Academic literature on the topic 'Murine model'

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Journal articles on the topic "Murine model"

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Libby, Peter. "Murine “Model” Monotheism." Circulation Research 117, no. 11 (November 6, 2015): 921–25. http://dx.doi.org/10.1161/circresaha.115.307523.

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Rodenberger, Sharon L., Philip W. Ledger, and Mary E. Prevo. "Murine Model for Contact Sensitization." Toxicology Methods 3, no. 3 (January 1993): 157–68. http://dx.doi.org/10.3109/15376519309044573.

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&NA;. "Alzheimer??s: murine model made." Inpharma Weekly &NA;, no. 975 (February 1995): 7. http://dx.doi.org/10.2165/00128413-199509750-00015.

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González, G. M., R. Tijerina, L. Najvar, M. Rinaldi, I. T. Yeh, and J. R. Graybill. "Experimental murine model of disseminatedPseudallescheriainfection." Medical Mycology 40, no. 3 (January 2002): 243–48. http://dx.doi.org/10.1080/mmy.40.3.243.248.

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Hofflin, J. M., F. K. Conley, and J. S. Remington. "Murine Model of Intracerebral Toxoplasmosis." Journal of Infectious Diseases 155, no. 3 (March 1, 1987): 550–57. http://dx.doi.org/10.1093/infdis/155.3.550.

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Chang, Christopher H., Peggy A. Cotter, and Jeff F. Miller. "Murine model of Campylobacter infection." Gastroenterology 118, no. 4 (April 2000): A322—A323. http://dx.doi.org/10.1016/s0016-5085(00)83382-x.

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Gronski, T., E. Lum, J. Campbell, and S. D. Shapiro. "A Murine Model of Volutrauma." Chest 116 (July 1999): 28S. http://dx.doi.org/10.1378/chest.116.suppl_1.28s.

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Ahmed, Abdalla O., Wim Vianen, Marian T. Kate, Wendy W. J. Sande, Alex Belkum, Ahmed H. Fahal, Henri A. Verbrugh, and Irma A. J. M. Bakker-Woudenberg. "A murine model ofMadurella mycetomatiseumycetoma." FEMS Immunology & Medical Microbiology 37, no. 1 (June 2003): 29–36. http://dx.doi.org/10.1016/s0928-8244(03)00096-8.

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LINDSAY, R., and W. BOLGER. "Murine Model of Chronic Rhinosinusitis." Otolaryngology - Head and Neck Surgery 133, no. 2 (August 2005): P103—P104. http://dx.doi.org/10.1016/j.otohns.2005.05.220.

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Gupta, Umesh Datta, Ali Abbas, Raj Pal Singh Kashyap, and Pushpa Gupta. "Murine model of TB meningitis." International Journal of Mycobacteriology 5 (December 2016): S178. http://dx.doi.org/10.1016/j.ijmyco.2016.10.029.

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Dissertations / Theses on the topic "Murine model"

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Babaie, Yasmin. "A murine model for haemangioblast transplantation." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/23691.

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A promoter trap strategy was used to target a single allele of the flk-1 gene with one of two reporter constructs. One placed the EGFP reporter under flk-1 transcriptional control, while the other transcribed the selectable HPRT enzyme, which could be used to isolate flk-1 expressing cells in the HM1 hprt deficient ES cell line. Homologous recombination was successfully achieved with both targeting vectors. HPRT targeted selectable lines were successfully isolated. All lines showed appropriate transgene expression at high enough levels for effective HAT selection to isolate pure populations of flk-1 expressing cells. Two methods of deriving haemangioblastic progenitors from ES cells were tested for their efficacy of the isolation of a pure haemangioblast population based on the expression of flk-1. Methylcellulose cultures were found to be highly variable and problematic to carry out successfully whereas monolayer differentiation on collagen IV was more consistent. This system was then used to optimise the differentiation and selection regime applied to the flk-1/HPRT targeted cells in an attempt to isolate a pure haemangioblast progenitor population. Flk-1/HPRT targeted cells were marked with a constitutive GFP transgene, differentiated and selected for flk-1/HPRT expression on collagen IV. The selected cells were injected into the blastocyst stage embryo to see whether a developmentally more advanced cell population would survive and contribute to the expected cell lineages. Contribution of the GFP marked cells was observed in mesodermal and highly vascularised organs such as the heart, liver and kidney but was absent from the ectodermally derived brain. Expression was strongly localised around regions of vacularisation.
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Watkins, Alan D. "A murine model of pulmonary inflammation." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395963.

