Dissertations / Theses on the topic 'Myalgic encephalomyelitis'
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Wolfe, Patricia Jean de. "I'm really ill, I've got M.E. : bodily disorder and the quest for disease." Thesis, Goldsmiths College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298292.
Full textDe, Wolfe Patricia Jean. "'I'm really ill, I've got M.E.' : bodily disorder and the quest for the disease." Thesis, Goldsmiths College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287740.
Full textHorton-Salway, Mary. "Mind and body in the discursive construction of M.E.: a struggle for authorship of an illness." Thesis, Loughborough University, 1998. https://dspace.lboro.ac.uk/2134/6982.
Full textProcter, Charlotte Anne. "The post-viral fatigue syndrome." Thesis, Durham University, 1990. http://etheses.dur.ac.uk/6221/.
Full textJaffray, Penny. "Society, the body and pain : sociological factors in assessing the meaning and experience of pain in myalgic encephalomyelitis ("yuppie flu") sufferers." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1008381.
Full textGoudsmit, Ellen Marianne. "The psychological aspects and management of chronic fatigue syndrome." Thesis, Brunel University, 1996. http://bura.brunel.ac.uk/handle/2438/4283.
Full textRamsden, Rebecca Mary. "Narratives of partners of individuals affected by Chronic Fatigue Syndrome/Myalgic Encephalomyelitis." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17195.
Full textBarcroft, Rachel. "Chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia : a social model of disability perspective." Thesis, Lancaster University, 2017. http://eprints.lancs.ac.uk/87165/.
Full textHardcastle, Sharni Lee. "Examination of Innate and Adaptive Immune Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients with Varying Degrees of Symptom Severity." Thesis, Griffith University, 2015. http://hdl.handle.net/10072/367042.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
Full Text
Lynch, Sean Patrick Jeremy. "The nature of fatigue in the chronic fatigue syndrome : a longitudinal study." Thesis, Imperial College London, 1996. http://hdl.handle.net/10044/1/7496.
Full textSpencer, Patricia E. "From morphine to milk of magnesia : a case study of children and families living with M.E." Thesis, University of East Anglia, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338040.
Full textPayne, Rosalind. "Narratives of parents living with a child affected by chronic fatigue syndrome/myalgic encephalomyelitis." Thesis, University of Hertfordshire, 2017. http://hdl.handle.net/2299/17472.
Full textMcKay, Pamela Gair. "An exploratory study into the symptoms of chronic fatigue syndrome/myalgic encephalomyelitis and fibromyalgia." Thesis, University of the West of Scotland, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.738487.
Full textWilliams, Deborah Samantha. "Long-term experiences of managing Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) : a qualitative study." Thesis, University of the West of England, Bristol, 2016. http://eprints.uwe.ac.uk/28310/.
Full textStalmeisters, Dzintra. "An investigation into the relationship between early maladaptive schemas and myalgic encephalomyelitis/chronic fatigue syndrome." Thesis, University of Derby, 2012. http://hdl.handle.net/10545/312811.
Full textOsoba, Tolu. "The development of an epidemiological case definition for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)." Thesis, University of the West of England, Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444489.
Full textWhitehead, Lisa. "The lived experience of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) : sufferers' and families' perspectives." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406661.
Full textSolomons, Wendy. "Narratives of young people living with a diagnosis of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)." Thesis, University of Hertfordshire, 2016. http://hdl.handle.net/2299/17597.
Full textLombaard, Ansie. "On the human side... of illness and research." Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/50051.
