Journal articles: 'Nano-Theranostics'

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Liu, Zhuang, and Xing-Jie Liang. "Nano-Carbons as Theranostics." Theranostics 2, no. 3 (2012): 235–37. http://dx.doi.org/10.7150/thno.4156.

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Yoon, Juyoung. "Theranostics based nano probes and nano carriers." Coordination Chemistry Reviews 415 (July 2020): 213297. http://dx.doi.org/10.1016/j.ccr.2020.213297.

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Sharmiladevi, Palani, Koyeli Girigoswami, Viswanathan Haribabu, and Agnishwar Girigoswami. "Nano-enabled theranostics for cancer." Materials Advances 2, no. 9 (2021): 2876–91. http://dx.doi.org/10.1039/d1ma00069a.

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The review highlights the nanotheranostic agents prove to be highly efficient in generating theragnosis overcoming the deficiencies noted with conventional diagnostic and therapeutic agents used for cancers.

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Kalita, Himani, and Manoj Patowary. "Biocompatible Polymer Nano-Constructs: A Potent Platform for Cancer Theranostics." Technology in Cancer Research & Treatment 22 (January 2023): 153303382311603. http://dx.doi.org/10.1177/15330338231160391.

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Nano-constructs of biocompatible polymers have drawn wide attention owing to their potential as theranostics for simultaneous therapy and detection of cancer. The present mini review summarizes various nano-architectures of polymers that have been developed as theranostic agents for the simultaneous treatment and diagnosis of cancer in a single platform. Additionally, research prospects of polymeric cancer theranostics for the future have been highlighted.

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Lee, Songyi, Thanh Chung Pham, Chaeeon Bae, Yeonghwan Choi, Yong Kyun Kim, and Juyoung Yoon. "Nano theranostics platforms that utilize proteins." Coordination Chemistry Reviews 412 (June 2020): 213258. http://dx.doi.org/10.1016/j.ccr.2020.213258.

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Wang, Yong-Mei, Ying Xu, Xinxin Zhang, Yifan Cui, Qingquan Liang, Cunshun Liu, Xinan Wang, Shuqi Wu, and Rusen Yang. "Single Nano-Sized Metal–Organic Framework for Bio-Nanoarchitectonics with In Vivo Fluorescence Imaging and Chemo-Photodynamic Therapy." Nanomaterials 12, no. 2 (January 17, 2022): 287. http://dx.doi.org/10.3390/nano12020287.

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Theranostics is an emerging technique for cancer treatments due to its safety and high efficiency. However, the stability, efficiency, and convenience of preparation are the main challenges for developing theranostics. Here we describe a one-pot process for biocompatible metal–organic framework (MOF)-based theranostics. The ligand H2L designed for the MOF enables both red fluorescence emission and photodynamic therapy (PDT). The frame and regular channel structure of H2L-MOF empower the theranostics with good drug delivery performance, and the uniform and nano-sized particles facilitate the in vivo imaging/therapy applications. In vivo fluorescence imaging and in vitro chemo-photodynamic therapy were achieved with the MOF without any further modification. Our results reveal an effective strategy to achieve multifunctional theranostics by the synergistic action of the organic ligand, metal node, and channel structure of MOF nanoparticles.

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Sneider, Alexandra, Derek VanDyke, Shailee Paliwal, and Prakash Rai. "Remotely Triggered Nano-Theranostics For Cancer Applications." Nanotheranostics 1, no. 1 (2017): 1–22. http://dx.doi.org/10.7150/ntno.17109.

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Yao, Jingwen, Chao-Hsiung Hsu, Zhao Li, Tanya Kim, Lian-Pin Hwang, Ying-Chih Lin, and Yung-Ya Lin. "Magnetic Resonance Nano-Theranostics for Glioblastoma Multiforme." Current Pharmaceutical Design 21, no. 36 (November 2, 2015): 5256–66. http://dx.doi.org/10.2174/1381612821666150923103307.

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Mousavi, Hajar, Behrooz Movahedi, Ali Zarrabi, and Marzieh Jahandar. "A multifunctional hierarchically assembled magnetic nanostructure towards cancer nano-theranostics." RSC Advances 5, no. 94 (2015): 77255–63. http://dx.doi.org/10.1039/c5ra16776k.

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Dai, Yan-Dong, Xue-Yi Sun, Wan Sun, Jing-Bo Yang, Rui Liu, Yi Luo, Tao Zhang, Yu Tian, Zhong-Lin Lu, and Lan He. "H2O2-responsive polymeric micelles with a benzil moiety for efficient DOX delivery and AIE imaging." Organic & Biomolecular Chemistry 17, no. 22 (2019): 5570–77. http://dx.doi.org/10.1039/c9ob00859d.

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Qian, Chengyuan, Chengyi Yuan, Changhong Li, Hao Liu, and Xiaohui Wang. "Multifunctional nano-enabled delivery systems in Alzheimer's disease management." Biomaterials Science 8, no. 20 (2020): 5538–54. http://dx.doi.org/10.1039/d0bm00756k.

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This review discusses the recent advances in multifunctional nano-enabled delivery systems (NDS) for Alzheimer's disease management, including multitherapeutics, multimodal imaging-guided diagnostics, and theranostics.

