Relevant bibliographies by topics / Mycobacterium paratuberculosis

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Academic literature on the topic 'Mycobacterium paratuberculosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 January 2023

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Journal articles on the topic "Mycobacterium paratuberculosis"

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Cocito, C., P. Gilot, M. Coene, M. de Kesel, P. Poupart, and P. Vannuffel. "Paratuberculosis." Clinical Microbiology Reviews 7, no. 3 (July 1994): 328–45. http://dx.doi.org/10.1128/cmr.7.3.328.

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Paratuberculosis (Johne's disease) is a chronic, wasting, widespread mycobacteriosis of ruminants. It involves extensive mycobacterial shedding, which accounts for the high contagiousness, and ends with a fatal enteritis. Decreases in weight, milk production, and fertility produce severe economic loss. The DNA of the etiological agent (Mycobacterium paratuberculosis) has a base composition (66 to 67% G+C) within the range of that of mycobacteria (62 to 70% G+C), a size (4.4 x 10(6) to 4.7 x 10(6) bp) larger than that of most pathogenic mycobacteria (2.0 x 10(6) to 4.2 x 10(6) bp), and a high relatedness (> 90%) to Mycobacterium avium DNA. However, the DNAs of the two organisms can be distinguished by restriction fragment length polymorphism analysis. M. paratuberculosis genes coding for a transposase, a cell wall-associated protein (P34), and two heat shock proteins have been cloned and sequenced. Nucleic acid probes (two of which are species specific) are used, after PCR amplification, for M. paratuberculosis identification in stools and milk. As in leprosy, with disease progression, cellular immune reactions decrease and humoral immune reactions increase. Cutaneous testing with sensitins, lymphocyte proliferation assays, and cytokine tests are used to monitor cellular immune reactions in paratuberculosis, but these tests lack specificity. Complement fixation, immunodiffusion, and enzymometric tests based on antibodies to M. paratuberculosis extracts, to mycobacterial antigen complex A36, to glycolipids, and to proteins help identify affected cattle but are not species specific. The carboxyl-terminal portion of the 34-kDa cell wall-associated A36 protein (P34) carries species-specific B-cell epitopes and is the basis for an enzyme-linked immunosorbent assay. Diagnostic tests for paratuberculosis are also used in Crohn's disease, a chronic human ileitis mimicking Johne's disease, in which isolates identified as M. paratuberculosis have been found.
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Waters, W. R., B. J. Nonnecke, M. V. Palmer, S. Robbe-Austermann, J. P. Bannantine, J. R. Stabel, D. L. Whipple, et al. "Use of Recombinant ESAT-6:CFP-10 Fusion Protein for Differentiation of Infections of Cattle by Mycobacterium bovis and by M. avium subsp. avium and M. avium subsp. paratuberculosis." Clinical Diagnostic Laboratory Immunology 11, no. 4 (July 2004): 729–35. http://dx.doi.org/10.1128/cdli.11.4.729-735.2004.

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ABSTRACT Immunological diagnosis of Mycobacterium bovis infection of cattle is often confounded by cross-reactive responses resulting from exposure to other mycobacterial species, especially Mycobacterium avium. Early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10) are dominant gamma interferon (IFN-γ)-inducing antigens of tuberculous mycobacteria, and they are absent from many environmental nontuberculous mycobacteria. Because M. avium exposure is the primary confounding factor in the diagnosis of M. bovis-infected animals, in vitro responses to a recombinant ESAT-6:CFP-10 (rESAT-6:CFP-10) fusion protein by blood leukocytes from cattle naturally exposed to M. avium or experimentally challenged with Mycobacterium avium subsp. avium or Mycobacterium avium subsp. paratuberculosis were compared to responses by M. bovis-infected cattle. Responses to heterogeneous mycobacterial antigens (i.e., purified protein derivatives [PPDs] and whole-cell sonicates [WCSs]) were also evaluated. Tumor necrosis factor alpha (TNF-α), IFN-γ, and nitric oxide responses by M. bovis-infected cattle to rESAT-6:CFP-10 exceeded (P < 0.05) the corresponding responses by cattle naturally sensitized to M. avium. Experimental infection with M. bovis, M. avium, or M. avium subsp. paratuberculosis induced significant (P < 0.05) IFN-γ and nitric oxide production to WCS and PPD antigens, regardless of the mycobacterial species used for the preparation of the antigen. Responses to homologous crude antigens generally exceeded responses to heterologous antigens. Nitric oxide and IFN-γ responses to rESAT-6:CFP-10 by blood leukocytes from M. bovis-infected calves exceeded (P < 0.05) the corresponding responses of noninfected, M. avium-infected, and M. avium subsp. paratuberculosis-infected calves. Despite the reported potential for secretion of immunogenic ESAT-6 and CFP-10 proteins by M. avium and M. avium subsp. paratuberculosis, it appears that use of the rESAT-6:CFP-10 fusion protein will be useful for the detection of tuberculous cattle in herds with pre-existing sensitization to M. avium and/or M. avium subsp. paratuberculosis.
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Laranja-da-Fonseca, Luis Femando, Alexandre Azevedo Oliva, Christian Campos Pereira, and Marcos Veiga dos Santos. "Doença de Johne: uma doença emergente em rebanhos leiteiros brasileiros." Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP 3, no. 2 (July 1, 2000): 30–39. http://dx.doi.org/10.36440/recmvz.v3i2.3336.