Full textENGLISH ABSTRACT: This qualitative study comprised an in-depth investigation into the subjective - the explicitly human - experience of those suffering from Myalgic Encephalomyelitis (ME). I was, firstly, concerned with the nature and meaning of the social side of illness, that is, the sufferer's encounters with doctor, family member, friend and acquaintance alike. I was, secondly, set to develop greater insight into the essentially personal experience of being ill. I was able to conclude that, even amidst the inhumane presence of utter ignorance that permeate the very experience of ME, no ME sufferer is inevitably doomed a victim. They can always make a deliberate decision to have a say in their situation, in their own experience of their circumstances. They have the power of personal choice. Recommendations are, therefore, directed at expanding the potential extent and magnitude of this dynamic power. The substantive focus of my study was enriched by a deliberate concern with the methodological implications of my own intimate involvement within the research process. I was here primarily concerned with my personal contribution to the research process as well as the influence thereof on the research relationships developed and the research strategies chosen and applied. I could not but conclude that the understanding I explicate is, as all social science theory, essentially a human construction, developed by me, in my distinctly human capacity. Recommendations are, therefore, geared to sensitise all social researchers to their own contribution to the construction of that which is eventually presented (and taken) as truthful knowl~dge. In conclusion, I am thoroughly convinced that the experience of both illness and research is fundamentally human. This "humanness" cannot and should not be denied. Instead, I advocate a more deliberate focus on the human dimension of illness and research. Without such a focus, a more comprehensive understanding of either realm will continue to linger as but an elusive ideal.
AFRIKAANSE OPSOMMING: Hierdie kwalitatiewe studie is gebaseer op 'n in-diepte ondersoek gerig op die subjektiewe - die onteenseglik menslike - ervaring van diegene wat ly aan Myaligië Enkefalomiëlitis (ME). Ek was, eerstens, geïnteresseerd in die aard en betekenis van die sosiale dimensie van siekte, dit wil sê, die lyer se ervaring van sosiale kontak met dokters, gesinslede, vriende en kennisse. Ek was, tweedens, gerig op die ontwikkeling van 'n grondige insig in die uiters persoonlike ervaring van siek-wees. Ek het tot die gevolgtrekking gekom dat, selfs te midde van die onmenslike teenwoordigheid van blatante onkunde wat die ganse ervaring van ME kenmerk, geen ME lyer noodwendig tot 'n slagoffer-status gedoem is nie. Hulle kan altyd 'n doelbewuste besluit neem om 'n sê te hê in hul eie situasie, in hul eie ervaring van hul omstandighede. Hulle het die mag van persoonlike keuse. Aanbevelings is dus daarop gerig om die potentiële trefwydte en impak van hierdie dinamiese mag uit te brei. Die substantiewe dimensie van my studie is verryk deur 'n doelbewuste fokus op die metodologiese implikasies van my eie intieme betrokkenheid in die navorsingsproses. Ek was hoofsaaklik gemoeid met my persoonlike bydrae tot die navorsingsproses en die invloed daarvan op die ontwikkel van navorsingsverhoudings en die toepassing van gekose navorsingstrategieë. Hierdie fokus het gelei tot die besef dat die beskrywing wat ek aanbied, soos inderdaad alle sosiale teorie, essensieël 'n menslike konstruksie is, soos ontwikkel deur my, in my uitdruklik menslike kapasiteit. Aanbevelings is dus daarop gerig om alle sosiale navorsers te sensitiseer ten opsigte van hul eie bydrae tot die konstruksie van dit wat uiteindelik voorgestel (en geag) word as die waarheidsgetroue kennis. In slotsom, is ek oortuig dat die ervaring van beide siekte en navorsing fundamenteel menslik is. Hierdie "mensheid" kan en behoort nie ontken te word nie. Inteendeel, ek bepleit 'n doelbewuste fokus op die menslike dimensie van siekte en navorsing. Sonder só 'n fokus sal 'n meer diepgaande begrip van iedere area bloot 'n onbereikbare ideaal bly.
Parslow, Roxanne Morin. "Developing a patient reported outcome measure (PROM) for children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715797.
Full textStråhle, Helena. "Autoimmuna aspekter i Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome : En litteraturstudie rörande indikationer på autoimmunitet i ME/CFS." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-96736.