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Sailaja Gunnam, Sharat Chandrika Sandru, Monika Nijhawan, and Rajeswari Aleti. "Nano-theranostics: A novel platform in drug therapy." World Journal of Advanced Research and Reviews 23, no. 3 (September 30, 2024): 1706–16. http://dx.doi.org/10.30574/wjarr.2024.23.3.2799.

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A fundamental component of customized medicine, theranostics is a therapy approach that combines therapeutics and diagnostics with the goal of increasing drug efficacy and safety while also monitoring treatment response. It will require significant advancements in predictive medicine. Theranostics is linked to tailored drug administration based on test results as well as a diagnostic that screens patients for potential adverse drug reactions. Early diagnosis and treatment have benefited from the designed nanoparticles with unique physicochemical characteristics. This allows treatments to be delivered and the detection method to be employed concurrently, not just before or after treatment but throughout the entire regimen. The development of nanotechnology presents more opportunities for theranostics applications using nanoparticle engineering, and it has demonstrated encouraging outcomes, particularly in cancer therapy when compared with conventional treatments.

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SL, Prabu. "Nano based Drug Delivery System for Cancer Therapy: A Next Generation Theranostics." Bioequivalence & Bioavailability International Journal 6, no. 2 (July 15, 2022): 1–17. http://dx.doi.org/10.23880/beba-16000178.

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Cancer is considered as one of the foremost cause of illness and death with very complex pathophysiology even though prominent advancement has been made on innovative tumor treatments. Therapeutic properties and the global survival rate are still disappointing for the patients with cancer. There is a shortfall in the capabilities of these cancer therapies, some novel strategies are developed to provide better treatment therapies to improve their quality of life and also aids in reducing the number of deaths. Amongst the cardinal phases towards ensuring ideal cancer management is early diagnosis and targeted drug delivery of anti-tumor to decrease its toxicities. Recently the progress of nanotechnology as novel therapeutics, have advanced and trialed to overwhelm numerous limitations of previously available drug delivery systems for cancer treatment. Nanobased therapeutics has provided the chance to directly contact the tumorous cells selectively with improved drug localization, cellular application as well as providing targeted drug delivery eluding the interaction with the healthy cells. In this review, we summarize about various novel nanomaterials as anti-tumour drug delivery carriers for cancer treatment; also provide insight into the superlative necessities of nanotechnology in cancer therapy and its challenges in targeted drug delivery

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Pala, Rajasekharreddy, Subhaswaraj Pattnaik, Siddhardha Busi, and Surya M. Nauli. "Nanomaterials as Novel Cardiovascular Theranostics." Pharmaceutics 13, no. 3 (March 7, 2021): 348. http://dx.doi.org/10.3390/pharmaceutics13030348.

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Cardiovascular diseases (CVDs) are a group of conditions associated with heart and blood vessels and are considered the leading cause of death globally. Coronary heart disease, atherosclerosis, myocardial infarction represents the CVDs. Since CVDs are associated with a series of pathophysiological conditions with an alarming mortality and morbidity rate, early diagnosis and appropriate therapeutic approaches are critical for saving patients’ lives. Conventionally, diagnostic tools are employed to detect disease conditions, whereas therapeutic drug candidates are administered to mitigate diseases. However, the advent of nanotechnological platforms has revolutionized the current understanding of pathophysiology and therapeutic measures. The concept of combinatorial therapy using both diagnosis and therapeutics through a single platform is known as theranostics. Nano-based theranostics are widely used in cancer detection and treatment, as evident from pre-clinical and clinical studies. Nanotheranostics have gained considerable attention for the efficient management of CVDs. The differential physicochemical properties of engineered nanoparticles have been exploited for early diagnosis and therapy of atherosclerosis, myocardial infarction and aneurysms. Herein, we provided the information on the evolution of nano-based theranostics to detect and treat CVDs such as atherosclerosis, myocardial infarction, and angiogenesis. The review also aims to provide novel avenues on how nanotherapeutics’ trending concept could transform our conventional diagnostic and therapeutic tools in the near future.

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Thorat, Nanasaheb D., Raghvendra A. Bohara, Hemraj M. Yadav, and Syed A. M. Tofail. "Multi-modal MR imaging and magnetic hyperthermia study of Gd doped Fe3O4 nanoparticles for integrative cancer therapy." RSC Advances 6, no. 97 (2016): 94967–75. http://dx.doi.org/10.1039/c6ra20135k.

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Gadolinium (Gd) doped iron oxide nano-mediator in cancer theranostics are one of the most promising candidates in combining diagnostics (imaging) and therapeutics (molecular therapy) functions in a single, multimodal platform.

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Aoki, Ichio, Jun-ichiro Jo, Horacio Cabral, Rumiana Bakalova, and Kevin M. Bennett. "Novel MR imaging and theranostics using Nano-DDS." Drug Delivery System 30, no. 1 (2015): 47–53. http://dx.doi.org/10.2745/dds.30.47.

