Relevant bibliographies by topics / Musculo skeletal disorders

Academic literature on the topic 'Musculo skeletal disorders'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Musculo skeletal disorders"

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Silman, A. J. "MUSCULO–SKELETAL DISORDERS IN CHILDHOOD." British Medical Bulletin 42, no. 2 (1986): 196–99. http://dx.doi.org/10.1093/oxfordjournals.bmb.a072122.

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Dodgeon, Jan, and Anne-Marie Dixon. "Work-related Musculo-Skeletal Disorders: An Update." Ultrasound 14, no. 4 (November 2006): 239. http://dx.doi.org/10.1179/174313406x150032.

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Rymaszewski, LA, S. Sharma, PE McGill, A. Murdoch, S. Freeman, and T. Loh. "A team approach to musculo-skeletal disorders." Annals of The Royal College of Surgeons of England 87, no. 3 (May 1, 2005): 174–80. http://dx.doi.org/10.1308/1478708051793.

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Dodgeon, J. R., and A. M. Dixon. "Work-Related Musculo-skeletal Disorders: Call for Guidance." Ultrasound 13, no. 4 (November 3, 2005): 256. http://dx.doi.org/10.1179/174313405x66136.

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Bargiel, Piotr, Norbert Czapla, Jan Petriczko, Daniel Kotrych, Wojciech Zacha, Szczepan Juszkiewicz, Dariusz Lusina, and Piotr Prowanas. "Thermography in the diagnosis of musculo-skeletal disorders." Chirurgia Narządów Ruchu i Ortopedia Polska 83, no. 6 (January 4, 2019): 234–40. http://dx.doi.org/10.31139/chnriop.2018.83.6.46.

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Landau, Kurt, Regina Brauchler, Marianela Diaz-Meyer, Johannes Kiesel, Andreas Lenz, Herwig Meschke, and Angelika Presl. "Occupational stress factors and musculo-skeletal disease in patients at a rehabilitation center." Occupational Ergonomics 10, no. 4 (September 26, 2012): 139–53. http://dx.doi.org/10.3233/oer-2012-0198.

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Disorders of the musculo-skeletal system are one of the main occupational diseases occurring in industrial countries and the number of reported cases is rapidly increasing, especially among the older age groups. Musculo-skeletal diseases can be influenced by a number of stress factors arising during physical work. The aim of this study is to identify the physical work stress factors, to which persons already suffering from musculo-skeletal diseases (patients at a rehabilitation center) have been exposed in their work, and, firstly, to examine whether these data can be used to predict the probability of future musculo-skeletal disorders in workers occupying this type of job, secondly, to determine how these factors interact with each other in the development of these disorders. Trained specialists in occupational medicine using a program called Medical Job-oriented Rehabilitation (MJOR), collected data on 6668 patients by means of a standardized checklist called Bavaria Rehabilitation Assessment Method (BRA). Analysis of the recursive binary partitioning trees revealed that 19 predictor variables corresponding to age and gender, plus repetitive operations, rotation in sedentary position, degree of hand force used and forced head/neck postures were good predictors for the disorders of the hand-/arm system, the cervico-brachial syndrome and the impingement syndrome of shoulder.
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Hori, Katsuo, Naoto Sato, Hisao Takagi, and Akio Inoue. "An experience of F.C.R applied for musculo-skeletal disorders." Orthopedics & Traumatology 39, no. 2 (1990): 659–62. http://dx.doi.org/10.5035/nishiseisai.39.659.

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Dodgeon, Jan, and Ann Newton-Hughes. "Enabling Sonographers to Minimise Work Related Musculo-Skeletal Disorders." BMUS Bulletin 11, no. 3 (August 2003): 16–21. http://dx.doi.org/10.1177/1742271x0301100304.

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B., Kiran, Kala P., Chitra N. S., and Jamuna Rani R. "Comparison of different brands of centrally acting skeletal muscle relaxants: a cost analysis study." International Journal of Basic & Clinical Pharmacology 8, no. 6 (May 23, 2019): 1419. http://dx.doi.org/10.18203/2319-2003.ijbcp20192213.

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Background: Skeletal muscle relaxants are structurally distinct drugs prescribed for reducing muscle spasms, pain, and hyperreflexia. Centrally acting skeletal muscle relaxants are manufactured by various pharmaceutical companies with variable price. The present study, aimed to analyze the cost variation of various brands of centrally acting skeletal muscle relaxants, so as to help the physician to choose the cost effective treatment.Methods: Current index of medical stores (CIMS) April 2018 and online literature were used as information guide to review the prices of drugs used in the treatment of musculo skeletal pain and spastic neurological disorders.Results: Among anti spasmodic group, thiocolchicoside 4 mg shows maximum price variation of 337.5%, whereas carisoprodol 350 mg shows the least variation of 0.1%. It is evident from antispastic group that baclofen 10 mg shows maximum price variation of 93.91% and 5 mg of Baclofen shows the least variation of 11.22%. It is observed that, among anti spastic group, a percentage prize variation of 93.91 for 10 mg and 11.22 for 5 mg baclofen. Largest % prize variation is seen in metaxalone + diclofenac sodium (400+50) mg as 525% and the least variation is observed in tolperisone+ paracetamol (150+325) mg as 3.88%.Conclusions: Centrally acting orally effective skeletal muscle relaxants are commonly prescribed for painful musculoskeletal and spastic neurological disorders. Physicians should give due importance for the cost of the drugs while selecting appropriate drug for musculo skeletal disorders.
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Estryn-Behar, M., M. Kaminski, E. Peigne, M. F. Maillard, A. Pelletier, C. Berthier, M. F. Delaporte, M. C. Paoli, and J. M. Leroux. "Strenuous working conditions and musculo-skeletal disorders among female hospital workers." International Archives of Occupational and Environmental Health 62, no. 1 (January 1990): 47–57. http://dx.doi.org/10.1007/bf00397848.

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Dissertations / Theses on the topic "Musculo skeletal disorders"

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Grilauskienė, Virginija. "Slaugytojų kaulų raumenų sistemos įtampa ir sąsajos su sveikatos sutrikimais." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20050603_115406-66645.

