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Journal articles on the topic 'Multivalent recognition'

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Author: Grafiati

Published: 11 March 2023

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1

Heitner, Tara, Noboru Satozawa, Kirk Mclean, David Vogel, Ronald R. Cobb, Bing Liu, Mithra Mahmoudi, et al. "Obligate Multivalent Recognition of Cell Surface Tomoregulin following Selection from a Multivalent Phage Antibody Library." Journal of Biomolecular Screening 11, no. 8 (December 2006): 985–95. http://dx.doi.org/10.1177/1087057106293841.

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A therapeutic antibody candidate (AT-19) isolated using multivalent phage display binds native tomoregulin (TR) as a mul-timer not as a monomer. This report raises the importance of screening and selecting phage antibodies on native antigen and reemphasizes the possibility that potentially valuable antibodies are discarded when a monomeric phage display system is used for screening. A detailed live cell panning selection and screening method to isolate multivalently active antibodies is described. AT-19 is a fully human antibody recognizing the cell surface protein TR, a proposed prostate cancer target for therapeutic antibody internalization. AT-19 was isolated from a multivalent single-chain variable fragment (scFv) antibody library rescued with hyperphage. The required multivalency for isolation of AT-19 is supported by fluorescence activated cell sorting data demonstrating binding of the multivalent AT-19 phage particles at high phage concentrations and failure of monovalent particles to bind. Pure monomeric scFv AT-19 does not bind native receptor on cells, whereas dimeric scFv or immunoglobulin G binds with nanomolar affinity. The isolation of AT-19 antibody with obligate bivalent binding activity to native TR is attributed to the use of a multivalent display of scFv on phage and the method for selecting and screening by alternate use of 2 recombinant cell lines.

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2

Kim, Hokyung, Hayeon Choi, Yoonji Heo, Cheoljae Kim, Min Kim, and Ki Tae Kim. "Biosensors Based on Bivalent and Multivalent Recognition by Nucleic Acid Scaffolds." Applied Sciences 12, no. 3 (February 7, 2022): 1717. http://dx.doi.org/10.3390/app12031717.

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Several biological macromolecules adopt bivalent or multivalent interactions to perform various cellular processes. In this regard, the development of molecular constructs presenting multiple ligands in a specific manner is becoming crucial for the understanding of multivalent interactions and for the detection of target macromolecules. Nucleic acids are attractive molecules to achieve this goal because they are capable of forming various, structurally well-defined 2D or 3D nanostructures and can bear multiple ligands on their structures with precisely controlled ligand–ligand distances. Thanks to the features of nucleic acids, researchers have proposed a wide range of bivalent and multivalent binding agents that strongly bind to target biomolecules; consequently, these findings have uncovered new biosensing strategies for biomolecule detection. To date, various bivalent and multivalent interactions of nucleic acid architectures have been applied to the design of biosensors with enhanced sensitivity and target accuracy. In this review, we describe not only basic biosensor designs but also recently designed biosensors operating through the bivalent and multivalent recognition of nucleic acid scaffolds. Based on these designs, strategies to transduce bi- or multivalent interaction signals into readable signals are discussed in detail, and the future prospects and challenges of the field of multivalence-based biosensors are explored.

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3

Ciuk, Anna K., and Thisbe K. Lindhorst. "Synthesis of carbohydrate-scaffolded thymine glycoconjugates to organize multivalency." Beilstein Journal of Organic Chemistry 11 (May 7, 2015): 668–74. http://dx.doi.org/10.3762/bjoc.11.75.

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Multivalency effects are essential in carbohydrate recognition processes as occurring on the cell surface. Thus many synthetic multivalent glycoconjugates have been developed as important tools for glycobiological research. We are expanding this collection of molecules by the introduction of carbohydrate-scaffolded divalent glycothymine derivatives that can be intramolecularily dimerized by [2 + 2] photocycloaddition. Thus, thymine functions as a control element that allows to restrict the conformational flexibility of the scaffolded sugar ligands and thus to “organize” multivalency. With this work we add a parameter to multivalency studies additional to valency.

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4

Lim, Choon Woo, Bart Jan Ravoo, and David N. Reinhoudt. "Dynamic multivalent recognition of cyclodextrin vesicles." Chemical Communications, no. 45 (2005): 5627. http://dx.doi.org/10.1039/b510540d.

