Relevant bibliographies by topics / Multi Stage Design

Academic literature on the topic 'Multi Stage Design'

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Published: 8 September 2023

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Journal articles on the topic "Multi Stage Design"

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Trapeznikov, Kirill, Venkatesh Saligrama, and David Castañón. "Multi-stage classifier design." Machine Learning 92, no. 2-3 (May 14, 2013): 479–502. http://dx.doi.org/10.1007/s10994-013-5349-4.

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OKUI, Kotaro, Toshitake TATENO, and Akira KAKUTA. "3267 Multi-modal Vibration Stage for Alignment of Micro-objects : Design guideline of multi-axis alignment stage." Proceedings of International Conference on Leading Edge Manufacturing in 21st century : LEM21 2011.6 (2011): _3267–1_—_3267–6_. http://dx.doi.org/10.1299/jsmelem.2011.6._3267-1_.

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Wason, James M. S., and Thomas Jaki. "Optimal design of multi-arm multi-stage trials." Statistics in Medicine 31, no. 30 (July 23, 2012): 4269–79. http://dx.doi.org/10.1002/sim.5513.

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SAKAIRI, Ryota, and Masao ARAKAWA. "Multi-stage design for multidisciplinary optimization." Proceedings of Conference of Chugoku-Shikoku Branch 2021.59 (2021): 04c7. http://dx.doi.org/10.1299/jsmecs.2021.59.04c7.

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Eynan, Amit, and Lingxiu Dong. "Design of Flexible Multi-Stage Processes." Production and Operations Management 21, no. 1 (April 15, 2011): 194–203. http://dx.doi.org/10.1111/j.1937-5956.2011.01240.x.

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Kumar, Malay, and Satyandra K. Gupta. "Automated Design of Multi-Stage Molds for Manufacturing Multi-Material Objects." Journal of Mechanical Design 124, no. 3 (August 6, 2002): 399–407. http://dx.doi.org/10.1115/1.1485741.

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This paper describes a geometric algorithm for automated design of multi-stage molds for manufacturing multi-material objects. In multi-stage molding process, the desired multi-material object is produced by carrying out multiple molding operations in a sequence, adding one material in the target object in each mold-stage. We model multi-material objects as an assembly of single-material components. Each mold-stage can add only one type of material. Therefore, we need a sequence of mold-stages such that (1) each mold-stage only adds one single-material component either fully or partially, and (2) the molding sequence completely produces the desired object. In order to find a feasible mold-stage sequence, our algorithm decomposes the multi-material object into a number of homogeneous components to find a feasible sequence of homogeneous components that can be added in a sequence to produce the desired multi-material object. Our algorithm starts with the final object assembly and considers removing components either completely or partially from the object one-at-a-time such that it results in the previous state of the object assembly. If a component can be removed from the target object leaving the previous state of the object assembly a connected solid then we consider such decomposition a valid step in the stage sequence. This step is recursively repeated on new states of the object assembly until the object assembly reaches a state where it only consists of one component. When an object-decomposition has been found that leads to a feasible stage sequence, the gross mold for each stage is computed and decomposed into two or more pieces to facilitate the molding operation. We expect that our algorithm will provide a step towards automating the design of multi-stage molds and therefore will help in reducing the mold design lead-time for multi-stage molds.
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Bahrampour, Peyman, Mansoureh Safari, and Mahmood Baghban Taraghdari. "Modeling Multi-Product Multi-Stage Supply Chain Network Design." Procedia Economics and Finance 36 (2016): 70–80. http://dx.doi.org/10.1016/s2212-5671(16)30017-x.

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Taha, Walid, and Tim Sheard. "Multi-stage programming (poster)." ACM SIGPLAN Notices 32, no. 8 (August 1997): 321. http://dx.doi.org/10.1145/258949.258990.

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Kang, Young-Seok, DongHo Rhee, BongJun Cha, and SooSeok Yang. "Design Strategies for Multi-Stage Axial Turbines." KSFM Journal of Fluid Machinery 17, no. 5 (October 1, 2014): 78–82. http://dx.doi.org/10.5293/kfma.2014.17.5.078.

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Boonpan, Adulyasak, and Sujin Bureerat. "Multi-stage design of an automotive component." International Journal of Vehicle Design 60, no. 1/2 (2012): 84. http://dx.doi.org/10.1504/ijvd.2012.049157.

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Dissertations / Theses on the topic "Multi Stage Design"

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Stampfli, John J. "Design of a two-stage multi-state experimental biogas reactor." Thesis, Massachusetts Institute of Technology, 2020. https://hdl.handle.net/1721.1/127871.

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Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, May, 2020
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 23-25).
Anaerobic digestion is a process that breaks down waste and other feed materials and produces biogas. A biogas reactor, or anaerobic digester, is designed to conduct anaerobic digestion in a closed environment and to collect the produced biogas. This is an important field of study because biogas is a renewable energy source. If it can be produced more efficiently, it may become a feasible alternative source of green energy. This thesis outlines the design of a lab-scale experimental reactor with a large range of functionality. The design permits many different environmental conditions, allowing anaerobic digestion to be thoroughly studied with one setup.
by John J. Stampfli.
S.B.
S.B. Massachusetts Institute of Technology, Department of Mechanical Engineering
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Magirr, Dominic. "Design, conduct and analysis of multi-arm multi-stage clinical trials." Thesis, Lancaster University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664454.