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Musculo – skeletal stress in nursing staff and its association with health disorders Aim of the study was to investigate health complaints and work pressure among nursing staff, and to evaluate the associations of musculo - skeletal stress with their health disorders. Methods. During October - December, 2003, 300 employees of one Kaunas hospital were interviewed. In this case - control study, 100 respondents were included into the case group, and 200 were controls. The main criterion for the selection of controls was no engagement in activities characteristic of a nurse and an assisting nurse. The questionnaire was anonymous. Statistical analysis of the obtained findings was performed using SPSS 12 statistical software package. Results. Nurses whose work was not related to lifting weights (the control group) more frequently complained of pains in the neck (87,5 %), the shoulder girdle (91,7 %), and the back (93,2 %), whereas those whose work was related to lifting weights, more frequently complained of pains around the waist (73,0 %) and in the legs (94,9 %). The study showed that the pain syndrome in the arms by two times more frequently occurred in the control group (12,1 % compared to 6,0 % in the case group), which is characteristic of the sedentary job, especially computer work. Pain syndrome in the legs by four times more frequently occurred in the case group, compared to controls, which is typical of work related to weight lifting. The evaluation of the activities... [to full text]
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Leite, Sheysa Danyelle de Freitas. "Análise dos fatores de risco e do índice de exposição a LER/DORT dos trabalhadores em atividades repetitivas: estudo de caso." Universidade Federal da Paraí­ba, 2013. http://tede.biblioteca.ufpb.br:8080/handle/tede/5263.

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Made available in DSpace on 2015-05-08T14:53:37Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 958288 bytes, checksum: 96e8f893e65870e14e2f18b157219114 (MD5) Previous issue date: 2013-12-30
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
The objective of this study is to analyze the influence of risk factors on exposure to WMSD workers in repetitive activities in the footwear sector. Therefore, we analyzed the data for 71 workplaces in the productive area of a shoe company which are characterized by having a defined task cycle, and had the index of exposure to WMSD upper limbs calculated through the OCRA method. Data analysis was accomplished using the exploratory data analysis of WMSD and construction of a Generalized Linear Model (GLM). This model identified the factors that influence the rate of exposure the most and made it possible to quantify the possible chance of raising this index when risk factors are present in the workplaces. The factor indicated as the most influential one was the "sudden movements" factor, the presence of this factor increases the chance of raising the level of exposure in 2.12 times more than when this factor is not present.
O objetivo deste trabalho foi analisar os fatores de risco e o índice de exposição a LER/DORT dos trabalhadores em atividades repetitivas no setor calçadista.Para tanto foram analisados dados referentes a 71 postos de trabalho da área produtiva de uma empresa calçadista que se caracterizam por possuir um ciclo de tarefa definido, e que tiveram calculados o índice de exposição a LER/DORT nos membros superiores através do método OCRA. O tratamento dos dados foi realizado através da análise exploratória dos dados de LER/DORT e da construção de um Modelo Linear Generalizado (MLG).Este modeloidentificou os fatores que mais influenciam o índice de exposição e possibilitouquantificar a chance de elevação deste índice quando os fatores de risco estão presentes nos postos de trabalho. O fator indicado como o mais influente foi o fator movimentos bruscos , a presença deste fator aumenta a chance de se elevar o índice de exposição em 2,12 vezes a mais do que quando este fator não está presente.
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Simmers, Jessica L. "nNos localization, muscle function and atrophy in skeletal muscle disorders." Thesis, The Johns Hopkins University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3573097.

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In skeletal muscle, loss of neuronal nitric oxide synthase (nNOS) from the sarcolemma has been observed in a few muscular dystrophies and myopathies. However, the extent of this phenomenon, its mechanism, and its physiological impact are not well understood. Using immunofluorescent staining for nNOS, a survey of 161 patient biopsies found absent or reduced sarcolemmal nNOS in 43% of patients. Patient mobility and muscle functional status correlated with nNOS mislocalization from the sarcolemma. Mouse models of inherited and acquired myopathies showed similar loss of sarcolemmal nNOS and impaired mobility and muscle function. A proteomic approach, using mass spectrometry and differentially labeled control and steroid-induced myopathy (SIM) mouse samples, found novel nNOS binding proteins including alpha-actinin-3 (ACTN3), which exhibited decreased interaction with nNOS after steroid treatment. It revealed a potential explanation for impaired muscle function in SIM as nNOS interactions were lost at the sarcomere and gained at the sarcoplasmic reticulum impairing contractility. Treating nNOS-deficient mice with steroids demonstrated that loss of sarcolemmal nNOS reduces muscle contractility and strength in SIM through increased nitric oxide (NO) signaling. In SIM mice treated with a nitric oxide donor and steroids, nitric oxide partially protects the muscle from atrophy and improves muscle fatigability and recovery suggesting nNOS mislocalization also decreases NO availability. These findings show that loss of sarcolemmal nNOS is a common phenomenon that negatively impacts muscle function. Therapeutic strategies targeting nNOS or NO signaling need to allow for the complexity of local nitric oxide content and cellular context.

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Antoun, Ghadi. "Disordered Skeletal Muscle Oxidative Metabolism In Human Obesity and Type 2 Diabetes." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/35184.

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Obesity and type 2 diabetes mellitus (T2DM) are both complex diseases with multifactorial etiologies. Together they affect over 640 million people worldwide and have a significant impact on the global healthcare system incurring costs of over 800 billion dollars. The overall goal of my doctoral research has been to elucidate metabolic predictors and underlying mechanisms in obesity and T2DM. Specifically, I have examined mechanisms contributing to disordered oxidative metabolism in skeletal muscle. My research included participants who were recruited from the Ottawa Hospital Weight Management Clinic in which they completed a clinically supervised meal-replacement and lifestyle intervention program. More so, my doctoral studies evaluated characteristics of muscle mitochondrial function in obesity and T2DM and revealed impaired mitochondrial respiration and electron transport chain supercomplex assembly in muscle from patients with T2DM. The first aim was to study the impact of T2DM on weight loss ability in a large population of obese patients participating in a standardized meal replacement and lifestyle modification program. As there is considerable variability in weight loss propensity, it was found that T2DM significantly deters weight loss although the effect is not large. Since skeletal muscle energetics are central in the development and progression of obesity and T2DM, the second and third aims were to study mitochondrial function in this tissue with the idea of uncovering molecular etiologies. The second aim found deficiencies in mitochondrial respiration in individuals with obesity and T2DM compared to individuals with obesity alone. Reductions in mitochondrial respiration were correlated with increasing levels of HbA1C and attributed to paucity in supercomplex formation in the mitochondrial inner membrane (MIM) of the electron transport chain (ETC). The third aim was to delineate differential fuel oxidation mechanisms and circulating protein biomarkers in obese diet-sensitive (ODS) and obese diet-resistant (ODR) participants following a high fat meal (HFM) challenge. Whole-body analyses were conducted in addition to measures in blood, adipose tissue, skeletal muscle and primary cells. Remarkable increases in oxidative capacity were measured post-HFM. In addition, impaired mitochondrial function was found in the ODR group despite lack of differences in mitochondrial content or the assembly of supercomplexes. Differences were also found in circulating acylcarnitines as well as expression of several proteins including Heat shock 70 kDa protein 1A/1B, Tyrosine-protein kinase Fgr, and Peptidyl-prolyl cis-trans isomerase D. Ultimately, a better understanding of mechanisms involved could lead to significant improvements in personalized medical approaches in obesity and T2DM.
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Bozkurt, Ozlem. "Study Of Bone Characteristics And Muscle Quality In Metabolic Disorders." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614561/index.pdf.

