Dissertations / Theses on the topic 'Muller cells'
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Walker, Robert J. "Inflammatory cytokines modulated by beta adrenergic receptors on retinal Muller cells in diabetic retinopathy /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1467888651&sid=24&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Full textTretiach, Marina Louise. "Bovine Models of Human Retinal Disease: Effect of Perivascular Cells on Retinal Endothelial Cell Permeability." Thesis, The University of Sydney, 2005. http://hdl.handle.net/2123/1153.
Full textTretiach, Marina Louise. "Bovine Models of Human Retinal Disease: Effect of Perivascular Cells on Retinal Endothelial Cell Permeability." University of Sydney, 2005. http://hdl.handle.net/2123/1153.
Full textBackground: Diabetic vascular complications affect both the macro- and microvasculature. Microvascular pathology in diabetes may be mediated by biochemical factors that precipitate cellular changes at both the gene and protein levels. In the diabetic retina, vascular pathology is found mainly in microvessels, including the retinal precapillary arterioles, capillaries and venules. Macular oedema secondary to breakdown of the inner blood-retinal barrier is the most common cause of vision impairment in diabetic retinopathy. Müller cells play a critical role in the trophic support of retinal neurons and blood vessels. In chronic diabetes, Müller cells are increasingly unable to maintain their supportive functions and may themselves undergo changes that exacerbate the retinal pathology. The consequences of early diabetic changes in retinal cells are primarily considered in this thesis. Aims: This thesis aims to investigate the effect of perivascular cells (Müller cells, RPE, pericytes) on retinal endothelial cell permeability using an established in vitro model. Methods: Immunohistochemistry, cell morphology and cell growth patterns were used to characterise primary bovine retinal cells (Müller cells, RPE, pericytes and endothelial cells). An in vitro model of the blood-retinal barrier was refined by coculturing retinal endothelial cells with perivascular cells (Müller cells or pericytes) on opposite sides of a permeable Transwell filter. The integrity of the barrier formed by endothelial cells was assessed by transendothelial electrical resistance (TEER) measurements. Functional characteristics of endothelial cells were compared with ultrastructural morphology to determine if different cell types have barrier-enhancing effects on endothelial cell cultures. Once the co-culture model was established, retinal endothelial cells and Müller cells were exposed to different environmental conditions (20% oxygen, normoxia; 1% oxygen, hypoxia) to examine the effect of perivascular cells on endothelial cell permeability under reduced oxygen conditions. Barrier integrity was assessed by TEER measurements and permeability was measured by passive diffusion of radiolabelled tracers from the luminal to the abluminal side of the endothelial cell barrier. A further study investigated the mechanism of laser therapy on re-establishment of retinal endothelial cell barrier integrity. Müller cells and RPE, that comprise the scar formed after laser photocoagulation, and control cells (Müller cells and pericytes, RPE cells and ECV304, an epithelial cell line) were grown in long-term culture and treated with blue-green argon laser. Lasered cells were placed underneath confluent retinal endothelial cells growing on a permeable filter, providing conditioned medium to the basal surface of endothelial cells. The effect of conditioned medium on endothelial cell permeability was determined, as above. Results: Co-cultures of retinal endothelial cells and Müller cells on opposite sides of a permeable filter showed that Müller cells can enhance the integrity of the endothelial cell barrier, most likely through soluble factors. Low basal resistances generated by endothelial cells from different retinal isolations may be the result of erratic growth characteristics (determined by ultrastructural studies) or the selection of vessel fragments without true âbarrier characteristicsâ in the isolation step. When Müller cells were co-cultured in close apposition to endothelial cells under normoxic conditions, the barrier integrity was enhanced and permeability was reduced. Under hypoxic conditions, Müller cells had a detrimental effect on the integrity of the endothelial cell barrier and permeability was increased in closely apposed cells. Conditioned medium from long-term cultured Müller cells and RPE that typically comprise the scar formed after lasering, enhanced TEER and reduced permeability of cultured endothelial cells. Conclusions: These studies confirm that bovine tissues can be used as a suitable model to investigate the role of perivascular cells on the permeability of retinal endothelial cells. The dual effect of Müller cells on the retinal endothelial cell barrier under different environmental conditions, underscores the critical role of Müller cells in regulating the blood-retinal barrier in health and disease. These studies also raise the possibility that soluble factor(s) secreted by Müller cells and RPE subsequent to laser treatment reduce the permeability of retinal vascular endothelium. Future studies to identify these factor(s) may have implications for the clinical treatment of macular oedema secondary to diseases including diabetic retinopathy.
Eldred, Megan. "Investigating cellular and molecular mechanisms of neuronal layering in self-organising aggregates of zebrafish retinal cells." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/284080.
Full textGallina, Donika. "The Role of Glucocorticoid Receptor-signaling and Wnt-signaling in Avian Retinal Regeneration." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1439204931.
Full textShelton, Melissa D. "Glutaredoxin Regulation of Pro-Inflammatory Responses in a Model of Diabetic Retinopathy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1224176018.
Full textLycke, Christian. "Ko-Expression des astroglialen GFAP- und des oligodendrozytären PLP-Promotors in Müllerzellen der Retina: Aktivierung durch Läsionen." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-158668.
Full textPringle, R. S. "The role of advanced glycation in the pathogenesis of retinal muller cell dysfunction during diabetes." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517057.
Full textCharlton-Perkins, Mark. "Control of Drosophila Eye Specification, Patterning and Function by the Transcription Factors prospero and Pax2." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1406819630.
Full textAllan, Kristin. "Exploring the Roles of Muller Glia and Activated Leukocyte Cell Adhesion Molecule A in Zebrafish Retinal Regeneration." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1607705752486913.
