Jerome Goldstein, Sheena Aurora, Shelly E. Lener, Jonathan White, Michael C. Runken, Jane Saiers, Frederick Derosier, and Richard B. Lipton. "Sumatriptan/naproxen sodium for the acute treatment of probable migraine without aura: A randomized study." Cephalalgia 34, no. 4 (October 9, 2013): 268–79. http://dx.doi.org/10.1177/0333102413508242.

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Objective Probable migraine is a common, disabling migraine subtype fulfilling all but one of the diagnostic criteria for migraine. This study was conducted to evaluate the efficacy and tolerability of sumatriptan/naproxen sodium for the acute treatment of probable migraine without aura. Methods Patients treated a headache of probable migraine without aura when pain was moderate or severe with sumatriptan/naproxen sodium ( n = 222 intent-to-treat (ITT)) or placebo ( n = 221 ITT/complete case analysis a ) in this randomized, double-blind, parallel-group study. Results Sumatriptan/naproxen sodium was more effective than placebo with respect to the co-primary efficacy endpoints two-hour pain-free response (29% sumatriptan/naproxen sodium vs 11% placebo, p < 0.001) and two- to 24-hour sustained pain-free response (24% sumatriptan/naproxen sodium vs 9% placebo, p < 0.001). Sumatriptan/naproxen sodium was significantly more effective than placebo with respect to the secondary efficacy endpoints of pain-free response four hours postdose ( p < 0.001), pain-free response maintained one to two hours postdose ( p = 0.034) and two to four hours postdose ( p < 0.001), headache relief four hours postdose ( p < 0.001), headache relief maintained two to four hours postdose ( p = 0.015), sustained headache relief two through 24 hours postdose ( p = 0.002), and rescue medication use ( p < 0.001); but not productivity scores. The most common adverse events were dizziness (4% sumatriptan/naproxen sodium,<1% placebo), dry mouth (2% sumatriptan/naproxen sodium, <1% placebo), and nausea (2% sumatriptan/naproxen sodium, <1% placebo). Conclusion Sumatriptan/naproxen sodium is effective in the acute treatment of probable migraine as demonstrated by higher rates of freedom from pain and restoration of function.
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Cheng, H.-H., C.-T. Chou, T.-K. Sun, W.-Z. Liang, J.-S. Cheng, H.-T. Chang, H.-W. Tseng, et al. "Naproxen-induced Ca2+ movement and death in MDCK canine renal tubular cells." Human & Experimental Toxicology 34, no. 11 (January 30, 2015): 1096–105. http://dx.doi.org/10.1177/0960327115569810.

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Naproxen is an anti-inflammatory drug that affects cellular calcium ion (Ca2+) homeostasis and viability in different cells. This study explored the effect of naproxen on [Ca2+]i and viability in Madin-Darby canine kidney cells (MDCK) canine renal tubular cells. At concentrations between 50 μM and 300 μM, naproxen induced [Ca2+]i rises in a concentration-dependent manner. This Ca2+ signal was reduced partly when extracellular Ca2+ was removed. The Ca2+ signal was inhibited by a Ca2+ channel blocker nifedipine but not by store-operated Ca2+ channel inhibitors (econazole and SKF96365), a protein kinase C (PKC) activator phorbol 12-myristate 13-acetate, and a PKC inhibitor GF109203X. In Ca2+-free medium, pretreatment with 2,5-di-tert-butylhydroquinone or thapsigargin, an inhibitor of endoplasmic reticulum Ca2+ pumps, partly inhibited naproxen-induced Ca2+ signal. Inhibition of phospholipase C with U73122 did not alter naproxen-evoked [Ca2+]i rises. At concentrations between 15 μM and 30 μM, naproxen killed cells in a concentration-dependent manner, which was not reversed by prechelating cytosolic Ca2+ with the acetoxymethyl ester of 1,2-bis(2-aminophenoxy)ethane- N, N, N′, N′-tetraacetic acid acetoxymethyl. Annexin V/propidium iodide staining data suggest that naproxen induced apoptosis. Together, in MDCK renal tubular cells, naproxen induced [Ca2+]i rises by inducing Ca2+ release from multiple stores that included the endoplasmic reticulum and Ca2+ entry via nifedipine-sensitive Ca2+ channels. Naproxen induced cell death that involved apoptosis.
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Wang, Qian-Long, Jing Xie, Jian Liang, Geng-Ting Dong, Li-Sheng Ding, Pei Luo, and Lin-Sen Qing. "Competitive Protein Binding Assay of Naproxen by Human Serum Albumin Functionalized Silicon Dioxide Nanoparticles." Molecules 24, no. 14 (July 17, 2019): 2593. http://dx.doi.org/10.3390/molecules24142593.

