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Schroll, Ilse. "Genexpression während der Zahnentwicklung der Maus (Mus musculus)." Diss., lmu, 2004. http://nbn-resolving.de/urn:nbn:de:bvb:19-18423.
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Schroll, Ilse. "Genexpression während der Zahnentwicklung der Maus (Mus musculus) Literaturstudie /." [S.l.] : [s.n.], 2004. http://edoc.ub.uni-muenchen.de/archive/00001842.
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Rinkwitz, Silke. "Molekulare Untersuchungen zur Innenohrmorphogenese bei der Maus (mus musculus)." [S.l. : s.n.], 1998. http://deposit.ddb.de/cgi-bin/dokserv?idn=955476097.
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Manolakou, Ekaterini. "Etude multilocus d'interactions génomiques entre les sous-espèces "Mus musculus musculus" et "Mus musculus domesticus" à partir des croisements contrôlés." Montpellier 2, 1996. http://www.theses.fr/1996MON20136.
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Ce travail porte sur les interactions genomiques entre deux sous-especes de souris, mus musculus musculus et m. M. Domesticus, qui forment une zone d'hybridation traversant l'europe, a partir de croisements controles. Les principaux resultats reveles par les analyses genetiques multilocus de retrocroisements intersubspecifiques sont: a) un certain nombre de biais de transmission, en ce qui concerne la segregation mono et multilocus b) des modifications locales importantes du taux de recombinaison, sur le chromosome x, entre marqueurs lies et c) certaines correlations entre la fertilite individuelle des femelles f1 et le pourcentage du genome maternel transmis. Pour expliquer l'ensemble de ces observations, une combinaison de deviations meiotiques chez les f1 (phenomenes d'affinite chromosomique et de distorsion de segregation) et de selection post-zygotique precoce chez les backcross, devrait operer. La complexite des interactions genomiques revelees suggere l'existence d'un grand nombre de genes epistatiques impliques dans la divergence fonctionnelle entre les deux taxons. La cohesion globale du genome, traduite par la distribution des classes d'heterozygotes des descendants backcross, pourrait au niveau de la zone d'hybridation renforcer la reduction du flux genique entre les deux sous-especes
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Derothe, Jean-Marc. "Parasitisme et évolution hôte : approche expérimentale de la susceptibilité des hybrides entre les souris "Mus musculus musculus" et "Mus musculus domesticus"." Montpellier 2, 1999. http://www.theses.fr/1999MON20120.
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Les deux sous-especes de souris mus musculus musculus et mus musculus domesticus se rencontrent le long d'une zone d'hybridation qui s'etend du danemark a la bulgarie. L'introgression limitee entre les deux genomes a conduit a considerer cette zone comme une zone de tension, c'est a dire que les hybrides seraient contre selectionnes par rapport aux individus parentaux. Le seul indicateur d'une telle contre-selection est une charge parasitaire en helminthes intestinaux superieure chez les individus hybrides. L'hypothese proposee pour expliquer ce phenomene est compatible avec la theorie des zones de tension, c'est a dire que cette susceptibilite hybride serait le resultat d'une rupture de coadaptation genomique au niveau du systeme immunitaire. Dans ce travail, nous nous sommes donc attaches a caracteriser l'origine et l'etendue de la susceptibilite hybride. D'une part, nous avons infeste, de maniere controlee, des hybrides experimentaux avec l'oxyure aspiculuris tetraptera afin de determiner si la recombinaison etait a l'origine de la susceptibilite hybride. D'autre part, nous avons infeste des souris parentales et introgressees avec deux autres parasites : le trypanosome trypanosoma musculi et la coccidie sarcocystis muris. Il ressort de ce travail que la susceptibilite hybride, bien qu'elle ne puisse etre generalisee a tous les parasites, ne concerne pas uniquement les helminthes intestinaux. De plus, ce phenomene ne semble pas etre la consequence directe d'une rupture de coadaptation, mais semble du a un effet de pleiotropie antagoniste particulier a la zone hybride. Ces resultats affinent notre perception de la zone d'hybridation entre les deux sous-especes de souris et du role que jouent les parasites dans son evolution.
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Ivantcheva, Aglika. "Le rôle des mécanismes comportementaux dans l'isolement reproductif et la spéciation des souris sauvages "Mus musculus musculus", "Mus macedonicus" et "Mus spicilegus"." Montpellier 2, 1997. http://www.theses.fr/1997MON20026.
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Nous avons analyse les mecanismes comportementaux qui maintiennent la divergence entre trois especes de souris sauvages. Les relations socio-sexuelles qui sont a la base de leur isolement reproductif sont variables. Les individus modifient leurs comportements en fonction de l'espece du protagoniste. Les particularites ethologiques observees sont expliquees a la lumiere de l'histoire de l'espece et de leurs zones de contact. La discrimination comportementale est la base de l'isolement reproductif. Chez les especes apparues recemment (us spicilegus et us ace onicus) la discrimination s'effectue sur un ensemble de traits presents chez les protagonistes, et pas seulement sur des stimulis heritables (odeurs). L'effet de l'impregnation joue un role principal sur la discrimination comportementale. Par ailleurs, nous avons analyse les interactions entre les mecanismes selectifs et les traits soumis a la selection qui auraient pu intervenir dans la speciation des especes. Nous constatons que les odeurs, considerees comme des traits apparents chez la souris, ne sont pas toujours la base des interactions sociales. D'autres stimulis, notamment moteurs (comportementaux) peuvent etre primordiaux pour l'etablissement des mecanismes comportementaux (preferences associatives). Nous proposons un scenario evolutif concernant la speciation des trois especes dans lequel les interactions entre les facteurs correles (mecanisme/trait de selection) constituent la base des evenements evolutifs
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Osterloh, Anke. "Hitzeschockprotein 60 (Hsp60) als immunologischer Signalverstärker in der Maus (Mus musculus)." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=976820706.
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Johnson, Maria Suzanne. "Limits to sustainable metabolic rate in Mus musculus." Thesis, University of Aberdeen, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265054.
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Limits to sustainable metabolic rate were sought in lactating MFI mice, Mus musculus. Lactating mice appeared to reach a limit in the food intake during later lactation (days 13 to 16) at 23 g/day, and also with litter sizes above 8 pups. This plateau resulted in pups from larger litters being lighter than pups from smaller litters. Maternal resting metabolic rate (RMR) increased two fold from prebreeding to peak lactation. Prebreeding RMR was not found to be correlated with either litter size or litter mass. RMR at peak lactation was positively correlated with litter size, but when the effect of body mass on both RMR and litter size was removed, the relationship was no longer significant. The major morphological component influencing RMR at peak lactation was the mass of the carcass and skeletal muscle. When females faced the demands of pregnancy and lactation concurrently, they ate significantly less food and yet raised heavier pups, than females just lactating. To avoid the peak demands of pregnancy and lactation overlapping, females delayed the implantation of the concurrent pregnancy by between 2 and 11 days. The extent of this delay was related to the size of the lactating litter. Lactating females exposed to the cold (8oC) for the second half of lactation increased their food intake by an average of 30%, however the pups were still lighter than those raised at 21oC, and fewer were weaned in the cold. Lactating females were unable to increase their milk energy output, with increasing litter size at 21oC. There was no difference in the gross energy content of the milk produced by females at 21oC or at 8oC. However, the females raising litters in the cold produced a greater volume of milk than those in the warm. The results obtained indicate that although females reach a plateau in their food intake and milk production with increasing litter size, this may not be due to a limit acting either on the alimentary tract or the mammary tissues, as females are able to increase both food intake and milk production when exposed to cold during lactation.