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Gananathan, Poorani, Anirban Chakraborty, and Indrani Karunasagar. "Cancer Theranostics: Bridging Conventional and Nano-photodynamic Therapy." Journal of Health and Allied Sciences NU 10, no. 01 (April 2020): 03–08. http://dx.doi.org/10.1055/s-0040-1709959.

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AbstractCancer is of various kinds, so are the treatment modalities. Worldwide, cancer is the second leading cause of death, accounting for a whopping 9.6 million deaths in 2018. Globally, approximately one in six deaths is attributed to cancer. Photodynamic therapy (PDT) is a therapeutic strategy for the treatment of superficial lesions, warts, Barrett’s esophagus, premalignant lesions, malignant tumors, and ophthalmic diseases. The literature on PDT is approximately one-third of that in radiation therapy, yet the clinical implementation of PDT in cancer is relatively less. Despite substantial research, the clinical application of photodynamic strategy in cancer therapy is still in its infancy with only a limited number of case studies reported so far. The limitations of the photosensitizer and the shallow depth of penetration of light source are the key technical impediments. However, the use of nanomedicine in PDT can overcome these obstacles. Thus, it is necessary to gain knowledge on how nanomaterials can be merged with PDT and how it can be utilized in cancer theranostics. In this article, the focus is to understand how PDT works and how it can be utilized in improving the sensitivity of the existing diagnostic and therapeutic techniques. The article also addresses the current challenges for PDT and the future prospects of this technique, particularly in the area of diagnosis and treatment of cancer.

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Zhang, Zhihong, Yuan Qian, Honglin Jin, Minghai Luo, Chuan Huang, and Qingming Luo. "Peptide-lipid nano-delivery system for cancer theranostics." Nanomedicine: Nanotechnology, Biology and Medicine 14, no. 5 (July 2018): 1867. http://dx.doi.org/10.1016/j.nano.2017.11.337.

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Bennett, Kevin M., Jun-ichiro Jo, Horacio Cabral, Rumiana Bakalova, and Ichio Aoki. "MR imaging techniques for nano-pathophysiology and theranostics." Advanced Drug Delivery Reviews 74 (July 2014): 75–94. http://dx.doi.org/10.1016/j.addr.2014.04.007.

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Lin, Yuehe. "(Invited) Recent Progress in Functional Nanomaterials for Biosensing and Theranostics." ECS Meeting Abstracts MA2024-01, no. 49 (August 9, 2024): 2682. http://dx.doi.org/10.1149/ma2024-01492682mtgabs.

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In this talk, I will present an overview of our pioneering research in functional nanomaterials for biosensing and theranostics. Our work primarily focuses on novel materials such as protein cages, peptoids, single-atom nanozymes, and nanoflowers, and their applications in the field of biosensing and theranostics. Building on my extensive background in developing materials and systems for biosensors, including immunosensors and microfluidic devices, we have explored the development of various smartphone-based biosensors. These biosensors are primarily based on DNA assays and immunoassays for point-of-care diagnostics, significantly enhancing the detection of disease biomarkers. Our research utilizes nanomaterials loaded with optical or electroactive signal molecules as amplification tags, dramatically improving the sensitivity in detecting disease biomarkers and food pathogens. An exciting frontier in our research is the application of nano-peptoids in cell imaging, single-particle tracking, and cancer theranostics. The unique properties of nano-peptoids, including their biocompatibility and the ability for precise control over interactions, have opened new avenues in biomedicine and healthcare. These advancements hold promise for groundbreaking applications, particularly in enhancing the efficacy and precision of cancer diagnostics and treatment. Moreover, the integration of 3D printing technology has enabled us to fabricate compact and efficient devices, a testament to our commitment to innovation in biosensor technology. Throughout this talk, we will delve into the intricate details of these innovations, discussing their implications for the future of biosensing and theranostics.

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Bragazzi, Nicola Luigi. "Nanomedicine: Insights from a Bibliometrics-Based Analysis of Emerging Publishing and Research Trends." Medicina 55, no. 12 (December 15, 2019): 785. http://dx.doi.org/10.3390/medicina55120785.

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Background and Objectives: Nanomedicine, a term coined by the American engineer Eric Drexler (1955) and Robert Freitas Jr. (1952) in the nineties, can be defined as a complex, multi-disciplinary branch of medicine, in which nano-technologies, molecular biotechnologies, and other nano-sciences are applied at every step of disease management, from diagnosis (nano-diagnostics) to treatment (nano-therapeutics), prognosis, and monitoring of biological parameters and biomarkers. Nanomedicine is a relatively young discipline, which is increasingly and exponentially growing, characterized by emerging ethical issues and implications. Nanomedicine has branched out in hundreds of different sub-fields. Materials and Methods: A bibliometrics-based analysis was applied mining the entire content of PubMed/MEDLINE, using “nanomedicine” as a Medical Subject Heading (MeSH) search term. Results: A sample of 6696 articles were extracted from PubMed/MEDLINE and analyzed. Articles had been published in the period from 2003 to 2019, showing an increasing trend throughout the time. Six thematic clusters emerged (first cluster: molecular methods; second cluster: molecular biology and nano-characterization; third cluster: nano-diagnostics and nano-theranostics; fourth cluster: clinical applications, in the sub-fields of nano-oncology, nano-immunology and nano-vaccinology; fifth cluster: clinical applications, in the sub-fields of nano-oncology and nano-infectiology; and sixth cluster: nanodrugs). The countries with the highest percentages of articles in the field of nanomedicine were the North America (38.3%) and Europe (35.1%). Conclusions: The present study showed that there is an increasing trend in publishing and performing research in the super-specialty of nanomedicine. Most productive countries were the USA and European countries, with China as an emerging region. Hot topics in the last years were nano-diagnostics and nano-theranostics and clinical applications in the sub-fields of nano-oncology and nano-infectiology.

