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1

Okamoto, Yukihiro, Kaito Hamaguchi, Mayo Watanabe, Nozomi Watanabe, and Hiroshi Umakoshi. "Characterization of Phase Separated Planar Lipid Bilayer Membrane by Fluorescence Ratio Imaging and Scanning Probe Microscope." Membranes 12, no. 8 (2022): 770. http://dx.doi.org/10.3390/membranes12080770.

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The lipid membrane forms nanodomains (rafts) and shows heterogeneous properties. These nanodomains relate to significant roles in various cell functions, and thus the analysis of the nanodomains in phase-separated lipid membranes is important to clarify the function and role of the nanodomains. However, the lipid membrane possesses small-sized nanodomains and shows a small height difference between the nanodomains and their surroundings at certain lipid compositions. In addition, nanodomain analysis sometimes requires highly sensitive and expensive apparatus, such as a two-photon microscope. T
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2

Drab, Mitja, David Stopar, Veronika Kralj-Iglič, and Aleš Iglič. "Inception Mechanisms of Tunneling Nanotubes." Cells 8, no. 6 (2019): 626. http://dx.doi.org/10.3390/cells8060626.

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Tunneling nanotubes (TNTs) are thin membranous tubes that interconnect cells, representing a novel route of cell-to-cell communication and spreading of pathogens. TNTs form between many cell types, yet their inception mechanisms remain elusive. We review in this study general concepts related to the formation and stability of membranous tubular structures with a focus on a deviatoric elasticity model of membrane nanodomains. We review experimental evidence that tubular structures initiate from local membrane bending facilitated by laterally distributed proteins or anisotropic membrane nanodoma
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3

Liang, Pengbo, Thomas F. Stratil, Claudia Popp, et al. "Symbiotic root infections in Medicago truncatula require remorin-mediated receptor stabilization in membrane nanodomains." Proceedings of the National Academy of Sciences 115, no. 20 (2018): 5289–94. http://dx.doi.org/10.1073/pnas.1721868115.

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Plant cell infection is tightly controlled by cell surface receptor-like kinases (RLKs). Like other RLKs, the Medicago truncatula entry receptor LYK3 laterally segregates into membrane nanodomains in a stimulus-dependent manner. Although nanodomain localization arises as a generic feature of plant membrane proteins, the molecular mechanisms underlying such dynamic transitions and their functional relevance have remained poorly understood. Here we demonstrate that actin and the flotillin protein FLOT4 form the primary and indispensable core of a specific nanodomain. Infection-dependent inductio
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4

Kim, Kyou-Hyun, and Jian-Min Zuo. "Convergent-beam electron-diffraction-pattern symmetry of nanodomains in complex lead-based perovskite crystals." Acta Crystallographica Section A Foundations and Advances 70, no. 6 (2014): 583–90. http://dx.doi.org/10.1107/s2053273314013643.

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Convergent-beam electron diffraction (CBED) recorded using nanometre-sized probes, in principle, can detect the highest symmetry in a crystal. However, symmetry reduction may occur by overlapping crystal domains along the beam direction. Thus, delineating the relationship between the recorded and the crystal symmetry is important for studying crystals with complex nanodomains. This paper reports a study of the averaged local symmetry of 71°/109° rhombohedral (R), 90° tetragonal (T) and 180° monoclinic (M) nanodomain structures. The averaged symmetry of nanodomain structures is investigated by
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5

Lipke, Peter N., Caleen Ramsook, Melissa C. Garcia-Sherman, et al. "Between Amyloids and Aggregation Lies a Connection with Strength and Adhesion." New Journal of Science 2014 (February 2, 2014): 1–12. http://dx.doi.org/10.1155/2014/815102.

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We tell of a journey that led to discovery of amyloids formed by yeast cell adhesins and their importance in biofilms and host immunity. We begin with the identification of the adhesin functional amyloid-forming sequences that mediate fiber formation in vitro. Atomic force microscopy and confocal microscopy show 2-dimensional amyloid “nanodomains” on the surface of cells that are activated for adhesion. These nanodomains are arrays of adhesin molecules that bind multivalent ligands with high avidity. Nanodomains form when adhesin molecules are stretched in the AFM or under laminar flow. Treatm
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6

Samhan-Arias, Alejandro K., Joana Poejo, Dorinda Marques-da-Silva, Oscar H. Martínez-Costa, and Carlos Gutierrez-Merino. "Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?" Molecules 28, no. 23 (2023): 7909. http://dx.doi.org/10.3390/molecules28237909.

