Relevant bibliographies by topics / Nanoparticle treatment

Academic literature on the topic 'Nanoparticle treatment'

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Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Nanoparticle treatment"

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Choudhary, Tripta, Vikas Beniwal, Pooja Nehra, and Deepak Singhwal. "Photocatalytic Treatment of MB Dye Using ZnO Nanoparticles." ECS Transactions 107, no. 1 (April 24, 2022): 16213–21. http://dx.doi.org/10.1149/10701.16213ecst.

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The present study revealed the synthesis of zinc oxide nanoparticles by wet chemical co-precipitation process and were characterized by X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), UV-Vis spectroscopy, and photocatalysis for Methylene Blue (MB) dye degradation. The crystallite size of the ZnO nanoparticles calculated from XRD using Debye Scherrer Formula is 36.27 nm. The size variation of the ZnO nanoparticles is due to the difference in annealing temperature and precursors. The FTIR spectra confirms the formation of ZnO nanoparticle. From UV-Vis spectra of ZnO nanoparticles, the absorption peak is at 380 nm and decreases with time which shows the dye degradation. MB dye degradation efficiency by ZnO nanoparticle is 91.78% in 21 minutes.
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GIUSTINI, ANDREW J., ALICIA A. PETRYK, SHIRAZ M. CASSIM, JENNIFER A. TATE, IAN BAKER, and P. JACK HOOPES. "MAGNETIC NANOPARTICLE HYPERTHERMIA IN CANCER TREATMENT." Nano LIFE 01, no. 01n02 (March 2010): 17–32. http://dx.doi.org/10.1142/s1793984410000067.

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The activation of magnetic nanoparticles (mNPs) by an alternating magnetic field (AMF) is currently being explored as technique for targeted therapeutic heating of tumors. Various types of superparamagnetic and ferromagnetic particles, with different coatings and targeting agents, allow for tumor site and type specificity. Magnetic nanoparticle hyperthermia is also being studied as an adjuvant to conventional chemotherapy and radiation therapy. This review provides an introduction to some of the relevant biology and materials science involved in the technical development and current and future use of mNP hyperthermia as clinical cancer therapy.
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Pancholi, Rashmi. "Different Aspects of Nano-material and Biodegradable Polymers for Cancer Diagnosis and Treatment: A Review." INTERNATIONAL RESEARCH JOURNAL OF ENGINEERING & APPLIED SCIENCES 10, no. 4 (December 30, 2022): 30–42. http://dx.doi.org/10.55083/irjeas.2022.v10i04006.

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Cancer, one of the most prevalent causes of death and disease, has a convoluted pathophysiology. Chemotherapy, immunotherapy and radiation therapy are examples of traditional cancer treatments. However, lack of selectivity, restrictions such cytotoxicity, and Drug resistance is a significant barrier to successful cancer treatment. With the development of nanotechnology, the study of cancer treatment has undergone a revolution. For treatment of cancer Nanoparticles can be used because of their special advantages, less toxicity, more good stability, stronger permeability, and exact placement. There are several varieties of nanoparticles. The innovative nanoparticle based drug delivery system makes advantage of characteristics of the tumour and its surroundings. Nanoparticles overcomes the disadvantages of conventional treatment of cancer in addition to avoiding multiple drug resistance. As additional multidrug resistance mechanisms are found and examined, nanoparticle research is also being pursued actively. The therapy includes consequences of Nano formulation have provided fresh perspectives on cancer treatment. The biggest chunk of studies, however, is restricted to in vivo and in vitro experiments, and the number of authorized Nano drugs has not increased significantly over time. This study covers a wide range of nanoparticle kinds, targeting strategies, and authorized Nanotherapy includes use in the cancer treatment. We also provide a summary of the pros, disadvantages, and present state of clinical translation.
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Moyo, M., K. Kanny, and TP Mohan. "Effects of combined alkali treatment and clay nanoparticle infusion on thermo-mechanical response of kenaf/PLA biocomposites." Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie 40, no. 1 (January 24, 2022): 137–41. http://dx.doi.org/10.36303/satnt.2021cosaami.27.

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Fibre-reinforced biocomposites have inherently low thermo-mechanical properties and hence require some treatments or modifications during the fabrication process in order to enhance these properties. In this work, a combination of alkalization and nanoparticle infusion was used in enhancing thermo-mechanical properties of kenaf fibre-reinforced polylactic acid biocomposites. The biocomposites were made using sodium hydroxide (NaOH) treated kenaf nonwoven mats and polylactic acid infused with clay nanoparticles. Fabrication of the biocomposites was done using the prepreg method and curing at high temperature. Investigation of the thermo-mechanical properties were performed using a thermogravimetric analyser (TGA) and dynamic mechanical analyser (DMA). Results showed that a combination of alkalization and nanoparticle infusion improves the thermal stability of the biocomposites, loss modulus and damping. However, alkalization and nanoparticle infusion decreased the glass transition temperature of the biocomposites. The study shows that combined treatment of biocomposites with sodium hydroxide and clay nanoparticles significantly improves their performance properties. Therefore, this expands the application capabilities of natural fibre reinforced biocomposites. Best results were obtained by a combination of NaOH treatment and infusion with 5 wt% clay nanoparticles.
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CHA, HWA JIN, OK KYUNG PARK, YOUNG HWAN KIM, HYUN GIL CHA, and YOUNG SOO KANG. "TREATMENT OF TiO2 FOR THE SUPPRESSION OF PHOTO-CATALYTIC PROPERTY AND DISPERSION STABILITY." International Journal of Nanoscience 05, no. 06 (December 2006): 795–801. http://dx.doi.org/10.1142/s0219581x06005170.