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Paya-Cano, Jose Luis. "Functional genomics and cognitive performance in Mus musculus." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417696.
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Lafkas, Ginamarie N. "MicroRNA targeting in mus musculus and Caenorhabditis elegans." Thesis, Massachusetts Institute of Technology, 2011. http://hdl.handle.net/1721.1/68432.
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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.Cataloged from PDF version of thesis.
Includes bibliographical references (p. 45-52).
MicroRNAs (miRNAs) are small, approximately 22 nucleotide RNAs that regulate gene expression post-transcriptionally by base-pairing to complementary sites in the target mRNA. The first miRNA, lin-4, was discovered in 1993 in Caenorhabditis elegans; since then hundreds of miRNAs have been identified in C. elegans, Drosophila melanogaster, plants, mouse, and humans, where they approach a number equivalent to 1-2% of the protein-coding genes. With the exception of plants, miRNAs most commonly regulate targets by imperfectly pairing to 3' untranslated regions (UTRs), leading to translational repression or mRNA destabilization. The microRNA miR-196 is encoded at three paralogous locations in the HoxA, B, and C clusters in mammals and has conserved complementarity to the 3'UTRs of Hoxb8, Hoxc8, and Hoxa7; in particular, miR-1 96 has complete complementarity to Hoxb8 with the exception of a single G:U wobble. In 2004, Yekta et al., were able to detect RNA fragments diagnostic of miR-1 96-directed cleavage of Hoxb8 transcript in mouse embryos, and cell culture experiments showed down-regulation of Hoxb8, Hoxc8, Hoxd8, and Hoxa7. To address the biological significance of miR-196 mediated repression of Hox genes in vivo, we attempted to generate targeted transgenic mice for the Hoxa7, b8 and c8 genes. These mice would allow us to study the resulting phenotypic and molecular consequences and determine the impact this regulation has on establishment of the anterior-posterior axis in the developing embryo as well as its role in defining the expression boundaries of the individual Hox genes in vivo. The lin-4 miRNA plays a role in regulating the heterochronic genes involved in larval development in C. elegans. We used luciferase assays to test the efficacy of the seven proposed lin-4 binding sites in the lin-14 3'UTR and to determine if lin-4 is capable of recognizing and mediating repression through them. The wild-type lin-14 3'UTR was compared with mutant UTRs in which the lin-4 target sites were mutated. We determined that the three canonical 8mer sites are functional, as expected, and that at least one of the four additional sites is also recognized by lin-4 and contributes to the overall repression of the lin-14 3'UTR.
by Ginamarie N. Lafkas.
S.M.
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Silva, Adriano Rios da. "Transmissão sexual do Trypanosoma cruzi em Mus musculus." reponame:Repositório Institucional da UnB, 2013. http://repositorio.unb.br/handle/10482/14829.
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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de
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A doença de Chagas é uma patologia que acomete milhares de pessoas no mundo inteiro, principalmente no continente Americano. O Trypanosoma cruzi, agente etiológico da doença de Chagas, é transmitido principalmente pelo inseto triatomíneo durante o repasto sanguíneo. Além da transmissão vetorial, a doença de Chagas pode ser adquirida por via transfusional, congenital ou pelo consumo de alimentos contaminados. A possibilidade da transmissão sexual da doença de Chagas foi sugerida por Carlos Chagas em 1909, entretanto, poucos trabalhos foram publicados sobre o tema desde então. O presente trabalho teve como objetivo investigar a transmissão sexual do Trypanossoma cruzi no modelo experimental murino. Para isso, foram feitos testes parasitológicos, sorológicos e moleculares em 20 camundongos infectados e em seus parceiros sexuais, inicialmente sadios. Os resultados mostraram que após o acasalamento com animais infectados, os parceiros sexuais apresentaram testes sorológicos positivos em 60% dos casos, enquanto que o DNA nuclear do parasito foi identificado no sangue dos animais analisados. Além disso, duas fêmeas inicialmente sadias apresentaram testes de hemocultura positivos após acasalarem com machos infectados, confirmando assim a trasmissão sexual do T. cruzi. Os resultados dos testes sorológicos e moleculares dos filhotes mostraram uma discrepância entre a sorologia e os resultados de PCR, sendo que o teste molecular apresentou uma maior sensibilidade. A taxa de infecção congênita obtida pelos métodos sorológicos revelaram que 14% dos filhotes provenientes dos Grupos A e B adquiriram a infecção, enquanto que o teste de PCR demonstrou uma positividade de 58%. A análise histopatológica não foi capaz de mostrar a presença de ninhos de amastigotas no coração dos animais infectados, tanto pela via intraperitonial, como pela via sexual. No entanto, pôde-se observar a presença de extenso infiltrado inflamatório destruindo as fibras cardíacas em todos os animais infectados. A análise de imunohistoquímica realizada em cortes histológicos de testículos de camundongos infectados revelou uma grande quantidade de formas amastigotas no túbulo seminífero e epidídimo. A capacidade de infecção do sêmem proveniente de indivíduo infectado pelo T. cruzi foi verificada. As análises histopatológicas mostraram a presença de ninhos de amastigotas no coração de fêmeas infectadas a partir da inoculação intra-vaginal de sêmen humano. Dessa forma, nossos resultados mostram que ocorreu transmissão sexual do Trypanosoma cruzi em camundongos.
Chagas disease is a condition that affects thousands of people worldwide, mainly in the Americas. Trypanosoma cruzi, etiologic agent of Chagas disease, is transmitted primarily by triatomine insect during blood feeding. Besides vetorial transmission, Chagas disease can be acquired by blood transfusion, congenital or by consumption of contaminated food. The possibility of sexual transmission of Chagas disease has been suggested by Carlos Chagas in 1909, however, few studies have been published on the subject since then. The present study aimed investigate sexual transmission of Trypanosoma cruzi in experimental murine model. For this, parasitological, serological and molecular infected mice and their sexual partners, initially healthy. The results showed that after mating with animals infected sexual partners serological tests showed positive in 60% of cases, while the nuclear DNA of the parasite was identified in blood from all animals analyzed. In addition, two healthy females initially showed positive blood culture tests after mating with infected males, thus confirming the sexually transmitted T. cruzi. The results of serological and molecular tests of pups showed a discrepancy between serology and PCR results, and the molecular test showed a higher sensitivity. Congenital infection rate obtained by serological methods showed that 14% of the from Groups A and B acquired infection, whereas the PCR test showed an 58% positivity. Histopathological analysis was not able to show the presence of nests of amastigotes in the hearts of infected animals, either by intraperitoneal as through sex. However, it was observed the presence of extensive inflammatory infiltrate destroying cardiac fibers in all infected animals. Immunohistochemical analysis performed in histological testis infected mice revealed a large amount of amastigotes in seminiferous tubule and epididymis. The ability of infection semen from individual infected with T. cruzi was verified. The histopathological analysis showed the presence of nests of amastigotes in the heart of infected females from intravaginal inoculation of human semen. Thus, our results show that there was sexual transmission of Trypanosoma cruzi in mice.
