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Books on the topic 'Multipotency'

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Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Harrison, Andrew James. Evidence of multipotency in immortalised cells derived from bone marrow stroma. Manchester: University of Manchester, 1996.

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2

Hoffman, Robert M., ed. Multipotent Stem Cells of the Hair Follicle. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3786-8.

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3

Bamba, Shigeki. Gut stem cells: Multipotent, clonogenic, and the origin of gastrointestinal cancer. New York: Nova Science Publishers, 2008.

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4

Pearson, Mark Andrew. Investigation of molecular mechanisms involved in cytokine synergy in multipotent haemopoietic cells. Manchester: University of Manchester, 1996.

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5

Reynolds, Brent A., and Loic P. Deleyrolle. Neural progenitor cells: Methods and protocols. New York: Humana Press, 2013.

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6

Amit, M., and Joseph Itskovitz-Eldor. Atlas of human pluripotent stem cells: Derivation and culturing. New York: Humana Press, 2012.

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7

Hoffman, Robert M. Multipotent Stem Cells of the Hair Follicle: Methods and Protocols. Springer New York, 2016.

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8

Hoffman, Robert M. Multipotent Stem Cells of the Hair Follicle: Methods and Protocols. Springer New York, 2018.

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9

Reynolds, Brent A., and Loic P. Deleyrolle. Neural Progenitor Cells: Methods and Protocols. Humana Press, 2016.

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10

Deleyrolle, Loic P. Neural Progenitor Cells: Methods and Protocols. Springer, 2021.

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11

Deleyrolle, Loic P. Neural Progenitor Cells: Methods and Protocols. Springer, 2022.

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12

Fulcoli, F. Gabriella, and Antonio Baldini. Transcriptional regulation of early cardiovascular development. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, José Luis de la Pompa, David Sedmera, Cristina Basso, and Deborah Henderson. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0006.

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The two major cardiac cell lineages of the vertebrate heart, the first and second cardiac fields (FHF and SHF), have different developmental ontogeny and thus different transcription programs. Most remarkably, the fate of cardiac progenitors (CPs) of the FHF is restricted to cardiomyocyte differentiation. In contrast, SHF CPs, which are specified independently, are maintained in a multipotent state for a relatively longer developmental time and can differentiate into multiple cell types. The identity of the transcription factors and regulatory elements involved in progenitor cell programming and fate are only now beginning to emerge. Apparent inconsistencies between studies based on tissue culture and in vivo embryonic studies confirm that the ontogeny of cardiac progenitors is strongly driven or affected by regionalization, and thus by the signals that they receive in different regions. This chapter summarizes current knowledge about transcription factors and mechanisms driving CP ontogeny, with special focus on SHF development.

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13

Induced Pluripotent Stem Cells Springerbriefs in Stem Cells. Springer, 2011.

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14

Itskovitz-Eldor, Joseph, and Michal Amit. Atlas of Human Pluripotent Stem Cells: Derivation and Culturing. Humana, 2016.

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15

Itskovitz-Eldor, Joseph, and Michal Amit. Atlas of Human Pluripotent Stem Cells: Derivation and Culturing. Springer, 2011.

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16

Mesenchymal Stem Cell Therapy Stem Cell Biology and Regenerative Medicine. Humana Press, 2012.

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17

Tyndall, Alan, and Jacob M. van Laar. Stem cell therapies. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199642489.003.0085.

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Since the start of the international project in 1997, over 1500 patients have received a haematopoietic stem cell transplant (HSCT), mostly autologous, as treatment for a severe autoimmune disease, with overall 85% 5-year survival and 43% progression-free survival. Around 30% of patients in all disease subgroups had a complete response, often durable despite full immune reconstitution. In many cases, e.g. systemic sclerosis, morphological improvement such as reduction of skin collagen and normalization of microvasculature was documented, beyond any predicted known effects of intense immunosuppression alone. It is hoped that the results of the three running large prospective randomized controlled trials will allow modification of the protocols to reduce the high transplant-related mortality which relates to regimen intensity, age of patient, and comorbidity. Multipotent mesenchymal stromal cells (MSC) have been recently tested in various autoimmune diseases, exploiting their immune modulating properties and apparent low acute toxicity. MSC display immune privilege in that the patient requires no immunosuppression prior to allogeneic MSC infusion. Despite encouraging small phase I/II studies, no positive data from randomized prospective studies are as yet available in the peer-reviewed literature.

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18

Tyndall, Alan, and Jacob M. van Laar. Stem cell therapies. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199642489.003.0085_update_003.

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Since the start of the international project in 1997, over 2000 patients have received a haematopoietic stem cell transplant (HSCT), mostly autologous, as treatment for a severe autoimmune disease, with overall 85% 5-year survival and 43% progression-free survival. Around 30% of patients in all disease subgroups had a complete response, often durable despite full immune reconstitution. In many cases, e.g. systemic sclerosis, morphological improvement such as reduction of skin collagen and normalization of microvasculature was documented, beyond any predicted known effects of intense immunosuppression alone. It is hoped that the results of the three running large prospective randomized controlled trials will allow modification of the protocols to reduce the high transplant-related mortality which relates to regimen intensity, age of patient, and comorbidity. Multipotent mesenchymal stromal cells (MSC) have been recently tested in various autoimmune diseases, exploiting their immune modulating properties and apparent low acute toxicity. MSC display immune privilege in that the patient requires no immunosuppression prior to allogeneic MSC infusion. Despite encouraging many small phase I/II studies, only 2 prospective controlled trials which achieved their primary endpoints have been published.

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19

J, Prockop Darwin, Phinney Donald G, and Bunnell Bruce A, eds. Mesenchymal stem cells: Methods and protocols. Totowa, NJ: Humana Press, 2008.

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20

Bunnell, Bruce A., Darwin J. Prockop, and Donald G. Phinney. Mesenchymal Stem Cells: Methods and Protocols. Humana Press, 2010.

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21

(Editor), Darwin J. Prockop, Donald G. Phinney (Editor), and Bruce A. Bunnell (Editor), eds. Mesenchymal Stem Cells: Methods and Protocols (Methods in Molecular Biology). Humana Press, 2008.

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