Relevant bibliographies by topics / Multifactorial disease; Osteoarthritis

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Academic literature on the topic 'Multifactorial disease; Osteoarthritis'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Multifactorial disease; Osteoarthritis"

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Cornelis, Frederique M. F., Silvia Monteagudo, Laura-An K. A. Guns, Wouter den Hollander, Rob G. H. H. Nelissen, Lies Storms, Tine Peeters, Ilse Jonkers, Ingrid Meulenbelt, and Rik J. Lories. "ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone." Science Translational Medicine 10, no. 458 (September 12, 2018): eaar8426. http://dx.doi.org/10.1126/scitranslmed.aar8426.

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Osteoarthritis is the most common joint disorder with increasing global prevalence due to aging of the population. Current therapy is limited to symptom relief, yet there is no cure. Its multifactorial etiology includes oxidative stress and overproduction of reactive oxygen species, but the regulation of these processes in the joint is insufficiently understood. We report that ANP32A protects the cartilage against oxidative stress, preventing osteoarthritis development and disease progression. ANP32A is down-regulated in human and mouse osteoarthritic cartilage. Microarray profiling revealed that ANP32A protects the joint by promoting the expression of ATM, a key regulator of the cellular oxidative defense. Antioxidant treatment reduced the severity of osteoarthritis, osteopenia, and cerebellar ataxia features in Anp32a-deficient mice, revealing that the ANP32A/ATM axis discovered in cartilage is also present in brain and bone. Our findings indicate that modulating ANP32A signaling could help manage oxidative stress in cartilage, brain, and bone with therapeutic implications for osteoarthritis, neurological disease, and osteoporosis.
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De Francesco, Francesco, Pasquale Gravina, Alice Busato, Luca Farinelli, Carlo Soranzo, Luis Vidal, Nicola Zingaretti, et al. "Stem Cells in Autologous Microfragmented Adipose Tissue: Current Perspectives in Osteoarthritis Disease." International Journal of Molecular Sciences 22, no. 19 (September 22, 2021): 10197. http://dx.doi.org/10.3390/ijms221910197.

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Osteoarthritis (OA) is a chronic debilitating disorder causing pain and gradual degeneration of weight-bearing joints with detrimental effects on cartilage volume as well as cartilage damage, generating inflammation in the joint structure. The etiology of OA is multifactorial. Currently, therapies are mainly addressing the physical and occupational aspects of osteoarthritis using pharmacologic pain treatment and/or surgery to manage the symptomatology of the disease with no specific regard to disease progression or prevention. Herein, we highlight alternative therapeutics for OA specifically considering innovative and encouraging translational methods with the use of adipose mesenchymal stem cells.
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Yunus, Mohd Heikal Mohd, Abid Nordin, and Haziq Kamal. "Pathophysiological Perspective of Osteoarthritis." Medicina 56, no. 11 (November 16, 2020): 614. http://dx.doi.org/10.3390/medicina56110614.

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Osteoarthritis (OA) is the most well-known degenerative disease among the geriatric and is a main cause of significant disability in daily living. It has a multifactorial etiology and is characterized by pathological changes in the knee joint structure including cartilage erosion, synovial inflammation, and subchondral sclerosis with osteophyte formation. To date, no efficient treatment is capable of altering the pathological progression of OA, and current therapy is broadly divided into pharmacological and nonpharmacological measures prior to surgical intervention. In this review, the significant risk factors and mediators, such as cytokines, proteolytic enzymes, and nitric oxide, that trigger the loss of the normal homeostasis and structural changes in the articular cartilage during the progression of OA are described. As the understanding of the mechanisms underlying OA improves, treatments are being developed that target specific mediators thought to promote the cartilage destruction that results from imbalanced catabolic and anabolic activity in the joint.
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Zacharjasz, Julian, Anna M. Mleczko, Paweł Bąkowski, Tomasz Piontek, and Kamilla Bąkowska-Żywicka. "Small Noncoding RNAs in Knee Osteoarthritis: The Role of MicroRNAs and tRNA-Derived Fragments." International Journal of Molecular Sciences 22, no. 11 (May 27, 2021): 5711. http://dx.doi.org/10.3390/ijms22115711.

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Knee osteoarthritis (OA) is a degenerative knee joint disease that results from the breakdown of joint cartilage and underlying bone, affecting about 3.3% of the world's population. As OA is a multifactorial disease, the underlying pathological process is closely associated with genetic changes in articular cartilage and bone. Many studies have focused on the role of small noncoding RNAs in OA and identified numbers of microRNAs that play important roles in regulating bone and cartilage homeostasis. The connection between other types of small noncoding RNAs, especially tRNA-derived fragments and knee osteoarthritis is still elusive. The observation that there is limited information about small RNAs different than miRNAs in knee OA was very surprising to us, especially given the fact that tRNA fragments are known to participate in a plethora of human diseases and a portion of them are even more abundant than miRNAs. Inspired by these findings, in this review we have summarized the possible involvement of microRNAs and tRNA-derived fragments in the pathology of knee osteoarthritis.
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Anikin, S. G., and L. I. Alekseeva. "Etoricoxib in the treatment of osteoarthritis." Meditsinskiy sovet = Medical Council, no. 2 (March 4, 2020): 97–102. http://dx.doi.org/10.21518/2079-701x-2020-2-97-102.