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5

Mahon, Eugene, Teodor Aastrup, and Mihail Barboiu. "Multivalent recognition of lectins by glyconanoparticle systems." Chemical Communications 46, no. 30 (2010): 5491. http://dx.doi.org/10.1039/c002652b.

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6

Mouline, Zineb, Eugene Mahon, Emeline Gomez, Veronique Barragan-Montero, Jean-Louis Montero, and Mihail Barboiu. "Entropy-driven lectin-recognition of multivalent glycovesicles." Chem. Commun. 50, no. 6 (2014): 731–33. http://dx.doi.org/10.1039/c3cc47941b.

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7

Fiore, Michele, Nathalie Berthet, Olivier Renaudet, and Valessa Barbier. "New glycopolymers as multivalent systems for lectin recognition." MedChemComm 5, no. 8 (2014): 1202–7. http://dx.doi.org/10.1039/c4md00097h.

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8

Riccardi, Claudia, Ettore Napolitano, Domenica Musumeci, and Daniela Montesarchio. "Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition." Molecules 25, no. 22 (November 10, 2020): 5227. http://dx.doi.org/10.3390/molecules25225227.

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Multivalent interactions frequently occur in biological systems and typically provide higher binding affinity and selectivity in target recognition than when only monovalent interactions are operative. Thus, taking inspiration by nature, bivalent or multivalent nucleic acid aptamers recognizing a specific biological target have been extensively studied in the last decades. Indeed, oligonucleotide-based aptamers are suitable building blocks for the development of highly efficient multivalent systems since they can be easily modified and assembled exploiting proper connecting linkers of different nature. Thus, substantial research efforts have been put in the construction of dimeric/multimeric versions of effective aptamers with various degrees of success in target binding affinity or therapeutic activity enhancement. The present review summarizes recent advances in the design and development of dimeric and multimeric DNA-based aptamers, including those forming G-quadruplex (G4) structures, recognizing different key proteins in relevant pathological processes. Most of the designed constructs have shown improved performance in terms of binding affinity or therapeutic activity as anti-inflammatory, antiviral, anticoagulant, and anticancer agents and their number is certainly bound to grow in the next future.

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9

Lee, JuYeon, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, et al. "Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1." Proceedings of the National Academy of Sciences 116, no. 18 (April 11, 2019): 8709–14. http://dx.doi.org/10.1073/pnas.1820827116.

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Developing highly active, multivalent ligands as therapeutic agents is challenging because of delivery issues, limited cell permeability, and toxicity. Here, we report intrinsically cell-penetrating multivalent ligands that target the trinucleotide repeat DNA and RNA in myotonic dystrophy type 1 (DM1), interrupting the disease progression in two ways. The oligomeric ligands are designed based on the repetitive structure of the target with recognition moieties alternating with bisamidinium groove binders to provide an amphiphilic and polycationic structure, mimicking cell-penetrating peptides. Multiple biological studies suggested the success of our multivalency strategy. The designed oligomers maintained cell permeability and exhibited no apparent toxicity both in cells and in mice at working concentrations. Furthermore, the oligomers showed important activities in DM1 cells and in a DM1 liver mouse model, reducing or eliminating prominent DM1 features. Phenotypic recovery of the climbing defect in adult DM1Drosophilawas also observed. This design strategy should be applicable to other repeat expansion diseases and more generally to DNA/RNA-targeted therapeutics.

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10

Carroll, Joseph, Mark Gray, Kevin Bardon, Hiroshi Nakade, and Vincent Rotello. "Multivalent Recognition of Flavin Derivatives Using Polymer Scaffolds." Letters in Organic Chemistry 1, no. 3 (July 1, 2004): 227–30. http://dx.doi.org/10.2174/1570178043400974.

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11

Won, Sangho, Sarah-Jane Richards, Marc Walker, and Matthew I. Gibson. "Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition." Nanoscale Horizons 2, no. 2 (2017): 106–9. http://dx.doi.org/10.1039/c6nh00202a.

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12

Li, Yu-Hao, Yan Zhang, Yves-Marie Legrand, Arie van der Lee, Ji-Jun Jiang, Cheng-Xia Chen, Cheng-Yong Su, and Mihail Barboiu. "Hydrophobic metallo-supramolecular Pd2L4 cages for zwitterionic guest encapsulation in organic solvents." Dalton Transactions 46, no. 44 (2017): 15204–7. http://dx.doi.org/10.1039/c7dt03517a.