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Lipid membrane nanodomains or lipid rafts are 10–200 nm diameter size cholesterol- and sphingolipid-enriched domains of the plasma membrane, gathering many proteins with different roles. Isolation and characterization of plasma membrane proteins by differential centrifugation and proteomic studies have revealed a remarkable diversity of proteins in these domains. The limited size of the lipid membrane nanodomain challenges the simple possibility that all of them can coexist within the same lipid membrane domain. As caveolin-1, flotillin isoforms and gangliosides are currently used as neuronal
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7

Fukata, Yuko, Ariane Dimitrov, Gaelle Boncompain, Ole Vielemeyer, Franck Perez, and Masaki Fukata. "Local palmitoylation cycles define activity-regulated postsynaptic subdomains." Journal of Cell Biology 202, no. 1 (2013): 145–61. http://dx.doi.org/10.1083/jcb.201302071.

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Distinct PSD-95 clusters are primary landmarks of postsynaptic densities (PSDs), which are specialized membrane regions for synapses. However, the mechanism that defines the locations of PSD-95 clusters and whether or how they are reorganized inside individual dendritic spines remains controversial. Because palmitoylation regulates PSD-95 membrane targeting, we combined a conformation-specific recombinant antibody against palmitoylated PSD-95 with live-cell super-resolution imaging and discovered subsynaptic nanodomains composed of palmitoylated PSD-95 that serve as elementary units of the PSD
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8

Qiao, Lingxia, Michael Getz, Ben Gross, Brian Tenner, Jin Zhang, and Padmini Rangamani. "Spatiotemporal orchestration of calcium-cAMP oscillations on AKAP/AC nanodomains is governed by an incoherent feedforward loop." PLOS Computational Biology 20, no. 10 (2024): e1012564. http://dx.doi.org/10.1371/journal.pcbi.1012564.

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The nanoscale organization of enzymes associated with the dynamics of second messengers is critical for ensuring compartmentation and localization of signaling molecules in cells. Specifically, the spatiotemporal orchestration of cAMP and Ca2+ oscillations is critical for many cellular functions. Previous experimental studies have shown that the formation of nanodomains of A-kinase anchoring protein 79/150 (AKAP150) and adenylyl cyclase 8 (AC8) on the surface of pancreatic MIN6 β cells modulates the phase of Ca2+-cAMP oscillations from out-of-phase to in-phase. In this work, we develop computa
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9

Dai, Xunhu, Z. Xu, Jie-Fang Li, and Dwight Viehland. "Effects of lanthanum modification on rhombohedral Pb(Zr1−xTix)O3 ceramics: Part II. Relaxor behavior versus enhanced antiferroelectric stability." Journal of Materials Research 11, no. 3 (1996): 626–38. http://dx.doi.org/10.1557/jmr.1996.0076.

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Lanthanum-modified lead zirconate titanate ceramics Pb1−3/2xLax(Zr1−yTiy)O3 [PLZT 100x/100(1 − y)/100y] with Zr/Ti ratios close to the antiferroelectric-ferroelectric (AFE-FE) phase boundary were investigated by dielectric spectroscopy, Sawyer–Tower polarization techniques, and electron microscopy. An incommensurate antiferroelectric (AFEIn) phase was found to be stabilized from the rhombohedral FE state in the compositional series 100x/90/10 for x ≥ 0.02. The La content required to induce the AFEIn state increased as the Ti content was increased. For 100x/85/15, a state with relaxor-like diel
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10

Stelate, Ayoub, Eva Tihlaříková, Kateřina Schwarzerová, Vilém Neděla, and Jan Petrášek. "Correlative Light-Environmental Scanning Electron Microscopy of Plasma Membrane Efflux Carriers of Plant Hormone Auxin." Biomolecules 11, no. 10 (2021): 1407. http://dx.doi.org/10.3390/biom11101407.

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Fluorescence light microscopy provided convincing evidence for the domain organization of plant plasma membrane (PM) proteins. Both peripheral and integral PM proteins show an inhomogeneous distribution within the PM. However, the size of PM nanodomains and protein clusters is too small to accurately determine their dimensions and nano-organization using routine confocal fluorescence microscopy and super-resolution methods. To overcome this limitation, we have developed a novel correlative light electron microscopy method (CLEM) using total internal reflection fluorescence microscopy (TIRFM) a
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11

Huang, Dingquan, Yanbiao Sun, Zhiming Ma, et al. "Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 21274–84. http://dx.doi.org/10.1073/pnas.1911892116.

