Relevant bibliographies by topics / Multiple sclerosis

Academic literature on the topic 'Multiple sclerosis'

Author: Grafiati
Published: 4 June 2021
Last updated: 29 July 2024

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Journal articles on the topic "Multiple sclerosis"

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KAMALAK, HAKAN, and HICHAM NUAIMI. "MULTİPLE SCLEROSİS AND AMALGAM." Asian Pacific Journal of Health Sciences 1, no. 3 (July 2014): 146–48. http://dx.doi.org/10.21276/apjhs.2014.1.3.3.

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Artur Medina, Jose. "Multiple Sclerosis and Chlamydia." International Journal of Clinical Case Reports and Reviews 9, no. 1 (November 30, 2021): 01–02. http://dx.doi.org/10.31579/2690-4861/163.

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Although the epidemiological similarity between the two diseases is true, this thesis was not discussed extensively, perhaps because it implied that some children might have been victims of abuse, which sounds false and potentially unfair. We believe that transverse myelitis and MS are the result of an infectious disease, eventually sexually transmitted by chlamydia/gonococcus, which is caused by a subclinical bacterial urethritis/inflamatory pelvic disease (IPD) among adults. In children it is the same disease but caused by common uropathogens/enterobacteria. Both UTI and MS are much more common in girls than in boys [2, 3]. These UTIs would favor herpetic proliferation via toll-like receptors (TLRs), since the virus is endemic and always present, and it is not possible to eradicate it completely. Herpes viral load is counteracted by interferon alpha 1 (IFN alpha-1), present in different cell types, from macrophages to lymphocytes passing through endothelia and fibroblasts. Interferon alpha 1, when interacting with its specific receptors, produces in the intracellular the action of antiviral RNAse and the inhibition of viral protein synthesis
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Shepeleva, A. D., D. F. Shamardanov, and E. V. Ponomarenko. "PATHOPHYSIOLOGY OF MULTIPLE SCLEROSIS." European Journal of Natural History, no. 4 2022 (2022): 12–16. http://dx.doi.org/10.17513/ejnh.34281.

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ÖZTÜRK, Serra, Güneş AYTAÇ, Ferah KIZILAY, and Muzaffer SİNDEL. "Multiple Sclerosis." Akdeniz Medical Journal 3, no. 3 (September 28, 2017): 137–47. http://dx.doi.org/10.17954/amj.2017.86.

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Marenčák, Jozef. "Multiple sclerosis and male infertility." Urologie pro praxi 19, no. 4 (October 1, 2018): 181–84. http://dx.doi.org/10.36290/uro.2018.083.

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Medina, Jose Artur. "Multiple Sclerosis, Chlamydia and Gut Disbiosis." Journal of Clinical Research and Reports 9, no. 3 (November 20, 2021): 01–02. http://dx.doi.org/10.31579/2690-1919/208.

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I believe that multiple sclerosis progression could be stopped through antibiotics, dewormers, beta glucans and garlic extract and, by far the most difficult, changing the quality of the water ingested, or used for washing salads, in addition to increasing the consumption of probiotics. I believe that MS sclerosis is due to the unfortunate encounter of 3 diseases: intestinal dysbiosis, chlamydia infections and orthopedic problems. However, how would these three diseases cause demyelination of nerve fibers?
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Yamada, Shoko M., So Yamada, Hiroshi Nakaguchi, Mineko Murakami, Katsumi Hoya, Akira Matsuno, Kazuto Yamazaki, and Yasuo Ishida. "A Case of Tumefactive Multiple Sclerosis." Japanese Journal of Neurosurgery 21, no. 5 (2012): 427–32. http://dx.doi.org/10.7887/jcns.21.427.

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Kantorová, Ema. "Significance of multiple sclerosis early treatment." Neurologie pro praxi 20, no. 4 (September 1, 2019): 288–90. http://dx.doi.org/10.36290/neu.2019.155.

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La Mantia, L. "Neurodegenerazione, neuroprotezione e sclerosi multipla [Neurodegeneration, neuroprotection and multiple sclerosis]." Neurological Sciences 27, no. 4 (September 2006): 293. http://dx.doi.org/10.1007/s10072-006-0689-5.

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Antonis, Theofilidis. "Investigating memory storage difficulties in Multiple Sclerosis." Neuroscience and Neurological Surgery 9, no. 5 (November 24, 2021): 01–07. http://dx.doi.org/10.31579/2578-8868/185.

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Μemory by itself as a function, loses its capabilities with a normal deterioration. However, there are acquired conditions that negatively affect the functions of memory, resulting in dysfunction of its stages. Thus possible damage to the structures of the hemisphere that controls these processes disrupts the comprehension, organization and categorization of the material to be memorized. Patients with damage to these systems will have difficulty remembering because they have not adequately coded the material. Patients with Multiple Sclerosis report short-term memory difficulties in the sense that they have difficulty remembering details of recent conversations and events. Aim: To investigate the memory storage difficulties in Multiple Sclerosis. Materials and Methods: An international literature review was performed on Memory Disorders in Multiple Sclerosis. Conclusion: In patients with Multiple Sclerosis learning deficits are greatly aided by processing speed and working memory. It has been observed that slow mental processing makes it difficult for many patients with Multiple Sclerosis to capture an entire verbal message, especially if it is large, complex, delivered quickly and with external stimuli, such as a noisy environment
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Dissertations / Theses on the topic "Multiple sclerosis"

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Littleton, Edward Theodore. "Autoantibodies in Multiple Sclerosis." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491344.