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Although the effects of diabetes on bone mineral content has been studied, little is known about the structural alterations in collagen, maturation of apatite crystals and carbonate content in diabetic bone. The first part of this study aimed to investigate the mineral and organic properties of cortical, trabecular and growth plate regions of rat femur tissues in type I diabetes using FTIR microspectroscopy and Vickers microhardness test. A decrease in mineral content (degree of mineralization), decrease in microhardness, increase in carbonate content, increase in size and maturation of hydroxyapetite crystals, which are the implications of increased osteoporosis, were observed in diabetic bone. In addition, a decreased carbonate substitution into bone apatite and an increase in labile type carbonate was observed in diabetic bone. There was a decrease in the level of crosslinking of collagen in cortical and trabecular regions of diabetic femurs, implying a decrease in bone collagen quality that may contribute to bone fragility. Recent evidence implies that intramyocellular lipid accumulation is directly correlated with insulin resistance, a key parameter in the generation of obesity. The second part of this study is mainly focused on the determination of the structural and compositional characterization of macromolecules of longissimus dorsi and quadriceps muscles of Berlin fat mouse inbred (BFMI) lines using ATR-FTIR spectroscopy and FTIR microspectroscopic imaging, together with the quantification of fiber specific distribution of lipids in these muscles by the use of confocal microscopy. The study groups included 10 weeks old standard breeding diet fed (juvenile) and 20 weeks old high fat diet fed control and BFMI lines. The results revealed the loss of unsaturation in lipids, increased triglyceride content, increased amount of lipids having shorter chain length, increased lipid peroxidation and fiber specific accumulation of lipids in type IIa and intermediate fibers in skeletal muscles of both 10 weeks old and 20 weeks old BFMI lines, emphasizing their obese phenotype. However, the alterations were more prominent in skeletal muscles of 20 weeks old high fat diet fed BFMI lines, displaying a more severe obesity phenotype. The results of the characterization revealed that BFMI860 and BFMI861 lines are convenient models for the study of spontaneous obesity and studies to enlighten the genetic basis of obesity.
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Ferrari, Andrea Lepos. "Adaptação transcultural do questionário \"cultural study of musculo-skeletal and other symptoms and associated disability\" CUPID Questionnaire." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/7/7131/tde-07072009-094358/.

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Este estudo objetivou a adaptação transcultural do questionário Cultural Study of Musculo-Skeletal and Other Symptoms and Associated Disability - CUPID Questionnaire, para a língua portuguesa falada no Brasil e a validação do seu conteúdo. O estudo é do tipo metodológico e foi realizado obedecendo aos procedimentos internacionais recomendados e aos procedimentos específicos indicados pelo autor do Questionário, uma vez que será aplicado em estudo multicêntrico por ele coordenado. A adaptação transcultural foi realizada seguindo as etapas de tradução, retrotradução, avaliação destas versões por um comitê de juízes e pré-teste da versão pré-final. O pré-teste foi realizado no Departamento de Enfermagem do Hospital Universitário da Universidade de São Paulo com 40 trabalhadores de enfermagem. Ajustes foram feitos após a análise das traduções pelo comitê de juízes quando o Índice de Validade de Conteúdo foi inferior a 80%. A versão resultante do questionário foi então pré-testada para verificar a capacidade compreensão e preenchimento pelos sujeitos e a possibilidade de ajustes, considerando o indicativo de ajustes quando 15% destes apresentassem dificuldades em relação ao preenchimento. Os resultados do pré-teste apontam um número significativo de trabalhadores de enfermagem com dores em região lombar, ombro, cotovelo, punho e/ou mão e joelho, associados a sintomas psicossociais e demais incapacidades. A análise das respostas dos sujeitos aos itens do Questionário não evidenciou dificuldades de compreensão e entendimento na totalidade dos itens, indicando a validade de seu conteúdo para a língua portuguesa falada no Brasil. Conclui-se que a versão Brasileira do CUPID Questionnaire é um instrumento adequado para identificar os sintomas musculoesqueléticos, indicados pelos trabalhadores de enfermagem, relacionados às atividades ocupacionais, aspectos psicossociais e outras incapacidades associadas
The objective of this study was to adapt the Transcultural Questionnaire Cultural Study of Muscular-Skeletal and Other Symptoms and Associated Disability CUPID Questionnaire, to the Portuguese language spoken in Brazil and to validate its contents. This methodological study was performed in accordance with internationally recommended procedures and the specific procedures indicated by the Questionnaires author since it will be applied in a multicenter study coordinated by the author. The transcultural adaptation was performed following the steps of translation, back-translation, evaluation of these versions by a committee of judges and pre-test version of the pre-final. The pre-test was performed in the Nursing Department of University Hospital at the University of Sao Paulo with 40 nursing workers. Adjustments were made after an analysis of the translations by a committee of judges when an index of content validation was less than 80%. The resulting version of the questionnaire was then pre-tested to verify the capacity of comprehension and form completion by the subjects and the possibility of adjustments considering an adjustment indicator when 15% of them presented difficulty related to form completion. The results of this pre-test showed that a significant number of Nursing workers complained of pain in the regions of lumbar, shoulder, elbow, wrist and or hand and knee, symptoms associated with psychosocial and other disabilities. Analysis of the subjects responses to items of the questionnaire revealed no difficulty in the comprehension and total understanding of the items indicating a validity of its contents for the Portuguese language spoken in Brazil. It can be concluded that the Brazilian Version of the CUPID Questionnaire is an adequate instrument for the identification of musculoskeletal symptoms indicated by nursing workers related to occupational activities, psychosocial aspects and other associated incapacities
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Brault, Jeffrey J. "Creatine uptake and creatine transporter expression among rat skeletal muscle fiber types." free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091902.