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Xia, Qingxiu, Hui Jiang, Xiaohui Liu, Lihong Yin, and Xuemei Wang. "Advances in Engineered Nano-Biosensors for Bacteria Diagnosis and Multidrug Resistance Inhibition." Biosensors 14, no. 2 (January 23, 2024): 59. http://dx.doi.org/10.3390/bios14020059.

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Bacterial infections continue to pose a significant global health challenge, with the emergence of multidrug-resistant (MDR) bacteria and biofilms further complicating treatment options. The rise of pan-resistant bacteria, coupled with the slow development of new antibiotics, highlights the urgent need for new therapeutic strategies. Nanotechnology-based biosensors offer fast, specific, sensitive, and selective methods for detecting and treating bacteria; hence, it is a promising approach for the diagnosis and treatment of MDR bacteria. Through mechanisms, such as destructive bacterial cell membranes, suppression of efflux pumps, and generation of reactive oxygen species, nanotechnology effectively combats bacterial resistance and biofilms. Nano-biosensors and related technology have demonstrated their importance in bacteria diagnosis and treatment, providing innovative ideas for MDR inhibition. This review focuses on multiple nanotechnology approaches in targeting MDR bacteria and eliminating antimicrobial biofilms, highlighting nano-biosensors via photodynamics-based biosensors, eletrochemistry biosensors, acoustic-dynamics sensors, and so on. Furthermore, the major challenges, opportunities of multi-physical-field biometrics-based biosensors, and relevant nanotechnology in MDR bacterial theranostics are also discussed. Overall, this review provides insights and scientific references to harness the comprehensive and diverse capabilities of nano-biosensors for precise bacteria theranostics and MDR inhibition.

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Gilani, Sadaf Jamal, Sarwar Beg, Chandra Kala, Mohammed Shivli Nomani, Debarshi Kar Mahapatra, Syed Sarim Imam, and Mohamad Taleuzzaman. "Chemically Nano-Engineered Theranostics for Phytoconstituents as Healthcare Application." Current Biochemical Engineering 6, no. 1 (March 12, 2020): 53–61. http://dx.doi.org/10.2174/2212711906666190723144111.

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Background: Nanomedicines are capable of disease diagnosis, drug delivery, and in monitoring the therapeutic result to provide appropriate tasks towards research goals. The best therapeutic pattern can be achieved by developing a theranostic nanomedicine, which is an emerging field. It has the advantage of loading phytoconstituents as drugs and is useful for both imaging and therapeutic function. Methods: Nowadays, the design of a novel drug delivery system of the herbal constituent is usually done through the nanotechnology approach. This technique increases the biological activity and counters the puzzles associated with plant medicines. Traditional medicine integration with nanocarriers as an NDDS is very essential in the management of chronic diseases such as hypertension, diabetes, and cancer. Results: The nanotechnology combination with plant science is a green revolution with a practical approach for decreasing the therapeutic side effects. The object of the study is to review herbal nanomedicine with an enhanced therapeutic profile and less toxicity. Conclusion: The development of herbal theranostic nanoformulation is very useful for the treatment of different diseases.

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Gundogan, Buket, Aaron Tan, Yasmin Farhatnia, Mohammad S. Alavijeh, Zhanfeng Cui, and Alexander M. Seifalian. "Bioabsorbable Stent Quo Vadis: A Case for Nano-Theranostics." Theranostics 4, no. 5 (2014): 514–33. http://dx.doi.org/10.7150/thno.8137.

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Liu, Zhuang. "Nano-theranostics for imaging-guided phototherapy: Fighting cancer metastasis." Nanomedicine: Nanotechnology, Biology and Medicine 12, no. 2 (February 2016): 462. http://dx.doi.org/10.1016/j.nano.2015.12.045.

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Huston, Ronald L. "Electromagnetic Enhancement of Cancer Cells as Biomarkers for Nano Theranostics." Nanotechnology: Nanomedicine & Nanobiotechnology 4, no. 2 (June 29, 2017): 1–5. http://dx.doi.org/10.24966/ntmb-2044/100015.

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Rehman, F. U., C. Zhao, H. Jiang, and X. Wang. "Biomedical applications of nano-titania in theranostics and photodynamic therapy." Biomaterials Science 4, no. 1 (2016): 40–54. http://dx.doi.org/10.1039/c5bm00332f.

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Titanium dioxide (TiO₂) is one of the most abundantly used nanomaterials for human life. It is used in sunscreen, photovoltaic devices, biomedical applications and as a food additive and environmental scavenger.