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rvIultiple sclerosis (MS) is an inflammatory disease of the central nervous system, characterised by axonal demyelination and degeneration. Hypothesised as autoimmune, antibodies to neuronal and myelin proteins have been reported, but there is little evidence of pathogenic antibodies against cell membrane targets. The aim of this thesis was to investigate whether MS patient sera contain antibodies against neuronal or oligodendroglial cells, and to develop techniques by which protein antigenic targets on cell membranes could be identified. Forty-one MS sera were tested for IgG binding to rat brain. Antibody binding to whlte matter was more frequent amongst relapsing-remitting MS patients compared to healthy controls, but western immunoblotting of myelin and rat brain extracts failed to demonstrate any specific reactivity of MS sera. One hundred MS sera were tested by immunofluorescence for IgG or IgM binding to the cell surface of neuroblastoma and oligodendroglioma cells. The number of sera containing cell-binding antibodies was not significantly greater amongst MS patients than amongst healthy controls. Using muscle specific tyrosine kinase (MuSK) seropositive myasthenia gravis as an experimental paradigm, an immunoprecipitation technique to isolate cell surface antigenic targets of serum antibodies, employing cell surface biotin labelling, was developed. Immunoprecipitated proteins were visualised with great sensitivity after gel electrophoresis and blotting. Two MS sera were found 'which specifically immunoprecipitated certain proteins, but development of an unbiased mass spectrometry technique for identifying immunoprecipitated proteins proved difficult due to immunoprecipitate impurity. Eventually, a new protocol for immunoprecipitate digestion and purification prior to mass spectrometry allowed reliable identification of MuSK exclusively in immunoprecipitates derived from MuSK seropositive patients. Thus, a clinically relevant cell membrane antigen has been identi?ed using a novel, non-candidate, unbiased proteomic approach. The same versatile techruque could be applied to identify proteins in immunoprecipitates derived from patients with MS or other putative antibody-mediated diseases. II Supplied by The British Library - 'The world's knowledge' I II. 11 has been observed on carbon nanotubes than graphite. The adsorption isotherms follow Langmuir isotherm except cytosine. Mathematical adsorption models devised here reveal that adenine binding onto graphite could be explained by the interaction between neutral base molecules and neutral surfaces. The adsorption is suggested to be goyemed by three factors: solubility, basestacking and the 1t-1t electron interactions. The adsorption onto quartz, gibbsite and feldspar show little or no adsorption but adsorption onto 'halloysite' is strong with the molecules containing cytosine or adenine groups, especially cytosine groups. Nucleotides adsorb the most followed by bases and nucleosides in this case. pH dependence of cytosine adsorption onto halloysite has been analysed by mathematical adsorption models as well, which shows that the whole adsorption constituents two types of adsorption. Type I can be ascribed to the binding between =SiO- and protonated cytosine, or the binding between =SiOH and neutral cytosine independently. Type 2 can be designated to the binding between =SiO- and neutral cytosine. Mathematical model analysis of literature data illustrates that the adsorption ofbases/nucleosides onto montmorillonite could be described by two types of bindings independently: =AIOH groups bind protonated bases/nucleosides, and =AIOH2+ groups bind neutral bases/nucleosides.- Graphite could prefer to concentrate nucleosides while halloysite could favour nucleotides accumulation. Carbon nanotubes and halloysite, which are both tubular, could have facilitated biomolecules adsorption from diluted primitive oceans. Although no new ideas have been discovered in the process of origins of life, the adsorption difference onto different minerals have shown the importance of minerals in concentrating, selecdng and possible protecting and storing prebiotic biomolecules.
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Bloem, Liezl. "Iron and multiple sclerosis." Thesis, Link to the online version, 2007. http://hdl.handle.net/10019/340.

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Kaiser, Cora. "Autoantibodies in Multiple Sclerosis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-171441.

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Rigby, Sally. "Coping with multiple sclerosis." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288858.

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Claffey, Austin M. "Metamemory in multiple sclerosis." Thesis, Brunel University, 2010. http://bura.brunel.ac.uk/handle/2438/4513.