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A Paratuberculose ou Doença de Johne é uma doença infecto-contagiosa, causada pelo Mycobacterium paratuberculosis, que se caracteriza por um processo inflamatório granulomatoso no intestino dos ruminantes domésticos e selvagens, determinando redução na digestibilidade dos alimentos, com consequente queda na produção de leite. Os animais infectados geralmente apresentam diarreia progressiva e perda de peso, Ainda que a literatura nacional apresente descrições da ocorrência de paratuberculose como casos isolados, não existem dados sobre a ocorrência da paratuberculose em rebanhos leiteiros no Brasil. Em estudo recente que avaliou a presença de anticorpos anti-M. paratuberculosis em rebanhos leiteiros do Estado de São Paulo, LARANJA-DA-FONSECA et al. (1999) identificaram que dos 403 animais amostrados, 153 (37,9%) apresentaram anticorpos anti-Mycobacterium paratuberculosis e, das 20 fazendas amostradas, 19 (95%) tiveram pelo menos um animal positivo, existindo assim a necessidade de levantamentos epidemiológicos da doença, afim de que se possa avaliar o real impacto da paratuberculose nos rebanhos brasileiros.
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Ionina, S. V. "Cultivation of mycobacterium paratuberculosis." Siberian Herald of Agricultural Science 49, no. 2 (May 22, 2019): 64–69. http://dx.doi.org/10.26898/0370-8799-2019-2-8.

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The paper presents a new solid growth medium for the cultivation of Mycobacterium paratuberculosis consisting of organic and inorganic ingredients. The study of diagnostic informative value and effectiveness of solid growth media used for cultivation of Mycobacterium Paratuberculosis was carried out in the laboratory conditions. Extract from birch-wood ash of 3% concentration and a growth stimulant of biological origin, peat oxide, were introduced as a mineral salt bases into the developed medium. When constructing the test medium, Lоwenstein–Jensen egg growth medium with the addition of mycobactin, which is an extract from Mycobacterium. phlei and contains substances necessary for the nutrition and reproduction of Mycobacterium paratuberculosis on artificial nutrient media, was used as an analogue. A test on compatibility and solubility of the components was done in distilled water in accordance with the generally accepted guidelines. The duration of observation ranged from 60 to 90 days. A comparison was made between the time of appearance of the primary and intensive growth of mycobacteria of paratuberculosis on the experimental medium and the Lоwenstein–Jensen control medium with mycobactin. Colonies of primary and intensive growth of standardized M. paratuberculosis strain and M. paratuberculosis isolate obtained from the cattle biomaterial on experimental egg growth medium appeared 3-7 days faster than on Lоwenstein–Jensen control medium with mycobactin. When inoculating biomaterial from cattle (lymph nodes and intestine), the primary growth of M. paratuberculosis on the experimental medium was noted 7 days earlier than on the control one, and the intensive growth was 3 days earlier. The experimental growth medium is cheaper and simpler to prepare than Lоwenstein–Jensen control medium with mycobactin, whose preparation is a rather laborious technological process.
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Paustian, Michael L., Vivek Kapur, and John P. Bannantine. "Comparative Genomic Hybridizations Reveal Genetic Regions within the Mycobacterium avium Complex That Are Divergent from Mycobacterium avium subsp. paratuberculosis Isolates." Journal of Bacteriology 187, no. 7 (April 1, 2005): 2406–15. http://dx.doi.org/10.1128/jb.187.7.2406-2415.2005.

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ABSTRACT Mycobacterium avium subsp. paratuberculosis is genetically similar to other members of the Mycobacterium avium complex (MAC), some of which are nonpathogenic and widespread in the environment. We have utilized an M. avium subsp. paratuberculosis whole-genome microarray representing over 95% of the predicted coding sequences to examine the genetic conservation among 10 M. avium subsp. paratuberculosis isolates, two isolates each of Mycobacterium avium subsp. silvaticum and Mycobacterium avium subsp. avium, and a single isolate each of both Mycobacterium intracellulare and Mycobacterium smegmatis. Genomic DNA from each isolate was competitively hybridized with DNA from M. avium subsp. paratuberculosis K10, and open reading frames (ORFs) were classified as present, divergent, or intermediate. None of the M. avium subsp. paratuberculosis isolates had ORFs classified as divergent. The two M. avium subsp. avium isolates had 210 and 135 divergent ORFs, while the two M. avium subsp. silvaticum isolates examined had 77 and 103 divergent ORFs. Similarly, 130 divergent ORFs were identified in M. intracellulare. A set of 97 ORFs were classified as divergent or intermediate in all of the nonparatuberculosis MAC isolates tested. Many of these ORFs are clustered together on the genome in regions with relatively low average GC content compared with the entire genome and contain mobile genetic elements. One of these regions of sequence divergence contained genes homologous to a mammalian cell entry (mce) operon. Our results indicate that closely related MAC mycobacteria can be distinguished from M. avium subsp. paratuberculosis by multiple clusters of divergent ORFs.
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Rowan, Neil J., Scott J. MacGregor, John G. Anderson, Douglas Cameron, and Owen Farish. "Inactivation of Mycobacterium paratuberculosis by Pulsed Electric Fields." Applied and Environmental Microbiology 67, no. 6 (June 1, 2001): 2833–36. http://dx.doi.org/10.1128/aem.67.6.2833-2836.2001.