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Caldas, de Almeida Araujo Ericky. "Adaptation of Proof of Concepts Into Quantitative NMR Methods : Clinical Application for the Characterization of Alterations Observed in the Skeletal Muscle Tissue in Neuromuscular Disorders." Phd thesis, Université Paris Sud - Paris XI, 2014. http://tel.archives-ouvertes.fr/tel-01067940.

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Current quantitative nuclear magnetic resonance (NMR) technics offer biomarkers that allow performing non-invasive longitudinal studies for the follow up of therapeutic trials in neuromuscular disorders (NMD). In contrast to fat degeneration, the mechanisms of inflammation/oedema/necrosis and fibrosis are characteristic signs of disease activity, which makes their quantification a promising source of crucial biomarkers for longitudinal studies. This thesis work consisted on the implementation of more precise quantitative NMR methods adapted to the clinical study of skeletal muscle (SKM) for : (i) detection and quantification of sites of disease activity by T2-mapping of muscle water ; (ii) investigation of the different pathophysiological mechanisms underlying T2 alterations ; and (iii) Detection and quantification of muscle fibrosis. We implemented two methods for T2 mapping of muscle water. The first one is based on a multi-spin-echo sequence du type CPMG. In this method the 1H-NMR signals from water and lipids are acquired simultaneously. The acquired data are fitted to a tri-exponential model, in which water and fat signals are separated by exploring the T2 difference between water and fat. This method allows extraction of muscle water T2-value in the presence of fat infiltration. The second method is based on a " partially spoiled steady state free precession " (pSSFP) sequence. In contrast to the first method, which demands a sophisticated post-treatment of images acquired at 17 different echo-times, with the pSSFP a T2-mapping is extracted from two 3D data sets. 3D acquisition is compatible with spectrally selective water excitation, which eliminates signal contribution from lipids. Both methods were validated experimentally on patients and healthy subjects. The results demonstrated their capacity to detect and quantify disease activity sites. This 2 works have been published in two international journals : Azzabou, de Sousa, Araujo, & Carlier, 2014. Journal of Magnetic Resonance Imaging. DOI 10.1002/jmri.24613 (in press); et de Sousa, Vignaud, Araujo, & Carlier . 2012. Magnetic Resonance in Medicine. 67:1379-1390. Although it was shown to reveal disease activity, mono-exponential T2 of muscle water is non-specific to what concerns the mechanisms underlying its alterations. It has been long known that T2 relaxation in SKM tissue is multi-exponential. This is currently accepted to reveal anatomical compartmentation of myowater. We implemented a method for localized spectroscopic CPMG acquisition. CPMG data respect echo-time sampling and signal to noise ration limits for allowing robust multiexponential analysis. This work allowed us to establish a compartmentation model that perfectly explains the multi-exponential T2 relaxation observed in SKM tissue. This work was published in the " Biophysical Journal " (Araujo, Fromes & Carlier 2014. New Insights on skeletal muscle tissue compartments revealed by T2 NMR relaxometry. (In press)). Pilot studies performed in patients show promising results and suggest potential application of the method in clinical studies. Fibrosis starts with an excessive accumulation of intramuscular connective tissue (IMCT). We have explored the " Ultrashort time to echo " (UTE) method with the aim to detect and characterize the signal from IMCT. In a first study we characterized in vivo a short T2 component (~500 µs) in SKM, and we collected evidences suggesting that this component might reflect IMCT. Then we implemented a methodology that allowed imaging this short component in SKM tissue for the first time.
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Araujo, Ericky Caldas de Almeida. "Adaptation of Proof of Concepts Into Quantitative NMR Methods : Clinical Application for the Characterization of Alterations Observed in the Skeletal Muscle Tissue in Neuromuscular Disorders." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112075/document.

