Dissertations / Theses on the topic 'Nanoparticle'
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Rousseau, Youri. "Hybridation des technologies de jets de nanoparticules et de PVD pour la réalisation d’architectures nanocomposites fonctionnelles." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS347.
Full textThe nanocomposite films are coatings of nanoparticles embedded in a solid matrix of a different material. The advantage of these materials is their ability to exploit the unique properties of nano-objects while benefiting of the mechanical and chemical resistance properties of the matrix. These composites have very promising properties for many applications such as photovoltaics and photocatalysis. Several existing synthetic methods can produce nanocomposite materials by physical or chemical methods (co-sputtering, sol-gel, ...). However, none is flexible enough to consider the synthesis of a wide range of nanocomposites by the same method. This is an obstacle to the development on an industrial scale of this type of material. The first objective of the thesis is to develop an original synthesis process of nanocomposite films. This method is universal in which it presents no limit in the choice of nanoparticles and matrix. The developed method combines vacuum nanoparticle jets formed by an aerodynamic lens with a magnetron sputtering device for depositing the matrix. The nanoparticle jets can be coupled with any source of nanoparticles. Nanoparticles may be synthesized in situ in the gas phase or beforehand solution synthesis. A wide variety of nanoparticles can be used. Magnetron sputtering also enables to have a very wide range of materials for the matrix (metal, ceramic, polymer). During this thesis, two types of nanoparticles sources were used. The first one is a laser pyrolysis reactor and the second is an aerosol generator. The laser pyrolysis reactor enables in-situ gas phase synthesis of the nanoparticles while the aerosol generator use a suspension of previously synthesized nanoparticles. To test the robustness of the co-deposition process, two types of nanocomposite materials have been developed. The first material is composed of 35 nm spherical gold nanoparticles, chemically synthesized, in a silica matrix. The goal here is to benefit from the unique optical properties of gold nanoparticles in a film mechanically and chemically resistant. The characterizations carried out on these materials have optimized the gold nanoparticle concentration in the films to keep the mechanical and chemical properties compatible with applications while maintaining satisfactory optical properties. The second type of materials studied is composed of semiconductor nanoparticles in situ synthesized by laser pyrolysis and a metal matrix. The synthesis of this material demonstrates the flexibility of the co-deposition method to synthesize a wide variety of nanocomposite films. Finally, the design of an industrial pilot was undertaken. The final goal is to have a pilot-scale setup that meets industry requirements in the context of a technology transfer
Tang, Lu. "Nanoparticules mimes des propriétés biologiques des GAGs : vers un inhibiteur sélectif de CXCL12." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS072.
Full textHéparan Sulfate (HS) is a linear polysaccharide that modulates the biological activities of numerous proteins. In order to elucidate the interaction between HS and proteins, the synthesis of HS is an invaluable tool, but the synthesis is sometimes difficult. Our group has demonstrated that the combinatorial mixtures obtained by self-assembly of different combinations of disaccharide derivatives (lactose and persulfated lactose) on gold plan surfaces could recognize specifically some HS binding proteins, such as the isoforms of the chemokine CXCL12 or IFNγ. Because of the toxicity of gold nanoparticles, we have also adapted this method to lipid nanoparticles. Using the conditions that have already improved during the synthesis of lactose and persulfated lactose derivatives, we have synthesized two other disaccharide derivatives, which were closer to the real structure of HS. These new derivatives were used to prepare the gold and lipid nanoparticles at the aim of comparing the properties with lactose and persulfated lactose. The tests of affinities with different proteins are in progress
Smith, Beverly. "Investigating Thermal Transformations of Ligand-Stabilized Gold Nanoparticles: Influence of the Structural Attributes of the Nanoparticle and Its Environment on Thermal Stability." Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/19259.
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McQuillan, Jonathan. "Bacterial-nanoparticle interactions." Thesis, University of Exeter, 2010. http://hdl.handle.net/10036/3101.
Full textKang, Minkyung. "Single nanoparticle electrochemistry." Thesis, University of Warwick, 2017. http://wrap.warwick.ac.uk/99424/.
Full textPranami, Gaurav. "Understanding nanoparticle aggregation." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3369880.
Full textHaghighat, Manesh Mohamad Javad Haghighat. "Effects of the Nanoparticle Protein Corona on Nanoparticle-Cell Membrane Interactions." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1597967288027448.
