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Journal articles on the topic 'Multifactorial disorder'

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Author: Grafiati

Published: 4 June 2021

Last updated: 20 February 2023

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1

Surushkina, S. Yu, E. A. Yakovenko, L. S. Chutko, and M. D. Didur. "Dyslexia as a Multifactorial Disorder." Neuroscience and Behavioral Physiology 51, no. 3 (March 2021): 303–8. http://dx.doi.org/10.1007/s11055-021-01072-8.

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2

Rieux-Laucat, F., and A. Magerus-Chatinet. "Autoimmune lymphoproliferative syndrome: a multifactorial disorder." Haematologica 95, no. 11 (October 31, 2010): 1805–7. http://dx.doi.org/10.3324/haematol.2010.030395.

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3

Drossman, Douglas A. "Irritable Bowel Syndrome: A Multifactorial Disorder." Hospital Practice 23, no. 9 (September 15, 1988): 119–33. http://dx.doi.org/10.1080/21548331.1988.11703538.

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4

Coentre, R., D. Barrocas, and P. Levy. "Low Bone Mineral Density and Psychosis: A Multifactorial Relation." European Psychiatry 24, S1 (January 2009): 1. http://dx.doi.org/10.1016/s0924-9338(09)70491-2.

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Aims:Low bone mineral density (BMD) is a major public health issue leading to fractures, pain and disability. The association between psychosis and low bone density has been suggested in the last years.Method:The authors review the literature in Medline database using the words ‘bone mineral density’, ‘psychosis’, ‘antipsychotic’, ‘schizophrenia’, ‘bipolar disorder’ and ‘psychiatry disorders’.Results:Some studies show elevated prevalence of changes in BMD in patients with psychiatry disorders, namely psychosis. These changes are multifactorial, due to therapeutic factors and/or to the disorder per se. The low BMD induced by some antipsychotic drugs has been attributed mostly to hyperprolactinaemia and its consequences. Lithium, carbamazepine, sodium valproate and the use of thyroid-stimulating hormone-suppressive doses of L-thyroxin used in bipolar disorder also have a negative impact on bone health. Patients with psychosis could be vulnerable to bone abnormalities even without treatment, environmental factors like smoking, sedentary lifestyle, decreased exposure to sunlight, alcoholism, dietary deficiencies and polydipsia are partially responsible for that. Also genetic factors (vitamin D receptor gene, estrogen receptor gene etc.) and biological factors (gender, decreased of peak bone mass, abnormalities in immune-inflammatory mechanisms, hypercortisolemia stress-induced etc.) contribute to the abnormalities in bone dynamics in psychosis.Conclusion:The association between low BMD and psychosis has been demonstrated in literature, understanding all the factors involved in this process will help the development of preventive and treatment strategies. A large study including first psychotic episode patients could be useful to distinguish between disorder and drug induced factors of low BMD in psychosis.

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5

Hernandez, Diana, and Elizabeth M. C. Fisher. "Down syndrome genetics: unravelling a multifactorial disorder." Human Molecular Genetics 5, Supplement_1 (September 1996): 1411–16. http://dx.doi.org/10.1093/hmg/5.supplement_1.1411.

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6

Lee, Stella, and Andrew P. Lane. "Chronic Rhinosinusitis as a Multifactorial Inflammatory Disorder." Current Infectious Disease Reports 13, no. 2 (February 1, 2011): 159–68. http://dx.doi.org/10.1007/s11908-011-0166-z.

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7

Iqbal, Khalid, and Inge Grundke-Iqbal. "Alzheimer's disease, a multifactorial disorder seeking multitherapies." Alzheimer's & Dementia 6, no. 5 (September 2010): 420–24. http://dx.doi.org/10.1016/j.jalz.2010.04.006.

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8

Scheinberg, P. "Dementia due to vascular disease--a multifactorial disorder." Stroke 19, no. 10 (October 1988): 1291–99. http://dx.doi.org/10.1161/01.str.19.10.1291.

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9

Benarroch, Eduardo E. "Postural Tachycardia Syndrome: A Heterogeneous and Multifactorial Disorder." Mayo Clinic Proceedings 87, no. 12 (December 2012): 1214–25. http://dx.doi.org/10.1016/j.mayocp.2012.08.013.

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10

Simmons-Alling, Susan, and Sandra Talley. "Bipolar Disorder and Weight Gain: A Multifactorial Assessment." Journal of the American Psychiatric Nurses Association 13, no. 6 (January 2008): 345–52. http://dx.doi.org/10.1177/10783903080130060401.

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11

RUTTER, MICHAEL. "Pathways of genetic influences on psychopathology." European Review 12, no. 1 (February 2004): 19–33. http://dx.doi.org/10.1017/s1062798704000031.

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Quantitative genetics, using data from twin and adoptee studies, has shown substantial genetic influences on all forms of psychiatric disorder; however, with just a few exceptions, the evidence indicates that the disorders are multifactorial, with influences that are both genetic and environmental. In recent years, molecular genetics has begun to identify individual susceptibility genes; examples are given for schizophrenia, attention deficit/hyperactivity disorder, and Alzheimer's disease. Both quantitative and molecular genetics have shown the importance of gene-environment interplay with respect to the commoner disorders of emotions and behaviour. In particular, it has been found that genetic influences moderate people's vulnerability to environmental risks. Five main alternative routes by which genes indirectly (via their effects on proteins) lead to multifactorial psychiatric disorders are described. Four main research issues are highlighted: the fuller delineation of the mechanisms involved in nature–nurture interplay and its role in aetiology; determination of how genes play a role in the neural underpinning of psychiatric disorders; identification of the ways in which genes suggest a dissection of disorders; and an understanding of the role of risk dimensions and disorder dimensions.

