Journal articles: 'Nanoparticle tags'

1

Gao, Zhiqiang, and Zichao Yang. "Detection of MicroRNAs Using Electrocatalytic Nanoparticle Tags." Analytical Chemistry 78, no. 5 (March 2006): 1470–77. http://dx.doi.org/10.1021/ac051726m.

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Yang, Chih-Tsung, Lin Wu, Ping Bai, and Benjamin Thierry. "Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags." Journal of Materials Chemistry C 4, no. 41 (2016): 9897–904. http://dx.doi.org/10.1039/c6tc03981b.

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He, Han, Lauri Sydänheimo, Johanna Virkki, and Leena Ukkonen. "Experimental Study on Inkjet-Printed Passive UHF RFID Tags on Versatile Paper-Based Substrates." International Journal of Antennas and Propagation 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/9265159.

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We present the possibilities and challenges of passive UHF RFID tag antennas manufactured by inkjet printing silver nanoparticle ink on versatile paper-based substrates. The most efficient manufacturing parameters, such as the pattern resolution, were determined and the optimal number of printed layers was evaluated for each substrate material. Next, inkjet-printed passive UHF RFID tags were fabricated on each substrate with the optimized parameters and number of layers. According to our measurements, the tags on different paper substrates showed peak read ranges of 4–6.5 meters and the tags on different cardboard substrates exhibited peak read ranges of 2–6 meters. Based on their wireless performance, these inkjet-printed paper-based passive UHF RFID tags are sufficient for many future wireless applications and comparable to tags fabricated on more traditional substrates, such as polyimide.

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Boca, Sanda, Dumitrita Rugina, Adela Pintea, Nicolae Leopold, and Simion Astilean. "Designing Gold Nanoparticle-Ensembles as Surface Enhanced Raman Scattering Tags inside Human Retinal Cells." Journal of Nanotechnology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/961216.

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Apart from the traditional development of surface-enhanced raman scattering (SERS) substrates for ultrasensitive spectroscopic analysis, an increasing interest is given nowadays to the design of the so-called SERS nanotags which integrate multiple SERS applications into single plasmonic nanoparticles. The fabrication of SERS tags is still a challenging task due to the complicated fabrication process. Typically, SERS tags are hybrid nanoconstructs consisting in a unique plasmonic nanoobject encoded with specific reporter molecules and enveloped in a protective shell that provides both biocompatibility and targeting function. Herein, we produce effective SERS tags consisting in small aggregates of gold nanoparticles (mainly dimers and trimers) which are captured from solution and then transferred into cells to perform as individual plasmonic nanostructures. Actually the small aggregates formed under controlled conditions are stabilized in solution by interlocking into a polymeric envelope made of thiol-modified poly(ethylene) glycol (PEG-SH). No further encoding operation is necessary in our case since part of ascorbic acid used as reducing agent remains attached in the interparticle junctions, providing persistent and strong SERS signal when the fabricated tags are internalized by human retinal cells. Our studies demonstrate a promising potential of new SERS-active nanoparticles to serve as effective reporters for biomedical tracing and imaging.

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Liu, Guodong, Hong Wu, Alice Dohnalkova, and Yuehe Lin. "Apoferritin-Templated Synthesis of Encoded Metallic Phosphate Nanoparticle Tags." Analytical Chemistry 79, no. 15 (August 2007): 5614–19. http://dx.doi.org/10.1021/ac070086f.

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Huang, Chien Wen, Yao Wu Hao, James Nyagilo, Digant P. Dave, Li Feng Xu, and Xian Kai Sun. "Porous Hollow Gold Nanoparticles for Cancer SERS Imaging." Journal of Nano Research 10 (April 2010): 137–48. http://dx.doi.org/10.4028/www.scientific.net/jnanor.10.137.

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Surface enhanced Raman spectroscopy (SERS) is a promising molecular imaging modality capable of simultaneously detecting multiple molecular biomarkers. With the biocompatibility and functionalizability of Au, Au-nanoparticle based Raman tags possess the potential for in vivo SERS cancer biomarker detection. Here, we report the large scale synthesis of a new type of Au nanoparticles, Porous Hollow Au Nanoparticles (PHAuNPs), and demonstrate their potential application as SERS imaging tags. PHAuNPs feature a sub-20 nm porous shell and a 50 nm void core. Such unique morphology enables them to strongly absorb and scatter near infrared lights due to the surface plasmon resonant effect of Au. This makes them particularly suitable for in vivo applications, where NIR wavelengths are considered as a ‘clear window’ for deeper penetration of light. The construction and characterization of PHAuNP-based Raman nanotag, including attachment of Raman dye, pegylation and their stability, are described. Cytotoxicity of Raman nanotags are tested using the radioactive [3H]thymidine incorporation method. The results show that pegylated Raman nanotags are stable and non-toxic and can potentially be used for in vivo applications.

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Yang, Chih-Tsung, Lin Wu, Ping Bai, and Benjamin Thierry. "Correction: Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags." Journal of Materials Chemistry C 4, no. 44 (2016): 10562. http://dx.doi.org/10.1039/c6tc90191c.

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Correction for ‘Investigation of plasmonic signal enhancement based on long range surface plasmon resonance with gold nanoparticle tags’ by Chih-Tsung Yang et al., J. Mater. Chem. C, 2016, 4, 9897–9904.