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Barbosa, Luiz Gustavo Bicas. "Avaliação dos valores bromatológicos de camundongos (Mus musculus)." Botucatu, 2020. http://hdl.handle.net/11449/192879.
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Orientador: Carlos Roberto TeixeiraResumo: Os camundongos (Mus musculus) atualmente compõem a base alimentar de diversas espécies animais, tanto mamíferos como aves e répteis. tendo assim certa importância para o manejo nutricional de animais de vida livre que necessitam de tratamento, por acidentes, tráfico, animais cativos em zoológicos e centros e triagens, e animais que são comercializados como pets exóticos. Este trabalho teve por objetivo fornecer uma base de informações de dieta em relação às necessidades nutricionais de animais que se alimentam de camundongos. Foi comparado o conteúdo nutricional de quatro grupos (G1, G2, G3, G4) de camundongos diferenciados por origem e tempo de congelamento. Cada grupo gerou um pool do qual mediu-se a composição centesimal (umidade, lipídios, proteínas, cinzas), calorimetria, os minerais: Sódio (Na), Potássio (K), Cálcio (Ca), Magnésio (Mg), Fósforo (P), Ferro (Fe), Manganês (Mn), Cobre (Cu), Selênio (Se), e Zinco (Zn) e feito o perfil de ácidos graxos. Observou-se diferença estatística quando a umidade e proteínas, e quanto a amostra in natura sem congelamento quando comparada com as amostras in natura congeladas. Os resultados apresentaram uma variação (p<0,001) entre os animais provindo de biotérios e de fonte comercial, mostrando divergência no padrão de qualidade, determinando pouca confiança dos valores nutricionais de animais adquiridos congelados de fonte comercial.
Abstract: Mice (Mus musculus) currently make up a food base for several animal species, both mammals, birds and reptiles. having the same importance for the nutritional management of free-living animals that can be treated, by accidents, trafficking, captive animals in zoos and centers and screens, and animals that are marketed as exotic pets. This work aimed to provide a base of information on diet in relation to the nutritional needs of animals that feed on mice. It was compared or nutritional content of four groups (G1, G2, G3, G4) of mice differentiated by origin and freezing time. Each group generated a pool of which type of chemical composition (composition, lipids, proteins, ash), calorimetry and minerals: Sodium (Na), Potassium (K), Calcium (Ca), Magnesium (Mg), Phosphorus (P), Iron (Fe), Manganese (Mn), Copper (Cu), Selenium (Se), and Zinc (Zn) and fat profile or profile. Observe the statistical difference when a molecule and proteins and how much a fresh sample are compared to frozen samples. The results showed a variation (p <0.001) between animals that come from biotechnology and commercial sources, showing divergence in the quality standard, determining little confidence in the nutritional values of animals purchased frozen from commercial sources.
Mestre
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Solé, i. Canal Mireia. "Posicionament cromosòmic en cèl·lules de l’espermatogènesi de Mus musculus." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/666890.
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Els cromosomes ocupen regions específiques del nucli anomenades territoris cromosòmics. En cèl·lules somàtiques, el posicionament dels cromosomes està condicionat per la densitat gènica, l’activitat transcripcional i el contingut de guanina-citosina. Aquestes associacions evidencien l’existència d’una relació funcional entre la territorialitat cromosòmica i l’expressió gènica. Disposem de poques dades sobre el posicionament cromosòmic durant l’espermatogènesi. Alguns autors suggereixen que la distribució dels cromosomes en cèl·lules espermatogèniques podria condicionar el correcte desenvolupament de l’espermatogènesi i tenir implicacions en l’expressió gènica de l’embrió.
L’objectiu d’aquesta tesi doctoral va ser establir un model tridimensional de la territorialitat cromosòmica durant les diferents fases del procés de l’espermatogènesi de Mus musculus. Per assolir aquest objectiu es va desenvolupar una metodologia per a l’estudi tridimensional del posicionament cromosòmic en cèl·lules germinals i espermatozoides amb la finalitat de descriure el posicionament i identificar els factors que regulen la territorialitat dels cromosomes en aquests tipus cel·lulars.
Es va utilitzar teixit testicular procedent d’individus de la soca C57BL/6J de Mus musculus. La metodologia desenvolupada va consistir en l’aplicació dels següents procediments: i) fixació cel·lular preservant la tridimensionalitat nuclear, ii) hibridació in situ fluorescent de tots els cromosomes de ratolí, iii) captura d’imatges amb microscòpia confocal, iii) identificació cel·lular mitjançant immunofluorescència, iv) anàlisi d’imatges utilitzant el programa Matlab, v) obtenció de dades numèriques i anàlisi estadística. Aquesta metodologia va permetre l’estudi del posicionament de tots els cromosomes del genoma de ratolí en cinc estadis cel·lulars que cobreixen la totalitat del procés espermatogènic: espermatogoni-preleptotè inicial, espermatòcits I a l’estadi de preleptotè mitjà-zigotè, espermatòcits I a l’estadi de paquitè, espermàtides rodones i espermatozoides. Per cada estadi es van obtenir dades del volum de cada cromosoma, la posició dels cromosomes en relació a l’eix centre-perifèria nuclear i les freqüències d’encavalcament entre cromosomes.