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12

Ghazal, Taher M., Hussam Al Hamadi, Muhammad Umar Nasir, Atta-ur-Rahman, Mohammed Gollapalli, Muhammad Zubair, Muhammad Adnan Khan, and Chan Yeob Yeun. "Supervised Machine Learning Empowered Multifactorial Genetic Inheritance Disorder Prediction." Computational Intelligence and Neuroscience 2022 (May 31, 2022): 1–10. http://dx.doi.org/10.1155/2022/1051388.

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Fatal diseases like cancer, dementia, and diabetes are very dangerous. This leads to fear of death if these are not diagnosed at early stages. Computer science uses biomedical studies to diagnose cancer, dementia, and diabetes. With the advancement of machine learning, there are various techniques which are accessible to predict and prognosis these diseases based on different datasets. These datasets varied (image datasets and CSV datasets) around the world. So, there is a need for some machine learning classifiers to predict cancer, dementia, and diabetes in a human. In this paper, we used a multifactorial genetic inheritance disorder dataset to predict cancer, dementia, and diabetes. Several studies used different machine learning classifiers to predict cancer, dementia, and diabetes separately with the help of different types of datasets. So, in this paper, multiclass classification proposed methodology used support vector machine (SVM) and K-nearest neighbor (KNN) machine learning techniques to predict three diseases and compared these techniques based on accuracy. Simulation results have shown that the proposed model of SVM and KNN for prediction of dementia, cancer, and diabetes from multifactorial genetic inheritance disorder achieved 92.8% and 92.5%, 92.8% and 91.2% accuracy during training and testing, respectively. So, it is observed that proposed SVM-based dementia, cancer, and diabetes from multifactorial genetic inheritance disorder prediction (MGIDP) give attractive results as compared with the proposed model of KNN. The application of the proposed model helps to prognosis and prediction of cancer, dementia, and diabetes before time and plays a vital role to minimize the death ratio around the world.

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13

Bruce, K. D., and C. D. Byrne. "The metabolic syndrome: common origins of a multifactorial disorder." Postgraduate Medical Journal 85, no. 1009 (November 1, 2009): 614–21. http://dx.doi.org/10.1136/pgmj.2008.078014.

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14

Casarrubias-Jaimez, Ana I., Ana Laura Juárez-López, Efraín Tovar-Sánchez, José Luis Rosas-Acevedo, Maximino Reyes-Umaña, América Libertad Rodríguez-Herrera, and Fernando Ramos-Quintana. "Dealing with the Understanding of the Dynamics Related to Multifactorial Temporal Interactions That Spatially Affect the Landscape of Coastal Lagoons." Water 13, no. 15 (July 31, 2021): 2099. http://dx.doi.org/10.3390/w13152099.

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Models based on multifactorial interactions are needed to deal with the dynamics taking place in the eutrophication processes of coastal lagoons. However, as the number of indirect drivers stemming from anthropogenic factors increases, temporal disorders between anthropogenic activities may increase, thus hindering the understanding of their dynamics. We have built multifactorial pathways to deal with the dynamics associated with the cultural eutrophication process of a coastal lagoon. The pathways guided the identification of potential temporal disorder patterns between anthropogenic activities, which may exert influence on the disturbances associated with eutrophication process. The identification of temporal disorder patterns derived from anthropogenic activities belonging to different pathways resulted in a valuable form of support for analyzing and evaluating relationships between public policies, technological skills and environmental culture programs. All of which exert influence on the eutrophication process, which in turn cause changes on the trophic state and on the landscape of the coastal lagoon. Pathways composed of multifactorial interactions that take into account spatial and temporal aspects, contribute to improving the understanding of the inherent dynamics of the eutrophication process of coastal lagoons. Temporal disorders between anthropogenic activities may be seen to emerge, thus exerting changes on the trophic state and spatial damage on the landscapes of coastal lagoons.

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15

Iglseder, Bernhard, Thomas Frühwald, and Christian Jagsch. "Delirium in geriatric patients." Wiener Medizinische Wochenschrift 172, no. 5-6 (January 10, 2022): 114–21. http://dx.doi.org/10.1007/s10354-021-00904-z.

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SummaryDelirium is the most common acute disorder of cognitive function in older patients. Delirium is life threatening, often under-recognized, serious, and costly. The causes are multifactorial, with old age and neurocognitive disorders as the main risk factors. Etiologies are various and multifactorial, and often related to acute medical illness, adverse drug reactions, or medical complications. To date, diagnosis is clinically based, depending on the presence or absence of certain features. In view of the multifactorial etiology, multicomponent approaches seem most promising for facing patients’ needs. Pharmacological intervention, neither for prevention nor for treatment, has been proven effective unanimously. This article reviews the current clinical practice for delirium in geriatric patients, including etiology, pathophysiology, diagnosis, prognosis, treatment, prevention, and outcomes.

