Academic literature on the topic 'Mycobacterium smegmati'
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Journal articles on the topic "Mycobacterium smegmati"
Deng, Guoying, Fei Zhang, Shufeng Yang, Jian Kang, Shanshan Sha, and Yufang Ma. "Mycobacterium tuberculosis Rv0431 expressed in Mycobacterium smegmati s, a potentially mannosylated protein, mediated the immune evasion of RAW 264.7 macrophages." Microbial Pathogenesis 100 (November 2016): 285–92. http://dx.doi.org/10.1016/j.micpath.2016.10.013.
Full textPandey, N., K. Singh, F. Ahmad, and R. Sharma. "Characterization of biofilm formation by Mycobacterium smegmatis during different environmental stress conditions: An in-vitro study." Journal of Environmental Biology 43, no. 6 (November 15, 2022): 771–78. http://dx.doi.org/10.22438/jeb/43/6/mrn-4081.
Full textBurguière, Adeline, Paul G. Hitchen, Lynn G. Dover, Anne Dell, and Gurdyal S. Besra. "Altered expression profile of mycobacterial surface glycopeptidolipids following treatment with the antifungal azole inhibitors econazole and clotrimazole." Microbiology 151, no. 6 (June 1, 2005): 2087–95. http://dx.doi.org/10.1099/mic.0.27938-0.
Full textCai, Xiaoying, Lei Liu, Chunhong Qiu, Chongzheng Wen, Yao He, Yanxiang Cui, Siyu Li, et al. "Identification and architecture of a putative secretion tube across mycobacterial outer envelope." Science Advances 7, no. 34 (August 2021): eabg5656. http://dx.doi.org/10.1126/sciadv.abg5656.
Full textPoupin, P., J. J. Godon, E. Zumstein, and N. Truffaut. "Degradation of morpholine, piperidine, and pyrrolidine by mycobacteria: evidences for the involvement of a cytochrome P450." Canadian Journal of Microbiology 45, no. 3 (March 1, 1999): 209–16. http://dx.doi.org/10.1139/w99-002.
Full textHarth, Günter, Saša Masleša-Galić, and Marcus A. Horwitz. "A two-plasmid system for stable, selective-pressure-independent expression of multiple extracellular proteins in mycobacteria." Microbiology 150, no. 7 (July 1, 2004): 2143–51. http://dx.doi.org/10.1099/mic.0.27113-0.
Full textConverse, Scott E., and Jeffery S. Cox. "A Protein Secretion Pathway Critical for Mycobacterium tuberculosis Virulence Is Conserved and Functional in Mycobacterium smegmatis." Journal of Bacteriology 187, no. 4 (February 15, 2005): 1238–45. http://dx.doi.org/10.1128/jb.187.4.1238-1245.2005.
Full textKorycka-Machala, Malgorzata, Ewelina Rychta, Anna Brzostek, Heather R. Sayer, Anna Rumijowska-Galewicz, Richard P. Bowater, and Jarosław Dziadek. "Evaluation of NAD+-Dependent DNA Ligase of Mycobacteria as a Potential Target for Antibiotics." Antimicrobial Agents and Chemotherapy 51, no. 8 (June 4, 2007): 2888–97. http://dx.doi.org/10.1128/aac.00254-07.
Full textCayer, Marie-Pierre, Marc Veillette, Pascal Pageau, Richard Hamelin, Marie-Josée Bergeron, Anne Mériaux, Yvon Cormier, and Caroline Duchaine. "Identification of mycobacteria in peat moss processing plants: application of molecular biology approaches." Canadian Journal of Microbiology 53, no. 1 (January 1, 2007): 92–99. http://dx.doi.org/10.1139/w06-105.
Full textEl-Etr, Sahar H., Ling Yan, and Jeffrey D. Cirillo. "Fish Monocytes as a Model for Mycobacterial Host-Pathogen Interactions." Infection and Immunity 69, no. 12 (December 1, 2001): 7310–17. http://dx.doi.org/10.1128/iai.69.12.7310-7317.2001.
