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Dissertations / Theses on the topic 'Mycobacteria'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Nakedi, Kehilwe Confidence. "Comprehensive definition of Ser/Thr/Tyr phosphorylation in mycobacteria: towards understanding reprogramming of normal macrophage function by pathogenic mycobacteria." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29707.

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Mycobacterium tuberculosis, the causative agent for the disease Tuberculosis, is a serious public health problem that is responsible for 1.6 million deaths each year. The WHO’s recent report on Tuberculosis estimates that a third of the world’s population is latently infected with the bacteria, and, of those, 10% will progress to active disease. M. tuberculosis is a successful pathogen mainly due to its ability to adapt and survive in changing environments. It can survive a dormant state with limited metabolic activity during latent infection, while also being able to escape the macrophage and
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2

Hasan, Zehra. "Mycobacterium - host interactions : trafficking of mycobacteria within the host cell." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264976.

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3

Millar, Douglas Spencer. "Mycobacterium paratuberculosis, mycobacteria and chronic enteritis in humans and animals." Thesis, St George's, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308932.

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4

Muhammed, Ameen Sirwan. "Re-evaluation of older antibiotics in the area of resistant mycobacteria." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5058.

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Chez les patients traités par un régime posologique, La concentration sérique moyenne et l'écart type de la concentration SMX était 161,01 ± 69,154 mg/L et de 5,788 ± 2,74 mg/L pour le TMP. La concentration minimale inhibitrice 90% (CMI 90) était de 10 mg/L pour le cotrimoxazole et la sulfadiazine contre Mycobacterium tuberculosis. Toutes les mycobactéries étaient inhibées par 20 mg/L de cotrimoxazole et de sulfadiazine. Les CMI de l'ivermectine contre 13 souches complexe M. tuberculosis ont varié entre 10 et 40 mg/L. En outre, tous isoler M. tuberculosis étaient résistants à la squalamine ave
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5

Coulombe, François. "NOD2 and Mycobacteria." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86837.

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The genus Mycobacterium comprises a variety of highly successful intracellular pathogens. Mycobacterium tuberculosis is the causative agent of tuberculosis (TB) in humans and currently infects one third of the world's population. Mycobacterium avium ssp. paratuberculosis is the established cause of Johne's disease in ruminants and is epidemiologically associated with Crohn's disease (CD) in humans. Both TB and CD are complex genetic diseases for which immunological pathways associated with disease susceptibility or resistance have been identified based on human genetic studies. Common polymorp
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6

Hoza, Abubakar Shaaban. "Molecular characterization of Mycobacterium tuberculosis complex and prevalence of nontuberculous mycobacteria and other potential pathogenic bacteria from Tubercolisis suspents in Northeastern, Tanzania." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-211093.

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Molecular typing is increasingly essential to tuberculosis (TB) control programmes, providing public health practitioners with a tool to characterize transmission patterns, track the emergence and spread of strains of M. tuberculosis complex (MTC) in populations. While molecular typing is already used extensively as a tool for TB control in many developed settings across the globe, its use in resource-poor settings is still limited. Moreover, information on the role, contribution and burden of nontuberculous mycobacteria (NTM) and other pathogens in aetiology of TB-like syndromes is also lacki
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7

Jönsson, Bodil. "Epidemiological and immunological studies of environmental mycobacteria : with focus on Mycobacterium abscessus /." Göteborg : Clinical Bacteriology Section, Dept of Infectious medicine, Sahlgrenska Academy, University of Gothenburg, 2009. http://hdl.handle.net/2077/19060.

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8

Linde, Charlotte M. A. "Defense peptides against Mycobacteria /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-480-5/.

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9

Sherratt, Anna Louise. "Lipid bodies in mycobacteria." Thesis, University of Leicester, 2008. http://hdl.handle.net/2381/30499.

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A survey of clinical samples revealed that LBs are a universal feature of tubercle bacilli in sputum. A number of conditions including hypoxia, Nitric Oxide (NO) exposure, pH, heat and cold shock were shown to promote LB formation in M. tuberculosis in vitro. The formation of LBs in NO exposed M. tuberculosis was shown to correlate with the level of antibiotic tolerance displayed by the population. Antibiotic tolerance was thought to be a result of transitory growth arrest; however attempts to assess the growth status of LB positive M. tuberculosis cells were unsuccessful. The morphology of LB
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10

Mathie, Heather. "Early macrophage response to Mycobacterium avium subspecies paratuberculosis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31378.