Full textBackground: Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease which is characterized by unexplained and persistent post exertional fatigue (PEM) and a myriad of symptoms related to neurological disturbance, immunological, cognitive and autonomous dysfunction. Despite biomedical research from a disparate field of expertise the pathogenesis and etiology of ME/CFS is not well-understood. Several hypotheses regarding the pathogenesis have been proposed one of which is that ME/CFS is an autoimmune disease. Aim: The purpose of the literature study is to investigate whether there are autoimmune aspects in ME/CFS. Method: A systematic literature study based on scientific articles, published 2010-2020 in the PubMed database. Results: The study results are not entirely consistent when it comes to detecting autoimmune aspects in ME/CFS. Antibody studies targeting neuronal proteins in ME/CFS-patients and antibody treatments, immunoadsorption, and rituximab yielded negative results. In contrast, HSP60 (heat shock protein 60) antibodies for specific cross-reactive epitopes are observed in a subset of ME/CFS patients, which corresponds to infection-triggered autoimmunity. The two gene studies, HLA (human leucocyte antigen) association and genotyping of SNP (single nucleotide polymorphism) in immune genes, observed characteristic risk genes for autoimmune disease. Significant results were observed in ME/CFS- patients with an infection-triggered onset. Conclusion: Despite partially negative results, some support exists for the hypothesis as results indicate autoimmune aspects in ME/CFS with an infection-triggered onset.
Johnston, Samantha Claire. "The Application of the International Consensus Criteria to Assess Prevalence of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis in Australia." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366255.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
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Fellenor, John. "Particular experiences : a psychosocial exploration of myalgic encephalomyelitis (ME) and its relationship with self, environment and the material world." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665427.
Full textKennedy, Alice Catriona. "Exploring the online social identities of people with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) : a discourse analysis approach." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/16296.
Full textHuth, Teilah Kathryn. "Investigation of Cellular and Genetic Mechanisms Required for Natural Killer Cell Cytotoxic Activity in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/366953.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
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Mörk, Camilla, and Dahlberg Linda Welin. "Att leva med myalgisk encefalomyelit." Thesis, Sophiahemmet Högskola, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-3854.
Full textCollatz, Ansel Christina. "Epidemiology of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An Assessment of Case Definitions, Health Related Quality of Life, and Therapeutic Behaviours." Thesis, Griffith University, 2017. http://hdl.handle.net/10072/367802.
Full textThesis (Masters)
Master of Medical Research (MMedRes)
School of Medical Science
Griffith Health
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Gilmour, Robert John. "Qualitative study of individuals' experience of interpersonal relationships before and after the onset of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)." Thesis, University of Leeds, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496128.
Full textMurray, Rebecca E. "A life lived differently : an exploration of how living with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) impacts upon people's identity." Thesis, University of Huddersfield, 2016. http://eprints.hud.ac.uk/id/eprint/31500/.
Full textJohnson, Anne. "Exploring the experiences and occupations of men with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) using a Gadamerian interpretive phenomenological framework." Thesis, University of the West of England, Bristol, 2017. http://eprints.uwe.ac.uk/29916/.
Full textGillings, Kirsty Louise. "The role of cognitive, emotional and behavioural factors in chronic fatigue and chronic fatigue syndrome/myalgic encephalomyelitis : content, process and therapeutic outcome." Thesis, University of Birmingham, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486634.
Full textGyllin, Ann-Charlotte, and Karin Odefjord. "Att vara en åskådare : -Leva med Myalgisk Encefalomyelit/Chronic Fatigue Syndrome." Thesis, Högskolan Väst, Avdelningen för omvårdnad - grundnivå, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-12655.
Full textMaher-Edwards, Lorraine. "The development of a questionnaire to assess metacognition in chronic fatigue syndrome/myalgic encephalomyelitis : the metacognitive beliefs in CFS/ME questionnaire (MB-CFQ)." Thesis, University of East London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.533038.