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13

Ehrmann, Svenja, Chih-Wei Chu, Shalini Kumari, Kim Silberreis, Christoph Böttcher, Jens Dernedde, Bart Jan Ravoo, and Rainer Haag. "A toolbox approach for multivalent presentation of ligand–receptor recognition on a supramolecular scaffold." Journal of Materials Chemistry B 6, no. 25 (2018): 4216–22. http://dx.doi.org/10.1039/c8tb00922h.

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14

Carta, Fabrizio, Pascal Dumy, Claudiu T. Supuran, and Jean-Yves Winum. "Multivalent Carbonic Anhydrases Inhibitors." International Journal of Molecular Sciences 20, no. 21 (October 28, 2019): 5352. http://dx.doi.org/10.3390/ijms20215352.

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Biomolecular recognition using a multivalent strategy has been successfully applied, this last decade on several biological targets, especially carbohydrate-processing enzymes, proteases, and phosphorylases. This strategy is based on the fact that multivalent interactions of several inhibitory binding units grafted on a presentation platform may enhance the binding affinity and selectivity. The zinc metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) are considered as drug targets for several pathologies, and different inhibitors found clinical applications as diuretics, antiglaucoma agents, anticonvulsants, and anticancer agents/diagnostic tools. Their main drawback is related to the lack of isoform selectivity leading to serious side effects for all pathologies in which they are employed. Thus, the multivalent approach may open new opportunities in the drug design of innovative isoform-selective carbonic anhydrase inhibitors with biomedical applications.

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15

Scheibe, Christian, and Oliver Seitz. "PNA–sugar conjugates as tools for the spatial screening of carbohydrate–lectin interactions." Pure and Applied Chemistry 84, no. 1 (December 8, 2011): 77–85. http://dx.doi.org/10.1351/pac-con-11-08-07.

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Multivalent carbohydrate–lectin interactions are essential for a multitude of biological recognition events. Much effort has been spent in the synthesis of potent multivalent scaffolds in order to mimic or inhibit biological carbohydrate–protein interactions. However, the defined spatial presentation of carbohydrates remained a challenging task. Peptide nucleic acid (PNA)- and DNA-based double helices are useful scaffolds that enable the controlled display of carbohydrate ligands in a modular approach. The hybridization of PNA-sugar conjugates with complementary DNA strands provides multivalent complexes with defined spatial presentation of carbohydrates, which facilitates the spatial screening of carbohydrate–lectin interactions with Ångström-scale precision.

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16

Rambob, Rajeev. "Multivalent masculinity and #MeToo." Review & Expositor 117, no. 2 (May 2020): 235–42. http://dx.doi.org/10.1177/0034637320925395.

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The deadly combination of male supremacy and toxic masculinity (MSTM) systemically and culturally promotes, supports, and defends violence against women, girls, femmes, and “lesser” men. This article provides working definitions for male supremacy and toxic masculinity and explores the damage they can do on their own and when combined. Multivalent masculinity offers a new way to navigate gender identity and expression by allowing for a spectrum of experiences. The infographic of the gender unicorn, developed by Trans Student Educational Resources, is a useful tool for “men’s” groups to employ as they seek to cultivate multivalent masculinity. The most important work of multivalent masculinity is: (i) to break open the definition, understanding, and recognition of what it means to “be a man”; (ii) to be painfully cognizant of the harm done by MSTM; and (iii) actively to resist being shackled or defined by MSTM.

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17

Li, Yan-Mei, Pu-Guang Chen, Zhi-Hua Huang, Zhan-Yi Sun, Qian-Qian Li, Yong-Xiang Chen, and Yu-Fen Zhao. "Synthesis of an MUC1 Glycopeptide Dendrimer Based on β-Cyclodextrin by Click Chemistry." Synlett 28, no. 15 (July 6, 2017): 1961–65. http://dx.doi.org/10.1055/s-0036-1590796.

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Glycopeptide dendrimers are attractive candidates for biomedical applications. Here, an efficient method for preparing multivalent MUC1 glycopeptide dendrimers based on β-cyclodextrin is described. By using copper(I) bromide and thioanisole as a catalyst system, precisely defined heptavalent conjugates were efficiently obtained. Using this heptavalent glycopeptide dendrimer, we observed multivalent effects in recognition and association processes in antibody and epitope interactions, which might have biomedical applications.