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Zychlinska, Magdalena. "Murine Model System for EBV-related Diseases." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-73499.

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Barnard, Amanda Louise. "A murine model for immunotherapy of melanoma." Thesis, King's College London (University of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298460.

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Levison, Scott. "Characterization of a murine model of colitis." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/characterization-of-a-murine-model-of-colitis(4b966667-a763-4bcc-8896-7a157cf3d3dd).html.

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Inflammatory bowel disease (IBD) represents a complex spectrum of gastrointestinal diseases. Incorporating Crohn's disease (CD) and ulcerative colitis (UC), IBD is characterised by recurrent and chronic inflammation, significant morbidity, and an increasing global prevalence. Scientific advances regarding the aetiology, pathogenesis and treatment of these relapsing immune-mediated diseases have developed in parallel to the study of experimental models of intestinal inflammation. The correlation of phenotype, histology and immune response with mucosal gene expression, permits the investigation of induced pathology for human translation. Trichuris muris (mouse whipworm) infection induces chronic colitis in susceptible strains (e.g. AKR). Chronic disease displays both a polarised CD4+ T-helper1 (TH1) immune response and histological, transmural colonic inflammation. Conversely, resistant mouse strains (e.g. BALB/c) exhibit transient infection and inflammation which quickly resolves under a presiding TH2 response. Work presented in this thesis investigates differential gene expression and biological pathways central to colonic outcome, and the genetic basis of chronic T. muris-induced colitis. This thesis demonstrates that the phenotypic and transcriptional profile of the T. muris model shared many similarities to widely used experimental models of colonic inflammation and to human IBD. Mice susceptible to chronic colonic inflammation displayed functional gene expression differences to those of resistant mice, including the up-regulation of pro-inflammatory, apoptosis and chemokine signalling pathway genes. Cellular homeostasis pathways and tight junction molecules were conversely down-regulated. Infected AKR demonstrated predominant TH1/ TH17 transcriptional activity, presenting this model as a platform to examine biological commonalities among chronic colitides. A Quantitative Trait Locus (QTL) study, performed by crossbreeding resistant and susceptible strains to T. muris infection, then identified key autosomal loci linked to chronic disease. Genes associated with known biological pathways, differential gene expression, and parental strain single nucleotide polymorphisms provided a novel and powerful strategy to reduce the number of candidate genes for further analysis. Of 7 T. muris (TM) QTL identified, 3 displayed overlap with other murine studies of parasite susceptibility. A separate locus, TM3, demonstrated overlap with published QTL in 3 unrelated experimental models of colitis and overlaid the Cdcs1 locus. TM3 possessed 33 significantly transcribed polymorphic genes (e.g. Ptpn22, Fcgr1, Rorc, Vcam1 and Vav3). Phenotypic pathway analysis, text mining and time-course qPCR all highlighted Vav3 (Human 1p13.3, murine Chr3 101.9 MB) as a key biological candidate in colitis susceptibility. As a final test of relevance to human disease, clinically proven IBD medications were administered to AKR mice post-T. muris infection, at a time-point when chronic disease was well established. Anti-TNFα Ab and corticosteroid therapy were shown to suppress TH1-driven experimental colitis, without affecting parasitic infection. Additionally, anti-TNFα Ab treatment was found to reduce pro-inflammatory macrophages yet preserve regulatory alternatively activated macrophage numbers within the colon. A previously unreported finding. Sharing biological commonalities with human CD, Trichuris muris colitis represents an advanced and tractable murine model for understanding the pathobiological mechanisms of chronic inflammatory disease. The key facet of this model is that despite identical injury some inbred mouse strains develop chronic colitis whilst others recover quickly and fully. The identification of differential mechanisms which govern outcome and a new platform to investigate novel targets of disease and disease therapy has implications for gastrointestinal inflammatory diseases and mucosal immunology.
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Healy, D. M. "Comparative pathology of Lyssaviruses in a murine model." Thesis, Queen's University Belfast, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.546358.

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Beer, Abigail J. "Development of an Inducible c-MYC Murine Model." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1602754882137456.

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Gibbons, Peter Luke. "Development of a Pharmacodynamic Model of Murine Malaria." Thesis, Curtin University, 2015. http://hdl.handle.net/20.500.11937/1031.