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Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of Johne's disease, a chronic enteritis that has a damaging economic and welfare impact on the livestock industry. Johne's disease in cattle is known to reduce milk yield and carcass value, making it of economic concern to both dairy and beef farmers. In addition, there is cause for concern regarding zoonotic transmission, as there is an unconfirmed but potential relationship between MAP infection and human Crohn's disease, which presents similar clinical symptoms. MAP is most often contracted by neonates through the faec
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11

Guhan, N. "Mycobacterium tuberculosis RecA intein, a novel LAGLIDADG homing endonuclease, displays dual target specificity in the presence of alternative cofactors." Thesis, Indian Institute of Science, 2002. https://etd.iisc.ac.in/handle/2005/117.

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Mobile inteins and introns are genetic elements capable of self-propagation by “homing” into host genes and occur in entire taxonomy: eubacteria, eukarya, archaea and viruses. The process of “homing” is promoted by an endonuclease encoded by the open reading frame (ORF) embedded within the genetic element. Homing endonucleases are encoded by group I and group II introns, archaeal introns, inteins, and free standing ORFs. They are believed to play a central role in rearrangement of organelle as well as nuclear genomes. Inteins are genetic elements present within protein-coding genes with dual f
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12

Guhan, N. "Mycobacterium tuberculosis RecA intein, a novel LAGLIDADG homing endonuclease, displays dual target specificity in the presence of alternative cofactors." Thesis, Indian Institute of Science, 2002. http://hdl.handle.net/2005/117.

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Mobile inteins and introns are genetic elements capable of self-propagation by “homing” into host genes and occur in entire taxonomy: eubacteria, eukarya, archaea and viruses. The process of “homing” is promoted by an endonuclease encoded by the open reading frame (ORF) embedded within the genetic element. Homing endonucleases are encoded by group I and group II introns, archaeal introns, inteins, and free standing ORFs. They are believed to play a central role in rearrangement of organelle as well as nuclear genomes. Inteins are genetic elements present within protein-coding genes with dual f
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13

Ghanekar, Kiran. "Transposition of IS6110 in Mycobacteria." Thesis, University of Surrey, 1998. http://epubs.surrey.ac.uk/1034/.

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14

Arnvig, Kristine Bourke. "Transcription of rDNA in mycobacteria." Thesis, Open University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368021.

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15

Bryant, Josephine Maria. "Evolutionary genomics of pathogenic mycobacteria." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708462.

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16

Griffiths, Patricia A. "The resistance of Mycobacterium tuberculosis and other mycobacteria of increasing clinical importance to chemical agents." Thesis, Aston University, 1997. http://publications.aston.ac.uk/10956/.

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Tuberculosis is a major public health problem which has been compounded by the emergence of multi-drug-resistant strains of Myco. tuberculosis (MDR-TB), an increased use of immunosuppressive therapy and increasing numbers of HIV infection. To further complicate the infection control issues, many of the environmentally associated mycobacteria, commonly referred to as opportunistic pathogens, are being incriminated in human infection with increasing frequency. Information is required on the mycobactericidal effectiveness of disinfectants, especially those associated with heat sensitive equipment
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17

Sritharan, Manjula. "Studies in iron metabolism of mycobacteria." Thesis, University of Hull, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278446.

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18

Balhana, Ricardo Jorge de Carvalho. "TetR-type transcriptional regulators of mycobacteria." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559020.

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19

Yim, Chi-ho Howard, and 嚴志濠. "Mechanisms of mycobacteria-induced innate responses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45200981.

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20

Magee, John George. "Clinically significant mycobacteria : classification and identifcation." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283088.

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21

Patel, Sushil. "Molecular typing and identification of mycobacteria." Thesis, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300635.

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22

Dixon, Laura. "Characterisation of gene regulation in mycobacteria." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/19594/.

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This study focuses on the characterisation of gene regulation in mycobacteria in response to various signals within the cell. The regulatory mechanisms explored include two types of protein regulators (cAMP-receptor proteins (CRPs) and CsoR) and an RNA-based method of regulation (a member of the ydaO-type riboswitch). The signals concerned are copper and the small nucleotide molecules cyclic AMP and cyclic di-AMP. The study focuses primarily on the regulation of rpfA, which encodes a resuscitation promoting factor that is involved in resuscitation of Mycobacterium tuberculosis from dormancy. T
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23

Smith, Diane Elizabeth. "Adhesion of Mycobacteria: Capture, Fouling, Aggregation." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1542537888485749.

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24

Röse, Lars. "Role of undecaprenyl phosphokinase in mycobacteria." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2004. http://dx.doi.org/10.18452/15048.