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Osteoarthritis (OA) is one of the most common diseases of the musculoskeletal system.The main symptoms of osteoarthritis are pain, stiffness, joint swelling. According to epidemiological studies, about one-third of the chronic moderate and severe pain is associated with OA. Currently, OA is considered as a multifactorial disease resulting from the interaction of various genetic, biological, mechanical, and metabolic factors. Inflammation plays a central role in development and progression of ОА. In patients with OA, histological studies of the synovial membrane detected signs of chronic inflammation. The level of some proinflammatory cytokines may increased and the level of anti-inflammatory cytokines may decreased in blood serum, synovial fluid and joint tissue. Also, adaptive immune cell responses are detected in the joint tissues in patients of OA. Due to its high effectiveness, non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in OA. Oral or local forms of NSAIDs are the drugs of choice in the initial stages of therapy in all guidelines. Etoricoxib is a selective inhibitor of cyclooxygenase 2 (COX-2) and is used for the treatment of OA and other rheumatic diseases. The article discusses the use of etoricoxib in patients with OA.
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6

Viswanath, J., Chakrapani Cheekavolu, Renu Dixit, and S. Sankaraiah. "Prevalence of osteoarthritis patients in South Indian hospital." International Journal Of Community Medicine And Public Health 4, no. 8 (July 22, 2017): 3043. http://dx.doi.org/10.18203/2394-6040.ijcmph20173369.

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Background: Osteoarthritis is multifactorial in aetiology. Both systemic factors (e.g. age, sex, genes) and local factors (e.g. muscle weakness, joint deformity) appear to influence the risk of individual joints developing the disease. Methods: Total 60 patient’s prospective data was collected in S.V. Ayurvedic Medical College and Hospital. Collected data were family history, physical activity, illness, addiction, digestive power etc., in patients with osteoarthritis. Results: The study showed 53.33% of previous family history of osteoarthritis and 46.66% were no family history of osteoarthritis. 76.66% gradual disease onset and 23.33% were insidious onset. 100% were having joint pain with swelling. 50% were average digestive power, 36.66% good and 13.33% poor. 30% patients were having addiction of alcohol, 16.66% smoking and alcohol, 16.66% smoking, 3.33% tobacco and 33.33% were no addiction. 66.66% patients were having irregular bowel habit and 33.33% was regular. 41.66% sedentary, 40% active and 18.33% were moderately active. 40% illness was observed during the period of 0-6 months, 30% 1-2 years, 16.66% 6-12 months and 13.33% were 2-5 yrs. 60% cold season and 40% were other seasons. Conclusions: Present study demonstrated that, incidence of osteoarthritis was very high especially in earlier family history of osteoarthritis, gradual disease, joint pain, average digestive power, No addiction, bowel habit Irregular, sedentary, illness during the period of last 6 months and cold season patients.
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Lazetic, Aleksandar, Mirka Lukic-Sarkanovic, Dragan Savic, Oliver Dulic, Srdjan Radic, and Mirko Obradovic. "Knee osteoarthritis and arthroplasty of the knee joint." Medical review 69, suppl. 1 (2016): 41–45. http://dx.doi.org/10.2298/mpns16s1041l.

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According to the Public Health Institute of Vojvodina one of the main causes of morbidity, invalidity and absence from work in Vojvodina are musculoskeletal diseases. Osteoarthritis is a multifactorial joint disease, with catabolism and inflammation in its background. For radiological classification of knee osteoarthritis stage Kellgren-Lawrence scale is used. It consists of five levels, from stage ?0? to stage ?4?. The goal of osteoarthritis treatment is to reduce pain and muscle spasms, improve limb function, prevent joint contractures and train patients to function in everyday life and professional activities. The therapy is divided into conservative (medical and physical) and surgical. Arthroplasty is a surgical procedure that involves destruction of articular surfaces and replacement of degenerative joints with endoprostheses, which result in increased general and working ability. Modern endoprostheses enable a high success rate of the procedure. At the Department of Orthopedics and Traumatology, Clinical Center of Vojvodina in Novi Sad, the first knee aloarthroplasty was performed in 1989. Since then, more than 3000 knee aloarthro?plasties have been done. Clinical patient evaluation was obtained through subjective status, functional evaluation and use of scoring systems. More than 80% of patients had a good or a great score.
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Jarecki, Jaromir. "CARTILAGE AGEING AND TREATMENT POSSIBILITIES." Wiadomości Lekarskie 72, no. 9 (2019): 1671–75. http://dx.doi.org/10.36740/wlek201909112.

