Academic literature on the topic 'Multivalent therapeutics'
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Journal articles on the topic "Multivalent therapeutics"
Farhadi, Shaheen A., and Gregory A. Hudalla. "Engineering galectin–glycan interactions for immunotherapy and immunomodulation." Experimental Biology and Medicine 241, no. 10 (May 2016): 1074–83. http://dx.doi.org/10.1177/1535370216650055.
Full textLee, JuYeon, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, et al. "Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1." Proceedings of the National Academy of Sciences 116, no. 18 (April 11, 2019): 8709–14. http://dx.doi.org/10.1073/pnas.1820827116.
Full textForce Aldred, Shelley, Andrew Boudreau, Ben Buelow, Starlynn Clarke, Kevin Dang, Laura Davison, Katherine Harris, et al. "Multispecific antibodies targeting CD38 show potent tumor-specific cytotoxicity." Journal of Clinical Oncology 36, no. 5_suppl (February 10, 2018): 57. http://dx.doi.org/10.1200/jco.2018.36.5_suppl.57.
Full textChittasupho, Chuda, Teruna J. Siahaan, Charlotte M. Vines, and Cory Berkland. "Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics." Therapeutic Delivery 2, no. 7 (July 2011): 873–89. http://dx.doi.org/10.4155/tde.11.60.
Full textLiu, S. P., L. Zhou, R. Lakshminarayanan, and R. W. Beuerman. "Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities." International Journal of Peptide Research and Therapeutics 16, no. 3 (August 26, 2010): 199–213. http://dx.doi.org/10.1007/s10989-010-9230-z.
Full textRossi, Edmund A., David M. Goldenberg, Thomas M. Cardillo, Rhona Stein, Yang Wang, and Chien-Hsing Chang. "Novel Designs of Multivalent Anti-CD20 Humanized Antibodies as Improved Lymphoma Therapeutics." Cancer Research 68, no. 20 (October 15, 2008): 8384–92. http://dx.doi.org/10.1158/0008-5472.can-08-2033.
Full textToretsky, Jeffrey A., and Peter E. Wright. "Assemblages: Functional units formed by cellular phase separation." Journal of Cell Biology 206, no. 5 (September 1, 2014): 579–88. http://dx.doi.org/10.1083/jcb.201404124.
Full textBlanchard, Helen, Khuchtumur Bum-Erdene, and Matthew W. Hugo. "Inhibitors of Galectins and Implications for Structure-Based Design of Galectin-Specific Therapeutics." Australian Journal of Chemistry 67, no. 12 (2014): 1763. http://dx.doi.org/10.1071/ch14362.
Full textMiyashita, Shin-Ichiro, Jie Zhang, Sicai Zhang, Charles B. Shoemaker, and Min Dong. "Delivery of single-domain antibodies into neurons using a chimeric toxin–based platform is therapeutic in mouse models of botulism." Science Translational Medicine 13, no. 575 (January 6, 2021): eaaz4197. http://dx.doi.org/10.1126/scitranslmed.aaz4197.
Full textHeitner, Tara, Noboru Satozawa, Kirk Mclean, David Vogel, Ronald R. Cobb, Bing Liu, Mithra Mahmoudi, et al. "Obligate Multivalent Recognition of Cell Surface Tomoregulin following Selection from a Multivalent Phage Antibody Library." Journal of Biomolecular Screening 11, no. 8 (December 2006): 985–95. http://dx.doi.org/10.1177/1087057106293841.
Full textDissertations / Theses on the topic "Multivalent therapeutics"
Alias, Nadiawati. "Multivalent sialic acid binding proteins as novel therapeutics for influenza and parainfluenza infection." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/4479.
Full textHolliger, Philipp. "Multivalent and bispecific antibody fragments from E.coli : new strategies for antibody-based diagnostics and therapeutics from bacteria /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=11012.
Full textHart, Nathaniel. "Combinatorial Targeting of the Glucagon-Like Peptide-1 And Sulfonylurea-1 Receptors Using a Complimentary Multivalent Glucagon-Like Peptide-1/Glibenclamide Ligand for the Improvement of β-Cell Targeting Agents and Diabetic Treatment." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/311363.
Full textAnanthakrishnan, Kameswari, and Kameswari Ananthakrishnan. "Improved β-Cell Targeting and Therapeutics Using Multivalent Glucagon-Like Peptide-1 (GLP-1) Linked to the α2AR Antagonist Yohimbine (YHB): Evaluating the Binding, Selectivity and Signaling." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/623004.
Full textReimann, Sabine [Verfasser]. "Multivalent Dendritic Polyglycerol Anions for Diagnostic and Therapeutic Applications / Sabine Reimann." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1137206640/34.
Full textSeifert, Oliver [Verfasser], and Roland [Akademischer Betreuer] Kontermann. "TRAIL-based multivalent and multifunctional fusion proteins and liposomes for therapeutic applications / Oliver Seifert. Betreuer: Roland Kontermann." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2014. http://d-nb.info/1056910585/34.