Full textAndersson, Daniel, and Emma Hellmark. "Arbetsterapeutens roll för personer med diagnosen myalgisk encefalomyelit/kroniskt trötthetssyndrom : En litteraturöversikt." Thesis, Luleå tekniska universitet, Institutionen för hälsovetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-79099.
Full textBackground: ME/CFS is a serious, chronic and complex systemic disease which often and dramatically limits the activity of the affected. The existing scientific evidence of interventions regarding function and disability is limited. The current level of knowledge indicates that the occupational therapist can contribute to the care for people with ME/CFS, but there is a need for further research. Aim: The aim of this literature overview was to map out and describe current research regarding the role of the occupational therapist for people diagnosed with ME/CFS. Method: Data collection for the literature overview was conducted based on developed selection criterias in three relevant databases; PubMed, CINAHL and PsycINFO which resulted in ten articles, seven quantitative and three qualitative studies. The quality of the included studies were assessed and finally a latent content analysis was completed which resulted in four categories. Result: The content analysis resulted in four categories: to supply a client centered support for strategies in activity, to adjust therapeutic approach in occupational adaptation, to consider the therapeutic value of the group treatment, and to contribute to the professional team collaboration. Conclusion: The expertise of the occupational therapist is an important contribution to rehabilitation due to the complex occupational situation for people diagnosed with ME/CFS.
Arnell, Erika, and Lena Höjskeld. "Diagnosen få känner till : Erfarenheter av Myalgisk encefalomyelit/kroniskt trötthetssyndrom." Thesis, Högskolan i Halmstad, Akademin för hälsa och välfärd, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-33801.
Full textMyalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease of unknown etiology. Although ME/CFS is not visible on the outside, it leads to disability in varying degrees. There is a lack of knowledge regarding the disease, which often leads to a delayed or incorrect diagnosis. ME/CFS represents an ethical challenge for research, society and especially for healthcare professionals since no evidence-based nursing or treatment are available. The aim was to investigate people’s experiences with ME/CFS. Three categories emerged in the data analysis: meeting with the health care, impact on daily life and adaption to the new life situation. The result shows experiences of people with ME/CFS and how they feel they are treated by the healthcare system and the lack of knowledge that exists. It appears that the disease affects identity, relationships and abilities in physical activity. The result also shows how life changes and what strategies are required to manage everyday life when the conditions in life change. To meet the nursing needs of people with ME/CFS, more research on the subject, as well as education for healthcare professionals, are necessary.
Nylund, Annika. "De måste åtminstone tro oss : En enkätstudie om hur personer med ME/CFS blir bemötta i primärvården." Thesis, Röda Korsets Högskola, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-2528.
Full textBalinas, Cassandra Z. "Impaired surface expression of Transient Receptor Potential Melastatin 2 and 3 ion channels lowers Natural Killer Cell Cytotoxic Activity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/404161.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
Full Text
Komulainen, Heidi, and Ulrika Sandström. "Kroniskt trötthetssyndrom : en diskursanalys av artiklar 1989-2006." Thesis, Stockholm University, Department of Social Work, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6752.
Full textThe purpose with this work is to describe the language that is built around the chronic fatigue syndrome (CFS) in Sweden. Our questions are: What does the professional field look like; who writes, about what and for which kind of readers? How do they describe the expressions and the upcoming of CFS? For which reasons can CFS be considered as a medical diagnosis/illness? How can CFS be understood from a social perspective? Our theoretical starting point is a social constructive theory and also Karin Johannisson's theory about medicalization and Foucault’s theory about power. We have from a literature-exposition of Swedish articles from 1989 to 2006, done a social constructive discourse analysis with help from Laclau & Mouffe's discourse theory, and Fairclough's model of social practices. In our textual analysis we found three dominating discourses: A medical discourse, a social/cultural discourse and a general/popular discourse. Our results showed that the dominating professional category is doctors and those who have medical direction within their work. In most cases they wrote articles that searched for medical explanations of CFS and their common factor was that they looked at CFS as an illness. The articles that had a social constructive, anthropological, idea historical or religious perspective to CFS was in a minority and they often defined the phenomenon as an expression of different kind of public elements and were often critical to medicalization.