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The rational design of antimalarial therapies has historically been compromised by a paucity of pharmacodynamic data contributing to resistance through deployment of suboptimal doses. This thesis demonstrates a modified P. berghei murine malaria model for collecting detailed in vivo pharmacodynamic data and novel in silico mathematical model enabling optimisation of dosing and combination therapy. These models contribute to preclinical knowledge and provide the potential to assist in the development of methods to optimise clinical treatment.
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Luzzi, Keith J. "Quantification of metastatic inefficiency in a murine liver model." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/mq21109.pdf.

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Holland, T. W. C. "The pathogenesis of a murine model of rheumatoid arthritis." Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330136.

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Books on the topic "Murine model"

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Gisby, Angela Suzanne (nee Beale). Studies on Chlamydia trachomatis infection in an experimental murine model. Birmingham: University of Birmingham, 1996.

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Abecassis, Michael. The effect of prostaglandins on a murine model of fulminant viral hepatitis. Ottawa: National Library of Canada, 1990.

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Orrell, Julian Maxwell. Genetic influences on the granulatomous inflammatory response in a murine model of tuberculosis. Manchester: University of Manchester, 1994.

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Walker, Mark David. Promotion of accelerated repair in a radiation impaired wound healing model in murine skin. [s.l: The Author], 1999.

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Price, Jessica Caughman. Notch3 Signaling Promotes Adhesion and Tumor Progression in a Murine Epithelial Ovarian Cancer Model. [New York, N.Y.?]: [publisher not identified], 2017.

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Hodgson, Christopher Martin. Production of Interferon-gamma in a murine model of the induction phase of chemical allergy. [s.l.]: typescript, 1997.

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Joshi, Mital. Development and characterization of a graded, in vivo, compressive, murine model of spinal cord injury. Ottawa: National Library of Canada, 2000.

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Jones, Christopher David. The development of a murine model for analyzing the Th-cell response to a bovine rotavirus. [s.l.]: typescript, 1993.

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Abdel-Gawad, Yehia Mohamed. Nuclear protein changes in a murine model of myocarditis: The down regulation of histone H1ps, a differentiation - dependent protein. Ottawa: National Library of Canada, 1993.

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Galligan, Ethel. An investigation of the radioprotective effect of dietary antioxidants on normal tissue and tumour radiosensitivity: In vitro and in an in vivo murine model. [s.l: The Author], 1997.

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Book chapters on the topic "Murine model"

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Nishisaka, Nobuyasu, Philo Morse, Richard F. Jones, Ching Y. Wang, and Gabriel P. Haas. "Murine Animal Model." In Renal Cancer, 255–64. Totowa, NJ: Humana Press, 2001. http://dx.doi.org/10.1385/1-59259-144-2:255.

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Feng, Ningguo, Manuel A. Franco, and Harry B. Greenberg. "Murine Model of Rotavirus Infection." In Advances in Experimental Medicine and Biology, 233–40. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1828-4_35.

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Krishnamurthy, Prasanna, Suresh Kumar Verma, and Raj Kishore. "Murine Bone Marrow Transplantation Model." In Manual of Research Techniques in Cardiovascular Medicine, 146–48. Oxford, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118495148.ch17.

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Medina, Eva. "Murine Model of Pneumococcal Pneumonia." In Methods in Molecular Biology, 405–10. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1007/978-1-60761-058-8_22.

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Lugade, Amit A., Paul N. Bogner, and Yasmin Thanavala. "Murine Model of Chronic Respiratory Inflammation." In Crossroads between Innate and Adaptive Immunity III, 125–41. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-5632-3_11.

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Little, J. R., S. H. Stein, and K. D. Little. "Amphotericin B — A Model Murine Immunostimulant." In Antibiosis and Host Immunity, 253–63. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1901-6_29.

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Quan, D., Z. Zhang, A. Jevnikar, R. Zhong, and D. Grant. "Intestinal Transplantation in the Murine Model." In Organtransplantation in Rats and Mice, 649–52. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-72140-3_66.

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Badi, Niharika, and Zobeida Cruz-Monserrate. "Murine Model of Obesity-Induced Cancer." In Methods in Molecular Biology, 195–201. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2014-4_14.

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Guertin, Pierre A. "No-Laminectomy Spinal Cord-Transected Murine Model." In Animal Models of Spinal Cord Repair, 131–48. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-197-4_6.

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Wong, Paul K. Y., William S. Lynn, Y. C. Lin, Wonkyu Choe, and P. H. Yuen. "ts1 MoMuLV: A Murine Model of Neuroimmunodegeneration." In Neuroimmunodegeneration, 75–93. Berlin, Heidelberg: Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-662-12579-3_4.