Full textLouie, Stacey Marie. "Characterization and Modeling of Macromolecules on Nanoparticles and Their Effects on Nanoparticle Aggregation." Research Showcase @ CMU, 2014. http://repository.cmu.edu/dissertations/396.
Full textD'britto, V. "Synthesis of metal nanoparticles and polymer/metal nanoparticle composites: investigation towards biological applications." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2010. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/3716.
Full textMarchioni, Marianne. "Ecoconception de nouveaux agents biocides à base de nanoparticules d'argent à enrobage bio-inspiré." Thesis, Université Grenoble Alpes (ComUE), 2018. http://www.theses.fr/2018GREAV046/document.
Full textSilver nanoparticles are increasingly used in everyday consumer goods as well as in medical devices for their biocidal activity, which is due to the release of Ag(I) ions over time. The hindsight on these nano-objects and, in particular, on their safety is still not sufficient and studies on their transformation and their impact in vivo is currently an intense research field. Indeed, the fate in the body of macro- and micro-materials studied classically is not the same as for nanomaterials. The case of the silver nanoparticles illustrates this problem: the soluble silver injected intravenously is eliminated faster than the same amount of silver injected in nanoparticular form. Moreover, the concentration of silver found in the bloodstream and organs is ten times higher when silver nanoparticles are injected rather than ingested. The development of silver nanoparticle-containing implanted devices, that get in direct contact with the body, must thus take into account the related risks. A Safer-by-design approach could be a way to solve this issue.One of the main components of Safer-by-design development is the functionalization of nano-objects. The affinity of the thiolates for Ag(I) ions is very high, which would make thiolated ligands a good tool for silver nanoparticle functionalization. However, it is known that the thiolated molecules lead to different behaviors, ranging from the dissolution of silver nanoparticles into Ag(I) ions to the simple passivation of the surface of the nanoparticles, which leads to the loss of their biocidal activity.The Ecodesign of New Biocidal Agents based on Silver Nanoparticles and Bio-inspired Coating is therefore at the interface of several research areas and its main objective was to lay the conceptual foundations for the development of a Safer-by-design biocidal agent based on the interaction between silver nanoparticles and thiolated molecules.The development of this project required to study the reactivity of various biological or bio-inspired thiolated molecules with silver nanoparticles. First of all, we have highlighted the importance of the architectural pre-organization of biomolecules in the dissolution kinetics, as well as the role of the number of free thiols in the molecule. In the case of molecules inducing the dissolution of the nanoparticles, its kinetics increases with the number of free thiols present on the molecule and with the pre-organization of the metal binding site. In a second time, the main project of this thesis was the development of a proof of concept of a new biocidal agent composed of silver nanoparticles bridged together via a thiolated ligand, which is the chemical mimic of one binding site of a metallothionein. These nanoparticle assemblies were active against bacteria (E. coli) and less toxic than silver nanoparticles on eukaryote cells (HepG2), despite a similar cellular entry. Finally, a screening was performed with polyethylene glycols having two to eight thiols and varying polymer lengths in an attempt to rationalize the differences in the behavior of silver nanoparticles in the presence of the thiolated molecules. This ongoing work leads to various behaviors that will enable to explore novel ways for the development of biocidal based on nanoparticles assemblies mediated by thiol – Ag(I) bonds.Therefore, this overall PhD work allows performing both very fundamental researches concerning the reactivity of thiols with surface silver atoms of the nanoparticles and the development of products with application potential, silver nanoparticle assemblies that are Safer-by-design biocide
Hou, Xue. "Nano-objets photo-activés pour le ciblage cellulaire et l’hyperthermie." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLC011/document.
Full textPlasmonic nanoparticles possessinteresting properties thanks to the localizedsurface plasmon resonance. In addition totheir high photothermal conversion efficiency,the heat release confinement can bemodulated by the type of light source used(pulsed or continuous laser). These propertiesmake the plasmonic nanoparticles a potentialsolution for cancer therapy by hyperthermia.In order to develop such a biomedicalapplication, it is necessary to optimize theabsorption of light energy and the targeting ofnanoparticles on the tumor considered.In this thesis, the influence of the photogeneratedhot electrons on the absorption ofultrashort laser pulses by nanoparticles is firststudied. Then, a work carried out withchemists, biologists and physicians for theapplication of gold nanoparticles irradiated byultrashort laser pulses to cancer therapy isdescribed. Finally, we present a preliminarystudy on the photoluminescence of plasmonicnanoparticles, the origin of which is stillcontroversial, by applying a model accountingfor the non-thermal nature of the hot electrondistribution
Dehankar, Abhilasha Vinod. "Investigation of Inorganic Nanoparticle Spatial Interactions by Development of Novel Nanoparticle Composites." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1565887276935787.