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16

Rahman, Atta-ur, Muhammad Umar Nasir, Mohammed Gollapalli, Suleiman Ali Alsaif, Ahmad S. Almadhor, Shahid Mehmood, Muhammad Adnan Khan, and Amir Mosavi. "IoMT-Based Mitochondrial and Multifactorial Genetic Inheritance Disorder Prediction Using Machine Learning." Computational Intelligence and Neuroscience 2022 (July 21, 2022): 1–8. http://dx.doi.org/10.1155/2022/2650742.

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A genetic disorder is a serious disease that affects a large number of individuals around the world. There are various types of genetic illnesses, however, we focus on mitochondrial and multifactorial genetic disorders for prediction. Genetic illness is caused by a number of factors, including a defective maternal or paternal gene, excessive abortions, a lack of blood cells, and low white blood cell count. For premature or teenage life development, early detection of genetic diseases is crucial. Although it is difficult to forecast genetic disorders ahead of time, this prediction is very critical since a person’s life progress depends on it. Machine learning algorithms are used to diagnose genetic disorders with high accuracy utilizing datasets collected and constructed from a large number of patient medical reports. A lot of studies have been conducted recently employing genome sequencing for illness detection, but fewer studies have been presented using patient medical history. The accuracy of existing studies that use a patient’s history is restricted. The internet of medical things (IoMT) based proposed model for genetic disease prediction in this article uses two separate machine learning algorithms: support vector machine (SVM) and K-Nearest Neighbor (KNN). Experimental results show that SVM has outperformed the KNN and existing prediction methods in terms of accuracy. SVM achieved an accuracy of 94.99% and 86.6% for training and testing, respectively.

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17

Mitchell, Philip, Andrew Mackinnon, and Brent Waters. "The Genetics of Bipolar Disorder." Australian & New Zealand Journal of Psychiatry 27, no. 4 (December 1993): 560–80. http://dx.doi.org/10.3109/00048679309075818.

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Growing interest in the application of molecular biological techniques to psychiatric disorders has reinvigorated interest in the genetics of the psychoses. It is therefore timely to review the current state of knowledge of the genetics of bipolar disorder. Family, twin and adoption studies are all consistent in confirming the strongly heritable nature of this condition. As segregation analyses have been unable to determine the mode of transmission of bipolar disorder, ongoing linkage analyses using DNA markers will be crucial in determining whether this condition is due to a single major gene, a small number of genes, or multifactorial polygenic inheritance.

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18

Malow, Beth, and Angela Maxwell-Horn. "Sleep in Autism." Seminars in Neurology 37, no. 04 (August 2017): 413–18. http://dx.doi.org/10.1055/s-0037-1604353.

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AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder that has increased in prevalence over the last several decades. A significant proportion of children with ASD have comorbid sleep disorders. The interplay between ASD and sleep is multifactorial and bidirectional. There is evidence for physiological differences in ASD that contribute to sleep problems, including sensory overresponsiveness (SOR) and abnormal melatonin production. Comorbidities associated with ASD (attention deficit hyperactivity disorder [ADHD], mood disorders) as well as medications used to treat these comorbidities often have effects on sleep architecture. In this article the authors discuss the etiology and manifestations of sleep disorders in children with ASD, as well as their clinical evaluation and treatment options.

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19

Ansell, Emily B., Anthony Pinto, Maria Orlando Edelen, and Carlos M. Grilo. "Structure of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Criteria for Obsessive—Compulsive Personality Disorder in Patients with Binge Eating Disorder." Canadian Journal of Psychiatry 53, no. 12 (December 2008): 863–67. http://dx.doi.org/10.1177/070674370805301212.

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Objective: To examine 1–, 2–, and 3-factor model structures through confirmatory analytic procedures for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) obsessive–compulsive personality disorder (OCPD) criteria in patients with binge eating disorder (BED). Method: Participants were consecutive outpatients ( n = 263) with binge eating disorder and were assessed with semi-structured interviews. The 8 OCPD criteria were submitted to confirmatory factor analyses in Mplus Version 4.2 (Los Angeles, CA) in which previously identified factor models of OCPD were compared for fit, theoretical relevance, and parsimony. Nested models were compared for significant improvements in model fit. Results: Evaluation of indices of fit in combination with theoretical considerations suggest a multifactorial model is a significant improvement in fit over the current DSM-IV single-factor model of OCPD. Though the data support both 2-and 3-factor models, the 3-factor model is hindered by an underspecified third factor. Conclusion: A multifactorial model of OCPD incorporating the factors perfectionism and rigidity represents the best compromise of fit and theory in modelling the structure of OCPD in patients with BED. A third factor representing miserliness may be relevant in BED populations but needs further development. The perfectionism and rigidity factors may represent distinct intrapersonal and interpersonal attempts at control and may have implications for the assessment of OCPD.

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20

Sosiawan, Agung, Mala Kurniati, Coen Pramono Danudiningrat, Dian Agustin Wahjuningrum, and Indra Mulyawan. "The role of family history as a risk factor for non-syndromic cleft lip and/or palate with multifactorial inheritance." Dental Journal (Majalah Kedokteran Gigi) 54, no. 2 (June 30, 2021): 108. http://dx.doi.org/10.20473/j.djmkg.v54.i2.p108-112.