Els resultats van posar de manifest que el posicionament radial i relatiu dels cromosomes durant l’espermatogènesi és dinàmic i no aleatori. Són nombroses les evidències observades que permeten concloure que els esdeveniments cromosòmics que condueixen a la recombinació meiòtica determinen la dinàmica de posicionament dels cromosomes homòlegs des de l’etapa d’espermatogoni fins a l’etapa de paquitè. En aquest sentit s’ha observat que els cromosomes homòlegs comparteixen el mateix territori cromosòmic en etapes properes a l’inici de la meiosi. A més, l’estructura de bouquet condiciona l’organització territorial del nucli a l’etapa de paquitè en funció de la mida cromosòmica, observant-se els cromosomes més petits preferentment a la part perifèrica del nucli. D’altra banda, l’anàlisi dels resultats indica que l’activitat gènica és un paràmetre que condiciona el posicionament radial dels cromosomes durant tot el procés de l’espermatogènesi. La part interna del nucli presenta una concentració de material genètic superior al valor esperat. A més, els cromosomes amb més quantitat de gens implicats en el procés de l’espermatogènesi o espermiogènesi (en el cas de les espermàtides rodones), mostren més volum cromosòmic a la zona mitja-interna del nucli. Finalment, hem observat que els cromosomes sexuals presenten un posicionament radial dinàmic durant l’espermatogènesi, directament relacionat amb els processos d’inactivació transcripcional que experimenten al llarg del procés. En relació al posicionament relatiu entre cromosomes, els resultats van mostrar que les interaccions entre cromosomes al nucli de les cèl·lules germinals i dels espermatozoides no són aleatòries suggerint implicacions funcionals rellevants. Tot i així, no s’han identificat els factors que determinen aquesta posició relativa a excepció de l’efecte de la mida en l’estadi de paquitè i en les espermàtides rodones. Finalment, també s’ha pogut concloure que el posicionament dels cromosomes respecte l’eix longitudinal del nucli dels espermatozoides no és aleatori suggerint la importància d’un posicionament longitudinal ordenat pels processos d’alliberament i activació del genoma patern desprès de la fecundació.Chromosomes occupy specific regions of the nucleus called chromosome territories. In somatic cells, the positioning of the chromosomes is conditioned by gene density, transcriptional activity and the guanine-cytosine content. These associations demonstrate the existence of a functional relationship between chromosomal territoriality and gene expression. Little is known about chromosomal positioning during spermatogenesis. Some authors have suggested that the chromosomes distribution in spermatogenic cells could affect spermatogenesis development and have implications for embryo gene expression. The objective of this doctoral thesis was to establish a three-dimensional model of chromosomal territoriality during the different stages of the Mus musculus spermatogenesis. To achieve this objective, we have developed a methodology for performing three-dimensional study of chromosomes positioning in germ cells and spermatozoa with the aim to describe the chromosome positioning, and to identify the factors that regulate the territoriality of the chromosomes in these cell types. Testicular tissue from individuals of C57BL6J Mus musculus strain was used. The methodology developed consisted in the following procedures: i) optimized cell fixation to preserve the three-dimensionality of the nuclei, ii) fluorescence in situ hybridization of all mouse chromosomes, iii) three-dimensional image captures by confocal microscopy, iii) cell identification by immunofluorescence iv) image analysis using Matlab, v) numerical data extraction and statistical analysis. This methodology allowed the study of all chromosomes positioning of the mouse genome in five cellular stages, which cover the whole spermatogenic process: spermatogonia-early preleptotene, spermatocytes I at mid preleptotene-zygotene stages, spermatocytes I at pachytene stage, round spermatids and spermatozoa. For each stage, data of the nuclear volume occupied by each chromosome were obtained, the position of chromosomes according to the central-peripheral nuclear axis and the overlapping frequency between chromosomes. Results showed that radial and relative positioning of chromosomes during spermatogenesis is dynamic and non-random. Several evidences were observed indicating that the chromosomal events that lead to meiotic recombination determine the dynamics of homologue chromosomes position from spermatogonia to pachytene stage. In this sense, it has been observed that homologous chromosomes share the same chromosomal territory in stages near the beginning of meiosis. In addition, the bouquet distribution affects the territoriality organization of the nucleus at pachytene stage in accordance to chromosomal size, being the smallest chromosomes preferably observed in the nucleus periphery. On the other hand, several pieces of data suggest that gene activity is closely associated with the radial positioning of chromosomes throughout the spermatogenesis process. For instance, the nucleus interior presents a higher concentration of genetic material than the expected value. In addition, chromosomes with more number of genes involved spermatogenesis process or spermiogenesis (in the case of round spermatids), show more chromosomal volume in the middle-internal area of the nucleus. Finally, we have observed that sex chromosomes present a dynamic radial positioning during spermatogenesis, directly related to the transcriptional inactivation processes that they experience throughout the process. In relation to the relative positioning between chromosomes, the results showed that the interactions between chromosomes in the nucleus of germ cells and spermatozoa are not random, suggesting relevant functional implications. Even so, it has not been identified any factors that determine the relative position to the exception of the effect chromosome size at pachytene stage and round spermatids. Finally, it has also been concluded that the chromosome positioning in relation to the longitudinal axis of the sperm nucleus is not random, suggesting the importance of an ordered longitudinal positioning for the processes of release and activation of the paternal genome after fertilization.
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Jabs, Normund. "Expressionsanalyse des Transkriptionsfaktors Nkx6.1 in Mus musculus (Linneaus, 1758)." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=975901818.
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Masterson, Dawn E. "Infanticide and parental care in mice Mus musculus domesticus." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241418.
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Smith, Frances Victoria. "Behaviour and immune function in laboratory mice : (Mus musculus)." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338530.
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Christophe-Ligonnière, Nathalie. "Echanges possibles entre les deux sous-especes de souris, mus musculus musculus et mus musculus domesticus et leurs hybrides : etude du role des comportements sociaux et des preferences sexuelles." Paris 13, 1999. http://www.theses.fr/1999PA132023.
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Les deux sous-especes de souris, mus musculus musculus et mus musculus domesticus, presentent une zone d'hybridation naturelle qui s'etend du danemark a la mer noire. Une introgression differentielle des alleles est observee, qui s'etend davantage dans les populations de m. M. Musculus. Cette etude se propose d'analyser, chez des souches du danemark, les relations entre partenaires au sein de chacune de ces sous-especes puis, entre elles deux et enfin, leurs interactions avec leurs hybrides. Des experiences de choix d'odeurs montrent qu'il existe une preference pour un partenaire du sexe oppose homosous-specifique chez m. M. Musculus, et non chez m. M. Domesticus. Ces derniers montrent meme un certain interet pour les odeurs heterosous-specifiques. La majorite des hybrides preferent egalement l'odeur musculus, a l'exception d'une categorie de males. Des adoptions semblent montrer le role de l'experience precoce dans le developpement de ces preferences. Les rencontres entre individus domesticus de meme sexe sont plus tolerantes que chez musculus. De plus, en rencontres intersous-specifiques, les individus domesticus, males et femelles, sont dominants par rapport aux musculus. Les rencontres male-femelle chez chaque sous-espece sont plutot tolerantes. Mais les males changent de comportement face a une femelle de l'autre sous-espece, en particulier les males musculus semblent eviter les femelles domesticus. La reproduction chez les couples intrasous-specifiques, intersous-specifiques et back-cross montrent des variations en terme de nombre de jeunes par portee, latence de premiere portee ou encore proportion de couples avec et sans descendance. Cette approche experimentale, du role de quelques mecanismes comportementaux dans les processus evolutifs, montre que ces caracteristiques comportementales, couplees aux performances reproductrices des couples, pourraient contribuer a expliquer, en partie, les differences d'introgression observees entre les deux sous-especes.
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Porcherie, Adeline. "Susceptibilité aux parasites des hybrides entre "Mus musculus" et "Mus musculus domesticus" : origine du phénomène et rôle dans la contre-sélection des hybrides." Montpellier 2, 2005. http://www.theses.fr/2005MON20083.
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Kasper-Sonnenberg, Monika. "Identifizierung und Charakterisierung von Interaktionen synaptischer Proteine aus Mus musculus." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=983013926.
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Kaltwasser, Sebastian. "Volumetric Manganese Enhanced Magnetic Resonance Imaging in mice (mus musculus)." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-141742.
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Oliva, Jean L. (Jean Louise). "The Teratogenic Effects of Nocodazole and Acrylamide in Mus Musculus." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc500254/.