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Osteoarthritis is the disease connected with aging which is characterised by progressive degeneration of all elements building the joint but also influencing the muscles constituting motor unit with the affected joint. The effective and unified therapy has not been yet introduced despite the broad multi-site studies concentrating on metabolic pathways responsible for the development of the disease. The reason of which is probably its multifactorial aetiology. The treatment methods are based on decreasing of cartilage destruction activity, retardation of proinflammatory factors activity and fighting with pain. Physiotherapy, movement rehabilitation, painkillers, anti-inflammatory drugs, glucosamine sulphates and hyaluronic acids are used as therapeutic strategies. The methods recently introduced are platelet rich plasma concentrates and stem cells injected directly into the affected joint. The aim of this review article was the presentation of differential therapeutic options offered to patients in different stages of osteoarthritis.
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Miranda-Duarte, Antonio. "DNA Methylation in Osteoarthritis: Current Status and Therapeutic Implications." Open Rheumatology Journal 12, no. 1 (March 30, 2018): 37–49. http://dx.doi.org/10.2174/1874312901812010037.

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Background: Primary Osteoarthritis (OA) is a multifactorial disease in which genetic factors are strongly associated with its development; however, recently it has been observed that epigenetic modifications are also involved in the pathogenesis of OA. DNA methylation is related to gene silencing, and several studies have investigated its role in the loci of different pathways or molecules associated to OA. Objective: This review is focused on the current status of DNA methylation studies related to OA pathogenesis. Method: A review of the literature was conducted on searching in PUBMED for original papers on DNA methylation in OA. Conclusion: The DNA methylation research of loci related to OA pathogenesis has shown a correlation between methylation and gene repression; however, there are some exceptions to this rule. Recently, the development of genome-wide methylation and genome-wide hydroxymethylation profiles has demonstrated that several genes previously associated with OA can have changes in their methylation status, favoring the development of the disease, and these have even shown the role of other epigenetic markers.
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Magnuszewski, Lukasz, Marta Swietek, Agnieszka Kasiukiewicz, Bartlomiej Kuprjanowicz, Jan Baczek, and Zyta Beata Wojszel. "Health, Functional and Nutritional Determinants of Falls Experienced in the Previous Year—A Cross-Sectional Study in a Geriatric Ward." International Journal of Environmental Research and Public Health 17, no. 13 (July 2, 2020): 4768. http://dx.doi.org/10.3390/ijerph17134768.

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Falls are a serious health problem in older adults. A limited number of studies assessed their multifactorial nature in geriatric ward patients. The aim of this study is to explore health, functional and nutritional correlates of experiencing fall(s) in the previous year by older inpatients. A cross-sectional study of patients admitted to the department of geriatrics was conducted. A “faller status” was defined based on positive history of falls in the previous 12 months. Health, functional and nutritional factors associated with falls were evaluated, and multivariable logistic regression analysis models were built. A total of 358 patients (median age 82 (IQR 76–86) years, 77.9% women) were recruited, 43.9% of whom reported falls. The “fallers” presented with a significantly higher number of chronic diseases, higher prevalence of Parkinson’s disease, peripheral arterial disease, chronic osteoarthritis, more frequently reported urinary incontinence and were dependent on others for daily living activities. They had significantly worse results for the assessment of gait, balance and frailty status. The Mini Nutritional Assessment-Short Form scores and the mean value of serum albumin were significantly lower in the fallers’ group. Parkinson’s disease (OR = 2.82, CI—1.07–7.45; p = 0.04) and osteoarthritis (OR = 2.08, CI—1.02–4.23; p = 0.04) were the main variables for the outcome prediction, according to the direct multivariable logistic regression analysis. Our findings suggest that Parkinson’s disease and osteoarthritis are the main predictors independently associated with a history of falls in patients admitted to the geriatric ward, although the influence of some factors may be underestimated due to the tendency of not taking the history of falls in very frail, functionally dependent and bedridden individuals.
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Dissertations / Theses on the topic "Multifactorial disease; Osteoarthritis"

1

Chen, Wen-Ling. "Impulsive loading in gonarthrosis." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268204.

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Books on the topic "Multifactorial disease; Osteoarthritis"

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Brodsky, Marc, and Ann E. Hansen. Pain. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190466268.003.0012.

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Persistent pain is an unpleasant sensory and emotional experience that continues for a prolonged period of time and that may or may not be associated with a recognizable disease process. Older people may suffer from conditions such as knee osteoarthritis, low back pain, neck pain and headache, neuropathic pain, fibromyalgia, and cancer-related pain. Pain may impact physical function, psychological function, and other aspects of quality of life. A thorough history and physical examination may optimally assess a person with a persistent pain complaint in the context of a multifactorial pathway from accumulated impairments in multiple systems. Older people may perceive that integrative medicine treatments based on lifestyle and lower-risk therapies may help them get relief from pain and improve quality of life. Follow-up evaluation of positive and negative effects of therapeutic modalities and medications may guide the treatment plan.
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Journal articles
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