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Actuellement, des méthodes quantitatives de résonance magnétique nucléaire (RMN) offrent des biomarqueurs qui permettent la réalisation d’études longitudinales pour le suivi de l’évolution des maladies neuromusculaires et des essais thérapeutiques de manière non-invasive. A la différence de la dégénérescence graisseuse, les processus d’inflammation/œdème/nécrose et fibrose sont des signes d’activité des maladies et leurs quantifications constitueraient ainsi de biomarqueurs parfaitement adaptés pour le suivi thérapeutique. Ce travail de thèse a consisté à mettre en place des méthodologies quantitatives plus précises et adaptées à l’étude clinique du muscle pour : (i) détecter et quantifier des sites d’activité de maladies par la cartographie T2 de l’eau ; (ii) identifier les différents processus pathophysiologiques qui sont à l’origine des altérations du T2 ; et (iii) détecter et quantifier la fibrose musculaire. Nous avons implémenté deux méthodes pour la quantification du T2 de l’eau dans le muscle. La première est basée sur une séquence d’écho de spin du type CPMG, où les signaux provenant des protons des lipides et de l’eau sont acquis simultanément et séparés à postériori par un traitement tri-exponentiel qui exploite la différence entre les T2 qui caractérisent les signaux de l’eau et de la graisse. La deuxième technique est basée sur une séquence de « partially spoiled steady state free precession (pSSFP) ». Différemment de la première technique qui nécessite un traitement assez élaboré sur des images acquises à 17 temps d’écho différents, dans la pSSFP la cartographie T2 est extraite à partir de deux séries de données 3D. L’acquisition 3D est compatible avec des techniques de sélection spectrale de l’eau, ce qui évite la contamination par les signaux des lipides. Les deux méthodes ont été validées expérimentalement chez des malades et des sujets sains et ont démontré leur capacité à détecter et quantifier des sites d’activité de maladies. Ces deux travaux font l’objet de deux publications dans des journaux scientifiques internationaux : Azzabou, de Sousa, Araujo, & Carlier, 2014. Journal of Magnetic Resonance Imaging. DOI 10.1002/jmri.24613 (in press); et de Sousa, Vignaud, Araujo, & Carlier . 2012. Magnetic Resonance in Medicine. 67:1379-1390. Malgré le fait de permettre la détection des sites d’activité de maladies, la mesure mono-exponentielle du T2 de l’eau par imagerie reste non-spécifique vis-à-vis des processus physiologiques à l’origine de l’augmentation du T2. Il est connu que la relaxation T2 du muscle squelettique n’est pas mono-exponentielle. Cela est interprété comme une conséquence de la compartimentation anatomique de l’eau tissulaire. Nous avons mis au point une méthode pour l’acquisition localisée de données CPMG. Cette technique permet l’acquisition des données dans des conditions nécessaires pour la réalisation de traitements multi-exponentiels précis. Ce travail nous a permis d’établir un modèle de compartimentation qui explique parfaitement la relaxation T2 dans le muscle. Il a fait l’objet d’un article publié dans le « Biophysical Journal » (Araujo, Fromes & Carlier 2014. New Insights on skeletal muscle tissue compartments revealed by T2 NMR relaxometry. (In press)). Les essais réalisés chez des sujets malades suggèrent un grand potentiel pour l’application de la méthode dans des études cliniques. La formation de la fibrose commence avec une accumulation excessive de tissu conjonctif intramusculaire (TCIM). Nous avons exploité la technique « Ultrashort Time-to-Echo » (UTE) pour essayer de détecter et caractériser le signal du TCIM. Dans une première étude, nous avons caractérisé in vivo une composante à T2 court (~500 µs) dans le muscle, et nous avons trouvé des indices qui suggèrent qu’elle représente le TCIM. Dans une deuxième étude, nous avons mis au point une méthodologie qui a permis d’imager cette composante à T2 court dans le muscle pour la première fois
Current quantitative nuclear magnetic resonance (NMR) technics offer biomarkers that allow performing non-invasive longitudinal studies for the follow up of therapeutic trials in neuromuscular disorders (NMD). In contrast to fat degeneration, the mechanisms of inflammation/oedema/necrosis and fibrosis are characteristic signs of disease activity, which makes their quantification a promising source of crucial biomarkers for longitudinal studies. This thesis work consisted on the implementation of more precise quantitative NMR methods adapted to the clinical study of skeletal muscle (SKM) for : (i) detection and quantification of sites of disease activity by T2-mapping of muscle water ; (ii) investigation of the different pathophysiological mechanisms underlying T2 alterations ; and (iii) Detection and quantification of muscle fibrosis. We implemented two methods for T2 mapping of muscle water. The first one is based on a multi-spin-echo sequence du type CPMG. In this method the 1H-NMR signals from water and lipids are acquired simultaneously. The acquired data are fitted to a tri-exponential model, in which water and fat signals are separated by exploring the T2 difference between water and fat. This method allows extraction of muscle water T2-value in the presence of fat infiltration. The second method is based on a « partially spoiled steady state free precession » (pSSFP) sequence. In contrast to the first method, which demands a sophisticated post-treatment of images acquired at 17 different echo-times, with the pSSFP a T2-mapping is extracted from two 3D data sets. 3D acquisition is compatible with spectrally selective water excitation, which eliminates signal contribution from lipids. Both methods were validated experimentally on patients and healthy subjects. The results demonstrated their capacity to detect and quantify disease activity sites. This 2 works have been published in two international journals : Azzabou, de Sousa, Araujo, & Carlier, 2014. Journal of Magnetic Resonance Imaging. DOI 10.1002/jmri.24613 (in press); et de Sousa, Vignaud, Araujo, & Carlier . 2012. Magnetic Resonance in Medicine. 67:1379-1390. Although it was shown to reveal disease activity, mono-exponential T2 of muscle water is non-specific to what concerns the mechanisms underlying its alterations. It has been long known that T2 relaxation in SKM tissue is multi-exponential. This is currently accepted to reveal anatomical compartmentation of myowater. We implemented a method for localized spectroscopic CPMG acquisition. CPMG data respect echo-time sampling and signal to noise ration limits for allowing robust multiexponential analysis. This work allowed us to establish a compartmentation model that perfectly explains the multi-exponential T2 relaxation observed in SKM tissue. This work was published in the « Biophysical Journal » (Araujo, Fromes & Carlier 2014. New Insights on skeletal muscle tissue compartments revealed by T2 NMR relaxometry. (In press)). Pilot studies performed in patients show promising results and suggest potential application of the method in clinical studies. Fibrosis starts with an excessive accumulation of intramuscular connective tissue (IMCT). We have explored the « Ultrashort time to echo » (UTE) method with the aim to detect and characterize the signal from IMCT. In a first study we characterized in vivo a short T2 component (~500 µs) in SKM, and we collected evidences suggesting that this component might reflect IMCT. Then we implemented a methodology that allowed imaging this short component in SKM tissue for the first time
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Vieira, Vera Lucia Martinez. "Investigação do acomentimento dos tecidos moles em individuos portadores de disturbios osteomusculares relacionados ao trabalho (DORT)." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310061.