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We have developed a new competitive protein binding assay (CPBA) based on human serum albumin functionalized silicon dioxide nanoparticles (nano-SiO2-HSA) that can be used for naproxen determination in urine. Compared with a conventional multi-well reaction plate, nano-SiO2 with a high surface-area-to-volume ratio could be introduced as a stationary phase, markedly improving the analytical performance. Nano-SiO2-HSA and horseradish peroxidase-labeled-naproxen (HRP-naproxen) were prepared for the present CPBA method. In this study, a direct competitive binding to nano-SiO2-HSAwas performed between the free naproxen in the sample and HRP-naproxen. Thus, the catalytic color reactions were investigated on an HRP/3,3′5,5′-tetramethylbenzidine (TMB)/H2O2 system by the HRP-naproxen/nano-SiO2-HSA composite for quantitative measurement via an ultraviolet spectrophotometer. A series of validation experiments indicated that our proposed methods can be applied satisfactorily to the determination of naproxen in urine samples. As a proof of principle, the newly developed nano-CPBA method for the quantification of naproxen in urine can be expected to have the advantages of low costs, fast speed, high accuracy, and relatively simple instrument requirements. Our method could be capable of expanding the analytical applications of nanomaterials and of determining other small-molecule compounds from various biological samples.
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Jiang, Xu Hong, and Zhan Mei Liu. "Uiformly-Sized, Molecularly Imprinted Polymers for Naproxen by Precipitation Polymerization." Advanced Materials Research 399-401 (November 2011): 713–17. http://dx.doi.org/10.4028/www.scientific.net/amr.399-401.713.

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Uniformly-sized, molecularly imprinted polymers (MIPs) for (D)-naproxen have been prepared by a precipitation polymerization method using methacrylic acid (MAA) as a functional monomer and divinylbenzene (DVB) as a cross-linker in acetonitrile or a mixture of toluene and acetonitrile(1:3). The (D)-naproxen-imprinted MAA-co-DVB polymers were monodispersed microspheres with size in the range of 1.5 to 3.6µm. Enantioseparation of naproxen was attained using the (D)-naproxen-imprinted MAA-co-DVB polymer microspheres. When Ethylene glycol dimethacrylate(EGDMA) was used as a cross-linker, the MAA-co -EGDMA polymers were sub-microspheres with the average size of 350nm and showed very low affinity for the template (D)-naproxen . The (D)-naproxen-imprinted MAA-co-DVB polymer microspheres prepared in the mixture of toluene showed the highest molecular recognition ability and with the biggest size of 3.6µm.
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Lubet, Ronald A., Amit Kumar, Jennifer T. Fox, Ming You, Altaf Mohammed, M. Margaret Juliana, and Clinton J. Grubbs. "Efficacy of EGFR Inhibitors and NSAIDs Against Basal Bladder Cancers in a Rat Model: Daily vs. Weekly Dosing, Combining EGFR Inhibitors with Naproxen, and Effects on RNA Expression." Bladder Cancer 7, no. 3 (August 31, 2021): 335–45. http://dx.doi.org/10.3233/blc-200423.