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18

Chen, Xiaojiao, Yao He, Youyu Zhang, Meiling Liu, Yang Liu, and Jinghong Li. "Ultrasensitive detection of cancer cells and glycan expression profiling based on a multivalent recognition and alkaline phosphatase-responsive electrogenerated chemiluminescence biosensor." Nanoscale 6, no. 19 (2014): 11196–203. http://dx.doi.org/10.1039/c4nr03053b.

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19

Brekalo, Jasna, Guillaume Despras, and Thisbe K. Lindhorst. "Pseudoenantiomeric glycoclusters: synthesis and testing of heterobivalency in carbohydrate–protein interactions." Organic & Biomolecular Chemistry 17, no. 24 (2019): 5929–42. http://dx.doi.org/10.1039/c9ob00124g.

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20

Kauscher, Ulrike, and Bart Jan Ravoo. "Mannose-decorated cyclodextrin vesicles: The interplay of multivalency and surface density in lectin–carbohydrate recognition." Beilstein Journal of Organic Chemistry 8 (September 17, 2012): 1543–51. http://dx.doi.org/10.3762/bjoc.8.175.

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Cyclodextrin vesicles are versatile models for biological cell membranes since they provide a bilayer membrane that can easily be modified by host–guest interactions with functional guest molecules. In this article, we investigate the multivalent interaction of the lectin concanavalin A (ConA) with cyclodextrin vesicles decorated with mannose–adamantane conjugates with one, two or three adamantane units as well as one or two mannose units. The carbohydrate–lectin interaction in this artificial, self-assembled glycocalyx was monitored in an agglutination assay by the increase of optical density at 400 nm. It was found that there is a close relation between the carbohydrate density at the cyclodextrin vesicle surface and the multivalent interaction with ConA, and the most efficient interaction (i.e., fastest agglutination at lowest concentration) was observed for mannose–adamantane conjugates, in which both the cyclodextrin–adamantane and the lectin–mannose interaction is inherently multivalent.

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21

Guo, Yuna, Yu Wang, Su Liu, Jinghua Yu, Hongzhi Wang, Min Cui, and Jiadong Huang. "Electrochemical immunosensor assay (EIA) for sensitive detection of E. coli O157:H7 with signal amplification on a SG–PEDOT–AuNPs electrode interface." Analyst 140, no. 2 (2015): 551–59. http://dx.doi.org/10.1039/c4an01463d.

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22

Hollenbeck, Jessica J., Derek J. Danner, Rachel M. Landgren, Thomas K. Rainbolt, and Danielle S. Roberts. "Designed Ankyrin Repeat Proteins as Scaffolds for Multivalent Recognition." Biomacromolecules 13, no. 7 (June 21, 2012): 1996–2002. http://dx.doi.org/10.1021/bm300455f.

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23

Snyder, Greta Fowler. "Multivalent Recognition: Between Fixity and Fluidity in Identity Politics." Journal of Politics 74, no. 1 (January 2012): 249–61. http://dx.doi.org/10.1017/s0022381611001563.

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24

Reczek, Joseph J., Aimee A. Kennedy, Brian T. Halbert, and Adam R. Urbach. "Multivalent Recognition of Peptides by Modular Self-Assembled Receptors." Journal of the American Chemical Society 131, no. 6 (February 18, 2009): 2408–15. http://dx.doi.org/10.1021/ja808936y.

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25

Schamel, Wolfgang W. A., Ignacio Arechaga, Ruth M. Risueño, Hisse M. van Santen, Pilar Cabezas, Cristina Risco, José M. Valpuesta, and Balbino Alarcón. "Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response." Journal of Experimental Medicine 202, no. 4 (August 8, 2005): 493–503. http://dx.doi.org/10.1084/jem.20042155.