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Prasad, Rajendra, Sandhya Aiyer, Deepak S. Chauhan, Rohit Srivastava, and Kaliaperumal Selvaraj. "Bioresponsive carbon nano-gated multifunctional mesoporous silica for cancer theranostics." Nanoscale 8, no. 8 (2016): 4537–46. http://dx.doi.org/10.1039/c5nr06756a.

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A successful design of a novel dual functional green fluorescent CQD functionalized mesoporous silica based nano-theranostic agent for targeted bio-imaging and bio-responsive drug release has been reported. This study proves that the release of a preloaded anticancer drug is triggered by exposure to a tumor like environment which makes it an efficient theranostic system for cancer therapy.

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Neagu, Anca-Narcisa, Taniya Jayaweera, Krishan Weraduwage, and Costel C. Darie. "A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era." International Journal of Molecular Sciences 25, no. 9 (May 2, 2024): 4981. http://dx.doi.org/10.3390/ijms25094981.

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We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice.

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Kundu, Paromita, Deepika Singh, Abhalaxmi Singh, and Sanjeeb K. Sahoo. "Cancer Nanotheranostics: A Nanomedicinal Approach for Cancer Therapy and Diagnosis." Anti-Cancer Agents in Medicinal Chemistry 20, no. 11 (July 8, 2020): 1288–99. http://dx.doi.org/10.2174/1871520619666190820145930.

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The panorama of cancer treatment has taken a considerable leap over the last decade with the advancement in the upcoming novel therapies combined with modern diagnostics. Nanotheranostics is an emerging science that holds tremendous potential as a contrivance by integrating therapy and imaging in a single probe for cancer diagnosis and treatment thus offering the advantage like tumor-specific drug delivery and at the same time reduced side effects to normal tissues. The recent surge in nanomedicine research has also paved the way for multimodal theranostic nanoprobe towards personalized therapy through interaction with a specific biological system. This review presents an overview of the nano theranostics approach in cancer management and a series of different nanomaterials used in theranostics and the possible challenges with future directions.

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Fan, Nannan, Ping Li, Chuanchen Wu, Xin Wang, Yongqing Zhou, and Bo Tang. "ALP-Activated Chemiluminescence PDT Nano-Platform for Liver Cancer-Specific Theranostics." ACS Applied Bio Materials 4, no. 2 (January 20, 2021): 1740–48. http://dx.doi.org/10.1021/acsabm.0c01504.

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Feng, Liangzhu, Ziliang Dong, Danlei Tao, Yicheng Zhang, and Zhuang Liu. "The acidic tumor microenvironment: a target for smart cancer nano-theranostics." National Science Review 5, no. 2 (June 24, 2017): 269–86. http://dx.doi.org/10.1093/nsr/nwx062.

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Abstract The acidic tumor microenvironment (TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article, we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards.

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Kumar, Akash, Nabojit Das, and Raja Gopal Rayavarapu. "Smart Platinum Nanostructures: A Journey from Synthesis to Advanced Theranostic Applications." Journal of Nanotheranostics 4, no. 3 (August 10, 2023): 384–407. http://dx.doi.org/10.3390/jnt4030017.

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A significant paradigm shift has been observed in the past decade in the area of theranostics owing to the development of various isotropic and anisotropic metal nanostructures, simultaneous with improved imaging modalities. Platinum-based nanostructures are advancing in a plethora of clinical applications as theranostics tools owing to their unique behavior concerning their size, shape, and surface chemistry at the nanoscale regime. Platinum nanostructures are optically active and provide significant potential to the field of theranostics by simplifying diagnosis and therapeutics, thus providing key solutions through nano-enabled technologies. The review emphasizes the potential of platinum nanostructures that have immense potential in vitro and in vivo scenarios as nanocarriers. Still, their potential in terms of photothermal active agents has not been well explored or reported. Nanotheranostics has emerged as a platform where various noble metal nanoparticles are effectively efficient as photothermal agents in bringing precision to therapy and diagnostics. Platinum, as an antioxidant and a stable nanocarrier, will enable them to act as photosensitizers when conjugated to affinity molecules and plays a key role in efficient treatment and diagnosis. The review envisions bringing together the possibilities of the safe-by-design synthesis of platinum nanostructures and their potential role in both in vitro and in vivo applications. A roadmap describing the challenges, pitfalls, and possibilities of influencing platinum nanostructures to overcome the existing biological/targeting barriers is elaborated. This review provides a literature survey on platinum nanostructures in theranostics, providing novel strategies in bio-imaging, diagnostics, and nanomedicine.

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Lim, Melissa Siaw Han, Takashi Ohtsuki, Fumiaki Takenaka, Kazuko Kobayashi, Masaru Akehi, Hirotaka Uji, Hirotsugu Kobuchi, Takanori Sasaki, Eiichi Ozeki, and Eiji Matsuura. "A Novel 89Zr-labeled DDS Device Utilizing Human IgG Variant (scFv): “Lactosome” Nanoparticle-Based Theranostics for PET Imaging and Targeted Therapy." Life 11, no. 2 (February 18, 2021): 158. http://dx.doi.org/10.3390/life11020158.