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The concept of metamemory proposes that supplementary to typically measured memory abilities, memory monitoring and control processes are used to optimise learning. Accurate memory monitoring appears to be underpinned by a range of cognitive, and possibly affective, contributions. In populations with these deficits, metamemory has been shown to be impaired. In Multiple Sclerosis (MS), only a limited metamemory literature exists, surprising given that MS is a leading cause of disability among people of working age, and cognitive and mood disorder is common. Using structural equation modelling, this study of 100 people with MS explored factors contributing to performance on episodic Judgment of Learning, Retrospective Confidence and Feeling of Knowing. Given its negative influence on cognitive domains in MS, the impact of information processing deficits on metamemory was also investigated. Finally, memory self-report, a frequently used clinical indicator of memory functioning, was assessed. Findings suggest that memory complaint is associated with mood, and is unrelated to tested memory. Second, Retrospective Confidence Judgments were predictive of memory performance, even in the presence of memory impairment. Third, an unusual finding of maintained underconfidence at delay was observed in the Judgment of Learning task. Finally, Feeling of Knowing judgments related to executive, but not to memory ability. A novel finding in respect of this judgment was of processing speed relating negatively to accuracy, in the context of executive dysfunction. This suggests that some top-down direction of processing resources may be a factor in supporting accuracy, rather than the speed at which information is processed. Of all the task-based judgments, accuracy in this judgment was the only one with a reliable association with mood. Faster processing speed, executive dysfunction and least depression symptomatology related to low accuracy, perhaps typifying a profile of disinhibition seen in MS, characterised by poorly constrained processing and apparently elevated mood.
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Connolly, Gayle Wood. "Pain in multiple sclerosis." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/5115/.

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Multiple Sclerosis (MS) is a chronic, progressive disease which presents as a variety of cognitive, motor and sensory deficits (Compston and Coles, 2008). Pain is one of the most common and often severe symptoms of the disease. It is associated with poorer general health, and its management is therefore an important therapeutic target. People with MS can suffer from neuropathic pain as a direct result of damage to the central nervous system, or nociceptive pain, as a result of changes to the musculoskeletal system, secondary to disease progression. This was the first epidemiological study to measure the prevalence, characteristics, and impact of MS-related pain, using validated, IMMPACT-recommended measures. Neuropathic pain, common in MS, is a challenge to manage and is shown to impact on a person health-related quality of life (HR-QOL). Subsequently, the second part of this study explored the impact of Transcutaneous Electrical Nerve Stimulation (TENS) on neuropathic pain in MS, in a randomised controlled trial. A postal survey design was used to target the MS population of the NHS Ayrshire and Arran health board area, who completed a questionnaire on their pain experience (n=302). Clinically significant pain, defined as ongoing bothersome pain, was experienced by over two-thirds (71.5%), whilst chronic pain, defined as pain present for at least six months, was experienced by over half (59.2%) of the MS population. Neuropathic pain, assessed using the PainDETECT screening tool, was experienced by almost one third (32.7%) of the sample, with a further 14.7% identified as potentially having neuropathic pain. Thus 47.4% of the sample could potentially have neuropathic pain, which is higher than previous estimates, and that experienced by the general population. Approximately half the population experienced painful tonic spasms (44.5%) and dysaesthetic pain (56.2%). Burning pain, unpleasant paraesthetic sensations (i.e. crawling, tingling), and sharp pain were commonly experienced in the population with neuropathic pain. Multiple logistic regression analysis revealed Type of MS (p=0.001) and disability level (Guys Neurological Disability Scale (GNDS) (p<0.001) as independent predictors of neuropathic pain, possibly related to the pathophysiology of the disease. Neuropathic pain was shown as statistically more severe (using the 11-point Numerical Rating Scale of pain intensity (NRS-11) (p<0.001), more emotionally unpleasant (using the SF-MPQ) (p<0.001), with greater sleep disturbance (p<0.001), than nociceptive pain. Despite over two-thirds (68.5%) of those with neuropathic pain currently using prescribed, pain-relieving medication, over half (53.7%) still experienced severe (7-10 on NRS-11) pain. The presence of neuropathic also had a significantly negative impact on HR-QOL (EQ-5D) (p<0.001). The results of the epidemiological study increase understanding of the extent and demanding nature of pain in MS. Clinically, it will also facilitate timely screening for the neuropathic pain subtype, to minimise its impact on HR-QOL. Following the epidemiological findings, a randomised, double-blind, placebo-controlled trial, explored the efficacy of Transcutaneous Electrical Nerve Stimulation (TENS) in the treatment of chronic, neuropathic pain in MS (n=46). Participants were recruited from the MS Service, NHS Ayrshire and Arran, with a diagnosis of lower limb neuropathic pain (score of ≥19 on the PainDETECT Screening tool for neuropathic pain), experienced for a minimum of six months. For the active TENS group, standard ‘Conventional’ TENS settings were applied, whilst a low frequency, low intensity, long pulse duration electrical current was used for the placebo application, which has no known analgesic effect, but still provides a sensory stimulus. Both groups used the TENS machine for a minimum of four hours/day, for a two-week period. Two long self-adhesive, hypo-allergenic electrodes were placed paravertebrally over the lumbar spine to stimulate the spinal nerve roots. The primary outcome measure was the (NRS-11), whilst secondary outcome measures included the Neuropathic Pain Scale (NPS), and the Patients Global Impression of Change (PGIC). Level of pain related interference on function was measured using the Brief Pain Inventory (BPI). Compared to the control group, the group receiving active TENS demonstrated a statistically (p<0.001) and clinically significant reduction in the intensity of neuropathic pain over the two-week intervention period. It was particularly effective for the burning, and sharp neuropathic pain qualities, that were commonly associated with neuropathic pain in the epidemiological study. TENS was also shown to reduce the emotional unpleasantness of pain (the affective component), which was high in those with neuropathic pain in the epidemiological study. This may have implications for the role of TENS in managing the psychological aspect of chronic neuropathic pain. TENS has no effect on pain–related interference on function, possibly due to the relatively short TENS intervention period. Future studies should explore longer intervention periods to explore the longer-term effects of TENS for pain in MS. The pharmacological management of neuropathic pain is not without its challenges. TENS as an inexpensive, non-invasive modality, with no side-effects, could be considered for the management of neuropathic pain, a common phenomenon in the MS population.
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O'Gorman, Cullen. "Epidemiology of Multiple Sclerosis." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/374775.