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Die Familie der Mykobakterien setzt sich aus pathogenen und apathogenen Vertretern zusammen. In dieser Arbeit wurden 3 Mitglieder dieser Familie für Untersuchungen herangezogen: ihr prominentester pathogener Vertreter Mycobacterium tuberculosis, der Erreger der Tuberkulose, das als Impfstoff eingesetzte Mycobacterium bovis BCG, das durch Attenuierung aus dem Rindertuberkulose-Erreger Mycobacterium bovis hervorging und das apathogene Bodenbakterium Mycobacterium smegmatis. Ein Schlüssel zum Verständnis der Mykobakterien und speziell ihrer Widerstandsfähigkeit ist die Kenntnis ihrer komplexen Z
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25

Pourahmad, Fazel. "Molecular detection and identification of aquatic mycobacteria." Thesis, University of Stirling, 2007. http://hdl.handle.net/1893/355.

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Mycobacteriosis (fish tuberculosis) is a progressive disease of a wide range of wild and captive marine and freshwater fish species. While Mycobacterium marinum, M. fortuitum and M. chelonae are the most frequently reported species to be involved in the disease, several new mycobacteria species have also recently been implicated. Conventional detection / identification of fish mycobacteria is based on histopathology, culture and biochemical characteristics. In this study complementary molecular approaches were developed to assist in Mycobacterium identification. First, a highly specific and se
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26

Nixon, Gavin James. "Studies in the iron metabolism of mycobacteria." Thesis, University of Hull, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.310267.

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27

Thomas, Nicola Alison. "RecA expression and DNA damage in mycobacteria." Thesis, University College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299376.

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28

Nyinoh, Iveren Winifred. "Molecular investigation of drug synergy in mycobacteria." Thesis, University of Surrey, 2017. http://epubs.surrey.ac.uk/844807/.

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For over 50 years, drug combinations have been the gold standard in the therapy of tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb). Clinically, synergistic combinations of drugs are favoured over monotherapy as they allow the use of lower doses and also suppress the development of drug resistance. However, multiple drug-resistant TB (MDR-TB) is on the rise, and is threatening the effective control of the disease globally. Prior to this thesis, drug synergy studies in mycobacteria have largely been determined empirically with little or no mechanistic understanding of the mechanism
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29

Logan, Erin. "Early-life immunity and susceptibility to Mycobacteria." Doctoral thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29195.

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The naïve and not-yet developed infant immune system exhibits heightened susceptibility to external factors (e.g pathogens), and is shaped by these and others, such as maternal immunity. However, we do not yet fully understand their impact on development of infant immunity. A better understanding of these effects would benefit children world-wide, but especially those in low-middle income countries (LMIC), where increased exposure to pathogens due to poorer living conditions highlights the necessity of robust early-life immunity. Mycobacterium tuberculosis (Mtb) and helminths are pathogens co-
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30

Ditse, Zanele. "Replication fidelity in the mircroevolution of mycobacteria." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15541.

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This thesis aimed to elucidate the structure-function relationships determining the differential fidelities of the dnaE1- and dnaE2-encoded mycobacterial PolIIIα subunits under conditions of genotoxic stress. To this end, the role in DnaE1 intrinsic fidelity of highly conserved PHP domain residues was explored by site-directed replacement of targeted amino acids, resulting in a panel of Mycobacterium smegmatis mutants carrying selected dnaE1 alleles. A complementary approach investigated the contribution of the mycobacterial proofreading DnaQ subunit homolog to the maintenance of DnaE1-depend
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31

Shey, Muki Shehu. "Determinants of innate immune responses to mycobacteria." Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/10986.

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Includes bibliographical references.<br>Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the subsequent adaptive responses generated. Our aims were to determine maturational changes in innate immune responses to mycobacteria over the first 9 months of life, and to assess effects of genetic variations in toll-like receptors on host responses to mycobacteri
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32

Collins, Cathleen A. "Ubiquitin in host defense against pathogenic mycobacteria." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3359543.

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33

Baron, Vincent. "Phenotypic discrimination of Mycobacterium tuberculosis by Raman spectroscopy." Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/16562.

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TB remains a major health issue worldwide causing around 1.5 deaths each year. The recent phase III clinical trials of shortened TB treatment failed to show superiority compared to the current regimen and this mainly because of relapse. Relapse is thought to be caused by dormant bacteria. Dormancy in Mycobacterium species has been shown to be associated with the accumulation of intracellular lipids, defining two phenotypes: the lipid rich (LR) cells (associated with dormancy) and the lipid poor (LP) cells (non-dormant). LR cells were shown to have a higher phenotypic antibiotic resistance comp
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34

Taylor, Robert Henry. "Disinfectant Susceptibility of Mycobacterium avium." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/36018.