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Background: Cleft lip with or without cleft palate (CL/P) is a facial growth ‘disorder that occurs during gestation and has multifactorial causes owing to both genetic and environmental factors. Several factors can increase the likelihood of CL/P, and one of them is family history. Differences in results obtained from studies conducted across several countries concerning family history as a risk factor for CL/P suggest there is no consensus on how the condition is inherited. Purpose: This study aims to review the literature on the role of family history as a risk factor contributing to the incidence of non-syndromic CL/P (NSCL/P). Review: This review discusses the etiology of CL/P and the risk factors influencing the incidence of CL/P. The review also examines the criteria for inheriting multifactorial disorders to calculate the risks involved should there be a recurrence of the condition based on family history. Conclusion: CL/P is a type of multifactorial disorder with unclear etiology. Therefore, it is important to investigate the risk factors stemming from family history (which play an important role) related to the recurrence risk. Additionally, there should be focus on increasing genetic education and offering counselling to parents and pregnant women.

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Santosh, Paramala J., and Jatinder Singh. "Drug treatment of autism spectrum disorder and its comorbidities in children and adolescents." BJPsych Advances 22, no. 3 (May 2016): 151–61. http://dx.doi.org/10.1192/apt.bp.115.014597.

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SummaryAutism spectrum disorder (ASD) is a complex, multifactorial disorder, the prevalence of which is rising. Specific biomarkers are yet to be identified for the classic ASD phenotypes, so despite treatment advances, most interventions focus on the comorbid disorders of ASD and have little impact on the underlying pathogenesis of the disorder. This article describes drug treatments that target the core symptoms of ASD and its comorbid conditions in children and adolescents. Difficulties and challenges encountered when treating the most frequent comorbidities are discussed, with emphasis on the safety, tolerability and efficacy of medications. In view of its widespread use, complementary and alternative medicine is also described.

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Tsuang, Ming T., Stephen V. Faraone, and Jerome A. Fleming. "Familial Transmission of Major Affective Disorders." British Journal of Psychiatry 146, no. 3 (March 1985): 268–71. http://dx.doi.org/10.1192/bjp.146.3.268.

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SummaryThe two-threshold multifactorial polygenic (MFP) model was applied to blind family study data, collected in a long-term follow-up and family study of major affective disorders. This model tested whether bipolar and unipolar disorders are manifestations of the same underlying factors or if they are independently caused disorders. The hypothesis that bipolar and unipolar disorders are, respectively, severe and mild forms of the same disorder was supported. There was little evidence for different familial aetiologies for bipolar and unipolar disorders in our sample.

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23

Kasyanov, E. D., G. E. Maso, and A. O. Kibitov. "The role of genetic research with family design in the study of affective disorders." V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, no. 4-1 (December 9, 2019): 106–8. http://dx.doi.org/10.31363/2313-7053-2019-4-1-106-108.

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Affective disorders (recurrent depressive disorder and bipolar affective disorder) are multifactorial and polygenic diseases, which suggests the involvement of multiple neurobiological mechanisms. The phenotype of affective disorders is a heterogeneous group of clinically similar psychopathological symptoms, which also makes it difficult to detect potential biomarkers and new therapeutic targets. To study families at high risk of developing affective disorders using both clinical and molecular genetic approaches can help to study the neurobiological basis of depressive conditions, as well as to identify endophenotypes of affective disorders. The most important criterion for an endophenotype is its heritability, which can be proved only within the framework of the family design of the study. Comprehensive clinical and molecular genetic studies based on family design have the best prospects.

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Harvey, Allison G. "Insomnia, Psychiatric Disorders, and the Transdiagnostic Perspective." Current Directions in Psychological Science 17, no. 5 (October 2008): 299–303. http://dx.doi.org/10.1111/j.1467-8721.2008.00594.x.

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Insomnia commonly occurs along with other psychiatric disorders. I aim to address two issues that arise from this observation. First, insomnia is commonly assumed to be epiphenomenal to the so-called “primary” psychiatric disorder. On the basis of new evidence, I argue instead that insomnia may be an important but under-recognized mechanism in the multifactorial cause and maintenance of psychiatric disorders. Second, insomnia may be a transdiagnostic process—a process that is common across psychiatric disorders. The move to identify and study transdiagnostic processes contrasts with the standard “disorder focused” approach in which classification systems and research programs specialize in a single disorder. The latter approach can neglect the intriguing and potentially important similarities across disorders. If it were feasible to develop transdiagnostic treatments, the public health implications would be startling. Research on the role of sleep in psychiatric disorders and tests of the validity and utility of a transdiagnostic approach provide rich opportunities for improving our understanding of, and the treatment of, psychiatric disorders.

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25

Sinha, DN. "Multiple abnormalities in a foetus: a possibility of multifactorial inheritance disorder." National Journal of Clinical Anatomy 5, no. 1 (2016): 48. http://dx.doi.org/10.4103/2277-4025.297719.

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26

Aikman, N. "The crisis within the South African healthcare system: A multifactorial disorder." South African Journal of Bioethics and Law 12, no. 2 (December 17, 2019): 52. http://dx.doi.org/10.7196/sajbl.2019.v12i2.00694.