Full textPantidos, Nikolaos. "Biological synthesis of stable copper nanoparticles." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29532.
Full textZhou, Bo. "Synthesis and characterization of crystalline assembly of poly Nisopropylacry-lamide)-co-acrylic acid nanoparticles." Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4671/.
Full textGoren, Michal. "Nanoparticle adsorption onto surfaces." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84250.
Full textThis Thesis is concerned with the interface between surface chemistry and nano-chemistry through templating. Templated growth of polypyrrole (Ppy) on two different surfaces is described. Templating results in Ppy having unique nanomorphologies of wires and dots. A system where Ppy selectively grows on lipid bilayer edges (as per Qi, Proc.-Electrochem. Soc. 1997, 97-5, 173) is described. A general mechanism for Ppy deposition on surfaces is presented. A system where Ppy grows selectively on PS-PVP block copolymer surface micelles is also described. It is demonstrated that a template surface may be modified while templating occurs on it. Finally, the adsorption kinetics of nanoparticles onto self-assembled monolayers (SAMs) is studied in the context of differential surface energies being a driving force for the adsorption. The adsorption kinetics are studied using the Surface Plasmon Resonance (SPR) technique. This study reveals that there is a correlation between the driving force for adsorption and the adsorption kinetics.
Carkner, Andrew. "Green metal nanoparticle synthesis." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22037.
Full textTitre: Production vert de nanoparticules métalliques Les nanoparticules d'argent et de nickel ont de diverses applications en catalyse, matériaux composites et électronique. Cependant la production actuelle utilise soit beaucoup d'énergie soit de composés dangereux ; il sera mieux pour la santé et l'environnement de trouver d'alternatives. Ce projet a examiné le glucose et le formate comme alternatifs au hydrazine pour la synthèse aqueuse des nanoparticules. Quoique les conditions thermodynamiques sont favorables, je n'ai pas pu produire de nanoparticules de nickel sauf avec le hydrazine dans la région pH 4-12 et T ≤ 100oC. Avec le glucose ou le formate, la conversion demeure insignifiant après 8h. Avec le hydrazine, une haute température et pH sont nécessaires pour une réaction rapide. Avec pH 12, 100oC et 20 mM d'acetate de nickel, la conversion est 70% après 30 minutes. Sous pH 10 et 80oC, la conversion est négligeable même après 3 heures.
Stott, Susan J. "Electroanalysis in nanoparticle assemblies." Thesis, Loughborough University, 2007. https://dspace.lboro.ac.uk/2134/12882.
Full textMurray, K. A. "Multiplexed nanoparticle-based immunoassays." Thesis, Nottingham Trent University, 2010. http://irep.ntu.ac.uk/id/eprint/167/.
Full textLi, Wenhui. "Connecting Thermodynamics and Kinetics of Ligand Controlled Colloidal Pd Nanoparticle Synthesis." Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/100595.
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Austin, Lauren Anne. "Exploring some aspects of cancer cell biology with plasmonic nanoparticles." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/54236.
Full textBhave, Radhika. "Nanoparticle-Cell Lipid Membrane Biophysical Interaction and its Role in Developing Tumor Targeted Nanoparticles." Cleveland State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=csu1433170085.
Full textZhao, Pengxiang. "Nanoparticules d’ or : fonctionnalisations et applications en nanomédecine et nanomatériaux." Thesis, Bordeaux 1, 2012. http://www.theses.fr/2012BOR14556/document.
Full textThe thesis concerns functionalizations and applications of gold nanoparticles (AuNPs). In the aspects of functionalization of AuNPs, we concentrated on efficiently functionalized AuNPs by “Click” chemistry. In the aspects of applications, the PEG capped AuNPs was prepared to encapsulate vitamins, which has a potential use in hydrophobic part of human body; the folate functionalized AuNPs was used for docetaxel delivery for cancer therapy; the novel synthesis of triazole stabilized AuNPs used for biosensors; and the citrate capped AuNPs introduced into the silica thin films to check the SERS effect and spin crossover of iron complexes
Min, Yuanyuan. "Controlled synthesis of Ru nanoparticle covalent assemblies and their catalytic application." Thesis, Toulouse, INPT, 2020. http://www.theses.fr/2020INPT0021.