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Plasmodesmata (PD) are plant-specific membrane-lined channels that create cytoplasmic and membrane continuities between adjacent cells, thereby facilitating cell–cell communication and virus movement. Plant cells have evolved diverse mechanisms to regulate PD plasticity in response to numerous environmental stimuli. In particular, during defense against plant pathogens, the defense hormone, salicylic acid (SA), plays a crucial role in the regulation of PD permeability in a callose-dependent manner. Here, we uncover a mechanism by which plants restrict the spreading of virus and PD cargoes usin
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12

Traeger, Jeremiah, Dehong Hu, Mengran Yang, Gary Stacey, and Galya Orr. "Super-Resolution Imaging of Plant Receptor-Like Kinases Uncovers Their Colocalization and Coordination with Nanometer Resolution." Membranes 13, no. 2 (2023): 142. http://dx.doi.org/10.3390/membranes13020142.

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Plant cell signaling often relies on the cellular organization of receptor-like kinases (RLKs) within membrane nanodomains to enhance signaling specificity and efficiency. Thus, nanometer-scale quantitative analysis of spatial organizations of RLKs could provide new understanding of mechanisms underlying plant responses to environmental stress. Here, we used stochastic optical reconstruction fluorescence microscopy (STORM) to quantify the colocalization of the flagellin-sensitive-2 (FLS2) receptor and the nanodomain marker, remorin, within Arabidopsis thaliana root hair cells. We found that re
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13

Kure, Jakob L., Thommie Karlsson, Camilla B. Andersen, et al. "Using kICS to Reveal Changed Membrane Diffusion of AQP-9 Treated with Drugs." Membranes 11, no. 8 (2021): 568. http://dx.doi.org/10.3390/membranes11080568.

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The formation of nanodomains in the plasma membrane are thought to be part of membrane proteins regulation and signaling. Plasma membrane proteins are often investigated by analyzing the lateral mobility. k-space ICS (kICS) is a powerful image correlation spectroscopy (ICS) technique and a valuable supplement to fluorescence correlation spectroscopy (FCS). Here, we study the diffusion of aquaporin-9 (AQP9) in the plasma membrane, and the effect of different membrane and cytoskeleton affecting drugs, and therefore nanodomain perturbing, using kICS. We measured the diffusion coefficient of AQP9
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14

Ashrafzadeh, Parham, and Ingela Parmryd. "Methods applicable to membrane nanodomain studies?" Essays in Biochemistry 57 (February 6, 2015): 57–68. http://dx.doi.org/10.1042/bse0570057.

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Membrane nanodomains are dynamic liquid entities surrounded by another type of dynamic liquid. Diffusion can take place inside, around and in and out of the domains, and membrane components therefore continuously shift between domains and their surroundings. In the plasma membrane, there is the further complexity of links between membrane lipids and proteins both to the extracellular matrix and to intracellular proteins such as actin filaments. In addition, new membrane components are continuously delivered and old ones removed. On top of this, cells move. Taking all of this into account impos
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15

Atifi, Abderrahman, and Michael D. Ryan. "Voltammetry and Spectroelectrochemistry of TCNQ in Acetonitrile/RTIL Mixtures." Molecules 25, no. 2 (2020): 303. http://dx.doi.org/10.3390/molecules25020303.

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Understanding the solvation and ion-pairing interactions of anionic substrates in room-temperature ionic liquids (RTIL) is key for the electrochemical applications of these new classes of solvents. In this work, cyclic voltammetry and visible and infrared spectroelectrochemistry of tetracyanoquinodimethane (TCNQ) was examined in molecular (acetonitrile) and RTIL solvents, as well as mixtures of these solvents. The overall results were consistent with the formation of RTIL/acetonitrile nanodomains. The voltammetry indicated that the first electrogenerated product, TCNQ−, was not incorporated in
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16

Ouyang, Jun, Xianke Wang, Changtao Shao, Hongbo Cheng, Hanfei Zhu, and Yuhang Ren. "Microstructural Origin of the High-Energy Storage Performance in Epitaxial Lead-Free Ba(Zr0.2Ti0.8)O3 Thick Films." Materials 15, no. 19 (2022): 6778. http://dx.doi.org/10.3390/ma15196778.

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In our previous work, epitaxial Ba(Zr0.2Ti0.8)O3 thick films (~1–2 μm) showed an excellent energy storage performance with a large recyclable energy density (~58 J/cc) and a high energy efficiency (~92%), which was attributed to a nanoscale entangled heterophase polydomain structure. Here, we propose a detailed analysis of the structure–property relationship in these film materials, using an annealing process to illustrate the effect of nanodomain entanglement on the energy storage performance. It is revealed that an annealing-induced stress relaxation led to the segregation of the nanodomains
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17

Vallés, Ana Sofía, and Francisco J. Barrantes. "Nanoscale Sub-Compartmentalization of the Dendritic Spine Compartment." Biomolecules 11, no. 11 (2021): 1697. http://dx.doi.org/10.3390/biom11111697.