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Orientador: Jose Inacio de Oliveira
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-06T17:45:11Z (GMT). No. of bitstreams: 1 Vieira_VeraLuciaMartinez_D.pdf: 20761528 bytes, checksum: e07d8874c527947dd41ebd43cf4e86a1 (MD5) Previous issue date: 2006
Resumo: A pesquisa teve como objetivo propor um protocolo de investigação de alterações dos tecidos moles, perceptíveis à palpação em pacientes com LER/DORT. A metodologia proposta verificou, por meio de um estudo preliminar, a região a ser avaliada, a demarcação anatômica e o equipamento com especificação a ser utilizado na realização das medidas. Os sujeitos da pesquisa foram selecionados obedecendo a critérios que permitiam a verificação das alterações nos tecidos moles. A população avaliada constituiu-se de 20 homens com média de idade de 41,4 anos, massa corporal média de 76 kg, altura média de 1,71 m e índice de massa corporal (IMC) médio de 26,02 kg/m2; e de 20 mulheres com idade média de 37,9 anos, massa corporal média de 62,7 kg, altura média de 1,64 m e índice de massa corporal (IMC) médio de 23,6 kg/m2. Por meio de técnica palpatória, foi examinada a região do antebraço do membro superior dominante de dez homens e dez mulheres adoecidos com LER/DOR, e dez homens e dez mulheres sem adoecimento no membro superior, porém acometidos de lesão em outra área Os resultados foram submetidos ao cálculo da significância (p < 0,05) e determinou-se a variabilidade das amostras, testando hipóteses. Estes se apresentaram estatisticamente significantes no grupo de mulheres com adoecimento (63 cm) em comparação com as mulheres sem adoecimento (75 cm), mostrando diminuição no deslocamento tecidual na região muscular (terço proximal) do antebraço do membro superior dominante em mulheres com lesão. O fato de se obter resultados significativos no grupo de mulheres suscitou a discussão sobre o adoecimento e suas conseqüências na população trabalhadora feminina. Estudos específicos sobre gênero mostram que os riscos são maiores em mulheres, porém a distribuição da morbidade não está vinculada ao gênero. O experimento visou à elaboração de um protocolo de investigação quantitativa das aderências em tecidos moles e, ainda à comprovação metodológica da coleta desses dados. Porém verificou-se, nos resultados obtidos, possibilidades de se estabelecer parâmetros que possam, de maneira simplificada, mostrar possíveis alterações nos tecidos moles A importância prática desta investigação está na utilidade do dado quantificado para complementar e reafirmar avaliações osteomusculares para fins de diagnósticos de incapacidade em pacientes com LER/DORT. A quantificação pode auxiliar no discernimento subjetivo que envolve a avaliação desses pacientes
Abstract: The research aimed at proposing an investigation protocol for palpable soft tissues in RSI patients Through a preliminary study, the proposed methodology checked the area to be evaluated, the anatomical delimitation of this area as well as the equipment to be used for measurement and specifications. Research subjects were selected pursuant to criteria that allow for the checking of soft tissue abnormalities. The subject population consisted of 20 males averaging 41.4 years of age, 76 kg. body mass average, 1.71 m. average height and average Body Mass Index (BMI) equal to 26.02 kgm2, and 20 females averaging 37.9 years of age, 62.7 kg body mass average, 1.64 m. average height and average Body Mass Index (BMI) equal to 23 6 kgm2 Through palpation technique, the forearm area of the dominant superior limb was examined. The subjects were 10 men and 10 women diagnosed of RSI in the area under scrutiny, and 10 men and 10 women without RSI diagnosis in such area, although injured in other areas. The results were submitted to significance calculation (p < 0.05) and the variability of the samples was determined through hypothesis test These showed to be statistically significant in the positive RSI diagnosis women's group (63 cm) as compared to the healthy women sample (75 cm), the first subjects presenting tissues displacement decrease at the muscle area (proximal third) of the upper limb forearm in positive RSI diagnosis women's group. The issue of significant results having been found in the women's group raised the point of RSI in the female working population. Specific studies on gender show that risks are higher in women, however, the morbidity distribution is not linked to gender. The experiment aimed at preparing a protocol for quantitative investigation of soft tissue adherence and providing methodologic proof of the collection of those data. However, in the obtained results we saw possibilities of establishing parameters that could, in a simplified way, show possible changes in soft tissues. This investigation importance to everyday use is that this quantified datum complements and reasserts osteo-muscular evaluations for disability diagnoses of RSI patients. This quantification may aid to the subjective discernment required to the evaluation of RSI patients
Doutorado
Saude Coletiva
Doutor em Saude Coletiva
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Books on the topic "Musculo skeletal disorders"

1

Stonebrink, Richard D. Evaluation and manipulation management of common musculo-skeletal disorders. [Portland, Ore: Western States Chiropractic College], 1990.

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Stonebrink, Richard D. Evaluation and manipulative management of common musculo-skeletal disorders. 2nd ed. [Portland, Or.?]: R.D. Stonebrink, 1996.

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Parkes, Katharine R. Musculo-skeletal disorders, mental health and the work environment. Sudbury: HSE Books, 2005.

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Page, Frederick T. Occupational groups and the occurrence of musculo-skeletal disorders in industry: "an ergonomic approach". Bournemouth, England: Anglo-European College of Chiropractic, 1985.

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Karpati, George. Disorders of voluntary muscle. 8th ed. Cambridge: Cambridge University Press, 2010.

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Sayler, Mary Harwell. The encyclopedia of the muscle and skeletal systems and disorders. New York, NY: Facts On File, 2005.

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American Academy of Orthopaedic Surgeons, ed. Disorders of the proximal biceps tendon: Evaluation and treatment. Rosemont, IL: AAOS, American Academy of Orthopaedic Surgeons, 2014.

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David, Legge. Close to the bone: The treatment of musculo-skeletal disorder with acupuncture and other traditional Chinese medicine. 2nd ed. Woy Woy, N.S.W: Sydney College Press, 1997.

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Close to the bone: The treatment of musculo-skeletal disorder with acupuncture and other traditional Chinese medicine. Woy Woy, NSW, Australia: Sydney College Press, 1990.

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Karen, Bellenir, ed. Pain sourcebook: Basic consumer health information about specific forms of acute and chronic pain, including muscle and skeletal pain, nerve pain, cancer pain, and disorders characterized by pain, such as fibromyalgia ... 2nd ed. Detroit: Omnigraphics, 2002.

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Book chapters on the topic "Musculo skeletal disorders"

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Kherbache, Houda, Lahcene Bouabdellah, Mohamed Mokdad, Ali Hamaïdia, and Abdenacer Tezkratt. "Musculo Skeletal Disorders (MSDs) Among Algerian Nurses." In Advances in Intelligent Systems and Computing, 289–97. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-96098-2_38.

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Ekholm, J., and K. Schüldt Ekholm. "Vocational rehabilitation in musculo-skeletal disorders — with examples mainly from the neck and shoulder region." In Collection de L’Académie Européenne de Médecine de Réadaptation, 137–42. Paris: Springer Paris, 2006. http://dx.doi.org/10.1007/2-287-29745-6_9.

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Evans, William J. "Skeletal Muscle Effects on the Skeleton." In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 978–85. Ames, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118453926.ch117.

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Lynch, Gordon S., David G. Harrison, Hanjoong Jo, Charles Searles, Philippe Connes, Christopher E. Kline, C. Castagna, et al. "Skeletal Muscle Disorder." In Encyclopedia of Exercise Medicine in Health and Disease, 789. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_4520.

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Herrero-Hernandez, Pablo, Atze J. Bergsma, and W. W. M. Pim Pijnappel. "Generation of Human iPSC-Derived Myotubes to Investigate RNA-Based Therapies In Vitro." In Methods in Molecular Biology, 235–43. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_15.