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In this thesis, contributions are made towards improving the design, conduct and analysis of multi-arm multi-stage clinical trials. First, we generalize the Dunnett (1955) test to derive efficacy and futility boundaries for a multi-arm multi-stage clinical trial. We show the boundaries control the familywise error rate in the strong sense. The method is applicable for any number of treatment arms, number of stages and number of patients per treatment per stage. It can be used for a wide variety of boundary types or rules derived from a-spending functions. Additionally, we show how sample size can be computed under a least favourable configuration power requirement and derive formulae for expected sample sizes. Next, we describe a general method for finding a confidence region for a vector of K unknown parameters that is compatible with the decisions of a two-stage closed testing procedure in an adaptive experiment. The closed test procedure is characterized by the fact that rejection or nonrejection of a null hypothesis may depend on the decisions for other hypotheses and the compatible confidence region will, in general, have a complex, nonrectangular shape. We find the smallest Cartesian product of simultaneous confidence intervals containing the region and provide computational shortcuts for calculating the lower bounds for parameters corresponding to the rejected null hypotheses. We illustrate the methodology with a detailed example of an adaptive Phase II/III clinical trial. Finally, using the combination test principle and the conditional error principle, we develop flexible sequential designs for multi-arm clinical trials with early stopping for efficacy and futility. Such designs have the flexibility to cope with a large range of exigencies that may occur in practice. They also have the advantage that test decisions are based on sufficient statistics if the trial proceeds as originally planned.
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Bratton, D. J. "Design issues and extensions of multi-arm multi-stage clinical trials." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1459437/.

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The increasing cost of randomised controlled trials is hindering the rate at which new, effective therapies reach patients. To accelerate drug development, more efficient clinical trial designs are needed. One such design which has had success in speeding up the evaluation of therapies in cancer is the multi-arm multi-stage (MAMS) design. This particular design compares multiple new treatments against a control in a single trial, obviating the need for multiple two-arm studies, and ceases recruitment to poorly performing arms during the study. To further increase efficiency, interim assessments can be based on an intermediate outcome which is on the causal pathway to the primary outcome of the trial, thus allowing phases 2 and 3 of evaluation to be incorporated into a single, seamless design. The MAMS design was initially developed for trials in cancer where time to event outcomes are commonly used. To make it more widely applicable to other disease areas, we first extend the design to other types of outcome measure such as binary. The new designs are then applied to trials in tuberculosis --- a disease area with many new treatments currently in the clinical pipeline and which may therefore benefit from using more efficient trial designs. We then consider more general design issues such as familywise error rate and expected sample size and present calculations of both measures using simulation. Methods are developed for finding designs which have the desired overall operating characteristics and which are the most efficient under particular optimality criteria, known as admissible designs. Guidance is provided for choosing the number of stages and allocation ratio for a particular number of arms and we apply the methods developed in the thesis to existing and hypothetical MAMS trials. Throughout, Stata programs are created and updated to accommodate the use of the methods in practice.
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Despain, Dillon J. "Design Validation of a Multi-Stage Gradually Deploying Stent." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/9163.

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Angioplasty, or the use of rapidly deploying stents, is a common treatment for reopening narrowed vasculature often caused by atherosclerotic plaque. However, in-stent restenosis (ISR) induced by intimal hyperplasia is a common challenge to angioplasty. High impact stresses from current stent deployment processes have been linked to intimal hyperplasia; thus a stent that is gradually deployed over a longer period of time holds potential to mitigate these stresses. This work hypothesizes that resorbable polymeric links can be used as a triggering mechanism to enable repeatably controlled deployment of a compliant nitinol stent design with the eventual goal of reducing intimal hyperplasia. The aims of this work include the structured design process and design validation of a stent intended to meet this challenge. A structured design process was used to develop a multi-stage, gradually deploying nitinol stent in which PDLG (DL-lactide/Glycolide copolymer) bioresorbable links constrained specific mechanical cells within the stent geometry, thus limiting initial deployment to an intermediate diameter and allowing for secondary gradual deployment as the PDLG degraded via a combination of bioresorption and creep. A finite element analysis was carried out to design the link geometry to hold the stent at an intermediate stage (90% of final diameter) upon initial deployment, and enable a gradual secondary deployment phase lasting several minutes. Prototypes were then manufactured and the design was validated in a flow chamber mimicking the conditions of human blood flow and temperature. Using a camera and image processing methods, the diameter increase of the stents was tracked over time to characterize the secondary gradual deployment process of the stents. Results showed the links constrained the stents to an initial ~90% diameter upon initial deployment, followed by a gradual, secondary deployment with an average 63.2% rise time of 16.2 minutes. Creep was observed to be the primary driver of the gradual deployment, followed by subsequent bioresorption of the material. All prototypes exhibited gradual secondary deployment without any visible delamination of the bioresorbable links from the stent struts. Based on these findings it can be concluded our hypothesis has been demonstrated, and that a feasible gradually deploying stent design has been mechanically validated, preparatory to pre-clinical studies of its efficacy. Prior to clinical application, future in vivo work is needed to compare actual ISR rates with this stent design to other commonly used stent designs in preclinical trials. In addition, further preclinical work is needed to compare ISR rates through several stent design parameters such as initial deployment diameter, gradual deployment rate, final deployment diameter, and stent sizes to give insights into the optimal stent design. We anticipate that this gradually expanding stent design could reduce in-stent restenosis and improve clinical outcomes.
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Agarwal, Pranab. "Conceptual design of long-span trusses using multi-stage heuristics." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969.1/3863.