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Compartmentalization of the membrane is essential for cells to perform highly specific tasks and spatially constrained biochemical functions in topographically defined areas. These membrane lateral heterogeneities range from nanoscopic dimensions, often involving only a few molecular constituents, to micron-sized mesoscopic domains resulting from the coalescence of nanodomains. Short-lived domains lasting for a few milliseconds coexist with more stable platforms lasting from minutes to days. This panoply of lateral domains subserves the great variety of demands of cell physiology, particularly
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18

Welberry, T. R., and D. J. Goossens. "Different models for the polar nanodomain structure of PZN and other relaxor ferroelectrics." Journal of Applied Crystallography 41, no. 3 (2008): 606–14. http://dx.doi.org/10.1107/s0021889808012491.

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Computer simulations have been carried out to test the recently proposed model for the nanodomain structure of relaxor ferroelectrics such as lead zinc niobate (PZN). In this recent model it was supposed that the polar nanodomains are three-dimensional, that the observed diffuse rods of scattering originate from the boundaries between domains and that the Pb displacements may be directed along \langle {100} \rangle, \langle {111} \rangle or \langle {110} \rangle. This is in marked contrast to a previously published model, which described the polar domains as thin plates with Pb displacements c
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19

Ingrole, Rohan S., Wenqian Tao, Jatindra N. Tripathy, and Harvinder S. Gill. "Synthesis and Immunogenicity Assessment of Elastin-Like Polypeptide-M2e Construct as an Influenza Antigen." Nano LIFE 04, no. 02 (2014): 1450004. http://dx.doi.org/10.1142/s1793984414500044.

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The 23 amino acid-long extracellular domain of the influenza virus transmembrane protein M2 (M2e) has remained highly conserved since the 1918 pandemic, and is thus considered a good candidate for development of a universal influenza A vaccine. However, M2e is poorly immunogenic. In this study we assessed the potential of increasing immunogenicity of M2e by constructing a nanoscale-designed protein polymer containing the M2e sequence and an elastin-like polypeptide (ELP) nanodomain consisting of alanine and tyrosine guest residues (ELP(A2YA2)24). The ELP nanodomain was included to increase ant
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20

Glöckner, Nina, Sven zur Oven-Krockhaus, Leander Rohr, et al. "Three-Fluorophore FRET Enables the Analysis of Ternary Protein Association in Living Plant Cells." Plants 11, no. 19 (2022): 2630. http://dx.doi.org/10.3390/plants11192630.

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Protein-protein interaction studies provide valuable insights into cellular signaling. Brassinosteroid (BR) signaling is initiated by the hormone-binding receptor Brassinosteroid Insensitive 1 (BRI1) and its co-receptor BRI1 Associated Kinase 1 (BAK1). BRI1 and BAK1 were shown to interact independently with the Receptor-Like Protein 44 (RLP44), which is implicated in BRI1/BAK1-dependent cell wall integrity perception. To demonstrate the proposed complex formation of BRI1, BAK1 and RLP44, we established three-fluorophore intensity-based spectral Förster resonance energy transfer (FRET) and FRET
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21

Schneider, Falk, Dominic Waithe, Mathias P. Clausen, et al. "Diffusion of lipids and GPI-anchored proteins in actin-free plasma membrane vesicles measured by STED-FCS." Molecular Biology of the Cell 28, no. 11 (2017): 1507–18. http://dx.doi.org/10.1091/mbc.e16-07-0536.

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Diffusion and interaction dynamics of molecules at the plasma membrane play an important role in cellular signaling and are suggested to be strongly associated with the actin cytoskeleton. Here we use superresolution STED microscopy combined with fluorescence correlation spectroscopy (STED-FCS) to access and compare the diffusion characteristics of fluorescent lipid analogues and GPI-anchored proteins (GPI-APs) in the live-cell plasma membrane and in actin cytoskeleton–free, cell-derived giant plasma membrane vesicles (GPMVs). Hindered diffusion of phospholipids and sphingolipids is abolished
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22

Nakagawa, Shintaro, Yuki Yoneguchi, Takashi Ishizone, Shuichi Nojima, Kazuo Yamaguchi та Seiichi Nakahama. "Crystal orientation of poly(ε-caprolactone) chains confined in lamellar nanodomains: Effects of chain-ends tethering to nanodomain interfaces". Polymer 112 (березень 2017): 116–24. http://dx.doi.org/10.1016/j.polymer.2017.01.075.