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To be used as absorber of UV-ray in cosmetic products, UV-ray absorption ability of TiO 2 has to be increased and particle size of TiO 2 has to be reduced up to nanosize. TiO 2 was coated with inorganic layer of silica to suppress photo-catalytic activity and to increase dispersibility. Silica-coated TiO 2 nanoparticle was prepared with commercial TiO 2 (Degussa P-25) and TEOS. TiO 2 was treated with 0.1 M HCl to prevent aggregation. The pH of TEOS was adjusted in the range of 7–8 by adding 0.1 M NH4OH. Silica-coated TiO 2 nanoparticle included the structures of core-shell by TEM images. The decrease of photocatalytic activity and UV shielding effect of silica-coated TiO 2 nanoparticles was confirmed with UV-vis spectra. Improved dispersion of silica-coated TiO 2 nanoparticles as compared with pure TiO 2 was verified with increased Zeta potential value. The dispersion of TiO 2 nanoparticle was also studied on the effect of oleate coating on TiO 2 nanoparticle surface.
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Jin, Guang-Zhen, Atanu Chakraborty, Jung-Hwan Lee, Jonathan C. Knowles, and Hae-Won Kim. "Targeting with nanoparticles for the therapeutic treatment of brain diseases." Journal of Tissue Engineering 11 (January 2020): 204173141989746. http://dx.doi.org/10.1177/2041731419897460.

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Brain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost. Nanoparticles that load and deliver drugs and genes have been intensively studied for the treatment of brain diseases, and have demonstrated some biological effects in various animal models. Among other efforts taken in the nanoparticle development, targeting of blood brain barrier, specific cell type or local intra-/extra-cellular space is an important strategy to enhance the therapeutic efficacy of the nanoparticle delivery systems. This review underlies the targeting issue in the nanoparticle development for the treatment of brain diseases, taking key exemplar studies carried out in various in vivo models.
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Pedraza, A. J., J. D. Fowlkes, D. A. Blom, and H. M. Meyer. "Laser-induced nanoparticle ordering." Journal of Materials Research 17, no. 11 (November 2002): 2815–22. http://dx.doi.org/10.1557/jmr.2002.0409.

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Nanoparticles were produced on the surface of silicon upon pulsed-laser irradiation in the presence of an inert gas atmosphere at fluences close to the melting threshold. It was observed that nanoparticle formation required redeposition of ablated material. Redeposition took place in the form of a thin film intermixed with extremely small nanoparticles possibly formed in the gas phase. Through the use of nonpolarized laser light, it was shown that nanoparticles, fairly uniform in size, became grouped into curvilinear strings distributed with a short-range ordering. Microstructuring of part of the surface prior to the laser treatment had the remarkable effect of producing nanoparticles lying along straight and fairly long (approximately 1 mm) lines, whose spacing equaled the laser wavelength for normal beam incidence. In this work, it is shown that the use of polarized light eliminated the need of an aiding agent: nanoparticle alignment ensued under similar laser treatment conditions. The phenomenon of nanoparticle alignment bears a striking similarity with the phenomenon of laser-induced periodic surface structures (LIPSS), obeying the same dependence of line spacing upon light wavelength and beam angle of incidence as the grating spacing in LIPSS. The new results strongly support the proposition that the two phenomena, LIPSS and laser-induced nanoparticle alignment, evolve as a result of the same light interference mechanism.
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Enas Hatem Kareem, Tamara Natik Dawood, and Firas Rashad Al-Samarai. "Application of Nanoparticle in the Veterinary Medicine." Magna Scientia Advanced Research and Reviews 4, no. 1 (January 30, 2022): 027–38. http://dx.doi.org/10.30574/msarr.2022.4.1.0082.

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Nanotechnology is a modern and developed technology, which have great importance in many fields of medicine (diagnosis and treatment). Also, it used to prevent and solve many problems related to animal production and health. The Nanosystems are including metallic nanoparticles, liposomes, polymeric Nanospheres, polymeric micelles, carbon nanotubes, functionalized fullerenes, polymer-coated Nanocrystals, dendrimers and Nanoshells. Our review showed a details classification of nanoparticles and their uses. Nanoparticles have several features depended on the size, colossal surface. The development of antibiotics nanoparticle is very important and has an excellent impact in treating bacterial infections wherever the antibiotics nanoparticle gives high therapeutic effect without negative side effects. Our review showed some aspects of the nanoparticles' classification and their uses in general form and veterinary medicine, focusing the light on nanoparticle applications in the nutrient, Biocides, meat and egg quality, milk, animal treatment diseases, and reproduction the animals.
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Michelakaki, Irini, Nikos Boukos, Dimitrios A. Dragatogiannis, Spyros Stathopoulos, Costas A. Charitidis, and Dimitris Tsoukalas. "Synthesis of hafnium nanoparticles and hafnium nanoparticle films by gas condensation and energetic deposition." Beilstein Journal of Nanotechnology 9 (June 27, 2018): 1868–80. http://dx.doi.org/10.3762/bjnano.9.179.

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In this work we study the fabrication and characterization of hafnium nanoparticles and hafnium nanoparticle thin films. Hafnium nanoparticles were grown in vacuum by magnetron-sputtering inert-gas condensation. The as deposited nanoparticles have a hexagonal close-packed crystal structure, they possess truncated hexagonal biprism shape and are prone to surface oxidation when exposed to ambient air forming core–shell Hf/HfO2 structures. Hafnium nanoparticle thin films were formed through energetic nanoparticle deposition. This technique allows for the control of the energy of charged nanoparticles during vacuum deposition. The structural and nanomechanical properties of the nanoparticle thin films were investigated as a function of the kinetic energy of the nanoparticles. The results reveal that by proper adjustment of the nanoparticle energy, hexagonal close-packed porous nanoparticle thin films with good mechanical properties can be formed, without any additional treatment. It is shown that these films can be patterned on the substrate in sub-micrometer dimensions using conventional lithography while their porosity can be well controlled. The fabrication and experimental characterization of hafnium nanoparticles is reported for the first time in the literature.
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Osaci, Mihaela, and Matteo Cacciola. "Influence of the magnetic nanoparticle coating on the magnetic relaxation time." Beilstein Journal of Nanotechnology 11 (August 12, 2020): 1207–16. http://dx.doi.org/10.3762/bjnano.11.105.