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27

Aikman, N. "The crisis within the South African healthcare system: A multifactorial disorder." South African Journal of Bioethics and Law 12, no. 2 (December 17, 2019): 52. http://dx.doi.org/10.7196/sajbl.2019.v12i2.694.

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28

Sinha, D. N. "Multiple abnormalities in a foetus: a possibility of multifactorial inheritance disorder." National Journal of Clinical Anatomy 05, no. 01 (January 2016): 048–50. http://dx.doi.org/10.1055/s-0039-3401588.

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AbstractA female foetus of 3.23 kg was delivered by a primigravida of 23 years, after scanning by ultrasound, depicting findings of oligohydramnios and congenital abnormalities. The foetus showed bilateral polydactyly (six digits) in both upper and lower limbs, polycystic enlarged bilateral kidneys, anencephaly, hypoplastic lung, small heart, deformed liver etc. The deformed foetus appeared to be the product of multifactorial inheritance disorders in sequential manner where survival of the foetus could not be possible beyond a period.

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29

Machado, Rajiv D., and Laura Southgate. "Pulmonary Arterial Hypertension: A Deeper Evaluation of Genetic Risk in the -Omics Era." Genes 12, no. 11 (November 16, 2021): 1798. http://dx.doi.org/10.3390/genes12111798.

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30

Salvadó, M. Josepa, Ester Casanova, Anabel Fernández-Iglesias, Lluis Arola, and Cinta Bladé. "Roles of proanthocyanidin rich extracts in obesity." Food & Function 6, no. 4 (2015): 1053–71. http://dx.doi.org/10.1039/c4fo01035c.

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31

Yu, Zhiping, and Valerie Muehleman. "Eating Disorders and Metabolic Diseases." International Journal of Environmental Research and Public Health 20, no. 3 (January 30, 2023): 2446. http://dx.doi.org/10.3390/ijerph20032446.

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Eating disorders are complex diseases with multifactorial causes. According to the Diagnostic and Statistical Manual of Mental Disorders text version (DSM-5-TR) and the WHO International Classification of Diseases and Related Health Problems (ICD-11), the major types of eating disorders include anorexia nervosa, bulimia nervosa, and binge eating disorder. The prevalence of eating disorders is alarmingly increasing globally. Moreover, the COVID-19 pandemic has led to more development and worsening of eating disorders. Patients with eating disorders exhibit high rates of psychiatric comorbidities and medical comorbidities such as obesity, diabetes, and metabolic syndrome. This paper aims to review and discuss the comorbidities of eating disorders with those metabolic diseases. Eating disorder treatment typically includes a combination of some or all approaches such as psychotherapy, nutrition education, and medications. Early detection and intervention are important for the treatment of eating disorders.

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32

Lewis, Barbara A. "Familial Phonological Disorders." Journal of Speech and Hearing Disorders 55, no. 1 (February 1990): 160–70. http://dx.doi.org/10.1044/jshd.5501.160.

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The pedigrees of 4 children with a severe phonological disorder demonstrating three generations of members with speech/language problems are presented. All 4 probands were female with two mothers, two fathers, and five out of six siblings affected. All pedigrees contained family members with dyslexia and learning disabilities as well as speech disorders. Family members varied in the type of speech problems that they demonstrated and the severity of their disorder, thus suggesting variable expressivity and incomplete penetrance. An autosomal dominant mode, a multifactorial-polygenic model, and a sex-specific threshold model for expression are discussed.

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Weden, Alexander. "The Use of a New Clinical Reasoning Framework to Facilitate The Assessment and Management of Temporomandibular Disorders." Journal of Dentistry and Oral Epidemiology 2, no. 1 (March 2, 2022): 1–11. http://dx.doi.org/10.54289/jdoe2200101.

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Background: Temporomandibular Disorders (TMDs) are the most common form of non-odontogenic orofacial pain. TMDs are considered a biopsychosocial disorder with a multifactorial pathogenesis. Patients with TMDs frequently present with cervical spine disorders, headaches and otological complaints. Physiotherapists are often sought to assess and treat TMDs. The use of a radar graph and triangulation to represent phenotyping patients with complex pain presentations has been discussed in the literature with the aim of supporting the best course of treatment for patients with complex and enigmatic pain presentations.

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Ridolfi, Maria E., Christina M. Temes, Emily K. Fraser, Frances R. Frankenburg, and Mary C. Zanarini. "Perceived Caretaker Malevolence During Childhood Reported by Borderline Patients and Personality-Disordered Comparison Subjects: Description and Prediction." Journal of Personality Disorders 34, no. 5 (October 2020): 699–707. http://dx.doi.org/10.1521/pedi_2019_33_446.

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This study has two purposes. The first is to assess the rates of childhood malevolence by caretakers reported by a well-defined sample of inpatients with borderline personality disorder (BPD) and comparison subjects with other personality disorders. The second purpose is to determine the relationship between reported malevolence of caretakers and possible risk factors for this experience. Two reliable interviews were administered to 290 borderline inpatients and 72 personality-disordered comparison subjects to address these aims. Malevolence was reported by a significantly higher percentage of borderline patients than comparison subjects (58% vs. 33%). In multivariate analyses, severity of other forms of abuse, severity of neglect, and a family history of a dramatic cluster personality disorder were found to significantly predict perceived malevolence. Taken together, the results of this study suggest that experiencing malevolence is common and distinguishing for BPD, and that the risk factors for reported childhood malevolence are multifactorial in nature.