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Multiple sclerosis (MS) is a chronic disabling disease of the central nervous system commonly affecting young adults. Pathologically, there are patches of inflammation (plaques) with demyelination of axons and associated loss of oligodendrocytes. Genome-wide association studies have identified over 105 loci of susceptibility, but the total number of possible contributory loci may be considerably higher. Family recurrence risks are available for several northern hemisphere countries, but there are few data for the southern hemisphere and regions at lower latitude such as Australia. The published family data could provide useful recurrence risks if appropriately analysed. Segregation analysis can be used to model the genetic architecture of MS. There is a global latitude gradient in MS prevalence, and the incidence of MS is increasing (particularly in females). These changes suggest a major role for environmental factors in the causation of disease. In the last 20 years there has been increasing evidence for the role of smoking in the aetiology of multiple sclerosis. Cigarette smoking is also associated with increased risk of developing the progressive form of MS. This risk factor has not previously been analysed in Queensland. Furthermore, cigarette smoking represents a possible cause of the changing prevalence of MS over time. Methods The family risks in Australia were measured in three regions at different latitudes. Immediate and extended family pedigrees were collected for three cohorts of MS patients in Queensland, Victoria and Tasmania. Age of onset data from Queensland were utilised to estimate age-adjusted recurrence rates. Meta-analysis of all available family recurrence risk data was performed to define risks to relatives. Standard methods of meta-analysis were combined with novel approaches to age adjustment to provide directly comparable estimates of lifetime risk. Segregation analysis was used to estimate the proportion of the overall genetic risk that can be attributed to identified susceptibility genes. To evaluate risks from smoking in Queensland, a large case-control study was performed, comparing risk of MS (by smoking habit) using regression modelling. The risk of developing progressive disease was measured in a cohort from an MS clinic in Queensland, followed from first clinic attendance until the onset of clinically determined progressive disease. Risk of progression was analysed with gender, age, age of onset, exposure to disease modifying therapy, and smoking status as covariates in a Cox proportional hazards analysis. Finally, a comprehensive meta-analysis was performed of eligible casecontrol and cohort studies that evaluated the risk of MS in smokers and exsmokers. The influence of study design, gender, latitude and year of study were explored with regression modelling. Results Recurrence risks in Australia were significantly lower than in studies from northern hemisphere populations. The age-adjusted risk for siblings across Australia was 2.1% compared with 3.5% for the northern hemisphere. A similar pattern was seen for other relatives. The risks to relatives were proportional to the population risks for each site, and hence the relative risk for siblings (lS) was similar across all sites. From the meta-analysis of family recurrence risks, the overall recurrence risk for monozygotic twins was 18.2% and for siblings 2.7%. The recurrence risk for dizygotic twins was significantly higher than for siblings. The overall estimate of sibling relative risk (lS) was 16.8. Risks for older relatives (parents, siblings, aunts, uncles and cousins) show a latitudinal gradient, in line with population risk. No latitudinal gradient for lS was seen. Segregation analysis supports a multiplicative model of one locus of moderate effect with many loci of small effect. The estimated contribution of the known MS loci is 18–24% of lS. The case-control study in Queensland confirmed an association between increased risk of MS and smoking. The overall adjusted odds ratio was 1.9 (95% confidence interval, CI 1.5–2.5) for ever smokers. There was no statistically significant difference in the risks for males and females. In the progression study, there were significantly higher risks of secondary progressive disease in males (Hazard Ratio, HR 1.83, 95% CI 1.3–2.7) and in ever smokers (HR 1.4, 95% CI 1.0–2.0). Progressive disease occurred approximately 4 years earlier in ever smokers. Smoking did not affect age of onset of primary progressive disease. The meta-analysis of smoking risk included 26 studies representing 8615 cases and 392,352 controls and an additional 792 cases included from a total cohort population of 601,492 individuals, representing more than 9 million person-years. There was a consistent association between smoking and MS with an odds ratio of approximately 1.5, with males at higher risk. This finding was independent of study design. However, latitude and year of study may have unexpected influence. Smoking appeared to confer a greater risk to females living closer to the equator than to females at higher latitudes. Additionally, the effect of cigarette smoke exposure on MS risk may not be fixed over time, but could be increasing. Discussion The familial recurrence risk of MS in Australia is lower than in previously reported studies. This is directly related to the lower population prevalence of MS. The overall genetic susceptibility in Australia as measured by the lS is similar to that seen in the northern hemisphere, suggesting that the difference in population risk is explained largely by environmental factors rather than by genetic admixture. The meta-analysis of family data supports the notion of MS risk being derived from multiple susceptibility genes and environmental factors. Genetic susceptibility appears to be independent of latitude, and the latitudinal gradient of MS prevalence is likely due to environmental factors. The results of the case-control study in Queensland replicate existing work that has shown cigarette smoking increases the risk of MS. Cigarette smoking represents an important modifiable risk factor for the development of MS. Cigarette smoking was also associated with earlier onset of progressive disease in the large clinical cohort studied in Queensland. For patients with relapsing-remitting disease, smoking cessation should be encouraged. The results of the meta-analysis of smoking studies suggest a threshold model of MS risk that includes a fairly constant genetic risk (for Caucasian populations) together with variable environmental risks which are dominated by vitamin D deficiency at higher latitudes and are more significant in women who have an intrinsically lower threshold for development of disease.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medicine
Griffith Health
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Foley, Peter Leonard. "Pain in multiple sclerosis." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28949.