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ABSTRACT The influence of treatment temperature and pulsed electric fields (PEF) on the viability of Mycobacterium paratuberculosiscells suspended in 0.1% (wt/vol) peptone water and in sterilized cow's milk was assessed by direct viable counts and by transmission electron microscopy (TEM). PEF treatment at 50°C (2,500 pulses at 30 kV/cm) reduced the level of viable M. paratuberculosis cells by approximately 5.3 and 5.9 log10 CFU/ml in 0.1% peptone water and in cow's milk, respectively, while PEF treatment of M. paratuberculosisat lower temperatures resulted in less lethality. Heating alone at 50°C for 25 min or at 72°C for 25 s (extended high-temperature, short-time pasteurization) resulted in reductions ofM. paratuberculosis of approximately 0.01 and 2.4 log10 CFU/ml, respectively. TEM studies revealed that exposure to PEF treatment resulted in substantial damage at the cellular level to M. paratuberculosis.
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Coussens, Paul M. "Mycobacterium paratuberculosisand the bovine immune system." Animal Health Research Reviews 2, no. 2 (December 2001): 141–62. http://dx.doi.org/10.1079/ahrr200134.

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AbstractMycobacterium aviumsubspeciesparatuberculosis(M. paratuberculosis) is the causative agent of Johne’s disease, a deadly intestinal ailment of ruminants. Johne’s disease is of tremendous economic importance to the worldwide dairy industry, causing major losses due to reduced production and early culling of animals. A highly controversial but developing link between exposure toM. paratuberculosisand human Crohn’s disease in some individuals has led to the suggestion thatM. paratuberculosisis also a potential food safety concern. As with many other mycobacteria,M. paratuberculosisis exquisitely adapted to survival in the host, despite aggressive immune reactions to these organisms. One hallmark of mycobacteria, includingM. paratuberculosis, is their propensity to infect macrophages. Inside the macrophage,M. paratuberculosisinterferes with the maturation of the phagosome by an unknown mechanism, thereby evading the host’s normal first line of defense against bacterial pathogens. The host immune system begins a series of attacks againstM. paratuberculosis-infected macrophages, including the rapid deployment of activated γδ T cells, CD4+T cells and cytolytic CD8+T cells. These cells interact with the persistently infected macrophage and with each other through a complex network of cytokines and receptors. Despite these aggressive efforts to clear the infection,M. paratuberculosispersists and the constant struggle of the immune system leads to pronounced damage to the intestinal epithelial cells. Enhancing our ability to control this important and tenacious pathogen will require a deeper understanding of howM. paratuberculosisinterferes with macrophage action, the cell types involved in the immune response, the cytokines these cells use to communicate, and the host genetic factors that control the response to infection.
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Hostetter, J., R. Kagan, and E. Steadham. "Opsonization Effects on Mycobacterium avium subsp. paratuberculosis-Macrophage Interactions." Clinical Diagnostic Laboratory Immunology 12, no. 6 (June 2005): 793–96. http://dx.doi.org/10.1128/cdli.12.6.793-796.2005.

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ABSTRACT High antibody titers in ruminants infected with Mycobacterium avium subsp. paratuberculosis correlates with disease progression. Effects of humoral responses during mycobacterial infection are not completely understood. This study suggests that activation status may be an important factor in determining macrophage ability to limit proliferation of opsonized M. avium subsp. paratuberculosis.
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Barukcic, Ilija. "Mycobacterium Avium Subspecies Paratuberculosis." Modern Health Science 1, no. 1 (June 12, 2018): p19. http://dx.doi.org/10.30560/mhs.v1n1p19.

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Objective: This systematic review assesses the causal relationship between Mycobacterium avium subspecies paratuberculosis (MAP) and Crohn’s disease (CD). Methods: A systematic review and meat-analysis of some impressive PCR based studies is provided aimed to answer among other questions the following question. Is there a cause effect relationship between Mycobacterium avium subspecies paratuberculosis and Crohn’s disease? The method of the conditio per quam relationship was used to proof the hypothesis whether the presence of Mycobacterium avium subspecies paratuberculosis guarantees the presence of Crohn’s disease. In other words, if Crohn’s disease is present, then Mycobacterium avium subspecies paratuberculosis is present too. The mathematical formula of the causal relationship k was used to proof the hypothesis, whether there is a cause effect relationship between Mycobacterium avium subspecies paratuberculosis and Crohn’s disease. Significance was indicated by a p-value of less than 0.05. Result: The studies analyzed (number of cases and controls N=1076) were able to provide evidence that Mycobacterium avium subspecies paratuberculosis is a necessary condition (a conditio sine qua non) and sufficicent conditions of Crohn’s disease. Furthermore, the studies analyzed provide impressive evidence of a cause-effect relationship between Mycobacterium avium subspecies paratuberculosis and Crohn’s disease. Conclusion: Mycobacterium avium subspecies paratuberculosis is the cause of Crohn’s disease (k=+0,377468824, p value < 0.0001).
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Dupont, Chris, Keith Thompson, Cord Heuer, Brigitte Gicquel, and Alan Murray. "Identification and characterization of an immunogenic 22 kDa exported protein of Mycobacterium avium subspecies paratuberculosis." Journal of Medical Microbiology 54, no. 11 (November 1, 2005): 1083–92. http://dx.doi.org/10.1099/jmm.0.46163-0.