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BACKGROUND: There are few effective treatments specifically aimed at basal bladder cancer. OBJECTIVE: Female F344 rats administered N-butyl-N-(4-hydroxybutyl)-nitrosamine (OH-BBN) develop large invasive bladder cancers. We determined the efficacy of daily vs weekly dosing of EGFR inhibitors, determined the efficacy of naproxen combined with an EGFR inhibitor, and performed RNA analysis of bladder tumors treated for 5 days with EGFR inhibitors or NO-naproxen to identify pharmacodynamic biomarkers. METHODS: Erlotinib (6 mg/Kg BW daily or 21 or 42 mg/Kg BW weekly), lapatinib (25 or 75 mg/Kg BW daily or 263 or 525 mg/Kg BW weekly) and/or naproxen (30 mg/Kg BW daily) were administered to OH-BBN-treated rats beginning 2–12 weeks post OH-BBN. Rats were sacrificed 28 weeks after the final OH-BBN treatment to determine the effects of the EGFR inhibitors + naproxen on bladder weights and tumor development. In a separate study, rats were treated with OH-BBN. When palpable tumors developed, rats were treated with erlotinib, lapatinib, gefitinib, or the NSAID NO-naproxen for 5 days. RNA analysis was performed on the tumors. RESULTS: Daily or weekly dosing of erlotinib or lapatinib and daily dosing of naproxen reduced large tumor formation up to 70%, while combining daily lapatinib and naproxen reduced tumors 100%. RNA Analysis: All EGFR inhibitors strongly reduced cell proliferation and chromosome replication pathways, while NO-naproxen altered the G protein receptor, oxygen homeostasis and immune function pathways. CONCLUSIONS: While daily and weekly dosing with EGFR inhibitors and naproxen were effective, combining lapatinib and naproxen yielded no tumors. This might encourage its clinical use in an adjuvant setting with superficial basal tumors, and perhaps even in a more advanced setting. Furthermore, RNA analysis identified specific pathways that might be potential pharmacodynamic biomarkers in clinical trials.
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Felis, E., D. Marciocha, J. Surmacz-Gorska, and K. Miksch. "Photochemical degradation of naproxen in the aquatic environment." Water Science and Technology 55, no. 12 (June 1, 2007): 281–86. http://dx.doi.org/10.2166/wst.2007.417.

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Naproxen belongs to the group of non-steroidal anti-inflammatory drugs. It is often used to treat pain of rheumatic and non-rheumatic diseases. The photochemical experiments of naproxen degradation were performed in the wastewater effluents from wastewater treatment plant (WWTP) Kloten/Switzerland at its real concentrations (without standard addition) and in drinking water containing naproxen standard, adjusted to pH = 7 and pH = 6. All performed experiments showed that within 5 min of photochemical oxidation, the disappearance of naproxen exceeded 90%. The first-order rate constants of naproxen degradation were determined. The maximal value of rate constant was observed by UV/H2O2 process in water samples at pH = 6 (k=0.997 min−1).
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&NA;. "Naproxen." Reactions Weekly &NA;, no. 770 (September 1999): 8. http://dx.doi.org/10.2165/00128415-199907700-00028.

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&NA;. "Naproxen." Reactions Weekly &NA;, no. 1261 (July 2009): 22. http://dx.doi.org/10.2165/00128415-200912610-00074.

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&NA;. "Naproxen." Reactions Weekly &NA;, no. 1314 (August 2010): 31. http://dx.doi.org/10.2165/00128415-201013140-00098.

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&NA;. "Naproxen." Reactions Weekly &NA;, no. 444 (March 1993): 9. http://dx.doi.org/10.2165/00128415-199304440-00038.

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&NA;. "Naproxen." Reactions Weekly &NA;, no. 450 (May 1993): 14. http://dx.doi.org/10.2165/00128415-199304500-00062.

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&NA;. "Naproxen." Reactions Weekly &NA;, no. 464 (August 1993): 10. http://dx.doi.org/10.2165/00128415-199304640-00052.

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&NA;. "Naproxen." Reactions Weekly &NA;, no. 427 (November 1992): 10. http://dx.doi.org/10.2165/00128415-199204270-00037.

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