Full textThis research work focuses on the preparation of Ru nanoparticle (NP) covalent assemblies stabilized by different functional molecules, and the study of structure/activity relationships for catalytic hydrogenation reactions. Chapter 1 reviews the metal NP covalent assemblies according to the synthesis strategies and their application in catalysis. Chapter 2 described the preparation of three-dimension (3D) Ru NP covalent assemblies characterized by: i) well-defined nanometricsized Ru NP stabilized by functionalized adamantane, bis-adamantane and diamantane ligands, and ii) a tunable interparticle distance. The coordination chemistry with amine and carboxylic acid ligands towards the Ru NP surface was investigated. In the case of carboxylic acid ligands it was shown that Ru species formed during the NP assembly are able to partially decarbonylate carboxylic acid ligands at room temperature. The mechanism of this reaction was elucidated by DFT. Chapter 3 detailed the use of other molecular building blocks for Ru NP assembly formation. We showed that the use of tricarboxylic-hexyloxy triphenylene ligand leads to the formation of twodimensional (2D) Ru NP assemblies with homogeneous interparticle distance and NP size. Additionally, 3D Ru NP assemblies were prepared with 9, 10-dicarboxylic anthracene and a hexaadduct functionalized C60 fullerene. In Chapter 4 we studied the catalytic performances of the Ru NP networks in various reactions. All these materials constitute an interesting set to investigate the structural and electronic effects in heterogeneous catalysis. In the selective hydrogenation of phenyl acetylene, the assemblies are active, reaching good selectivity towards styrene. Especially, we demonstrated that confinement and electronic effects are occurring and that Ru NP interparticle distance affects the catalyst activity, whereas electronic effects mainly govern the catalyst selectivity. The stability of the Ru NP assembly is finally discussed
Schwarb, Ryan Evan. "Synthesis and Characterization of Reactive Core-Shell Nanoparticles." University of Dayton / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1332256634.
Full textCrew, Elizabeth. "Nanoparticle-based analytical/bioanalytical probes investigation of interactions and reactivities between gold nanoparticles and homocysteine /." Diss., Online access via UMI:, 2005. http://wwwlib.umi.com/dissertations/fullcit/1425749.
Full textNörbel, Lena Verfasser], Andreas [Akademischer Betreuer] Offenhäusser, and Ulrich [Akademischer Betreuer] [Simon. "DNA-capped silver nanoparticles for stochastic nanoparticle impact electrochemistry / Lena Nörbel ; Andreas Offenhäusser, Ulrich Simon." Aachen : Universitätsbibliothek der RWTH Aachen, 2021. http://d-nb.info/1238235360/34.
Full textFanelli, Claudia. "Diffusion processes and nanoparticle growth." Doctoral thesis, Universitat Politècnica de Catalunya, 2020. http://hdl.handle.net/10803/669564.
Full textAnderson, Ingrid E. "All-inorganic nanoparticle solar cells /." Diss., Digital Dissertations Database. Restricted to UC campuses, 2009. http://uclibs.org/PID/11984.
Full textDerfus, Austin Matthew. "Toward multifunctional nanoparticle-based therapeutics." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3254426.
Full textTitle from first page of PDF file (viewed May 3, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 121-135).
Abeylath, Thotaha Wijayahewage Sampath Chrysantha. "Glyconanobiotics : novel carbohydrated nanoparticle polymers." [Tampa, Fla] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0001948.
Full textDerrien, Thomas. "Gold nanoparticle-lipid bilayer interactions." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86727.
Full textL'interaction des nanoparticules d'or avec les bicouches lipidiques est présentée dans ce mémoire. Les facteurs influençant cette interaction ont été explorés en utilisant des bicouches lipidiques synthétiques. L'interaction due à l'incorporation des nanoparticules au sein des bicouches a été étudiée par des techniques d'imagerie. Un test de fuite de fluorophore a été employé afin de déterminer l'influence de la composition et de la structure des ligands protégeant les nanoparticules sur leur incorporation dans les bicouches de lipides. Pour cela, nous avons développer une synthèse de nanoparticules protégées par deux types de ligands. Des expériences in vivo ont été réalises avec des nanoparticules d'or fonctionnalisées avec des peptides ainsi que des fluorophores, mis en contact avec des cellules vivantes de type HeLa. Nous avons constaté que les nanoparticules d'or sont capables de franchir les bicouches lipidiques en utilisant des mécanismes indépendants d'énergie. Nous concluons que la structure et la composition des ligands protégeant les nanoparticules ont une grande influence sur la perturbation qu'elles induisent dans la structure des bicouches lipidiques.