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Zolfigol, Mohamad Ali, Maliheh Safaiee, and Neda Bahrami-Nejad. "Correction: Dendrimeric magnetic nanoparticle cores with Co-phthalocyanine tags and their application in the synthesis of tetrahydrobenzo[b]pyran derivatives." New Journal of Chemistry 40, no. 9 (2016): 8158–60. http://dx.doi.org/10.1039/c6nj90033j.

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Correction for ‘Dendrimeric magnetic nanoparticle cores with Co-phthalocyanine tags and their application in the synthesis of tetrahydrobenzo[b]pyran derivatives’ by Mohamad Ali Zolfigol et al., New J. Chem., 2016, 40, 5071–5079.

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An, Xingda, Ayan Majumder, James McNeely, Jialing Yang, Taranee Puri, Zhiliang He, Taimeng Liang, John K. Snyder, John E. Straub, and Björn M. Reinhard. "Interfacial hydration determines orientational and functional dimorphism of sterol-derived Raman tags in lipid-coated nanoparticles." Proceedings of the National Academy of Sciences 118, no. 33 (August 13, 2021): e2105913118. http://dx.doi.org/10.1073/pnas.2105913118.

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Lipid-coated noble metal nanoparticles (L-NPs) combine the biomimetic surface properties of a self-assembled lipid membrane with the plasmonic properties of a nanoparticle (NP) core. In this work, we investigate derivatives of cholesterol, which can be found in high concentrations in biological membranes, and other terpenoids, as tunable, synthetic platforms to functionalize L-NPs. Side chains of different length and polarity, with a terminal alkyne group as Raman label, are introduced into cholesterol and betulin frameworks. The synthesized tags are shown to coexist in two conformations in the lipid layer of the L-NPs, identified as “head-out” and “head-in” orientations, whose relative ratio is determined by their interactions with the lipid–water hydrogen-bonding network. The orientational dimorphism of the tags introduces orthogonal functionalities into the NP surface for selective targeting and plasmon-enhanced Raman sensing, which is utilized for the identification and Raman imaging of epidermal growth factor receptor–overexpressing cancer cells.

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Tian, Zhiyuan, Jiangbo Yu, Changfeng Wu, Craig Szymanski, and Jason McNeill. "Amplified energy transfer in conjugated polymer nanoparticle tags and sensors." Nanoscale 2, no. 10 (2010): 1999. http://dx.doi.org/10.1039/c0nr00322k.

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Pregent, Stive, Amir Lichtenstein, Ram Avinery, Adi Laser-Azogui, Fernando Patolsky, and Roy Beck. "Probing the Interactions of Intrinsically Disordered Proteins Using Nanoparticle Tags." Nano Letters 15, no. 5 (April 6, 2015): 3080–87. http://dx.doi.org/10.1021/acs.nanolett.5b00073.

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Huang, Hanbing, Zhuomin Zhang, and Gongke Li. "A Review of Magnetic Nanoparticle-Based Surface-Enhanced Raman Scattering Substrates for Bioanalysis: Morphology, Function and Detection Application." Biosensors 13, no. 1 (December 27, 2022): 30. http://dx.doi.org/10.3390/bios13010030.

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Surface-enhanced Raman scattering (SERS) is a kind of popular non-destructive and water-free interference analytical technology with fast response, excellent sensitivity and specificity to trace biotargets in biological samples. Recently, many researches have focused on the preparation of various magnetic nanoparticle-based SERS substrates for developing efficient bioanalytical methods, which greatly improved the selectivity and accuracy of the proposed SERS bioassays. There has been a rapid increase in the number of reports about magnetic SERS substrates in the past decade, and the number of related papers and citations have exceeded 500 and 2000, respectively. Moreover, most of the papers published since 2009 have been dedicated to analytical applications. In the paper, the recent advances in magnetic nanoparticle-based SERS substrates for bioanalysis were reviewed in detail based on their various morphologies, such as magnetic core–shell nanoparticles, magnetic core–satellite nanoparticles and non-spherical magnetic nanoparticles and their different functions, such as separation and enrichment, recognition and SERS tags. Moreover, the typical application progress on magnetic nanoparticle-based SERS substrates for bioanalysis of amino acids and protein, DNA and RNA sequences, cancer cells and related tumor biomarkers, etc., was summarized and introduced. Finally, the future trends and prospective for SERS bioanalysis by magnetic nanoparticle-based substrates were proposed based on the systematical study of typical and latest references. It is expected that this review would provide useful information and clues for the researchers with interest in SERS bioanalysis.

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Sanchez-Romaguera, Veronica, Sebastian Wünscher, Badredin M. Turki, Robert Abbel, Silvia Barbosa, Daniel J. Tate, Dumtoochukwu Oyeka, et al. "Correction: Inkjet printed paper based frequency selective surfaces and skin mounted RFID tags: the interrelation between silver nanoparticle ink, paper substrate and low temperature sintering technique." Journal of Materials Chemistry C 3, no. 9 (2015): 2141–42. http://dx.doi.org/10.1039/c5tc90035b.

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Correction for ‘Inkjet printed paper based frequency selective surfaces and skin mounted RFID tags: the interrelation between silver nanoparticle ink, paper substrate and low temperature sintering technique' by Veronica Sanchez-Romaguera et al., J. Mater. Chem. C, 2015, DOI: 10.1039/c4tc02693d.

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Indrasekara, A. Swarnapali D. S., Bryan J. Paladini, Dominik J. Naczynski, Valentin Starovoytov, Prabhas V. Moghe, and Laura Fabris. "Dimeric Gold Nanoparticle Assemblies as Tags for SERS-Based Cancer Detection." Advanced Healthcare Materials 2, no. 10 (March 12, 2013): 1370–76. http://dx.doi.org/10.1002/adhm.201200370.