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35

Pugh, Matthew. "Understanding ‘Ed’: A theoretical and empirical review of the internal eating disorder ‘voice’." Psychotherapy Section Review 1, no. 65 (2020): 12–23. http://dx.doi.org/10.53841/bpspsr.2020.1.65.12.

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Many individuals with eating disorders make reference to an internal eating disorder ‘voice’ or ‘self’ (EDV/S): a phenomenon which is poorly understood. This paper reviews conceptual and empirical literature relating to the EDV/S. Criticisms and controversies surrounding such experiences are also discussed with reference to current research. In order to clarify how and why internal voices contribute to disordered eating, four theoretical frameworks which help contextualise the EDV/S are presented: cognitive theories of voices; interpersonal theories of voices; trauma-based theories of voices; and dialogical self theory. The paper concludes by proposing a preliminary, multifactorial model of the EDV/S which is composed of four maintaining factors: EDV/S dialogical patterns, EDV/S appraisals, EDV/S relating styles, and early trauma and associated interpersonal schemata. Directions for treatment and future research are discussed.

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Ammazzalorso, Alessandra, and Marialuigia Fantacuzzi. "Anticancer Inhibitors." Molecules 27, no. 14 (July 21, 2022): 4650. http://dx.doi.org/10.3390/molecules27144650.

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37

LUTA, Gabriel, Radu LEFTER, Alin CIOBICA, Ioana Miruna BALMUS, Ioannis MAVROUDIS, Sorin Cristian CIMPEANU, and Mirela CIMPEANU. "A Preliminary view on some Genetic Aspects of Irritable Bowel Syndrome with regards to Neuropsychiatric Manifestations –." Annals of the Academy of Romanian Scientists Series on Biological Sciences 11, no. 1 (2022): 104–8. http://dx.doi.org/10.56082/annalsarscibio.2022.1.104.

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Since the newest functional gastrointestinal disorders diagnostic criteria (ROME IV), the formely functional bowel disorder – irritable bowel syndrome (IBS) – is currently known as a common chronic disorder of the brain – gut interaction. The main clinical symptomatology including abdominal pain, discomfort, and altered gastrointestinal motility, as well as the absence of any organic impairment or significant histological changes led to the confirmed hypothesis of multicomponent pathology and multifactorial etiogenesis. Thus, considering our previous experience in this area of research, this mini-review aimed to present a preliminary view of the possible genetic component underlying or predisposing to neurolopsychiatric and gastrointestinal impairments co-ocurring in IBS.

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Richards, R., DK Kinney, H. Daniels, and K. Linkins. "Everyday creativity and bipolar and unipolar affective disorder: preliminary study of personal and family history." European Psychiatry 7, no. 2 (1992): 49–52. http://dx.doi.org/10.1017/s092493380000328x.

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SummaryPreliminary new data support the enhancement of ‘everyday’ creativity among those persons with bipolar disorders who manifest milder rather than more severe mood elevations, and among certain individuals who are likely to carry bipolar liability but themselves show no clinical mood elevations – in this case, unipolar depressives with a family history of bipolar disorder, when compared with depressives lacking this history. Creativity was assessed using the lifetime creativity scales (Richards el al, 1988). Underlying mechanisms may be multifactorial and complex. Results suggest that both personal and family history should be considered when making predictions concerning creativity and affective disorders.

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Barbosa, Izabela Guimarães, Giulia Campos Ferreira, Diomildo Ferreira Andrade Júnior, Cássio Rocha Januário, André Rolim Belisário, Moises Evandro Bauer, and Ana Cristina Simões e Silva. "The Renin Angiotensin System and Bipolar Disorder: A Systematic Review." Protein & Peptide Letters 27, no. 6 (June 9, 2020): 520–28. http://dx.doi.org/10.2174/0929866527666200127115059.

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Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood, cognition, and functioning. BD is associated with several psychiatric conditions as well clinical comorbidities, particularly cardiovascular diseases. The neurobiology of BD is complex and multifactorial and several systems have been implicated. Considering that the Renin Angiotensin System (RAS) plays an important role in cardiovascular diseases and that recently evidence has suggested its role in psychiatric disorders, the aim of the present study is to summarize and to discuss recent findings related to the modulation of RAS components in BD. A systematic search of the literature using the electronic databases MEDLINE and LILACS was conducted through March 2019. The search terms were: “Bipolar Disorder”; “Renin Angiotensin System”; “Angiotensin 2”; “Angiotensin receptors”; “Angiotensin 1-7”; “ACE”; “ACE2”; “Mas Receptor”. We included original studies assessing RAS in BD patients. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. In the majority of studies (6 of 8), the ACE insertion/deletion (I/D) polymorphism did not differ between BD patients and controls. BD patients presented higher plasma renin activity in comparison with controls. The studies evaluating the RAS molecules in BD are very scarce and heterogeneous. The literature suggests a potential role of RAS in BD. Further studies are necessary to investigate this relationship.