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A hybrid method that addresses the design and optimization of long-span steel trusses is presented. By utilizing advancements in present day computing and biologically inspired analysis and design, an effort has been made to automate the process of evolving optimal trusses in an unstructured problem domain. Topology, geometry and sizing optimization of trusses are simultaneously addressed using a three stage methodology. Multi-objective genetic algorithms are used to optimize the member section sizes of truss topologies and geometries. Converting constraints into additional objectives provides a robust algorithm that results in improved convergence to the pareto-optimal set of solutions. In addition, the pareto-curve plotted based on how well the different objectives are satisfied helps in identifying the trade-offs that exist between these objectives, while also providing an efficient way to rank the population of solutions during the search process. A comparison study between multi-objective genetic algorithms, simulated annealing, and reactive taboo search is conducted to evaluate the efficiency of each method with relation to its overall performance, computational expense, sensitivity to initial parameter settings, and repeatability of finding near-global optimal designs. The benefit of using a three stage approach, and also implementing the entire model on parallel computers, is the high level of computational efficiency that is obtained for the entire process and the near-optimal solutions obtained. The overall efficiency and effectiveness of this method has been established by comparing the truss design results obtained using this method on bridge and roof truss benchmark problems with truss designs obtained by other researchers. One of the salient features of thisresearch is the large number of optimal trusses that are produced as the final result. The range of designs available provides the user with the flexibility to select the truss design that best matches their design requirements. By supporting human-computer interactions between these stages, the program also incorporates subjective aesthetic criteria, which assist in producing final designs in consonance with the user's requirements.
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Sigvant, John. "Conceptual Design of an Air- launched Multi-stage Launch Vehicle." Thesis, KTH, Fysik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-284355.

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In the present thesis, the objective was to find the maximum amount of payload mass that can be put into a 500 km polar orbit by a 1400 kg air-launched multi-stage rocket launched from a fighter jet platform. To fulfill the objective an algorithm incorporating several modules was developed. The modules performed calculations based on theoretical models and literature values to arrive at optimal design variables. From the design the maximum payload mass was able to be derived and it was concluded that a three-stage launch vehicle was able to deliver a 22.0 kg payload to the desired orbit.
I den här avhandlingen var syftet att hitta den maximala mängden nyttolastmassa som kan transporteras av en 1400 kg flerstegsraket uppskjuten från luften till en 500 km polär bana. För att uppfylla målet utvecklades en algoritm med flera moduler. Modulerna utförde beräkningar baserade på teoretiska modeller och litteraturvärden för att komma fram till optimala designvariabler. Från konstruktionen kunde den maximala nyttolastmassan härledas och det konstaterades att en trestegsraket kunde leverera en nyttolast på 22.0 kg till den önskade omloppsbanan.
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Bert, Jérôme. "Application of a design optimization strategy to multi-stage compressor matching." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36171.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2006.
Includes bibliographical references (p. 96-97).
A major challenge in the design of multi-stage compressors is the matching of stages to enable stable operation over a large range of mass flows and operating conditions. Particularly in turbofan low-pressure compressors, where a variable geometry cannot be implemented, design strategies for maximum efficiency at high speed can compromise the surge margin at low speed. In this thesis, a design optimization framework has been implemented to an industry-strength compressor-matching problem. The optimization framework combines a mean-line flow solver and a dynamic stability analysis of a six-stage low-pressure compressor of a modern turbofan engine to optimize the blade row geometry for enhanced stability at flight idle conditions. To assess the potential improvements in compressor stability at low speed, a number of optimization strategies are employed using different objective functions and stability metrics. To estimate the performance and stability of the six-stage compressor, a mean-line flow solver is developed and coupled with a previously developed dynamic compressor-stability analysis. A fan-root flow model and an endwall loss correlation are developed using performance data provided by industry.
(cont.) The analysis reveals that the models enable an adequate estimation of the datum compressor performance. This methodology is then used in an optimization effort searching for the optimum compressor design. A compressor blade parametrization based on Bezier splines is developed to explore a range of possible blade geometries. A CFD-based blade-row performance database is established using the blade-to-blade solver MISES. This facilitates an effective means to predict the blade performance for various geometries defined by the optimizer. To find the best solution for the compressor-matching problem, a number of optimization strategies are applied to the datum compressor. The best result is obtained using an optimization strategy based on industry surge margin. An improvement of 14.8% in flight idle surge margin is achieved while maintaining the design pressure ratio and efficiency at climb speed within 1% and 0.3 points of the design values respectively. A compressor design optimization based on a dynamic-stability metric is also employed. Due to time constraints, this strategy could not be fully explored and the preliminary results suggest that further work is required.
(cont.) The best results is a 14.8% improvement in the flight idle surge margin, but the re-matching of the compressor and the associated increase in the rotor loading of the second stage entail high-risk design modifications. This suggests that, given these design limitations, the best matching is achieved by the datum configuration. In summary, the thesis demonstrates that the developed compressor design optimization methodology is applicable to industry-strength design problems, and the framework is shown to have the potential to investigate compressor designs for optimum matching.
by Jérôme Bert.
S.M.
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Almasarwah, Najat E. MASARWAH. "Multi-Stage Cellular Manufacturing System Design under Certain and Uncertain Conditions." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1605028865095297.

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Neverov, Gregory Michael. "Design and implementation of a multi-stage, object-oriented programming language." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16559/1/Gregory_Michael_Neverov_Thesis.pdf.

