Journal articles on the topic 'Multivalent therapeutics'
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Farhadi, Shaheen A., and Gregory A. Hudalla. "Engineering galectin–glycan interactions for immunotherapy and immunomodulation." Experimental Biology and Medicine 241, no. 10 (May 2016): 1074–83. http://dx.doi.org/10.1177/1535370216650055.
Full textLee, JuYeon, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, et al. "Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1." Proceedings of the National Academy of Sciences 116, no. 18 (April 11, 2019): 8709–14. http://dx.doi.org/10.1073/pnas.1820827116.
Full textForce Aldred, Shelley, Andrew Boudreau, Ben Buelow, Starlynn Clarke, Kevin Dang, Laura Davison, Katherine Harris, et al. "Multispecific antibodies targeting CD38 show potent tumor-specific cytotoxicity." Journal of Clinical Oncology 36, no. 5_suppl (February 10, 2018): 57. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.57.
Full textChittasupho, Chuda, Teruna J. Siahaan, Charlotte M. Vines, and Cory Berkland. "Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics." Therapeutic Delivery 2, no. 7 (July 2011): 873–89. http://dx.doi.org/10.4155/tde.11.60.
Full textLiu, S. P., L. Zhou, R. Lakshminarayanan, and R. W. Beuerman. "Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities." International Journal of Peptide Research and Therapeutics 16, no. 3 (August 26, 2010): 199–213. http://dx.doi.org/10.1007/s10989-010-9230-z.
Full textRossi, Edmund A., David M. Goldenberg, Thomas M. Cardillo, Rhona Stein, Yang Wang, and Chien-Hsing Chang. "Novel Designs of Multivalent Anti-CD20 Humanized Antibodies as Improved Lymphoma Therapeutics." Cancer Research 68, no. 20 (October 15, 2008): 8384–92. http://dx.doi.org/10.1158/0008-5472.can-08-2033.
Full textToretsky, Jeffrey A., and Peter E. Wright. "Assemblages: Functional units formed by cellular phase separation." Journal of Cell Biology 206, no. 5 (September 1, 2014): 579–88. http://dx.doi.org/10.1083/jcb.201404124.
Full textBlanchard, Helen, Khuchtumur Bum-Erdene, and Matthew W. Hugo. "Inhibitors of Galectins and Implications for Structure-Based Design of Galectin-Specific Therapeutics." Australian Journal of Chemistry 67, no. 12 (2014): 1763. http://dx.doi.org/10.1071/ch14362.
Full textMiyashita, Shin-Ichiro, Jie Zhang, Sicai Zhang, Charles B. Shoemaker, and Min Dong. "Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism." Science Translational Medicine 13, no. 575 (January 6, 2021): eaaz4197. http://dx.doi.org/10.1126/scitranslmed.aaz4197.
Full textHeitner, Tara, Noboru Satozawa, Kirk Mclean, David Vogel, Ronald R. Cobb, Bing Liu, Mithra Mahmoudi, et al. "Obligate Multivalent Recognition of Cell Surface Tomoregulin following Selection from a Multivalent Phage Antibody Library." Journal of Biomolecular Screening 11, no. 8 (December 2006): 985–95. http://dx.doi.org/10.1177/1087057106293841.
Full textGao, Rachel Y., Christine M. Riley, Evan Toth, Rebecca H. Blair, Megan N. Gerold, Caitlin McCormick, Amber W. Taylor, Tianjing Hu, Kathy L. Rowlen, and Erica D. Dawson. "Rapid Identity and Quantity CQA Test for Multivalent mRNA Drug Product Formulations." Vaccines 10, no. 10 (October 12, 2022): 1704. http://dx.doi.org/10.3390/vaccines10101704.
Full textSalih, Suliman, Ajnas Alkatheeri, Wijdan Alomaim, and Aisyah Elliyanti. "Radiopharmaceutical Treatments for Cancer Therapy, Radionuclides Characteristics, Applications, and Challenges." Molecules 27, no. 16 (August 16, 2022): 5231. http://dx.doi.org/10.3390/molecules27165231.
Full textMarson, Domenico, Erik Laurini, Suzana Aulic, Maurizio Fermeglia, and Sabrina Pricl. "Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled In Silico-Experimental Studies. Part I: Covalent siRNA Nanocarriers." Pharmaceutics 11, no. 7 (July 18, 2019): 351. http://dx.doi.org/10.3390/pharmaceutics11070351.