Full textDissertations / Theses on the topic "Mycobacterium smegmati"
Vorwieger, Stefan [Verfasser], and Dirk [Akademischer Betreuer] Wagner. "Efflux-Inhibition bei Mycobacterium smegmatis und Mycobacterium avium." Freiburg : Universität, 2012. http://d-nb.info/1123467102/34.
Full textMpongoshe, Vuyiseka. "Gene expression changes in macrophages infected with pathogenic M. tuberculosis and non-pathogenic M. smegmatis and M. bovis BCG." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86729.
Full textENGLISH ABSTRACT: The current anti-TB drugs have had success in decreasing the number of deaths caused by TB, however, this success is limited by the emergence of drug resistant TB strains. Therefore, a novel TB therapy that limits the development of resistance has become necessary in an attempt to effectively control TB. The anti-TB drugs directly target mycobacterial enzymes, and potentiate the development of this resistance, and have therefore provided the rationale for this study. The aim was therefore to identify host macrophage genes that affect M. tb intracellular survival. The proposed alternative anti-TB therapy potentially involves the application of RNA interference (RNAi) and RNA activation (RNAa) biological processes that will target host genes, thereby inducing an indirect bactericidal effect. We hypothesized that macrophage genes that are differentially expressed by pathogenic and non-pathogenic mycobacterial species may be important in the regulation of M. tb intracellular survival. The lipid-rich mycobacterial cell wall is implicated in the excessive clumping of the mycobacterial cells in liquid culture. In order to minimize this, Tween 80 detergent was supplemented (mycobacteriaT). However, due to substantial evidence emphasising the detrimental effects of Tween 80 on the mycobacterial cell wall, mycobacteria were also cultured without Tween 80 (mycobacteriaNT), in order to investigate if the perturbed mycobacterial cell wall induced by Tween 80 affects the transcriptional response of macrophages. We endeavoured to develop a new method to culture mycobacteria without Tween 80 that will still generate single cells. We further hypothesized that the macrophage gene expression profile induced by mycobateriaNT differs from the response induced by mycobacteriaT. Differentiated THP-1 (dTHP-1) cells were infected with pathogenic and non-pathogenic mycobacteria (for 3 h, 24 h and 48 h with M. tb and M. bovis BCG, and 3 h and 8 h with M. smegmatis) cultured in the presence or absence of Tween 80. The expression of 12 macrophage genes, selected based on their involvement in the phagocytic pathway and autophagy, as well as their general involvement in the immune response, was determined by qRT-PCR and further analysed on the REST programme. The expression of each target gene was normalised relative to the expression of the reference gene (Beta actin). We observed that out of the 12 genes, TLR7 and VAMP7 were consistently downregulated in dTHP-1 cells infected with M. tbNT and upregulated in dTHP-1 cells infected with M. smegmatisNT. Their response to M. bovis BCG was inconsistent and not significantly different, and therefore could not be interpreted. Furthermore, CCL1 was upregulated by all the mycobacterial species. However, its expression was more pronounced in response to mycobacteriaNT, when compared to mycobacteriaT. Differential gene expression of TLR7 and VAMP7 in response to pathogenic and non-pathogenic mycobacteriaNT suggests that these 2 genes may be potential targets for RNAa-based anti-TB therapy, even though we could not conclude whether their response was specific to macrophages. In addition, the observed difference in the expression of CCL1 induced by mycobacteriaNT, compared to mycobacteriaT suggests that the perturbation caused by Tween 80 on the mycobacterial cell wall most likely affected the response of macrophages to infection with mycobacteria. Furthermore, this study has demonstrated a feasible method by filtration to generate single cells from mycobacteriaNT, which should be considered for future mycobacterial infection studies.