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“Theranostics,” a new concept of medical advances featuring a fusion of therapeutic and diagnostic systems, provides promising prospects in personalized medicine, especially cancer. The theranostics system comprises a novel 89Zr-labeled drug delivery system (DDS), derived from the novel biodegradable polymeric micelle, “Lactosome” nanoparticles conjugated with specific shortened IgG variant, and aims to successfully deliver therapeutically effective molecules, such as the apoptosis-inducing small interfering RNA (siRNA) intracellularly while offering simultaneous tumor visualization via PET imaging. A 27 kDa-human single chain variable fragment (scFv) of IgG to establish clinically applicable PET imaging and theranostics in cancer medicine was fabricated to target mesothelin (MSLN), a 40 kDa-differentiation-related cell surface glycoprotein antigen, which is frequently and highly expressed by malignant tumors. This system coupled with the cell penetrating peptide (CPP)-modified and photosensitizer (e.g., 5, 10, 15, 20-tetrakis (4-aminophenyl) porphyrin (TPP))-loaded Lactosome particles for photochemical internalized (PCI) driven intracellular siRNA delivery and the combination of 5-aminolevulinic acid (ALA) photodynamic therapy (PDT) offers a promising nano-theranostic-based cancer therapy via its targeted apoptosis-inducing feature. This review focuses on the combined advances in nanotechnology and material sciences utilizing the “89Zr-labeled CPP and TPP-loaded Lactosome particles” and future directions based on important milestones and recent developments in this platform.

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Yaung Kwee, Yaung Kwee, and Alfinda Novi Kristanti and Mochamad Zakki Fahmi Alfinda Novi Kristanti and Mochamad Zakki Fahmi. "Particular Aspects on Applying Nanocarbon Quantum Dots for HIV Inhibition and Theranostics: a Review." Journal of the chemical society of pakistan 43, no. 3 (2021): 361. http://dx.doi.org/10.52568/000570/jcsp/43.03.2021.

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Viral infection is a globally leading health issue, causing significantly unfavourable mortality with an adversely decreasing socio-economic growth. To solve those infections of global pandemic HIV specifically, the current utilization of highly active antiretroviral therapy (HAART) in human deficiency virus (HIV) theranostics has remarkably improved the life’s duration of patients infected by human immunodeficiency virus (HIV); however, the unfortunate drawbacks in combination with prolonged HAART therapy need to be used continuously along patient’s lifetime. Additionally, RNA virus of COVID-19 is also associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. Meanwhile, many scientific researchers have explored the successive novelty of carbon quantum dots (CQDs) as alternative to HIV or other related viruses theranostics in the field of antiviral drugs research, but the attempt has been still challenging to introduce perfect antiviral CQDs with excellent biocompatibility, drug resistance, and safety at several areas in the virus’s life cycle. On the contrary, CQDs-based nano-therapy is currently promising because those carbon quantum dots had multiple favourable properties, including significant antiviral response effects, water-soluble activity, color-tunable fluorescence, high yield, low cytotoxic behaviour, and promising biocompatibility. In this review, some effectively recent progress of promising CQDs forviral inhibition and theranostics explored by many studies are systematically summarized.

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Yaung Kwee, Yaung Kwee, and Alfinda Novi Kristanti and Mochamad Zakki Fahmi Alfinda Novi Kristanti and Mochamad Zakki Fahmi. "Particular Aspects on Applying Nanocarbon Quantum Dots for HIV Inhibition and Theranostics: a Review." Journal of the chemical society of pakistan 43, no. 3 (2021): 361. http://dx.doi.org/10.52568/000570.

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Viral infection is a globally leading health issue, causing significantly unfavourable mortality with an adversely decreasing socio-economic growth. To solve those infections of global pandemic HIV specifically, the current utilization of highly active antiretroviral therapy (HAART) in human deficiency virus (HIV) theranostics has remarkably improved the life’s duration of patients infected by human immunodeficiency virus (HIV); however, the unfortunate drawbacks in combination with prolonged HAART therapy need to be used continuously along patient’s lifetime. Additionally, RNA virus of COVID-19 is also associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. Meanwhile, many scientific researchers have explored the successive novelty of carbon quantum dots (CQDs) as alternative to HIV or other related viruses theranostics in the field of antiviral drugs research, but the attempt has been still challenging to introduce perfect antiviral CQDs with excellent biocompatibility, drug resistance, and safety at several areas in the virus’s life cycle. On the contrary, CQDs-based nano-therapy is currently promising because those carbon quantum dots had multiple favourable properties, including significant antiviral response effects, water-soluble activity, color-tunable fluorescence, high yield, low cytotoxic behaviour, and promising biocompatibility. In this review, some effectively recent progress of promising CQDs forviral inhibition and theranostics explored by many studies are systematically summarized.

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Stępień, Ewa Ł., Carina Rząca, and Paweł Moskal. "Novel biomarker and drug delivery systems for theranostics – extracellular vesicles." Bio-Algorithms and Med-Systems 17, no. 4 (December 1, 2021): 301–9. http://dx.doi.org/10.1515/bams-2021-0183.