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A long-standing paradox in the study of T cell antigen recognition is that of the high specificity–low affinity T cell receptor (TCR)–major histocompatibility complex peptide (MHCp) interaction. The existence of multivalent TCRs could resolve this paradox because they can simultaneously improve the avidity observed for monovalent interactions and allow for cooperative effects. We have studied the stoichiometry of the TCR by Blue Native–polyacrylamide gel electrophoresis and found that the TCR exists as a mixture of monovalent (αβγεδεζζ) and multivalent complexes with two or more ligand-binding TCRα/β subunits. The coexistence of monovalent and multivalent complexes was confirmed by electron microscopy after label fracture of intact T cells, thus ruling out any possible artifact caused by detergent solubilization. We found that although only the multivalent complexes become phosphorylated at low antigen doses, both multivalent and monovalent TCRs are phosphorylated at higher doses. Thus, the multivalent TCRs could be responsible for sensing low concentrations of antigen, whereas the monovalent TCRs could be responsible for dose-response effects at high concentrations, conditions in which the multivalent TCRs are saturated. Thus, besides resolving TCR stoichiometry, these data can explain how T cells respond to a wide range of MHCp concentrations while maintaining high sensitivity.

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26

Chan, Ching W., Erik Laurini, Paola Posocco, Sabrina Pricl, and David K. Smith. "Chiral recognition at self-assembled multivalent (SAMul) nanoscale interfaces – enantioselectivity in polyanion binding." Chemical Communications 52, no. 69 (2016): 10540–43. http://dx.doi.org/10.1039/c6cc04470k.

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We investigate structure–activity effect relationships at the nanoscale chiral molecular recognition interface between enantiomeric self-assembled multivalent (SAMul) systems and biological polyanions, heparin and DNA.

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27

Illescas Martínez, Beatriz M., Jennifer Patino-Alonso, Gema Nieto-Ortiz, Justo Cabrera-González, and Nazario Martín. "(Invited) Multivalent [60]Fullerene Hexakis-Adducts for Biomedical Applications." ECS Meeting Abstracts MA2022-01, no. 8 (July 7, 2022): 696. http://dx.doi.org/10.1149/ma2022-018696mtgabs.

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Now more than ever we are aware of the need of development of new antiviral materials to fight off unknown virus and overcome the multidrug resistance shown by different pathogens. Such resistance is considered a public health threat and the WHO predicted millions of deaths during the next years caused by resistant microorganisms. Carbon based nanomaterials hold promise for alternative and innovative approaches as they are biodegradable and biocompatible materials with unique tunable optical, electronic and mechanical properties. Many biological recognition processes take advantage of multivalency to enhance weak ligand-receptor affinities. Typical important multivalent interactions are the protein-carbohydrate recognition involved in viral entry, cell surface adhesion, and host-pathogen interactions. Among the carbon based nanomaterials, [60]fullerene constitutes a privileged scaffold with a highly symmetrical and rigid nanosized structure. We have modified it to form hexakis-adducts with octahedral geometry for the multivalent presentation of carbohydrates or amino acids.1,2 Tridecafullerenes constructed by a central [60]fullerene scaffold surrounded by other twelve fullerene units endowed with up to 360 disaccharides have been synthesized and studied in viral infection inhibition biological assays. These systems have shown a remarkable efficiency in the inhibition of the infectious process by Ebola, Zika and Dengue viruses, with IC50 values in the picomolar range.3 New multivalent nanostructures with different topology and/or fluorescent platforms are currently being synthesized and evaluated in our group. The latest results will be presented. References: [1] Muñoz, A.; Sigwalt, D.; Illescas, B. M.; Luczkowiak, J.; Rodríguez-Pérez, L.; Nierengarten, I.; Holler, M.; Remy, J.-S.; Buffet, K.; Vincent, S. P.; Rojo, J.; Delgado, R.; Nierengarten, J.-F.; Martín, N. Nat. Chem., 2016, 8, 50-57. [2] Ruiz-Santaquiteria, M.; Illescas, B. M.; Abdelnabi, R.; Boonen, A.; Mills, A.; Martí-Marí, O.; Noppen, S.; Neyts, J.; Schols, D.; Gago, F.; San-Félix, A.; Camarasa, M. J., Martín, N. Chem. Eur. J. 2021, 27, 10700–10710. [3] Ramos-Soriano, J.; Reina, J. J.; Illescas, B. M.; De La Cruz, N.; Rodríguez-Pérez, L.; Lasala, F.; Rojo, J.; Delgado, R.; Martín, N. J. Am. Chem. Soc. 2019, 141, 15403-15412.