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Choi, Jonghyun, Ian Visagie, Yi Chen, Robert Abbel, and Kate Parker. "NFC-Enabled Dual-Channel Flexible Printed Sensor Tag." Sensors 23, no. 15 (July 28, 2023): 6765. http://dx.doi.org/10.3390/s23156765.

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Wireless sensor tags in flexible formats have numerous applications; some are commercially available for specific target applications. However, most of these wireless sensor tags have been used for single-sensing applications. In this study, we designed a printed circuit board (PCB) module (13 mm × 13 mm) for near-field communication-enabled sensor tags with both electrical resistance and capacitance read-out channels that enables dual-channel sensing. As part of the wireless sensor tag, a square antenna pattern was printed directly on a flexible poly(ethylene terephthalate) (PET) substrate and integrated into the PCB module to demonstrate a dual-channel temperature and ethylene gas sensor. The temperature and ethylene sensors were printed using a positive temperature coefficient ink and a tin oxide (SnO2) nanoparticle ink, respectively. With dual sensing capabilities, this type of sensor tag can be used in smart packaging for the quality monitoring of fresh produce (e.g., bananas) by tracking temperature and ethylene concentration in the storage/transport environment.

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Benešová, Markéta, Silvie Bernatová, Filip Mika, Zuzana Pokorná, Jan Ježek, Martin Šiler, Ota Samek, et al. "SERS-Tags: Selective Immobilization and Detection of Bacteria by Strain-Specific Antibodies and Surface-Enhanced Raman Scattering." Biosensors 13, no. 2 (January 24, 2023): 182. http://dx.doi.org/10.3390/bios13020182.

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Efficient separation and sensitive identification of pathogenic bacterial strains is essential for a prosperous modern society, with direct applications in medical diagnostics, drug discovery, biodefense, and food safety. We developed a fast and reliable method for antibody-based selective immobilization of bacteria from suspension onto a gold-plated glass surface, followed by detection using strain-specific antibodies linked to gold nanoparticles decorated with a reporter molecule. The reporter molecules are subsequently detected by surface-enhanced Raman spectroscopy (SERS). Such a multi-functionalized nanoparticle is called a SERS-tag. The presented procedure uses widely accessible and cheap materials for manufacturing and functionalization of the nanoparticles and the immobilization surfaces. Here, we exemplify the use of the produced SERS-tags for sensitive single-cell detection of opportunistic pathogen Escherichia coli, and we demonstrate the selectivity of our method using two other bacterial strains, Staphylococcus aureus and Serratia marcescens, as negative controls. We believe that the described approach has a potential to inspire the development of novel medical diagnostic tools for rapid identification of bacterial pathogens.

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Wang, S. X., and Guanxiong Li. "Advances in Giant Magnetoresistance Biosensors With Magnetic Nanoparticle Tags: Review and Outlook." IEEE Transactions on Magnetics 44, no. 7 (July 2008): 1687–702. http://dx.doi.org/10.1109/tmag.2008.920962.

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Kim, Jong-Ho, Jun-Sung Kim, Heejeong Choi, Sang-Myung Lee, Bong-Hyun Jun, Kyeong-Nam Yu, Eunye Kuk, et al. "Nanoparticle Probes with Surface Enhanced Raman Spectroscopic Tags for Cellular Cancer Targeting." Analytical Chemistry 78, no. 19 (October 2006): 6967–73. http://dx.doi.org/10.1021/ac0607663.

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Poirot, David, Romain Platel, Thomas Alnasser, François Guerin, Etienne Palleau, and Laurence Ressier. "Smartphone-Identifiable Photoluminescent Nanoparticle-Based Multilevel Secured Tags by Electrical Microcontact Printing." ACS Applied Nano Materials 1, no. 10 (September 26, 2018): 5936–43. http://dx.doi.org/10.1021/acsanm.8b01634.

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MAO, X., J. JIANG, Y. LUO, G. SHEN, and R. YU. "Copper-enhanced gold nanoparticle tags for electrochemical stripping detection of human IgG." Talanta 73, no. 3 (September 30, 2007): 420–24. http://dx.doi.org/10.1016/j.talanta.2007.04.004.

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Wang, Joseph, Guodong Liu, Ronen Polsky, and Arben Merkoçi. "Electrochemical stripping detection of DNA hybridization based on cadmium sulfide nanoparticle tags." Electrochemistry Communications 4, no. 9 (September 2002): 722–26. http://dx.doi.org/10.1016/s1388-2481(02)00434-4.

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Cruz, Bruna, Andreas Albrecht, Philipp Eschlwech, and Erwin Biebl. "Inkjet printing of metal nanoparticles for green UHF RFID tags." Advances in Radio Science 17 (September 19, 2019): 119–27. http://dx.doi.org/10.5194/ars-17-119-2019.

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Abstract. UHF RFID tags are nowadays widely and successfully implemented in many distinct applications, but unfortunately the traditional production process and incorrect disposal of such devices have a negative impact on the environment. In this work silver and gold nanoparticle inks were printed by a consumer inkjet printer on eco-friendly substrates like paper and PET in order to make the manufacturing process less harmful to the ecosystem. A dipole antenna with matching loop was designed for the RFID chip EM4325 from EM Microelectronics, which has an integrated temperature sensor, at the frequency of 866 MHz. Based on this design, simulations of the greener tags are presented and compared as a proof of concept, without optimizing the designs at first for the different materials. The printings with silver (unlike the gold) were conductive with self-sintering. IPL sintering was conducted to reduce the sheet resistance from the silver ink and to turn the gold ink conductive. First S11 parameter and read distance measurements are shown as well as the simulations with the optimized antenna designs.