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Multi-stage programming is a valuable technique for improving the performance of computer programs through run-time optimization. Current implementations of multi-stage programming do not support run-time type introspection, which is a significant feature of modern object-oriented platforms such as Java and C#. This is unfortunate because many programs that use type introspection in these languages could be improved with multi-staging programming. The aim of this research is to investigate the interaction between multi-stage programming and object-oriented type introspection. This is done by the invention of a new programming language that is a multi-stage extension to C#. The language is capable of expressing traditional multi-stage programs as well as a new style of multi-stage programs that incorporate type introspection, most notably polytypic algorithms such as object serialization. A compiler for the language is implemented and freely available. The language is significant because it is the first object-oriented, multi-stage language; the first attempt to combine type introspection with multi-stage programming; and the first exploration of polytypic programming in a multi-stage context.
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Neverov, Gregory Michael. "Design and implementation of a multi-stage, object-oriented programming language." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16559/.

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Multi-stage programming is a valuable technique for improving the performance of computer programs through run-time optimization. Current implementations of multi-stage programming do not support run-time type introspection, which is a significant feature of modern object-oriented platforms such as Java and C#. This is unfortunate because many programs that use type introspection in these languages could be improved with multi-staging programming. The aim of this research is to investigate the interaction between multi-stage programming and object-oriented type introspection. This is done by the invention of a new programming language that is a multi-stage extension to C#. The language is capable of expressing traditional multi-stage programs as well as a new style of multi-stage programs that incorporate type introspection, most notably polytypic algorithms such as object serialization. A compiler for the language is implemented and freely available. The language is significant because it is the first object-oriented, multi-stage language; the first attempt to combine type introspection with multi-stage programming; and the first exploration of polytypic programming in a multi-stage context.
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Books on the topic "Multi Stage Design"

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Chatterjee, M. NDDP multi-stage flash desalination process simulator design. Mumbai: Bhabha Atomic Research Centre, 2006.

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Reese, Lynda M. Incorporating content constraints into a multi-stage adaptive testlet design. Newtown, PA: Law School Admission Council, 1999.

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United States. National Aeronautics and Space Administration., ed. An integral equation solution for multi-stage turbomachinery design calculations. [Washington, DC: National Aeronautics and Space Administration, 1993.

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N, Sashi Kumar G., and Bhabha Atomic Research Centre, eds. NDDP multi-stage flash desalination process simulator design "process optimization". Mumbai: Bhabha Atomic Research Centre, 2009.

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Armstrong, Ronald D. A method to determine targets for multi-stage adaptive tests. Newtown, PA: Law School Admission Council, 2005.

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Ju chang yi shu de duo yuan fa zhan yu she ji: Cong ju chang xing shi jie xi wu tai she ji = Theatre art multi-dimensional development and design : analyzes the state design from the theatre style. Xinbei Shi: Airiti Press (Hua yi chu ban), 2012.

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Lesser, Virginia M. A comparison of periodic survey designs employing multi-stage sampling. Chapel Hill, N.C: Dept. of Biostatistics, Univ. of North Carolina at Chapel Hill, 1992.

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Center, Lewis Research, and United States. National Aeronautics and Space Administration., eds. Multi objective controller design for linear systems via optimal interpolation. [Columbus, Ohio]: Ohio State University, 1996.

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Center, Lewis Research, and United States. National Aeronautics and Space Administration., eds. Multi objective controller design for linear systems via optimal interpolation. [Columbus, Ohio]: Ohio State University, 1996.

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Serebryakov, Andrey, and Gennadiy Zhuravlev. Exploitation of oil and gas fields by horizontal wells. ru: INFRA-M Academic Publishing LLC., 2021. http://dx.doi.org/10.12737/971768.

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The textbook describes the design features of offshore horizontal multi-hole production wells, as well as the bottom-hole components of horizontal multi-hole wells. The classification of complications of multi-hole horizontal wells, methods of their prevention and elimination are given. Methods of underground geonavigation of the development of offshore horizontal production wells are proposed. The geological and field bases of operation of horizontal offshore multi-hole oil and gas wells, modes and dynamics of oil, gas and associated water production, methods for calculating dynamic bottom-hole and reservoir pressures are specified. The technologies of operation of offshore horizontal multi-hole wells are presented. The composition and scope of environmental, field and research marine monitoring of the operation of offshore horizontal multi-hole wells and the protection of the marine environment in the production of oil and gas are justified. Meets the requirements of the federal state educational standards of higher education of the latest generation. It is intended for undergraduates of the enlarged group of "Earth Sciences" training areas, as well as for teachers, employees of the fuel and energy complex, industrial geological exploration and oil and gas production enterprises, scientific and design organizations.
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Book chapters on the topic "Multi Stage Design"

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Schobeiri, Meinhard T. "Efficiency of Multi-Stage Turbomachines." In Gas Turbine Design, Components and System Design Integration, 213–23. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-58378-5_7.

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Schobeiri, Meinhard T. "Efficiency of Multi-Stage Turbomachines." In Gas Turbine Design, Components and System Design Integration, 215–24. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-23973-2_7.

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Flannery, John A., and Karen M. Smith. "Narrabeen Lagoon Multi-use Trail Stage 1." In Eco-Landscape Design, 162–67. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-07206-7_19.

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Wason, James. "Design of Multi-Arm, Multi-Stage Trials in Oncology." In Textbook of Clinical Trials in Oncology, 155–82. Boca Raton, Florida : CRC Press, [2019]: Chapman and Hall/CRC, 2019. http://dx.doi.org/10.1201/9781315112084-9.