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Background: Pain is frequently reported by people with multiple sclerosis (MS). It has been associated with decreased quality of life, psychiatric morbidity, interference with day to day activities, and frequent healthcare attendance. It has been reported by people with multiple sclerosis to be one of their most important symptoms, and available treatments are limited in their effectiveness. Despite this, our understanding of the epidemiology and mechanisms of pain in people with MS are limited. Our understanding of the interactions of central nervous system mechanisms and pain states overall is growing. However, the application of this knowledge to MS is incomplete. Previous studies have shown that the descending pain modulatory system (DPMS) is an endogenous network of cortical and subcortical brain structures which act to limit, or accentuate, an individual’s perception of pain, via descending brainstem pathways. Associated clinical measures include depression, anxiety, and cognitive flexibility. Our understanding of the function or dysfunction of this system in MS is limited. We do not know if the MS disease process may adversely affect the structure or function of the DPMS. Hypothesis: In people with neuropathic limb pain in relapsing remitting MS (RRMS), compared to people with RRMS who do not have pain, there will be disruption of the endogenous descending pain modulatory system. This will manifest as impaired descending inhibition of pain. Aims and Methods Establishing the background using systematic reviews: The first aim of this thesis was to establish the prevalence, natural history and associations of pain (and pain syndromes) occurring in people with MS. The second aim was to explore existing knowledge of how the MS disease process may contribute to pain states, using a systematic review of neuroimaging studies. Prospective clinical study: A case-control study of 47 people with RRMS was then carried out. 31 of these had neuropathic pain in the limbs, and 16 did not have pain. Using targeted assessments, function of the descending pain modulatory system was assessed in the following ways: First: Detailed clinical, behavioural and neuropsychological assessment, focussing on cognitive, behavioural and affective features known to be closely related to the DPMS. Second: MRI imaging of brain structure, focussing on the volume and location of MS lesions, as well as the volume of key grey-matter structures involved in the DPMS. Third: Resting state functional MRI imaging of the brain, focussing on functional connectivity between the rostral anterior cingulate cortex and two other key DPMS structures (dorsolateral prefrontal cortex, and periaqueductal gray). Results: Systematic reviews: Meta-analysis of existing prospective studies confirmed that pain is very common in MS, affecting about 63% of people with MS on average (95%CI between 55 and 70%). Many different types of pain contribute to this overall estimate. No significant associations with disease course or stage emerged. Several neuroimaging studies have assessed people with MS-associated pain using MRI. These studies were often small, and with associated methodological issues. It is likely that location of MS lesions is implicated in aetiology of pain syndromes in some cases, though our overall knowledge is limited. Prospective study: In a prospective study, people with and without pain were matched for age and gender. Furthermore, groups were balanced for a range of other variables. The pain group more frequently received gabapentinoid medications. The presence of pain was significantly associated with increased scores for depression, fatigue and catastrophising, as well as with specific impairments at neuropsychological assessment, including cognitive flexibility. Many of these impairments are directly relevant to existing models of the DPMS. Overall volume of MS lesions was not different in people with pain, though lesions were more likely to occur in the brainstem. Some alterations of grey-matter volumes in people with pain which mirrored studies of pain disorders outside MS were found, but these did not involve structures key to the DPMS. Affected structures included trigeminothalamic nucleus (relative volume increase in pain group), posterior cingulate cortex and parahippocampal gyrus (volume decrease in pain group). Functional connectivity of the rostral anterior cingulate cortex to the periaqueductal grey matter, a key structure in the descending modulation of pain, was stronger in the group without pain. Conversely, functional connectivity to the dorsolateral prefrontal cortex, repeatedly implicated in the DPMS and thought to be involved in cognitive evaluation and flexibility, was stronger in the pain group. MS lesion volume appeared to account for some of this difference in a multivariate analysis. Limitations: Key limitations of this work include cross-sectional design, small sample size, and number of statistical comparisons carried out. Conclusions: Systematic reviews examined the prevalence, natural history and associations of pain in MS, as well as examining existing neuroimaging studies which investigated how the MS disease process could contribute to pain states. A prospective study found evidence of both emotional/affective and cognitive dysfunctions relevant to the hypothesis of dysfunction in the DPMS. Higher likelihood of MS lesions in the brainstem could be relevant to DPMS function. Separately, there were structural grey-matter volume alterations reflecting those found in many pain studies outside MS. Importantly, however, these did not affect key DPMS structures. Resting state functional MRI however demonstrated altered connectivity of core DPMS structures, which may be partly mediated by MS lesion volume. Functional connectivity findings could be consistent with the hypothesis of impaired descending pain inhibition, in people with relapsing remitting MS affected by neuropathic limb pain.
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Ligers, Arturs. "Immunogenetic studies of multiple sclerosis /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-019-9/.