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Yang, Chih-Tsung, Yi Xu, Mohammad Pourhassan-Moghaddam, Duy Tran, Lin Wu, Xin Zhou, and Benjamin Thierry. "Surface Plasmon Enhanced Light Scattering Biosensing: Size Dependence on the Gold Nanoparticle Tag." Sensors 19, no. 2 (January 15, 2019): 323. http://dx.doi.org/10.3390/s19020323.

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Surface plasmon enhanced light scattering (SP-LS) is a powerful new sensing SPR modality that yields excellent sensitivity in sandwich immunoassay using spherical gold nanoparticle (AuNP) tags. Towards further improving the performance of SP-LS, we systematically investigated the AuNP size effect. Simulation results indicated an AuNP size-dependent scattered power, and predicted the optimized AuNPs sizes (i.e., 100 and 130 nm) that afford extremely high signal enhancement in SP-LS. The maximum scattered power from a 130 nm AuNP is about 1700-fold higher than that obtained from a 17 nm AuNP. Experimentally, a bio-conjugation protocol was developed by coating the AuNPs with mixture of low and high molecular weight PEG molecules. Optimal IgG antibody bioconjugation conditions were identified using physicochemical characterization and a model dot-blot assay. Aggregation prevented the use of the larger AuNPs in SP-LS experiments. As predicted by simulation, AuNPs with diameters of 50 and 64 nm yielded significantly higher SP-LS signal enhancement in comparison to the smaller particles. Finally, we demonstrated the feasibility of a two-step SP-LS protocol based on a gold enhancement step, aimed at enlarging 36 nm AuNPs tags. This study provides a blue-print for the further development of SP-LS biosensing and its translation in the bioanalytical field.

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Wu, Zongyu, Ziwen Wang, Haoqiang Xie, Yiming Wang, Haoqi He, Shuming Nie, Jian Ye, and Li Lin. "Raman-Guided Bronchoscopy: Feasibility and Detection Depth Studies Using Ex Vivo Lung Tissues and SERS Nanoparticle Tags." Photonics 9, no. 6 (June 17, 2022): 429. http://dx.doi.org/10.3390/photonics9060429.

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Image-guided and robotic bronchoscopy is currently under intense research and development for a broad range of clinical applications, especially for minimally invasive biopsy and surgery of peripheral pulmonary nodules or lesions that are frequently discovered by CT or MRI scans. Optical imaging and spectroscopic modalities at the near-infrared (NIR) window hold great promise for bronchoscopic navigation and guidance because of their high detection sensitivity and molecular/cellular specificity. However, light scattering and background interference are two major factors limiting the depth of tissue penetration of photons, and diseased lesions such as small tumors buried under the tissue surface often cannot be detected. Here we report the use of a miniaturized Raman device that is inserted into one of the bronchoscope channels for sensitive detection of “phantom” tumors using fresh pig lung tissues and surface-enhanced Raman scattering (SERS) nanoparticle tags. The ex vivo results demonstrate not only the feasibility of using Raman spectroscopy for endoscopic guidance, but also show that ultrabright SERS nanoparticles allow detection through a bronchial wall of 0.85 mm in thickness and a 5 mm-thick layer of lung tissue (approaching the fourth-generation airway). This work highlights the prospects and potential of Raman-guided bronchoscopy for minimally invasive imaging and detection of lung lesions.

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Qian, Ximei, Xiang-Hong Peng, Dominic O. Ansari, Qiqin Yin-Goen, Georgia Z. Chen, Dong M. Shin, Lily Yang, Andrew N. Young, May D. Wang, and Shuming Nie. "In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags." Nature Biotechnology 26, no. 1 (December 23, 2007): 83–90. http://dx.doi.org/10.1038/nbt1377.

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Sipila, Erja, Johanna Virkki, Lauri Sydanheimo, and Leena Ukkonen. "Experimental Study on Brush-Painted Metallic Nanoparticle UHF RFID Tags on Wood Substrates." IEEE Antennas and Wireless Propagation Letters 14 (2015): 301–4. http://dx.doi.org/10.1109/lawp.2014.2362966.

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Yang, Yanjun, Chunyuan Song, Jingjing Zhang, Jie Chao, Hoang Mai Luong, Yiping Zhao, and Lianhui Wang. "DNA self-assembled Au nanoparticle clusters on silver nanorod arrays for high-sensitive and multiplex detection of cancer-related biomarkers." Nanoscale 14, no. 12 (2022): 4538–47. http://dx.doi.org/10.1039/d2nr00133k.

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A surface-enhanced Raman scattering sensor based on a functionalized multiple-armed tetrahedral DNA nanostructure immobilized silver nanorod array substrate and SERS tags is constructed to achieve both multiplex detection and enhanced sensitivity.

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Popov, Anton, Benediktas Brasiunas, Asta Kausaite-Minkstimiene, and Almira Ramanaviciene. "Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection." Chemosensors 9, no. 4 (April 18, 2021): 85. http://dx.doi.org/10.3390/chemosensors9040085.

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With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed.

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Ballinger, James R. "Challenges in Preparation of Albumin Nanoparticle-Based Radiopharmaceuticals." Molecules 27, no. 23 (December 6, 2022): 8596. http://dx.doi.org/10.3390/molecules27238596.