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Buchanan, Ian, and Roland Leduc. "Probabilistic Design of Multi-Stage Rotating Biological Contactors." In Stochastic and Statistical Methods in Hydrology and Environmental Engineering, 113–25. Dordrecht: Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-017-3081-5_9.

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Slyne, Frank, Bruno Cornaglia, Marco Boselli, and Marco Ruffini. "3-Stage Hierarchical Quality of Service for Multi-tenant Passive Optical Networks." In Optical Network Design and Modeling, 193–203. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-38085-4_17.

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Du, W. H., H. Wu, and L. Zhang. "Off-design Performance Analysis of Multi-Stage Transonic Axial Compressors." In New Trends in Fluid Mechanics Research, 504. Berlin, Heidelberg: Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-75995-9_167.

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Wang, Jie, Zhifang Zhu, Junhao Zeng, Shengtian Yang, and Yisheng Guan. "Novel Design of a Modular Multi-stage Crusher with Adaptive Clearance by TRIZ Method." In Advances in Mechanical Design, 1053–75. Singapore: Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-7381-8_66.

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Ahmed, Imran. "Rapid Calibration of DAC and Gain Errors in a Multi-bit Pipeline Stage." In Pipelined ADC Design and Enhancement Techniques, 65–84. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-8652-5_6.

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Mourtzis, D., M. Doukas, F. Psarommatis, and N. Panopoulos. "Design of Multi-Stage Manufacturing Networks for Personalized Products Using Metaheuristics." In Advances in Sustainable and Competitive Manufacturing Systems, 1263–76. Heidelberg: Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-00557-7_103.

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Conference papers on the topic "Multi Stage Design"

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Krigmont, Henry V. "Multi-Stage Collector Design and Applications." In International Joint Power Generation Conference collocated with TurboExpo 2003. ASMEDC, 2003. http://dx.doi.org/10.1115/ijpgc2003-40021.

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The Multi Stage Collector (MSC™) concept for ultra-fine particulate control not only retains the best advantages of current state-of-the-art technology but also makes significant improvements. The new MSC™ design provides a synergistic combination of both single- and two-stage electrostatic precipitation while incorporating an additional collector-stage by filtering the gas exiting the collector through a barrier collector-zone. This arrangement ensures that essentially all dust would be detained in this final stage. The MSC™ contains multiple narrow and wide zones formed by a plurality of parallel corrugated plates. Enclosed in the narrow zones are discharge electrodes. These electrodes provide a non-uniform electric field leading to corona discharge. The corona discharge causes particulate matter in the gas flow to become charged. Wide regions contain barrier filters thus creating the two-stage precipitator with relatively uniform electric field. In these regions, particles are collected on both plates and on the porous barrier elements, which also act as the final filtering stage. Results of the applications analyses and future development work are discussed. The gas flow analyses with an aid of the CFD model are presented below.
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Metku, Prashanthi, Ramu Seva, Kyung Ki Kim, Yong-Bin Kim, and Minsu Choi. "Parallel decoding for multi-stage BCH decoder." In 2016 International SoC Design Conference (ISOCC). IEEE, 2016. http://dx.doi.org/10.1109/isocc.2016.7799756.

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Retana, Marco C., Leobardo H. Gonzalez, and Jesus C. Cabrera. "Design of multi-phase multi-stage boost converter 100W." In 2017 14th International Conference on Electrical Engineering, Computing Science and Automatic Control (CCE). IEEE, 2017. http://dx.doi.org/10.1109/iceee.2017.8108851.

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Kang, Young Seok, Tae Choon Park, Oh Sik Hwang, and Soo Seok Yang. "Multi Stage Axial Compressor Design and Performance Evaluation." In ASME-JSME-KSME 2011 Joint Fluids Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/ajk2011-22051.

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Recently, needs for Unmanned Air Vehicle (UAV) and small aircraft are increasing and demands for small turbo jet or turbo fan engines are also increasing. Then, size and weight are the two main restrictions in UAV or small aircraft propulsion system applications. One method for resolving such a problem is to increase the pressure rise per stage and to reduce the number of stages. Nowadays, matured compressor aerodynamic design techniques enable us to design highly loaded axial compressors. This paper covers from the design step of a highly loaded transonic axial compressor to the performance test result and its analysis. At the fore part of the paper, aerodynamic process of a multi stage axial compressor is introduced. To satisfy both of the mass flow and pressure rise, the compressor should rotate at a high rotational speed. Therefore the transonic flow field forms in the rotor stages and it is designed with a relatively high pressure rise per stage to satisfy its design target. Basically, one dimensional and quasi three dimensional compressor design were carried with compressor design codes. The compressor stage consists of 3 stages, and the bulk pressure ratio is 2.5. The first stage is burdened with the highest pressure ratio and less pressure rises occur in the following stages. Also it is designed that tip Mach number of the first rotor row does not exceed 1.3. The final design was confirmed by iterating three dimensional CFD calculations to satisfy design target and some design intentions. In the latter part of the paper, its performance test processes are briefly introduced. The performance test result showed that the overall compressor performance targets; pressure ratio and efficiency are well achieved. From the test results, we found some clues for further improvement and optimization of the compressor aerodynamic performance.
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"Modelling and Simulation of Optical Integrated Networks for Early-Stage Design Exploration." In 2016 Summer Simulation Multi-Conference. Society for Modeling and Simulation International (SCS), 2016. http://dx.doi.org/10.22360/summersim.2016.scsc.052.