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An exported 22 kDa putative lipoprotein was identified in an alkaline phosphatase gene fusion library of Mycobacterium avium subsp. paratuberculosis and expressed in Mycobacterium smegmatis. The full nucleic acid sequence of the gene encoding P22 was determined and the ORF was cloned into a mycobacterial expression vector, enabling full-length P22 to be produced as a C-terminal polyhistidine-tagged protein in M. smegmatis. N-terminal sequencing of the recombinant protein confirmed cleavage of a signal sequence. Native P22 was detected in culture supernatants and cell sonicates of M. avium subsp. paratuberculosis strain 316F using rabbit antibody raised to recombinant P22. Investigation of the presence of similar genes in other mycobacterial species revealed that the gene was present in Mycobacterium avium subsp. avium and similar genes existed in Mycobacterium intracellulare and Mycobacterium scrofulaceum. Database searches showed that P22 belonged to the LppX/LprAFG family of mycobacterial lipoproteins also found in Mycobacterium leprae and in members of the Mycobacterium tuberculosis complex. P22 shared less than 75 % identity to these proteins. Recombinant P22 was able to elicit interferon-gamma secretion in blood from eight of a group of nine sheep vaccinated with a live attenuated strain of M. avium subsp. paratuberculosis (strain 316F) compared to none from a group of five unvaccinated sheep. Antibody to P22 was detected by Western blot analysis in 10 out of 11 vaccinated sheep, in two out of two clinically affected cows and in 11 out of 13 subclinically infected cows.
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Dissertations / Theses on the topic "Mycobacterium paratuberculosis"

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Chastel, Michaël Foucras Gilles. "Épidémiologie de la paratuberculose des ruminants conséquences sur les mesures de contrôle et de prévention /." [S.l.] : [s.n.], 2008. http://oatao.univ-toulouse.fr/2081/1/debouch_2081.pdf.

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Mathie, Heather. "Early macrophage response to Mycobacterium avium subspecies paratuberculosis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31378.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic enteritis that has a damaging economic and welfare impact on the livestock industry. Johne's disease in cattle is known to reduce milk yield and carcass value, making it of economic concern to both dairy and beef farmers. In addition, there is cause for concern regarding zoonotic transmission, as there is an unconfirmed but potential relationship between MAP infection and human Crohn's disease, which presents similar clinical symptoms. MAP is most often contracted by neonates through the faecal-oral route, but can also be spread through contact with contaminated milk and colostrum, as well as in utero. Once the host receives an oral dose, the bacteria traverse the gut epithelium and are phagocytosed by gut macrophages residing in the lamina propria and Peyer's patches. MAP are able to evade the macrophage response by resisting intracellular degradation within phagosomes. Infected macrophages respond to the infection by secreting several pro-inflammatory cytokines that drive the downstream immune response and granuloma formation. This work aimed to elucidate key early responses of bovine monocyte derived macrophages (MDM) to MAP infection, and determine the reliability of using the reference strain, K10 (which is likely to have undergone lab adaptation) to model the infection in vitro, by comparing the MDM response to K10 with the response to a recent clinical isolate, C49. At a multiplicity of infection of 5 (MOI 5), there was a significant decrease in K10 intracellular survival (~90%), compared to C49 intracellular survival, over a 24 hour infection time-course. This suggests that K10 may have lost some virulence mechanism through lab adaptation. Understanding the mechanisms of how MDM respond to these two strains could be informative for the design of targeted vaccines When further investigating the MDM response to both strains, it was found that, at MOI 5, MDM infected with K10 secreted higher levels of IL-1β and IL-10, compared to MDM infected with C49. Both cytokines are associated with mycobacterial infection and could perhaps indicate that MDM are more responsive to the K10 strain at early time-points. In addition, MDM infected with K10 produced significantly higher levels of reactive nitrogen species (RNS). RNS are antimicrobial products that can destroy invading pathogens, and have been shown to have bactericidal effects on MAP. The production of RNS could, therefore be a potential mechanism by which MDM are able to kill K10 more efficiently than C49. An additional aim of this project was to understand the importance of the route of phagocytosis in determining the outcome of MAP infection. MDM express several phagocytic receptors, including Fc receptors (FcRs), complement receptors (CR), Ctype lectin receptors and scavenger receptors. This project mainly focused on the role of the mannose receptor (MR) on bacterial uptake and downstream immune responses, as past studies have suggested that other species of mycobacteria such as M. tuberculosis, target the mannose receptor in order to regulate macrophage immune responses. Blocking the MR reduced intracellular survival for both strains of MAP; however, the mechanism by which the MR influences intracellular survival remains poorly understood The effect of opsonisation on MAP prior to uptake by phagocytic cells was also investigated, as presence of opsonins, such a complement proteins and antibody, can change the mechanism by which pathogens are phagocytosed. MAP were incubated in serum from either MAP- negative or MAP- positive cattle, prior to infection and the percentage uptake and survival assessed by performing colony counts. Opsonisation in serum from Johne's negative cattle resulted in marked increase in MAP uptake but not intracellular survival, whereas opsonisation in serum from Johne's positive cattle did not increase uptake but decreased the intracellular survival rate by 24 HPI. This finding highlights a potential protective role of antibody early in the infection process, and could significantly impact how the infection is modelled in future, as anti-MAP antibody may be present in contaminated milk at the point of infection. Taken together, the data presented in this thesis show that bacterial strain has a significant impact on MDM response to MAP infection, which may have important implications for the interpretation of previous studies and the design of future studies investigating host-pathogen interactions in the context of paratuberculosis. Additionally, this work has shown that RNS production and the mechanism of uptake can affect intracellular survival rates, and although this needs further investigation, the findings could have implications for the design of future vaccines.
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Marcé, Clara. "Modelling the transmission of and effectiveness of control measures for Mycobacterium avium subsp. Paratuberculosis in dairy herds." Rennes 1, 2010. http://www.theses.fr/2010REN1S047.