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Albumin nanocolloids have been used as radiopharmaceuticals for more than 40 years. Their main use is in lymphoscintigraphy and the detection of the sentinel lymph node as part of the surgical treatment of a variety of solid tumours. The main licensed products are labelled with the gamma emitter technetium-99m. Recently, two analogues labelled with positron emitters have been reported, using gallium-68 and zirconium-89. For about 10 years, there has been interest in dual-modal agents with both radioactive and fluorescent labels to improve the localisation of the sentinel lymph node. Indocyanine green (ICG) has been the most widely used fluorescent label, largely due to its availability as a licensed agent and its ease of application. The further development of alternative radiolabels or improved fluorescent tags will require investment in the development and licensing. There is also a vast potential for the targeting of albumin nanocolloids using existing strategies, which could be promising for the development of both diagnostic and therapeutic agents.

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Kim, J. H., J. S. Kim, H. Choi, S. M. Lee, B. H. Jun, K. N. Yu, E. Kuk, et al. "Nanoparticle probes with Surface Enhanced Raman Spectroscopic Tags (SERS Dots) for cellular cancer targeting." Nanomedicine: Nanotechnology, Biology and Medicine 2, no. 4 (December 2006): 317–18. http://dx.doi.org/10.1016/j.nano.2006.10.154.

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Hu, Kongcheng, Ping Liu, Sujuan Ye, and Shusheng Zhang. "Ultrasensitive electrochemical detection of DNA based on PbS nanoparticle tags and nanoporous gold electrode." Biosensors and Bioelectronics 24, no. 10 (June 2009): 3113–19. http://dx.doi.org/10.1016/j.bios.2009.04.001.

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Dojcsák, Dalma, Ágnes Mária Ilosvai, László Vanyorek, Ibolya Gilányi, Csaba Oláh, László Horváth, and Csaba Váradi. "NH2-Functionalized Magnetic Nanoparticles for the N-Glycomic Analysis of Patients with Multiple Sclerosis." International Journal of Molecular Sciences 23, no. 16 (August 13, 2022): 9095. http://dx.doi.org/10.3390/ijms23169095.

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Glycosylation is vital for well-functioning glycoproteins and is reportedly altered in chronic inflammatory disorders, including multiple sclerosis (MS). High-throughput quantitative measurement of protein glycosylation is challenging, as glycans lack fluorophore groups and require fluorescent labeling. The attachment of fluorescent tags to each glycan moiety necessitates sample clean-up for reliable quantitation. The use of magnetic particles in glycan sample preparation is reportedly an easy-to-use solution to accomplish large-scale biomarker discovery studies. In this study, NH2-funtionalized magnetic nanoparticles were synthetized, characterized and applied for the glycosylation analysis of serum samples from patients diagnosed with multiple sclerosis and corresponding healthy controls. Serum samples were PNGase F digested and labeled by procainamide via reductive amination, followed by magnetic nanoparticle-based purification. The prepared samples were analyzed by hydrophilic interaction liquid chromatography, allowing for the relative quantitation of the individual glycan species. Significant glycosylation alterations were detected between MS patients and healthy controls, especially when analyzing the different gender groups.

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Mills, Hilla, Ronald Acquah, Nova Tang, Luke Cheung, Susanne Klenk, Ronald Glassen, Magali Pirson, Alain Albert, Duong Trinh Hoang, and Thang Nguyen Van. "A Critical Scrutiny on Liposomal Nanoparticles Drug Carriers as Modelled by Topotecan Encapsulation and Release in Treating Cancer." Evidence-Based Complementary and Alternative Medicine 2022 (August 9, 2022): 1–7. http://dx.doi.org/10.1155/2022/7702512.

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The medical field is looking for drugs and/or ways of delivering drugs without harming patients. A number of severe drug side effects are reported, such as acute kidney injury (AKI), hepatotoxicity, skin rash, and so on. Nanomedicine has come to the rescue. Liposomal nanoparticles have shown great potential in loading drugs, and delivering drugs to specific targeted sites, hence achieving a needed bioavailability and steady state concentration, which is achieved by a controlled drug release ability by the nanoparticles. The liposomal nanoparticles can be conjugated to cancer receptor tags that give the anticancer-loaded nanoparticles specificity to deliver anticancer agents only at cancerous sites, hence circumventing destruction of normal cells. Also, the particles are biocompatible. The drugs are shielded by attack from the liver and other cytochrome P450 enzymes before reaching the desired sites. The challenge, however, is that the drug release is slow by these nanoparticles on their own. Scientists then came up with several ways to enhance drug release. Magnetic fields, UV light, infrared light, and so on are amongst the enhancers used by scientists to potentiate drug release from nanoparticles. In this paper, synthesis of liposomal nanoparticle formulations (liposomal-quantum dots (L-QDs), liposomal-quantum dots loaded with topotecan (L-QD-TPT)) and their analysis (cytotoxicity, drug internalization, loading efficiency, drug release rate, and the uptake of the drug and nanoparticles by the HeLa cells) are discussed.

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Zolfigol, Mohammad Ali, and Meysam Yarie. "Synthesis and characterization of novel silica-coated magnetic nanoparticles with tags of ionic liquid. Application in the synthesis of polyhydroquinolines." RSC Advances 5, no. 125 (2015): 103617–24. http://dx.doi.org/10.1039/c5ra23670c.

