Academic literature on the topic 'Mutational mechanisms'
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Journal articles on the topic "Mutational mechanisms"
Antić, Željko, Stefan H. Lelieveld, Cédric G. van der Ham, Edwin Sonneveld, Peter M. Hoogerbrugge, and Roland P. Kuiper. "Unravelling the Sequential Interplay of Mutational Mechanisms during Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia." Genes 12, no. 2 (February 2, 2021): 214. http://dx.doi.org/10.3390/genes12020214.
Full textKim, Yoo-Ah, Mark D. M. Leiserson, Priya Moorjani, Roded Sharan, Damian Wojtowicz, and Teresa M. Przytycka. "Mutational Signatures: From Methods to Mechanisms." Annual Review of Biomedical Data Science 4, no. 1 (July 20, 2021): 189–206. http://dx.doi.org/10.1146/annurev-biodatasci-122320-120920.
Full textDunson, David B., and Kenneth R. Tindall. "Bayesian Analysis of Mutational Spectra." Genetics 156, no. 3 (November 1, 2000): 1411–18. http://dx.doi.org/10.1093/genetics/156.3.1411.
Full textRainey, P., and R. Moxon. "Unusual mutational mechanisms and evolution." Science 260, no. 5116 (June 25, 1993): 1958–60. http://dx.doi.org/10.1126/science.8316837.
Full textHurst, L., and A. Grafen. "Unusual mutational mechanisms and evolution." Science 260, no. 5116 (June 25, 1993): 1959–60. http://dx.doi.org/10.1126/science.8316838.
Full textWatson, D. "Unusual mutational mechanisms and evolution." Science 260, no. 5116 (June 25, 1993): 1958–59. http://dx.doi.org/10.1126/science.8391167.
Full textAuerbach, Scott S., Miaofei Xu, B. Alex Merrick, Mark J. Hoenerhoff, Dhiral Phadke, Debra J. Taxman, Ruchir Shah, et al. "Exome Sequencing of Fresh-frozen or Formalin-fixed Paraffin-embedded B6C3F1/N Mouse Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Chemical Exposure." Toxicologic Pathology 46, no. 6 (July 25, 2018): 706–18. http://dx.doi.org/10.1177/0192623318789398.
Full textBalamurugan, Kuppareddi, Martin L. Tracey, Uwe Heine, George C. Maha, and George T. Duncan. "Mutation at the Human D1S80 Minisatellite Locus." Scientific World Journal 2012 (2012): 1–8. http://dx.doi.org/10.1100/2012/917235.
Full textPálinkás, Hajnalka Laura, Lőrinc Pongor, Máté Balajti, Ádám Nagy, Kinga Nagy, Angéla Békési, Giampaolo Bianchini, Beáta G. Vértessy, and Balázs Győrffy. "Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer." International Journal of Molecular Sciences 23, no. 2 (January 6, 2022): 633. http://dx.doi.org/10.3390/ijms23020633.
Full textWalker, Brian A., Christopher P. Wardell, Lorenzo Melchor, Sanna Hulkki, Nicola E. Potter, David C. Johnson, Kerry Fenwick, et al. "Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma." Blood 120, no. 5 (August 2, 2012): 1077–86. http://dx.doi.org/10.1182/blood-2012-03-412981.
Full textDissertations / Theses on the topic "Mutational mechanisms"
Robertson, Scott C. "Mechanisms of protein kinase activation determined by molecular modeling and mutational analysis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9938596.
Full textLegler, Patricia Marie. "Kinetic, magnetic, resonance, and mutational studies of the mechanisms of GDP-mannose mannosyl hydrolase, an unusual nudix enzyme." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3046492.
Full textKennouche, Paul. "New insights into meningococcal pathogenesis : exploring the role of the major pilin PilE in the functions of type IV pili Mechanisms of meningococcal type IV pili multiple functions revealed by deep mutational scanning." Thesis, Sorbonne Paris Cité, 2018. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=1972&f=12515.