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23

Chao, Ying-Chi, Nicoletta C. Surdo, Sergio Pantano, and Manuela Zaccolo. "Imaging cAMP nanodomains in the heart." Biochemical Society Transactions 47, no. 5 (2019): 1383–92. http://dx.doi.org/10.1042/bst20190245.

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Abstract 3′-5′-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger that modulates multiple cellular functions. It is now well established that cAMP can mediate a plethora of functional effects via a complex system of local regulatory mechanisms that result in compartmentalized signalling. The use of fluorescent probes to monitor cAMP in intact, living cells have been instrumental in furthering our appreciation of this ancestral and ubiquitous pathway and unexpected details of the nano-architecture of the cAMP signalling network are starting to emerge. Recent evidence shows t
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24

Tortajada, Marta. "Interconnected mesopores and high accessibility in UVM-7-like silicas." Journal of Nanoparticle Research 14, no. 8 (2012): 1045. https://doi.org/10.5281/zenodo.14774211.

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The research investigates the pore architecture of UVM-7-like silicas, revealing a hierarchical connectivity of inter- and intra-nanoparticle pores that enhances mass-transfer kinetics. This structure facilitates efficient processes such as gold nanodomain mobility and enzyme adsorption, demonstrating the advantages of nanoparticulated bimodal mesoporous silicas in various applications. Nanoparticulated bimodal mesoporous silicas (NBS) have proved to constitute adequate supports in a variety of applications requiring enhanced accessibility to the active sites. Mass-transfer kinetics seems to b
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25

Zhong, Liyun, Zhun Zhang, Xiaoxu Lu, Shengde Liu, Crystal Y. Chen, and Zheng W. Chen. "NSOM/QD-Based Visualization of GM1 Serving as Platforms for TCR/CD3 Mediated T-Cell Activation." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/276498.

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Direct molecular imaging of nanoscale relationship between T-cell receptor complexes (TCR/CD3) and gangliosidosis GM1 before and after T-cell activation has not been reported. In this study, we made use of our expertise of near-field scanning optical microscopy(NSOM)/immune-labeling quantum dots- (QD-)based dual-color imaging system to visualize nanoscale profiles for distribution and organization of TCR/CD3, GM1, as well as their nanospatial relationship and their correlation with PKCθsignaling cascade during T-cell activation. Interestingly, after anti-CD3/anti-CD28 Ab co-stimulation, both T
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26

Silvius, John R. "Membrane Nanodomains." Colloquium Series on Building Blocks of the Cell: Cell Structure and Function 1, no. 1 (2013): 1–103. http://dx.doi.org/10.4199/c00076ed1v01y201303bbc001.

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Kar, Pulak, Yu-Ping Lin, Rajesh Bhardwaj, et al. "The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry." Proceedings of the National Academy of Sciences 118, no. 19 (2021): e2012908118. http://dx.doi.org/10.1073/pnas.2012908118.

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To avoid conflicting and deleterious outcomes, eukaryotic cells often confine second messengers to spatially restricted subcompartments. The smallest signaling unit is the Ca2+ nanodomain, which forms when Ca2+ channels open. Ca2+ nanodomains arising from store-operated Orai1 Ca2+ channels stimulate the protein phosphatase calcineurin to activate the transcription factor nuclear factor of activated T cells (NFAT). Here, we show that NFAT1 tethered directly to the scaffolding protein AKAP79 (A-kinase anchoring protein 79) is activated by local Ca2+ entry, providing a mechanism to selectively re
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Koklič, Tilen, Alenka Hrovat, Ramon Guixà-González, et al. "Electron Paramagnetic Resonance Gives Evidence for the Presence of Type 1 Gonadotropin-Releasing Hormone Receptor (GnRH-R) in Subdomains of Lipid Rafts." Molecules 26, no. 4 (2021): 973. http://dx.doi.org/10.3390/molecules26040973.

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This study investigated the effect of type 1 gonadotropin releasing hormone receptor (GnRH-R) localization within lipid rafts on the properties of plasma membrane (PM) nanodomain structure. Confocal microscopy revealed colocalization of PM-localized GnRH-R with GM1-enriched raft-like PM subdomains. Electron paramagnetic resonance spectroscopy (EPR) of a membrane-partitioned spin probe was then used to study PM fluidity of immortalized pituitary gonadotrope cell line αT3-1 and HEK-293 cells stably expressing GnRH-R and compared it with their corresponding controls (αT4 and HEK-293 cells). Compu
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Kang, Xinchen, Xiaoxue Ma, Jianling Zhang, et al. "Formation of large nanodomains in liquid solutions near the phase boundary." Chemical Communications 52, no. 99 (2016): 14286–89. http://dx.doi.org/10.1039/c6cc08015d.