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28

Kurlemann, Michael, and Bart Jan Ravoo. "Towards the sequence-specific multivalent molecular recognition of cyclodextrin oligomers." Beilstein Journal of Organic Chemistry 10 (October 20, 2014): 2428–40. http://dx.doi.org/10.3762/bjoc.10.253.

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Sequence-specific multivalent molecular recognition has been recognized to play a major role in biological processes. Furthermore, sequence-specific recognition motifs have been used in various artificial systems in the last years, e.g., to emulate biological processes or to build up new materials with highly specific recognition domains. In this article, we present the preparation of cyclodextrin (CD)-based strands and complementary and non-complementary strands modified with guest molecules and the investigation of their complexation behavior towards each other by isothermal titration calorimetry (ITC). As complementary binding motifs n-butyl and α-CD and adamantane and β-CD were selected. It was found that it is possible to realize sequence-specific molecular recognition by the use of host–guest chemistry, but the recognition motifs as well as the linkages have to be chosen very carefully. In the case of trivalent systems one adamantane moiety must be included to induce preferred formation of 1:1 adducts. Due to the too weak interaction between n-butyl and α-CD these systems have a negative chelate cooperativity and open adducts are preferentially formed. As soon as two adamantane moieties are present, the complementary systems have a positive chelate cooperativity and double-stranded structures are favored over open adducts. In this system the n-butyl moiety provides insufficient discrimination towards α- and β-CD and no sequence specificity is observed. By the combination of three adamantane moieties sequence specificity can be generated. Exclusively with the complementary CD sequence double-stranded structures are formed, with non-complementary strands aggregates of higher stoichiometry are generated.

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29

Giuliani, Marta, Ilaria Morbioli, Francesco Sansone, and Alessandro Casnati. "Moulding calixarenes for biomacromolecule targeting." Chemical Communications 51, no. 75 (2015): 14140–59. http://dx.doi.org/10.1039/c5cc05204a.

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The main rules that can be used to mould multivalent calixarene macrocycles for obtaining efficient and successful ligands for biomacromolecule recognition are outlined and described with the help of selected literature examples.

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30

Kang, Tae Woog, In‐Jun Hwang, Sin Lee, Su‐Ji Jeon, Chanhee Choi, Juhee Han, Yoonhee So, et al. "Multivalent Nanosheet Antibody Mimics for Selective Microbial Recognition and Inactivation." Advanced Materials 33, no. 22 (April 23, 2021): 2101376. http://dx.doi.org/10.1002/adma.202101376.

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31

Sansone, Francesco, Laura Baldini, Alessandro Casnati, and Rocco Ungaro. "Calixarenes: from biomimetic receptors to multivalent ligands for biomolecular recognition." New Journal of Chemistry 34, no. 12 (2010): 2715. http://dx.doi.org/10.1039/c0nj00285b.

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32

Yu, Lei, Mingchuan Huang, Peng G. Wang, and Xiangqun Zeng. "Cross-Linked Surface-Grafted Glycopolymer for Multivalent Recognition of Lectin." Analytical Chemistry 79, no. 23 (December 2007): 8979–86. http://dx.doi.org/10.1021/ac071453q.

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33

Battigelli, Alessia, Jae Hong Kim, Dilani C. Dehigaspitiya, Caroline Proulx, Ellen J. Robertson, Daniel J. Murray, Behzad Rad, Kent Kirshenbaum, and Ronald N. Zuckermann. "Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition." ACS Nano 12, no. 3 (March 7, 2018): 2455–65. http://dx.doi.org/10.1021/acsnano.7b08018.

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34

Garnham, Christopher P., Annapurna Vemu, Elizabeth M. Wilson-Kubalek, Ian Yu, Agnieszka Szyk, Gabriel C. Lander, Ronald A. Milligan, and Antonina Roll-Mecak. "Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases." Cell 161, no. 5 (May 2015): 1112–23. http://dx.doi.org/10.1016/j.cell.2015.04.003.

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35

Branderhorst, Hilbert M., Rob Ruijtenbeek, Rob M. J. Liskamp, and Roland J. Pieters. "Multivalent Carbohydrate Recognition on a Glycodendrimer‐Functionalized Flow‐Through Chip." ChemBioChem 9, no. 11 (July 21, 2008): 1836–44. http://dx.doi.org/10.1002/cbic.200800195.