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Colloidal systems consisting of monodomain superparamagnetic nanoparticles have been used in biomedical applications, such as the hyperthermia treatment for cancer. In this type of colloid, called a nanofluid, the nanoparticles tend to agglomeration. It has been shown experimentally that the nanoparticle coating plays an important role in the nanoparticle dispersion stability and biocompatibility. However, theoretical studies in this field are lacking. In addition, the ways in which the nanoparticle coating influences the magnetic properties of the nanoparticles are not yet understood. In order to fill in this gap, this study presents a numerical simulation model that elucidates how the nanoparticle coating affects the nanoparticle agglomeration tendency as well as the effective magnetic relaxation time of the system. To simulate the self-organization of the colloidal nanoparticles, a stochastic Langevin dynamics method was applied based on the effective Verlet-type algorithm. The Néel magnetic relaxation time was obtained via the Coffey method in an oblique magnetic field, adapted to the local magnetic field on a nanoparticle.
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Dissertations / Theses on the topic "Nanoparticle treatment"

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Fisusi, F. A. "Nanoparticle based strategies for the treatment of glioblastoma." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1456357/.

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Glioblastoma is the most common and most biologically aggressive primary brain tumour in adults. In spite of tremendous investment into research which has led to the development and application of novel diagnostic and therapeutic measures in the management of glioblastoma, the prognosis is still dismal with median survival time of about 12 – 15 months. Also, the success of most cytotoxic drugs clinically employed in the treatment of glioblastoma is greatly limited by their dose-limiting toxicity which typically manifests as clinically significant reduction in blood cell counts. The aim of this study is to demonstrate that a high dose nanoparticle formulation of the cytotoxic drug lomustine using a self-assembling chitosan amphiphile, quaternary ammonium palmitoyl glycol chitosan would lead to improved survival outcomes without a commensurate increase in toxic effects. The novel nanoparticle based lomustine formulation employed in this study enabled the administration of a lomustine dose (13 mg kg-1) 10 times higher than the dose (1.2 mg kg-1) achievable with an ethanolic formulation of lomustine. Human glioblastoma tumour bearing mice treated with the high dose formulation had a mean survival time of 33.1 days while the mice treated with the low dose formulation had a mean survival time of 22.5 days after intravenous administration of the drug once daily for 10 consecutive days. The increased (1.5 times longer) survival time resulting from treatment with the nanoparticle based high dose formulation was not accompanied by an increase in gross toxic effects. Thus, the nanoparticle based formulation afforded the administration of lomustine in a continuous high dose schedule which led to beneficial therapeutic outcomes. In addition, three self-assembling peptide amphiphiles were synthesised and characterised for potential application in the transport and delivery of therapeutic molecules to the brain for the treatment of intracranial tumours.
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Wallat, Jaqueline Diane. "Fluorous Nanoparticle Platform for Cancer Imaging and Treatment." Case Western Reserve University School of Graduate Studies / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=case1513787381901888.

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Phelane, Lisebo. "Metal nanoparticle modified polysulfone membrane for water treatment." Thesis, University of the Western Cape, 2013. http://hdl.handle.net/11394/4480.

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>Magister Scientiae - MSc
Membrane separation processes have been widely applied in the treatment of wastewater with polysulfone (PSF) polymer membrane being the most frequently used in ultrafiltration of wastewater due to its chemical and structural stability and mechanical robustness. The disadvantage to these membranes is their hydrophobicity which leads to membrane fouling caused by organic pollutants in water. Many studies have been conducted to increase the hydrophilic properties of the polysulfone membrane surface. Most recently metal oxide nanoparticles have been introduced to the polymer matrix in order to reduce membrane fouling and increase its hydrophilicity with measurable success. Natural organic matters are the one of the major fouling agents during ultrafiltration, reverse osmosis and microfiltration. Two organic acids (Tannic Acid and Alginic Acid) were selected to test the fouling behaviour of nanometallic synthesised polysulfone membranes. For this study, polysulfone casting suspension was prepared by dissolving polysulfone beads in N,N-dimethly acetamide. Three metallic nanoparticles of Silver, Cobalt and Nickel were selected to improve the hydrophilicity of the polysulfone membrane. The metal nanoparticles were prepared using the chemical reduction method. Cobalt nanoparticles were synthesized by dissolving the cobalt chloride salt in deionized water and reduced with sodium borohydride at room temperature. The nickel chloride salt was dissolved in ethanol and reduced with sodium borohydride under magnetic stirrer. Silver nanoparticles were prepared by dissolving the silver nitrate in deionised water and heated to boil, the sodium citrate was added to reduced the silver nitrate. These nanoparticles were then integrated into the polysulfone polymer matrix to form the metal nanoparticle polysulfone nanocomposites. This study focused on four prepared polysulfone nanocomposite membrane; 1 unmodified polysulfone (PSF), 2 polysulfone modified with cobalt nanoparticles (PSF/Co), 3 polysulfone modified with nickel nanoparticles (PSF/Ni) and 4 polysulfone modified with silver nanoparticles (PSF/Ag).
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Peters, David Thomas. "Targeting atherosclerosis nanoparticle delivery for diagnosis and treatment /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3339266.