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Mesarec, Luka, Mitja Drab, Samo Penič, Veronika Kralj-Iglič, and Aleš Iglič. "On the Role of Curved Membrane Nanodomains and Passive and Active Skeleton Forces in the Determination of Cell Shape and Membrane Budding." International Journal of Molecular Sciences 22, no. 5 (2021): 2348. http://dx.doi.org/10.3390/ijms22052348.

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Biological membranes are composed of isotropic and anisotropic curved nanodomains. Anisotropic membrane components, such as Bin/Amphiphysin/Rvs (BAR) superfamily protein domains, could trigger/facilitate the growth of membrane tubular protrusions, while isotropic curved nanodomains may induce undulated (necklace-like) membrane protrusions. We review the role of isotropic and anisotropic membrane nanodomains in stability of tubular and undulated membrane structures generated or stabilized by cyto- or membrane-skeleton. We also describe the theory of spontaneous self-assembly of isotropic curved
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Cebecauer, Marek, Mariana Amaro, Piotr Jurkiewicz, et al. "Membrane Lipid Nanodomains." Chemical Reviews 118, no. 23 (2018): 11259–97. http://dx.doi.org/10.1021/acs.chemrev.8b00322.

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32

Timofeeva, Ekaterina E., Elena Yu Panchenko, Maria V. Zherdeva, et al. "The Effect of Thermal Treatment on Microstructure and Thermal-Induced Martensitic Transformations in Ni44Fe19Ga27Co10 Single Crystals." Metals 12, no. 11 (2022): 1960. http://dx.doi.org/10.3390/met12111960.

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Heat treatments of single crystals of Ni44Fe19Ga27Co10 (at.%) shape memory alloys cause various microstructures of the high-temperature phase. The nanodomain structure, consisting of regions of the L21- and B2-phases, and nanosized particles are the main parameters that change during heat treatments and determine the mechanism of nucleation and growth of martensite crystals, the size of thermal-induced martensite lamellae, the temperature Ms, and the temperature intervals of the martensitic transformation. In the as-grown single crystals, the high-temperature phase has only the L21-structure a
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Kedia, Shekhar, Pratyush Ramakrishna, Pallavi Rao Netrakanti, et al. "Real-time nanoscale organization of amyloid precursor protein." Nanoscale 12, no. 15 (2020): 8200–8215. http://dx.doi.org/10.1039/d0nr00052c.

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Regulatory nanodomains modulated by lateral diffusion control transient equilibrium between pools of APP within an excitatory synapse. Molecular fingerprints of these nanodomains are altered in variants of APP implicated in Alzheimer's Disease.
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Karbalaei Akbari, Mohammad, Nasrin Siraj Lopa, Jihae Park, and Serge Zhuiykov. "Plasmonic Nanodomains Decorated on Two-Dimensional Oxide Semiconductors for Photonic-Assisted CO2 Conversion." Materials 16, no. 10 (2023): 3675. http://dx.doi.org/10.3390/ma16103675.

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Plasmonic nanostructures ensure the reception and harvesting of visible lights for novel photonic applications. In this area, plasmonic crystalline nanodomains decorated on the surface of two-dimensional (2D) semiconductor materials represent a new class of hybrid nanostructures. These plasmonic nanodomains activate supplementary mechanisms at material heterointerfaces, enabling the transfer of photogenerated charge carriers from plasmonic antennae into adjacent 2D semiconductors and therefore activate a wide range of visible-light assisted applications. Here, the controlled growth of crystall
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35

Kundu, Asish K., Oleg I. Lebedev, Nadezhda E. Volkova та ін. "Quintuple perovskites Ln2Ba3Fe5−xCoxO15−δ(Ln = Sm, Eu): nanoscale ordering and unconventional magnetism". Journal of Materials Chemistry C 3, № 21 (2015): 5398–405. http://dx.doi.org/10.1039/c5tc00494b.