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<p> Mycobacterium avium, an opportunistic human pathogen, infects between 25 and 50% of advanced-stage acquired immuno-deficiency syndrome (AIDS) patients in the United States. M. avium has been isolated from many environmental sources including: natural waters, soils, and aerosols. M. avium has also been recovered from within municipal and hospital drinking water systems. Rhesus macaques (Macaca mulatta) infected with the simian HIV analog, SIV, have been shown to acquire M. avium infections from potable water. </p><p> Reduced-aggregate fractions (cell suspensions free of large aggregates)
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35

Gcebe, Nomakorinte. "The occurrence and molecular characterization of non-tuberculous mycobacteria in cattle, African buffalo (Syncerus caffer) and their environments in South Africa and genomic characterization and proteomic comparison with Mycobacterium bovis." Thesis, University of Pretoria, 2015. http://hdl.handle.net/2263/58682.

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The aim of this study was to investigate the diversity and prevalence of non-tuberculous mycobacteria (NTM) in cattle, African buffaloes and their environments in South Africa and the potential of these NTM to elicit cross- reactive immune responses in these animal species which may in turn lead to false diagnosis of bovine tuberculosis. A total of 40 NTM species were identified during a countrywide survey. Mycobacterium terrae, Mycobacterium nonchromogenicum, Mycobacterium vaccae/ Mycobacterium vanbaalenii and a group of isolates closely related to Mycobacterium moriokaense (M. moriokaense-li
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36

Wolff, Kerstin Andrea. "A ROLE FOR PROTEIN KINASE G IN FOLATE METABOLISM AND INTRACELLULAR SURVIVAL IN MYCOBACTERIA." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1322846033.

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37

Gomez, Lopez Arley. "Phopholipase c and hemolysis in non-tuberculous mycobacteria." Doctoral thesis, Universite Libre de Bruxelles, 2000. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211690.

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38

Buijtels, Petronella Catharina Adriana Maria. "Clinical relevance of non-tuberculous mycobacteria in Zambia." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10648.

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39

Bhakta, Sanjib. "Endogenous role of arylamine N-acetyltransferase in mycobacteria." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418565.

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40

區建兒 and Kin-yi Au. "HIV Tat and mycobacteria-induced innate immune responses." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hdl.handle.net/10722/193389.

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Acquired Immunodeficiency Syndrome (AIDS) and tuberculosis (TB) have posed diagnostic and therapeutic challenges globally. Nowadays, it is estimated that 34 millions people are living with Human Immunodeficiency Virus (HIV). About 2 millions of people die from AIDS-related causes currently in each year. Tuberculosis is the most common presenting illness and leading cause of death among AIDS patients. Emerging studies suggest that HIV and Mycobacterium tuberculosis (Mtb), the causative pathogen of TB, act synergistically to accelerate decline of immune functions and cause the death. Mtb infe
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41

Dellagostin, Odir Antonio. "Cloning and expression of foreign genes in mycobacteria." Thesis, University of Surrey, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308440.

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42

Vijay, Srinivasan. "Ultrastructural and Molecular Analyses of the Unique Features of Cell Division in Mycobacterium Tuberculosis and Mycobacterium Smegmatis." Thesis, 2013. http://etd.iisc.ernet.in/2005/3403.

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The Mycobacterium genus contains major human pathogens, like Mycobacterium tuberculosis and Mycobacterium leprae, which are the causative agents of Tuberculosis and Leprosy, respectively. They have evolved as successful human pathogens by adapting to the adverse conditions prevailing inside the host, which include host immune activation, nutrient depletion, hypoxia, and so on. During such adaptation for the survival and establishment of persistent infection inside the host, the pathogen, like M. tuberculosis, regulates its cell division. It is known that M. tuberculosis enters a state of non-r
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43

Bansal, Kushagra. "Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Induced Expression Of Cyclooxygenase-2 : Implications For Immune Evasion Strategies." Thesis, 2010. https://etd.iisc.ac.in/handle/2005/2392.

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Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Protective immunity against pathogenic mycobacteria depends principally on cell-mediated immunity executed by efficient anti-infectious functions of type 1 T helper (Th1) subset of CD4+ T cells. The polarization of Th1 responses is orchestrated by IL-12 secreted by antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs). A hallmark of Th1 type CD4+ T cells is the production of IFN-γ that activates plethora of innate cell-mediated immunity. It is well
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44

Bansal, Kushagra. "Mechanistic And Functional Insights Into Mycobacterium Bovis BCG Induced Expression Of Cyclooxygenase-2 : Implications For Immune Evasion Strategies." Thesis, 2010. http://etd.iisc.ernet.in/handle/2005/2392.

