Academic literature on the topic 'Myeloschisis'

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Journal articles on the topic "Myeloschisis"

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Oi, Shizuo, Hideyoshi Saya, and Satoshi Matsumoto. "A hypothesis for myeloschisis: overgrowth and reopening." Journal of Neurosurgery 68, no. 6 (June 1988): 947–54. http://dx.doi.org/10.3171/jns.1988.68.6.0947.

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✓ A hypothesis for embryopathogenesis of myeloschisis is described on the basis of experimental studies analyzing the stage specificity and immunohistochemical/histological characteristics of the exposed neural tissue (placode). Myeloschisis developed in six fetuses among 205 chick embryos treated in various stages with teratogens including ethylnitrosourea, and anticonvulsant and antipyretic agents. All but one case (with associated cephalothoracopagus) demonstrated myeloschisis in the thoracic region with a lamina defect of two and three levels. No fetus was exposed to a teratogen prior to or within Hamburger and Hamilton stage 12 (45 to 49 hours postincubation), when the neuropore closes. Immunohistochemical studies of chick myeloschisis clearly indicated that neuron-specific enolase-positive elements were extremely active only in the overgrown placode, corresponding to the histological findings with Kluver-Barrera's special stain. These findings were compared with observations in a case of myeloschisis in a human neonate. The results of this study imply the possibility of another mechanism for the embryopathogenesis of myeloschisis: namely, the overgrowth and reopening hypothesis.
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Schindelmann, Kim Hannah, Fabienne Paschereit, Alexandra Steege, Gisela Stoltenburg-Didinger, and Angela M. Kaindl. "Systematic Classification of Spina Bifida." Journal of Neuropathology & Experimental Neurology 80, no. 4 (February 12, 2021): 294–305. http://dx.doi.org/10.1093/jnen/nlab007.

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Abstract Spina bifida (SB) is an umbrella term for multiple conditions characterized by misclosure of vertebral arches. Neuropathologic findings in SB cases are often reported with imprecise and overlapping terminology. In view of the increasing identification of SB-associated genes and pathomechanisms, the precise description of SB subtypes is highly important. In particular, the term “myelomeningocele” is applied to various and divergent SB subtypes. We reevaluated 90 cases with SB (58 prenatal; 32 postnatal). The most frequent SB phenotype in our cohort was myeloschisis, which is characterized by an open neural plate with exposed ependyma (n = 28; 31.1%). An open neural plate was initially described in only in two-thirds of the myeloschisis cases. An additional 21 cases (23.3%) had myelomeningocele; 2 cases (2.2%) had a meningocele; and 21 cases (23.3%) had an unspecified SB aperta (SBA) subtype. Overall, the SB phenotype was corrected in about one-third of the cases. Our findings highlight that “myelomeningocele” and “SB aperta” cannot be used as synonymous terms and that myeloschisis is an underreported SB phenotype. Based on our findings and a review of literature we propose a classification of SB subtypes in SB occulta and the 3 SBA subtypes, meningocele, myelomeningocele, and myeloschisis.
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Jeelani, Yasser, and J. Gordon McComb. "Congenital hydrocephalus associated with myeloschisis." Child's Nervous System 27, no. 10 (September 17, 2011): 1585–88. http://dx.doi.org/10.1007/s00381-011-1560-4.

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Oi, Shizuo, Takashi Kokunai, Yasuhiro Okuda, Matsuto Sasaki, and Satoshi Matsumoto. "Identical embryopathogenesis for exencephaly and myeloschisis: an experimental study." Journal of Neurosurgery 72, no. 3 (March 1990): 450–57. http://dx.doi.org/10.3171/jns.1990.72.3.0450.

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✓ Extensive histological and immunohistochemical studies were performed to elucidate the histopathogenesis of exencephaly induced in chick embryo as an experimental model. The findings were compared with those identified in a chick myeloschisis experimental model and in human autopsy cases. The experimental model of exencephaly in chick embryos was developed by induction with various teratogens including ethylnitrosourea, salicylate, and phenytoin. None of the cases of exencephaly was exposed to a teratogen prior to or within Hamburger and Hamilton stage 12 (45 to 49 hours postincubation), when the anterior neuropore closes. The process of overgrowth in development of exencephaly was identical to that of myeloschisis, and the results suggested neuronal overmaturation in the histological and immunohistochemical studies. Although the late-stage degenerative change with neovascularization over the exposed neural tissue (placode) was more severe in human exencephaly, the present experimental study may suggest a possible common embryopathogenesis of dysraphism. Exencephaly should be regarded as the most severe form of cranium bifidum, as myeloschisis is in spina bifida.
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Hong, Seung Kuan, Je G. Chi, and Bo Sung Sim. "Experimental exencephaly and myeloschisis in rats." Journal of Korean Medical Science 4, no. 1 (1989): 35. http://dx.doi.org/10.3346/jkms.1989.4.1.35.

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Morioka, Takato, Satoshi O. Suzuki, Nobuya Murakami, Takafumi Shimogawa, Nobutaka Mukae, Satoshi Inoha, Takakazu Sasaguri, and Koji Iihara. "Neurosurgical pathology of limited dorsal myeloschisis." Child's Nervous System 34, no. 2 (October 23, 2017): 293–303. http://dx.doi.org/10.1007/s00381-017-3625-5.

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MORIOKA, Takato, Kimiaki HASHIGUCHI, Nobutaka MUKAE, Tetsuro SAYAMA, and Tomio SASAKI. "Neurosurgical Management of Patients With Lumbosacral Myeloschisis." Neurologia medico-chirurgica 50, no. 9 (2010): 870–76. http://dx.doi.org/10.2176/nmc.50.870.