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Paratuberculosis is a worldwide incurable disease of ruminants resulting in a decrease in milk production and slaughter value. The aim of this thesis was to evaluate the epidemiological and economic effectiveness of selected control programmes in infected dairy herds. A stochastic simulation model has been developed to represent both the population dynamics within a dairy herd and the transmission of Mycobacterium avium subsp. Paratuberculosis (Map). It has been coupled to an existing bioeconomic model. The spontaneous within-herd progression of Map infection after the introduction of one infected cattle in an initially susceptible herd was studied in the absence of control measure. The effect of within-herd contacts on Map spread in a persistently infected herd was investigated. The cost-effectiveness of test-and-cull strategies to control Map infection in dairy herds was assessed. Simulation outcomes put forward that, even when no control measure is implemented, fadeout can occur if less than two clinically affected animals are present. In persistently infected herds, the two main transmission routes are transmission via the environment of the farm and in utero transmission. Isolating calves from their herd mates during the first weeks of age has no significant impact on Map transmission. Limiting or delaying calf exposure to adult faeces and early culling of clinically affected adults are thus recommended to decrease Map prevalence in infected dairy herds. Systematic test-and-cull appears cost-effective if implemented from the day one infected cattle is introduced. The tool designed here is flexible and enables studying other control options within a dairy herd
La paratuberculose est une maladie incurable des ruminants entraînant une diminution de la production laitière et de la valeur de carcasse des animaux infectés. L'objectif de ma thèse est d'évaluer l'efficacité épidémiologique et économique d'actions de maîtrise en troupeaux bovins laitiers infectés. Un modèle de simulation stochastique représentant la dynamique de population d'un troupeau bovin laitier et la transmission indirecte de Mycobacterium avium subsp. Paratuberculosis (Map) a été, élaboré puis couplé à un simulateur bioéconomique existant. L'évolution spontanée de l'infection après I'introduction d'un animal infecté dans un troupeau initialement sensible est étudiée en l'absence d'action de maîtrise. L'effet de la structure de contact sur la transmission de Map est exploré. La rentabilité de stratégies de maîtrise de l'infection est évaluée. Une extinction de l'infection peut survenir lorsque moins de deux animaux cliniquement infectés sont présents en cinq ans, en l'absence d'action de maîtrise. Dans les troupeaux infectés persistants, la transmission in utero et via l'environnement contaminé sont les deux principales voies de transmission. Empêcher le contact précoce entre veaux n'a pas d'impact sur la transmission de Map. Il est recommandé de limiter ou retarder l'exposition des veaux aux fèces des adultes et de réformer rapidement les animaux cliniquement infectés pour réduire la prévalence de l'infection. L'utilisation de tests suivis de réformes mis en place systématiquement dès l'introduction d'un animal infecté semble rentable. L'outil développé ici est flexible et permettra d'étudier d'autres actions de maîtrise en troupeau laitier
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Millar, Douglas Spencer. "Mycobacterium paratuberculosis, mycobacteria and chronic enteritis in humans and animals." Thesis, St George's, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308932.

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Bulander, Korinna. "Vergleichende Untersuchungen zum Nachweis von Mycobacterium avium ssp. paratuberculosis in Milchrinderbeständen." Giessen VVB Laufersweiler, 2009. http://d-nb.info/995997667/04.

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Okafor, Chika Chukwunonso. "Detection of Mycobacterium avium subsp. paratuberculosis IgG by a conductometric biosensor an aid in diagnosis of Johne's disease /." Diss., Connect to online resource - MSU authorized users, 2008.

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Elze, Julia. "Nachweis von Mycobacterium avium ssp. paratuberculosis bei Schlachtrindern." Hannover Bibliothek der Tierärztlichen Hochschule Hannover, 2010. http://d-nb.info/1000021831/34.

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Schulze, Martina. "Untersuchungen zur Stammdifferenzierung von Mycobacterium avium subsp. paratuberculosis /." Berlin : Mbv, Mensch-und-Buch-Verl, 2009. http://d-nb.info/995894671/04.

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Herthnek, David. "Molecular diagnostic methods for Mycobacterium avium subsp. paratuberculosis : more than a gut feeling /." Uppsala : Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2009. http://epsilon.slu.se/200920.pdf.

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Pillars, Roxanne Bee. "Control strategies for Johne's disease in dairy cattle." Diss., Connect to online resource - MSU authorized users, 2008.

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Thesis (PH.D.)--Michigan State University. Large Animal Clinical Sciences, 2008.
Title from PDF t.p. (viewed on Aug. 28, 2009) Includes bibliographical references (p. 260-281). Also issued in print.
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Books on the topic "Mycobacterium paratuberculosis"

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International Colloquium on Paratuberculosis (8th 2005 Copenhagen, Denmark). Proceedings of the 8th International Colloquium on Paratuberculosis, August 14-18, 2005, Copenhagen, Denmark: A meeting of the International Association for Paratuberculosis, Inc. Madison, WI: International Association for Paratuberculosis, 2005.