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Mycobacteria are multifaceted pathogens capable of causing both acute disease as well as an asymptomatic latent infection. Protective immunity against pathogenic mycobacteria depends principally on cell-mediated immunity executed by efficient anti-infectious functions of type 1 T helper (Th1) subset of CD4+ T cells. The polarization of Th1 responses is orchestrated by IL-12 secreted by antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs). A hallmark of Th1 type CD4+ T cells is the production of IFN-γ that activates plethora of innate cell-mediated immunity. It is well
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45

Matange, Nishad. "Moonlighting Functions of the Rv0805 Phosphodiesterase from Mycobacterium Tuberculosis." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3424.

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All organisms must sense and respond to their environment in order to survive. The processes that allow a living cell to sense changes in its environment, and respond appropriately are collectively referred to as ‘signal transduction’. Cyclic AMP is a ubiquitously used second messenger molecule that plays diverse roles from hormone signalling in mammalian cells to catabolite repression in enteric bacteria. In several bacterial pathogens such as Pseudomonas aeruginosa, cAMP has also been found to mediate pathogenesis, usually by regulating the production of several virulence factors aiding in c
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46

Matange, Nishad. "Moonlighting Functions of the Rv0805 Phosphodiesterase from Mycobacterium Tuberculosis." Thesis, 2013. http://etd.iisc.ernet.in/2005/3424.

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All organisms must sense and respond to their environment in order to survive. The processes that allow a living cell to sense changes in its environment, and respond appropriately are collectively referred to as ‘signal transduction’. Cyclic AMP is a ubiquitously used second messenger molecule that plays diverse roles from hormone signalling in mammalian cells to catabolite repression in enteric bacteria. In several bacterial pathogens such as Pseudomonas aeruginosa, cAMP has also been found to mediate pathogenesis, usually by regulating the production of several virulence factors aiding in c
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47

Vijay, Srinivasan. "Ultrastructural and Molecular Analyses of the Unique Features of Cell Division in Mycobacterium Tuberculosis and Mycobacterium Smegmatis." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3403.

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The Mycobacterium genus contains major human pathogens, like Mycobacterium tuberculosis and Mycobacterium leprae, which are the causative agents of Tuberculosis and Leprosy, respectively. They have evolved as successful human pathogens by adapting to the adverse conditions prevailing inside the host, which include host immune activation, nutrient depletion, hypoxia, and so on. During such adaptation for the survival and establishment of persistent infection inside the host, the pathogen, like M. tuberculosis, regulates its cell division. It is known that M. tuberculosis enters a state of non-r
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48

Jain, Vikas. "Stringent Response In Mycobacteria: Molecular Dissection Of Rel." Thesis, 2006. https://etd.iisc.ac.in/handle/2005/330.

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Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms. Such changes generate a quick and suitable response, which guides the physiology of bacteria. Stringent response is one of the mechanisms that can be called a survival strategy under nutritional starvation in bacteria and was first observed in E. coli upon amino acid starvation, when bacteria demonstrated an immediate downshift in the rRNA and tRNA levels (Stent and Brenner 1961). Mutations that rendered bacteria insensitive to amino acid levels were mapped to an ‘RC gene locus’, later te
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49

Jain, Vikas. "Stringent Response In Mycobacteria: Molecular Dissection Of Rel." Thesis, 2006. http://hdl.handle.net/2005/330.

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Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms. Such changes generate a quick and suitable response, which guides the physiology of bacteria. Stringent response is one of the mechanisms that can be called a survival strategy under nutritional starvation in bacteria and was first observed in E. coli upon amino acid starvation, when bacteria demonstrated an immediate downshift in the rRNA and tRNA levels (Stent and Brenner 1961). Mutations that rendered bacteria insensitive to amino acid levels were mapped to an ‘RC gene locus’, later te
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50

China, Arnab. "Transcription In Mycobacteria : From Initiation To Elongation." Thesis, 2011. https://etd.iisc.ac.in/handle/2005/2423.

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The global re-emergence of TB and other mycobacterial infections have underscored the need for a thorough investigation of the biology of the causative agent, Mycobacterium tuberculosis, at the molecular level. The peculiar features of the bacterium such as slow growth rate, dormancy, unique cell wall composition and resistance towards phagocytosis by macrophages demands a detailed understanding of different essential molecular processes including transcription in this genus. Sequencing of several mycobacterial genomes provided an impetus for understanding the gene function and regulation of t
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