Full textType IV pili (TFP) are multifunctional micrometer-long filaments expressed at the surface of many prokaryotes. In Neisseria meningitidis, TFP are homopolymers of the major pilin PilE. They are crucial for virulence as they mediate interbacterial aggregation and adhesion to host cells although the mechanisms behind these functions remain unclear. During this doctoral work, we simultaneously determined the regions of PilE involved in pili display, auto-aggregation and adhesion to human cells by using deep mutational scanning. Mining of this extensive functional map of the pilin sequence provides new mechanistic insights: first, the hyperconserved 1-domain of PilE was found to be involved in the balance between pili length and number; moreover, we identified an electropositive cluster of residues centered around Lysine 140 necessary for aggregation; finally, we show the importance of the tip of TFP in adhesion. Overall, these results support a direct role of PilE in aggregation and adhesion to host cells and identify these specific functional domains. This doctoral work opens up new perspectives on the pathogenicity mechanisms of Neisseria meningitidis and could help design new therapies to fight meningococcal disease
Kugelberg, Elisabeth. "Mechanisms of adaptive mutations in bacteria /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-446-5/.
Full textKitzenmaier, Alexandra [Verfasser], Carmen [Gutachter] Villmann, and Erhard [Gutachter] Wischmeyer. "GlyT2-Mutationen als zweithäufigste Ursache bei Hyperekplexie – Pathologischer Mechanismus der Mutation P429L / Alexandra Kitzenmaier ; Gutachter: Carmen Villmann, Erhard Wischmeyer." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1208629344/34.
Full textSahlin, Charlotte. "Pathogenic Mechanisms of the Arctic Alzheimer Mutation." Doctoral thesis, Uppsala University, Department of Public Health and Caring Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7582.
Full textAlzheimer’s disease (AD) is a progressive neurodegenerative disorder, neuropathologically characterized by neurofibrillay tangles and deposition of amyloid-β (Aβ) peptides. Several mutations in the gene for amyloid precursor protein (APP) cause familial AD and affect APP processing leading to increased levels of Aβ42. However, the Arctic Alzheimer mutation (APP E693G) reduces Aβ levels. Instead, the increased tendency of Arctic Aβ peptides to form Aβ protofibrils is thought to contribute to the pathogenesis.
In this thesis, the pathogenic mechanisms of the Arctic mutation were further investigated, specifically addressing if and how the mutation affects APP processing. Evidence of a shift towards β-secretase cleavage of Arctic APP was demonstrated. Arctic APP did not appear to be an inferior substrate for α-secretase, but the availability of Arctic APP for α-secretase cleavage was reduced, with diminished levels of cell surface APP in Arctic cells. Interestingly, administration of the fatty acid docosahexaenoic acid (DHA) stimulated α-secretase cleavage and partly reversed the effects of the Arctic mutation on APP processing.
In contrast to previous findings, the Arctic mutation generated enhanced total Aβ levels suggesting increased Aβ production. Importantly, this thesis illustrates and explains why measures of both Arctic and wild type Aβ levels are highly dependent upon the Aβ assay used, with enzyme-linked immunosorbent assay (ELISA) and Western blot generating different results. It was shown that these differences were due to inefficient detection of Aβ oligomers by ELISA leading to an underestimation of total Aβ levels.
In conclusion, the Arctic APP mutation leads to AD by multiple mechanisms. It facilitates protofibril formation, but it also alters trafficking and processing of APP which leads to increased steady state levels of total Aβ, in particular at intracellular locations. Importantly, these studies highlight mechanisms, other than enhanced production of Aβ peptide monomers, which could be implicated in sporadic AD.
Segditsas, Stefania. "Mechanisms of intestinal tumorigenesis resulting from APC mutations." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/15923/.
Full textWilliams, Louise Jane. "Recombinational mechanisms in human genetic diversity." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342483.
Full textRobinson, Alexis Anne. "Molecular Mechanisms of DJ-1 Mutations in Parkinson's Disease." Thesis, University College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487292.
Full textRutherford, Jodie. "Germline p53 mutations : characterisation and mechanisms of P53 dysfunction." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252278.
Full textBooks on the topic "Mutational mechanisms"
Elduque, Alberto. Mutations of Alternative Algebras. Dordrecht: Springer Netherlands, 1994.
Find full textGershenson, S. M. Molecular mechanisms of mutagenicity of DNA and other natural and synthetic polynucleotides. Kiev: National Academy of Science of Ukraine, Institute of Plant Physiology and Genetics, 1997.
Find full textHughes, Alis, and Lesley Jones. Pathogenic Mechanisms. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199929146.003.0013.
Full textMendelsohn, Mortimer L. Mutation & The Environment Pt.a: BASIC MECHANISMS (DISCONTINUED (Progress in Clinical and Biological Research)). Edited by Mortimer Mendelsohn. John Wiley & Sons, 1990.
Find full textGrant, Seth G. N. Synaptic Mechanisms of Psychotic Disorders. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0017.
Full textCazeneuve, Cécile, and Alexandra Durr. Genetic and Molecular Studies. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199929146.003.0006.