AFRIKAANSE OPSOMMING: Die huidige anti-tuberkulose middels se sukses lê daarin dat dit die aantal sterftes verminder maar hierdie sukses word weer beperk met die ontstaan van middel-weerstandige M.tb stamme. Daarom is nuwe middels nodig wat die ontwikkeling van middel-weerstandigheid beperk in ʼn poging om effektiewe TB behandeling te bewerkstellig. Anti-tuberkulose middels teiken hoofsaaklik mycobakteriële ensiemsisteme en ontlok sodoende weerstandigheid in M.tb stamme en dit vorm die rasionale vir hierdie studie. Die doel was om gasheer makrofaag gene te identifiseer wat M.tb oorlewing intrasellulêr bewerkstellig. Die voorgestelde alternatiewe anti-TB behandeling sal dan behels die toepassing van RNA intervensie (RNAi) en RNA aktivering (RNAa) tegnologie wat gasheer selgene teiken (inaktiveer) en sodoende ʼn bakterisidiese respons induseer. Die kanse is skraal dat mycobakterieë weerstandigheid sal kan ontwikkel onder hierdie omstandighede. Ons hipotetiseer dus dat makrofaag gene wat differensieel uitgedruk word deur patogeniese en nie-patologiese mycobakteriële spesies belangrik mag wees vir die oorlewing van M.tb intrasellulêr. Die lipiedryke selwand van mycobakterieë word geïmpliseer in die oormatige sameklomping van die bakterieë in vloeistofkulture. Om hierdie effek te minimaliseer word Tween 80 normaalweg tot die medium gevoeg (mycobakterieëT). Maar weens genoegsame bewyse dat Tween-80 die selwand van bakterieë nadelig beïnvloed, is mycobakterieë ook in die afwesigheid van Tween 80 gekultureer (mycobakterieëNT) om te bepaal of die nadelige effek van Tween 80 op die selwand die transkripsionele respons in makrofage beïnvloed post-infeksie. Dit was daarom ook ons doelstelling om ʼn nuwe tegniek te ontwikkel om mycobakterieë te kultureer in die afwesigheid van Tween 80 wat ook enkelselle sal genereer vir beter gekontroleerde makrofaag infeksie. Ons hipotetiseer ook verder dat makrofaag geenuitdrukking-profiele verskil afhangende of infeksie gedoen is met mycobakterieë wat in die afwesigheid of teenwoordigheid van Tween 80 gekultureer is. Gedifferensieerde THP-1 (dTHP-1) was geïnfekteer met patogeniese en nie-patogeniese mycobakterieë (vir 3 h, 24 h en 48 h met M.tb en M.bovis BCG, en 3 h en 8 h met M.smegmatis) gekultureer in die teenwoordigheid en afwesigheid van Tween 80. Die uitdrukking van 12 makrofaag gene, geselekteer op grond van hul betrokkenheid in die fagositose meganisme en in outofagie asook hul betrokkenheid in die immuunrespons, is gekwantifiseer met qRT-PCR en daaropvolgens geanaliseer met die REST-program. Die uitdrukking van elke geen is genormaliseer relatief tot die uitdrukking van die verwysingsgeen (Beta actin). Daar is bevind dat van die 12 gene, TLR7 en VAMP7 deurlopend afgereguleer was in dTHP-1 selle geïnfekteer met M.tbNT en opgereguleer was in dTHP selle geïnfekteer met M.smegmatisNT. Selrespons met M.bovis BCG was onbeduidend en derhalwe kon geen gevolgtrekking hier gemaak word nie. Ook, CCL1 was opgereguleer met infeksie deur enige van die mycobakteriële spesies, maar CCL1 se uitdrukking was groter in respons tot mycobakterieëNT wanneer vergelyk word met respons tot mycobakterieëT. Differensiële geenuitdrukking van TLR7 en VAMP7 in respons tot patogeniese en nie-patogeniese mycobakterieëNT impliseer dat hierdie twee gene potensiële teikens kan wees vir RNAa-gebaseerde anti-TB behandeling, alhoewel ons nie kon beslis of hierdie respons spesifiek vir makrofage was nie. Ook, die verskille waargeneem in die uitdrukking van CCL1 geïnduseer deur mycobakterieëNT, vergeleke met mycobakterieëT, impliseer dat die steuring in die selwand veroorsaak deur Tween 80, heelwaarskynlik die respons van die makrofaag beïnvloed het. Hierdie studie beskryf ook ʼn filtrasiemetode om enkele mycobakteriële selle te genereer wat oorweeg moet word by toekomstige mycobakteriële infeksiestudies.