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Lu, Ellen Meng-I. "Perinatal outcomes in multiple sclerosis." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44199.

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Books on the topic "Multiple sclerosis"

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Jürg, Kesselring, ed. Multiple sclerosis. Cambridge: Cambridge University Press, 1997.

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Kalb, Rosalind C. Multiple Sclerosis. New York: Demos Medical Publishing, 2009.

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Olek, Michael J., ed. Multiple Sclerosis. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1592598552.

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JÜRG, ERNST W, and KENNETH. MULTIPLE SCLEROSIS. Edited by LUDWIG. Abingdon, UK: Taylor & Francis, 1988. http://dx.doi.org/10.4324/9780203212974.

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Abramovitz, Melissa. Multiple sclerosis. Detroit: Lucent Books, 2010.

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Weissert, Robert, ed. Multiple Sclerosis. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-2630-5.

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Kesselring, Jurg, Giancarlo Comi, and Alan J. Thompson, eds. Multiple Sclerosis. Cambridge: Cambridge University Press, 2009. http://dx.doi.org/10.1017/cbo9780511781698.

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Weiner, Howard L., and James M. Stankiewicz, eds. Multiple Sclerosis. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781119963714.

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De Souza, Lorraine H. Multiple Sclerosis. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8.

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Goodkin, Donald E., and Richard A. Rudick, eds. Multiple Sclerosis. London: Springer London, 1996. http://dx.doi.org/10.1007/978-1-4471-1271-6.

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Book chapters on the topic "Multiple sclerosis"

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Tselis, Alex C., and Omar A. Khan. "Multiple Sclerosis." In Multiple Sclerosis, 131–43. Totowa, NJ: Humana Press, 2005. http://dx.doi.org/10.1385/1-59259-855-2:131.

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Robinson, Ian. "Managing multiple sclerosis: A partnership between professional practitioners and patients." In Multiple Sclerosis, 1–15. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_1.

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Monks, Judith. "Personal and social meanings of multiple sclerosis." In Multiple Sclerosis, 140–52. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_10.

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Robinson, Ian, Rosemary Jones, and Julia Segal. "Patients, their families and multiple sclerosis." In Multiple Sclerosis, 153–74. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_11.

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Worthington, Jennifer. "When has therapy succeeded, and for whom?" In Multiple Sclerosis, 175–88. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_12.

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Lange, Leo S. "Multiple sclerosis: Neurology." In Multiple Sclerosis, 16–23. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_2.

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De Souza, Lorraine H. "A therapeutic approach to management." In Multiple Sclerosis, 24–33. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_3.

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De Souza, Lorraine H. "Physiotherapy." In Multiple Sclerosis, 34–53. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_4.

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De Souza, Lorraine H. "Occupational therapy." In Multiple Sclerosis, 54–71. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_5.

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Enderby, Pamela. "Communication disorders." In Multiple Sclerosis, 72–87. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4899-3107-8_6.

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Conference papers on the topic "Multiple sclerosis"

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Guerrera, Brittany, Samantha Farrow, Gloria Zeng, and Sally F. Shady. "Multiple Sclerosis Symptom Analyzer." In ASME 2016 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/imece2016-66217.