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A novel, green and recoverable silica-coated magnetic nanoparticle immobilized ionic liquid, was designed, synthesized, fully characterized and was used for the synthesis of polyhydroquinoline derivatives.

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Canady, Taylor D., Nantao Li, Lucas D. Smith, Yi Lu, Manish Kohli, Andrew M. Smith, and Brian T. Cunningham. "Digital-resolution detection of microRNA with single-base selectivity by photonic resonator absorption microscopy." Proceedings of the National Academy of Sciences 116, no. 39 (September 9, 2019): 19362–67. http://dx.doi.org/10.1073/pnas.1904770116.

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Circulating exosomal microRNA (miR) represents a new class of blood-based biomarkers for cancer liquid biopsy. The detection of miR at a very low concentration and with single-base discrimination without the need for sophisticated equipment, large volumes, or elaborate sample processing is a challenge. To address this, we present an approach that is highly specific for a target miR sequence and has the ability to provide “digital” resolution of individual target molecules with high signal-to-noise ratio. Gold nanoparticle tags are prepared with thermodynamically optimized nucleic acid toehold probes that, when binding to a target miR sequence, displace a probe-protecting oligonucleotide and reveal a capture sequence that is used to selectively pull down the target-probe–nanoparticle complex to a photonic crystal (PC) biosensor surface. By matching the surface plasmon-resonant wavelength of the nanoparticle tag to the resonant wavelength of the PC nanostructure, the reflected light intensity from the PC is dramatically and locally quenched by the presence of each individual nanoparticle, enabling a form of biosensor microscopy that we call Photonic Resonator Absorption Microscopy (PRAM). Dynamic PRAM imaging of nanoparticle tag capture enables direct 100-aM limit of detection and single-base mismatch selectivity in a 2-h kinetic discrimination assay. The PRAM assay demonstrates that ultrasensitivity (<1 pM) and high selectivity can be achieved on a direct readout diagnostic.

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Shen, Guangyu, and Yun Zhang. "Highly sensitive electrochemical stripping detection of hepatitis B surface antigen based on copper-enhanced gold nanoparticle tags and magnetic nanoparticles." Analytica Chimica Acta 674, no. 1 (July 2010): 27–31. http://dx.doi.org/10.1016/j.aca.2010.06.007.

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Song, Chunyuan, Linghua Min, Ni Zhou, Yanjun Yang, Boyue Yang, Lei Zhang, Shao Su, and Lianhui Wang. "Ultrasensitive detection of carcino-embryonic antigen by using novel flower-like gold nanoparticle SERS tags and SERS-active magnetic nanoparticles." RSC Adv. 4, no. 78 (August 28, 2014): 41666–69. http://dx.doi.org/10.1039/c4ra08402k.

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Ren, Y., J. Virkki, L. Sydänheimo, and L. Ukkonen. "Optimisation of manufacturing parameters for inkjet‐printed and photonically sintered metallic nanoparticle UHF RFID tags." Electronics Letters 50, no. 21 (October 2014): 1504–5. http://dx.doi.org/10.1049/el.2014.2194.

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Bi, Xinyuan, Yuqing Gu, and Jian Ye. "Ag-Coated Au Nanopetals: Dual-Type Single-Nanoparticle Detection of Gap-Enhanced Resonance Raman Tags." ACS Applied Nano Materials 3, no. 7 (June 26, 2020): 6987–95. http://dx.doi.org/10.1021/acsanm.0c01317.

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He, Jing-Lin, Yan-Fei Tian, Zhong Cao, Wei Zou, and Xin Sun. "An electrochemical immunosensor based on gold nanoparticle tags for picomolar detection of c-Myc oncoprotein." Sensors and Actuators B: Chemical 181 (May 2013): 835–41. http://dx.doi.org/10.1016/j.snb.2013.02.063.

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Gu, Wei Bing, and Zheng Cui. "Intense Pulsed Light Sintering of Copper Nanoink for Conductive Copper Film." Applied Mechanics and Materials 748 (April 2015): 187–92. http://dx.doi.org/10.4028/www.scientific.net/amm.748.187.

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Conducting electrodes and films are becoming increasingly important for the printed electronics which can be applied in various fields such as RFID tags, photovoltaics, display and PCB. And copper nanoparticle inks serve as an attractive potential replacement to silver nanoparticle inks because its low cost and good electrical conductivtiy.In this paper, the commercial copper nanoparticle powder with oxide shells were dispersed in the solvent of ethylene glycol. Poly (N-vinylpyrrolidone) (PVP K30) was added to the solvent as capping materials. The prepared copper ink was spin-coated on glass substrate under ambient conduction. Then, the deposited Cu ink was sintered by an intense pulsed light (IPL) system. The sintering effects were investigated with different sintering conditions including pulse energy and pulse duration. The resulting electrical resistivity was 94.1uΩ·cm which is about fifty times as high as that of bulk copper. The high resistivity may be mainly attributed to the porosity of sintered film. Also, crystal phase analysis was performed using x-ray diffraction (XRD) and was found the XRD peaks corresponding to cuprous oxide disappeared after IPL sintering. It was believed that PVP reduced the copper oxide to copper in the process of IPL sintering.

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Song, Yan, Mingyuan Wang, Qin Qian, Jun Xu, Qungang Zhou, Shujie Lv, and Peng Miao. "Trace miRNA Assay Based on DNA Nanostructures Formed by Hybridization Chain Reaction and Gold‐Nanoparticle Tags." ChemElectroChem 8, no. 15 (June 24, 2021): 2778–82. http://dx.doi.org/10.1002/celc.202100466.