Full textBrier, Livia, Amy A. Twite, Adam Barnebey, Mavish Mahomed, and Wesley M. Jackson. "Abstract 4157: Using a multivalent immunotherapy platform to extend intratumoral therapeutic durability." Cancer Research 82, no. 12_Supplement (June 15, 2022): 4157. http://dx.doi.org/10.1158/1538-7445.am2022-4157.
Full textSheikhi Mehrabadi, Fatemeh, Hanxiang Zeng, Mark Johnson, Cathleen Schlesener, Zhibin Guan, and Rainer Haag. "Multivalent dendritic polyglycerolamine with arginine and histidine end groups for efficient siRNA transfection." Beilstein Journal of Organic Chemistry 11 (May 13, 2015): 763–72. http://dx.doi.org/10.3762/bjoc.11.86.
Full textMousavifar, Leila, and René Roy. "Design, Synthetic Strategies, and Therapeutic Applications of Heterofunctional Glycodendrimers." Molecules 26, no. 9 (April 22, 2021): 2428. http://dx.doi.org/10.3390/molecules26092428.
Full textHuang, Y.-J., A.-L. Shiau, S.-Y. Chen, Y.-L. Chen, C.-R. Wang, C.-Y. Tsai, M.-Y. Chang, Y.-T. Li, C.-H. Leu, and C.-L. Wu. "Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering." European Cells and Materials 23 (March 13, 2012): 170–81. http://dx.doi.org/10.22203/ecm.v023a13.
Full textKalathiya, Umesh, Monikaben Padariya, Robin Fahraeus, Soumyananda Chakraborti, and Ted R. Hupp. "Multivalent Display of SARS-CoV-2 Spike (RBD Domain) of COVID-19 to Nanomaterial, Protein Ferritin Nanocages." Biomolecules 11, no. 2 (February 17, 2021): 297. http://dx.doi.org/10.3390/biom11020297.
Full textMajzoub, Ramsey N., Kai K. Ewert, and Cyrus R. Safinya. "Cationic liposome–nucleic acid nanoparticle assemblies with applications in gene delivery and gene silencing." Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 374, no. 2072 (July 28, 2016): 20150129. http://dx.doi.org/10.1098/rsta.2015.0129.
Full textSun, Yaping, and Mitchell Ho. "Emerging antibody-based therapeutics against SARS-CoV-2 during the global pandemic." Antibody Therapeutics 3, no. 4 (November 24, 2020): 246–56. http://dx.doi.org/10.1093/abt/tbaa025.
Full textSadeghnezhad, Golnaz, Ema Romão, Robert Bernedo-Navarro, Sam Massa, Khosro Khajeh, Serge Muyldermans, and Sadegh Hassania. "Identification of New DR5 Agonistic Nanobodies and Generation of Multivalent Nanobody Constructs for Cancer Treatment." International Journal of Molecular Sciences 20, no. 19 (September 27, 2019): 4818. http://dx.doi.org/10.3390/ijms20194818.
Full textIwasaki, Yasuhiko. "Bone Mineral Affinity of Polyphosphodiesters." Molecules 25, no. 3 (February 10, 2020): 758. http://dx.doi.org/10.3390/molecules25030758.
Full textLaurini, Erik, Domenico Marson, Suzana Aulic, Maurizio Fermeglia, and Sabrina Pricl. "Evolution from Covalent to Self-Assembled PAMAM-Based Dendrimers as Nanovectors for siRNA Delivery in Cancer by Coupled in Silico-Experimental Studies. Part II: Self-Assembled siRNA Nanocarriers." Pharmaceutics 11, no. 7 (July 10, 2019): 324. http://dx.doi.org/10.3390/pharmaceutics11070324.
Full textGillespie, James W., Liping Yang, Laura Maria De Plano, Murray A. Stackhouse, and Valery A. Petrenko. "Evolution of a Landscape Phage Library in a Mouse Xenograft Model of Human Breast Cancer." Viruses 11, no. 11 (October 26, 2019): 988. http://dx.doi.org/10.3390/v11110988.
Full textRossi, Edmund A., David M. Goldenberg, Thomas M. Cardillo, Rhona Stein, and Chien-Hsing Chang. "Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma." Blood 113, no. 24 (June 11, 2009): 6161–71. http://dx.doi.org/10.1182/blood-2008-10-187138.
Full textClua, Anna, Santiago Grijalvo, Namrata Erande, Swati Gupta, Kristina Yucius, Raimundo Gargallo, Stefania Mazzini, Muthiah Manoharan, and Ramon Eritja. "Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes." Molecules 27, no. 12 (June 20, 2022): 3944. http://dx.doi.org/10.3390/molecules27123944.