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VIMALNATH, S., HARIHARAN R, HARIHARAN P, and HARIKARAN S. "Design of Random Number Sequence Generator using Multi-Stage Feedback with Multi-Stage Ring Oscillator." In 2023 7th International Conference on Computing Methodologies and Communication (ICCMC). IEEE, 2023. http://dx.doi.org/10.1109/iccmc56507.2023.10083817.

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Ming, Chen, Quan HouDe, Zhao Huan, and Liang Wei. "Design of High-Speed DDC Based Multi-stage." In 2010 First International Conference on Pervasive Computing, Signal Processing and Applications (PCSPA 2010). IEEE, 2010. http://dx.doi.org/10.1109/pcspa.2010.231.

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Howard, M. A., and S. J. Gallimore. "Viscous Throughflow Modelling for Multi-Stage Compressor Design." In ASME 1992 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1992. http://dx.doi.org/10.1115/92-gt-302.

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An existing throughflow method for axial compressors, which accounts for the effects of spanwise mixing using a turbulent diffusion model, has been extended to include the viscous shear force on the endwall. The use of a shear force, consistent with a no-slip condition, on the annulus walls in the throughflow calculations allows realistic predictions of the velocity and flow angle profiles near the endwalls. The annulus wall boundary layers are therefore incorporated directly in the throughflow prediction. This eliminates the need for empirical blockage factors or independent annulus boundary layer calculations. The axisymmetric prediction can be further refined by specifying realistic spanwise variations of loss coefficient and deviation to model the three-dimensional endwall effects. The resulting throughflow calculation gives realistic predictions of flow properties across the whole span of a compressor. This is confirmed by comparison with measured data from both low and high speed multi-stage machines. The viscous throughflow method has been incorporated into an axial compressor design system. The method predicts the meridional velocity defects in the endwall region and consequently blading can be designed which allows for the increased incidence, and low dynamic head, near to the annulus walls.
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Wolf, Malima I., Marcello Colledani, Stanley B. Gershwin, and Timothy G. Gutowski. "Modeling and design of multi-stage separation systems." In 2010 IEEE International Symposium on Sustainable Systems and Technology (ISSST). IEEE, 2010. http://dx.doi.org/10.1109/issst.2010.5507744.

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Pandey, R. K. "Analysis and design of multi-stage LQR UPFC." In 2010 International Conference on Power, Control and Embedded Systems (ICPCES). IEEE, 2010. http://dx.doi.org/10.1109/icpces.2010.5698644.

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Reports on the topic "Multi Stage Design"

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Kumar, Malay, and Satyandra K. Gupta. A Geometric Algorithm for Automated Design of Multi-Stage Molds for Manufacturing Multi-Material Objects. Fort Belvoir, VA: Defense Technical Information Center, January 2000. http://dx.doi.org/10.21236/ada453546.

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Emelyanov, I. I., N. N. Ziyatdinov, and T. V. Lapteva. Method of computer-aided design of multi-stage heat exchange systems with direct-flow and counter-current flow organization. OFERNIO, December 2020. http://dx.doi.org/10.12731/ofernio.2020.24738.

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Führ, Martin, Julian Schenten, and Silke Kleihauer. Integrating "Green Chemistry" into the Regulatory Framework of European Chemicals Policy. Sonderforschungsgruppe Institutionenanalyse, July 2019. http://dx.doi.org/10.46850/sofia.9783941627727.

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20 years ago a concept of “Green Chemistry” was formulated by Paul Anastas and John Warner, aiming at an ambitious agenda to “green” chemical products and processes. Today the concept, laid down in a set of 12 principles, has found support in various arenas. This diffusion was supported by enhancements of the legislative framework; not only in the European Union. Nevertheless industry actors – whilst generally supporting the idea – still see “cost and perception remain barriers to green chemistry uptake”. Thus, the questions arise how additional incentives as well as measures to address the barriers and impediments can be provided. An analysis addressing these questions has to take into account the institutional context for the relevant actors involved in the issue. And it has to reflect the problem perception of the different stakeholders. The supply chain into which the chemicals are distributed are of pivotal importance since they create the demand pull for chemicals designed in accordance with the “Green Chemistry Principles”. Consequently, the scope of this study includes all stages in a chemical’s life-cycle, including the process of designing and producing the final products to which chemical substances contribute. For each stage the most relevant legislative acts, together establishing the regulatory framework of the “chemicals policy” in the EU are analysed. In a nutshell the main elements of the study can be summarized as follows: Green Chemistry (GC) is the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Besides, reaction efficiency, including energy efficiency, and the use of renewable resources are other motives of Green Chemistry. Putting the GC concept in a broader market context, however, it can only prevail if in the perception of the relevant actors it is linked to tangible business cases. Therefore, the study analyses the product context in which chemistry is to be applied, as well as the substance’s entire life-cycle – in other words, the six stages in product innovation processes): 1. Substance design, 2. Production process, 3. Interaction in the supply chain, 4. Product design, 5. Use phase and 6. After use phase of the product (towards a “circular economy”). The report presents an overview to what extent the existing framework, i.e. legislation and the wider institutional context along the six stages, is setting incentives for actors to adequately address problematic substances and their potential impacts, including the learning processes intended to invoke creativity of various actors to solve challenges posed by these substances. In this respect, measured against the GC and Learning Process assessment criteria, the study identified shortcomings (“delta”) at each stage of product innovation. Some criteria are covered by the regulatory framework and to a relevant extent implemented by the actors. With respect to those criteria, there is thus no priority need for further action. Other criteria are only to a certain degree covered by the regulatory framework, due to various and often interlinked reasons. For those criteria, entry points for options to strengthen or further nuance coverage of the respective principle already exist. Most relevant are the deltas with regard to those instruments that influence the design phase; both for the chemical substance as such and for the end-product containing the substance. Due to the multi-tier supply chains, provisions fostering information, communication and cooperation of the various actors are crucial to underpin the learning processes towards the GCP. The policy options aim to tackle these shortcomings in the context of the respective stage in order to support those actors who are willing to change their attitude and their business decisions towards GC. The findings are in general coherence with the strategies to foster GC identified by the Green Chemistry & Commerce Council.
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Rothe. L51527b State-of-the-Art Report on Multiphase Methods Vol 2. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), December 1986. http://dx.doi.org/10.55274/r0010504.