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In two separate experiments, weight adjusted doses of nocodazole and acrylamide were injected intraperitoneally at various time intervals into twelve week old female mice. Within the nocodazole experiment, the doses were injected at varying time intervals before and after mating. On day seventeen of gestation, the female mice were sacrificed and their uterine contents examined. Nocodazole induced a significant increase in reproductive pathology per total implants when administered one hour after mating to the (SECxC57BL)F, stock: 5.00% total deads, 70.23% moles, and 3.41% abnormal fetuses. Acrylamide treatment produced a significant reduction in live births when administered six hours after mating: 50.86% moles and 46.46% living fetuses per total implants.
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Brown, Kara Mutso Amelia Tuttle Alexander H. "Sex dependent affiliation behavior and empathic approach in Mus musculus." Diss., Connect to the thesis, 2008. http://hdl.handle.net/10066/1430.
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Harper, Antonia C. "Behavioural and physiological effects of neonatal handling of Mus musculus." Thesis, Keele University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401046.
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Wang, Kenan. "Behavioural and neurohumoral mechanisms of environmental analgesia in Mus musculus." Thesis, University of Bradford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305727.
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Römer, Dirk. "Untersuchungen zur künstlichen Beatmung bei der Maus (Mus musculus) mit dem UNO Micro-Ventilator®." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-17777.
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Skinner, N. C. "Aspects of circadian rhythms in feral house mice, Mus musculus L." Thesis, University of Westminster, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373438.
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Rankin, Judith. "Some effects of prenatal exposure to aluminium in mice (Mus musculus)." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/14251.
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The influence of prenatal exposure to aluminium sulphate (Al2(SO4)3) on the behavioural development of mice (Mus musculus) from two inbred strains was examined. Pregnant CBA/T6 and C57BL/6J mice were exposed by intraperitoneal (i.p.) injection (200mg/kg) or orally (750, 1000 and 1250mg/L) to Al2(SO4)3. On postnatal day one, pups were cross-fostered and tested in a variety of ethological measures, from birth to adulthood, to assess effects on the mother and the behavioural development of the pups. As a neurochemical marker for the cholinergic system, choline acetyltransferase (ChAT) activity was measured at different developmental stages. Breeding performance, the length of gestation and sex ratio were unaffected by Al exposure administered via the i.p. route. There was a transient reduction in maternal weight gain during gestation. CBA pups born to Al-treated mothers exhibited lower body weights at birth; this reduction persisted into adulthood only in treated pups reared by treated mothers and was more pronounced in the case of female mice. The body weight changes were accompanied by delays in the maturation of several of the tests of sensory-motor development. Al-treated CBA females were hypoactive at weaning compared to controls, whilst the converse was true for males. 77% control and 55% treated males reached criterion in a maze test and controls required fewer days to do so. The effect of Al exposure on the cholinergic system was dependent on the region of the brain studied, and still showed significant effects in the adult. In utero exposure to injected Al resulted in a reduction in the rate of ultrasonic calling by CBA pups and was accompanied by a delay in the timing of peak calling. C57 pups were not affected to the same degree. Exposure to oral Al caused a similar but less obvious trend towards a diminished calling. The inclusion of the recording of ultrasonic calling is recommended in any test battery aimed at assessing behavioural teratogenicity.
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GONÇALVES, Daniel José Dias. "Efeito da minociclina em Mus Musculus infectados com Trypanosoma brucei brucei." Master's thesis, Instituto de Higiene e Medicina Tropical, 2011. http://hdl.handle.net/10362/11418.
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As patologias provocadas tanto em humanos como em outros mamíferos, pelo parasita hemoflagelado Trypanosoma brucei são um verdadeiro flagelo em África, ma-tando milhares de pessoas e cabeças de gado todos os anos. No caso da terapêutica hu-mana, todas as drogas foram implementadas em meados do século XX, sem novas pa-tentes desde 1981. Urge portanto a descoberta de novas moléculas, que em esquema monoterapêutico ou em associação, possam de alguma forma intervir no controlo do parasita ou contra a inflamação provocada pelas sucessivas ondas de parasitémia.
Em estudos anteriores a minociclina, tetraciclina de 2ª geração, provou ser eficaz na protecção do sistema nervoso central (SNC) de ratos infectados com Trypanosoma brucei brucei (T.b.brucei), diminuindo a passagem pela barreira hemato-encefálica (BHE) de leucócitos e parasitas. No presente estudo, o efeito dessa droga parece estar relacionado com uma maior resistência à perda de vários componentes hematológicos como eritrócitos, leucócitos ou granulócitos em amostras de animais com vinte dias (20 DPI) de progressão de infecção com o parasita. Também as parasitémias são substanci-almente mais baixas (cerca de dez vezes menores) nos animais tratados em 20 DPI. Em termos das citocinas interleucina 4 (IL-4), interferão gama (IFN-γ) e óxido nítrico (NO), parece existir um padrão de secreção diferente nos animais tratados e não tratados. A IL-4 parece neste caso estar associada a um perfil anti-inflamatório; o NO, importante no controlo do parasita, existe em maiores quantidades nos animais tratados, ao contrá-rio do IFN-γ com quantidades mais elevadas nos animais controlos. Esta última citocina está escrita na literatura como factor de crescimento parasitário.
A expressão de metaloproteinases é aparentemente superior no baço quando comparada com tecido hepático, contudo sem aparentes diferenças entre os dois grupos persisitindo um sistema de dupla banda compreendidas entre r de 30 e 40 kDa, valores
de massa molecular, na maioria dos animais dos dois grupos. As metaloproteinases po-dem se endógenas do hospedeiro, mas com elevada possibilidade de serem secretadas pelo parasita no seu processo de invasão tecidular.The pathologies of humans and other mammals caused by the haemoflagelate parasite Trypanosoma brucei are a true burden in Africa, killing thousands of people and cattle every year. In the case of human therapeutics, every drug was implemented in the mid-twentieth century, with no new patents being registered since 1981. It is urgent, therefore, to discover new molecules which in a monotherapeutical scheme or in associ-ation with other drugs can somehow intervene in the control of the parasite or the in-flammation caused by successive waves of parasitaemia. In previous studies, minocycline, which is a second generation tetracycline, has proven effective in the protection of the central nervous system (CNS) of infected mice, impeding the passage of the blood-brain barrier (BBB) for both leukocytes and para-sites. In the present study, the effect of this drug seems to correlate with a greater re-sistance to the loss of several haematological components like erythrocytes, leukocytes or granulocytes in samples from animals with 20 days of progression of T. brucei infec-tion. Also, the parasitaemias seem to be substantially lower (10 fold) in treated animals for the same time of infection and for the cytokine pattern, interleukine 4 (IL-4), inter-feron gamma (IFN-γ) and nitric oxid (NO), for which there seems to be a different se-cretion pattern when comparing treated and untreated animals. IL-4, which has a dubi-ous role in the infection by trypanosomes, seems to be related with an anti-inflammatory profile, and NO, essential to control the parasite, exists in greater quanti-ties in treated animals, unlike IFN-γ which displays higher levels in control animals. The latter is described in the literature as a parasite growth factor. The proteinase expression is greater in the spleen, however there are no obvious differences between the two groups, while there is a persistence of a system of two pro-teinases with molecular masses comprised between 30 and 40 kDa in almost all of the samples, which can be endogenous. Yet, there is a strong possibility that this metallo-proteinases can be secreted also by parasites, helping their tissue invasion.