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Conference papers on the topic "Murine model"

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Moffat, E. H., R. H. Furlong, A. L. Bloom, and J. C. Giddings. "A MURINE MODEL FOR FACTOR VIII ANTIBODY ANTI-IDIOTYPE REAGENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644030.

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The regulation of factor VIII antibody (FVIIIAb) production in haemophilic and non-haemophilic patients may be effected by anti-idiotype (Aid) antibodies which specifically react with FVIIIAb. Aid antibodies (reagents) were prepared from rabbits immunised with murine monoclonal FVIIIAb. Immuno fluorescent microscopy and cell culture studies were performed using murine hybridoma cells which secreted the FVIIIAbs.Immuno fluorescence studies examined the ability of the Aid reagents to bind to acetone fixed FVIIIAb secreting hybridoma cells. Positive surface membrane and intra-cytoplasmic staining patterns were seen with the Aid reagent when incubated with the corresponding murine hybridoma cell line. This reaction was blocked subsequent to the addition of the corresponding monoclonal FVIIIAb but was preserved when unrelated monoclonal FVIIIAb was incubated with the hybridoma cells. No fluorescence was observed when Aid reagent was incubated with unrelated FVIIIAb secreting hybridoma cultures.Following the addition of Aid reagent to FVIIIAb secreting hybridoma cultures and incubation for 19 hours, the resultant hybridoma supernatants were examined for FVIIIAb content using an immunoradiometric technique. The Aid reagent failed to inhibit FVIIIAb secretion by hybridoma cells. Thus, although Aid reagents were capable of binding to fixed FVIIIAb secreting cells, they failed to inhibit FVIIIAb secretion from hybridoma cultures. The conjugation of Aid reagent with immunotoxin may however have cytotoxic potential. The murine model provides a method for the study of Aid regulation of FVIIIAb production in haemophilia.
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Ballesteros-Zebadúa, P., J. M. Lárraga-Gutierrez, O. A. García-Garduño, M. C. Rubio-Osornio, V. Custodio-Ramírez, S. Moreno-Jimenez, J. E. Suarez-Campos, et al. "Irradiation Design for an Experimental Murine Model." In ELEVENTH MEXICAN SYMPOSIUM ON MEDICAL PHYSICS. AIP, 2010. http://dx.doi.org/10.1063/1.3531598.

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Kohn, A., M. Herriges, P. Basak, M. Ma, J. Le Suer, B. R. Thapa, D. N. Kotton, and F. J. Hawkins. "Preclinical Murine Model for Airway Cell Transplantation." In American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2547.

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Batista, Michael, Hadi T. Nia, Karen Cox, Christine Ortiz, Alan J. Grodzinsky, Dick Heinegård, and Lin Han. "Effects of Chondroadherin on Cartilage Nanostructure and Biomechanics via Murine Model." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14516.

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While small leucine rich proteins/proteoglycans (SLRPs) are present in very low concentrations in the extracellular matrix (ECM), they have been shown to be critical determinants of the proper ECM assembly and function in connective tissues [1] including bone [2], cornea [3], and cartilage [4]. However, their direct and indirect roles in matrix biomechanics and the potential for osteoarthritis-related dysfunction of cartilage remain unclear. With the advent of new high resolution nanotechnological tools, the direct quantification of cartilage biomechanical properties using murine models can provide important insights into how secondary ECM molecules, such as SLRPs, affect the function and pathology of cartilage [5]. Previous nanoindentation studies of murine cartilage have assessed the effects of maturation and osteoarthritis-like degradation of cartilage on its biomechanical properties [6, 7]. Recently, murine models have received increased attention because of the availability of specific gene-knockout and gene alteration technologies [8]. For example, chondroadherin (CHAD) is a non-collagenous small leucine-rich proteoglycan (SLRP) with α-helix and β-sheet secondary structure, spatially localized in the territorial matrix (MW = 38 kDa) [9]. In articular cartilage, CHAD is distributed non-uniformly with depth [10], and binds to type II collagen and the α2β1 integrin and is hypothesized to function in the communication between chondrocytes and their surrounding matrix, as well as in the regulation of collagen fibril assembly [11, 12] (Fig. 1). The objective of the present study is to explore the role of CHAD and its depletion on the structure and nanomechanical properties of both superficial and middle/deep zone cartilage. The current methods thereby enabled depth-dependent analysis of cartilage nanostructure and dynamic energy-dissipative mechanisms.
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Riscili, BP, T. Karsies, S. McMaken, D. Dakhlallah, N. Ali, M. Hunter, and CB Marsh. "Micro-RNA Expression in a Murine Model of Sepsis." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1165.