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Thesis (Ph. D.)--University of California, San Diego, 2009.
Title from first page of PDF file (viewed February 10, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Restis, Eva Marie. "Development of Drug Loaded Nanoparticles for Treatment of Mycobacterium avium Infection." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/52565.

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Currently, about one third of the world's population is latently infected with Mycobacterium tuberculosis and about 4 million people die from the disease annually worldwide. Although treatment with antimicrobials can be curative, many people fail to complete the prescribed therapeutic regimen which can increase the risk of disease re-emergence, spread of infection to others and development of drug resistance. An improved approach is urgently needed for patient compliance. Development of safe and effective colloidal drug delivery systems may reduce the amount and frequency of antimicrobial therapy needed. The major goal of this research effort is to explore the safety and efficacy of antimicrobial loaded nanoparticles against M. avium. Various in vitro efficacy studies were done with a) amikacin-loaded nanoparticles, b) clarithromycin-loaded nanoparticles, and c) with aerogel nanoparticles loaded with rifampicin, clarithromycin and ethambutol. Clarithromycin (CLA) and amikacin (AMK) loaded nanoparticles showed a significant reduction in viable M. avium compared to free antibiotics and untreated controls. Cytotoxicity assays revealed that all types of drug-laden nanoparticles were non-toxic to J774A.1 mouse macrophage cells at therapeutic doses. In vivo efficacy studies showed that only amikacin-loaded polymeric nanoparticles improved clearance compared to free amikacin in M. avium infected BALB/c mice. In general, none of the nanoparticle formulations elicited any significant microscopic lesions in the organs of infected mice at tested doses. Each nanoparticle formulation was analyzed physicochemically for size, zeta potential, amount of drug load, minimum inhibitory concentration (MIC) and stability. Both the AMK and CLA polymeric nanoparticles were below 200 nm in size and had a slightly negative overall surface charge, aerogel nanoparticles were somewhat larger in size. The amount of drug load varied between all three nanoparticles and is largely dependent on the chemical structure and interactions between the nanoparticle and drug. The AMK and CLA nanoparticles were relatively stable under varying environmental conditions and time points and had MIC ranges equivalent to the respective free drugs.
Ph. D.
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Andersson, Mikael. "Modeling and characterization of magnetic nanoparticles intended for cancer treatment." Thesis, Uppsala universitet, Fasta tillståndets fysik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199055.

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Cancer is one of the challenges for today's medicine and therefore a great deal of effort is being put into improving known methods of treatment and developing new ones. A new method that has been proposed is magnetic hyperthermia where magnetic nanoparticles linked to the tumor dissipate heat when subjected to an alternating magnetic field and will thus increase the temperature of the tumor. This method makes the tumor more susceptible to radiation therapy and chemotherapy, or can be used to elevate the temperature of the tumor cells to cause cell death. The particles proposed for this are single core and often have a size in the range of 10 nm to 50 nm. To achieve an effective treatment the particles should have a narrow size distribution and the proper size. In this work, a theoretical model for predicting the heating power generated by magnetic nanoparticles was evaluated. The model was compared with experimental results for magnetite particles of size 15 nm to 35 nm dissolved in water. The properties of the particles were characterized, including measurements of the magnetic saturation, the effective anisotropy constant, average size and size distribution. To evaluate the results from the model the AC susceptibility and heating power were experimentally determined. The model is a two-step model. First the out-of-phase component of the AC susceptibility as a function of frequency is calculated. Then this result is used to calculate the heating power. The model gives a correct prediction of the shape of the out-of-phase component of the susceptibility but overestimates its magnitude. Using the experimentally determined out-of-phase component of the susceptibility, the model estimation of the heating power compares quite well with the measured values.
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Wu, Xingchen. "Multiple sclerosis : MRI diagnosis, potential treatment and future potential for nanoparticle applications /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-515-1/.

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Lin, Kevin (Kevin Yu-Ming). "Nanoparticle systems that exploit host biology for diagnosis and treatment of disease." Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/98337.

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Thesis: Sc. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2014.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 131-151).
Over the past 30 years, advances in nanotechnology have generated a multitude of nanostructures exhibiting a breadth of physical, chemical, and biological properties that have tremendous potential to improve the detection and treatment of disease. Despite this progress, biomedical nanotechnologies have yet to approach the same level of complexity as biological systems, which produce higher-order functions through coordinated interactions between multiple nanoscale components. This thesis aims to explore the potential of nanoparticles to interface with the host biology to perform systems-level applications that benefit disease sensing and treatment. First, we engineered nanoparticles to sense dysregulated protease activity associated with thrombosis and generate reporters that can be noninvasively quantified in the urine. These nanoparticles exploit the vascular transport of the circulatory system and the size filtration function of the renal system to emit reporters into the urine following proteolytic cleavage events. The reporter levels in the urine differentiate between healthy and thrombotic states and correlate with clot burden in a mouse model of pulmonary embolism. Next, we developed nanoparticles that homeostatically regulate the biological cascade responsible for haemostasis to prevent the aberrant formation of clots. These nanoparticles form a negative feedback loop with thrombin, a key enzyme in the coagulation cascade, to regulate their release of the anticoagulant heparin. In mice, they inhibited the formation of pulmonary embolisms without an associated increase in bleeding, the primary side-effect of antithrombotic therapy in the clinic. Finally, we investigated a two-component system whereby the first therapeutic entity induces the upregulation a molecular signal within a malignant environment to amplify the local recruitment of a secondary population of targeted nanoparticles. Here, the interaction between the initial therapeutic and the targeted nanoparticles occurred indirectly through a biological stress pathway. This cooperative targeting system delivered up to five-fold higher nanoparticle doses to tumors than non-cooperative controls, leading to delayed tumor growth and improved survival in mice. Together, these systems highlight the potential for interactive nanoparticle systems to perform highly complex functions in vivo by leveraging and modulating the host biology. In contrast to the current strategy of injecting large populations of nanoparticles that carry out identical, pre-defined tasks with little to no feedback from the in vivo environment, this work supports the construction of nanoparticle systems that leverage both synthetic and endogenous components to produce emergent behaviors for enhancing diagnostics and therapeutics.
by Kevin Lin.
Sc. D.
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Uppalapati, Lakshmi. "Peptides as therapeutics and active gene delivery vehicles for cancer treatment." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/35231.