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Three volumes. Report based on a multi-year effort to develop a Two-Phase Flow Design Manual. Intended to assess the current application of multiphase flow hydraulic methods to system design. Volumes are as follows: Vol. 1, Guide to Quick Calculations; Vol. 2, Guide to Computerized Calculations; and Vol. 3, Theoretical Supplement.
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Rothe. L51527a State-of-the-Art Report on Multiphase Methods Vol 1. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), December 1986. http://dx.doi.org/10.55274/r0010514.

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Three volumes. Report based on a multi-year effort to develop a Two-Phase Flow Design Manual. Intended to assess the current application of multiphase flow hydraulic methods to system design. Volumes are as follows: Vol. 1, Guide to Quick Calculations; Vol. 2, Guide to Computerized Calculations; and Vol. 3, Theoretical Supplement.
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Rothe. L51527c State-of-the-Art Report on Multiphase Methods Vol 3. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), December 1986. http://dx.doi.org/10.55274/r0010508.

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Three volumes. Report based on a multi-year effort to develop a Two-Phase Flow Design Manual. Intended to assess the current application of multiphase flow hydraulic methods to system design. Volumes are as follows: Vol. 1, Guide to Quick Calculations; Vol. 2, Guide to Computerized Calculations; and Vol. 3, Theoretical Supplement.
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Weller, Joel I., Ignacy Misztal, and Micha Ron. Optimization of methodology for genomic selection of moderate and large dairy cattle populations. United States Department of Agriculture, March 2015. http://dx.doi.org/10.32747/2015.7594404.bard.

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The main objectives of this research was to detect the specific polymorphisms responsible for observed quantitative trait loci and develop optimal strategies for genomic evaluations and selection for moderate (Israel) and large (US) dairy cattle populations. A joint evaluation using all phenotypic, pedigree, and genomic data is the optimal strategy. The specific objectives were: 1) to apply strategies for determination of the causative polymorphisms based on the “a posteriori granddaughter design” (APGD), 2) to develop methods to derive unbiased estimates of gene effects derived from SNP chips analyses, 3) to derive optimal single-stage methods to estimate breeding values of animals based on marker, phenotypic and pedigree data, 4) to extend these methods to multi-trait genetic evaluations and 5) to evaluate the results of long-term genomic selection, as compared to traditional selection. Nearly all of these objectives were met. The major achievements were: The APGD and the modified granddaughter designs were applied to the US Holstein population, and regions harboring segregating quantitative trait loci (QTL) were identified for all economic traits of interest. The APGD was able to find segregating QTL for all the economic traits analyzed, and confidence intervals for QTL location ranged from ~5 to 35 million base pairs. Genomic estimated breeding values (GEBV) for milk production traits in the Israeli Holstein population were computed by the single-step method and compared to results for the two-step method. The single-step method was extended to derive GEBV for multi-parity evaluation. Long-term analysis of genomic selection demonstrated that inclusion of pedigree data from previous generations may result in less accurate GEBV. Major conclusions are: Predictions using single-step genomic best linear unbiased prediction (GBLUP) were the least biased, and that method appears to be the best tool for genomic evaluation of a small population, as it automatically accounts for parental index and allows for inclusion of female genomic information without additional steps. None of the methods applied to the Israeli Holstein population were able to derive GEBV for young bulls that were significantly better than parent averages. Thus we confirm previous studies that the main limiting factor for the accuracy of GEBV is the number of bulls with genotypes and progeny tests. Although 36 of the grandsires included in the APGD were genotyped for the BovineHDBeadChip, which includes 777,000 SNPs, we were not able to determine the causative polymorphism for any of the detected QTL. The number of valid unique markers on the BovineHDBeadChip is not sufficient for a reasonable probability to find the causative polymorphisms. Complete resequencing of the genome of approximately 50 bulls will be required, but this could not be accomplished within the framework of the current project due to funding constraints. Inclusion of pedigree data from older generations in the derivation of GEBV may result is less accurate evaluations.
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Ng, Shu Wen, Thomas Hoerger, and Rachel Nugent. Preventing Non-communicable Diseases Using Pricing Policies: Lessons for the United States from Global Experiences and Local Pilots. RTI Press, May 2021. http://dx.doi.org/10.3768/rtipress.2021.pb.0025.2105.