CHIARELLI, PERDOMO IGOR. "PRODUCTION OF NATURAL AROMA COMPOUNDS BY BIOCATALYSIS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/694810.
Full textEsters play a significant role in the food industry, they are among the most important and versatile components of natural flavours and fragrances in food, drinks and cosmetics Their preparation starting from natural substrates and using bioprocesses (e.g., fermentation or enzymatic reactions) is appealing, since the final product can be labelled and commercialized in EU and USA as natural. Therefore, new biotechnological approaches for obtaining flavours are highly demanded as long as they are efficient and sustainable. Many flavour/fragrance esters can be enzymatically obtained using lipases that catalyse esterification, transesterification or interesterification reactions. In this PhD thesis we studied two systems for production of flavours esters: 1) A straightforward biocatalytic method for the enzymatic preparation of different flavour esters starting from primary alcohols (e.g., isoamyl, n-hexyl, geranyl, cinnamyl, 2-phenethyl, and benzyl alcohols) and naturally available ethyl esters (e.g., formate, acetate, propionate, and butyrate) was developed. The biotransformations are catalysed by an acyltransferase from Mycobacterium smegmatis (MsAcT) and preceded with excellent yields (80-97%) and short reaction times (30-120 minutes), even when high substrate concentrations (up to 0.5 M) were used. This enzymatic strategy represents an efficient alternative to the application of lipases in organic solvents and a significant improvement compared to already known methods in terms of reduced use of organic solvents, paving the way to a sustainable and efficient preparation of natural flavouring agents. 2) Mycelium-bound lipase of dry mycelium of Aspergillus oryzae catalysed direct esterification of alcohols and acetic acid in organic solvent, showing high stability towards substrates and products. Water produced during the esterification did not significantly affect the equilibrium of the reaction, allowing for high conversions. These features were exploited for preparing flavour-active acetate esters (e.g., isoamyl and cinnamyl acetate) in batch and continuous systems. A continuous stirred tank membrane reactor (CST-MR) was developed securing good reactor productivity and high biocatalyst stability. Both production systems are promising, represent two different alternatives and can be further optimized and scaled up for the interests of the industry.
Mahenthiralingam, Eshwar. "The amidase promotor of Mycobacterium smegmatis." Thesis, Open University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278899.
Full textBruell, Christian M. "Mechanism of protein synthesis in Mycobacterium smegmatis /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17733.
Full textTrower, Carolyn Joy 1975. "A preliminary investigation of a sialidase activity associated with M. smegmatis." Monash University, Dept. of Medicinal Chemistry, 2003. http://arrow.monash.edu.au/hdl/1959.1/7646.
Full textBerger, Sven. "Expression der Poren bildenden Hämolysine Listeriolysin und TlyA in Mycobacterium smegmatis." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964920824.
Full textFaller, Michael. "Kristallstruktur eines mycobacteriellen Porins." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972775730.
Full textSmeulders, Maria Jeanne. "The stationary phase survival response of Mycobacterium smegmatis." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287866.
Full textSikder, Mahmudul Hasan. "Characterisation of the Mycobacterium smegmatis transcriptional regulator MSMEG_5424." Thesis, Royal Veterinary College (University of London), 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618297.
Full textBook chapters on the topic "Mycobacterium smegmati"
Majumdar, Gaurav, Rendani Mbau, Vinayak Singh, Digby F. Warner, Marte Singsås Dragset, and Raju Mukherjee. "Genome-Wide Transposon Mutagenesis in Mycobacterium tuberculosis and Mycobacterium smegmatis." In Methods in Molecular Biology, 321–35. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6472-7_21.
Full textBhatt, Apoorva, and William R. Jacobs. "Gene Essentiality Testing in Mycobacterium smegmatis Using Specialized Transduction." In Methods in Molecular Biology, 325–36. Totowa, NJ: Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-207-6_22.
Full textClark, Ryan R., Todd A. Gray, and Keith M. Derbyshire. "Quantifying and Characterizing Distributive Conjugal Transfer in Mycobacterium smegmatis." In Horizontal Gene Transfer, 123–34. New York, NY: Springer US, 2019. http://dx.doi.org/10.1007/978-1-4939-9877-7_9.