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International Colloquium on Paratuberculosis (8th 2005 Copenhagen, Denmark). Proceedings of the 8th International Colloquium on Paratuberculosis, August 14-18, 2005, Copenhagen, Denmark: A meeting of the International Association for Paratuberculosis, Inc. Madison, WI: International Association for Paratuberculosis, 2005.

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International Colloquium on Paratuberculosis (3rd 1991 Orlando, Fla.). Proceedings of the Third International Colloquium on Paratuberculosis: September 28 - October 2, 1991 : a meeting of the International Association for Paratuberculosis, the Orlando Marriott International Drive, Orlando, Florida, U.S.A. Providence, RI: The Association, 1992.

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International Colloquium on Paratuberculosis (7th 2002 Bilbao, Spain). Proceedings of the Seventh International Colloquium on Paratuberculosis. Madison, WI: International Association for Paratuberculosis, 2003.

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International Colloquium on Paratuberculosis (4th 1994 Cambridge, England). Proceedings of the Fourth International Colloquium on Paratuberculosis, July 17-July 21, 1994: A meeting of the International Association for Paratuberculosis, St. John's College, Cambridge, U.K. Rehoboth, MA: International Association for Paratuberculosis, 1995.

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International Colloquium on Paratuberculosis (5th 1996 Madison, Wis.). Proceedings of the fifth International Colloquium on Paratuberculosis, September 29-October 4, 1996: A meeting of the International Associaiton for Paratuberculosis, Madison, Wisconsin, U.S.A. Rehoboth, MA: International Association for Paratuberculosis, 1997.

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Verschoor, Chris P. Unraveling the genetics of bovine Johne's disease. Hauppauge, N.Y: Nova Science Publishers, 2010.

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International Colloquium on Paratuberculosis (6th 1999 Melbourne, Australia). Proceedings of the Sixth International Colloquium on Paratuberculosis, February 14-18, 1999, Melbourne, Australia: A meeting of the International Association for Paratuberculosis. Madison, WI: International Assoc. of Paratuberculosis, 1999.

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National Research Council (U.S.) Committee on Diagnosis and Control of Johne's Disease., ed. Diagnosis and control of Johne's disease. Washington, D.C: National Academies Press, 2003.

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International Colloquium on Paratuberculosis (2nd 1988 Maisons-Alfort, France). Second International Colloquium on Paratuberculosis: September 22 and 23, 1988. Maisons-Alfort, France: Laboratoire central de recherches vétérinaires, 1988.

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Book chapters on the topic "Mycobacterium paratuberculosis"

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Turenne, Christine Y., and David C. Alexander. "Mycobacterium avium complex." In Paratuberculosis: organism, disease, control, 64–75. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0064.

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Bannantine, John P., Yung-Fu Chang, and Vivek Kapur. "Mycobacterium avium Subspecies paratuberculosis." In Genomes of Foodborne and Waterborne Pathogens, 223–35. Washington, DC: ASM Press, 2014. http://dx.doi.org/10.1128/9781555816902.ch15.

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Sanderson, J. D., M. T. Moss, M. L. V. Tizard, and J. Hermon-Taylor. "Mycobacterium Paratuberculosis and Crohn’s Disease." In Is Crohn’s Disease a Mycobacterial Disease?, 46–48. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-1830-9_5.

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Whittington, Richard. "Cultivation of Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 266–304. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0266.

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Rathnaiah, Govardhan, Fernanda M. Shoyama, Evan P. Brenner, Denise K. Zinniel, John P. Bannantine, Srinand Sreevatsan, Ofelia Chacon, and Raúl G. Barletta. "Molecular genetics of Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 92–103. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0092.

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Bannantine, John P., and Vivek Kapur. "Proteins and antigens of Mycobacterium avium subsp. Paratuberculosis." In Paratuberculosis: organism, disease, control, 104–19. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0104.

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Fox, Naomi J., Lesley A. Smith, Karen Stevenson, Ross S. Davidson, Glenn Marion, and Michael R. Hutchings. "Infection of non-ruminant wildlife by Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 200–212. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0200.

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Grant, Irene R. "Mycobacterium avium subsp. paratuberculosis in animal-derived foods and the environment." In Paratuberculosis: organism, disease, control, 14–28. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0014.

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Stevenson, Karen, and Christina Ahlstrom. "Comparative genomics and genomic epidemiology of Mycobacterium avium subsp. paratuberculosis strains." In Paratuberculosis: organism, disease, control, 76–91. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0076.

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Coussens, Paul, Justin L. DeKuiper, Fernanda M. Shoyama, Evan Brenner, Elise A. Lamont, Edward Kabara, and Srinand Sreevatsan. "Host-pathogen interactions and intracellular survival of Mycobacterium avium subsp. paratuberculosis." In Paratuberculosis: organism, disease, control, 120–38. Wallingford: CABI, 2020. http://dx.doi.org/10.1079/9781789243413.0120.

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Conference papers on the topic "Mycobacterium paratuberculosis"

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Jiang, Xiu-Yun, Chun-Fang Wang, Fan-Li Zeng, Yu-Qing Hu, Xin-Yu Liu, Hao-Ran Ning, and Zhao-Yang He. "Cloning and Expression of 34KDa Protein Gene of Mycobacterium paratuberculosis in Escherichia coli." In 2010 4th International Conference on Bioinformatics and Biomedical Engineering (iCBBE). IEEE, 2010. http://dx.doi.org/10.1109/icbbe.2010.5515315.