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Smithson, Jacqueline Louise. "The effects of corticosterone on persistence of attention in Mus Musculus." Thesis, Keele University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716859.
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Amaral, Marta Gonçalves. "Transferência gênica em células espermáticas de Mus musculus e Ramdia quelen." Universidade Federal de Pelotas, 2009. http://guaiaca.ufpel.edu.br/handle/123456789/1270.
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Previous issue date: 2009-12-28Transgenic animals have been used as biological models in studies of the genes functions and their mechanisms of action, as well as to improve animal production. Researchers are trying to produce transgenic animals that will be organs donors in xenotransplants. Another use of the transgenic animal is in the production of recombinant proteins for pharmaceutical interest, starting from several tissues and corporal fluids of different animal species. Using TMGT (Testis Mediated Gene Transfer), the efficiency of pEGFP transgene transmission in mice using non surgical TMGT was evaluated, without epididymis electroporation; using transfectants as DMSO, liposomes, and for the first time the DMA. To evaluate the efficiency of non surgical TMGT in F0 the EGFP expression was evaluated in vivo and detection in genome was conducted by PCR analysis. Moreover, we evaluated which transfectants were more efficient in transgene transmission and if it induce histological damage in testis, by histological analysis. EGFP expression was not detected in F0 through the ultraviolet light.The result of the PCR analysis shows that liposomes and DMSO were the best transfectants for pEGFP in F0. The histological analysis shows that injections of DMSO with exogenous DNA could affect the development of the germ cell of seminal tubules. The purpose about SMGT was to evaluate the interaction of the spermatozoa of silver catfish with pEGFP vector. It was observed that the semen after three washes in isosmotic solution and at 1000 x g centrifugation could eliminate seminal plasma proteins and preserve cellular motility. The time of action of DNase in the seminal plasma was 30 minutes, the temperature of action of DNase ranged between 33-53°C and its inhibition was detected at 70°C. In the presence of EDTA 30mM the activity of DNase was inhibited. Through PCR it was detected that in the DNA of the silver catfish s spermatozoids, the amplicon of EGFP at different concentrations of pEGFP vector (5-100 ng/106 spermatozoa). We demonstrate that spermatozoa of the silver catfish need to be washed to remove seminal plasma before contact with exogenous DNA, after several washes exogenous DNA was internalized in spermatozoa.
Os animais transgênicos vêm sendo empregados como modelos biológicos em estudos das funções dos genes e dos seus mecanismos de ação, bem como para melhorar a produção animal. Pesquisadores vêm tentando produzir animais transgênicos que serão doadores de órgãos em xenotransplantes. Outra utilização da transgênese animal é a produção de proteínas recombinantes de interesse farmacêutico a partir de diversos tecidos e fluidos corporais de diferentes espécies de animais. Em relação à TMGT (Testis Mediated Gene Transfer) foi avaliada a eficiência da transmissão do transgene EGFP em camundongos, utilizando a TMGT não cirúrgica, sem o uso de eletroporação no epidídimo; utilizando transfectantes como o DMSO, lipossomos, e pela primeira vez o DMA. A detecção da expressão do EGFP foi avaliada in vivo na F0 e por PCR, para comprovar a eficiência da TMGT não cirúrgica. Também foi analisado qual dos transfectantes propiciou a maior taxa de transmissão e se eles causaram danos histológicos aos testículos, através de análise histológica. Não foi detectada a expressão de EGFP, através da luz ultravioeta na F0. Os resultados da análise de PCR demonstraram que o lipossomo e o DMSO foram os melhores transfectantes do pEGFP na F0. A análise histológica demonstrou que a injeção de DMSO com o DNA exógeno, pode comprometer o desenvolvimento das células germinativas do túbulo seminal. O objetivo em relação à SMGT (Sperm-mediated gene transfer) foi avaliar a interação dos espermatozóides de silver catfish (Rhandia quelen) com o vetor pEGFP. Foi observado que o sêmen após três lavagens em solução isosmótica e centrifugadas à 1000 x g, eliminaram as proteínas do plasma seminal e preservaram a motilidade celular. O tempo de atividade da DNase no plasma seminal foi de 30 minutos, a temperatura de atividade da DNase variou entre 33-53°C e sua inativação ocorreu aos 70°C. Na presença de EDTA 30mM a atividade da DNase foi inibida. Através da PCR foi detectada a presença do pEGFP no DNA dos espermatozoides do silver catfish, que incorporaram o vetor em diferentes concentrações (5-100 ng/106 espermatozoides). Concluímos que os espermatozoides do silver catfish precisam ser lavados para retirada do da DNase do plasma seminal antes de entrar em contato com o DNA exógeno, e que após as lavagens ocorreu a internalização do DNA exógeno no espermatozoide.
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Nettles, Rachel Marie. "Bacterial Community Ecology of the Colon in Mus musculus." BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6912.
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The gut microbiome is a community of closely interacting microbes living in the gastrointestinal tract. Its structure has direct relevance to health. Disturbances to the microbiome, such as due to antibiotic use, have been implicated in various diseases. The goal of this study was to determine how the gut microbiome reacts to and recovers from disturbance caused by antibiotics. Because diet also influences the microbiome, this study included the interaction between diet and antibiotics. Half of the mice in each diet treatment were given antibiotics to disturb their microbiomes. After cessation of antibiotics, mice were paired in combinations within diets to determine whether the microbiomes of control mice influenced the disturbed microbiomes of formerly antibiotic mice. Chapter 1. Diet significantly altered the structure of the gut microbiome but its effect was significantly smaller than the effect of antibiotics. There was a significant interaction between diet and antibiotics; the antibiotic effect was larger in the cornstarch diet than in the glucose diet. Dysbiotic microbiomes resulting from antibiotics were characterized by an increase in Bacteroidetes and Proteobacteria, and a decrease in Firmicutes. Antibiotic administration also resulted in an initial increase OTU diversity, mainly because it reduced the abundance of dominant OTUs, resulting in greater evenness. Chapter 2. Seven weeks after the cessation of antibiotics (experiment termination), the effect of the antibiotics on the microbiome was still evident. The structure of the dysbiotic microbiome had not returned to that of control mice. Antibiotics significantly increased the relative abundance of some taxa and significant decreased the relative abundance of others. It was unexpected that the taxonomic hierarchy within the microbiome did not recover after 7 weeks following cessation of antibiotics. It would appear, therefore, that antibiotics established a new, semi-stable hierarchy. Chapter 3. When paired together, the assumption was that dysbiotic microbiomes of antibiotic mice would be positively influenced by microbiomes of control mice, based on the assumption that the control mouse would act as a probiotic for the antibiotic mouse, either via coprophagy or consumption of food contaminated by feces. Contrary to that hypothesis, the microbiomes of control mice became more similar to that of antibiotic mice. One can offer at least two hypotheses to explain this result, but neither was tested. First, compared to the control microbiome, the dysbiotic microbiome may have been more stable and thus more resistant to change due to invasion by OTUs from the control microbiome. Other research has shown that dysbiotic microbiomes have a high degree of stability. If this were true, the use of probiotics is questionable. Second, one or more of the antibiotics could still have been active at the initial phase of pairing, and coprophagy caused the microbiome of the control mice to rapidly become dysbiotic. If this is true, the experiment should have been conducted with a waiting period between the cessation of antibiotic administration and pairing.