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AbstractAlternative pre-mRNAsplicing can be cell-type specific and results in the generation of different protein isoforms from a single gene. Deregulation of canonical pre-mRNAsplicing by disease-associated variants can result in genetic disorders. Antisense oligonucleotides (AONs) offer an attractive solution to modulate endogenous gene expression through alteration of pre-mRNAsplicing events. Relevant in vitro models are crucial for appropriate evaluation of splicing modifying drugs. In this chapter, we describe how to investigate the splicing modulating activity of AONs in an in vitro skeletal muscle model, applied to Pompe disease. We also provide a detailed description of methods to visualize and analyze gene expression in differentiated skeletal muscle cells for the analysis of muscledifferentiation and splicing outcome. The methodology described here is relevant to develop treatment options using AONs for other genetic muscle diseases as well, including Duchenne muscular dystrophy, myotonic dystrophy, and facioscapulohumeral muscular dystrophy.
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Pette, D. "Skeletal Muscle Adaptation in Response to Chronic Stimulation." In Electrical Stimulation and Neuromuscular Disorders, 12–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71337-8_2.

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Saüc, Sophie, and Maud Frieden. "Neurological and Motor Disorders: TRPC in the Skeletal Muscle." In Store-Operated Ca²⁺ Entry (SOCE) Pathways, 557–75. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-57732-6_28.

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Pham, Mirko, Marcel Wolf, Philipp Bäumer, Martin Bendszus, and Gregor Kasprian. "MRI of Muscle Denervation in Central and Peripheral Nervous System Disorders." In Magnetic Resonance Imaging of the Skeletal Musculature, 221–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/174_2013_928.

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Lüttgau, Hans Christoph, and George Dimitrie Stephenson. "Ion Movements in Skeletal Muscle in Relation to the Activation of Contraction." In Physiology of Membrane Disorders, 449–68. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4613-2097-5_28.

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Barone, Rosario, Valentina Di Felice, Dario Coletti, and Alberto J. L. Macario. "Hsp60 in Skeletal Muscle: From Molecular Anatomy to Pathophysiology." In Heat Shock Protein 60 in Human Diseases and Disorders, 269–76. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23154-5_17.

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Conference papers on the topic "Musculo skeletal disorders"

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Wang, Ruizhe, Gerard Medioni, Carolee J. Winstein, and Cesar Blanco. "Home Monitoring Musculo-skeletal Disorders with a Single 3D Sensor." In 2013 IEEE Conference on Computer Vision and Pattern Recognition Workshops (CVPRW). IEEE, 2013. http://dx.doi.org/10.1109/cvprw.2013.83.

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Torsteinsen, Ronnaug, Arne Jarl Ringstad, Sten Glenn Haaberg, and Geir Olav Hjertaker. "A Risk Assessment Tool To Avoid Musculo-Skeletal Disorders Related To Manual Work." In SPE International Conference on Health, Safety and Environment in Oil and Gas Exploration and Production. Society of Petroleum Engineers, 2010. http://dx.doi.org/10.2118/126286-ms.

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Gangopadhyay, Somnath, Sayantika Das, Shreya Sinha, Santi Ranjan Dasgupta, and Subrata Goswami. "293 Investigation on the prevalence of musculo-skeletal disorders among jute mill workers in india." In 32nd Triennial Congress of the International Commission on Occupational Health (ICOH), Dublin, Ireland, 29th April to 4th May 2018. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/oemed-2018-icohabstracts.767.

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Papoutsakis, Konstantinos, Manolis Lourakis, and Maria Pateraki. "Automatic assessment of posture deviations in assembly tasks." In 13th International Conference on Applied Human Factors and Ergonomics (AHFE 2022). AHFE International, 2022. http://dx.doi.org/10.54941/ahfe1002145.

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The aim of this study is to investigate the development and the evaluation of a computer vision-based framework to aid the automatic assessment of posture deviations in assembly tasks in realistic work environments. A posture deviation refers to a time-varying working posture performed by the worker, that deviates from ergonomically safe body postures expected in the context of particular work tasks and is known to impose increased physical strain. The estimation of their occurrences can serve as indicators, known as risk factors, for the assessment of physical ergonomics towards the prevention of physical strain and in the-long-term of work-related musculo-skeletal disorders (WMSD). Using visual information acquired by camera sensors, our goal is to estimate the full body motion of a line worker in 3D space, unobtrusively, and to perform classification of four types of posture deviations, also noted as ergonomically sub-optimal working postures that were employed by the MURI risk analysis tool. We formulate a learning-based action classification task using Deep Graph-based Neural Networks and differential temporal alignment cost as a classification measure to estimate the type and risk level of the observed posture deviation during work activities. To evaluate the efficiency of the proposed approach, a new video dataset was captured in the context of the sustAGE project, that demonstrate two different workers during car door assembly actions in a simulated production line in an actual workplace. Rich annotation data were provided by experts in manufacturing and ergonomics. Both quantitative and qualitative evaluation of the proposed framework provide evidence for its efficiency and reliability in supporting ergonomic risk assessment and preventive actions for WMSD in real working environments.
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Seth, Deep, Damien Chablat, Fouad Bennis, Sophie Sakka, Marc Jubeau, and Antoine Nordez. "New dynamic muscle fatigue model to limit musculo-skeletal disorder." In VRIC '16: Virtual Reality International Conference - Laval Virtual 2016. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2927929.2927935.

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Luthfi, Muhammad, and Baiduri Widanarko. "Analysis of Individual, Physical, and Psychosocial Risk Factors on Work-Related Skeletal Muscle Disorders in Workers in Tourism Sector: A Systematic Review." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.01.28.