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Multiple Sclerosis (MS) is a chronic neurodegenerative disease of the central nervous system. MS is typically diagnosed between the ages of 20 and 40. There is no known cause of the disease and each individual experiences varying signs and symptoms depending on the severity of their disease. The most common symptoms include tremor, debilitated gait, visual impairment, or cognitive and emotional disturbances. Current methods used to treat MS include oral medication and surgical treatment. The issues with oral medication are the unwanted side effects to otherwise healthy tissue and the lack of patient adherence. Surgical treatment can be invasive and require longer recovery times. An alternate strategy to treat MS is by increasing the knowledge base of the practitioner to potentially treat specific symptoms. Currently, physicians use observations and MRI scans of the brain and spinal cord to help diagnose and track the progression of MS. There are several studies that analyze existing assistive technology to aid in the treatment of MS tremors. Most of these studies did not involve large test groups, therefore it is difficult to prove their validity. Additionally, none of the current devices are able to track symptoms while simultaneously creating medical history records. The goal of the design is to create a new device that will obtain the frequency and amplitude of tremors, while analyzing the effects of temperature and heart rate on the intensity of the tremor. With this data, the device will advance further MS research and lead to better diagnosis and treatment.
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Teodoru, Gigi. "Multiple Sclerosis – A Physiotherapeutic Challenge." In ICPESK 2018 - International Congress of Physical Education, Sports and Kinetotherapy. Education and Sports Science in the 21st Century, Edition dedicated to the 95th anniversary of UNEFS. Cognitive-Crcs, 2019. http://dx.doi.org/10.15405/epsbs.2019.02.65.

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de Almeida, Roberta Diniz, José Albino da Paz, Renata Barbosa Paolilo, Clarice Semião Coimbra, Rafaela Fernandes Dantas, Nicholas dos Santos Barros, Ana Cristina Azevedo Leão, Daniel Shoji Hayashi, and Joemir Jabson da Conceição Brito. "Tourettism secondary to multiple sclerosis." In SBN Conference 2022. Thieme Revinter Publicações Ltda., 2023. http://dx.doi.org/10.1055/s-0043-1774620.

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MacKay, Alex L., Cornelia Laule, Burkhard Mädler, Alexander Rauscher, Irene Vavasour, Gerardo Herrera Corral, and Luis Manuel Montaño Zentina. "Studying Multiple Sclerosis with Magnetic Resonance." In MEDICAL PHYSICS: Tenth Mexican Symposium on Medical Physics. AIP, 2008. http://dx.doi.org/10.1063/1.2979305.

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Pinhati, Clara Catharino, Pedro L. Bessa dos Reis, Ana Cristina Cotta Queiroz, Beatriz Silva Lombardi, Cleison Sanches Silva, Gabriel Coelho, Denison Pedrosa, et al. "Trastuzumab-Induced Demyelination Simulating Multiple Sclerosis." In PROCEEDINGS OF THE BCTRIMS 24TH ANNUAL MEETING. Galoa, 2023. http://dx.doi.org/10.17648/bctrims-2023-167489.

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FERNANDES, IVONE REGINA, Maria Fernanda Mendes, and Antonio REGINA Yasbek. "Experience with telemedicine in Multiple Sclerosis." In PROCEEDINGS OF THE BCTRIMS 24TH ANNUAL MEETING. Galoa, 2023. http://dx.doi.org/10.17648/bctrims-2023-167437.

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Silva, Diógenes Emanuel Dantas da, Leandro Cabral Moreira Guimarães, Maria Eduarda Medeiros Martins, Tereza Cristina Batista Dias, Brendo Bezerra Bevenuto, Daniel Vicente de Siqueira Lima Junior, Luíza Alves Monteiro Torreão Villarim, and Bianca Etelvina Santos Oliveira. "Clinical aspects of multiple sclerosis in childhood." In XIV Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2023. http://dx.doi.org/10.5327/1516-3180.141s1.642.

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Introduction: Multiple sclerosis (MS) is an autoimmune, demyelinating, and inflammatory disease affecting the central nervous system. This condition has an unknown etiology and variable prevalence, being more common in young adult females. The prevalence of MS in childhood is low, ranging from 2% to 4% of all cases. Objectives: This study aims to describe the clinical development and symptoms of MS in children, contrasting them with the development of MS in adults. Dessign: This is an integrative literature review. Methods: Ten articles were selected from the PubMed and SciELO in English and Portuguese between 2010 and 2020. The keywords used were Multiple Sclerosis and Pediatric. Results: The prevalence of MS in children presenting with clinical symptoms is estimated to be between 2% and 5% of all MS cases. Despite variations in prevalence, the relapsing-remitting subtype and female predominance are similar to MS in adults. The female-to-male ratio ranges from 1.13:1 to 3.88:1. The relapsing-remitting subtype accounted for 85.7% to 100% of cases. While there is no typical presentation of clinical symptoms, optic neuritis, motor alterations, sensory changes, and cerebellum and brain stem dysfunctions are frequently reported. Unlike what is observed in adults, MS in children typically presents in a more diverse range of ways and progresses more rapidly and severely, with multifocal presentations. Also, children experience slower illness progression due to higher neuroplasticity but reach the impairment milestone before adults. Conclusion: The clinical presentation of multiple sclerosis in childhood is diverse, presenting different characteristics of adults. There is no consensus on the most prevalent symptoms. However, there are similarities in gender and subtype between children and adults with the disease.
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Farias, Fabiano Ricardo, Pedro Costa Klein, Ricardo Bernardi Soder, Jefferson Becker, and Marcio Sarroglia Pinho. "MRI Interpolation for Multiple Sclerosis Lesion Quantification." In 2016 IEEE 40th Annual Computer Software and Applications Conference (COMPSAC). IEEE, 2016. http://dx.doi.org/10.1109/compsac.2016.159.