Full textJosan, Jatinder Singh. "Heteromultivalent Ligands Directed Targeting of Cell-Surface Receptors - Implications in Cancer Diagnostics and Therapeutics." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/193592.
Full text"Application of Multivalent Interactions for Recognition Imaging and Delivery of Therapeutics." Doctoral diss., 2016. http://hdl.handle.net/2286/R.I.39432.
Full textDissertation/Thesis
Doctoral Dissertation Chemistry 2016
Yen-JangHuang and 黃彥彰. "Multivalent structure of nanogold-galectin-1 complex regulates apoptosis signaling and therapeutic effects in collagen-induced arthritis." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/16305030326752905343.
Full text國立成功大學
基礎醫學研究所
100
Cellular behaviour is controlled by numerous processes, including intracellular signaling pathways that are triggered by the binding of ligands with cell surface receptors. Multivalent ligands have multiple copies of a recognition element that binds to receptors and influences downstream signals. Gold nanoparticles are now highly utilized in chemistry, biology, engineering, and medicine. Gold nanoparticle-ligand complexes form multivalent structures to crosslink receptors with high avidity and specificity. Galectin-1 has high affinity for β-galactosides and engages with cell surface receptor to deliver a variety of intracellular signals. Galectin-1 induces apoptosis of specific thymocyte subsets and activates T cells. Here, we developed nanogold-galectin-1 (Au-Gal1) complexes with multivalent structure and expect the multivalent property of Au-Gal1 complexes will have more therapeutic potential than free-form galectin-1 or nanogold for rheumatoid arthritis. After conjugation onto gold nanoparticles, galectin-1 (Au-Gal1) bound with higher affinity to Jurkat cells to promote CD45 clustering and inhibition of its phosphatase activity, resulting in enhancement of apoptosis via caspase-dependent pathways. Au-Gal1 injected intra-articularly into rats with collagen induced arthritis (CIA) promoted apoptosis of CD4+ T cells and reduced pro-inflammatory cytokine levels in the ankle joints as well as ameliorated clinical symptoms of arthritis. These observed therapeutic effects indicate that the multivalent structure of nanoparticle-ligands can regulate the distribution of cell surface receptors and subsequent intracellular signalling, and this may provide new insights into nanoparticle applications.
Book chapters on the topic "Multivalent therapeutics"
Sharma, Shubh D., Victor J. Hruby, Mac E. Hadley, Michael E. Granberry, and Stanley P. L. Leong. "Multivalent ligands for diagnosis and therapeutics." In Peptides, 599–600. Dordrecht: Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_236.
Full textLiu, Cassie J., and Jennifer R. Cochran. "Engineering Multivalent and Multispecific Protein Therapeutics." In Engineering in Translational Medicine, 365–96. London: Springer London, 2013. http://dx.doi.org/10.1007/978-1-4471-4372-7_14.
Full textReina, Jose J., and Javier Rojo. "Carbohydrate Multivalent Systems: Synthesis and Therapeutic Opportunities." In Carbohydrate Chemistry: State of the Art and Challenges for Drug Development, 419–39. IMPERIAL COLLEGE PRESS, 2015. http://dx.doi.org/10.1142/9781783267200_0017.
Full textConference papers on the topic "Multivalent therapeutics"
Brier, Livia W., Mavish Mahomed, Amy A. Twite, Adam Barnebey, and Wesley M. Jackson. "Abstract P027: Extending intratumoral therapeutic durability using a multivalent immunotherapy platform." In Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy; October 5-6, 2021. American Association for Cancer Research, 2022. http://dx.doi.org/10.1158/2326-6074.tumimm21-p027.
Full textLiu, Yaling, Jifu Tan, and Samar Shah. "A Hybrid Model for Nanoparticle Targeted Delivery in Blood Flow." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13253.
Full textLapitsky, Yakov, Sabrina Alam, Udaka de Silva, Jennifer Brown, Carolina Mather, and Youngwoo Seo. "Surfactant-loaded Polyelectrolyte/multivalent Ion Coacervates for the Multi-month Release of Antibacterial and Therapeutic Payloads." In Virtual 2021 AOCS Annual Meeting & Expo. American Oil Chemists' Society (AOCS), 2021. http://dx.doi.org/10.21748/am21.267.
Full textDevi, Sarangthem V., Yun Jae Kim, Young-Jin Lee, Kuen Hur, Byung-Heon Lee, and Rang Woon Park. "Abstract 4538: Multivalent targeting based delivery of therapeutic peptide using AP1-ELP carrier for effective cancer therapy." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4538.
Full textLaust, Amanda K., Mikayel Mkrtichyan, Hayk Davtyan, Jivan Khlgatyan, Anahit Ghochikyan, Han Liu, Michael G. Agadjanyan, and Edward L. Nelson. "Abstract 4766: Multivalent VRP-based anti-tumor immunotherapy is an effective therapeutic strategy in a rat model of breast cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4766.
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