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Kawde, Abdel-Nasser, and Joseph Wang. "Amplified Electrical Transduction of DNA Hybridization Based on Polymeric Beads Loaded with Multiple Gold Nanoparticle Tags." Electroanalysis 16, no. 12 (January 2004): 101–7. http://dx.doi.org/10.1002/elan.200302924.

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Hamoy, Fatimah Nasra P., Diana G. Romero, Lea Cristina D. Macaraig, and Erwin P. Enriquez. "Inkjet Printing of UHF RFID Antennas Using Silver and Gold Inks." Key Engineering Materials 913 (March 18, 2022): 35–44. http://dx.doi.org/10.4028/p-5v0h1p.

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Compared with current methods, additive manufacturing processes could offer a more environment-friendly and cost-effective solution in producing long lasting RFID tags for identification and sensing applications. In this work we report the fabrication of UHF RFID antennas by inkjet printing on a flexible substrate. Silver and gold were chosen as ink materials since they are more resistant to weathering than other metals, particularly for applications that require long-term reusability. We compared the print performance of a commercial silver ink and our lab-developed gold nanoparticle (AuNP) ink on polyethylene naphthalate. The printing process for each ink is described using an adopted loop antenna design optimized for 866-868 MHz frequency range. Assembled passive and battery-assisted RFID tags using single-and double-layer sintered, printed antennas coupled with a readable UHF RFID chip showed tolerable detection distances using a commercial compact reader (with short read range specifications). Additionally, we observed a more consistent print behavior and quality, and consequently longer read ranges for the gold antennas (up to 40 cm with battery). Furthermore, the silver antennas oxidized over time resulting in decreased read ranges. Overall, our results show the viability of a printable gold RFID antenna with a tag working range that may be fit for close range non-contact reading.

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Corchero, José Luis, Marianna T. P. Favaro, Merce Márquez-Martínez, Jara Lascorz, Carlos Martínez-Torró, Julieta M. Sánchez, Hèctor López-Laguna, et al. "Recombinant Proteins for Assembling as Nano- and Micro-Scale Materials for Drug Delivery: A Host Comparative Overview." Pharmaceutics 15, no. 4 (April 9, 2023): 1197. http://dx.doi.org/10.3390/pharmaceutics15041197.

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By following simple protein engineering steps, recombinant proteins with promising applications in the field of drug delivery can be assembled in the form of functional materials of increasing complexity, either as nanoparticles or nanoparticle-leaking secretory microparticles. Among the suitable strategies for protein assembly, the use of histidine-rich tags in combination with coordinating divalent cations allows the construction of both categories of material out of pure polypeptide samples. Such molecular crosslinking results in chemically homogeneous protein particles with a defined composition, a fact that offers soft regulatory routes towards clinical applications for nanostructured protein-only drugs or for protein-based drug vehicles. Successes in the fabrication and final performance of these materials are expected, irrespective of the protein source. However, this fact has not yet been fully explored and confirmed. By taking the antigenic RBD domain of the SARS-CoV-2 spike glycoprotein as a model building block, we investigated the production of nanoparticles and secretory microparticles out of the versions of recombinant RBD produced by bacteria (Escherichia coli), insect cells (Sf9), and two different mammalian cell lines (namely HEK 293F and Expi293F). Although both functional nanoparticles and secretory microparticles were effectively generated in all cases, the technological and biological idiosyncrasy of each type of cell factory impacted the biophysical properties of the products. Therefore, the selection of a protein biofabrication platform is not irrelevant but instead is a significant factor in the upstream pipeline of protein assembly into supramolecular, complex, and functional materials.

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Sanchez-Romaguera, Veronica, Mohamed A. Ziai, Dumtoochukwu Oyeka, Silvia Barbosa, Joseph S. R. Wheeler, John C. Batchelor, Edward A. Parker, and Stephen G. Yeates. "Towards inkjet-printed low cost passive UHF RFID skin mounted tattoo paper tags based on silver nanoparticle inks." Journal of Materials Chemistry C 1, no. 39 (2013): 6395. http://dx.doi.org/10.1039/c3tc31302f.

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Alfaawaz, Yasser F., Renad Alamri, Fatimah Almohsen, Sana Shabab, Mai M. Alhamdan, Khold Al Ahdal, Imran Farooq, Fahim Vohra, and Tariq Abduljabbar. "Adhesive Bond Integrity of Experimental Zinc Oxide Nanoparticles Incorporated Dentin Adhesive: An SEM, EDX, μTBS, and Rheometric Analysis." Scanning 2022 (August 10, 2022): 1–9. http://dx.doi.org/10.1155/2022/3477886.