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Doctor of Philosophy
Department of Agronomy
Masaaki Tamura
Over the years proteins/peptides have evolved as promising therapeutic agents in the treatment of cancer. Considering the advantages of peptides such as their small size, ease of synthesis, tumor-penetrating ability and bio-compatibility, present report discusses proof of concept for 1. C1B5 peptide of protein kinase Cγ and a low dose of gemcitabine combination treatment for peritoneally disseminated pancreatic cancer and 2. dTAT peptide nanoparticles mediated gene (angiotensin II type 2 receptor gene) therapy for lung cancer. 1. A significant reduction in intraperitoneally (IP) transplanted pancreatic carcinoma growth was demonstrated with C1B5 peptide and gemcitabine co-treatment in an immunocompetent mouse model. Increased number of Granzyme B positive cells was observed in treated mice ascites, suggesting the involvement of immune response in tumor attenuation. The strong effect observed in combination treatment might be because of increase in lymphocyte recruitment by gemcitabine followed by C1B5 peptide mediated CD8+ T-cells or NK cells activation apart from direct cancer cell apoptosis. 2. To test dTAT peptide nanoparticles (dTAT NPs) mediated therapeutic gene delivery, luciferase reporter gene containing dTAT nanoparticles were synthesized (dTAT/pLUC/Ca2+). Synthesis conditions for nanoparticles were optimized based on dTAT/pLUC/Ca2+ nanoparticles transfection efficiency. With the optimized conditions, dTAT NPs containing AT2R, TRAIL or miR-34a pDNA (dTAT/pAT2R, dTAT/TRAIL or dTAT/miR- 34a) were synthesized. Therapeutic potential of these NPs was analyzed in lung adenocarcinoma containing mice by administering them intravenously (IV) or/and intratracheally (IV). Combination treatment with the IV injection of the new dTAT/pAT2R/Ca2+ formulation and the IT injection of the original dTAT/pAT2R/Ca2+ formulation is effective in attenuation of developed human bronchioloalveolar carcinoma in the SCID mouse lungs. Findings from the above mentioned studies have vital clinical relevance as it implies that peptides alone or when used as gene delivery systems may prove to be beneficial in the treatment of various stages of cancer.
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Seyedi, Seyed Mojtaba. "Engineered iron oxide nanoparticle-polymer composites for the removal of dissolved arsenic and antimony." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2017. https://ro.ecu.edu.au/theses/2038.

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Dissolved metalloids, such as arsenic (As), antimony (Sb) and boron (B), are often found in contaminated surface waters or groundwater. Their removal is essential for protecting the water environment. This MEngSci research project investigated the use of magnetite (Fe3O4) nanoparticle – polymethylmethacrylate (PMMA) composites, as a reusable adsorbent toremove dissolved As andSb. Comparative experiments were carried out to examine the effectiveness ofcommercial magnetite nanoparticles, lab synthesized nanoparticles, and the composites of synthesed Fe3O4nanoparticle-PMMA, for adsorbing As (III) and Sb (III) ions. The effects of major environmental and operating parameters (e.g. pH and adsorbent dosage) were investigated.Four cycles of adsorption-desorption experiment were conducted; the results demonstrating significant capability of the composites of removing the dissolved metalloids. In addition, the competitive adsorption of As and Sb to the composites was studied in batch experiments. It was found that the affinity of antimony to the adsorbents was generally greater than arsenic ions. A variety of analytical methods, such as X-Ray Diffraction (XRD), microwave plasma atomic emission spectrometry (MP-AES) and Malvern Zetasizer, were used to characterise the properties of the composites and analyze dissolved As and Sb concentrations. Details of the experimentalprocedures and results have been presented in this MEngSci thesis. Overall, this research validated: (a) a process to synthesize Fe3O4 nanoparticle-PMMA composites; and (b) the efficiency of using the composites to remove dissolved metalloids from contaminated water.
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Books on the topic "Nanoparticle treatment"

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Caruso, Gerardo. Nanoparticles and brain tumor treatment. New York: ASME Press, 2012.

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Padhi, Santwana, Anindita Behera, and Eric Lichtfouse, eds. Polymeric nanoparticles for the treatment of solid tumors. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-14848-4.

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Parfenyuk, E. V. Silica nanoparticles as drug delivery system for immunomodulator GMDP. New York, N.Y: ASME, 2012.

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(Society), SPIE, ed. Energy-based treatment of tissue and assessment VII: 3-4 February 2013, San Francisco, California, United States. Bellingham, Washington: SPIE, 2013.

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Ryan, Thomas P. Energy-based treatment of tissue and assessment VI: 23-24 January 2011, San Francisco, California, United States. Bellingham: SPIE, 2011.

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Dimosthenis, Stamopoulos, ed. Magnetically assisted hemodialysis: A new strategy for the treatment of end stage renal disease. New York: Nova Science Publishers, 2008.

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Gali-Muhtasib, Hala, and Racha Chouaib. Nanoparticle Drug Delivery Systems for Cancer Treatment. Jenny Stanford Publishing, 2020.

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Gali-Muhtasib, Hala, and Racha Chouaib. Nanoparticle Drug Delivery Systems for Cancer Treatment. Jenny Stanford Publishing, 2020.