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Vanlerberghe, Flavie. "Histoire évolutive de la zone d'hybridation naturelle entre les deux sous-espèces de souris européennes Mus musculus domesticus et Mus musculus musculus : dynamique de l'introgression de gènes autosomaux, de l'ADN mitochondrial et du chromosome Y." Montpellier 2, 1988. http://www.theses.fr/1988MON20001.
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Discrimination des genomes des sous especes m. M. Domesticus et m. M. Musculus etudie a l'aide de differents marqueurs genetiques, locus autosomaux, chromosome y et adn mitochondiral; mise en evidence d'une zone d'hybridations entre ces especes
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Vanlerberghe, Flavie. "Histoire évolutive de la zone d'hybridation naturelle entre les deux sous-espèces de souris européennes Mus musculus domesticus et Mus musculus musculus dynamique de l'introgression de gènes autosomaux, de l'ADN mitochondrial et du chromosome Y /." Grenoble 2 : ANRT, 1988. http://catalogue.bnf.fr/ark:/12148/cb37618998j.
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Monteros, Juan Carlos. "Conservação evolutiva da proteína STI1 nas espécies Mus musculus e Danio rerio." reponame:Repositório Institucional da UFPR, 2009. http://hdl.handle.net/1884/20677.
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Berting, Jennifer Irene. "Inbreeding effects on physiological responses to chronic hypoxia in mice (Mus musculus) /." Electronic version (PDF), 2007. http://dl.uncw.edu/etd/2007-3/bertingj/jenniferberting.pdf.
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Cromie, Anthea Alexandra. "Behavioural and physiological counter-strategies to infanticide in mice (Mus musculus domesticus)." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241423.
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Costello, Aron K. "Female Characteristics that Influence Male Mate Preference in House Mice (Mus Musculus)." Miami University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=miami1280754434.
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Cottignoli, Stefano <1979>. "Expression and cellular localization of Copper transporter 2 (Ctr2) in Mus musculus." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1883/1/Cottignoli_Stefano_tesi.pdf.
Full textAbstract:
The Ctr family is an essential part of the copper homeostasis machinery and its members share sequence homology and structural and functional features.
Higher eukaryotes express two members of this family Ctr1 and Ctr2.
Numerous structural and functional studies are available for Ctr1, the only high affinity Cu(I) transporter thus far identified. Ctr1 holigotrimers mediate cellular copper uptake and this protein was demonstrated to be essential for embryonic development and to play a crucial role in dietary copper acquisition.
Instead very little is known about Ctr2, it bears structural homology to the yeast vacuolar copper transporter, which mediates mobilization of vacuolar copper stores. Recent studies using over-expressed epitope-tagged forms of human Ctr2 suggested a function as a low affinity copper transporter that can mediate either copper uptake from the extracellular environment or mobilization of lysosomal copper stores.
Using an antibody that recognizes endogenous mouse Ctr2, we studied the expression and localization of endogenous mouse Ctr2 in cell culture and in mouse models to understand its regulation and function in copper homeostasis.
By immunoblot we observed a regulation of mCtr2 protein levels in a copper and Ctr1 dependent way. Our observations in cells and transgenic mice suggest that lack of Ctr1 induces a strong downregulation of Ctr2 probably by a post-translational mechanism.
By indirect immunofluorescence we observed an exclusive intracellular localization in a perinuclear compartment and no co-localization with lysosomal markers.
Immunofluorescence experiments in Ctr1 null cells, supported by sequence analysis, suggest that lysosomes may play a role in mCtr2 biology not as resident compartment, but as a degradation site.
In appendix a LC-mass method for analysis of algal biotoxins belonging to the family of PsP (paralytic shellfish poisoning) is described.
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Cottignoli, Stefano <1979>. "Expression and cellular localization of Copper transporter 2 (Ctr2) in Mus musculus." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1883/.
Full textAbstract:
The Ctr family is an essential part of the copper homeostasis machinery and its members share sequence homology and structural and functional features.
Higher eukaryotes express two members of this family Ctr1 and Ctr2.
Numerous structural and functional studies are available for Ctr1, the only high affinity Cu(I) transporter thus far identified. Ctr1 holigotrimers mediate cellular copper uptake and this protein was demonstrated to be essential for embryonic development and to play a crucial role in dietary copper acquisition.
Instead very little is known about Ctr2, it bears structural homology to the yeast vacuolar copper transporter, which mediates mobilization of vacuolar copper stores. Recent studies using over-expressed epitope-tagged forms of human Ctr2 suggested a function as a low affinity copper transporter that can mediate either copper uptake from the extracellular environment or mobilization of lysosomal copper stores.
Using an antibody that recognizes endogenous mouse Ctr2, we studied the expression and localization of endogenous mouse Ctr2 in cell culture and in mouse models to understand its regulation and function in copper homeostasis.
By immunoblot we observed a regulation of mCtr2 protein levels in a copper and Ctr1 dependent way. Our observations in cells and transgenic mice suggest that lack of Ctr1 induces a strong downregulation of Ctr2 probably by a post-translational mechanism.
By indirect immunofluorescence we observed an exclusive intracellular localization in a perinuclear compartment and no co-localization with lysosomal markers.
Immunofluorescence experiments in Ctr1 null cells, supported by sequence analysis, suggest that lysosomes may play a role in mCtr2 biology not as resident compartment, but as a degradation site.
In appendix a LC-mass method for analysis of algal biotoxins belonging to the family of PsP (paralytic shellfish poisoning) is described.
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Brockschnieder, Damian. "Herstellung und Charakterisierung eines binär-genetischen Systems zur Zellablation in der Maus (Mus musculus) mittels Diphtherie-Toxin." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969477996.
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Resühr, David. "Der Einfluss von kalorischer Restriktion und Melatonin auf die circadiane Physiologie der Maus (Mus Musculus, Linnaeus 1758)." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973278099.
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Neussert, Rudgar [Verfasser]. "Pathomechanismen der Best'schen Makuladystrophie in der Maus (Mus musculus Linnaeus 1758, Muroidea): Funktion des Bestrophins / Rudgar Neussert." München : Verlag Dr. Hut, 2010. http://d-nb.info/1009095285/34.
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Beiersdorfer, Antonia Benita Verfasser], and Christian [Akademischer Betreuer] [Lohr. "Charakterisierung panglialer Kommunikationsmechanismen im Bulbus olfactorius der Maus (Mus musculus L.) / Antonia Benita Beiersdorfer ; Betreuer: Christian Lohr." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:18-103491.