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Objective. Our study is aimed at preparing an experimental adhesive (EA) and assessing the influence of adding 5-10 wt.% concentrations of zinc oxide (ZnO) nanoparticles on the adhesive’s mechanical properties. Methods. Field emission scanning electron microscopy (FESEM) and energy dispersive X-ray (EDX) spectroscopy were employed to investigate the morphology and elemental distribution of the filler nanoparticles. To examine the adhesive properties, microtensile bond strength (μTBS) testing, an investigation of the rheological properties, degree of conversion (DC), and analysis of the interface between the adhesive and dentin were carried out. Results. The SEM micrographs of ZnO nanoparticles demonstrated spherical agglomerates. The EDX plotting confirmed the incidence of Zn and oxygen (O) in the ZnO nanoparticles. The highest μTBS was observed for nonthermocycled (NTC) 5 wt.% ZnO group ( 32.11 ± 3.60 MPa), followed by the NTC-10 wt.% ZnO group ( 30.04 ± 3.24 MPa). Most of the failures observed were adhesive in nature. A gradual reduction in the viscosity was observed at higher angular frequencies, and the addition of 5 and 10 wt.% ZnO to the composition of the EA lowered its viscosity. The 5 wt.% ZnO group demonstrated suitable dentin interaction by showing the formation of resin tags, while for the 10 wt.% ZnO group, compromised resin tag formation was detected. DC was significantly higher in the 0% ZnO (EA) group. Conclusion. The reinforcement of the EA with 5 and 10 wt.% concentrations of ZnO nanoparticles produced an improvement in the adhesive’s μTBS. However, a reduced viscosity was observed for both nanoparticle-reinforced adhesives, and a negotiated dentin interaction was seen for 10 wt.% ZnO adhesive group. Further research exploring the influence of more filler concentrations on diverse adhesive properties is recommended.

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Al-Qahtani, Amal S., Huda I. Tulbah, Mashael Binhasan, Sara Shabib, Khulud A. Al-Aali, Mai M. Alhamdan, and Tariq Abduljabbar. "Influence of Concentration Levels of β-Tricalcium Phosphate on the Physical Properties of a Dental Adhesive." Nanomaterials 12, no. 5 (March 3, 2022): 853. http://dx.doi.org/10.3390/nano12050853.

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Our study assessed the influence of integrating 5% and 10% tricalcium phosphate (β-TCP-Ca3(PO4)2.) nanoparticles into a dental adhesive on the adhesive’s bonding. To evaluate the filler nanoparticles, scanning electron microscopy (SEM), Energy Dispersive X-Ray (EDX) spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, and micro-Raman spectroscopy techniques were used. Shear Bond strength (SBS) testing, degree of conversion (DC) analysis, investigation of the adhesive–dentin interface, and biofilm experiments were conducted. The SEM micrographs revealed non-uniform agglomerates, while the EDX demonstrated the existence of oxygen ‘O’ (24.2%), phosphorus ‘P’ (17.4%) and calcium ‘Ca’ (60.1%) in the β-TCP nanoparticles. The FTIR and micro-Raman spectra indicated characteristic bands for β-TCP containing materials. The 10 wt.% β-TCP adhesive presented the highest SBS values (NTC-10 wt.% β-TCP: 33.55 ± 3.73 MPa, TC-10 wt.% β-TCP: 30.50 ± 3.25 MPa), followed by the 5 wt.% β-TCP adhesive (NTC-5 wt.% β-TCP: 32.37 ± 3.10 MPa, TC-5 wt.% β-TCP: 27.75 ± 3.15 MPa). Most of the detected failures after bond strength testing were adhesive in nature. The β-TCP adhesives demonstrated suitable dentin interaction by forming a hybrid layer (with few or no gaps) and resin tags. The β-TCP adhesives (10 wt.%) revealed lower DC values compared to control. The incorporation of 5 and 10 wt.% concentrations of β-TCP particles resulted in an increase in SBS values. A linear decline in DC values was witnessed when the nanoparticle concentration was increased. Further research focusing on exploring the influence of higher filler concentrations on adhesive’s properties is recommended.

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Cid-Barrio, Laura, Jorge Ruiz Encinar, and José Manuel Costa-Fernández. "Catalytic Gold Deposition for Ultrasensitive Optical Immunosensing of Prostate Specific Antigen." Sensors 20, no. 18 (September 16, 2020): 5287. http://dx.doi.org/10.3390/s20185287.

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A major challenge in the development of bioanalytical methods is to achieve a rapid and robust quantification of disease biomarkers present at very low concentration levels in complex biological samples. An immunoassay platform is presented herein for ultrasensitive and fast detection of the prostate-specific antigen (PSA), a well-recognized cancer biomarker. A sandwich type immunosensor has been developed employing a detection antibody labeled with inorganic nanoparticles acting as tags for further indirect quantification of the analyte. The required high sensitivity is then achieved through a controlled gold deposition on the nanoparticle surface, carried out after completing the recognition step of the immunoassay, thus effectively amplifying the size of the nanoparticles from nm to µm range. Due to such an amplification procedure, quantification of the biomolecule could be carried out directly on the immunoassay plates using confocal microscopy for measurement of the reflected light produced by gold-enlarged nanostructures. The high specificity of the immunoassay was demonstrated with the addition of a major abundant protein in serum (albumin) at much higher concentrations. An extremely low detection limit for PSA quantification (LOD of 1.1 fg·mL−1 PSA) has been achieved. Such excellent LOD is 2–3 orders of magnitude lower than the clinically relevant PSA levels present in biological samples (4–10 ng·mL−1) and even to monitor eventual recurrence after clinical treatment of a prostate tumor (0.1 ng·mL−1). In fact, the broad dynamic range obtained (4 orders of magnitude) would allow the PSA quantification of diverse samples at very different relevant levels.

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Zolfigol, Mohamad Ali, Maliheh Safaiee, and Neda Bahrami-Nejad. "Dendrimeric magnetic nanoparticle cores with Co-phthalocyanine tags and their application in the synthesis of tetrahydrobenzo[b]pyran derivatives." New Journal of Chemistry 40, no. 6 (2016): 5071–79. http://dx.doi.org/10.1039/c6nj00243a.

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Journal articles on the topic 'Nanoparticle tags'

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