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Gali-Muhtasib, Hala, and Racha Chouaib. Nanoparticle Drug Delivery Systems for Cancer Treatment. Jenny Stanford Publishing, 2020.

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Nanoparticle Drug Delivery Systems for Cancer Treatment. Taylor & Francis Group, 2020.

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Book chapters on the topic "Nanoparticle treatment"

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Binns, Chris. "Magnetic Nanoparticle Hyperthermia Treatment of Tumours." In Nanostructured Materials for Magnetoelectronics, 197–215. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-34958-4_8.

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Yadav, Ravi Kumar, Amit Kumar Singh, N. B. Singh, Niharika, Niharika Singh, Shubhra Khare, and Abhay K. Pandey. "Green Synthesized Nanoparticle-Mediated Wastewater Treatment." In Emerging Eco-friendly Green Technologies for Wastewater Treatment, 299–309. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-1390-9_13.

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Saie, Amir Ata, Moumita Ray, Morteza Mahmoudi, and Vincent M. Rotello. "Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics." In Cancer Treatment and Research, 245–73. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-16555-4_11.

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Madkour, Loutfy H. "Codelivery in Nanoparticle-based siRNA for Cancer Therapy." In Nanoparticle-Based Drug Delivery in Cancer Treatment, 127–50. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003229674-4.

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Madkour, Loutfy H. "Recent Advances of Nanotechnologies for Cancer Immunotherapy Treatment." In Nanoparticle-Based Drug Delivery in Cancer Treatment, 455–513. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003229674-15.

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Madkour, Loutfy H. "Pharmacokinetics, Biodistribution, and Therapeutic Applications of Recently Developed siRNA and DNA Repair Genes Recurrence." In Nanoparticle-Based Drug Delivery in Cancer Treatment, 363–94. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003229674-12.

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Madkour, Loutfy H. "DNA/RNA Nanoparticles Structures for siRNA Delivery Applications." In Nanoparticle-Based Drug Delivery in Cancer Treatment, 105–26. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003229674-3.

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Madkour, Loutfy H. "Nanoparticle–Based RNA (siRNA) Combination Therapy Toward Overcoming Drug Resistance in Cancer." In Nanoparticle-Based Drug Delivery in Cancer Treatment, 187–214. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003229674-6.

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Madkour, Loutfy H. "Small Interfering RNAs, MicroRNAs, and NPs in Gynecological Cancers." In Nanoparticle-Based Drug Delivery in Cancer Treatment, 151–86. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003229674-5.

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Madkour, Loutfy H. "Application of Carbon Nanotubes in Cancer Vaccines as Drug Delivery Tools." In Nanoparticle-Based Drug Delivery in Cancer Treatment, 275–310. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9781003229674-9.

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Conference papers on the topic "Nanoparticle treatment"

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Vu, Trinh, Highqueen Sarpomah, Michael Kamen, Tolessa Deksissa, and Jiajun Xu. "Nanoparticles Infused Mesoporous Material for Water Treatment Processes." In ASME 2017 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/imece2017-70475.

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In current study, a hybrid mesoporous material infused with metallic oxide nanoparticles, MCM-48 with TiO2 nanoparticles, has been developed for potential application in water treatment. Using this unique hybrid structure, it can combine the advantages of the effective pollutants removal capability of metallic oxide nanoparticles, and the strong yet high permeable structure of mesoporous material. A modified hydrothermal method has been developed to synthesize three hybrid samples with TiO2 nanoparticles of three assorted sizes (15, 50 and 300nm), and their structure have also been characterized. The synthesized samples are tested for its capability of removing organic dye and trace metals using ICP-MS. The results have shown that while all three hybrid materials have shown over 80% adsorption rate for organic dye, the sample synthesized using 300nm TiO2 nanoparticle has shown the highest adsorption rate. Similarly, the highest adsorption rate for most trace metals test here also occurs in the sample made with 300nm TiO2 nanoparticle. Coincidentally, the sample prepared with 300nm TiO2 nanoparticle has a much larger internal surface area and smaller average pore size compared to the two other samples, which may lead to the higher adsorption rate of trace metals and organic dye tested here. This study has presented a hybrid mesoporous material that can be potentially used for pollutants removal of water treatment. Future studies are still needed to fully explore this hybrid material and its capability in water treatment.
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Etheridge, Michael L., and John C. Bischof. "Investigating Electromagnetic Field, Nanoparticle Design, and Treatment Volume for Magnetic Nanoparticle Thermal Therapy." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80779.

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Magnetic nanoparticle (MNP) based thermal therapies are currently approved in Europe and poised for clinical translation in the US. The main benefits include the ability to focally and repeatedly treat tissues, including cancers, with a minimally-invasive platform. Nevertheless, a more complete understanding and control of MNP heating is necessary to effectively translate the approach to treat different sizes and geometries of cancer (See Figure 1). The present work discusses contrasts in heating between superparamagnetic and ferromagnetic nanoparticles (sMNP and fMNP), electromagnetic field-dependant MNP response, scaling of MNP volumetric heating, and the ability of theory to predict this behavior.
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Kupwade-Patil, K., T. J. John, B. Mathew, H. Cardenas, and H. Hegab. "Diffusion Analysis of Chloride in Concrete Following Electrokinetic Nanoparticle Treatment." In ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASMEDC, 2010. http://dx.doi.org/10.1115/fedsm-icnmm2010-31153.