Full textSun, Warren Da-Ren. Structural, mutational and kinetic analyses of Aquifex aeolicus prephenate dehydrogenase: Elucidation of the catalytic mechanism. 2006.
Find full textPocheville, Arnaud, and Étienne Danchin. Genetic Assimilation and the Paradox of Blind Variation. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199377176.003.0003.
Full textMechanisms in B-cell neoplasia 1994. Berlin: Springer-Verlag, 1995.
Find full textPotter, M., and Michael Potter. Mechanisms in B-Cell Neoplasia 1994. SPRINGER-VERLAG, 1995.
Find full textBook chapters on the topic "Mutational mechanisms"
Barrett, J. Carl. "Asbestos Carcinogenicity: A Mutational Hypothesis." In Mechanisms in Fibre Carcinogenesis, 309–18. Boston, MA: Springer US, 1991. http://dx.doi.org/10.1007/978-1-4684-1363-2_25.
Full textReatégui, Ricardo, Wade Johnson, Wu Xu, Boris Zybailov, Ilya Vassiliev, Gaozhong Shen, John H. Golbeck, and Parag R. Chitnis. "Mutational Analysis of Photosystem I." In Photosynthesis: Mechanisms and Effects, 515–20. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-3953-3_121.
Full textKehrer-Sawatzki, Hildegard, and David N. Cooper. "NF1 Microdeletions and Their Underlying Mutational Mechanisms." In Neurofibromatosis Type 1, 187–209. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-32864-0_14.
Full textGlickman, Barry W., Douglas F. Fix, Fumio Yatagai, Philip A. Burns, and Roel M. Schaaper. "Mechanisms of Spontaneous Mutagenesis: Clues from Mutational Specificity." In Mechanisms of DNA Damage and Repair, 425–37. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4615-9462-8_45.
Full textAsano, Shinji, Tohru Kimura, and Takeguchi Noriaki. "Mutational Analysis of Gastric Proton Pump, α- and β-Subunits." In Mechanisms and Consequences of Proton Transport, 59–70. Boston, MA: Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0971-4_6.
Full textGlickman, Barry W., Philip A. Burns, and Douglas F. Fix. "Mechanisms of Spontaneous Mutagenesis: Clues from Altered Mutational Specificity in DNA Repair-Defective Strains." In Antimutagenesis and Anticarcinogenesis Mechanisms, 259–81. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5182-5_23.
Full textHartman, Philip E., and Sharon Lea Aukerman. "Salmonella Tester Strains: Mutational Targets and Correlation with Animal Carcinogenicity and Teratogenicity." In Mechanisms of DNA Damage and Repair, 407–24. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4615-9462-8_44.
Full textCariello, Neal F., and William G. Thilly. "Use of Gradient Denaturing Gels to Determine Mutational Spectrum in Human Cells." In Mechanisms of DNA Damage and Repair, 439–52. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4615-9462-8_46.
Full textMartinko, John, and Khaled Girgis. "Evidence for Multiple Mutational Mechanisms which Generate Polymorphism at H-2K." In Molecular Evolution of the Major Histocompatibility Complex, 155–61. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84622-9_12.
Full textBurnouf, Dominique, Patrice Koehl, and Robert P. P. Fuchs. "Position of a Single Acetylaminofluorene Adduct Within a Mutational Hot Spot is Critical for the Related Mutagenic Event." In Antimutagenesis and Anticarcinogenesis Mechanisms II, 277–87. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4615-9561-8_23.
Full textConference papers on the topic "Mutational mechanisms"
Nik-Zainal, Serena. "Abstract IA01: Advancing the field of mutational signatures: Mechanisms and clinical applications." In Abstracts: AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; November 2-5, 2016; Montreal, QC, Canada. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1557-3125.dnarepair16-ia01.
Full textSherborne, Amy, Philip Davidson, Katharine Yu, Alice Nakamura, Mamunur Rashid, and Jean Nakamura. "Abstract A50: Mutational analysis of a mouse model of second malignant neoplasms." In Abstracts: AACR Special Conference: Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship; November 9-12, 2015; Fort Lauderdale, Florida. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.pedca15-a50.
Full textJegg, A., TM Ward, E. Iorns, M. Gallas, SA Aparicio, and MD Pegram. "PD01-09: Identifying Novel Mechanisms of Resistance to Lapatinib in ERBB2+ Breast Cancer Cells through Whole Genome Mutational Analysis." In Abstracts: Thirty-Fourth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 6‐10, 2011; San Antonio, TX. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/0008-5472.sabcs11-pd01-09.