Full textKupihár, Zoltán, Györgyi Ferenc, Vencel L. Petrovicz, Viktória R. Fáy, Lajos Kovács, Tamás A. Martinek, and Zsófia Hegedüs. "Improved Metal-Free Approach for the Synthesis of Protected Thiol Containing Thymidine Nucleoside Phosphoramidite and Its Application for the Synthesis of Ligatable Oligonucleotide Conjugates." Pharmaceutics 15, no. 1 (January 11, 2023): 248. http://dx.doi.org/10.3390/pharmaceutics15010248.
Full textGambles, M. Tommy, Jiahui Li, Jiawei Wang, Douglas Sborov, Jiyuan Yang, and Jindřich Kopeček. "Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells." Molecules 26, no. 15 (July 31, 2021): 4658. http://dx.doi.org/10.3390/molecules26154658.
Full textLaird, Renee M., Christina L. Gariepy, Heather Eggleston, Nina M. Shoemaker, Mario A. Monteiro, Patricia Guerry, Zoltan Beck, Gary R. Matyas, and Frédéric Poly. "Application of a Campylobacter jejuni mouse infection model to test efficacy of a C. jejuni capsule conjugate vaccine delivered with a potent liposome adjuvant containing monophosphoryl lipid A and QS-21." Journal of Immunology 204, no. 1_Supplement (May 1, 2020): 168.20. http://dx.doi.org/10.4049/jimmunol.204.supp.168.20.
Full textNelissen, Frank H. T., Wenny J. M. Peeters, Timo P. Roelofs, Anika Nagelkerke, Paul N. Span, and Hans A. Heus. "Improving Breast Cancer Treatment Specificity Using Aptamers Obtained by 3D Cell-SELEX." Pharmaceuticals 14, no. 4 (April 9, 2021): 349. http://dx.doi.org/10.3390/ph14040349.
Full textWang, Jiawei, Lian Li, Jiyuan Yang, Phillip M. Clair, Martha Glenn, Deborah M. Stephens, D. Christopher Radford, et al. "Drug-Free Macromolecular Therapeutics Induce Apoptosis in Cells Isolated from Patients with B Cell Malignancies with Enhanced Apoptosis Induction By Pretreatment with Gemcitabine." Blood 132, Supplement 1 (November 29, 2018): 4426. http://dx.doi.org/10.1182/blood-2018-99-112001.
Full textGardiner, John M. "The therapeutic potential of synthetic multivalent carbohydrates." Expert Opinion on Investigational Drugs 7, no. 3 (March 1998): 405–11. http://dx.doi.org/10.1517/13543784.7.3.405.
Full textNeill, Thomas, Liliana Schaefer, and Renato V. Iozzo. "Decorin as a multivalent therapeutic agent against cancer." Advanced Drug Delivery Reviews 97 (February 2016): 174–85. http://dx.doi.org/10.1016/j.addr.2015.10.016.
Full textWang, Beatrice, Ling Wang, Tasnim Kothambawala, Susan Calhoun, Thomas Matthew, Genevive Hernandez, Marvin Peterson, Angus Sinclair, Eric William Humke, and Bruce Keyt. "IGM-8444 as a potent agonistic Death Receptor 5 (DR5) IgM antibody: Induction of tumor cytotoxicity, combination with chemotherapy and in vitro safety profile." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 3595. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3595.
Full textZhao, Jisi, Shuang Li, Yingying Jin, Jessica Wang, Wenjing Li, Wenjie Wu, and Zhangyong Hong. "Multimerization Increases Tumor Enrichment of Peptide–Photosensitizer Conjugates." Molecules 24, no. 4 (February 25, 2019): 817. http://dx.doi.org/10.3390/molecules24040817.
Full textRossi, Edmund A., Chien-Hsing Chang, Thomas M. Cardillo, Rhona Stein, Diana Pilas, Diane L. Nordstrom, John Kopinski, and David M. Goldenberg. "Bispecific Anti-CD20/Anti-CD22 Antibodies with Potent Lymphoma Cytotoxicity." Blood 112, no. 11 (November 16, 2008): 1591. http://dx.doi.org/10.1182/blood.v112.11.1591.1591.
Full textVorobyeva, Mariya, Pavel Vorobjev, and Alya Venyaminova. "Multivalent Aptamers: Versatile Tools for Diagnostic and Therapeutic Applications." Molecules 21, no. 12 (November 25, 2016): 1613. http://dx.doi.org/10.3390/molecules21121613.