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Concrete is a highly porous material which is susceptible to the migration of highly deleterious species such as chlorides and sulfates. Various external sources including sea salt spray, direct sea water wetting, deicing salts and brine tanks harbor chlorides that can enter reinforced concrete. Chlorides diffuse into the capillary pores of concrete and come into contact with the rebar. When chloride concentration at the rebar exceeds a threshold level it breaks down the passive layer of oxide, leading to chloride induced corrosion. Application of electrokinetics using positively charged nanoparticles for corrosion protection in reinforced concrete structures is an emerging technology. This technique involves the principle of electrophoretic migration of nanoparticles to hinder chloride diffusion in the concrete. The re-entry of the chlorides is inhibited by the electrodeposited assembly of the nanoparticles at the rebar interface. In this work electrochemical impedance spectroscopy (EIS) combined with equivalent circuit analysis was used to predict chloride diffusion coefficients as influenced by nanoparticle treatments. Untreated controls exhibited a diffusion coefficient of 3.59 × 10−12 m2/s which is slightly higher than the corrosion initiation benchmark value of 1.63 × 10−12 m2/s that is noted in the literature for mature concrete with a 0.5 water/cement mass ratio. The electrokinetic nanoparticle (EN) treated specimens exhibited a diffusion coefficient of 1.41 × 10−13m2/s which was 25 times lower than the untreated controls. Following an exposure period of three years the mature EN treated specimens exhibited lower chloride content by a factor of 27. These findings indicate that the EN treatment can significantly lower diffusion coefficients thereby delaying the initiation of corrosion.
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Su, Di, Ronghui Ma, and Liang Zhu. "Numerical Study of Nanofluid Transport in Tumors During Nanofluid Infusion for Magnetic Nanoparticle Hyperthermia Treatment." In ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/mnhmt2012-75101.

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The application of nanostructures in hyperthermia treatment of cancer has attracted growing research interest due to the fact that magnetic nanoparticles are able to generate impressive levels of heat when excited by an external magnetic field [1–3]. Various types of nanoparticles such as magnetite and superparamagentic iron oxide nanoparticles have demonstrated great potentials in hyperthermia treatment; however many challenges need to be addressed for future applications of this method in clinical studies. One leading issue is the limited knowledge of nanoparticle distribution in tumors. Since the temperature elevation is induced as the result of the heat generation by the nanoparticles, the concentration distributions of the particles in a tumor play a critical role in determining the efficacy of the treatment. The lack of control of the nanoparticle distribution may lead to inadequacy in killing tumor cells and/or damage to the healthy tissue.
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Salloum, M., R. Ma, and L. Zhu. "Controlling Nanoparticle Delivery in Hyperthermia for Cancer Treatment: In Vitro Experimental Study." In ASME 2007 International Mechanical Engineering Congress and Exposition. ASMEDC, 2007. http://dx.doi.org/10.1115/imece2007-43443.

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Magnetic nanoparticle hyperthermia attracts growing research interest aiming to develop a localized heating approach for malignant tumors treatment. In this method, magnetic nanoparticles delivered to the tissue or blood vessels induce localized heating when exposed to alternating magnetic field, leading to irreversible thermal damage to the tumor. Controlling the heat distribution and temperature elevation in such treatment is still an immense challenge in clinical applications. In this study, we inject nanofluid into agarose gel to study nanofluid transport in the extracellular space of biological tissue. Nanofluid distribution in the gel is examined via digital images of the nanofluid spreading in the gel. By adjusting gel concentrations and injection flow rates, we expect to identify an idealized particle delivery strategy for achieving spherical shaped nanoparticle dispersion. Thermocouples are then inserted into the gel to measure the initial temperature rises at various locations in the gel to obtain the specific absorption rate (SAR). The preliminary results have demonstrated that a spherical shaped particle deposition is possible with a relatively low injection rate of the nanofluid and a technique that minimizes the air gap surrounding the injection needle. The distribution of energy absorption (SAR) implies that the nanoparticle distribution in the gel is not uniform. High concentration of nanoparticles is observed close to the center of the injection site. Based on the particle deposition pattern, a theoretical model will be developed in the future to simulate the temperature distribution in tissue during nanoparticle hyperthermia treatment. The simulated results will help provide guidance for designing a better treatment protocol in future clinical application.
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Attaluri, Anilchandra, Ronghui Ma, and Liang Zhu. "Quantification of Nanoparticle Distribution in Tissue After Direct Injection Using MicroCT Imaging." In 2010 14th International Heat Transfer Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/ihtc14-22139.

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Magnetic nanoparticles have been used in clinical and animal studies to generate localized heating for tumor treatments when the particles are subjected to an external alternating magnetic field. One approach to deliver the nanoparticles is via directly injecting the nanoparticles in the extracellular space of the tumor. Its advantage is that multiple-site injections can be exploited to cover the entire target region in the case of an irregularly shaped tumor. Currently since most tissue is opaque, the detailed information of the nanoparticle spreading after the injection can not be visualized directly and it is often quantified by indirect methods such as temperature measurements to inversely determine the distribution. In this study, we use a high-resolution microCT imaging system to investigate the nanoparticle concentration distribution in a tissue equivalent agarose gel. The preliminary results are promising to obtain a 3-D distribution of the ferrofluid in tissue. The local density variations induced by the nanoparticles in the vicinity of the injection site can be detected and analyzed by the microCT system. Experiments are performed to study how the injection amount, gel concentration, and nanoparticle concentration in the ferrofluid affect nanoparticle spreading in the gel. The obtained quantified information is important for future studies of temperature elevations in opaque tumor to design optimized treatment protocols.
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Soni, Sanjeev, Himanshu Tyagi, Robert A. Taylor, and Amod Kumar. "Effect of Nanoparticle Concentration on Thermal Damage in Nanoparticle-Assisted Thermal Therapy." In ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/mnhmt2016-6418.