Full textPitt, Jason J., Toshio F. Yoshimatsu, Yonglan Zheng, Jason Grundstad, Jigyasa Tuteja, Jiebiao Wang, Abayomi Odetunde, et al. "Abstract 4494: Whole genome sequencing reveals different patterns of mutational mechanisms in breast tumors between women of African and European descent." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4494.
Full textGautieri, Alfonso, Sebastien Uzel, Simone Vesentini, Alberto Redaelli, and Markus J. Buehler. "Osteogenesis Imperfecta: Molecular and Mesoscale Disease Mechanisms." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204530.
Full textEcheverria, Gloria Vittone, Sahil Seth, Zhongqi Ge, Alessandro Carugo, Christopher Bristow, Prabjhot Mundi, Sabrina Jeter-Jones, et al. "Abstract 212: High-resolution barcoding in patient-derived xenografts of triple-negative breast cancer reveals reversible chemoresistance conferred by non-mutational mechanisms." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-212.
Full textWoo, Janghee, Teppei Morikawa, Shuji Ogino, D. Gary Gilliland, and Ramesh A. Shivdasani. "Abstract 3106: Intestinal mesenchymal fibroblasts promote early epithelial tumorigenesis through activation of integrin beta4 and receptor tyrosine kinases, bypassing common mutational mechanisms." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3106.
Full textMontesion, Meagan, Ethan S. Sokol, Todd C. Knepper, Andrew S. Brohl, Garrett M. Frampton, Phil J. Stephens, James A. DeCaprio, Kenneth Y. Tsai, and Lee A. Albacker. "Abstract 4003: Comprehensive genomic profiling of Merkel cell carcinoma samples reveals bimodal distribution of tumor mutational burden and two mutually exclusive candidate mechanisms of malignant transformation." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4003.
Full textMukhopadhyay, Asima, Nicola Curtin, and Richard Edmondson. "Evaluation of different methods to assess homologous recombination status and sensitivity to PARP inhibitors in ovarian cancer." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685289.
Full textYoussoufiän, H., A. Patel, D. Phillips, H. H. Kazazian, and S. E. Antonarakis. "RECURRENT MUTATIONS AND AN UNUSUAL DELETION IN HEMOPHILIA A." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644014.
Full textReports on the topic "Mutational mechanisms"
Walsh, Tomas, and Mary-Claire King. WholeGenome Sequencing of High-Risk Families to Identify New Mutational Mechanisms of Breast Cancer Predisposition. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada613308.
Full textWalsh, Tom, and Mary-Claire King. Whole Genome Sequencing of High-Risk Families to Identify New Mutational Mechanisms of Breast Cancer Predisposition. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada613072.
Full textPetrosino, Joseph F. Mechanisms of Mutation in Non-Dividing Cells. Fort Belvoir, VA: Defense Technical Information Center, May 2002. http://dx.doi.org/10.21236/ada406067.
Full textPetrosino, Joseph F., and Susan Rosenberg. Mechanisms of Mutation in Non-Dividing Cells. Fort Belvoir, VA: Defense Technical Information Center, May 2003. http://dx.doi.org/10.21236/ada416708.
Full textPonder, Rebecca, and Susan Rosenberg. Mechanism of Mutation in Non-Dividing Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2001. http://dx.doi.org/10.21236/ada396622.
Full textPonder, Rebecca G., and Susan Rosenberg. Mechanism of Mutation in Non-Dividing Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2002. http://dx.doi.org/10.21236/ada408728.
Full textPonder, Rebecca G., and Susan Rosenberg. Mechanism of Mutation in Non-Dividing Cells. Fort Belvoir, VA: Defense Technical Information Center, July 2003. http://dx.doi.org/10.21236/ada418965.
Full textSplitter, Gary, and Menachem Banai. Microarray Analysis of Brucella melitensis Pathogenesis. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7709884.bard.
Full textDubeau, Louis. Mechanism of Ovarian Epithelial Tumor Predispostion in Individuals Carrying Germline BRCA1 Mutations. Fort Belvoir, VA: Defense Technical Information Center, January 2005. http://dx.doi.org/10.21236/ada433994.
Full textDubeau, Louis. Mechanism of Ovarian Epithelial Tumor Predisposition in Individuals Carrying Germline BRCA1 Mutations. Fort Belvoir, VA: Defense Technical Information Center, January 2006. http://dx.doi.org/10.21236/ada462015.
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