Full textChittasupho, Chuda. "Multivalent ligand: design principle for targeted therapeutic delivery approach." Therapeutic Delivery 3, no. 10 (October 2012): 1171–87. http://dx.doi.org/10.4155/tde.12.99.
Full textRiccardi, Claudia, Ettore Napolitano, Domenica Musumeci, and Daniela Montesarchio. "Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition." Molecules 25, no. 22 (November 10, 2020): 5227. http://dx.doi.org/10.3390/molecules25225227.
Full textBartus, Éva, Gábor Olajos, Ildikó Schuster, Zsolt Bozsó, Mária Deli, Szilvia Veszelka, Fruzsina Walter, et al. "Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers." Molecules 23, no. 10 (October 2, 2018): 2523. http://dx.doi.org/10.3390/molecules23102523.
Full textJana, Batakrishna, Dongkap Kim, Huyeon Choi, Minsoo Kim, Kibeom Kim, Sangpil Kim, Seongeon Jin, et al. "Drug resistance-free cytotoxic nanodrugs in composites for cancer therapy." Journal of Materials Chemistry B 9, no. 14 (2021): 3143–52. http://dx.doi.org/10.1039/d0tb02850a.
Full textMallikaratchy, Prabodhika, Alessandro Ruggiero, William Maguire, Kelly Piersanti, Jeffrey Gardner, Carlos Villa, Freddy Escorcia, et al. "Multivalent DNA Aptamer-Based Therapeutic Agents for Lymphoma and Leukemia." Blood 114, no. 22 (November 20, 2009): 2711. http://dx.doi.org/10.1182/blood.v114.22.2711.2711.
Full textHall, Pamela R., Brian Hjelle, David C. Brown, Chunyan Ye, Virginie Bondu-Hawkins, Kathleen A. Kilpatrick, and Richard S. Larson. "Multivalent Presentation of Antihantavirus Peptides on Nanoparticles Enhances Infection Blockade." Antimicrobial Agents and Chemotherapy 52, no. 6 (April 7, 2008): 2079–88. http://dx.doi.org/10.1128/aac.01415-07.
Full textPopov, Jesse, Roger Gilabert-Oriol, and Marcel B. Bally. "Unique therapeutic properties and preparation methodology of multivalent rituximab-lipid nanoparticles." European Journal of Pharmaceutics and Biopharmaceutics 117 (August 2017): 256–69. http://dx.doi.org/10.1016/j.ejpb.2017.04.024.
Full textSheard, Dean E., Wenyi Li, Neil M. O’Brien-Simpson, Frances Separovic, and John D. Wade. "Peptide Multimerization as Leads for Therapeutic Development." Biologics 2, no. 1 (December 30, 2021): 15–44. http://dx.doi.org/10.3390/biologics2010002.
Full textShah, Sachit, and Lorraine Leon. "Structural transitions and encapsulation selectivity of thermoresponsive polyelectrolyte complex micelles." Journal of Materials Chemistry B 7, no. 41 (2019): 6438–48. http://dx.doi.org/10.1039/c9tb01194c.
Full textChiu, Gigi N. C., Lincoln A. Edwards, Anita I. Kapanen, Melina M. Malinen, Wieslawa H. Dragowska, Corinna Warburton, Ghania G. Chikh, et al. "Modulation of cancer cell survival pathways using multivalent liposomal therapeutic antibody constructs." Molecular Cancer Therapeutics 6, no. 3 (March 2007): 844–55. http://dx.doi.org/10.1158/1535-7163.mct-06-0159.
Full textMistry, Hitesh, Fernando Ortega, Fernando Ortega, Johanna Lahdenranta, Punit Upadhyaya, Kristen Hurov, Phil Jeffrey, and Christophe Chassagnole. "826 Establishing the preclinical/translational PK/PD relationship for BT7480, a nectin-4/CD137 Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA™)." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (November 2021): A865. http://dx.doi.org/10.1136/jitc-2021-sitc2021.826.
Full textManenkov, P. "On the treatment of puerperal sepsis by local interstitial vaccination. Spirit o (Zbl. F. Gyn., 1933, no. 33)." Kazan medical journal 29, no. 11-12 (January 12, 2022): 989. http://dx.doi.org/10.17816/kazmj90308.
Full textTan, Zhixin Cyrillus, Brian T. Orcutt-Jahns, and Aaron S. Meyer. "A quantitative view of strategies to engineer cell-selective ligand binding." Integrative Biology 13, no. 11 (November 2021): 269–82. http://dx.doi.org/10.1093/intbio/zyab019.
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