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Photothermal therapy involving nanoparticles is evolving as a promising targeted treatment for cancer. This paper presents the results for the effect of nanoparticle concentration, within a tumor, to control the thermal damage during nanoparticle assisted thermal therapy. A surface tumor embedded with gold nanoparticles (distributed uniformly) is considered. The thermal damage is evaluated for various nanoparticle concentrations (within the tumor) to identify an optimal concentration of the nanoparticles so as to achieve spatial confinement of the damage to the tumor region. Optical interaction is coupled to the biological heat transfer through Pennes’ bioheat model and Beer’s law. Spatiotemporal thermal damage is simulated through the Arrhenius method. The finite difference implicit method is used to solve the coupled phenomenon. Results show that there is a specific value of nanoparticle concentration at which it is possible to confine thermal damage to the tumor within a spatial scale of less than 1 mm. This way the healthy tissues surrounding a tumor are safe. This optimum value of nanoparticle concentration (irrespective of tumor diameters) is 0.00001%. This concentration along with irradiation intensity of 1 W/cm2 for irradiation duration of 110 seconds is sufficient to thermally ablate the considered tumors. Novelty of this study is that it presents a combination of the controlling parameters for achieving a high (<1 mm) spatial confinement of the thermal damage. This finding is very much significant from clinical point of view. Clinically it is always desired to attain the therapeutic efficacy with minimal delivery of external agents (nanoparticles in this case) to a patient.
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LeBrun, A., N. Conn, A. Attaluri, N. Manuchehrabadi, Z. Huang, R. Ma, and L. Zhu. "Quantification of MicroCT Image Intensity and Nanoparticle Concentration in Agarose Gel." In ASME 2012 Third International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/mnhmt2012-75025.

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In recent years, magnetic nanoparticle hyperthermia has attracted a lot of attentions in cancer treatment due to its ability to confine heat within the tumor with minimal collateral thermal damage to the surrounding healthy tissue.1–4 The success of the treatment using magnetic nanoparticles depends on careful planning of the heating duration and achieved temperature elevations. It has been demonstrated by previous research that the generated volumetric heat generation rate or Specific Absorption Rate (SAR) should be proportional to the nanoparticle concentration distribution in the tumors. The difficulty encountered by bioengineers is that the nanoparticle concentration distribution is often unknown, since the tissue is opaque. Recently, high-resolution microCT imaging technique has been used to visualize magnetic nanoparticle distribution in tumors. MicroCT has been shown to generate detailed 3-D density variations induced by nanoparticle depositions in both tissue-equivalent gels and tumor tissues.5–6 However, experimental studies are still needed to quantify the relationship between the microCT pixel index number shown in the scanned images and the actual nanoparticle concentrations.
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Laakso, Petri, Saara Ruotsalainen, Eerik Halonen, Matti Mäntysalo, and Antti Kemppainen. "Sintering of printed nanoparticle structures using laser treatment." In ICALEO® 2009: 28th International Congress on Laser Materials Processing, Laser Microprocessing and Nanomanufacturing. Laser Institute of America, 2009. http://dx.doi.org/10.2351/1.5061499.

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Petryk, A. A., A. J. Giustini, P. Ryan, R. R. Strawbridge, and P. J. Hoopes. "Iron oxide nanoparticle hyperthermia and chemotherapy cancer treatment." In SPIE BiOS: Biomedical Optics, edited by Thomas P. Ryan. SPIE, 2009. http://dx.doi.org/10.1117/12.810024.

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Reports on the topic "Nanoparticle treatment"

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Basu, Sayani. Nanoparticle-Based Therapeutics for the Treatment of Stroke. Nature Library Ltd, November 2020. http://dx.doi.org/10.47496/nl.blog.13.

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Venedicto, Melissa, and Cheng-Yu Lai. Facilitated Release of Doxorubicin from Biodegradable Mesoporous Silica Nanoparticles. Florida International University, October 2021. http://dx.doi.org/10.25148/mmeurs.009774.

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Cervical cancer is one of the most common causes of cancer death for women in the United States. The current treatment with chemotherapy drugs has significant side effects and may cause harm to healthy cells rather than cancer cells. In order to combat the potential side effects, nanoparticles composed of mesoporous silica were created to house the chemotherapy drug doxorubicin (DOX). The silica network contains the drug, and a pH study was conducted to determine the conditions for the nanoparticle to disperse the drug. The introduction of disulfide bonds within the nanoparticle created a framework to efficiently release 97% of DOX in acidic environments and 40% release in neutral environments. The denotation of acidic versus neutral environments was important as cancer cells are typically acidic. The chemistry was proved with the incubation of the loaded nanoparticle into HeLa cells for a cytotoxicity report and confocal imaging. The use of the framework for the anticancer drug was shown to be effective for the killing of cancerous cells.
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Li, Xu, and Alan Sahakian. Nanoparticle Contrast Agents for Enhanced Microwave Imaging and Thermal Treatment of Breast Cancer. Fort Belvoir, VA: Defense Technical Information Center, October 2009. http://dx.doi.org/10.21236/ada565499.

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Lelievre, Sophie. Channeling Nanoparticles for Detection and Targeted Treatment of Breast Cancerous Lesions. Fort Belvoir, VA: Defense Technical Information Center, October 2011. http://dx.doi.org/10.21236/ada555798.

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Tomasson, Michael. Treatment of Multiple Myeloma with VLA4-targeted Nanoparticles Delivering Novel c-MYC Inhibitor Prodrug. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada585947.

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Hubbard, Madeline. Impact of Titanium Dioxide Nanoparticles on Nutrient and Contaminant Reduction in Wastewater Treatment Wetlands. Portland State University, December 2019. http://dx.doi.org/10.15760/ccemp.49.

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Everts, Maaike, and Vaibhav Saini. A Targeted Multifunctional Platform for Imaging and Treatment of Breast Cancer and Its Metastases Based on Adenoviral Vectors and Magnetic Nanoparticles. Fort Belvoir, VA: Defense Technical Information Center, August 2007. http://dx.doi.org/10.21236/ada474672.

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