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Perovskite Sm<sub>2</sub>Ba<sub>3</sub>Fe<sub>3</sub>Co<sub>2</sub>O<sub>14.07</sub>consists of 90° chemically twinned nanodomains with five-fold periodicity and exhibits short range AFM interactions within the nanodomains.
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Kudryashov, Sergey, Alexey Rupasov, Mikhail Kosobokov, et al. "Ferroelectric Nanodomain Engineering in Bulk Lithium Niobate Crystals in Ultrashort-Pulse Laser Nanopatterning Regime." Nanomaterials 12, no. 23 (2022): 4147. http://dx.doi.org/10.3390/nano12234147.

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Ferroelectric nanodomains were formed in bulk lithium niobate single crystals near nanostructured microtracks laser-inscribed by 1030-nm 0.3-ps ultrashort laser pulses at variable pulse energies in sub- and weakly filamentary laser nanopatterning regimes. The microtracks and related nanodomains were characterized by optical, scanning probe and confocal second-harmonic generation microscopy methods. The nanoscale material sub-structure in the microtracks was visualized in the sample cross-sections by atomic force microscopy (AFM), appearing weakly birefringent in polarimetric microscope images.
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Li, Guangtao, Qing Wang, Shinako Kakuda, and Erwin London. "Nanodomains can persist at physiologic temperature in plasma membrane vesicles and be modulated by altering cell lipids." Journal of Lipid Research 61, no. 5 (2020): 758–66. http://dx.doi.org/10.1194/jlr.ra119000565.

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The formation and properties of liquid-ordered (Lo) lipid domains (rafts) in the plasma membrane are still poorly understood. This limits our ability to manipulate ordered lipid domain-dependent biological functions. Giant plasma membrane vesicles (GPMVs) undergo large-scale phase separations into coexisting Lo and liquid-disordered lipid domains. However, large-scale phase separation in GPMVs detected by light microscopy is observed only at low temperatures. Comparing Förster resonance energy transfer-detected versus light microscopy-detected domain formation, we found that nanodomains, domai
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Karbalaei Akbari, Mohammad, Nasrin Siraj Lopa, and Serge Zhuiykov. "Crystalline Nanodomains at Multifunctional Two-Dimensional Liquid–Metal Hybrid Interfaces." Crystals 13, no. 4 (2023): 604. http://dx.doi.org/10.3390/cryst13040604.

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Two-dimensional (2D) liquid–metal (LM) heterointerfaces with their tunable physicochemical characteristics are emerging platforms for the development of multifunctional hybrid nanostructures with numerous functional applications. From this perspective, the functionalization of LM galinstan nanoparticles (NPs) with crystalline nanodomains is a promising approach toward the synthesis of novel 2D hybrid LM heterointerfaces with unprecedented properties. However, the decoration of LM heterointerfaces with desired nanocrystalline structures is a challenging process due to simultaneous and intensive
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39

Shur, V. Ya, V. A. Shikhova, P. S. Zelenovskiy, D. V. Pelegov, L. I. Ivleva, and J. Dec. "Formation of self-assembled nanodomain structures in single crystals of uniaxial ferroelectrics lithium niobate, lithium tantalate and strontium–barium niobate." Journal of Advanced Dielectrics 04, no. 01 (2014): 1450006. http://dx.doi.org/10.1142/s2010135x14500064.

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The formation and evolution of the self-assembled nanodomain structures during polarization reversal have been comparatively analyzed in single crystals of various uniaxial ferroelectrics: LiNbO 3 (LN), LiTaO 3 (LT) and Sr x Ba 1-x Nb 2 O 6 (SBN). Several experimental methods have been used for visualization of the micro- and nanodomain patterns. The static domain images have been obtained by optical microscopy and piezoresponse force microscopy. The Raman confocal microscopy allowed us to obtain the domain images in the bulk. The equilibrium slow switching with effective screening resulted in
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Hajnoczky, György. "Cellular hydrogen peroxide nanodomains." Free Radical Biology and Medicine 165 (March 2021): 14. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.282.

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41

Ma, Yuanqing, Elizabeth Hinde, and Katharina Gaus. "Nanodomains in biological membranes." Essays in Biochemistry 57 (February 6, 2015): 93–107. http://dx.doi.org/10.1042/bse0570093.

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Lipid rafts are defined as cholesterol- and sphingomyelin-enriched membrane domains in the plasma membrane of cells that are highly dynamic and cannot be resolved with conventional light microscopy. Membrane proteins that are embedded in the phospholipid matrix can be grouped into raft and non-raft proteins based on their association with detergent-resistant membranes in biochemical assays. Selective lipid–protein interactions not only produce heterogeneity in the membrane, but also cause the spatial compartmentalization of membrane reactions. It has been proposed that lipid rafts function as
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Jackson, Peter K. "cAMP Signaling in Nanodomains." Cell 182, no. 6 (2020): 1379–81. http://dx.doi.org/10.1016/j.cell.2020.08.041.