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36

Liang, X., and M. Bonizzoni. "Boronic acid-modified poly(amidoamine) dendrimers as sugar-sensing materials in water." Journal of Materials Chemistry B 4, no. 18 (2016): 3094–103. http://dx.doi.org/10.1039/c5tb02530c.

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High-affinity carbohydrate receptors were developed by appending boronic acids to the surface of PAMAM dendrimers. These multivalent hosts were used to discriminate simple sugars in neat water using pattern recognition and optical spectroscopy techniques.

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37

Pawar, Nitin J., Ulf Diederichsen, and Dilip D. Dhavale. "Correction: Multivalent presentation of carbohydrates by 314-helical peptide templates: synthesis, conformational analysis using CD spectroscopy and saccharide recognition." Organic & Biomolecular Chemistry 14, no. 2 (2016): 785. http://dx.doi.org/10.1039/c5ob90206a.

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Correction for ‘Multivalent presentation of carbohydrates by 3₁₄-helical peptide templates: synthesis, conformational analysis using CD spectroscopy and saccharide recognition’ by Nitin J. Pawar et al., Org. Biomol. Chem., 2015, 13, 11278–11285.

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38

Saliba, Daniel, Tuan Trinh, Christophe Lachance-Brais, Alexander L. Prinzen, Felix J. Rizzuto, Donatien de Rochambeau, and Hanadi F. Sleiman. "Asymmetric patterning drives the folding of a tripodal DNA nanotweezer." Chemical Science 13, no. 1 (2022): 74–80. http://dx.doi.org/10.1039/d1sc04793k.

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An extended, multivalent DNA nanotweezer that undergoes large-scale molecular motion upon protein recognition is presented. Our method based on “printing-elongation-folding” combines the DNA-minimal aspect of DNA tile-based assembly, with complexity of DNA origami.

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39

Ortega, Gabriela, and Alexander Briceño. "Template-stereocontrolled [2 + 2] photoreactions directed by surface recognition on hydrophilic functionalized carbon materials." CrystEngComm 20, no. 21 (2018): 2932–39. http://dx.doi.org/10.1039/c7ce01090g.

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Supramolecular assistance either in solution or in the solid state to the regioselective synthesis of single photodimers from [2 + 2] photoreactions surface-directed by multivalent H-bonding exo-templates based on hydrophilic carbon nanomaterials is shown.

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Pawar, Nitin J., Ulf Diederichsen, and Dilip D. Dhavale. "Multivalent presentation of carbohydrates by 314-helical peptide templates: synthesis, conformational analysis using CD spectroscopy and saccharide recognition." Organic & Biomolecular Chemistry 13, no. 46 (2015): 11278–85. http://dx.doi.org/10.1039/c5ob01673h.

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41

Zhang, Yin, Xiaojin He, Rebecca Zhuo, Ruojie Sha, Jasna Brujic, Nadrian C. Seeman, and Paul M. Chaikin. "Multivalent, multiflavored droplets by design." Proceedings of the National Academy of Sciences 115, no. 37 (August 27, 2018): 9086–91. http://dx.doi.org/10.1073/pnas.1718511115.

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Nature self-assembles functional materials by programming flexible linear arrangements of molecules and then folding them to make 2D and 3D objects. To understand and emulate this process, we have made emulsion droplets with specific recognition and controlled valence. Uniquely monovalent droplets form dimers: divalent lead to polymer-like chains, trivalent allow for branching, and programmed mixtures of different valences enable a variety of designed architectures and the ability to subsequently close and open structures. Our functional building blocks are a hybrid of micrometer-scale emulsion droplets and nanoscale DNA origami technologies. Functional DNA origami rafts are first added to droplets and then herded into a patch using specifically designated “shepherding” rafts. Additional patches with the same or different specificities can be formed on the same droplet, programming multiflavored, multivalence droplets. The mobile patch can bind to a patch on another droplet containing complementary functional rafts, leading to primary structure formation. Further binding of nonneighbor droplets can produce secondary structures, a third step in hierarchical self-assembly. The use of mobile patches rather than uniform DNA coverage has the advantage of valence control at the expense of slow kinetics. Droplets with controlled flavors and valences enable a host of different material and device architectures.