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Abstract Extracellular vesicles (EVs) are nano- and micro-sized double-layered membrane entities derived from most cell types and released into biological fluids. Biological properties (cell-uptake, biocompatibility), and chemical (composition, structure) or physical (size, density) characteristics make EVs a good candidate for drug delivery systems (DDS). Recent advances in the field of EVs (e.g., scaling-up production, purification) and developments of new imaging methods (total-body positron emission tomography [PET]) revealed benefits of radiolabeled EVs in diagnostic and interventional medicine as a potential DDs in theranostics.

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Thangam, Ramar, Ramasamy Paulmurugan, and Heemin Kang. "Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging." Nanomaterials 12, no. 1 (December 22, 2021): 18. http://dx.doi.org/10.3390/nano12010018.

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Functionalized nanomaterials of various categories are essential for developing cancer nano-theranostics for brain diseases; however, some limitations exist in their effectiveness and clinical translation, such as toxicity, limited tumor penetration, and inability to cross blood–brain and blood-tumor barriers. Metal nanomaterials with functional fluorescent tags possess unique properties in improving their functional properties, including surface plasmon resonance (SPR), superparamagnetism, and photo/bioluminescence, which facilitates imaging applications in addition to their deliveries. Moreover, these multifunctional nanomaterials could be synthesized through various chemical modifications on their physical surfaces via attaching targeting peptides, fluorophores, and quantum dots (QD), which could improve the application of these nanomaterials by facilitating theranostic modalities. In addition to their inherent CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PAI (Photo-acoustic imaging), and X-ray contrast imaging, various multifunctional nanoparticles with imaging probes serve as brain-targeted imaging candidates in several imaging modalities. The primary criteria of these functional nanomaterials for translational application to the brain must be zero toxicity. Moreover, the beneficial aspects of nano-theranostics of nanoparticles are their multifunctional systems proportioned towards personalized disease management via comprising diagnostic and therapeutic abilities in a single biodegradable nanomaterial. This review highlights the emerging aspects of engineered nanomaterials to reach and deliver therapeutics to the brain and how to improve this by adopting the imaging modalities for theranostic applications.

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Vittorio, Massimo De. "Wearable Piezoelectric Sensor Technologies for Health Monitoring." Proceedings 15, no. 1 (July 15, 2019): 27. http://dx.doi.org/10.3390/proceedings2019015027.

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The combination of micro- and nano-technologies with micro-mechanic, photonic, electronic and (bio)chemical approaches is producing completely new, compact and effective tools for diagnostics and therapeutics, which can be disposable, wearable, implantable or tattooable. These new technologies are opening the way to closed loop theranostics, i.e., device integrating advanced sensing and diagnostic capabilities and therapeutic response. In order to enable these new class of transducers for continuous and real time health monitoring, ultrathin and compliant non-intrusive smart technologies are required.

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Aoki, Ichio. "Nano-theranostics and Nitroxyl Radical-labeled Antitumor Agents for Magnetic Resonance Imaging." YAKUGAKU ZASSHI 136, no. 8 (August 1, 2016): 1087–91. http://dx.doi.org/10.1248/yakushi.15-00234-3.

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Jiang, Huiling, Yilin Du, Leilei Chen, Min Qian, Yafeng Yang, Taotao Huo, Xueying Yan, et al. "Multimodal theranostics augmented by transmembrane polymer-sealed nano-enzymatic porous MoS2 nanoflowers." International Journal of Pharmaceutics 586 (August 2020): 119606. http://dx.doi.org/10.1016/j.ijpharm.2020.119606.

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Papahadjopoulos-Sternberg, Brigitte. "Freeze-Fracture Electron Microscopy on Nano- and Microcarrier for Theranostics and Antibiotics." Biophysical Journal 102, no. 3 (January 2012): 188a. http://dx.doi.org/10.1016/j.bpj.2011.11.1026.

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Vij, Neeraj. "Nano-based theranostics for chronic obstructive lung diseases: challenges and therapeutic potential." Expert Opinion on Drug Delivery 8, no. 9 (June 28, 2011): 1105–9. http://dx.doi.org/10.1517/17425247.2011.597381.

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Choi, Hyeryeon, and Kwangsoon Kim. "Theranostics for Triple-Negative Breast Cancer." Diagnostics 13, no. 2 (January 11, 2023): 272. http://dx.doi.org/10.3390/diagnostics13020272.

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Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor prognosis. Current endocrine therapy or anti HER-2 therapy is not available for these patients. Chemotherapeutic treatment response varies among patients due to the disease heterogeneity. To overcome these challenges, theranostics for treating TNBC have been widely investigated. Anticancer material conjugated nanoparticles with target-binding ligand and tracer agents enable simultaneous drug delivery and visualization of the lesion with minimal off-target toxicity. In this review, we summarize recently FDA-approved targeted therapies for TNBC, such as poly-ADP-ribose polymerase (PARP) inhibitors, check point inhibitors, and antibody-drug conjugates. Particularly, novel theranostic approaches including lipid-based, polymer-based, and carbon-based nanocarriers are discussed, which can provide basic overview of nano-therapeutic modalities in TNBC diagnosis and treatment.