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Maggio, D., A. Cherubim, U. Senin, and D. Lowenthal. "Clinical physiology ? pharmacology: multifactorial hypocalcemia in an elderly patient with myeloproliferative disorder." Geriatric Nephrology and Urology 6, no. 2 (1996): 113–17. http://dx.doi.org/10.1007/bf00451115.

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McIntyre, Roger. "Bipolar Disorder and ADHD: Clinical Concerns." CNS Spectrums 14, S6 (July 2009): 8–9. http://dx.doi.org/10.1017/s1092852900024822.

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During the past decade, a similar composite has emerged for both bipolar disorder and adult attention-deficit/hyperactive disorder (ADHD). First, both conditions have a relatively high prevalence, a low case detection, a protracted illness course, a high rate of comorbidity, multifactorial ideology, substantial heritable liability, and tremendous burden of illness in economic cost as well as interpersonal and vocational maladjustments. What has also been interesting along with these reports is that there has been emerging scientific studies implicating common brain regions and neural circuits subserving essential features of both conditions.

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Araújo, Alexandra Novais, Maria Cunha, Tiago Marques, and Maria João Guerreiro Martins Bugalho. "Multifactorial diabetes insipidus during pregnancy: a challenging diagnosis." BMJ Case Reports 14, no. 3 (March 2021): e238410. http://dx.doi.org/10.1136/bcr-2020-238410.

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Diabetes insipidus (DI) is characterised by thirst and polydipsia with hypotonic polyuria. Several forms exist, namely, central or pituitary, nephrogenic and gestational and must be differentiated for adequate treatment. We describe the case of a 41-year-old woman chronically infected with HIV who had been recently medicated with a tenofovir-based antiretroviral treatment and who, at 22 weeks of pregnancy, presented with transient gestational DI. Obstetric ultrasound revealed oligohydramnios and foetal growth restriction that did not improve despite serum sodium correction. The severity of the case suggested the presence of an underlying disorder and elevated copeptin levels indicated that an underlying subclinical form of nephrogenic DI, possibly induced by HIV-related nephropathy or tenofovir use, was present and rendered clinically overt during pregnancy.

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Aiello, Lisa B., and Beth Desaretz Chiatti. "Primer in Genetics and Genomics, Article 4—Inheritance Patterns." Biological Research For Nursing 19, no. 4 (May 22, 2017): 465–72. http://dx.doi.org/10.1177/1099800417708616.

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Since the completion of the Human Genome Project, much has been uncovered about inheritance of various illnesses and disorders. There are two main types of inheritance: Mendelian and non-Mendelian. Mendelian inheritance includes autosomal dominant, autosomal recessive, X-linked, and Y-linked inheritance. Non-Mendelian inheritance includes mitochondrial and multifactorial inheritance. Nurses must understand the types of inheritance in order to identify red flags that may indicate the possibility of a hereditary disorder in a patient or family.

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Theodoridou, Daniela, Pavlos Christodoulides, Victoria Zakopoulou, and Maria Syrrou. "Developmental Dyslexia: Environment Matters." Brain Sciences 11, no. 6 (June 13, 2021): 782. http://dx.doi.org/10.3390/brainsci11060782.

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Developmental dyslexia (DD) is a multifactorial, specific learning disorder. Susceptibility genes have been identified, but there is growing evidence that environmental factors, and especially stress, may act as triggering factors that determine an individual’s risk of developing DD. In DD, as in most complex phenotypes, the presence of a genetic mutation fails to explain the broad phenotypic spectrum observed. Early life stress has been repeatedly associated with the risk of multifactorial disorders, due to its effects on chromatin regulation, gene expression, HPA axis function and its long-term effects on the systemic stress response. Based on recent evidence, we discuss the potential role of stress on DD occurrence, its putative epigenetic effects on the HPA axis of affected individuals, as well as the necessity of early and appropriate intervention, based on the individual stress-associated (endo)phenotype.

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Ahmad, Syed Ansar, Shamimul Hasan, Shazina Saeed, Ateeba Khan, and Munna Khan. "Low-level laser therapy in temporomandibular joint disorders: a systematic review." Journal of Medicine and Life 14, no. 2 (March 2021): 148–64. http://dx.doi.org/10.25122/jml-2020-0169.

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Temporomandibular joint disorders (TMDs) encompass a wide array of ailments affecting the temporomandibular joint (TMJ), muscles of mastication, and the allied structural framework. Myofascial pain, internal derangement of the joint, and degenerative joint diseases constitute the majority of TMDs. TMDs usually have a multifactorial etiology, and treatment modalities range from conservative therapies to surgical interventions. Low-level laser therapy (LLLT) has evolved as an efficient non-invasive therapeutic modality in TMDs. Previously conducted systematic reviews and meta-analyses have shown variable results regarding the efficiency of LLLT in TMJ disorder patients. Hence, this systematic review was carried out as an attempt to evaluate the efficacy of LLLT in the treatment of temporomandibular joint disorder patients.

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Galiatsatos, Polymnia, Adrian Gologan, and Esther Lamoureux. "Autistic Enterocolitis: Fact or Fiction?" Canadian Journal of Gastroenterology 23, no. 2 (2009): 95–98. http://dx.doi.org/10.1155/2009/394317.