Full textBloch, Konrad. "Control Mechanisms for Fatty Acid Synthesis in Mycobacterium Smegmatis." In Advances in Enzymology - and Related Areas of Molecular Biology, 1–84. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470122907.ch1.
Full textGarcía-Fernández, Julia, Igor Martínez, Lorena Fernández-Cabezón, Carmen Felpeto-Santero, José-Luis García, and Beatriz Galán. "Bioconversion of Phytosterols into Androstadienedione by Mycobacterium smegmatis CECT 8331." In Microbial Steroids, 211–25. New York, NY: Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7183-1_15.
Full textChelliah, Ramachandran, and Deog-Hwan Oh. "Screening of Actinobacterial Cultures for Antimycobacterial Activity Using Mycobacterium smegmatis." In Methods in Actinobacteriology, 391–93. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-1728-1_47.
Full textConference papers on the topic "Mycobacterium smegmati"
SYAHPUTRA, GITA. "Anti-mycobacterial activity of methanol plants extract to against Mycobacterium bovis and Mycobacterium smegmatis." In Seminar Nasional Masyarakat Biodiversitas Indonesia. Masyarakat Biodiversitas Indonesia, 2016. http://dx.doi.org/10.13057/psnmbi/m020211.
Full textBruce-Micah, R., U. Gamm, D. Hüttenberger, J. Cullum, and H. J. Foth. "Photodynamic inactivation of the models Mycobacterium phlei and Mycobacterium smegmatis in vitro." In European Conference on Biomedical Optics. Washington, D.C.: OSA, 2009. http://dx.doi.org/10.1364/ecbo.2009.7373_1l.
Full textBruce-Micah, R., U. Gamm, D. Hüttenberger, J. Cullum, and H. J. Foth. "Photodynamic inactivation of the models Mycobacterium phlei and Mycobacterium smegmatis in vitro." In European Conferences on Biomedical Optics, edited by Ronald Sroka and Lothar D. Lilge. SPIE, 2009. http://dx.doi.org/10.1117/12.831872.
Full textMorita, Yasu S., Svetozar Kovacevic, Helen Billman-Jacobe, and Malcolm J. McConville. "RECONSTITUTION OF PHOSPHATIDYLINOSITOL MANNOSIDE BIOSYNTHESIS IN MYCOBACTERIUM SMEGMATIS." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.453.
Full textPatterson, John H., Dharshini Jeevarajah, Helen Billman-Jacobe, and Malcolm J. McConville. "DELETION OF PHOSPHOMANNOSE ISOMERASE IN MYCOBACTERIUM SMEGMATIS REVEALS ESSENTIAL MANNOSE CONTAINING GLYCOCONJUGATES." In XXIst International Carbohydrate Symposium 2002. TheScientificWorld Ltd, 2002. http://dx.doi.org/10.1100/tsw.2002.399.
Full textКарпов, М. В., Н. И. Стрижов, А. А. Шутов, and М. В. Донова. "Биоконверсия холестерина в прогестерон рекомбинантными штаммами Mycobacterium smegmatis mc2155 с делециями в генах окисления стероидного ядра." In VI Пущинская школа-конференция «Биохимия, физиология и биосферная роль микроорганизмов». ИД «Вода: химия и экология», 2019. http://dx.doi.org/10.18334/ibpm2019.200-201.
Full textКарпов, М. В., Н. И. Стрижов, А. А. Шутов, and М. В. Донова. "Биоконверсия холестерина в прогестерон рекомбинантными штаммами Mycobacterium smegmatis mc2155 с делециями в генах окисления стероидного ядра." In VI Пущинская школа-конференция «Биохимия, физиология и биосферная роль микроорганизмов». ИД «Вода: химия и экология», 2019. http://dx.doi.org/10.18334/ibpm2019_200-201.
Full textPereira, Victor, Marcos Schwarz, and Leila Lima. "Use of a theophylline responsive riboswitch for translational control applied to the expression of secreted heterologous proteins in Mycobacterium smegmatis." In International Symposium on Immunobiological. Instituto de Tecnologia em Imunobiológicos, 2021. http://dx.doi.org/10.35259/isi.2021_46598.
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