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Beiersdorfer, Antonia Benita [Verfasser], and Christian [Akademischer Betreuer] Lohr. "Charakterisierung panglialer Kommunikationsmechanismen im Bulbus olfactorius der Maus (Mus musculus L.) / Antonia Benita Beiersdorfer ; Betreuer: Christian Lohr." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/1208003038/34.
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Roberts, David G. "The behavioural endocrinology of infanticide and parental care in mice (Mus musculus domesticus)." Thesis, Queen's University Belfast, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241500.
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Barnett, L. K. "The genetic heterogeneity of hair proteins from inbred strains of mouse, Mus musculus." Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355498.
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Chabokdast, Anna. "Multibody dynamics modelling of the masticatory system of the house mouse (Mus musculus)." Thesis, University of Hull, 2015. http://hydra.hull.ac.uk/resources/hull:10929.
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Understanding the function of masticatory system of the mouse, the model of choice for craniofacial studies is invaluable, yet has been investigated poorly. Multibody dynamic analysis (MDA), which is a 3D computer modelling technique used in this study, is ideally suited to replicate and investigate this complex system. To mechanically solve this intricate system, system indeterminacy should be tackled using optimisation algorithms. The mouse has two types of teeth, hence two very different types of biting: incisal and the molar biting. To understand the masticatory function, modelling these two types of biting is invaluable. This study aims to investigate the differences in muscle function between incisors and molar biting. It was hypothesized that the generated bite force in the first molar would be higher than the incisor, due to the mechanical advantage of the latter. Moreover, the model sensitivity to the optimisation algorithms and the constraint types as well as muscle attributes such as intrinsic stress value and cross sectional area were studied. Functional development of the masticatory system of the mouse was an additional interest in this study. The first MDA model of the adult mouse masticatory system was developed and two optimisation algorithms, Dynamic geometric optimisation (DGO) and minimisation of overall muscle energy (MOME), were used to overcome the system indeterminacy. Furthermore, individual-specific adult model were developed and maximal and sub-maximal incisor and first molar biting were simulated. In addition, a simplistic model of the juvenile incisal biting was developed in which maximal incisal bite force and muscle activation pattern was studied. Some divergences were predicted from DGO and MOME, which were resulted from different basis of the activation factors in the two algorithms. Nevertheless, DGO was chosen as the optimisation algorithm mainly because it allowed for the simulation of a full biting cycle and for inclusion of some key developments in the future. The maximum predicted bite force in incisal biting was lower than the in vivo measurement, which was possibly due to averaging PCSA across specimens. A correction factor of 25% was added to muscle intrinsic stress value to compensate for this underestimation. Moreover as expected, the maximum predicted bite force at the first molar position was larger than that of the incisor. It was also found that the ratio of muscle forces between incisal and molar biting did not remain constant, however, was more consistent for simulation of low bite forces. In addition, incisal bite force in juvenile model was in agreement with in vivo bite force measurement from the same individual. MDA presented here provides a model which may be used to study many functional tasks and to investigate functional development and intertwined relationship between function and development in the mouse and similar rodents.
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Belkhir, Khalid. "Différenciation chromosomique et évolution chez "Mus musculus domesticus" : cas des souris robertsoniennes d'Alsace." Montpellier 2, 1991. http://www.theses.fr/1991MON20161.
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L'etude chromosomique de souris domestiques (mus musculus domesticus) de la region d'alsace a ete realisee, permettant de mettre en evidence l'existence d'une population robertsonienne a fort polymorphisme chromosomique. D'autre part, l'etude de la structure de ces populations a nombre de chromosomes reduit a ete abordee par l'analyse de variants geniques par electrophorese enzymatique. A partir de ces donnees nous avons essaye, de facon analytique et a l'aide de simulations sur ordinateur, de tester la validite certaines hypotheses pour expliquer la fixation de remaniements sous-dominants dans le cas des souris. Une importance particuliere a ete donnee au facteur temps de fixation necessaire au deroulement de ce processus. De facon experimentale, nous avons teste l'existence d'une distorsion meiotique en faveur des chromosomes metacentriques, en croisant des souris alsaciennes ayant fixe deux fusions et segregeant pour une troisieme: aucune transmission preferentielle du chromosome fusionne n'est venue confirmer l'hypothese d'une action importante de la distortion meiotique dans la fixation successive des fusions rb. A partir de ces resultats, nous discutons des modeles de speciation chromosomique, et notamment du modele stasipatrique de white
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Seth, Pawan. "STUDY OF THE RELATIONSHIP BETWEEN Mus musculus PROTEIN SEQUENCES AND THEIR BIOLOGICAL FUNCTIONS." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1176736255.
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Forestier, Tatiana. "Environnement socio-olfactif et choix alimentaires chez la souris domestique, Mus musculus domesticus." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCD003/document.
Full textAbstract:
Le succès écologique de la souris domestique, Mus musculus domesticus, repose en partie par sa capacité à adapter son régime alimentaire aux ressources disponibles. La transmission sociale des préférences alimentaires (TSPA) est un apprentissage observé chez les rongeurs, leur permettant d’élargir leur répertoire alimentaire à moindre risque en obtenant des informations olfactives surde nouveaux aliments à partir des congénères. Cet apprentissage social s’observe directement,lors d’une rencontre avec un congénère ou indirectement, via des marques odorantes. Ce travail a pour but de déterminer comment les souris utilisent leur environnement socio-olfactif pour réaliser des choix alimentaires. Nos résultats ont révélé que l’absence du congénère lors de laTSPA indirecte réduit les contraintes sociales associées à une rencontre et permet l’acquisition de la TSPA entre femelles inconnues. Cependant, certaines contraintes physiques associées à la perception des informations dans les fèces peuvent réduire la disponibilité des informations alimentaires. Enfin, nous avons montré que les différentes préoccupations sexuelles des individus affectent la hiérarchisation des informations présentes dans les fèces et limitent, chez les mâles,l’acquisition de la TSPA. Nos résultats suggèrent que l’utilisation d’informations alimentaires chez les souris varie selon leur contexte social et écologique et implique différents processus tels que l’émotion et l’attention. En conditions naturelles, les voies directe et indirecte de la TSPA pourraient être complémentaires, chacune élargissant les conditions de transmission de l’information alimentaire chez les rongeursThe ecological success of the house mouse, Mus musculus domesticus, implies a great capacity to adapt its diet to available food resources. The social transmission of food preference (STFP) is an adaptive type of learning observed in rodents allowing them to enlarge their food repertoire at lower risk by getting olfactory information on novel food sources from conspecifics. This social learning takes place directly, during an encounter with a conspecific or indirectly, via olfactory marks. The objective of this thesis work was to determine how mice use their socio-olfactory environment to make food choices. Our results revealed that the absence of the conspecific during the indirect STFP reduces the social constraints associated with an encounter and allows the acquisition of STFP between unfamiliar conspecifics. However, some physical constraints associated with the perception of information in feces may reduce the availability of food information. We also showed that different sex concerns of individuals may affect the prioritization of information present in feces and limit, in males, the acquisition of STFP. Our results suggest that the use of food information in mice varies according to their social and ecological context and involves different processes such as emotion and attention. Under natural conditions, the direct and indirect STFP could be complementary, each of them extending the conditions for the transmission of food information in rodents