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Preventing non-communicable diseases (NCDs) in an effective and sustainable way will require forward-looking policy solutions that can address multiple objectives. This was true pre–COVID-19 and is even more true now. There are already examples from across the globe and within the United States that show how these may be possible. Although there are still many unknowns around how the design, targeting, level, sequencing, integration, and implementation of fiscal policies together can maximize their NCD prevention potential, there is already clear evidence that health taxes and particularly sugar-sweetened beverage (SSB) taxes are cost-effective. Nonetheless, policies alone may not succeed. Political will to prioritize well-being, protections against industry interference, and public buy-in are necessary. If those elements align, pricing policies that consider the context in question can be designed and implemented to achieve several goals around reducing consumption of unhealthy SSBs and foods, narrowing existing nutritional and health disparities, encouraging economic and social development. The US and its local and state jurisdictions should consider these pricing policy issues and their contexts carefully, in collaboration with community partners and researchers, to design multi-duty actions and to be prepared for future windows of opportunities to open for policy passage and implementation.
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Lyammouri, Rida. Central Mali: Armed Community Mobilization in Crisis. RESOLVE Network, November 2021. http://dx.doi.org/10.37805/cbags2021.4.

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The proliferation of community-based armed groups (CBAGs) in Mali’s Mopti and Ségou Regions has contributed to transforming Central Mali into a regional epicenter of conflict since 2016. Due to the lack of adequate presence of the state, certain vulnerable, conflict-affected communities resorted to embracing non-state armed groups as security umbrellas in the context of inter-communal violence. These local conflicts are the result of long-standing issues over increasing pressure on natural resources, climate shocks, competing economic lifestyles, nepotistic and exclusionary resource management practices, and the shifting representations of a segregated, historically constructed sense of ethnic identities in the region. This report untangles the legitimacy of armed groups, mobilizing factors, and the multi-level impact of violence implicating CBAGs. It further explores the relations amongst different actors, including the state, armed groups, and communities. The findings provide relevant insight for context-specific policy design toward conflict resolution and hybrid security governance.
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Wilson, Thomas E., Avraham A. Levy, and Tzvi Tzfira. Controlling Early Stages of DNA Repair for Gene-targeting Enhancement in Plants. United States Department of Agriculture, March 2012. http://dx.doi.org/10.32747/2012.7697124.bard.

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Gene targeting (GT) is a much needed technology as a tool for plant research and for the precise engineering of crop species. Recent advances in this field have shown that the presence of a DNA double-strand break (DSB) in a genomic locus is critical for the integration of an exogenous DNA molecule introduced into this locus. This integration can occur via either non-homologous end joining (NHEJ) into the break or homologous recombination (HR) between the broken genomic DNA and the introduced vector. A bottleneck for DNA integration via HR is the machinery responsible for homology search and strand invasion. Important proteins in this pathway are Rad51, Rad52 and Rad54. We proposed to combine our respective expertise: on the US side, in the design of zincfinger nucleases (ZFNs) for the induction of DNA DSBs at any desired genomic locus and in the integration of DNA molecules via NHEJ; and on the Israeli side in the HR events, downstream of the DSB, that lead to homology search and strand invasion. We sought to test three major pathways of targeted DNA integration: (i) integration by NHEJ into DSBs induced at desired sites by specially designed ZFNs; (ii) integration into DSBs induced at desired sites combined with the use of Rad51, Rad52 and Rad54 proteins to maximize the chances for efficient and precise HR-mediated vector insertion; (iii) stimulation of HR by Rad51, Rad52 and Rad54 in the absence of DSB induction. We also proposed to study the formation of dsT-DNA molecules during the transformation of plant cells. dsT-DNA molecules are an important substrate for HR and NHEJ-mediatedGT, yet the mode of their formation from single stranded T-DNA molecules is still obscure. In addition we sought to develop a system for assembly of multi-transgene binary vectors by using ZFNs. The latter may facilitate the production of binary vectors that may be ready for genome editing in transgenic plants. ZFNs were proposed for the induction of DSBs in genomic targets, namely, the FtsH2 gene whose loss of function can easily be identified in somatic tissues as white sectors, and the Cruciferin locus whose targeting by a GFP or RFP reporter vectors can give rise to fluorescent seeds. ZFNs were also proposed for the induction of DSBs in artificial targets and for assembly of multi-gene vectors. We finally sought to address two important cell types in terms of relevance to plant transformation, namely GT of germinal (egg) cells by floral dipping, and GT in somatic cells by root and leave transformation. To be successful, we made use of novel optimized expression cassettes that enable coexpression of all of the genes of interest (ZFNs and Rad genes) in the right tissues (egg or root cells) at the right time, namely when the GT vector is delivered into the cells. Methods were proposed for investigating the complementation of T-strands to dsDNA molecules in living plant cells. During the course of this research, we (i) designed, assembled and tested, in vitro, a pair of new ZFNs capable of targeting the Cruciferin gene, (ii) produced transgenic plants which expresses for ZFN monomers for targeting of the FtsH2 gene. Expression of these enzymes is controlled by constitutive or heat shock induced promoters, (iii) produced a large population of transgenic Arabidopsis lines in which mutated mGUS gene was incorporated into different genomic locations, (iv) designed a system for egg-cell-specific expression of ZFNs and RAD genes and initiate GT experiments, (v) demonstrated that we can achieve NHEJ-mediated gene replacement in plant cells (vi) developed a system for ZFN and homing endonuclease-mediated assembly of multigene plant transformation vectors and (vii) explored the mechanism of dsTDNA formation in plant cells. This work has substantially advanced our understanding of the mechanisms of DNA integration into plants and furthered the development of important new tools for GT in plants.
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