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Liu, Xinyu, Chunfang Wang, Fanli Zeng, Lei Liu, Xiaoai Zhu, Yanhong Dong, Xiuyun Jiang, et al. "Notice of Retraction: Prokaryotic Expression and Analysis on the 22kDa Protein Gene of Mycobacterium paratuberculosis." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780043.

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Seehusen, F., and S. Scherrer. "Ein neuer S-Stamm von Mycobacterium avium subsp. paratuberculosis bei Ziegen in Graubünden – eine morphologische und molekulare Charakterisierung." In 62. Jahrestagung der Fachgruppe Pathologie der Deutschen Veterinärmedizinischen Gesellschaft. Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-1688584.

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Becher, Gunther, Roman Purkhart, Werner Schüler, Heike Köhler, and Petra Reinhold. "Highly specific differentiation ofmycobacterium avium subspec. paratuberculosis(MAP) in comparison to other mycobacteria using GC IMS-spectral analysis from headspace." In Annual Congress 2015. European Respiratory Society, 2015. http://dx.doi.org/10.1183/13993003.congress-2015.oa3488.

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Reports on the topic "Mycobacterium paratuberculosis"

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Bercovier, Herve, Michael Collins, Aliza Cohen, and Louis Levy. Recognition and Production of Specific Antigens of Mycobacterium Paratuberculosis. United States Department of Agriculture, October 1992. http://dx.doi.org/10.32747/1992.7600056.bard.

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Bercovier, Herve, Raul Barletta, and Shlomo Sela. Characterization and Immunogenicity of Mycobacterium paratuberculosis Secreted and Cellular Proteins. United States Department of Agriculture, January 1996. http://dx.doi.org/10.32747/1996.7573078.bard.

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Our long-term goal is to develop an efficient acellular vaccine against paratuberculosis based on protein antigen(s). A prerequisite to achieve this goal is to analyze and characterize Mycobacterium paratuberculosis (Mpt) secreted and cellular proteins eliciting a protective immune response. In the context of this general objective, we proposed to identify, clone, produce, and characterize: the Mpt 85B antigen and other Mpt immunoreactive secreted proteins, the Mpt L7/L12 ribosomal protein and other immunoreactive cellular proteins, Mpt protein determinants involved in invasion of epithelial cells, and Mpt protein antigens specifically expressed in macrophages. Paratuberculosis is still a very serious problem in Israel and in the USA. In the USA, a recent survey evaluated that 21.6% of the dairy herd were infected with Mpt resulting in 200-250 million dollars in annual losses. Very little is known on the virulence factors and on protective antigens of Mpt. At present, the only means of controlling this disease are culling or vaccination. The current vaccines do not allow a clear differentiation between infected and vaccinated animals. Our long-term goal is to develop an efficient acellular paratuberculosis vaccine based on Mpt protein antigen(s) compatible with diagnostic tests. To achieve this goal it is necessary to analyze and characterize secreted and cellular proteins candidate for such a vaccine. Representative Mpt libraries (shuttle plasmid and phage) were constructed and used to study Mpt genes and gene products described below and will be made available to other research groups. In addition, two approaches were performed which did not yield the expected results. Mav or Mpt DNA genes that confer upon Msg or E. coli the ability to invade and/or survive within HEp-2 cells were not identified. Likewise, we were unable to characterize the 34-39 kDa induced secreted proteins induced by stress factors due to technical difficulties inherent to the complexity of the media needed to support substantial M. pt growth. We identified, isolated, sequenced five Mpt proteins and expressed four of them as recombinant proteins that allowed the study of their immunological properties in sensitized mice. The AphC protein, found to be up regulated by low iron environment, and the SOD protein are both involved in protecting mycobacteria against damage and killing by reactive oxygen (Sod) and nitrogen (AhpC) intermediates, the main bactericidal mechanisms of phagocytic cells. SOD and L7/L12 ribosomal proteins are structural proteins constitutively expressed. 85B and CFP20 are both secreted proteins. SOD, L7/L12, 85B and CFP20 were shown to induce a Th1 response in immunized mice whereas AphC was shown by others to have a similar activity. These proteins did not interfere with the DTH reaction of naturally infected cows. Cellular immunity provides protection in mycobacterial infections, therefore molecules inducing cellular immunity and preferentially a Th1 pathway will be the best candidate for the development of an acellular vaccine. The proteins characterized in this grant that induce a cell-mediated immunity and seem compatible with diagnostic tests, are good candidates for the construction of a future acellular vaccine.
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Karcher, Elizabeth L., Donald C. Beitz, and Judith R. Stabel. Osteopontin Expression in Periparturient Dairy Cows Naturally Infected with Mycobacterium Avium Subsp. Paratuberculosis. Ames (Iowa): Iowa State University, January 2008. http://dx.doi.org/10.31274/ans_air-180814-843.

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Barkan, Daniel, Yung-Fu Chang, Patrick McDonough, Susan Fubini, and Robin Gleed. Identification of virulence-associated genes in Mycobacterium avium subsp. paratuberculosis by mutant-library construction. United States Department of Agriculture, January 2016. http://dx.doi.org/10.32747/2016.7600046.bard.