Southern, Paul James David. "Magnetic interactions in nanoparticle systems." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492513.
Full textHogg, Charles R. III. "Pattern Transfer from Nanoparticle Arrays." Research Showcase @ CMU, 2010. http://repository.cmu.edu/dissertations/14.
Full textRidder, Kristin Barbara. "Nanoparticle formulations in HFA propellants." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412545.
Full textVirden, Anne E. "Magnetic studies of nanoparticle systems." Thesis, University of York, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441068.
Full textHu, Zhongliang. "Nanoparticle-assisted enhanced oil recovery." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/19440/.
Full textThomas, L. "Nanoparticle synthesis for magnetic hyperthermia." Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/646236/.
Full textCoglitore, D. "Nanoparticle dynamics in simple fluids." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3007090/.
Full textVenkatasubramanian, Rajiv. "Composite Nanoparticle Materials for Electromagnetics." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1352993374.
Full textAlzahrani, Ahmed Obaid M. "Multi-scale nanoparticle contrast agents." Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/18150.
Full textPromtong, Pawika. "Determinants of silver nanoparticle toxicity." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/determinants-of-silver-nanoparticle-toxicity(5b09211a-35b6-4f8c-8677-a76f652494b3).html.
Full textRong, Guoxin, Hongyun Wang, and Bjӧrn M. Reinhard. "Insights from a nanoparticle minuet." Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-184924.
Full textAlbert, Claire. "Émulsions de Pickering biodégradables stabilisées par des nanoparticules de poly(acide lactique-co-glycolique) : étude physico-chimique et potentialité pharmaceutique." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS491.
Full textIn this thesis work, we formulated stable, biodegradable and biocompatible Pickering emulsions stabilized with nanoparticles (NPs) of poly(lactic-co-glycolic acid) (PLGA). Such emulsions are an alternative, potentially less toxic and irritating, to conventional emulsions stabilized with surfactants. Firstly, a thorough physico-chemical study of these systems was conducted in order to clarify their structures (macroscopic, microscopic and interfacial) as well as their mechanisms and kinetics of stabilization. Studies of the contribution of the polymer stabilizing the NPs and of the characteristics of the PLGA polymer on the properties of the emulsions were also carried out. This enabled a better identification of the physico-chemical key parameters responsible for a good stabilization. Secondly, we focused on the pharmaceutical potential of these emulsions for a topical application. Pharmaceutical active ingredients (API), used for the treatment of psoriasis, were successfully encapsulated in the NPs (cyclosporine A and tacrolimus) and the emulsion droplets (calcitriol). This study is a first step towards the use of these emulsions for the co-encapsulation of two API: one in the NPs and a second in the oil droplets. The co-encapsulation should improve patient compliance and could lead to a synergistic effect between the two API
Jones, Bernard. "Monte Carlo calculations of microscopic dose enhancement for gold nanoparticle-aided radiation therapy." Thesis, Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/34746.
Full textManohar, Nivedh Harshan. "Quantitative imaging of gold nanoparticle distribution for preclinical studies of gold nanoparticle-aided radiation therapy." Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54877.
Full textDeraedt, Christophe. "Nanoréacteurs pour la catalyse en milieux aqueux." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0430/document.
Full textThis thesis concerns the synthesis by “click” CuAAC reactions of newnanomaterials that have various applications, in particular in catalysis. Thesemacromolecules are dendrimers, supported dendrimers and polymers that contain1,2,3-triazole rings and were used in the stabilization of essentially palladiumnanoparticles (PdNPs). These PdNPs are extremely active in the catalysis in greensolvents of C-C coupling, reduction of 4-nitrophenol and selective oxidation ofalcohols. The use of these nanoparticle catalysts at the ppm level shows theirefficiency and their ecological aspect. The integration of biferrocene units in thepolymers allowed expanding their applications to electrochemical sensors, reductantsof metallic ions to nanoparticles, polyelectrolytes, polyelectrochromic, and mixedvalentcomplexes. The impregnation of PdNPs stabilized by dendrimers on magneticsupport led to the increase of the catalyst robustness and recyclability using amagnet
Law, Frédéric. "Effet de la combinaison des nanoparticules de gadolinium et de la radiothérapie sur l'élimination des cellules tumorales." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS138.