Eaton-Fitch, Natalie R. "Implications of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome on quality of life and the role of transient receptor potential melastatin 3 ion channels on natural killer cells in the pathomechanism of illness." Thesis, Griffith University, 2022. http://hdl.handle.net/10072/415818.
Full textThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Pharmacy & Med Sci
Griffith Health
Full Text
Dardani, Vedije, Sara Lindgren, and Evelina Svensson. ""Vad jag än gör så kostar det..." : Upplevelsen och erfarenheten av ansträngningsutlöst försämring hos personer med Myalgisk Encefalomyelit/Kroniskt Trötthetssyndrom: En empirisk studie baserad på bloggar." Thesis, Jönköping University, HHJ, Avd. för omvårdnad, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-51587.
Full textIntroduction: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized as inflammation of the brain and spinal cord and is characterized above all by persistent fatigue. The disease ME/CFS is not a cultural disease or a local phenomenon and It occurs in various ages, countries and social groups. PEM is characterized by an exacerbation of symptoms after movement, orthostatic or neuromuscular stress and / or cognitive activity. Purpose: The aim of this study was to describe the experiences and the perceptions of post-exertional malaise (PEM) in people with ME/CFS. Method: The study was a qualitative empirical study with a deductive approach based on blogs. Lifeworld was used as a theoretical framework. Result: The results showed that people with ME / CFS described PEM as a stressful and dramatic experience and that constant adjustments were required to avoid this deterioration. The situation was further aggravated by a deficient and unempathetic response in healthcare. Conclusion: Due to abnormal sensitivity to stimuli, each intervention for persons diagnosed with ME / CFS needs to be reflected on whether it is beneficial or harmful. To prevent PEM, healthcare must be adjusted based on the individual effort thresholds of each person. Further research is needed on what improvements are required to ensure high-quality nursing.
Morris, Dorothy, and mikewood@deakin edu au. "Double disability: Lived experience of Australian Tertiary Students with ME/CFS." Deakin University, 2003. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20051110.110308.
Full textMcLoughlin, Pamela Ann. "Have you been walking? : a search for rehabilitation /." View thesis, 1994. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030821.162241/index.html.
Full text"A dissertation submitted in fulfilment of the requirements for the degree of Master of Science (Honours) in Social Ecology in the University of Western Sydney - Hawkesbury" Bibliography : leaves 288-300.
Turner, Laura. "A systematic review of cognitive behavioural therapy (CBT) for the management and treatment of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and Cognitive Behavioural Therapy (CBT) for CFS/ME : an interpretative phenomenological analysis." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6931/.
Full textLundblad, Anette, and Minna Kantola. "Arbetsterapeutiska interventioner för vuxna med ME/CFS och betydelsen för aktivitetsbalans : En litteraturöversikt." Thesis, Luleå tekniska universitet, Hälsa och rehabilitering, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-79451.
Full textTravers, Michele Kerry. "From Violation to Reconstruction: The Process of Self-Renewal Associated with Chronic Fatigue Syndrome." Thesis, The University of Sydney, 2004. http://hdl.handle.net/2123/636.
Full textTravers, Michele Kerry. "From Violation to Reconstruction: The Process of Self-Renewal Associated with Chronic Fatigue Syndrome." University of Sydney. Clinical Nursing, 2004. http://hdl.handle.net/2123/636.
Full textMcLoughlin, Pamela Ann. "Have you been walking?: a search for rehabilitation." Thesis, View thesis, 1994. http://handle.uws.edu.au:8081/1959.7/820.