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Ho, Joyce C., Joydeep Ghosh, and K. P. Unnikrishnan. "Risk Prediction of a Multiple Sclerosis Diagnosis." In 2013 IEEE International Conference on Healthcare Informatics (ICHI). IEEE, 2013. http://dx.doi.org/10.1109/ichi.2013.31.

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Velasquez, J. J., X. Suarez, I. Aristizabal, J. Ascencio, and J. Ochoa. "Functional connectivity changes caused by multiple sclerosis." In 2013 Pan American Health Care Exchanges (PAHCE). IEEE, 2013. http://dx.doi.org/10.1109/pahce.2013.6568319.

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Reports on the topic "Multiple sclerosis"

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Giovannoni, Gavin, Helmut Butzkueven, Suhayl Dhib-Jalbut, Jeremy Hobart, Gisela Kobelt, George Pepper, Maria Pia Sormani, Christoph Thalheim, Anthony Traboulsee, and Timothy Vollmer. Brain health: time matters in multiple sclerosis. Oxford PharmaGenesis Ltd., October 2015. http://dx.doi.org/10.21305/msbh.001.

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Zabel, Brian. Targeting Chemerin Receptor CMKLR1 in Multiple Sclerosis. Fort Belvoir, VA: Defense Technical Information Center, September 2012. http://dx.doi.org/10.21236/ada575594.

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Pepper, George, Helmut Butzkueven, Suhayl Dhib-Jalbut, Gavin Giovannoni, Eva Havrdová, Jeremy Hobart, Gisela Kobelt, et al. Brain health: a guide for people with multiple sclerosis. Oxford PharmaGenesis Ltd., July 2016. http://dx.doi.org/10.21305/msbh.002.

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Yang, In H. Development of Novel Microfluidic Platform for Multiple Sclerosis Study. Fort Belvoir, VA: Defense Technical Information Center, August 2013. http://dx.doi.org/10.21236/ada584505.

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Timm, Eliane, Julia Vieregg, and Ursula Wolf. Movement based mindfulness therapies in patients with multiple sclerosis – a systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, February 2022. http://dx.doi.org/10.37766/inplasy2022.2.0102.

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Review question / Objective: The aim is to review the clinical benefits of mindful moving techniques for persons with multiple sclerosis. Condition being studied: Multiple sclerosis. Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (Gholamzad et al., 2019; Oh, Vidal-Jordana, & Montalban, 2018). It has shown to be increasing since 2013, and as of 2020 the estimated number of people with MS is 2.8 million worldwide (Walton et al., 2020). Due accumulation of relapses or gradual progression, disability from MS is worsening over time (Cameron & Nilsagard, 2018), which results in common symptoms like pain, imbalance, weakness, motor disorders, fatigue, depression, and more (Cameron & Nilsagard, 2018; Guicciardi et al., 2019).
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Babteen, Nouf, Lara Kazim, Haneen Mansour, Mariam Alhilali, and Fayaz Khan. The Effects of Trunk on Balance and Gait in Subjects with Multiple Sclerosis : A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, December 2022. http://dx.doi.org/10.37766/inplasy2022.12.0088.

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Review question / Objective: Does the trunk have an effect on balance and gait in patients with multiple sclerosis ? Condition being studied: Multiple sclerosis patients struggle with recurrent falls due to gait and balance deficits thus does trunk stability have an affect on their balance or not. Information sources: Pubmed, Google Scholar, Web of Science, Scopus, and Embase.
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Pham, Thao. Changes in Cerebral Cortical Aquaporin-1 Expression in Multiple Sclerosis. Portland State University Library, January 2015. http://dx.doi.org/10.15760/honors.166.

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Momchilova, Albena, Zlatan Tsonchev, Mariana Hadzhilazova, Rumiana Tzoneva, Alexander Alexandrov, Dimitar Nikolakov, Viktoria Ilieva, and Roumen Pankov. Sphingolipid Metabolism Is Dysregulated in Erythrocytes from Multiple Sclerosis Patient. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, March 2020. http://dx.doi.org/10.7546/crabs.2020.03.17.

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Yang, In H. Development of a Novel Microfluidic Platform for Multiple Sclerosis Study. Fort Belvoir, VA: Defense Technical Information Center, August 2012. http://dx.doi.org/10.21236/ada564418.

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Zhang, Luwen. Epstein Barr Virus and Blood Brain Barrier in Multiple Sclerosis. Fort Belvoir, VA: Defense Technical Information Center, July 2013. http://dx.doi.org/10.21236/ada593294.

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