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Shpigel, Nahum, Raul Barletta, Ilan Rosenshine, and Marcelo Chaffer. Identification and characterization of Mycobacterium paratuberculosis virulence genes expressed in vivo by negative selection. United States Department of Agriculture, January 2004. http://dx.doi.org/10.32747/2004.7696510.bard.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of a severe inflammatory bowel disease (IBD) in ruminants, known as Johne’s disease or paratuberculosis. Johne’s disease is considered to be one of the most serious diseases affecting dairy cattle both in Israel and worldwide. Heavy economic losses are incurred by dairy farmers due to the severe effect of subclinical infection on milk production, fertility, lower disease resistance and early culling. Its influence in the United States alone is staggering, causing an estimated loss of $1.5 billion to the agriculture industry every year. Isolation of MAP from intestinal tissue and blood of Crohn's patients has lead to concern that it plays a potential pathogenic role in promoting human IDB including Crohn’s disease. There is great concern following the identification of the organism in animal products and shedding of the organism to the environment by subclinically infected animals. Little is known about the molecular basis for MAP virulence. The goal of the original proposed research was to identify MAP genes that are required for the critical stage of initial infection and colonization of ruminants’ intestine by MAP. We proposed to develop and use signature tag mutagenesis (STM) screen to find MAP genes that are specifically required for survival in ruminants upon experimental infection. This research projected was approved as one-year feasibility study to prove the ability of the research team to establish the animal model for mutant screening and alternative in-vitro cell systems. In Israel, neonatal goat kids were repeatedly inoculated with either one of the following organisms; MAP K-10 strain and three transposon mutants of K-10 which were produced and screened by the US PI. Six months after the commencement of inoculation we have necropsied the goats and taken multiple tissue samples from the jejunum, ileum and mesenteric lymph nodes. Both PCR and histopathology analysis indicated on efficient MAP colonization of all the inoculated animals. We have established several systems in the Israeli PI’s laboratory; these include using IS900 PCR for the identification of MAP and using HSP65-based PCR for the differentiation between MAV and MAP. We used Southern blot analysis for the differentiation among transposon mutants of K-10. In addition the Israeli PI has set up a panel of in-vitro screening systems for MAP mutants. These include assays to test adhesion, phagocytosis and survival of MAP to/within macrophages, assays that determine the rate of MAPinduced apoptosis of macrophages and MAP-induced NO production by macrophages, and assays testing the interference with T cell ã Interferon production and T cell proliferation by MAP infected macrophages (macrophage studies were done in BoMac and RAW cell lines, mouse peritoneal macrophages and bovine peripheral blood monocytes derived macrophages, respectively). All partners involved in this project feel that we are currently on track with this novel, highly challenging and ambitious research project. We have managed to establish the above described research systems that will clearly enable us to achieve the original proposed scientific objectives. We have proven ourselves as excellent collaborative groups with very high levels of complementary expertise. The Israeli groups were very fortunate to work with the US group and in a very short time period to master numerous techniques in the field of Mycobacterium research. The Israeli group has proven its ability to run this complicated animal model. This research, if continued, may elucidate new and basic aspects related to the pathogenesis MAP. In addition the work may identify new targets for vaccine and drug development. Considering the possibility that MAP might be a cause of human Crohn’s disease, better understanding of virulence mechanisms of this organism might also be of public health interest as well.
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Bradner, Laura K., Judith R. Stabel, Donald C. Beitz, and Suelee Robbe-Austerman. Shedding of Mycobacterium avium subsp. paratuberculosis into Milk and Colostrum of Naturally Infected Dairy Cows over Complete Lactation Cycles. Ames (Iowa): Iowa State University, January 2013. http://dx.doi.org/10.31274/ans_air-180814-118.

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Karcher, Elizabeth L., Donald C. Beitz, and Judith R. Stabel. Parturition Invokes Changes in Peripheral Blood Mononuclear Cell Populations in Holstein Dairy Cows Naturally Infected with Mycobacterium Avium Subsp. Paratuberculosis. Ames (Iowa): Iowa State University, January 2008. http://dx.doi.org/10.31274/ans_air-180814-26.

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Osman, Mohamed, Judith Stabel, Jesse M. Hostetter, Daniel S. Nettleton, and Donald C. Beitz. Probiotic Lactobacillus acidophilus strain NP51® Curtails the Progression of Mycobacterium avium Subspecies paratuberculosis (MAP) Infection in Balb/c mice. Ames (Iowa): Iowa State University, January 2011. http://dx.doi.org/10.31274/ans_air-180814-66.

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Bradner, Laura, Judith R. Stabel, Donald C. Beitz, and Suelee Robbe-Austerman. Optimization of Methods for the Detection of Mycobacterium avium subsp. paratuberculosis in Milk and Colostrum of Naturally Infected Dairy Cows. Ames (Iowa): Iowa State University, January 2012. http://dx.doi.org/10.31274/ans_air-180814-701.

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Osman, Mohamed, Judith Stabel, Jesse M. Hostetter, Daniel S. Nettleton, and Donald C. Beitz. Prevention of Mycobacterium avium Subspecies paratuberculosis (MAP) Infection in Balb/c mice by Feeding Lactobacillus acidophilus Strain NP-51®. Ames (Iowa): Iowa State University, January 2010. http://dx.doi.org/10.31274/ans_air-180814-944.

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