Full textGörner, Andreas. "Neuron:Glia-Verhältnis in der Netzhaut verschiedener Raubtiere." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-115160.
Full textBürckert, Jean-Philippe [Verfasser], Claude P. [Akademischer Betreuer] Muller, Claude P. [Gutachter] Muller, and Jobst [Gutachter] Meyer. "Characterization of Immunoglobulin Repertoires after Vaccination in OmniRatTM and Monoclonal CD5+ B Cell Expansion in A20BKOsCYLDBOE Mice using an Ion Torrent PGM High-Throughput Sequencing Platform / Jean-Philippe Bürckert ; Gutachter: Claude P. Muller, Jobst Meyer ; Betreuer: Claude P. Muller." Trier : Universität Trier, 2019. http://d-nb.info/1197808671/34.
Full textZhang, Pei [Verfasser], André [Akademischer Betreuer] Fischer, Helene [Gutachter] Marie, Lionel [Gutachter] Dahan, Yoon [Gutachter] Cho, and Christophe [Gutachter] Mulle. "Synaptic modifications in hippocampal CA3 pyramidal cells in an Alzheimer's mouse model / Pei Zhang ; Gutachter: Helene Marie, Lionel Dahan, Yoon Cho, Christophe Mulle ; Betreuer: André Fischer." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/1153607174/34.
Full textCampbell, Warren Alexander IV. "Immunomodulatory Signaling Factors that Regulate Müller Glia Reprogramming and Glial Reactivity." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu1618173564322887.
Full textWoon, W. H., D. Greig, M. D. Savage, M. C. T. Wilson, Colin A. Grant, B. Mokete, and F. Bishop. "Movement of the inner retina complex during the development of primary full-thickness macular holes: implications for hypotheses of pathogenesis." 2015. http://hdl.handle.net/10454/9251.
Full textThe inner retinal complex is a well-defined layer in spectral-domain OCT scans of the retina. The central edge of this layer at the fovea provides anatomical landmarks that can be observed in serial OCT scans of developing full-thickness macular holes (FTMH). Measurement of the movement of these points may clarify the mechanism of FTMH formation. This is a retrospective study of primary FTMH that had a sequence of two OCT scans showing progression of the hole. Measurements were made of the dimensions of the hole, including measurements using the central edge of the inner retinal complex (CEIRC) as markers. The inner retinal separation (distance between the CEIRC across the centre of the fovea) and the Height-IRS (average height of CEIRC above the retinal pigment epithelium) were measured. Eighteen cases were identified in 17 patients. The average increase in the base diameter (368 microns) and the average increase in minimum linear dimension (187 microns) were much larger than the average increase in the inner retinal separation (73 microns). The average increase in Height-IRS was 103 microns. The tangential separation of the outer retina to produce the macular hole is much larger than the tangential separation of the inner retinal layers. A model based on the histology of the Muller cells at the fovea is proposed to explain the findings of this study.
Lycke, Christian. "Ko-Expression des astroglialen GFAP- und des oligodendrozytären PLP-Promotors in Müllerzellen der Retina: Aktivierung durch Läsionen: Ko-Expression des astroglialen GFAP- und desoligodendrozytären PLP-Promotors in Müllerzellen der Retina:Aktivierung durch Läsionen." Doctoral thesis, 2013. https://ul.qucosa.de/id/qucosa%3A13076.
Full textLin, Yi-Jun, and 林怡君. "Toxicity study of lead on the cell activation of Grey mullet(Mugil cephalus)." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/81684386436557167872.
Full text國立臺灣海洋大學
環境生物與漁業科學學系
95
Abstract The cell model of neurotoxicity set up by PC12 cells. The instantaneous drop in the fluorescence responses after added Pb2+ was decreased immediately. This result indicated the contribution of fluorescence quench in PC12 cells under different concentration of Ca2+ and Pb2+. It’s showed the cellular uptake of Pb2+ in real-time. This increased of Indo-1 fluorescence quench with increasing the concentration of Pb2+ occurred in both the extracellular normal Ca2+ and Ca2+ free medium but was most apparent while 20μM Pb2+ was added to PC12 cells in the Ca2+ free medium. In this experiment of the effects on the calcium reaction in PC12 cells by Pb2+. Added ATP(200μM)as a stimulates drug for activates the Ca2+-ATPase. The concentration of calcium reaction in PC12 cell was being inhibited and three times lower than the control(2756.56±40 nM)by obviously, while the Pb2+ added. The digested cell from the gill , muscle , liver , spleen and bowel of Mugil cephalus fry(5.04±0.12 cm of average long, 2.44±0.15 g of average weight)to be experimental subjects. The instantaneous drop in fluorescence after the addition of Pb2+ was always present and indicated the contribution of fluorescence in all organs cells quench under different concentration of Ca2+ by Pb2+. Show that cellular uptake of Pb2+ in real-time. The maximum of Indo-1 fluorescence quench in cells of gill , muscle , liver , spleen and bowel were 41.67±0.23%, 23.80±0.43% , 49.51±0.80% , 40.23±0.63% and 37.66±0.57, respectively. Effects of different contribution of Pb2+ under extracellular different Ca2+ contribution medium, the maximum of Indo-1 fluorescence quench was the liver cell, secondly was spleen and intestinal cell, the least was the muscle cell. Key words: Lead, Grey mullet(Mugil cephalus), Indo-1.
Görner, Andreas. "Neuron:Glia-Verhältnis in der Netzhaut verschiedener Raubtiere." Doctoral thesis, 2012. https://ul.qucosa.de/id/qucosa%3A11970.
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