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Mohapatra, Shyam S., Robert D. Frisina, Subhra Mohapatra, Kevin B. Sneed, Eleni Markoutsa, Tao Wang, Rinku Dutta, et al. "Advances in Translational Nanotechnology: Challenges and Opportunities." Applied Sciences 10, no. 14 (July 16, 2020): 4881. http://dx.doi.org/10.3390/app10144881.

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The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area of research and development in the US and globally. NanoFlorida was founded to create a forum for scientific exchange, promote networking among nanoscientists, encourage collaborative research efforts across institutions, forge strong industry-academia partnerships in nanoscience, and showcase the contributions of students and trainees in nanotechnology fields. The 2019 NanoFlorida International Conference expanded this vision to emphasize national and international participation, with a focus on advances made in translating nanotechnology. This review highlights notable research in the areas of engineering especially in optics, photonics and plasmonics and electronics; biomedical devices, nano-biotechnology, nanotherapeutics including both experimental nanotherapies and nanovaccines; nano-diagnostics and -theranostics; nano-enabled drug discovery platforms; tissue engineering, bioprinting, and environmental nanotechnology, as well as challenges and directions for future research.

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Evangelopoulos, Michael, Alessandro Parodi, Jonathan Martinez, and Ennio Tasciotti. "Trends towards Biomimicry in Theranostics." Nanomaterials 8, no. 9 (August 21, 2018): 637. http://dx.doi.org/10.3390/nano8090637.

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Over the years, imaging and therapeutic modalities have seen considerable progress as a result of advances in nanotechnology. Theranostics, or the marrying of diagnostics and therapy, has increasingly been employing nano-based approaches to treat cancer. While first-generation nanoparticles offered considerable promise in the imaging and treatment of cancer, toxicity and non-specific distribution hindered their true potential. More recently, multistage nanovectors have been strategically designed to shield and carry a payload to its intended site. However, detection by the immune system and sequestration by filtration organs (i.e., liver and spleen) remains a major obstacle. In an effort to circumvent these biological barriers, recent trends have taken inspiration from biology. These bioinspired approaches often involve the use of biologically-derived cellular components in the design and fabrication of biomimetic nanoparticles. In this review, we provide insight into early nanoparticles and how they have steadily evolved to include bioinspired approaches to increase their theranostic potential.

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Asif, Samia, and sammia Shahid. "Emerging Trends in Nano-Theranostics: Platinum-based Drug Delivery Systems for Cancer Treatment." Global Drug Design & Development Review VIII, no. II (June 30, 2023): 15–28. http://dx.doi.org/10.31703/10.31703/gdddr.2023(viii-ii).03.

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Nanotechnology is the most common and frequently used technology that aims to improve the efficacy of medical procedures, sometimes known as Nanomedicine. With their impressive pharmacological efficacy as nanomedicines and delivery systems, nano materials have been recognized as attractive diagnostic and chemotherapeutic tools to treat diseases. To treat a wide range of solid malignant tumors, Drugs built on platinum complexes are now the foundation for many other therapies. They are often used to treat a varietym of solid tumors in the clinic, including head and neck, colorectal, lung and other malignancies. Cell-specific targeting with nano-carriers is possible using both active and passive techniques. This paper provides a thorough overview of platinum-based drug delivery system with the help of nanotechnology. Their mechanisms of action used in the treatment of cancer and potential for further development are all anticipated.

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Asif, Samia, and sammia Shahid. "Emerging Trends in Nano-Theranostics: Platinum-based Drug Delivery Systems for Cancer Treatment." Global Drug Design & Development Review VIII, no. II (June 30, 2023): 15–28. http://dx.doi.org/10.31703/gdddr.2023(viii-ii).03.

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Nanotechnology is the most common and frequently used technology that aims to improve the efficacy of medical procedures, sometimes known as Nanomedicine. With their impressive pharmacological efficacy as nanomedicines and delivery systems, nano materials have been recognized as attractive diagnostic and chemotherapeutic tools to treat diseases. To treat a wide range of solid malignant tumors, Drugs built on platinum complexes are now the foundation for many other therapies. They are often used to treat a varietym of solid tumors in the clinic, including head and neck, colorectal, lung and other malignancies. Cell-specific targeting with nano-carriers is possible using both active and passive techniques. This paper provides a thorough overview of platinum-based drug delivery system with the help of nanotechnology. Their mechanisms of action used in the treatment of cancer and potential for further development are all anticipated.

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Jahandar, Marzieh, Ali Zarrabi, Mohammad Ali Shokrgozar, and Hajar Mousavi. "Synthesis, characterization and application of polyglycerol coated Fe3O4nanoparticles as a nano-theranostics agent." Materials Research Express 2, no. 12 (December 14, 2015): 125002. http://dx.doi.org/10.1088/2053-1591/2/12/125002.

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Juanola-Feliu, Esteve, Pere Miribel-Català, Cristina Avilés, Jordi Colomer-Farrarons, Manel González-Piñero, and Josep Samitier. "Design of a Customized Multipurpose Nano-Enabled Implantable System for In-Vivo Theranostics." Sensors 14, no. 10 (October 16, 2014): 19275–306. http://dx.doi.org/10.3390/s141019275.

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Journal articles on the topic 'Nano-Theranostics'

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