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Van Rheen, ZJ, SM Majka, J. West, and E. Nozik-Grayck. "Novel Murine Model To Study Pulmonary Hypertension: Bleomycin + Hypoxia." In American Thoracic Society 2009 International Conference, May 15-20, 2009 • San Diego, California. American Thoracic Society, 2009. http://dx.doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a1797.

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Yang, Dong, Ruola Ning, David Conover, Betancourt Ricardo, and Shaohua Liu. "Cone beam CT tumor vasculature dynamic study (Murine model)." In Medical Imaging, edited by Xiaoping P. Hu and Anne V. Clough. SPIE, 2008. http://dx.doi.org/10.1117/12.770762.

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Patel, Ankit, Brian Belt, Nathania Figueroa, Sapna Patel, Aditi Murthy, Kelli Connolly, Scott Gerber, and David Linehan. "Abstract A133: Micrometastatic progression of pancreas cancer: Murine model." In Abstracts: Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; September 25-28, 2016; New York, NY. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/2326-6066.imm2016-a133.

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Nakano, Hiroshi, Sumito Inoue, Hiroyoshi Machida, Kento Sato, Masamichi Sato, Yoshikane Tokairin, Akira Igarashi, Masafumi Watanabe, and Yoko Shibata. "Hyperhomocysteinemia promotes pulmonary emphysema in murine model of COPD." In ERS International Congress 2019 abstracts. European Respiratory Society, 2019. http://dx.doi.org/10.1183/13993003.congress-2019.pa2448.

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Kishta, Osama, Nurlan Dauletbaev, and Larry C. Lands. "Protein Oxidation In Pseudomonas Aeruginosa Murine Lung infection Model." In American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans. American Thoracic Society, 2010. http://dx.doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a1791.

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Reports on the topic "Murine model"

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Cook, Alonzo D. Realistic Murine Model for Streptozotocin-induced Diabetic Peripheral Neuropathy. Science Repository OÜ, August 2018. http://dx.doi.org/10.31487/j.rgm.2018.02.006.

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Richfield, Eric. A Murine Model of Genetic and Environmental Neurotoxicant Action. Fort Belvoir, VA: Defense Technical Information Center, September 1999. http://dx.doi.org/10.21236/ada374832.

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Richfield, Eric K. A Murine Model of Genetic and Environmental Neurotoxicant Action. Fort Belvoir, VA: Defense Technical Information Center, September 2001. http://dx.doi.org/10.21236/ada415995.

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Richfield, Eric K. A Murine Model of Genetic and Environmental Neurotoxicant Action. Fort Belvoir, VA: Defense Technical Information Center, September 2002. http://dx.doi.org/10.21236/ada416202.

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Shannon, Kevin M. Therapeutic and Biologic Studies in a Murine Model of NF1. Fort Belvoir, VA: Defense Technical Information Center, October 2001. http://dx.doi.org/10.21236/ada400468.

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Shannon, Kevin. Therapeutic and Biologic Studies in a Murine Model of NF1. Fort Belvoir, VA: Defense Technical Information Center, October 1999. http://dx.doi.org/10.21236/ada391081.

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Shannon, Kevin. Therapeutic and Biologic Studies in a Murine Model of NF1. Fort Belvoir, VA: Defense Technical Information Center, October 2000. http://dx.doi.org/10.21236/ada392385.

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O'Donnell, Christopher P. Sleep Resilience, Comorbid Anxiety, and Treatment in a Murine Model of PTSD. Fort Belvoir, VA: Defense Technical Information Center, April 2014. http://dx.doi.org/10.21236/ada603152.

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Shlomchik, Warren D. Mechanisms of Graft-vs.-Leukemia Against a Novel Murine Model of Chronic Myelogenous Leukemia. Fort Belvoir, VA: Defense Technical Information Center, July 2005. http://dx.doi.org/10.21236/ada443726.

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Jiao, Jing. Molecular Mechanism of Nkx3.1 Deregulation and Its Function in Murine Pten Prostate Cancer Model. Fort Belvoir, VA: Defense Technical Information Center, September 2005. http://dx.doi.org/10.21236/ada446368.

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