Full textThe nanotechnology aims to help in the cancer treatment. Olivier Tillement and his colleagues have demonstrated that the Gadolinium-Based Nanoparticle (GdBN) can improve Magnetic Resonance Imaging (MRI) and increase radiotherapy effects. Pre-clinical studies show that the combination of GdBN with ionizing radiation is associated with tumor regression. However, the molecular and cellular processes involved this biological effect remain to be elucidated. Our results show that the combination of GdBN with IR generates oxidative stress through NADPH oxidase-dependent mechanisms, leads to cellular senescence and induces the cannibalistic activity of irradiated cells. Altogether, these results reveal that the combination of GdBN with IR promotes the killing of irradiated cells through the induction of cellular senescence and cellular cannibalism
Skarbek, Charles. "Synthèse et évaluation pharmacologique d’analogues préactivés de l’ifosfamide : prodrogues et nanoparticules à visée antitumorale." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS247/document.
Full textIfosfamide (IFO) and cyclophosphamide (CPM) are oxazaphosphorines, prodrugs requiring bioactivation to be active. Regarding IFO, its biotransformation leads to a low release of the active hydroxylated compound with associated toxic side effects. Preactivated IFO analogs with saturated or unsaturated C1-C30 chains have been developed to circumvent these toxicities related to the toxicogenic pathway of metabolism. As part of IFO's pharmaco-modulation strategy, the cytotoxic evaluation of these compounds, synthesized by engraftment of poly-isoprenyloxy chains, was carried out in vitro on human cancer cell lines. In vivo study of the lead shows the better pharmacokinetic profile of Geranyloxy-IFO compared to IFO. These analogs were then vectorized as nanosystems, either by self-assembly or by lipidic encapsulation leading to 1st generation nanosystems. They are still under investigation in order to bring specificity by passive or active targeting.Furthermore, CPM is known for having an activity on the immune system at low dose. Due to the structural proximity of IFO and CPM, we fulfilled studies to highlight the effect of IFO on the immune system at low dose in comparison to the immunomodulatory dose of CPM.The combination of these two strategies (preactivation & immunomodulatory effect) could lead to the development of novel derivatives showing an antitumor synergy of the antiproliferative and immunomodulatory effects of these oxazaphosphorines
Fu, Chunkai. "Investigation of the Stability of Nanoparticles under Different Conditions and Rheology of Nanoparticle-Stabilized CO2 Foam." Thesis, University of Louisiana at Lafayette, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=10814705.
Full textA high-pressure CO2 foam was generated with silica nanoparticle dispersion and CO2 for fracturing applications. The effects of different ions and temperature on nanoparticle aggregation were studied. Nanoparticle dispersions were mixed with individual monovalent, divalent ions with varying concentrations, and two synthesized Permian connate water solutions. Samples of nanoparticle dispersions with the presence of NaCl were put into chambers with constant temperature for 14 hours. The peak size of aggregated nanoparticles in each sample was measured. It was found this silica nanoparticle dispersion had a high thermal stability up to 85?. The silica nanoparticle dispersion used in this study maintained a desired stability under an 18% reservoir salinity condition, yet it could be sensitive to high concentrations of Na2SO4 solutions. To investigate foam rheology and stability, high-pressure CO2 foams were generated in a beadpack with different CO2/NP ratios in NaCl solutions. The resulting foam was observed in a sapphire tube. The differential pressure across a capillary tube was recorded to calculate the apparent viscosity of foams. Nanoparticle-stabilized foams could remain stable for days and foam stability decreased with the increasing foam quality. Foam apparent viscosity was found to increase with foam quality and could be 3 times as high as that of the ambient phase. The high stability and fine texture of high-pressure CO2-in-water foams stabilized by silica nanoparticles have broadened the development of foam fracturing, offering a new opportunity for the effective development and stimulation of unconventional reservoirs.
Watson, Venroy George. "Decoration of Graphene Oxide with Silver Nanoparticles and Controlling the Silver Nanoparticle Loading on Graphene Oxide." University of Dayton / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=dayton1396879714.
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