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Autism spectrum disorder refers to syndromes of varying severity, typified by impaired social interactions, communicative delays and restricted, repetitive behaviours and interests. The prevalence of autism spectrum disorders has been on the rise, while the etiology remains unclear and most likely multifactorial. There have been several reports of a link between autism and chronic gastrointestinal symptoms. Endoscopy trials have demonstrated a higher prevalence of nonspecific colitis, lymphoid hyperplasia and focally enhanced gastritis compared with controls. Postulated mechanisms include aberrant immune responses to some dietary proteins, abnormal intestinal permeability and unfavourable gut microflora. Two autism spectrum disorder patients with chronic intestinal symptoms and abnormal endoscopic findings are described, followed by a review of this controversial topic.

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Cacabelos, Ramón, Vinogran Naidoo, Olaia Martínez-Iglesias, Lola Corzo, Natalia Cacabelos, Rocío Pego, and Juan C. Carril. "Personalized Management and Treatment of Alzheimer’s Disease." Life 12, no. 3 (March 21, 2022): 460. http://dx.doi.org/10.3390/life12030460.

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Alzheimer’s disease (AD) is a priority health problem with a high cost to society and a large consumption of medical and social resources. The management of AD patients is complex and multidisciplinary. Over 90% of patients suffer from concomitant diseases and require personalized therapeutic regimens to reduce adverse drug reactions (ADRs), drug–drug interactions (DDIs), and unnecessary costs. Men and women show substantial differences in their AD-related phenotypes. Genomic, epigenetic, neuroimaging, and biochemical biomarkers are useful for predictive and differential diagnosis. The most frequent concomitant diseases include hypertension (>25%), obesity (>70%), diabetes mellitus type 2 (>25%), hypercholesterolemia (40%), hypertriglyceridemia (20%), metabolic syndrome (20%), hepatobiliary disorder (15%), endocrine/metabolic disorders (>20%), cardiovascular disorder (40%), cerebrovascular disorder (60–90%), neuropsychiatric disorders (60–90%), and cancer (10%). Over 90% of AD patients require multifactorial treatments with risk of ADRs and DDIs. The implementation of pharmacogenetics in clinical practice can help optimize the limited therapeutic resources available to treat AD and personalize the use of anti-dementia drugs, in combination with other medications, for the treatment of concomitant disorders.

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Capobianco, Micaela, and Luca Cerniglia. "Communicative, cognitive and emotional issues in selective mutism." Interaction Studies 19, no. 3 (December 31, 2018): 445–58. http://dx.doi.org/10.1075/is.17018.cap.

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Abstract Selective mutism (SM) is a developmental disorder characterized by a child’s inability to speak in certain contexts and/or in the presence of unfamiliar interlocutors. This work proposes a critical discussion of the most recent studies on SM, with respect to clinical and diagnostic features, as well as the etiology and treatment of this disorder. At present, all research work supports the hypothesis that SM is a complex anxiety disorder with multifactorial etiology (interaction among biological and environmental causes). The latest edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013) places SM mutism among “Anxiety Disorders”, and no longer among “Other Childhood, Infant and Adolescent Disorders” (as in DSM-IV). Other important aspects relate to cognitive biases and emotional states at the base of SM, which partly explain the disorder’s persistence and represent an important objective of intervention work. No data in the literature point to a total remission of SM, but good results are achieved with cognitive behavior intervention and multimodal therapy (MMT) involving a variety of child interaction contexts.

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Ramos-Quiroga, J. A. "Treating adult ADHD and comorbid substance-related disorders." European Psychiatry 33, S1 (March 2016): S54. http://dx.doi.org/10.1016/j.eurpsy.2016.01.930.

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Attention-deficit/hyperactivity disorder (ADHD) is a complex, and multifactorial and chronic neurodevelopmental disorder. Comorbid psychiatric disorders are highly prevalent in individuals with a diagnosis of ADHD. There is a solid overlap between ADHD and substance use disorders (SUD). Prevalence of SUD is high among patients with ADHD, so that SUD are approximately double as common among individuals with ADHD than in general population, and individuals with SUD have much higher rates than expected of a comorbid ADHD. Studies shown that treatment during childhood of attention-deficit/hyperactivity disorder with stimulant medication neither protects nor increases the risk of later substance use disorders. Nevertheless, recent studies found that patients with ADHD and SUD can reduce ADHD symptoms and SUD with stimulants and cognitive-behavioral therapy. Treatment of ADHD in patients with SUD requires a comprehensive diagnostic assessment. It is recommendable to stabilize the addiction prior to treating the ADHD. In this talk, the recent literature for the treatment of adults with co-occurring ADHD and SUD will be reviewed.Disclosure of interestThe author has not supplied his declaration of competing interest.

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Shah, Aneesha, and Ambareen Naqvi. "Temporomandibular disorder: A guide for general dental practitioners." Primary Dental Journal 11, no. 3 (September 2022): 118–25. http://dx.doi.org/10.1177/20501684221112513.

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The presentation of patients with symptoms associated with temporomandibular disorders (TMDs) is a common finding in general dental practice. The management of patients with TMDs is often complicated by its multifactorial aetiology. This paper aims to provide a guide for dental practitioners to the clinical examination, diagnosis, and recognition of red flags in relation to TMDs and inform the busy practitioner when to refer patients presenting with TMDs for specialist/secondary care management.

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