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Guo, Yuan, Inga Nehlmeier, Emma Poole, Chadamas Sakonsinsiri, Nicole Hondow, Andy Brown, Qing Li, et al. "Dissecting Multivalent Lectin–Carbohydrate Recognition Using Polyvalent Multifunctional Glycan-Quantum Dots." Journal of the American Chemical Society 139, no. 34 (August 17, 2017): 11833–44. http://dx.doi.org/10.1021/jacs.7b05104.

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Lauer, Christopher. "Multivalent recognition: The place of Hegel in the Fraser–Honneth debate." Contemporary Political Theory 11, no. 1 (July 19, 2011): 23–40. http://dx.doi.org/10.1057/cpt.2010.44.

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Oliver, Samuel S., Catherine A. Musselman, Rajini Srinivasan, John P. Svaren, Tatiana G. Kutateladze, and John M. Denu. "Multivalent Recognition of Histone Tails by the PHD Fingers of CHD5." Biochemistry 51, no. 33 (August 8, 2012): 6534–44. http://dx.doi.org/10.1021/bi3006972.

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Xiao, Shuzhang, Serhan Turkyilmaz, and Bradley D. Smith. "Convenient synthesis of multivalent zinc(II)–dipicolylamine complexes for molecular recognition." Tetrahedron Letters 54, no. 8 (February 2013): 861–64. http://dx.doi.org/10.1016/j.tetlet.2012.11.103.

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Machias, A. V. "Transient stability evaluation by a pattern recognition approach using multivalent logics." Electric Power Systems Research 17, no. 3 (November 1989): 209–17. http://dx.doi.org/10.1016/0378-7796(89)90023-0.

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Olajos, Gábor, Éva Bartus, Ildikó Schuster, Gergely Lautner, Róbert E. Gyurcsányi, Titanilla Szögi, Lívia Fülöp, and Tamás A. Martinek. "Multivalent foldamer-based affinity assay for selective recognition of Aβ oligomers." Analytica Chimica Acta 960 (April 2017): 131–37. http://dx.doi.org/10.1016/j.aca.2017.01.013.

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Olubummo, Adekunle, Matthias Schulz, Regina Schöps, Jörg Kressler, and Wolfgang H. Binder. "Phase Changes in Mixed Lipid/Polymer Membranes by Multivalent Nanoparticle Recognition." Langmuir 30, no. 1 (December 20, 2013): 259–67. http://dx.doi.org/10.1021/la403763v.

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Nady, Nataliya, Alexander Lemak, John R. Walker, George V. Avvakumov, Michael S. Kareta, Mayada Achour, Sheng Xue, et al. "Recognition of Multivalent Histone States Associated with Heterochromatin by UHRF1 Protein." Journal of Biological Chemistry 286, no. 27 (April 13, 2011): 24300–24311. http://dx.doi.org/10.1074/jbc.m111.234104.

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Histone modifications and DNA methylation represent two layers of heritable epigenetic information that regulate eukaryotic chromatin structure and gene activity. UHRF1 is a unique factor that bridges these two layers; it is required for maintenance DNA methylation at hemimethylated CpG sites, which are specifically recognized through its SRA domain and also interacts with histone H3 trimethylated on lysine 9 (H3K9me3) in an unspecified manner. Here we show that UHRF1 contains a tandem Tudor domain (TTD) that recognizes H3 tail peptides with the heterochromatin-associated modification state of trimethylated lysine 9 and unmodified lysine 4 (H3K4me0/K9me3). Solution NMR and crystallographic data reveal the TTD simultaneously recognizes H3K9me3 through a conserved aromatic cage in the first Tudor subdomain and unmodified H3K4 within a groove between the tandem subdomains. The subdomains undergo a conformational adjustment upon peptide binding, distinct from previously reported mechanisms for dual histone mark recognition. Mutant UHRF1 protein deficient for H3K4me0/K9me3 binding shows altered localization to heterochromatic chromocenters and fails to reduce expression of a target gene, p16INK4A, when overexpressed. Our results demonstrate a novel recognition mechanism for the combinatorial readout of histone modification states associated with gene silencing and add to the growing evidence for coordination of, and cross-talk between, the modification states of H3K4 and H3K9 in regulation of gene expression.

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Boal, Andrew K., and Vincent M. Rotello. "Radial Control of Recognition and Redox Processes with Multivalent Nanoparticle Hosts." Journal of the American Chemical Society 124, no. 18 (May 2002): 5019–24. http://dx.doi.org/10.1021/ja016894k.

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