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ABSTRACT Background: Based on observations and interviews conducted with workers in the tourism sector, there were subjective complaints of work-related skeletal muscle disorders experienced by workers. But it was still an inadequate explanation of the cause of work-related skeletal muscle disorders in workers. This study aimed to investigate the analysis of individual, physical, and psychosocial risk factors on work-related skeletal muscle disorders in workers at the tourism sector. Subjects and Method: A systematic review was conducted by searching from PubMed, Science Direct, and Scopus databases. The inclusion criteria were the studies identifying the association of individual, physical, and psychosocial risk factors with work-related skeletal muscle disorders in workers of the tourism sector. The articles must be published full texts in English-language between 2005 and 2020. The quality, measure of association, and level of evidence of the selected studies were critically appraised. The data were reported according to PRISMA flow chart. Results: Twelve articles, consisting of ten cross-sectional, one exploratory, and one cohort study designs, were obtained. The study subjects worked at hotels and restaurants. Nine articles showed high quality, and the other three articles showed low-quality. These articles reported an association between risk factors and work-related skeletal muscle disorders. The individual, physical, and psychosocial risk factors included gender, BMI, repetitive motion, excessive reaching, and the number of room cleaning per day. Conclusion: Twelve articles with different quality show the association between risk factors and work-related skeletal muscle disorders. The risk factors include gender, BMI, repetitive motion, excessive reaching, and the number of room cleaning per day in workers of the tourism sector. Keywords: work-related skeletal muscle disorders, risk factors, ergonomy, tourism Correspondence: Muhammad Luthfi. Occupational Safety and Health Program, Faculty of Public Health, Universitas Indonesia. Email: Muhluthfi93@gmail.com. Mobile: 082220279794. DOI: https://doi.org/10.26911/the7thicph.01.28
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Umairah, Siti, Vanessa Adela Putri, Rosyida Rosyida, and Raihanatu Binqalbi Ruzain. "Effectiveness of Holistic Self Care to Overcome Work-Related Skeletal Muscle Disorder in Palm Workers Using Harvasting Tool Dodos: A Systematic Review." In The 7th International Conference on Public Health 2020. Masters Program in Public Health, Universitas Sebelas Maret, 2020. http://dx.doi.org/10.26911/the7thicph.02.39.

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Background: Oil palm Dodos workers manually harvest the palm fresh fruit which can cause work related musculoskeletal disorders (WMSDS). Holistic self-care by combining stretching exercises and breathing techniques is believed to be able to overcome work related skeletal muscle disorders. The study aimed to conduct a systematic review of research articles identifying the effectiveness of holistic self-care in overcoming work-related skeletal muscle disorders in Riau palm Dodos workers, and identifying the frequency of implementing holistic self-care. Subject and Method: A systematic review was conducted through electronic database, including Google scholar, Science Open, and ScienceDirect. The keywords used were “musculoskeletal disorders” AND “stretching exercise” AND “breathing technique”. The articles were collected between 2009 to 2020. Results: The article analysis used in this study were 4 articles. The effectiveness of holistic self-care (stretching exercise and breathing technique) showed 30 minutes of exercise per day for 5 days per week for a period of 6 weeks can overcome the skeletal muscle disorders caused by work related neck, shoulder, upper, and low back pain in workers. Conclusion: Holistic self-care (stretching exercise and breathing technique) overcomes work related musculoskeletal disorders in workers. Keywords: work related musculoskeletal disorders, holistic self-care. Correspondence: Siti Umairah. Psychology Study Program, Faculty of Psychology, University of Islamic Riau, Pekanbaru, Riau, Indonesia. Email: pujaumayrah@gmail.com. Mobile: +628 2250453378. DOI: https://doi.org/10.26911/the7thicph.02.39
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Fregly, Benjamin J., Yi-Chung Lin, Jonathan P. Walter, Marcus G. Pandy, Scott A. Banks, and Darryl D. D’Lima. "Muscle and Contact Contributions to Inverse Dynamic Knee Loads During Gait." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206558.

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Musculoskeletal computer models capable of predicting muscle and joint contact forces accurately during human movement could facilitate the design of improved joint replacements and new clinical treatments for articular cartilage defects or movement-related disorders [1]. A primary challenge to developing such predictions is the non-uniqueness of the calculated muscle forces, often referred to as the “muscle redundancy problem” [2]. Since more muscles act on the skeleton than the number of degrees of freedom in the skeleton, an infinite number of possible muscle force solutions exist.
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Couper, Nathan, Robert Day, Patrick Renahan, Patrick Streeter, and Elizabeth DeBartolo. "Air Muscle Powered Ankle Foot Orthotic." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14136.

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Foot drop, a disorder that affects millions of people worldwide, is a broad term used to describe a neurological or muscular-skeletal condition that restricts an individual’s ability to dorsiflex — raise — their foot about the ankle joint. Common causes of foot drop are stroke, ALS (Lou Gehrig’s disease), MS, and injury. Unassisted, an individual with foot drop will have difficulty walking as the affected foot easily catches on obstacles. Foot drop causes clients to drag their toes on each step, greatly increasing the risk of a trip or fall.
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Amini, Rouzbeh, Alina Oltean, Vincent Barnett, Yoav Segal, and Victor H. Barocas. "Mechanical Properties of the Porcine Lens Capsule." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192664.

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Basement membranes are ubiquitous. In humans, genetic disorders in basement membranes can lead to many complications including kidney disease, skeletal muscle myopathy, hearing loss, and ocular abnormalities[1]. We hypothesize that genetic mutation of the microstructure of the lens capsule basement membrane will alter its mechanical properties. Because of its unique thickness and anatomically distinct margins, the lens capsule is the only site in the body where large-scale mechanical tests on the basement membrane can be made.
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Reports on the topic "Musculo skeletal disorders"

1

Jalil, Yorschua, and Ruvistay Gutierrez. Myokines secretion and their role in critically ill patients. A scoping review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, September 2021. http://dx.doi.org/10.37766/inplasy2021.9.0048.

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Review question / Objective: 1-How and by which means stimulated muscle from critically ill patients can liberate myokines?, 2-Which are the main characteristics of the critically ill population studied and if some of these influenced myokine´s secretion?, 5-Can myokines exert local or distant effects in critically ill patients?, 5-Which are the potential effects of myokines in critically ill patients? Eligibility criteria: Participants and context: We will include primary studies (randomized or non-randomized trials, observational studies, case series or case report) that consider hospitalized critically ill adult patients (18 years or older) in risk for developing some degree of neuromuscular disorders such as ICU-AW, diaphragmatic dysfunction, or muscle weakness, therefore the specific setting will be critical care. Concept: This review will be focused on studies regarding the secretion or measure of myokines or similar (exerkines, cytokines or interleukin) by any mean of muscle activation or muscle contraction such as physical activity, exercise or NMES, among others. The latter strategies must be understood as any mean by which muscle, and there for myocytes, are stimulated as result of muscle contraction, regardless of the frequency, intensity, time of application and muscle to be stimulated (upper limb, lower limb, thoracic or abdominal muscles). We also will consider myokine´s effects, local or systemic, over different tissues in terms of their structure or function, such as myocytes function, skeletal muscle mass and strength, degree of muscle wasting or myopathies, among others.
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