Full textLUPO, GIUSEPPE FRANCESCO DAMIANO. "RUOLO POTENZIALE DEL MICROBIOMA NELLA SINDROME DA AFFATICAMENTO CRONICO/ ENCEFALOMIELITE MIALGICA (CFS/ME)." Doctoral thesis, Università Cattolica del Sacro Cuore, 2020. http://hdl.handle.net/10280/72840.
Full textThe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), is a severe multisystemic disease characterized by immunological abnormalities and dysfunction of energy metabolism. Recent evidence suggest that there is a strong correlation between dysbiosis and pathological condition. The present research investigated the composition of the intestinal and oral microbiota in CFS/ME patients in comparison to healthy controls and determined whether any observed differences could be useful for the identification of diagnostic biomarkers. The fecal and salivary bacterial composition in CFS/ME patients was investigated by Illumina sequencing of 16S rRNA gene amplicons. The fecal microbiota of CFS/ME patients showed a significant reduction of Lachnospiraceae, particularly Anaerostipes, compared to the non-CFS/ME groups, and an increase of Phascolarctobacterium faecium and unclassified Ruminococcus. Bacteroides vulgatus, unclassified Bacteroides, Bacteroides uniformis and unclassified Barnesiella resulted significantly more abundant in CFS/ME patients. The oral microbiota of CFS/ME patients showed a significant increase of Rothia dentocariosa. The fecal metabolic profile of a subgroup of CFS/ME patients revealed an overall increase of SCFAs and indole derivatives compared to the non-CFS/ME groups, suggesting an increase in the fermentation processes. Our results support the autoimmune hypothesis for CFS/ME condition and if confirmed by larger studies, the differences detected in the microbial profiles of CFS/ME patients may be used as markers for a more accurate diagnosis and for the development of specific therapeutic strategies.
LUPO, GIUSEPPE FRANCESCO DAMIANO. "RUOLO POTENZIALE DEL MICROBIOMA NELLA SINDROME DA AFFATICAMENTO CRONICO/ ENCEFALOMIELITE MIALGICA (CFS/ME)." Doctoral thesis, Università Cattolica del Sacro Cuore, 2020. http://hdl.handle.net/10280/72840.
Full textThe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME), is a severe multisystemic disease characterized by immunological abnormalities and dysfunction of energy metabolism. Recent evidence suggest that there is a strong correlation between dysbiosis and pathological condition. The present research investigated the composition of the intestinal and oral microbiota in CFS/ME patients in comparison to healthy controls and determined whether any observed differences could be useful for the identification of diagnostic biomarkers. The fecal and salivary bacterial composition in CFS/ME patients was investigated by Illumina sequencing of 16S rRNA gene amplicons. The fecal microbiota of CFS/ME patients showed a significant reduction of Lachnospiraceae, particularly Anaerostipes, compared to the non-CFS/ME groups, and an increase of Phascolarctobacterium faecium and unclassified Ruminococcus. Bacteroides vulgatus, unclassified Bacteroides, Bacteroides uniformis and unclassified Barnesiella resulted significantly more abundant in CFS/ME patients. The oral microbiota of CFS/ME patients showed a significant increase of Rothia dentocariosa. The fecal metabolic profile of a subgroup of CFS/ME patients revealed an overall increase of SCFAs and indole derivatives compared to the non-CFS/ME groups, suggesting an increase in the fermentation processes. Our results support the autoimmune hypothesis for CFS/ME condition and if confirmed by larger studies, the differences detected in the microbial profiles of CFS/ME patients may be used as markers for a more accurate diagnosis and for the development of specific therapeutic strategies.
Hart, M. J. Alexandra. "Action in Chronic Fatigue Syndrome: an Enactive Psycho-phenomenological and Semiotic Analysis of Thirty New Zealand Women's Experiences of Suffering and Recovery." Thesis, University of Canterbury. Social and Political Sciences, 2010. http://hdl.handle.net/10092/5294.
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