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43

Scott, J. F., A. Gruverman, D. Wu, I. Vrejoiu, and M. Alexe. "Nanodomain faceting in ferroelectrics." Journal of Physics: Condensed Matter 20, no. 42 (2008): 425222. http://dx.doi.org/10.1088/0953-8984/20/42/425222.

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44

Gan, Kefu, and Zhiming Li. "Unveiling the role of glassy nanodomains in strength and plasticity of crystal–glass nanocomposites via atomistic simulation." Journal of Applied Physics 131, no. 8 (2022): 085109. http://dx.doi.org/10.1063/5.0080746.

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Crystalline metals and alloys are usually ductile owing to lattice dislocations and various slip systems, while bulk metallic glasses show ultrahigh yield strength with very limited plasticity. Combining the crystalline and glassy phases in one alloy has recently been shown to be promising for achieving both ultrahigh strength and good deformability. Yet, it is challenging to capture the dynamic dislocation behavior through the deformation process and elucidate the role of glassy domains on the excellent mechanical performance of the nanocomposites. Here, we unveil and visualize the atomic-sca
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Zhao, Zunqiang, Shu Deng, Zhongwei Lv, and Jianshe Yang. "Cellular Innate Biological Nano Confinements Control Cancer Metastasis Through Materials Seizing and Signaling Regulating." Technology in Cancer Research & Treatment 22 (January 2023): 153303382311589. http://dx.doi.org/10.1177/15330338231158917.

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Cancer is a debilitating disease, causing millions of deaths annually throughout the world. Due to their adaptive ability to meet nutritional demands, cancer cells often utilize more energy than normal cells. In order to develop new strategies to treat cancer, it is necessary to understand the underlying mechanisms of energy metabolism, which is yet largely unknown. Recent studies have shown that cellular innate nanodomains are involved in cellular energy metabolism and anabolism and GPCRs signaling regulation, which have a direct effect on cell fate and functions. Therefore, harnessing cellul
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Castells-Garcia, Alvaro, Ilyas Ed-daoui, Esther González-Almela, et al. "Super resolution microscopy reveals how elongating RNA polymerase II and nascent RNA interact with nucleosome clutches." Nucleic Acids Research 50, no. 1 (2021): 175–90. http://dx.doi.org/10.1093/nar/gkab1215.

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Abstract Transcription and genome architecture are interdependent, but it is still unclear how nucleosomes in the chromatin fiber interact with nascent RNA, and which is the relative nuclear distribution of these RNAs and elongating RNA polymerase II (RNAP II). Using super-resolution (SR) microscopy, we visualized the nascent transcriptome, in both nucleoplasm and nucleolus, with nanoscale resolution. We found that nascent RNAs organize in structures we termed RNA nanodomains, whose characteristics are independent of the number of transcripts produced over time. Dual-color SR imaging of nascen
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Arcos Casarrubias, JA, A. Reyes-Mayer, R. Guardian-Tapia, P. Castillo-Ocampo, and A. Romo-Uribe. "Rubber Nanodomains Reinforced Epoxy Resin." MRS Advances 1, no. 21 (2016): 1571–76. http://dx.doi.org/10.1557/adv.2016.297.

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ABSTRACTIt has been reported that the addition of liquid rubbers, like poly(dimethylsiloxane) (PDMS), to epoxy resins alter the final morphology, increase the toughness and influence the curing kinetics. Due to immiscibility, there is phase separation of the elastomeric phase during curing giving rise to microdomains embedded in the epoxic matrix. The resultant heterogeneous morphology obtained after the reaction controls to an important extent the properties of the epoxy composite. Here we report a method to obtain well-dispersed rubber nanodomains of silyl-diglycidyl ether terminated polydim
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Chen, Hong, Giuseppe R. Palmese, and Yossef A. Elabd. "Membranes with Oriented Polyelectrolyte Nanodomains." Chemistry of Materials 18, no. 20 (2006): 4875–81. http://dx.doi.org/10.1021/cm061422w.

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Ivanova, S. V. "Nanodomain structures in nonlinear crystal." Ferroelectrics 539, no. 1 (2019): 9–15. http://dx.doi.org/10.1080/00150193.2019.1570005.

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Berger, Mareike, Manoel Manghi, and Nicolas Destainville. "Nanodomains in Biomembranes with Recycling." Journal of Physical Chemistry B 120, no. 40 (2016): 10588–602. http://dx.doi.org/10.1021/acs.jpcb.6b07631.

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