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Storck, Kristina, Joy Duong, Joseph Bruner, George Davis, Laura Stone, and George Reed. "588 Intrauterine repair of myelomeningocele vs myeloschisis." American Journal of Obstetrics and Gynecology 185, no. 6 (December 2001): S240. http://dx.doi.org/10.1016/s0002-9378(01)80620-7.

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Pang, Dachling, John Zovickian, Angelica Oviedo, and Greg S. Moes. "Limited Dorsal Myeloschisis: A Distinctive Clinicopathological Entity." Neurosurgery 67, no. 6 (December 1, 2010): 1555–80. http://dx.doi.org/10.1227/neu.0b013e3181f93e5a.

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Abstract BACKGROUND: Limited dorsal myeloschisis (LDM) is a distinctive form of spinal dysraphism characterized by 2 constant features: a focal “closed” midline defect and a fibroneural stalk that links the skin lesion to the underlying cord. The embryogenesis is hypothesized to be incomplete disjunction between cutaneous and neural ectoderms, thus preventing complete midline skin closure and allowing persistence of a physical link (fibroneural stalk) between the disjunction site and the dorsal neural tube. OBJECTIVE: To illustrate these features in 51 LDM patients. METHODS: All patients were studied with magnetic resonance imaging or computed tomography myelography, operated on, and followed for a mean of 7.4 years. RESULTS: There were 10 cervical, 13 thoracic, 6 thoracolumbar and 22 lumbar lesions. Two main types of skin lesion were saccular (21 patients), consisting of a skin-base cerebrospinal fluid sac topped with a squamous epithelial dome, and nonsaccular (30 patients), with a flat or sunken squamous epithelial crater or pit. The internal structure of a saccular LDM could be a basal neural nodule, a stalk that inserts on the dome, or a segmental myelocystocele. In nonsaccular LDMs, the fibroneural stalk has variable thickness and complexity. In all LDMs, the fibroneural stalk was tethering the cord. Twenty-nine patients had neurological deficits. There was a positive correlation between neurological grade and age, suggesting progression with chronicity. Treatment consisted of detaching the stalk from the cord. Most patients improved or remained stable. CONCLUSION: LDM is a distinctive clinicopathological entity and a tethering lesion with characteristic external and internal features. We propose a new classification incorporating both saccular and flat lesions.
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Eibach, Sebastian, Greg Moes, John Zovickian, and Dachling Pang. "Limited dorsal myeloschisis associated with dermoid elements." Child's Nervous System 33, no. 1 (August 19, 2016): 55–67. http://dx.doi.org/10.1007/s00381-016-3207-y.

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Dissertations / Theses on the topic "Myeloschisis"

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Ahmad, Saliha. "Preoperative, intraoperative, and postoperative planning for prenatal repair of myelomeningocele and myeloschisis." Thesis, 2021. https://hdl.handle.net/2144/42704.

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Following the publishing of the Management of Myelomeningocele Study, the advantages of in utero repair for fetal myelomeningoceles became points of interest for fetal surgeons. There are many variables that must align in order to have success in this type of repair. When a patient is eligible for this prenatal procedure it is preferable to perform it rather than do the repair postnatally as neurological outcomes for the infant tend to be much better following earlier intervention. It is very important to have a clear preoperative plan before beginning any fetal surgery. In doing so, one limits unforeseen events that may arise. With this in mind, we chose to analyze factors that affect the rates of patch placement (in lieu of a primary skin closure) during the prenatal repair and rates of shunt placement after the infant is born. A retrospective study was conducted on patients who underwent in utero repair for a myelomeningocele or myeloschisis defect at the Colorado Fetal Care Center. Multivariate analyses were performed to identify which preoperative, intraoperative, and postoperative factors were statistically significant (p ≤ 0.05) in predicting patch and shunt placement. Neuroimaging was found to be a key tool in predicting patch and shunt placement. Additionally, gestational age during prenatal intervention was found to be predictive of patch placement while the preoperative degree of cerebellar descent relative to the foramen magnum as well as 2-week hindbrain herniation classification were found to be predictive of shunt placement. These crucial findings will give physicians a framework to use when creating their preoperative plans and in doing so will allow for higher chances of success with this complex procedure.
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Book chapters on the topic "Myeloschisis"

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Takahashi, K., H. Tanaka, S. Nakahara, H. Nakazaki, T. Terao, and T. Abe. "The Pathogenesis of Myeloschisis: Experimental Studies." In Spina Bifida, 250–55. Tokyo: Springer Japan, 1999. http://dx.doi.org/10.1007/978-4-431-68373-5_53.

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Wong, Sui T., Amanda Kan, and Dachling Pang. "Limited Dorsal Spinal Nondisjunctional Disorders: Limited Dorsal Myeloschisis, Congenital Spinal Dermal Sinus Tract, and Mixed Lesions." In Textbook of Pediatric Neurosurgery, 2365–422. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-319-72168-2_110.

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Wong, Sui-To, Amanda Kan, and Dachling Pang. "Limited Dorsal Spinal Nondisjunctional Disorders: Limited Dorsal Myeloschisis, Congenital Spinal Dermal Sinus Tract, and Mixed Lesions." In Textbook of Pediatric Neurosurgery, 1–64. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-31512-6_110-1.

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Butterfield, Sarah, Beatriz Garcia-Gonzalez, Colin J. Driver, and Clare Rusbridge. "Limited dorsal myeloschisis in three cats: a distinctive form of neural tube defect." In BSAVA Congress Proceedings 2020, 520. British Small Animal Veterinary Association, 2020. http://dx.doi.org/10.22233/9781910443774.84.1.

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